AU2010275196B2 - Fused aminodihydropyrimidone derivatives - Google Patents

Fused aminodihydropyrimidone derivatives Download PDF

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Publication number
AU2010275196B2
AU2010275196B2 AU2010275196A AU2010275196A AU2010275196B2 AU 2010275196 B2 AU2010275196 B2 AU 2010275196B2 AU 2010275196 A AU2010275196 A AU 2010275196A AU 2010275196 A AU2010275196 A AU 2010275196A AU 2010275196 B2 AU2010275196 B2 AU 2010275196B2
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AU
Australia
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group
optionally
compound
substituents selected
substituent group
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Ceased
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AU2010275196A
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English (en)
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AU2010275196A1 (en
Inventor
Jose Luis Castro Pineiro
Adrian Hall
Andrew Madin
Ngoc-Tri Vo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai R&D Management Co Ltd
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Eisai R&D Management Co Ltd
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Application filed by Eisai R&D Management Co Ltd filed Critical Eisai R&D Management Co Ltd
Publication of AU2010275196A1 publication Critical patent/AU2010275196A1/en
Application granted granted Critical
Publication of AU2010275196B2 publication Critical patent/AU2010275196B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU2010275196A 2009-07-22 2010-07-21 Fused aminodihydropyrimidone derivatives Ceased AU2010275196B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0912777.0 2009-07-22
GB0912777A GB0912777D0 (en) 2009-07-22 2009-07-22 Fused aminodihydropyrimidone derivatives
PCT/EP2010/060586 WO2011009897A1 (en) 2009-07-22 2010-07-21 Fused aminodihydropyrimidone derivatives

Publications (2)

Publication Number Publication Date
AU2010275196A1 AU2010275196A1 (en) 2012-02-16
AU2010275196B2 true AU2010275196B2 (en) 2015-08-06

Family

ID=41058390

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2010275196A Ceased AU2010275196B2 (en) 2009-07-22 2010-07-21 Fused aminodihydropyrimidone derivatives

Country Status (10)

Country Link
US (1) US9139594B2 (https=)
EP (1) EP2456771A1 (https=)
JP (1) JP5699146B2 (https=)
KR (1) KR20120052343A (https=)
CN (1) CN102574864B (https=)
AU (1) AU2010275196B2 (https=)
CA (1) CA2768881A1 (https=)
GB (1) GB0912777D0 (https=)
IN (1) IN2012DN00688A (https=)
WO (1) WO2011009897A1 (https=)

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RU2416603C9 (ru) 2005-10-25 2012-06-20 Сионоги Энд Ко., Лтд. Производные аминодигидротиазина
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EP2147914B1 (en) 2007-04-24 2014-06-04 Shionogi&Co., Ltd. Aminodihydrothiazine derivatives substituted with cyclic groups
RU2476431C2 (ru) 2008-01-18 2013-02-27 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Конденсированное производное аминодигидротиазина
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EP2318416B1 (en) 2008-07-28 2013-09-04 Eisai R&D Management Co., Ltd. Spiroaminodihydrothiazine derivatives
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CN102186841A (zh) 2008-10-22 2011-09-14 盐野义制药株式会社 具有bace1抑制活性的2-氨基嘧啶-4-酮及2-氨基吡啶衍生物
GB0912778D0 (en) 2009-07-22 2009-08-26 Eisai London Res Lab Ltd Fused aminodihydro-oxazine derivatives
GB0912777D0 (en) 2009-07-22 2009-08-26 Eisai London Res Lab Ltd Fused aminodihydropyrimidone derivatives
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GB201101139D0 (en) 2011-01-21 2011-03-09 Eisai Ltd Fused aminodihydrothiazine derivatives
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TW201247635A (en) 2011-04-26 2012-12-01 Shionogi & Co Oxazine derivatives and a pharmaceutical composition for inhibiting BAC1 containing them
RU2014111055A (ru) 2011-08-22 2015-09-27 Мерк Шарп И Доум Корп. 2-спирозамещенные иминотиазины и их моно- и диоксиды в качестве ингибиторов bace, композиции и их применение
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Also Published As

Publication number Publication date
WO2011009897A1 (en) 2011-01-27
CN102574864A (zh) 2012-07-11
CN102574864B (zh) 2015-04-29
JP5699146B2 (ja) 2015-04-08
AU2010275196A1 (en) 2012-02-16
JP2012533602A (ja) 2012-12-27
GB0912777D0 (en) 2009-08-26
US20120202828A1 (en) 2012-08-09
CA2768881A1 (en) 2011-01-27
KR20120052343A (ko) 2012-05-23
US9139594B2 (en) 2015-09-22
EP2456771A1 (en) 2012-05-30
IN2012DN00688A (https=) 2015-06-19

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MK14 Patent ceased section 143(a) (annual fees not paid) or expired