CN102186851B - Pim激酶抑制剂三唑并吡啶化合物 - Google Patents
Pim激酶抑制剂三唑并吡啶化合物 Download PDFInfo
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- CN102186851B CN102186851B CN2009801413028A CN200980141302A CN102186851B CN 102186851 B CN102186851 B CN 102186851B CN 2009801413028 A CN2009801413028 A CN 2009801413028A CN 200980141302 A CN200980141302 A CN 200980141302A CN 102186851 B CN102186851 B CN 102186851B
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- Prior art keywords
- pyridin
- quinoline
- triazolos
- fluorine
- oxygen base
- Prior art date
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| TWI417095B (zh) | 2006-03-15 | 2013-12-01 | Janssen Pharmaceuticals Inc | １，４-二取代之３-氰基-吡啶酮衍生物及其作為ｍＧｌｕＲ２-受體之正向異位性調節劑之用途 |
| TW200845978A (en) | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
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| WO2008157208A2 (en) | 2007-06-13 | 2008-12-24 | Incyte Corporation | Salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile |
| EP2203439B1 (en) | 2007-09-14 | 2011-01-26 | Ortho-McNeil-Janssen Pharmaceuticals, Inc. | 1',3'-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2h, 1'h-ý1, 4'¨bipyridinyl-2'-ones |
| CN101848893B (zh) | 2007-09-14 | 2012-06-06 | 奥梅-杨森制药有限公司 | 1,3-二取代的4-(芳基-x-苯基)-1h-吡啶-2-酮 |
| AU2008297877C1 (en) | 2007-09-14 | 2013-11-07 | Addex Pharma S.A. | 1,3-disubstituted-4-phenyl-1 H-pyridin-2-ones |
| CN101861316B (zh) | 2007-11-14 | 2013-08-21 | 奥梅-杨森制药有限公司 | 咪唑并[1,2-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途 |
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| JP5707390B2 (ja) | 2009-05-12 | 2015-04-30 | ジャンセン ファーマシューティカルズ， インコーポレイテッド | １，２，４−トリアゾロ［４，３−ａ］ピリジン誘導体およびｍＧｌｕＲ２受容体の正のアロステリック調節因子としてのその使用 |
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| DK2432472T3 (da) | 2009-05-22 | 2019-11-18 | Incyte Holdings Corp | 3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]octan- eller heptan-nitril som jak-inhibitorer |
| TW201113285A (en) | 2009-09-01 | 2011-04-16 | Incyte Corp | Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors |
| PH12015502575A1 (en) | 2010-03-10 | 2017-04-24 | Incyte Corp | Piperidin-4-yl azetidine derivatives as jak1 inhibitors |
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| CN102186851A (zh) | 2011-09-14 |
| PL2334677T3 (pl) | 2014-03-31 |
| SMT201400154B (it) | 2015-01-15 |
| US8575145B2 (en) | 2013-11-05 |
| RS53079B (sr) | 2014-06-30 |
| EP2334677B1 (en) | 2013-10-09 |
| DK2334677T3 (da) | 2013-11-18 |
| US20110144085A1 (en) | 2011-06-16 |
| HRP20131140T1 (hr) | 2014-01-03 |
| ES2439501T3 (es) | 2014-01-23 |
| UY32057A (es) | 2011-01-31 |
| SI2334677T1 (sl) | 2013-12-31 |
| EP2334677A1 (en) | 2011-06-22 |
| AR073079A1 (es) | 2010-10-13 |
| TWI496779B (zh) | 2015-08-21 |
| PT2334677E (pt) | 2013-11-26 |
| JP2014129409A (ja) | 2014-07-10 |
| CA2734831C (en) | 2017-04-18 |
| CA2734831A1 (en) | 2010-02-25 |
| TW201008940A (en) | 2010-03-01 |
| WO2010022076A1 (en) | 2010-02-25 |
| JP2012500277A (ja) | 2012-01-05 |
| JP5518072B2 (ja) | 2014-06-11 |
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