CN102781900A - 从含有琥珀酸铵的发酵液纯化琥珀酸 - Google Patents

从含有琥珀酸铵的发酵液纯化琥珀酸 Download PDF

Info

Publication number
CN102781900A
CN102781900A CN201080059513XA CN201080059513A CN102781900A CN 102781900 A CN102781900 A CN 102781900A CN 201080059513X A CN201080059513X A CN 201080059513XA CN 201080059513 A CN201080059513 A CN 201080059513A CN 102781900 A CN102781900 A CN 102781900A
Authority
CN
China
Prior art keywords
acid
ion exchange
succinic acid
exchange resin
ammonium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201080059513XA
Other languages
English (en)
Chinese (zh)
Inventor
S·J·格贝尔丁
R·辛格
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Myriant Corp
Original Assignee
Myriant Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Myriant Corp filed Critical Myriant Corp
Publication of CN102781900A publication Critical patent/CN102781900A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C55/00Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
    • C07C55/02Dicarboxylic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42Separation; Purification; Stabilisation; Use of additives
    • C07C51/43Separation; Purification; Stabilisation; Use of additives by change of the physical state, e.g. crystallisation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42Separation; Purification; Stabilisation; Use of additives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42Separation; Purification; Stabilisation; Use of additives
    • C07C51/47Separation; Purification; Stabilisation; Use of additives by solid-liquid treatment; by chemisorption
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C55/00Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
    • C07C55/02Dicarboxylic acids
    • C07C55/10Succinic acid
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C55/00Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
    • C07C55/02Dicarboxylic acids
    • C07C55/14Adipic acid
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/04Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using bacteria
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/40Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/44Polycarboxylic acids
    • C12P7/46Dicarboxylic acids having four or less carbon atoms, e.g. fumaric acid, maleic acid
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/582Recycling of unreacted starting or intermediate materials

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Mycology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN201080059513XA 2009-12-31 2010-12-31 从含有琥珀酸铵的发酵液纯化琥珀酸 Pending CN102781900A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US33518909P 2009-12-31 2009-12-31
US61/335,189 2009-12-31
PCT/US2010/062635 WO2011082378A2 (en) 2009-12-31 2010-12-31 Purification of succinic acid from the fermentation broth containing ammonium succinate

Publications (1)

Publication Number Publication Date
CN102781900A true CN102781900A (zh) 2012-11-14

Family

ID=44227170

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201080059513XA Pending CN102781900A (zh) 2009-12-31 2010-12-31 从含有琥珀酸铵的发酵液纯化琥珀酸

Country Status (6)

Country Link
US (1) US9233906B2 (https=)
EP (2) EP2918574A1 (https=)
JP (1) JP2013516180A (https=)
KR (1) KR20120099154A (https=)
CN (1) CN102781900A (https=)
WO (1) WO2011082378A2 (https=)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105073703A (zh) * 2013-01-03 2015-11-18 蒂森克虏伯工业解决方案股份公司 从发酵液中纯化羧酸的方法
CN109612978A (zh) * 2018-10-30 2019-04-12 欣旺达电子股份有限公司 锂离子电池电极膜片补锂量检测方法
CN111164215A (zh) * 2017-10-02 2020-05-15 代谢探索者公司 用于从发酵液产生有机酸盐的方法
CN111732502A (zh) * 2019-07-02 2020-10-02 安徽丰原发酵技术工程研究有限公司 一种分离苹果酸与丁二酸的方法
CN111732507A (zh) * 2019-07-02 2020-10-02 安徽丰原发酵技术工程研究有限公司 一种生产l-苹果酸联产丁二酸的方法

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102010025167A1 (de) * 2010-06-25 2011-12-29 Uhde Gmbh Verfahren zur Abtrennung, Gewinnung und Reinigung von Bernsteinsäure
DE102011120632A1 (de) * 2011-12-09 2013-06-13 Thyssenkrupp Uhde Gmbh Verfahren zur Aufreinigung von Carbonsäuren aus Fermentationsbrühen
EP2847342B1 (en) * 2012-05-07 2020-08-12 Archer Daniels Midland Co. Purification of succinic acid
ES2531399T3 (es) 2012-05-24 2015-03-13 Purac Biochem Nv Recuperación de ácido carboxílico de una mezcla de carboxilato de magnesio
KR101540520B1 (ko) * 2012-11-29 2015-07-30 롯데케미칼 주식회사 역삼투막을 이용한 숙신산 정제 방법
EP2745905A1 (en) 2012-12-21 2014-06-25 ThyssenKrupp Uhde GmbH Process for the purification of carboxylic acids by subcritical or supercritical fluid chromatography
WO2015031112A1 (en) * 2013-08-27 2015-03-05 Purolite Corporation Ion exchange resin regeneration method
EP3041942B1 (en) 2013-09-03 2020-07-01 PTT Global Chemical Public Company Limited A process for manufacturing acrylic acid, acrylonitrile and 1,4-butanediol from 1,3-propanediol
MY193588A (en) 2014-02-07 2022-10-19 Basf Se Improved microorganisms for succinic acid production
KR102304838B1 (ko) 2014-02-07 2021-09-28 바스프 에스이 개선된 바이오매스 분리 거동을 갖는 변형된 미생물
FR3028864B1 (fr) 2014-11-26 2018-05-18 Roquette Freres Procede de recuperation de cristaux d'acide succinique avec mise en œuvre de tensioactifs au cours de la cristallisation, cristaux obtenus et leurs utilisations
WO2016164798A1 (en) * 2015-04-08 2016-10-13 Invista North America S.A.R.L. Materials and methods for the selective recovery of multivalent products
WO2016164748A1 (en) * 2015-04-08 2016-10-13 Invista North America S.A.R.L. Materials and methods for the selective recovery of monovalent products from aqueous solutions using continuous ion exchange
US11279955B2 (en) 2017-05-19 2022-03-22 Basf Se Process for producing an organic compound
CN109206313B (zh) * 2017-07-05 2021-06-11 中国石化扬子石油化工有限公司 丁二酸盐厌氧发酵液制备丁二酸的方法
PL236607B1 (pl) * 2017-11-09 2021-02-08 Politechnika Poznanska Sposób wydzielania kwasu bursztynowego z brzeczki fermentacyjnej
EP3502241A1 (en) 2017-12-21 2019-06-26 Basf Se Modified microorganism for improved production of succinate
US12090420B2 (en) 2018-09-18 2024-09-17 Inv Nylon Chemicals Americas, Llc Systems and methods for recovering amines and their derivatives from aqueous mixtures
US12011146B2 (en) 2020-04-30 2024-06-18 Ambu A/S Method of assembly of an endoscope control system
US11518762B2 (en) * 2020-06-04 2022-12-06 Florida State University Research Foundation, Inc. Large scale purification of castanospermine
IT202000017368A1 (it) 2020-07-16 2022-01-16 Radici Chimica S P A Purificazione di acidi dicarbossilici alifatici prodotti mediante processi biotecnologici
US20250269366A1 (en) * 2020-09-21 2025-08-28 Lygos, Inc. Continuous ion exchange and esterification of fermented malonic acid
US20240197938A1 (en) * 2021-01-04 2024-06-20 Harcros Chemicals, Inc. Antimicrobial compounds based on glucoheptonic acids and their salts
US11952609B2 (en) 2021-03-01 2024-04-09 Battelle Energy Alliance, Llc Methods of producing succinic acid from a biomass

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5132456A (en) * 1991-05-07 1992-07-21 The Regents Of The University Of California Sorption of carboxylic acid from carboxylic salt solutions at PHS close to or above the pKa of the acid, with regeneration with an aqueous solution of ammonia or low-molecular-weight alkylamine
US5958744A (en) * 1997-08-18 1999-09-28 Applied Carbochemicals Succinic acid production and purification
US6284904B1 (en) * 1998-03-02 2001-09-04 Michigan Biotechnology Institute Purification of organic acids using anion exchange chromatography
CN1860237A (zh) * 2003-09-30 2006-11-08 味之素株式会社 从发酵液中纯化琥珀酸的方法

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2664441A (en) * 1951-07-19 1953-12-29 Harry S Owens Separation of organic acids
JPS58164541A (ja) * 1982-03-25 1983-09-29 Mitsubishi Chem Ind Ltd 多価カルボン酸の精製方法
US5143834A (en) * 1986-06-11 1992-09-01 Glassner David A Process for the production and purification of succinic acid
EP0249773B1 (en) 1986-06-11 1992-12-16 Michigan Biotechnology Institute A process for the production of succinic acid by anaerobic fermentation
US5168055A (en) 1986-06-11 1992-12-01 Rathin Datta Fermentation and purification process for succinic acid
US5068419A (en) 1986-12-18 1991-11-26 Uop Separation of an organic acid from a fermentation broth with an anionic polymeric adsorbent
ATE123305T1 (de) 1987-12-22 1995-06-15 Willem Hemmo Kampen Verfahren zur produktion von ethanol, glycerin und bernsteinsäure.
US5068418A (en) 1989-05-08 1991-11-26 Uop Separation of lactic acid from fermentation broth with an anionic polymeric absorbent
US5034105A (en) 1989-07-27 1991-07-23 Michigan Biotechnology Institute Carboxylic acid purification and crystallization process
US5104492A (en) 1990-07-11 1992-04-14 The Regents Of The University Of California Recovery of carboxylic acids from water by precipitation from organic solutions
US5412126A (en) 1991-04-17 1995-05-02 The Regents Of The University Of California Carboxylic acid sorption regeneration process
US5786185A (en) 1991-09-13 1998-07-28 Reilly Industries, Inc. Process for producing and recovering lactic acid
AT398982B (de) 1993-02-18 1995-02-27 Vogelbusch Gmbh Verfahren zur abtrennung und reinigung von milchsäure
IL108340A (en) 1993-03-04 1996-10-16 Innova Sa Citric acid extraction
JP3750026B2 (ja) * 1994-03-24 2006-03-01 日本コーンスターチ株式会社 水素化澱粉水解組成物
JPH08176133A (ja) 1994-12-26 1996-07-09 Takeda Chem Ind Ltd L−アスコルビン酸の精製法
US5770435A (en) 1995-11-02 1998-06-23 University Of Chicago Mutant E. coli strain with increased succinic acid production
IL119389A (en) 1996-10-09 2001-10-31 Cargill Inc Process for the recovery of lactic acid by liquid-liquid extraction using a cation exchanger
US6160173A (en) 1996-10-09 2000-12-12 Cargill Incorporated Process for the recovery of lactic acid esters and amides from aqueous solutions of lactic acid and/or salts thereof
NZ336852A (en) 1996-12-23 2000-06-23 Lactascan Aps Production of lactic acid from whey proteins where electrodialysis causes less biofouling of the electrodialysis membrane
IL119986A (en) 1997-01-09 2000-10-31 Amylum Nv Process for the production of crystalline aspartic acid
WO1999053035A1 (en) 1998-04-13 1999-10-21 The University Of Georgia Research Foundation, Inc. Pyruvate carboxylase overexpression for enhanced production of oxaloacetate-derived biochemicals in microbial cells
US6159738A (en) 1998-04-28 2000-12-12 University Of Chicago Method for construction of bacterial strains with increased succinic acid production
FR2799754A1 (fr) 1999-10-18 2001-04-20 Roquette Freres Procede de separation et de purification d'acide lactique a partir d'un milieu de fermentation
MY137537A (en) 2002-05-10 2009-02-27 Mitsubishi Chem Corp Method for producing organic acid
US7241918B1 (en) 2003-03-18 2007-07-10 Uop Llc Separation of citric acid from gluconic acid in fermentation broth using a weakly or strongly basic anionic exchange resin adsorbent
JP4469568B2 (ja) 2003-07-09 2010-05-26 三菱化学株式会社 有機酸の製造方法
CN100575496C (zh) 2003-08-28 2009-12-30 三菱化学株式会社 产生琥珀酸的方法
EP1672067B1 (en) 2003-09-17 2015-11-11 Mitsubishi Chemical Corporation Process for producing non-amino organic acid
KR101245428B1 (ko) 2004-08-27 2013-03-19 라이스 유니버시티 숙신산 생산이 증가된 돌연변이 대장균 균주
TWI372763B (en) * 2005-06-17 2012-09-21 Wyeth Llc Methods of purifying anti a beta antibodies
JP4193820B2 (ja) 2005-07-05 2008-12-10 ブラザー工業株式会社 管理装置、およびプログラム
WO2007040458A1 (en) 2005-10-06 2007-04-12 Hyflux Ip Resources Pte Ltd Process for recovery and purification of lactic acid
JP5088136B2 (ja) 2005-10-18 2012-12-05 味の素株式会社 コハク酸の製造方法
JP5365824B2 (ja) * 2006-03-23 2013-12-11 独立行政法人産業技術総合研究所 コハク酸ジアルキルの製造方法および1,4−ブタンジオールの製造方法
EP1842843A1 (de) 2006-04-04 2007-10-10 Basf Aktiengesellschaft Verfahren zur Herstellung eines Carbonsäurealkylesters
CA2688938C (en) 2007-03-20 2018-01-16 University Of Florida Research Foundation, Inc. Materials and methods for efficient succinate and malate production
JP3135606U (ja) 2007-07-12 2007-09-20 株式会社ノルコーポレーション 収納フレーム
EP2687602A1 (en) 2007-11-20 2014-01-22 DSM IP Assets B.V. Succinic acid production in a eukaryotic cell
FR2925068B1 (fr) 2007-12-13 2010-01-08 Roquette Freres Procedes de production d'acide succinique
KR20090066958A (ko) 2007-12-20 2009-06-24 한국과학기술원 배양액의 결정화에 의한 숙신산 정제방법
CN101215583B (zh) * 2008-01-18 2010-11-10 南京工业大学 一种发酵与膜分离单元耦合制备丁二酸的方法
AU2010232533A1 (en) 2009-04-02 2011-10-13 University Of Florida Research Foundation, Inc. Engineering the pathway for succinate production
US20120238722A1 (en) * 2009-11-24 2012-09-20 Roquette Freres Sa Process for the crystallization of succinic acid

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5132456A (en) * 1991-05-07 1992-07-21 The Regents Of The University Of California Sorption of carboxylic acid from carboxylic salt solutions at PHS close to or above the pKa of the acid, with regeneration with an aqueous solution of ammonia or low-molecular-weight alkylamine
US5958744A (en) * 1997-08-18 1999-09-28 Applied Carbochemicals Succinic acid production and purification
US6284904B1 (en) * 1998-03-02 2001-09-04 Michigan Biotechnology Institute Purification of organic acids using anion exchange chromatography
CN1860237A (zh) * 2003-09-30 2006-11-08 味之素株式会社 从发酵液中纯化琥珀酸的方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HYOHAK SONG ET AL: "Recovery of succinic acid produced by fermentation of a metabolically engineered Mannheimia succiniciproducens strain", 《JOURNAL OF BIOTECHNOLOGY》 *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105073703A (zh) * 2013-01-03 2015-11-18 蒂森克虏伯工业解决方案股份公司 从发酵液中纯化羧酸的方法
CN111164215A (zh) * 2017-10-02 2020-05-15 代谢探索者公司 用于从发酵液产生有机酸盐的方法
CN109612978A (zh) * 2018-10-30 2019-04-12 欣旺达电子股份有限公司 锂离子电池电极膜片补锂量检测方法
CN111732502A (zh) * 2019-07-02 2020-10-02 安徽丰原发酵技术工程研究有限公司 一种分离苹果酸与丁二酸的方法
CN111732507A (zh) * 2019-07-02 2020-10-02 安徽丰原发酵技术工程研究有限公司 一种生产l-苹果酸联产丁二酸的方法
CN111732507B (zh) * 2019-07-02 2022-07-15 安徽丰原发酵技术工程研究有限公司 一种生产l-苹果酸联产丁二酸的方法

Also Published As

Publication number Publication date
EP2519491A4 (en) 2014-10-08
US20120289742A1 (en) 2012-11-15
KR20120099154A (ko) 2012-09-06
EP2918574A1 (en) 2015-09-16
WO2011082378A2 (en) 2011-07-07
WO2011082378A3 (en) 2011-11-03
EP2519491A2 (en) 2012-11-07
US9233906B2 (en) 2016-01-12
JP2013516180A (ja) 2013-05-13

Similar Documents

Publication Publication Date Title
CN102781900A (zh) 从含有琥珀酸铵的发酵液纯化琥珀酸
US11377462B2 (en) Process for the purification of a neutral human milk oligosaccharide (HMO) from microbial fermentation
Cheng et al. Downstream processing of biotechnological produced succinic acid
US5641406A (en) Lactic acid extraction and purification process
US8273181B2 (en) Process of removing calcium and obtaining sulfate salts from an aqueous sugar solution
JP2012518424A (ja) 分離方法
JP2017506620A (ja) 芳香族アミノ酸を精製する方法
WO2012155074A1 (en) Process for purifying lignocellulosic feedstocks
KR20160048847A (ko) 양이온 교환 수지의 블렌드를 사용하는 당의 크로마토그래피 분리
CN106366137A (zh) 一种异构化乳糖液的脱盐脱色方法
WO2018035573A1 (en) Desalination process
KR20230098181A (ko) 발효액으로부터 산성 모유 올리고당의 정제 방법
WO2019138338A1 (en) Process of separation and purification of glycerol derivatives
NL8503286A (nl) Werkwijze voor het afscheiden en zuiveren van l-fenylalanine.
CN1125037C (zh) 生产谷氨酸的方法
CN113956304A (zh) 一种n-乙酰神经氨酸的制备方法
JPH08229413A (ja) トリメリット酸製造用酸化触媒の分離方法
JP4662421B2 (ja) 有機酸の分離製造方法
CN105238841A (zh) 头孢菌素c吸附废液中dcpc的回收与转化方法
CN100425618C (zh) 一种连续分离5’-核苷三磷酸的方法
JP4662419B2 (ja) 有機酸を分離製造する方法
US7235180B2 (en) Sulfate-selective anion exchange resins for use in combination with TRSS resins in feed water treatment
KR20230080037A (ko) 3-하이드록시프로피온산의 회수 공정
de Wit et al. Hybridizing Simulated Moving Bed and Electrodialysis: Product Purification and Eluent Regeneration
JPH11221100A (ja) 甜菜糖液精製方法

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20121114