CN102124003A - 作为治疗呼吸系统疾病的β2肾上腺素受体拮抗剂的苯并噁嗪酮衍生物 - Google Patents
作为治疗呼吸系统疾病的β2肾上腺素受体拮抗剂的苯并噁嗪酮衍生物 Download PDFInfo
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- CN102124003A CN102124003A CN2009801320729A CN200980132072A CN102124003A CN 102124003 A CN102124003 A CN 102124003A CN 2009801320729 A CN2009801320729 A CN 2009801320729A CN 200980132072 A CN200980132072 A CN 200980132072A CN 102124003 A CN102124003 A CN 102124003A
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- Prior art keywords
- ethyl
- oxyethyl group
- propionic acid
- mixture
- benzene oxyethyl
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7342008P | 2008-06-18 | 2008-06-18 | |
| US61/073,420 | 2008-06-18 | ||
| PCT/SE2009/050749 WO2009154557A1 (en) | 2008-06-18 | 2009-06-17 | Benzoxazinone derivatives acting as beta2-adrenoreceptor agonist for the treatment of respiratory disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102124003A true CN102124003A (zh) | 2011-07-13 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CN2009801320729A Pending CN102124003A (zh) | 2008-06-18 | 2009-06-17 | 作为治疗呼吸系统疾病的β2肾上腺素受体拮抗剂的苯并噁嗪酮衍生物 |
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| Country | Link |
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| US (1) | US8017602B2 (https=) |
| EP (1) | EP2303873A4 (https=) |
| JP (1) | JP2011524896A (https=) |
| KR (1) | KR20110017456A (https=) |
| CN (1) | CN102124003A (https=) |
| AR (1) | AR072189A1 (https=) |
| AU (1) | AU2009260899B2 (https=) |
| BR (1) | BRPI0915428A2 (https=) |
| CA (1) | CA2726746A1 (https=) |
| CL (1) | CL2010001459A1 (https=) |
| CO (1) | CO6321269A2 (https=) |
| CR (1) | CR11856A (https=) |
| DO (1) | DOP2010000389A (https=) |
| EA (1) | EA201001747A1 (https=) |
| EC (1) | ECSP10010694A (https=) |
| IL (1) | IL209731A0 (https=) |
| MX (1) | MX2010013477A (https=) |
| TW (1) | TW201002696A (https=) |
| UY (1) | UY31905A (https=) |
| WO (1) | WO2009154557A1 (https=) |
| ZA (1) | ZA201008886B (https=) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102993116A (zh) * | 2012-12-04 | 2013-03-27 | 常州大学 | 一种苯并噁嗪类激动剂的制备方法 |
| CN104496920A (zh) * | 2014-12-04 | 2015-04-08 | 北京理工大学 | 一种n-烯丙基-二取代四唑及其制备方法和检测方法 |
| CN106536491A (zh) * | 2014-06-30 | 2017-03-22 | 阿斯利康(瑞典)有限公司 | 作为盐皮质激素受体调节剂的苯并噁嗪酮酰胺 |
| CN107188865A (zh) * | 2016-03-14 | 2017-09-22 | 益方生物科技（上海）有限公司 | 苯并噁嗪化合物及其制备方法和用途 |
| CN117143019A (zh) * | 2023-07-28 | 2023-12-01 | 常州大学 | 用作β2-肾上腺素受体别构拮抗剂的吡唑酰胺类衍生物 |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009154557A1 (en) | 2008-06-18 | 2009-12-23 | Astrazeneca Ab | Benzoxazinone derivatives acting as beta2-adrenoreceptor agonist for the treatment of respiratory disorders |
| WO2011048409A1 (en) | 2009-10-20 | 2011-04-28 | Astrazeneca Ab | Cyclic amine derivatives having beta2 adrenergic receptor agonist and muscarinic receptor antagonist activity |
| WO2011073662A1 (en) | 2009-12-17 | 2011-06-23 | Astrazeneca Ab | Combination of a benzoxazinone and a further agent for treating respiratory diseases |
| PL424609A1 (pl) * | 2018-02-16 | 2019-08-26 | Uniwersytet Przyrodniczy we Wrocławiu | Zastosowanie 6-(tert-butylo)-3-dodecylo-3,4-dihydro-2H-benzo[e][1,3]oxazyny |
| CN110028521B (zh) * | 2019-05-27 | 2020-07-14 | 湖南科技大学 | 11-芳基-1,4-苯并恶嗪酮并咪唑啉类化合物及其制备方法和用途 |
| EP4194453A1 (en) | 2021-12-08 | 2023-06-14 | Basf Se | Pyrazine compounds for the control of invertebrate pests |
| WO2023104564A1 (en) | 2021-12-08 | 2023-06-15 | Basf Se | Pyrazine compounds for the control of invertebrate pests |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007027133A1 (en) * | 2005-08-29 | 2007-03-08 | Astrazeneca Ab | 7-(2-AMINO-1-HYDROXY-ETHYL)-4-HYDROXYBENZOTHIAZOL-2(3H)-ONE-DERIVATIVES AS β2 ADRENOCEPTOR AGONISTS |
| WO2007102771A1 (en) * | 2006-03-08 | 2007-09-13 | Astrazeneca Ab | Phenethanolamine derivatives as beta2 adrenoreceptor agonists |
| WO2008075025A1 (en) * | 2006-12-20 | 2008-06-26 | Astrazeneca Ab | Amine derivatives and their use in beta-2-adrenoreceptor mediated diseases |
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| US2653977A (en) | 1953-09-29 | Chxnx | ||
| US3775477A (en) | 1971-03-10 | 1973-11-27 | Sterling Drug Inc | N,n'-bis(2-aryl-2-(hydroxy or oxo)-ethyl)-bridged-bis-carboxamides |
| US4460581A (en) | 1982-10-12 | 1984-07-17 | Boehringer Ingelheim Kg | (1-Hydroxy-2-amino-alkyl)-substituted benzoxazinones and benzoxazolinones |
| EP0162576B1 (en) | 1984-04-17 | 1989-07-26 | Glaxo Group Limited | Ethanolamine compounds |
| US4554284A (en) | 1984-09-12 | 1985-11-19 | Smithkline Beckman Corporation | 7-(2-Aminoethyl)-1,3-benzthia- or oxa-zol-2(3H)-ones |
| US4554287A (en) | 1984-09-12 | 1985-11-19 | Smithkline Beckman Corporation | Antihypertensive 7-[2-(dialkylamino)ethyl]-4-hydroxy-1,3-benzimidazol-2-ones |
| GB8525483D0 (en) | 1985-10-16 | 1985-11-20 | Glaxo Group Ltd | Chemical compounds |
| GB8718938D0 (en) | 1987-08-11 | 1987-09-16 | Glaxo Group Ltd | Chemical compounds |
| NZ235605A (en) | 1989-10-10 | 1992-12-23 | Glaxo Group Ltd | (r)-(-)-4-hydroxy-alpha 1 -(((6-(4-phenylbutoxy)hexyl)amino)methyl)-1,3-benzenedimethanol and pharmaceutical compositions |
| US5648370A (en) | 1990-11-20 | 1997-07-15 | Astra Pharmaceuticals Limited | 7-(2-aminoethyl) benzothiazolones |
| GB9211172D0 (en) | 1992-05-27 | 1992-07-08 | Fisons Plc | Compounds |
| GB9210632D0 (en) | 1992-05-19 | 1992-07-01 | Fisons Plc | Compounds |
| IE914003A1 (en) | 1990-11-20 | 1992-05-20 | Astra Pharma Prod | Biologically Active Amines |
| TW356468B (en) | 1995-09-15 | 1999-04-21 | Astra Pharma Prod | Benzothiazolone compounds useful as beta2-adrenoreceptor and dopamine DA2 receptor agonists process for preparing same and pharmaceutical compositions containing same |
| GB9526511D0 (en) | 1995-12-23 | 1996-02-28 | Astra Pharma Prod | Pharmaceutically active compounds |
| DE69709647T2 (de) | 1996-05-20 | 2002-11-07 | Dupont Pharmaceuticals Research Laboratories, Inc. | Cyclischer diarylalkyl diaminederivate als antogoniste von chemokinerezeptoren |
| SE9700706D0 (sv) | 1997-02-27 | 1997-02-27 | Astra Pharma Prod | Process for the preparation of benzothiazoline compounds |
| SE9701304D0 (sv) | 1997-04-09 | 1997-04-09 | Astra Pharma Prod | Compounds |
| JP2002509119A (ja) | 1998-01-13 | 2002-03-26 | アストラゼネカ ユーケイ リミテッド | ドーパミン（Ｄ２）レセプターアゴニスト活性を有する化合物およびβ２−アドレナリンレセプターアゴニスト活性を有する化合物（Ｂ）を含有する薬学的組成物 |
| US6541669B1 (en) | 1998-06-08 | 2003-04-01 | Theravance, Inc. | β2-adrenergic receptor agonists |
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| US6683115B2 (en) | 1999-06-02 | 2004-01-27 | Theravance, Inc. | β2-adrenergic receptor agonists |
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- 2009-06-17 CN CN2009801320729A patent/CN102124003A/zh active Pending
- 2009-06-17 KR KR1020117001144A patent/KR20110017456A/ko not_active Withdrawn
- 2009-06-17 TW TW098120291A patent/TW201002696A/zh unknown
- 2009-06-17 BR BRPI0915428A patent/BRPI0915428A2/pt not_active IP Right Cessation
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- 2009-06-17 CA CA2726746A patent/CA2726746A1/en not_active Abandoned
- 2009-06-18 US US12/486,854 patent/US8017602B2/en not_active Expired - Fee Related
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102993116A (zh) * | 2012-12-04 | 2013-03-27 | 常州大学 | 一种苯并噁嗪类激动剂的制备方法 |
| CN106536491A (zh) * | 2014-06-30 | 2017-03-22 | 阿斯利康(瑞典)有限公司 | 作为盐皮质激素受体调节剂的苯并噁嗪酮酰胺 |
| CN106536491B (zh) * | 2014-06-30 | 2018-12-18 | 阿斯利康(瑞典)有限公司 | 作为盐皮质激素受体调节剂的苯并噁嗪酮酰胺 |
| CN104496920A (zh) * | 2014-12-04 | 2015-04-08 | 北京理工大学 | 一种n-烯丙基-二取代四唑及其制备方法和检测方法 |
| CN107188865A (zh) * | 2016-03-14 | 2017-09-22 | 益方生物科技（上海）有限公司 | 苯并噁嗪化合物及其制备方法和用途 |
| CN117143019A (zh) * | 2023-07-28 | 2023-12-01 | 常州大学 | 用作β2-肾上腺素受体别构拮抗剂的吡唑酰胺类衍生物 |
Also Published As
| Publication number | Publication date |
|---|---|
| ECSP10010694A (es) | 2011-01-31 |
| CO6321269A2 (es) | 2011-09-20 |
| BRPI0915428A2 (pt) | 2015-11-03 |
| JP2011524896A (ja) | 2011-09-08 |
| CR11856A (es) | 2011-02-25 |
| AU2009260899A1 (en) | 2009-12-23 |
| US8017602B2 (en) | 2011-09-13 |
| MX2010013477A (es) | 2010-12-21 |
| ZA201008886B (en) | 2011-08-31 |
| EA201001747A1 (ru) | 2011-08-30 |
| TW201002696A (en) | 2010-01-16 |
| AR072189A1 (es) | 2010-08-11 |
| IL209731A0 (en) | 2011-02-28 |
| EP2303873A4 (en) | 2012-01-04 |
| US20100105642A1 (en) | 2010-04-29 |
| KR20110017456A (ko) | 2011-02-21 |
| CA2726746A1 (en) | 2009-12-23 |
| DOP2010000389A (es) | 2011-01-15 |
| UY31905A (es) | 2010-01-29 |
| CL2010001459A1 (es) | 2011-09-23 |
| EP2303873A1 (en) | 2011-04-06 |
| AU2009260899B2 (en) | 2012-02-23 |
| WO2009154557A1 (en) | 2009-12-23 |
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