JP2012512260A - 小さなリポソームの製造方法 - Google Patents

小さなリポソームの製造方法 Download PDF

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JP2012512260A
JP2012512260A JP2011542440A JP2011542440A JP2012512260A JP 2012512260 A JP2012512260 A JP 2012512260A JP 2011542440 A JP2011542440 A JP 2011542440A JP 2011542440 A JP2011542440 A JP 2011542440A JP 2012512260 A JP2012512260 A JP 2012512260A
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flow rate
organic solvent
water
liposomes
lipid
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JP2012512260A5 (enExample
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ロバート エイ． デュピュイ
ウィリアム ジェイ． レイリー
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オンコセリオン インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/775—Apolipopeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A61K38/1735—Mucins, e.g. human intestinal mucin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
JP2011542440A 2008-12-17 2009-12-17 小さなリポソームの製造方法 Pending JP2012512260A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13835308P 2008-12-17 2008-12-17
US61/138,353 2008-12-17
PCT/US2009/068499 WO2010078045A2 (en) 2008-12-17 2009-12-17 Method of making small liposomes

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2014143840A Division JP5895030B2 (ja) 2008-12-17 2014-07-14 小さなリポソームの製造方法

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JP2012512260A true JP2012512260A (ja) 2012-05-31
JP2012512260A5 JP2012512260A5 (enExample) 2012-08-30

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JP2011542440A Pending JP2012512260A (ja) 2008-12-17 2009-12-17 小さなリポソームの製造方法
JP2014143840A Expired - Fee Related JP5895030B2 (ja) 2008-12-17 2014-07-14 小さなリポソームの製造方法

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US (3) US20120034294A1 (enExample)
EP (1) EP2367532A4 (enExample)
JP (2) JP2012512260A (enExample)
KR (1) KR101452033B1 (enExample)
CN (2) CN102256595A (enExample)
AU (1) AU2009333177B2 (enExample)
BR (1) BRPI0923001A2 (enExample)
CA (1) CA2747182C (enExample)
EA (1) EA020604B1 (enExample)
MX (1) MX2011006562A (enExample)
SG (1) SG172257A1 (enExample)
WO (1) WO2010078045A2 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011072985A (ja) * 2009-09-02 2011-04-14 Biomedcore Inc リポソーム製造装置及び方法
JP2017501207A (ja) * 2013-10-02 2017-01-12 ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ Ｗｎｔ組成物および精製方法

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI395591B (zh) * 2004-04-01 2013-05-11 Oncothyreon Inc 黏液性糖蛋白（ｍｕｃ-１）疫苗
KR20140023903A (ko) 2011-02-24 2014-02-27 온코타이레온, 인코포레이티드 항원보강제를 갖는 muc1 기초 당지질펩티드 백신
KR101387575B1 (ko) * 2012-08-10 2014-04-23 서울대학교산학협력단 인지질 및 아세틸렌기를 포함하는 리포좀 및 그의 용도
US9693958B2 (en) * 2013-03-15 2017-07-04 Cureport, Inc. Methods and devices for preparation of lipid nanoparticles
CN107427791B (zh) * 2015-03-19 2021-05-14 康涅狄格大学 用于连续制造脂质体药物制剂的系统和方法
EP3610943B1 (en) * 2017-04-13 2023-05-31 National University Corporation Hokkaido University Flow channel structure and lipid particle or micelle formation method using same
EP3711749A1 (en) * 2019-03-19 2020-09-23 Polymun Scientific Immunbiologische Forschung GmbH Method of making lipid nanoparticles
US11737979B2 (en) 2019-03-19 2023-08-29 Arcturus Therapeutics, Inc. Method of making lipid-encapsulated RNA nanoparticles
WO2023041588A1 (en) 2021-09-14 2023-03-23 Advapharm Gmbh Novel lipopeptide formulation

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11139961A (ja) * 1997-11-06 1999-05-25 Taisho Pharmaceut Co Ltd リポソームの製造方法
JP2002509102A (ja) * 1998-01-16 2002-03-26 バイオミラ・ユーエスエイ・インコーポレイテッド リポマトリックス製剤
JP2003514824A (ja) * 1999-11-15 2003-04-22 ビオミラ，インコーポレーテッド 合成脂質−ａ類似体およびその使用
WO2004071638A2 (en) * 2003-02-11 2004-08-26 Regents Of The University Of California, The Microfluidic devices and method for controlled viscous shearing and formation of amphiphilic vesicles
JP2005536481A (ja) * 2002-06-21 2005-12-02 ピードモント ファーマシューティカルズ エルエルシー 生物学的活性物質を含むリポソーム
JP2007530663A (ja) * 2004-04-01 2007-11-01 バイオミラ インコーポレイティッド ムチン糖タンパク質（ｍｕｃ−１）ワクチン

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU771706B2 (en) * 1999-07-15 2004-04-01 University Of British Columbia, The Methods and apparatus for preparation of lipid vesicles
EP1343476B1 (en) * 2000-12-01 2008-05-28 Biomira Inc. Preparation of large liposomes by infusion into peg
US9198645B2 (en) * 2003-11-26 2015-12-01 The United States of America, as represented by the Secretary of Commerce of The National Institute of Standards and Technology Controlled vesicle self-assembly in continuous two phase flow microfluidic channels
CA2596131A1 (en) * 2005-01-28 2006-08-03 Bc Cancer Agency Liposomal compositions for parenteral delivery of agents
ES2526344T3 (es) * 2005-06-28 2015-01-09 Oncothyreon Inc. Método para el tratamiento de pacientes con una vacuna de glicoproteína mucinosa (MUC-1)
JP5639338B2 (ja) * 2005-07-27 2014-12-10 プロチバ バイオセラピューティクス インコーポレイティッド リポソームの製造システムおよび製造方法
EP2012750B1 (en) * 2006-04-06 2018-02-21 Insmed Incorporated Methods for coacervation induced liposomal encapsulation and formulations thereof
US7811603B2 (en) * 2006-05-09 2010-10-12 The Regents Of The University Of California Microfluidic device for forming monodisperse lipoplexes
JP5126874B2 (ja) * 2007-05-21 2013-01-23 国立大学法人神戸大学 リポソーム製剤の製造方法

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11139961A (ja) * 1997-11-06 1999-05-25 Taisho Pharmaceut Co Ltd リポソームの製造方法
JP2002509102A (ja) * 1998-01-16 2002-03-26 バイオミラ・ユーエスエイ・インコーポレイテッド リポマトリックス製剤
JP2003514824A (ja) * 1999-11-15 2003-04-22 ビオミラ，インコーポレーテッド 合成脂質−ａ類似体およびその使用
JP2005536481A (ja) * 2002-06-21 2005-12-02 ピードモント ファーマシューティカルズ エルエルシー 生物学的活性物質を含むリポソーム
WO2004071638A2 (en) * 2003-02-11 2004-08-26 Regents Of The University Of California, The Microfluidic devices and method for controlled viscous shearing and formation of amphiphilic vesicles
JP2007530663A (ja) * 2004-04-01 2007-11-01 バイオミラ インコーポレイティッド ムチン糖タンパク質（ｍｕｃ−１）ワクチン

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
JPN7013001565; ＪＡＨＮ　ｅｔ　ａｌ．: 'Ｍｉｃｒｏｆｌｕｉｄｉｃ　ｄｉｒｅｃｔｅｄ　ｆｏｒｍａｔｉｏｎ　ｏｆ　ｌｉｐｏｓｏｍｅｓ　ｏｆ　ｃｏｎｔｒｏｌｌｅｄ　ｓｉｚｅ' ＬＡＮＧＭＵＩＲ，　２００７ ｖｏｌ．　２３，　ｎｏ．　１１, 2007, ｐｐ　６２８９　-　６２９３ *
JPN7013001566; ＪＡＨＮ　ｅｔ　ａｌ．: 'Ｐｒｅｐａｒａｔｉｏｎ　ｏｆ　ｎａｎｏｐａｒｔｉｃｌｅｓ　ｂｙ　ｃｏｎｔｉｎｕｏｕｓ-ｆｌｏｗ　ｍｉｃｒｏｆｌｕｉｄｉｃｓ' Ｊｏｕｒｎａｌ　ｏｆ　ｎａｎｏｐａｒｔｉｃｌｅ　ｒｅｓｅａｒｃｈ，　２００８ ｖｏｌ．　１０，　ｎｏ．　６, 2008, ｐｐ　９２５-９３４ *
JPN7013001567; ＰＲＡＤＨＡＮ　ｅｔ　ａｌ．: 'Ａ　Ｆａｃｉｌｅ　Ｍｉｃｒｏｆｌｕｉｄｉｃ　Ｍｅｔｈｏｄ　ｆｏｒ　Ｐｒｏｄｕｃｔｉｏｎ　ｏｆ　Ｌｉｐｏｓｏｍｅｓ' Ａｎｔｉｃａｎｃｅｒ　ｒｅｓｅａｒｃｈ，　２００８ ｖｏｌ．　２８, 2008, ｐｐ　９４３-９４７ *
JPN7013001568; ＪＡＨＮ　ｅｔ　ａｌ．: 'Ｃｏｎｔｒｏｌｌｅｄ　Ｖｅｓｉｃｌｅ　Ｓｅｌｆ-Ａｓｓｅｍｂｌｙ　ｉｎ　Ｍｉｃｒｏｆｌｕｄｉｃ　Ｃｈａｎｎｅｌｓ　ｗｉｔｈ　Ｈｙｄｒｏｄｙｎａｍｉｃ　Ｆｏｃｕｓｉｎｇ' Ｊｏｕｒｎａｌ　ｏｆ　ｔｈｅ　ａｍｅｒｉｃａｎ　ｃｈｅｍｉｃａｌ　ｓｏｃｉｅｔｙ，　２００４ ｖｏｌ．　１２６，　ｎｏ．　９, 2004, ｐｐ　２６７４-２６７５ *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011072985A (ja) * 2009-09-02 2011-04-14 Biomedcore Inc リポソーム製造装置及び方法
JP2017501207A (ja) * 2013-10-02 2017-01-12 ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ Ｗｎｔ組成物および精製方法
JP2019206551A (ja) * 2013-10-02 2019-12-05 ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォードジュニア ユニバーシティ Ｗｎｔ組成物および精製方法

Also Published As

Publication number Publication date
EP2367532A4 (en) 2012-12-12
KR101452033B1 (ko) 2014-10-21
WO2010078045A2 (en) 2010-07-08
EP2367532A2 (en) 2011-09-28
CN105935352A (zh) 2016-09-14
BRPI0923001A2 (pt) 2018-09-18
US20120034294A1 (en) 2012-02-09
WO2010078045A3 (en) 2010-10-28
CA2747182A1 (en) 2010-07-08
CN102256595A (zh) 2011-11-23
SG172257A1 (en) 2011-07-28
JP5895030B2 (ja) 2016-03-30
MX2011006562A (es) 2011-09-27
US20150315217A1 (en) 2015-11-05
AU2009333177A1 (en) 2011-07-07
KR20110094114A (ko) 2011-08-19
JP2014224127A (ja) 2014-12-04
CA2747182C (en) 2014-11-18
EA201100829A1 (ru) 2012-02-28
EA020604B1 (ru) 2014-12-30
US20130330398A1 (en) 2013-12-12
AU2009333177B2 (en) 2013-09-19

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