CN102574864B - 稠合的氨基二氢嘧啶酮衍生物 - Google Patents

稠合的氨基二氢嘧啶酮衍生物 Download PDF

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Publication number
CN102574864B
CN102574864B CN201080034140.0A CN201080034140A CN102574864B CN 102574864 B CN102574864 B CN 102574864B CN 201080034140 A CN201080034140 A CN 201080034140A CN 102574864 B CN102574864 B CN 102574864B
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CN
China
Prior art keywords
amino
fluorophenyl
compound
pyrimidin
oxo
Prior art date
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Expired - Fee Related
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CN201080034140.0A
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English (en)
Chinese (zh)
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CN102574864A (zh
Inventor
J·L·卡斯特罗皮内罗
A·哈尔
A·马丁
N-T·维欧
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Eisai R&D Management Co Ltd
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Eisai R&D Management Co Ltd
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Expired - Fee Related legal-status Critical Current
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201080034140.0A 2009-07-22 2010-07-21 稠合的氨基二氢嘧啶酮衍生物 Expired - Fee Related CN102574864B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0912777.0 2009-07-22
GB0912777A GB0912777D0 (en) 2009-07-22 2009-07-22 Fused aminodihydropyrimidone derivatives
PCT/EP2010/060586 WO2011009897A1 (en) 2009-07-22 2010-07-21 Fused aminodihydropyrimidone derivatives

Publications (2)

Publication Number Publication Date
CN102574864A CN102574864A (zh) 2012-07-11
CN102574864B true CN102574864B (zh) 2015-04-29

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CN201080034140.0A Expired - Fee Related CN102574864B (zh) 2009-07-22 2010-07-21 稠合的氨基二氢嘧啶酮衍生物

Country Status (10)

Country Link
US (1) US9139594B2 (https=)
EP (1) EP2456771A1 (https=)
JP (1) JP5699146B2 (https=)
KR (1) KR20120052343A (https=)
CN (1) CN102574864B (https=)
AU (1) AU2010275196B2 (https=)
CA (1) CA2768881A1 (https=)
GB (1) GB0912777D0 (https=)
IN (1) IN2012DN00688A (https=)
WO (1) WO2011009897A1 (https=)

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RU2476431C2 (ru) 2008-01-18 2013-02-27 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Конденсированное производное аминодигидротиазина
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CN102186841A (zh) 2008-10-22 2011-09-14 盐野义制药株式会社 具有bace1抑制活性的2-氨基嘧啶-4-酮及2-氨基吡啶衍生物
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Also Published As

Publication number Publication date
WO2011009897A1 (en) 2011-01-27
AU2010275196B2 (en) 2015-08-06
CN102574864A (zh) 2012-07-11
JP5699146B2 (ja) 2015-04-08
AU2010275196A1 (en) 2012-02-16
JP2012533602A (ja) 2012-12-27
GB0912777D0 (en) 2009-08-26
US20120202828A1 (en) 2012-08-09
CA2768881A1 (en) 2011-01-27
KR20120052343A (ko) 2012-05-23
US9139594B2 (en) 2015-09-22
EP2456771A1 (en) 2012-05-30
IN2012DN00688A (https=) 2015-06-19

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