CN102858380B - 胰岛细胞片、制造方法及其利用方法 - Google Patents

胰岛细胞片、制造方法及其利用方法 Download PDF

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Publication number
CN102858380B
CN102858380B CN201080044395.5A CN201080044395A CN102858380B CN 102858380 B CN102858380 B CN 102858380B CN 201080044395 A CN201080044395 A CN 201080044395A CN 102858380 B CN102858380 B CN 102858380B
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cells
islet
cell sheet
islet cell
polymer
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CN102858380A (zh
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清水裕史
大桥一夫
鹈头理惠
伊势一哉
大和雅之
冈野光夫
后藤满一
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Tokyo Womens Medical University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0676—Pancreatic cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/30—Synthetic polymers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/52—Fibronectin; Laminin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2539/00—Supports and/or coatings for cell culture characterised by properties
    • C12N2539/10—Coating allowing for selective detachment of cells, e.g. thermoreactive coating

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Organic Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Urology & Nephrology (AREA)
  • Genetics & Genomics (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN201080044395.5A 2009-08-02 2010-08-02 胰岛细胞片、制造方法及其利用方法 Expired - Fee Related CN102858380B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2009193648 2009-08-02
JP2009-193648 2009-08-02
PCT/JP2010/063033 WO2011016423A1 (ja) 2009-08-02 2010-08-02 膵島細胞シート、製造方法及びその利用方法

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CN102858380A CN102858380A (zh) 2013-01-02
CN102858380B true CN102858380B (zh) 2016-03-23

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Country Link
US (1) US20120210451A1 (enExample)
EP (1) EP2491957A4 (enExample)
JP (1) JP5717253B2 (enExample)
CN (1) CN102858380B (enExample)
CA (1) CA2769852A1 (enExample)
IN (1) IN2012DN01268A (enExample)
WO (1) WO2011016423A1 (enExample)

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AU2003207288A1 (en) * 2003-02-06 2004-08-30 Cellseed Inc. Anterior ocular-associated cell sheet, three-dimensional construct and process for producing the same
US9981064B2 (en) * 2003-02-20 2018-05-29 Cellseed Inc. Regenerated corneal endothelial cell sheets, processes for producing the same, and methods of using the same
EP1748064B1 (en) * 2004-04-25 2019-04-17 CellSeed Inc. Cultured periodontal ligament cell sheet, process for producing the same and method of use thereof
EP1859817A4 (en) 2005-02-28 2012-11-07 Cellseed Inc CULTIVATED CELL PLATE, METHOD FOR THE PRODUCTION THEREOF, AND METHOD FOR RECONSTRUCTING FABRIC BY USING THE PLATE
WO2006093151A1 (ja) * 2005-02-28 2006-09-08 Cellseed Inc. 培養細胞シート、製造方法及びその利用方法
EP2348099B1 (en) * 2008-10-14 2017-07-05 CellSeed Inc. Temperature-responsive cell culture substrate and method for producing the same
CN103476439A (zh) * 2011-02-28 2013-12-25 学校法人东京女子医科大学 细胞因子产生细胞片及其利用方法
JP2012205516A (ja) 2011-03-29 2012-10-25 Osaka Univ 人工皮膚モデルの製造方法、及び人工皮膚モデル
WO2012137896A1 (ja) * 2011-04-08 2012-10-11 株式会社大塚製薬工場 シート状の膵島の製造方法
EP2857824B1 (en) 2012-05-25 2016-10-12 Tokyo Women's Medical University Method of evaluating wetting characteristic of object
JP6519050B2 (ja) * 2012-09-04 2019-05-29 国立大学法人大阪大学 人工皮膚組織、人工皮膚モデル及びそれらの製造方法
BR112015031253B1 (pt) 2013-06-13 2021-09-28 Orgenesis Ltd. Método para produção de uma população de células transdiferenciada
JP6300287B2 (ja) * 2014-04-14 2018-04-04 学校法人福岡大学 インスリン産生膵島細胞移植用製剤
MA41296A (fr) 2014-12-30 2017-11-07 Orgenesis Ltd Procédés de transdifférenciation et procédés d'utilisation de ceux-ci
MX2017016701A (es) * 2015-06-25 2018-11-09 Auckland Uniservices Ltd Aparato y metodo de cultivo de tejidos.
JP6796332B2 (ja) * 2015-06-26 2020-12-09 国立研究開発法人国立循環器病研究センター 細胞培養器、細胞構造体の製造方法
KR101828696B1 (ko) * 2015-08-26 2018-02-12 울산대학교 산학협력단 인슐린분비세포 이식용 조성물 및 이의 제조방법
JP6593589B2 (ja) * 2015-09-30 2019-10-23 澁谷工業株式会社 細胞塊シートの作製方法および細胞塊シート
US20170304528A1 (en) * 2016-04-22 2017-10-26 DeepScience Ltd. Implantable medical device for delivering cells
EP3635106A4 (en) 2017-05-08 2021-01-06 Orgenesis Ltd. POPULATIONS OF TRANSDIFFERENTIATED CELLS AND THEIR METHODS OF USE
TWI875793B (zh) * 2019-08-08 2025-03-11 學校法人 東京女子醫科大學 創傷被覆用片及創傷被覆方法

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EP0470681A2 (en) * 1990-08-08 1992-02-12 W.R. Grace & Co.-Conn. Cell clusters or sheets comprising a plurality of cell species and preparations thereof
WO2000014542A2 (de) * 1998-09-08 2000-03-16 Privates Institut Bioserv Gmbh Diagnostisches verfahren zur erkennung einer pankreasfunktionsstörung
CN1643133A (zh) * 2002-03-25 2005-07-20 华盛顿大学 嵌合胰腺
CN1753696A (zh) * 2003-02-20 2006-03-29 创革医疗科技有限公司 再生角膜内皮细胞片、制造方法及其使用方法
CN101147704A (zh) * 2006-09-18 2008-03-26 中国人民解放军军事医学科学院野战输血研究所 一种可移植的人工替代单元
WO2008124169A2 (en) * 2007-04-10 2008-10-16 The Trustees Of The University Of Pennsylvania Islet cells composition and methods

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WO2000014542A2 (de) * 1998-09-08 2000-03-16 Privates Institut Bioserv Gmbh Diagnostisches verfahren zur erkennung einer pankreasfunktionsstörung
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CN1753696A (zh) * 2003-02-20 2006-03-29 创革医疗科技有限公司 再生角膜内皮细胞片、制造方法及其使用方法
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IN2012DN01268A (enExample) 2015-05-15
JPWO2011016423A1 (ja) 2013-01-10
CA2769852A1 (en) 2011-02-10
US20120210451A1 (en) 2012-08-16
EP2491957A4 (en) 2013-10-02
EP2491957A1 (en) 2012-08-29
WO2011016423A1 (ja) 2011-02-10
CN102858380A (zh) 2013-01-02
JP5717253B2 (ja) 2015-05-13

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