MX2011006562A - Metodo para elaborar liposomas pequeños. - Google Patents

Metodo para elaborar liposomas pequeños.

Info

Publication number
MX2011006562A
MX2011006562A MX2011006562A MX2011006562A MX2011006562A MX 2011006562 A MX2011006562 A MX 2011006562A MX 2011006562 A MX2011006562 A MX 2011006562A MX 2011006562 A MX2011006562 A MX 2011006562A MX 2011006562 A MX2011006562 A MX 2011006562A
Authority
MX
Mexico
Prior art keywords
liposomes
making small
stream
cooling
mixture
Prior art date
Application number
MX2011006562A
Other languages
English (en)
Inventor
Robert A Dupuit
William J Reilley
Original Assignee
Oncothyreon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncothyreon Inc filed Critical Oncothyreon Inc
Publication of MX2011006562A publication Critical patent/MX2011006562A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/775—Apolipopeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A61K38/1735—Mucins, e.g. human intestinal mucin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Los liposomas de tamaño de partícula limitado se preparan al mezclar sustancialmente continuamente corrientes de flujo sustancialmente continuas de agua, y de un disolvente orgánico contiene lípidos capaces de formar liposomas, y enfriar la mezcla ya que los liposomas que forman, la relación del índice de flujo de la corriente de agua al índice de flujo de la corriente de disolvente orgánico, y el índice de enfriado de dicha mezcla, se controlan con el fin de obtener una preparación de liposomas de tal manera que por lo menos aproximadamente 90% de los liposomas son de un tamaño de partícula menor de aproximadamente 200 nm.
MX2011006562A 2008-12-17 2009-12-17 Metodo para elaborar liposomas pequeños. MX2011006562A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13835308P 2008-12-17 2008-12-17
PCT/US2009/068499 WO2010078045A2 (en) 2008-12-17 2009-12-17 Method of making small liposomes

Publications (1)

Publication Number Publication Date
MX2011006562A true MX2011006562A (es) 2011-09-27

Family

ID=42310550

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2011006562A MX2011006562A (es) 2008-12-17 2009-12-17 Metodo para elaborar liposomas pequeños.

Country Status (12)

Country Link
US (3) US20120034294A1 (es)
EP (1) EP2367532A4 (es)
JP (2) JP2012512260A (es)
KR (1) KR101452033B1 (es)
CN (2) CN105935352A (es)
AU (1) AU2009333177B2 (es)
BR (1) BRPI0923001A2 (es)
CA (1) CA2747182C (es)
EA (1) EA020604B1 (es)
MX (1) MX2011006562A (es)
SG (1) SG172257A1 (es)
WO (1) WO2010078045A2 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI395591B (zh) * 2004-04-01 2013-05-11 Oncothyreon Inc 黏液性糖蛋白（ｍｕｃ-１）疫苗
JP5771366B2 (ja) * 2009-09-02 2015-08-26 株式会社バイオメッドコア リポソーム製造装置及び方法
MX2013009742A (es) 2011-02-24 2014-01-31 Oncothyreon Inc Vacuna de glicolipopeptidos a base de muc1 con adyuvante.
KR101387575B1 (ko) * 2012-08-10 2014-04-23 서울대학교산학협력단 인지질 및 아세틸렌기를 포함하는 리포좀 및 그의 용도
US9693958B2 (en) * 2013-03-15 2017-07-04 Cureport, Inc. Methods and devices for preparation of lipid nanoparticles
CA2977827C (en) * 2015-03-19 2023-10-17 University Of Connecticut Systems and methods for continuous manufacturing of liposomal drug formulations
JP6942376B2 (ja) * 2017-04-13 2021-09-29 国立大学法人北海道大学 流路構造体およびこれを用いた脂質粒子ないしミセル形成方法
JP2022525540A (ja) 2019-03-19 2022-05-17 アークトゥラス・セラピューティクス・インコーポレイテッド 脂質封入ｒｎａナノ粒子の製造方法
EP3711749A1 (en) * 2019-03-19 2020-09-23 Polymun Scientific Immunbiologische Forschung GmbH Method of making lipid nanoparticles
WO2023041588A1 (en) 2021-09-14 2023-03-23 Advapharm Gmbh Novel lipopeptide formulation

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11139961A (ja) * 1997-11-06 1999-05-25 Taisho Pharmaceut Co Ltd リポソームの製造方法
EP1045688A1 (en) * 1998-01-16 2000-10-25 Biomira Usa Inc. Lipomatrix preparation
CN1228041C (zh) * 1999-07-15 2005-11-23 英耐克斯药品股份有限公司 脂质包埋的治疗剂的制备方法
EP1232168B1 (en) * 1999-11-15 2011-08-03 Oncothyreon Inc. Synthetic lipid-a analogs and uses thereof
AU1999802A (en) * 2000-12-01 2002-06-11 Lawrence Boni Preparation of large liposomes by infusion into peg
US20030235610A1 (en) * 2002-06-21 2003-12-25 Piedmont Pharmaceuticals, Llc Liposomes containing biologically active compounds
WO2004071638A2 (en) * 2003-02-11 2004-08-26 Regents Of The University Of California, The Microfluidic devices and method for controlled viscous shearing and formation of amphiphilic vesicles
US9198645B2 (en) * 2003-11-26 2015-12-01 The United States of America, as represented by the Secretary of Commerce of The National Institute of Standards and Technology Controlled vesicle self-assembly in continuous two phase flow microfluidic channels
TWI395591B (zh) * 2004-04-01 2013-05-11 Oncothyreon Inc 黏液性糖蛋白（ｍｕｃ-１）疫苗
WO2006079216A1 (en) * 2005-01-28 2006-08-03 Bc Cancer Agency Liposomal compositions for parenteral delivery of agents
AU2006274651B2 (en) * 2005-06-28 2012-09-27 Oncothyreon Inc. Method of treating patients with a mucinous glycoprotein (MUC-1) vaccine
AU2006274413B2 (en) * 2005-07-27 2013-01-10 Arbutus Biopharma Corporation Systems and methods for manufacturing liposomes
JP5600432B2 (ja) * 2006-04-06 2014-10-01 インスメッド， インコーポレイテッド コアセルベート化誘導リポソーム被包法及びその調合物
US7811603B2 (en) * 2006-05-09 2010-10-12 The Regents Of The University Of California Microfluidic device for forming monodisperse lipoplexes
JP5126874B2 (ja) * 2007-05-21 2013-01-23 国立大学法人神戸大学 リポソーム製剤の製造方法

Also Published As

Publication number Publication date
CN102256595A (zh) 2011-11-23
SG172257A1 (en) 2011-07-28
JP2012512260A (ja) 2012-05-31
US20150315217A1 (en) 2015-11-05
AU2009333177A1 (en) 2011-07-07
EP2367532A4 (en) 2012-12-12
AU2009333177B2 (en) 2013-09-19
JP2014224127A (ja) 2014-12-04
BRPI0923001A2 (pt) 2018-09-18
US20120034294A1 (en) 2012-02-09
CA2747182A1 (en) 2010-07-08
JP5895030B2 (ja) 2016-03-30
EA020604B1 (ru) 2014-12-30
WO2010078045A2 (en) 2010-07-08
CN105935352A (zh) 2016-09-14
CA2747182C (en) 2014-11-18
US20130330398A1 (en) 2013-12-12
EP2367532A2 (en) 2011-09-28
WO2010078045A3 (en) 2010-10-28
KR20110094114A (ko) 2011-08-19
KR101452033B1 (ko) 2014-10-21
EA201100829A1 (ru) 2012-02-28

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