CN102256595A - 制备小粒径脂质体的方法 - Google Patents

制备小粒径脂质体的方法 Download PDF

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Publication number
CN102256595A
CN102256595A CN2009801509533A CN200980150953A CN102256595A CN 102256595 A CN102256595 A CN 102256595A CN 2009801509533 A CN2009801509533 A CN 2009801509533A CN 200980150953 A CN200980150953 A CN 200980150953A CN 102256595 A CN102256595 A CN 102256595A
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CN
China
Prior art keywords
flow rate
organic solvent
water
stream
lipid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2009801509533A
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English (en)
Chinese (zh)
Inventor
R·A·迪皮
W·J·赖利
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cascadian Therapeutics Inc
Original Assignee
Oncothyreon Inc
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Filing date
Publication date
Application filed by Oncothyreon Inc filed Critical Oncothyreon Inc
Priority to CN201610381865.6A priority Critical patent/CN105935352A/zh
Publication of CN102256595A publication Critical patent/CN102256595A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/775—Apolipopeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A61K38/1735—Mucins, e.g. human intestinal mucin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Dispersion Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN2009801509533A 2008-12-17 2009-12-17 制备小粒径脂质体的方法 Pending CN102256595A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201610381865.6A CN105935352A (zh) 2008-12-17 2009-12-17 制备小粒径脂质体的方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13835308P 2008-12-17 2008-12-17
US61/138353 2008-12-17
PCT/US2009/068499 WO2010078045A2 (en) 2008-12-17 2009-12-17 Method of making small liposomes

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201610381865.6A Division CN105935352A (zh) 2008-12-17 2009-12-17 制备小粒径脂质体的方法

Publications (1)

Publication Number Publication Date
CN102256595A true CN102256595A (zh) 2011-11-23

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Family Applications (2)

Application Number Title Priority Date Filing Date
CN2009801509533A Pending CN102256595A (zh) 2008-12-17 2009-12-17 制备小粒径脂质体的方法
CN201610381865.6A Pending CN105935352A (zh) 2008-12-17 2009-12-17 制备小粒径脂质体的方法

Family Applications After (1)

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CN201610381865.6A Pending CN105935352A (zh) 2008-12-17 2009-12-17 制备小粒径脂质体的方法

Country Status (12)

Country Link
US (3) US20120034294A1 (enExample)
EP (1) EP2367532A4 (enExample)
JP (2) JP2012512260A (enExample)
KR (1) KR101452033B1 (enExample)
CN (2) CN102256595A (enExample)
AU (1) AU2009333177B2 (enExample)
BR (1) BRPI0923001A2 (enExample)
CA (1) CA2747182C (enExample)
EA (1) EA020604B1 (enExample)
MX (1) MX2011006562A (enExample)
SG (1) SG172257A1 (enExample)
WO (1) WO2010078045A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110520214A (zh) * 2017-04-13 2019-11-29 国立大学法人北海道大学 流路构造体及使用其的脂质粒子或微胞的形成方法

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI395591B (zh) * 2004-04-01 2013-05-11 Oncothyreon Inc 黏液性糖蛋白（ｍｕｃ-１）疫苗
JP5771366B2 (ja) * 2009-09-02 2015-08-26 株式会社バイオメッドコア リポソーム製造装置及び方法
KR20140023903A (ko) 2011-02-24 2014-02-27 온코타이레온, 인코포레이티드 항원보강제를 갖는 muc1 기초 당지질펩티드 백신
KR101387575B1 (ko) * 2012-08-10 2014-04-23 서울대학교산학협력단 인지질 및 아세틸렌기를 포함하는 리포좀 및 그의 용도
US9693958B2 (en) * 2013-03-15 2017-07-04 Cureport, Inc. Methods and devices for preparation of lipid nanoparticles
AU2014329547B2 (en) * 2013-10-02 2019-05-16 The Board Of Trustees Of The Leland Stanford Junior University Wnt compositions and methods for purification
CN107427791B (zh) * 2015-03-19 2021-05-14 康涅狄格大学 用于连续制造脂质体药物制剂的系统和方法
EP3711749A1 (en) * 2019-03-19 2020-09-23 Polymun Scientific Immunbiologische Forschung GmbH Method of making lipid nanoparticles
US11737979B2 (en) 2019-03-19 2023-08-29 Arcturus Therapeutics, Inc. Method of making lipid-encapsulated RNA nanoparticles
WO2023041588A1 (en) 2021-09-14 2023-03-23 Advapharm Gmbh Novel lipopeptide formulation

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050112184A1 (en) * 2003-11-26 2005-05-26 Andreas Jahn Controlled vesicle self-assembly in continuous two phase flow microfluidic channels
CN1674870A (zh) * 2002-06-21 2005-09-28 皮埃蒙特医药品有限公司 含有生物活性化合物的脂质体
CN101267805A (zh) * 2005-07-27 2008-09-17 普洛体维生物治疗公司 制造脂质体的系统和方法
CN101309697A (zh) * 2005-06-28 2008-11-19 拜奥米拉公司 用一种粘蛋白状糖蛋白(muc-1)疫苗治疗患者的方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11139961A (ja) * 1997-11-06 1999-05-25 Taisho Pharmaceut Co Ltd リポソームの製造方法
JP2002509102A (ja) * 1998-01-16 2002-03-26 バイオミラ・ユーエスエイ・インコーポレイテッド リポマトリックス製剤
AU771706B2 (en) * 1999-07-15 2004-04-01 University Of British Columbia, The Methods and apparatus for preparation of lipid vesicles
WO2001036433A2 (en) * 1999-11-15 2001-05-25 Biomira, Inc. Synthetic lipid-a analogs and uses thereof
EP1343476B1 (en) * 2000-12-01 2008-05-28 Biomira Inc. Preparation of large liposomes by infusion into peg
WO2004071638A2 (en) * 2003-02-11 2004-08-26 Regents Of The University Of California, The Microfluidic devices and method for controlled viscous shearing and formation of amphiphilic vesicles
TWI395591B (zh) * 2004-04-01 2013-05-11 Oncothyreon Inc 黏液性糖蛋白（ｍｕｃ-１）疫苗
CA2596131A1 (en) * 2005-01-28 2006-08-03 Bc Cancer Agency Liposomal compositions for parenteral delivery of agents
EP2012750B1 (en) * 2006-04-06 2018-02-21 Insmed Incorporated Methods for coacervation induced liposomal encapsulation and formulations thereof
US7811603B2 (en) * 2006-05-09 2010-10-12 The Regents Of The University Of California Microfluidic device for forming monodisperse lipoplexes
JP5126874B2 (ja) * 2007-05-21 2013-01-23 国立大学法人神戸大学 リポソーム製剤の製造方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1674870A (zh) * 2002-06-21 2005-09-28 皮埃蒙特医药品有限公司 含有生物活性化合物的脂质体
US20050112184A1 (en) * 2003-11-26 2005-05-26 Andreas Jahn Controlled vesicle self-assembly in continuous two phase flow microfluidic channels
CN101309697A (zh) * 2005-06-28 2008-11-19 拜奥米拉公司 用一种粘蛋白状糖蛋白(muc-1)疫苗治疗患者的方法
CN101267805A (zh) * 2005-07-27 2008-09-17 普洛体维生物治疗公司 制造脂质体的系统和方法

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110520214A (zh) * 2017-04-13 2019-11-29 国立大学法人北海道大学 流路构造体及使用其的脂质粒子或微胞的形成方法

Also Published As

Publication number Publication date
EP2367532A4 (en) 2012-12-12
KR101452033B1 (ko) 2014-10-21
WO2010078045A2 (en) 2010-07-08
EP2367532A2 (en) 2011-09-28
CN105935352A (zh) 2016-09-14
BRPI0923001A2 (pt) 2018-09-18
US20120034294A1 (en) 2012-02-09
WO2010078045A3 (en) 2010-10-28
CA2747182A1 (en) 2010-07-08
JP2012512260A (ja) 2012-05-31
SG172257A1 (en) 2011-07-28
JP5895030B2 (ja) 2016-03-30
MX2011006562A (es) 2011-09-27
US20150315217A1 (en) 2015-11-05
AU2009333177A1 (en) 2011-07-07
KR20110094114A (ko) 2011-08-19
JP2014224127A (ja) 2014-12-04
CA2747182C (en) 2014-11-18
EA201100829A1 (ru) 2012-02-28
EA020604B1 (ru) 2014-12-30
US20130330398A1 (en) 2013-12-12
AU2009333177B2 (en) 2013-09-19

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Application publication date: 20111123