JP5717253B2 - 膵島細胞シート、製造方法及びその利用方法 - Google Patents

膵島細胞シート、製造方法及びその利用方法 Download PDF

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Publication number
JP5717253B2
JP5717253B2 JP2011525883A JP2011525883A JP5717253B2 JP 5717253 B2 JP5717253 B2 JP 5717253B2 JP 2011525883 A JP2011525883 A JP 2011525883A JP 2011525883 A JP2011525883 A JP 2011525883A JP 5717253 B2 JP5717253 B2 JP 5717253B2
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cells
islet cell
cell sheet
islet
sheet according
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JPWO2011016423A1 (ja
Inventor
裕史 清水
裕史 清水
一夫 大橋
一夫 大橋
理恵 鵜頭
理恵 鵜頭
一哉 伊勢
一哉 伊勢
大和 雅之
雅之 大和
岡野 光夫
光夫 岡野
満一 後藤
満一 後藤
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Tokyo Womens Medical University
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0676Pancreatic cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00Supports or coatings for cell culture, characterised by material
    • C12N2533/30Synthetic polymers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00Supports or coatings for cell culture, characterised by material
    • C12N2533/50Proteins
    • C12N2533/52Fibronectin; Laminin
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2539/00Supports and/or coatings for cell culture characterised by properties
    • C12N2539/10Coating allowing for selective detachment of cells, e.g. thermoreactive coating

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Transplantation (AREA)
  • Organic Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Botany (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Wood Science & Technology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2011525883A 2009-08-02 2010-08-02 膵島細胞シート、製造方法及びその利用方法 Expired - Fee Related JP5717253B2 (ja)

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JP2011525883A JP5717253B2 (ja) 2009-08-02 2010-08-02 膵島細胞シート、製造方法及びその利用方法

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JP2009193648 2009-08-02
JP2009193648 2009-08-02
JP2011525883A JP5717253B2 (ja) 2009-08-02 2010-08-02 膵島細胞シート、製造方法及びその利用方法
PCT/JP2010/063033 WO2011016423A1 (ja) 2009-08-02 2010-08-02 膵島細胞シート、製造方法及びその利用方法

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JPWO2011016423A1 JPWO2011016423A1 (ja) 2013-01-10
JP5717253B2 true JP5717253B2 (ja) 2015-05-13

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US (1) US20120210451A1 (enExample)
EP (1) EP2491957A4 (enExample)
JP (1) JP5717253B2 (enExample)
CN (1) CN102858380B (enExample)
CA (1) CA2769852A1 (enExample)
IN (1) IN2012DN01268A (enExample)
WO (1) WO2011016423A1 (enExample)

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WO2004070023A1 (ja) * 2003-02-06 2004-08-19 Cellseed Inc. 前眼部関連細胞シート、3次元構造体、及びそれらの製造法
JP4335873B2 (ja) * 2003-02-20 2009-09-30 株式会社セルシード 再生角膜内皮細胞シート、製造方法及びその利用方法
JP4827729B2 (ja) * 2004-04-25 2011-11-30 株式会社セルシード 培養歯根膜細胞シート、製造方法及びその利用方法
JP4921353B2 (ja) * 2005-02-28 2012-04-25 株式会社セルシード 培養細胞シート、製造方法及びその利用方法
JPWO2006093153A1 (ja) 2005-02-28 2008-08-07 株式会社セルシード 培養細胞シート、製造方法及びその利用した組織修復方法
US9598668B2 (en) * 2008-10-14 2017-03-21 Cellseed Inc. Temperature-responsive cell culture substrate and method for producing the same
WO2012118099A1 (ja) * 2011-02-28 2012-09-07 学校法人 東京女子医科大学 サイトカイン産生細胞シートとその利用方法
JP2012205516A (ja) 2011-03-29 2012-10-25 Osaka Univ 人工皮膚モデルの製造方法、及び人工皮膚モデル
SG194151A1 (en) * 2011-04-08 2013-11-29 Otsuka Pharma Co Ltd Method for producing sheet-like pancreatic islet
JP6189291B2 (ja) 2012-05-25 2017-08-30 学校法人東京女子医科大学 物質の濡れ性評価法
US20150250925A1 (en) * 2012-09-04 2015-09-10 Biomedical Technology Hybrid Co., Ltd. Artificial skin tissue, artificial skin model and manufacturing method therefor
CN105555950B (zh) * 2013-06-13 2021-03-05 奥尔吉尼西丝有限公司 细胞群体、转分化的方法及其使用方法
WO2015159889A1 (ja) * 2014-04-14 2015-10-22 学校法人福岡大学 インスリン産生細胞移植方法
MA41296A (fr) 2014-12-30 2017-11-07 Orgenesis Ltd Procédés de transdifférenciation et procédés d'utilisation de ceux-ci
EP3313976A4 (en) * 2015-06-25 2019-02-20 Auckland Uniservices Limited TISSUE CULTURE DEVICE AND METHOD
EP3315596A4 (en) * 2015-06-26 2019-02-13 National Cerebral and Cardiovascular Center CELL CULTURE CONTAINER
KR101828696B1 (ko) * 2015-08-26 2018-02-12 울산대학교 산학협력단 인슐린분비세포 이식용 조성물 및 이의 제조방법
JP6593589B2 (ja) * 2015-09-30 2019-10-23 澁谷工業株式会社 細胞塊シートの作製方法および細胞塊シート
US20170304528A1 (en) * 2016-04-22 2017-10-26 DeepScience Ltd. Implantable medical device for delivering cells
SG11201911256UA (en) 2017-05-08 2020-01-30 Orgenesis Ltd Transdifferentiated cell populations and methods of use thereof
TWI875793B (zh) * 2019-08-08 2025-03-11 學校法人 東京女子醫科大學 創傷被覆用片及創傷被覆方法

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WO1997028252A1 (en) * 1996-01-31 1997-08-07 Vivorx Pharmaceuticals, Inc. Process for aggregating cells and forming sheets of mammalian tissue in a horizontally rotating bioreactor
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JP2006519865A (ja) * 2003-03-07 2006-08-31 エイセル, インコーポレイテッド 組織の修復および器官欠損の処置のための脱細胞化された肝臓
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Also Published As

Publication number Publication date
EP2491957A4 (en) 2013-10-02
IN2012DN01268A (enExample) 2015-05-15
JPWO2011016423A1 (ja) 2013-01-10
CA2769852A1 (en) 2011-02-10
EP2491957A1 (en) 2012-08-29
CN102858380B (zh) 2016-03-23
WO2011016423A1 (ja) 2011-02-10
US20120210451A1 (en) 2012-08-16
CN102858380A (zh) 2013-01-02

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