IN2012DN00688A - - Google Patents

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Publication number
IN2012DN00688A
IN2012DN00688A IN688DEN2012A IN2012DN00688A IN 2012DN00688 A IN2012DN00688 A IN 2012DN00688A IN 688DEN2012 A IN688DEN2012 A IN 688DEN2012A IN 2012DN00688 A IN2012DN00688 A IN 2012DN00688A
Authority
IN
India
Prior art keywords
hydrogen atom
independently
ring
inhibitory effect
aryl group
Prior art date
Application number
Other languages
English (en)
Inventor
Luis Castro Pineiro Jose
Hall Adrian
Madin Andrew
Vo Ngoc-Tri
Original Assignee
Eisai R & D Man Co Led
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R & D Man Co Led filed Critical Eisai R & D Man Co Led
Publication of IN2012DN00688A publication Critical patent/IN2012DN00688A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IN688DEN2012 2009-07-22 2010-07-21 IN2012DN00688A (https=)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0912777A GB0912777D0 (en) 2009-07-22 2009-07-22 Fused aminodihydropyrimidone derivatives
PCT/EP2010/060586 WO2011009897A1 (en) 2009-07-22 2010-07-21 Fused aminodihydropyrimidone derivatives

Publications (1)

Publication Number Publication Date
IN2012DN00688A true IN2012DN00688A (https=) 2015-06-19

Family

ID=41058390

Family Applications (1)

Application Number Title Priority Date Filing Date
IN688DEN2012 IN2012DN00688A (https=) 2009-07-22 2010-07-21

Country Status (10)

Country Link
US (1) US9139594B2 (https=)
EP (1) EP2456771A1 (https=)
JP (1) JP5699146B2 (https=)
KR (1) KR20120052343A (https=)
CN (1) CN102574864B (https=)
AU (1) AU2010275196B2 (https=)
CA (1) CA2768881A1 (https=)
GB (1) GB0912777D0 (https=)
IN (1) IN2012DN00688A (https=)
WO (1) WO2011009897A1 (https=)

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GB201101140D0 (en) 2011-01-21 2011-03-09 Eisai Ltd Fused aminodihydrothiazine derivatives
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US8883779B2 (en) 2011-04-26 2014-11-11 Shinogi & Co., Ltd. Oxazine derivatives and a pharmaceutical composition for inhibiting BACE1 containing them
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RU2014142545A (ru) 2012-04-27 2016-06-27 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Способ получения 5-(дифторметил)пиразин-2-карбоновой кислоты и промежуточного соединения при ее получении
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GB201101139D0 (en) 2011-01-21 2011-03-09 Eisai Ltd Fused aminodihydrothiazine derivatives

Also Published As

Publication number Publication date
AU2010275196B2 (en) 2015-08-06
JP2012533602A (ja) 2012-12-27
CA2768881A1 (en) 2011-01-27
US9139594B2 (en) 2015-09-22
JP5699146B2 (ja) 2015-04-08
WO2011009897A1 (en) 2011-01-27
KR20120052343A (ko) 2012-05-23
EP2456771A1 (en) 2012-05-30
US20120202828A1 (en) 2012-08-09
CN102574864A (zh) 2012-07-11
GB0912777D0 (en) 2009-08-26
AU2010275196A1 (en) 2012-02-16
CN102574864B (zh) 2015-04-29

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