MX2015015614A - Derivados de aril sultama como moduladores del receptor huerfano relacionado con el receptor del retinoide (rorc). - Google Patents

Derivados de aril sultama como moduladores del receptor huerfano relacionado con el receptor del retinoide (rorc).

Info

Publication number
MX2015015614A
MX2015015614A MX2015015614A MX2015015614A MX2015015614A MX 2015015614 A MX2015015614 A MX 2015015614A MX 2015015614 A MX2015015614 A MX 2015015614A MX 2015015614 A MX2015015614 A MX 2015015614A MX 2015015614 A MX2015015614 A MX 2015015614A
Authority
MX
Mexico
Prior art keywords
sultam derivatives
aryl
rorc modulators
rorc
modulators
Prior art date
Application number
MX2015015614A
Other languages
English (en)
Inventor
Benjamin Fauber
Olivier Rene
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2015015614A publication Critical patent/MX2015015614A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/02—1,2-Thiazines; Hydrogenated 1,2-thiazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

La presente invención se refiere a los compuestos de la fórmula I o a las sales farmacéuticamente aceptables de los mismos, en donde m, n, p, q, Ar, A, W, X1, X2, X3, X4, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 y R11 son como se definieron aquí. También se describen métodos de fabricación de los compuestos y el uso de los compuestos para el tratamiento de enfermedades inflamatorias tales como la artritis.
MX2015015614A 2013-06-21 2014-06-20 Derivados de aril sultama como moduladores del receptor huerfano relacionado con el receptor del retinoide (rorc). MX2015015614A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361837757P 2013-06-21 2013-06-21
PCT/EP2014/062983 WO2014202741A1 (en) 2013-06-21 2014-06-20 ARYL SULTAM DERIVATIVES AS RORc MODULATORS

Publications (1)

Publication Number Publication Date
MX2015015614A true MX2015015614A (es) 2016-03-03

Family

ID=51022842

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015015614A MX2015015614A (es) 2013-06-21 2014-06-20 Derivados de aril sultama como moduladores del receptor huerfano relacionado con el receptor del retinoide (rorc).

Country Status (11)

Country Link
US (1) US20170296550A1 (es)
EP (1) EP3010919B1 (es)
JP (1) JP2016522240A (es)
KR (1) KR20160023676A (es)
CN (1) CN105308042A (es)
BR (1) BR112015032077A2 (es)
CA (1) CA2911963A1 (es)
HK (1) HK1220976A1 (es)
MX (1) MX2015015614A (es)
RU (1) RU2015153834A (es)
WO (1) WO2014202741A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2932888A1 (en) * 2014-01-10 2015-07-16 F. Hoffmann-La Roche Ag Aryl sultam derivatives as rorc modulators
MX2016008721A (es) * 2014-01-10 2017-01-26 Hoffmann La Roche Derivados de aril sultama como moduladores del receptor huerfano relacionado con acido retinoico (rorc).
WO2017005668A1 (en) * 2015-07-08 2017-01-12 F. Hoffmann-La Roche Ag ARYL SULTAM DERIVATIVES AS RORc MODULATORS
WO2017102796A1 (en) * 2015-12-16 2017-06-22 F. Hoffmann-La Roche Ag HETEROARYL AMIDE SULTAM DERIVATIVES AS RORc MODULATORS
BR112022000325A2 (pt) 2019-07-11 2022-03-15 Escape Bio Inc Indazois e azaindazois como inibidores de lrrk2

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101253172A (zh) * 2005-06-27 2008-08-27 布里斯托尔-迈尔斯·斯奎布公司 用于治疗血栓症状的p2y1受体的n－连接的杂环拮抗剂
JPWO2011007819A1 (ja) * 2009-07-17 2012-12-27 塩野義製薬株式会社 ラクタムまたはベンゼンスルホンアミド化合物を含有する医薬
WO2012064744A2 (en) * 2010-11-08 2012-05-18 Lycera Corporation Tetrahydroquinoline and related bicyclic compounds for inhibition of rorϒ activity and the treatment of disease
WO2013064231A1 (en) * 2011-10-31 2013-05-10 Phenex Pharmaceuticals Ag SEVEN-MEMBERED SULFONAMIDES AS MODULATORS OF RAR-RELATED ORPHAN RECEPTOR-GAMMA (RORγ, NR1F3)
AR092348A1 (es) * 2012-07-11 2015-04-15 Hoffmann La Roche DERIVADOS DE ARIL-SULTAMO COMO MODULADORES DE RORc

Also Published As

Publication number Publication date
EP3010919A1 (en) 2016-04-27
CA2911963A1 (en) 2014-12-24
KR20160023676A (ko) 2016-03-03
US20170296550A1 (en) 2017-10-19
HK1220976A1 (zh) 2017-05-19
WO2014202741A1 (en) 2014-12-24
CN105308042A (zh) 2016-02-03
BR112015032077A2 (pt) 2017-07-25
RU2015153834A (ru) 2017-07-26
EP3010919B1 (en) 2017-04-12
JP2016522240A (ja) 2016-07-28

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