MX2015011180A - Derivados de aril sulfamida y sulfamato como moduladores del receptor huerfano relacionado con el receptor del retinoide (porc). - Google Patents
Derivados de aril sulfamida y sulfamato como moduladores del receptor huerfano relacionado con el receptor del retinoide (porc).Info
- Publication number
- MX2015011180A MX2015011180A MX2015011180A MX2015011180A MX2015011180A MX 2015011180 A MX2015011180 A MX 2015011180A MX 2015011180 A MX2015011180 A MX 2015011180A MX 2015011180 A MX2015011180 A MX 2015011180A MX 2015011180 A MX2015011180 A MX 2015011180A
- Authority
- MX
- Mexico
- Prior art keywords
- sulfamate derivatives
- aryl sulfamide
- rorc modulators
- rorc
- modulators
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/96—Sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/15—Six-membered rings
- C07D285/16—Thiadiazines; Hydrogenated thiadiazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/36—Seven-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epidemiology (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invenpción se refiere a los compuestos de la fórmula I: o las sales de los mismos farmacéuticamente aceptables, en donde m, n, p, q, r, A, X1, X2, X3, X4, X5, X6, Y, Z, G, R1a, R2a, R1b, R2b, R3, R4, R5 y R6 son como se definieron aquí. También se describen métodos de fabricación de los compuestos y el uso de los compuestos para el tratamiento de las enfermedades inflamatorias tales como la artritis.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361790271P | 2013-03-15 | 2013-03-15 | |
PCT/EP2014/054764 WO2014140059A1 (en) | 2013-03-15 | 2014-03-12 | ARYL SULFAMIDE AND SULFAMATE DERIVATIVES AS RORc MODULATORS |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2015011180A true MX2015011180A (es) | 2015-11-11 |
Family
ID=50241444
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2015011180A MX2015011180A (es) | 2013-03-15 | 2014-03-12 | Derivados de aril sulfamida y sulfamato como moduladores del receptor huerfano relacionado con el receptor del retinoide (porc). |
Country Status (11)
Country | Link |
---|---|
US (1) | US8912219B2 (es) |
EP (1) | EP2970116A1 (es) |
JP (1) | JP2016510781A (es) |
KR (1) | KR20150128863A (es) |
CN (1) | CN105121404A (es) |
BR (1) | BR112015023571A2 (es) |
CA (1) | CA2902252A1 (es) |
HK (1) | HK1218114A1 (es) |
MX (1) | MX2015011180A (es) |
RU (1) | RU2015141592A (es) |
WO (1) | WO2014140059A1 (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
LT3077372T (lt) * | 2013-12-05 | 2019-03-25 | Lead Pharma Holding B.V. | Ror gama (rory) moduliatoriai |
MX2016008721A (es) * | 2014-01-10 | 2017-01-26 | Hoffmann La Roche | Derivados de aril sultama como moduladores del receptor huerfano relacionado con acido retinoico (rorc). |
WO2017005668A1 (en) * | 2015-07-08 | 2017-01-12 | F. Hoffmann-La Roche Ag | ARYL SULTAM DERIVATIVES AS RORc MODULATORS |
EP4108659A1 (en) | 2016-06-07 | 2022-12-28 | Jacobio Pharmaceuticals Co., Ltd. | Novel heterocyclic derivatives useful as shp2 inhibitors |
AU2018239542C1 (en) | 2017-03-23 | 2021-02-11 | Jacobio Pharmaceuticals Co., Ltd. | Novel heterocyclic derivatives useful as SHP2 inhibitors |
WO2018185675A1 (en) * | 2017-04-04 | 2018-10-11 | Glenmark Pharmaceuticals S.A. | Substituted oxoazetidine analogues as ror gamma modulators |
CN111148743B (zh) | 2017-10-06 | 2023-12-15 | 福马治疗有限公司 | 抑制泛素特异性肽酶30 |
CN109896998B (zh) * | 2017-12-10 | 2022-06-07 | 复旦大学 | 一种3,4-二氢异喹啉磺酰胺类化合物及其应用 |
CA3110113A1 (en) | 2018-10-05 | 2020-04-09 | Forma Therapeutics, Inc. | Fused pyrrolines which act as ubiquitin-specific protease 30 (usp30) inhibitors |
CN113336655A (zh) * | 2020-12-30 | 2021-09-03 | 江西迪赛诺制药有限公司 | 一种(r)-3-氨基丁醇的制备方法 |
CN113013491A (zh) | 2021-03-16 | 2021-06-22 | 广州天赐高新材料股份有限公司 | 电解液添加剂、电解液及锂离子电池 |
CN113861045A (zh) * | 2021-10-25 | 2021-12-31 | 绍兴众昌化工股份有限公司 | 一种(r)-3-氨基丁醇的制备方法 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL155805A0 (en) * | 2000-12-18 | 2003-12-23 | Actelion Pharmaceuticals Ltd | Novel sulfamides and their use as endothelin receptor antagonists |
CN1646508A (zh) * | 2002-04-03 | 2005-07-27 | 诺瓦提斯公司 | 作为ptp酶1b抑制剂的5-取代的1,1-二氧代-1,2,5-噻二唑烷-3-酮衍生物 |
ATE548354T1 (de) * | 2002-07-24 | 2012-03-15 | Ptc Therapeutics Inc | Ureido-substituierte benzoesäureverbindungen und ihre verwendung für die nonsense-suppression und behandlung von erkrankungen |
DK2392564T3 (da) * | 2003-09-26 | 2014-01-13 | Exelixis Inc | c-Met-modulatorer og anvendelsesfremgangsmåder |
JP2006083137A (ja) * | 2004-09-17 | 2006-03-30 | Sankyo Co Ltd | 免疫抑制剤 |
WO2006038594A1 (ja) * | 2004-10-04 | 2006-04-13 | Ono Pharmaceutical Co., Ltd. | N型カルシウムチャネル阻害薬 |
WO2008042867A2 (en) * | 2006-09-29 | 2008-04-10 | Emiliem Inc. | Modulators of multiple kinases |
US20080261978A1 (en) * | 2007-03-08 | 2008-10-23 | Clark Michael P | Chemokine receptor modulators |
WO2010029048A1 (en) * | 2008-09-09 | 2010-03-18 | Sekmed Srl | 1, 2, 5-thiadiazole derivatives useful as immune potentiators |
AU2010243585B2 (en) * | 2009-04-30 | 2014-08-07 | AbbVie Deutschland GmbH & Co. KG | N-phenyl-(piperazinyl or homopiperazinyl)-benzenesulfonamide or benzenesulfonyl-phenyl-(piperazine or homopiperazine) compounds suitable for treating disorders that respond to modulation of the serotonin 5-HT6 receptor |
GB201002563D0 (en) * | 2010-02-15 | 2010-03-31 | Cambridge Entpr Ltd | Compounds |
WO2011115892A1 (en) * | 2010-03-15 | 2011-09-22 | Griffin Patrick R | Modulators of the retinoic acid receptor-related orphan receptors |
EP2598481B1 (en) * | 2010-07-26 | 2016-08-31 | Bristol-Myers Squibb Company | Sulfonamide compounds useful as cyp17 inhibitors |
WO2012064744A2 (en) * | 2010-11-08 | 2012-05-18 | Lycera Corporation | Tetrahydroquinoline and related bicyclic compounds for inhibition of rorϒ activity and the treatment of disease |
SG194697A1 (en) * | 2011-05-03 | 2013-12-30 | Agios Pharmaceuticals Inc | Pyruvate kinase activators for use in therapy |
WO2012158784A2 (en) * | 2011-05-16 | 2012-11-22 | Theodore Mark Kamenecka | Modulators of the nuclear hormone receptor ror |
-
2014
- 2014-03-12 KR KR1020157027861A patent/KR20150128863A/ko not_active Application Discontinuation
- 2014-03-12 EP EP14709306.6A patent/EP2970116A1/en not_active Withdrawn
- 2014-03-12 MX MX2015011180A patent/MX2015011180A/es unknown
- 2014-03-12 CA CA2902252A patent/CA2902252A1/en not_active Abandoned
- 2014-03-12 JP JP2015562102A patent/JP2016510781A/ja active Pending
- 2014-03-12 RU RU2015141592A patent/RU2015141592A/ru not_active Application Discontinuation
- 2014-03-12 BR BR112015023571A patent/BR112015023571A2/pt not_active IP Right Cessation
- 2014-03-12 WO PCT/EP2014/054764 patent/WO2014140059A1/en active Application Filing
- 2014-03-12 CN CN201480013543.5A patent/CN105121404A/zh active Pending
- 2014-03-14 US US14/210,978 patent/US8912219B2/en not_active Expired - Fee Related
-
2016
- 2016-05-31 HK HK16106170.1A patent/HK1218114A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
KR20150128863A (ko) | 2015-11-18 |
CN105121404A (zh) | 2015-12-02 |
EP2970116A1 (en) | 2016-01-20 |
US20140275032A1 (en) | 2014-09-18 |
WO2014140059A1 (en) | 2014-09-18 |
RU2015141592A (ru) | 2017-04-21 |
BR112015023571A2 (pt) | 2017-07-18 |
CA2902252A1 (en) | 2014-09-18 |
US8912219B2 (en) | 2014-12-16 |
HK1218114A1 (zh) | 2017-02-03 |
JP2016510781A (ja) | 2016-04-11 |
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