CN102574818B - Apaf-1抑制剂化合物 - Google Patents

Apaf-1抑制剂化合物 Download PDF

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Publication number
CN102574818B
CN102574818B CN201080043254.1A CN201080043254A CN102574818B CN 102574818 B CN102574818 B CN 102574818B CN 201080043254 A CN201080043254 A CN 201080043254A CN 102574818 B CN102574818 B CN 102574818B
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aryl
ethyl
alkyl
compound according
heteroaryl
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Expired - Fee Related
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CN102574818A (zh
Inventor
安赫尔·梅塞盖尔·佩波
亚历杭德拉·莫雷·费尔南德斯
丹尼尔·冈萨雷斯·皮纳乔
伊莎贝尔·马西普·马西普
恩里克·法勒斯·帕亚
纳蒂夫达德·加西亚·维勒
埃斯特尔·蒙洛里奥·马斯
朱瓦洛·卡泰纳·鲁伊斯
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Spiral Diagnosis And Treatment Co ltd
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Laboratorios Salvat SA
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P27/00—Drugs for disorders of the senses
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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CN201080043254.1A 2009-07-30 2010-07-29 Apaf-1抑制剂化合物 Expired - Fee Related CN102574818B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ES200901757 2009-07-30
ESP200901757 2009-07-30
PCT/ES2010/000349 WO2011012746A2 (es) 2009-07-30 2010-07-29 Compuestos inhibidores de apaf-1

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CN102574818A CN102574818A (zh) 2012-07-11
CN102574818B true CN102574818B (zh) 2015-02-25

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US (1) US9040701B2 (https=)
EP (1) EP2460798B1 (https=)
JP (1) JP5694320B2 (https=)
KR (1) KR101786761B1 (https=)
CN (1) CN102574818B (https=)
AU (1) AU2010277505B2 (https=)
BR (1) BR112012002134B8 (https=)
CA (1) CA2769408C (https=)
EA (1) EA021838B1 (https=)
ES (1) ES2727711T3 (https=)
IN (1) IN2012DN01378A (https=)
MX (1) MX2012001339A (https=)
NZ (1) NZ598125A (https=)
TR (1) TR201907804T4 (https=)
WO (1) WO2011012746A2 (https=)

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KR20120052354A (ko) 2012-05-23
US20120122868A1 (en) 2012-05-17
BR112012002134A2 (pt) 2016-05-31
KR101786761B1 (ko) 2017-10-18
US9040701B2 (en) 2015-05-26
AU2010277505B2 (en) 2016-01-14
WO2011012746A3 (es) 2011-07-14
MX2012001339A (es) 2012-03-07
JP2013500314A (ja) 2013-01-07
JP5694320B2 (ja) 2015-04-01
EA021838B1 (ru) 2015-09-30
AU2010277505A1 (en) 2012-03-08
EA201270215A1 (ru) 2012-11-30
ES2727711T3 (es) 2019-10-18
WO2011012746A2 (es) 2011-02-03
BR112012002134B8 (pt) 2021-05-25
CA2769408A1 (en) 2011-02-03
NZ598125A (en) 2014-05-30
IN2012DN01378A (https=) 2015-06-05
BR112012002134B1 (pt) 2021-03-02
EP2460798A4 (en) 2013-02-27
CN102574818A (zh) 2012-07-11
EP2460798A2 (en) 2012-06-06
CA2769408C (en) 2017-09-05
EP2460798B1 (en) 2019-02-27

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