AU2009333177B2 - Method of making small liposomes - Google Patents

Method of making small liposomes Download PDF

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Publication number
AU2009333177B2
AU2009333177B2 AU2009333177A AU2009333177A AU2009333177B2 AU 2009333177 B2 AU2009333177 B2 AU 2009333177B2 AU 2009333177 A AU2009333177 A AU 2009333177A AU 2009333177 A AU2009333177 A AU 2009333177A AU 2009333177 B2 AU2009333177 B2 AU 2009333177B2
Authority
AU
Australia
Prior art keywords
liposomes
stream
water
composition according
organic solvent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2009333177A
Other languages
English (en)
Other versions
AU2009333177A1 (en
Inventor
Robert A. Dupuit
William J. Reilley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cascadian Therapeutics Inc
Original Assignee
Oncothyreon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncothyreon Inc filed Critical Oncothyreon Inc
Publication of AU2009333177A1 publication Critical patent/AU2009333177A1/en
Application granted granted Critical
Publication of AU2009333177B2 publication Critical patent/AU2009333177B2/en
Priority to AU2013273711A priority Critical patent/AU2013273711B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/775—Apolipopeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A61K38/1735—Mucins, e.g. human intestinal mucin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
AU2009333177A 2008-12-17 2009-12-17 Method of making small liposomes Ceased AU2009333177B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2013273711A AU2013273711B2 (en) 2008-12-17 2013-12-19 Method of making small liposomes

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13835308P 2008-12-17 2008-12-17
US61/138,353 2008-12-17
PCT/US2009/068499 WO2010078045A2 (en) 2008-12-17 2009-12-17 Method of making small liposomes

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2013273711A Division AU2013273711B2 (en) 2008-12-17 2013-12-19 Method of making small liposomes

Publications (2)

Publication Number Publication Date
AU2009333177A1 AU2009333177A1 (en) 2011-07-07
AU2009333177B2 true AU2009333177B2 (en) 2013-09-19

Family

ID=42310550

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2009333177A Ceased AU2009333177B2 (en) 2008-12-17 2009-12-17 Method of making small liposomes

Country Status (12)

Country Link
US (3) US20120034294A1 (enExample)
EP (1) EP2367532A4 (enExample)
JP (2) JP2012512260A (enExample)
KR (1) KR101452033B1 (enExample)
CN (2) CN102256595A (enExample)
AU (1) AU2009333177B2 (enExample)
BR (1) BRPI0923001A2 (enExample)
CA (1) CA2747182C (enExample)
EA (1) EA020604B1 (enExample)
MX (1) MX2011006562A (enExample)
SG (1) SG172257A1 (enExample)
WO (1) WO2010078045A2 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI395591B (zh) * 2004-04-01 2013-05-11 Oncothyreon Inc 黏液性糖蛋白（ｍｕｃ-１）疫苗
JP5771366B2 (ja) * 2009-09-02 2015-08-26 株式会社バイオメッドコア リポソーム製造装置及び方法
KR20140023903A (ko) 2011-02-24 2014-02-27 온코타이레온, 인코포레이티드 항원보강제를 갖는 muc1 기초 당지질펩티드 백신
KR101387575B1 (ko) * 2012-08-10 2014-04-23 서울대학교산학협력단 인지질 및 아세틸렌기를 포함하는 리포좀 및 그의 용도
US9693958B2 (en) * 2013-03-15 2017-07-04 Cureport, Inc. Methods and devices for preparation of lipid nanoparticles
AU2014329547B2 (en) * 2013-10-02 2019-05-16 The Board Of Trustees Of The Leland Stanford Junior University Wnt compositions and methods for purification
CN107427791B (zh) * 2015-03-19 2021-05-14 康涅狄格大学 用于连续制造脂质体药物制剂的系统和方法
EP3610943B1 (en) * 2017-04-13 2023-05-31 National University Corporation Hokkaido University Flow channel structure and lipid particle or micelle formation method using same
EP3711749A1 (en) * 2019-03-19 2020-09-23 Polymun Scientific Immunbiologische Forschung GmbH Method of making lipid nanoparticles
US11737979B2 (en) 2019-03-19 2023-08-29 Arcturus Therapeutics, Inc. Method of making lipid-encapsulated RNA nanoparticles
WO2023041588A1 (en) 2021-09-14 2023-03-23 Advapharm Gmbh Novel lipopeptide formulation

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050112184A1 (en) * 2003-11-26 2005-05-26 Andreas Jahn Controlled vesicle self-assembly in continuous two phase flow microfluidic channels

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11139961A (ja) * 1997-11-06 1999-05-25 Taisho Pharmaceut Co Ltd リポソームの製造方法
JP2002509102A (ja) * 1998-01-16 2002-03-26 バイオミラ・ユーエスエイ・インコーポレイテッド リポマトリックス製剤
AU771706B2 (en) * 1999-07-15 2004-04-01 University Of British Columbia, The Methods and apparatus for preparation of lipid vesicles
WO2001036433A2 (en) * 1999-11-15 2001-05-25 Biomira, Inc. Synthetic lipid-a analogs and uses thereof
EP1343476B1 (en) * 2000-12-01 2008-05-28 Biomira Inc. Preparation of large liposomes by infusion into peg
US20030235610A1 (en) * 2002-06-21 2003-12-25 Piedmont Pharmaceuticals, Llc Liposomes containing biologically active compounds
WO2004071638A2 (en) * 2003-02-11 2004-08-26 Regents Of The University Of California, The Microfluidic devices and method for controlled viscous shearing and formation of amphiphilic vesicles
TWI395591B (zh) * 2004-04-01 2013-05-11 Oncothyreon Inc 黏液性糖蛋白（ｍｕｃ-１）疫苗
CA2596131A1 (en) * 2005-01-28 2006-08-03 Bc Cancer Agency Liposomal compositions for parenteral delivery of agents
ES2526344T3 (es) * 2005-06-28 2015-01-09 Oncothyreon Inc. Método para el tratamiento de pacientes con una vacuna de glicoproteína mucinosa (MUC-1)
JP5639338B2 (ja) * 2005-07-27 2014-12-10 プロチバ バイオセラピューティクス インコーポレイティッド リポソームの製造システムおよび製造方法
EP2012750B1 (en) * 2006-04-06 2018-02-21 Insmed Incorporated Methods for coacervation induced liposomal encapsulation and formulations thereof
US7811603B2 (en) * 2006-05-09 2010-10-12 The Regents Of The University Of California Microfluidic device for forming monodisperse lipoplexes
JP5126874B2 (ja) * 2007-05-21 2013-01-23 国立大学法人神戸大学 リポソーム製剤の製造方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050112184A1 (en) * 2003-11-26 2005-05-26 Andreas Jahn Controlled vesicle self-assembly in continuous two phase flow microfluidic channels

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Jahn, A. et al., Langmuir, 2007, vol. 23, pp. 6289-6293 *

Also Published As

Publication number Publication date
EP2367532A4 (en) 2012-12-12
KR101452033B1 (ko) 2014-10-21
WO2010078045A2 (en) 2010-07-08
EP2367532A2 (en) 2011-09-28
CN105935352A (zh) 2016-09-14
BRPI0923001A2 (pt) 2018-09-18
US20120034294A1 (en) 2012-02-09
WO2010078045A3 (en) 2010-10-28
CA2747182A1 (en) 2010-07-08
CN102256595A (zh) 2011-11-23
JP2012512260A (ja) 2012-05-31
SG172257A1 (en) 2011-07-28
JP5895030B2 (ja) 2016-03-30
MX2011006562A (es) 2011-09-27
US20150315217A1 (en) 2015-11-05
AU2009333177A1 (en) 2011-07-07
KR20110094114A (ko) 2011-08-19
JP2014224127A (ja) 2014-12-04
CA2747182C (en) 2014-11-18
EA201100829A1 (ru) 2012-02-28
EA020604B1 (ru) 2014-12-30
US20130330398A1 (en) 2013-12-12

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FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired