HK1218114A1 - 作為 調節劑的芳基磺酰胺和氨基磺酸衍生物 - Google Patents

作為 調節劑的芳基磺酰胺和氨基磺酸衍生物

Info

Publication number
HK1218114A1
HK1218114A1 HK16106170.1A HK16106170A HK1218114A1 HK 1218114 A1 HK1218114 A1 HK 1218114A1 HK 16106170 A HK16106170 A HK 16106170A HK 1218114 A1 HK1218114 A1 HK 1218114A1
Authority
HK
Hong Kong
Prior art keywords
rorc
modulators
sulfamate derivatives
aryl sulfamide
sulfamide
Prior art date
Application number
HK16106170.1A
Other languages
English (en)
Inventor
Van Niel Monique Bodil
Benjamin Fauber
Olivier Rene
Stuart Ward
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of HK1218114A1 publication Critical patent/HK1218114A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/96—Sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/15—Six-membered rings
    • C07D285/16—Thiadiazines; Hydrogenated thiadiazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/36—Seven-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epidemiology (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
HK16106170.1A 2013-03-15 2016-05-31 作為 調節劑的芳基磺酰胺和氨基磺酸衍生物 HK1218114A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361790271P 2013-03-15 2013-03-15
PCT/EP2014/054764 WO2014140059A1 (en) 2013-03-15 2014-03-12 ARYL SULFAMIDE AND SULFAMATE DERIVATIVES AS RORc MODULATORS

Publications (1)

Publication Number Publication Date
HK1218114A1 true HK1218114A1 (zh) 2017-02-03

Family

ID=50241444

Family Applications (1)

Application Number Title Priority Date Filing Date
HK16106170.1A HK1218114A1 (zh) 2013-03-15 2016-05-31 作為 調節劑的芳基磺酰胺和氨基磺酸衍生物

Country Status (11)

Country Link
US (1) US8912219B2 (zh)
EP (1) EP2970116A1 (zh)
JP (1) JP2016510781A (zh)
KR (1) KR20150128863A (zh)
CN (1) CN105121404A (zh)
BR (1) BR112015023571A2 (zh)
CA (1) CA2902252A1 (zh)
HK (1) HK1218114A1 (zh)
MX (1) MX2015011180A (zh)
RU (1) RU2015141592A (zh)
WO (1) WO2014140059A1 (zh)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2014359324B2 (en) * 2013-12-05 2019-02-21 Lead Pharma Holding B.V. ROR gamma (RORy) modulators
CN105899507B (zh) * 2014-01-10 2019-06-07 豪夫迈·罗氏有限公司 作为RORc调节剂的芳基磺内酰胺衍生物
WO2017005668A1 (en) * 2015-07-08 2017-01-12 F. Hoffmann-La Roche Ag ARYL SULTAM DERIVATIVES AS RORc MODULATORS
CA3026784A1 (en) 2016-06-07 2017-12-14 Jacobio Pharmaceuticals Co., Ltd. Heterocyclic pyrazine derivatives useful as shp2 inhibitors
KR20210130254A (ko) 2017-03-23 2021-10-29 자코바이오 파마슈티칼스 컴퍼니 리미티드 Shp2 억제제로서 유용한 신규한 헤테로환형 유도체
WO2018185675A1 (en) * 2017-04-04 2018-10-11 Glenmark Pharmaceuticals S.A. Substituted oxoazetidine analogues as ror gamma modulators
EA202090871A1 (ru) 2017-10-06 2020-07-03 Форма Терапьютикс, Инк. Ингибирование убиквитин-специфической пептидазы 30
CN109896998B (zh) * 2017-12-10 2022-06-07 复旦大学 一种3,4-二氢异喹啉磺酰胺类化合物及其应用
EP4218934A1 (en) 2018-10-05 2023-08-02 Forma Therapeutics, Inc. Inhibiting ubiquitin-specific protease 30 (usp30)
CN113336655A (zh) * 2020-12-30 2021-09-03 江西迪赛诺制药有限公司 一种(r)-3-氨基丁醇的制备方法
CN113013491A (zh) 2021-03-16 2021-06-22 广州天赐高新材料股份有限公司 电解液添加剂、电解液及锂离子电池

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7094781B2 (en) * 2000-12-18 2006-08-22 Actelion Pharmaceuticals Ltd. Sulfamides and their use as endothelin receptor antagonists
PT1492780E (pt) * 2002-04-03 2012-04-11 Novartis Ag Derivados 5-substituídos de 1,1-dioxo-1,2,5-tiazolidina-3- -ona como inibidores de ptpase 1b
AU2003256755A1 (en) * 2002-07-24 2004-02-09 Ptc Therapeutics, Inc. Ureido substituted benzoic acid compounds, their use for nonsense suppression and the treatment of diseases caused by such mutations
ES2371383T3 (es) * 2003-09-26 2011-12-30 Exelixis, Inc. N-[3-fluoro-4-({6-(metiloxi)-7-[(3-morfolin-4-ilpropil)oxi]quinolin-4-il}oxi)fenil]-n'-(4-fluorofenil)ciclopropan-1,1-dicarboxamida para el tratamiento del cáncer.
JP2006083137A (ja) * 2004-09-17 2006-03-30 Sankyo Co Ltd 免疫抑制剤
WO2006038594A1 (ja) * 2004-10-04 2006-04-13 Ono Pharmaceutical Co., Ltd. Ｎ型カルシウムチャネル阻害薬
WO2008042867A2 (en) * 2006-09-29 2008-04-10 Emiliem Inc. Modulators of multiple kinases
WO2008109154A1 (en) * 2007-03-08 2008-09-12 Altiris Therapeutics, Inc. Chemokine receptor modulators
WO2010029048A1 (en) * 2008-09-09 2010-03-18 Sekmed Srl 1, 2, 5-thiadiazole derivatives useful as immune potentiators
PE20120881A1 (es) * 2009-04-30 2012-08-24 AbbVie Deutschland GmbH and Co KG Compuestos de n-fenil-(piperazinil u homopiperazinil)-bencensulfonamida o bencensulfonil-fenil-(piperazina u homopiperazina) como moduladores del receptor de serotonina 5-ht6
GB201002563D0 (en) * 2010-02-15 2010-03-31 Cambridge Entpr Ltd Compounds
WO2011115892A1 (en) * 2010-03-15 2011-09-22 Griffin Patrick R Modulators of the retinoic acid receptor-related orphan receptors
CN103209960A (zh) * 2010-07-26 2013-07-17 百时美施贵宝公司 用作cyp17抑制剂的磺酰胺化合物
EP2638014B1 (en) * 2010-11-08 2017-01-04 Lycera Corporation N-sulfonylated tetrahydroquinolines and related bicyclic compounds for inhibition of ror-gamma activity and the treatment of diseases
RU2675656C2 (ru) * 2011-05-03 2018-12-21 Аджиос Фармасьютикалз, Инк. Способы применения активаторов пируваткиназы
US9586928B2 (en) * 2011-05-16 2017-03-07 The Scripps Research Institute Modulators of the nuclear hormone receptor ROR

Also Published As

Publication number Publication date
EP2970116A1 (en) 2016-01-20
RU2015141592A (ru) 2017-04-21
CN105121404A (zh) 2015-12-02
CA2902252A1 (en) 2014-09-18
WO2014140059A1 (en) 2014-09-18
BR112015023571A2 (pt) 2017-07-18
US20140275032A1 (en) 2014-09-18
JP2016510781A (ja) 2016-04-11
KR20150128863A (ko) 2015-11-18
MX2015011180A (es) 2015-11-11
US8912219B2 (en) 2014-12-16

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