CN101983242B - 含有尿素类氮源的发酵培养基及其用于生产重组蛋白的用途 - Google Patents

含有尿素类氮源的发酵培养基及其用于生产重组蛋白的用途 Download PDF

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CN101983242B
CN101983242B CN200980112059.7A CN200980112059A CN101983242B CN 101983242 B CN101983242 B CN 101983242B CN 200980112059 A CN200980112059 A CN 200980112059A CN 101983242 B CN101983242 B CN 101983242B
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urea
fermentation
fermentation medium
insulin
medium
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CN101983242A (zh
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桑贾伊·蒂瓦里
穆克什·巴布阿帕·帕塔勒
沙鲁巴·加格
马扬克·库马·加格
苏勒克哈·约希
奇特纳利·拉梅高达·那文·库马
比马尔·库马
安努杰·格尔
哈里什·耶尔
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Biocon Ltd
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    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/38—Chemical stimulation of growth or activity by addition of chemical compounds which are not essential growth factors; Stimulation of growth by removal of a chemical compound
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C12N9/20—Triglyceride splitting, e.g. by means of lipase
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
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    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

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CN200980112059.7A 2008-02-06 2009-02-05 含有尿素类氮源的发酵培养基及其用于生产重组蛋白的用途 Active CN101983242B (zh)

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CN201310522914.XA CN103642843B (zh) 2008-02-06 2009-02-05 含有尿素类氮源的发酵培养基及其用于生产次级代谢产物、酶和重组蛋白的用途

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IN310CH2008 2008-02-06
IN00310/CHE/2008 2008-02-06
IN00086/CHE/2009 2009-01-12
IN86CH2009 2009-01-12
PCT/IN2009/000078 WO2009113099A2 (en) 2008-02-06 2009-02-05 Fermentation medias and processes thereof

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US (2) US8927256B2 (https=)
EP (2) EP2247737B1 (https=)
JP (1) JP5587795B2 (https=)
KR (2) KR101492011B1 (https=)
CN (2) CN101983242B (https=)
BR (1) BRPI0905853B1 (https=)
IL (2) IL207402A (https=)
MX (2) MX2010008654A (https=)
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CN101983242B (zh) * 2008-02-06 2015-12-16 拜康有限公司 含有尿素类氮源的发酵培养基及其用于生产重组蛋白的用途
UA116217C2 (uk) 2012-10-09 2018-02-26 Санофі Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону
HK1211232A1 (en) 2012-12-21 2016-05-20 Sanofi Exendin-4 derivatives as dual glp1/gip or trigonal glp1/gip/glucagon agonists
CN103911298B (zh) * 2012-12-31 2016-08-10 中粮营养健康研究院有限公司 培养基组合物和培养基及对菌株进行活菌计数的方法
WO2015086728A1 (en) 2013-12-13 2015-06-18 Sanofi Exendin-4 peptide analogues as dual glp-1/gip receptor agonists
WO2015086733A1 (en) 2013-12-13 2015-06-18 Sanofi Dual glp-1/glucagon receptor agonists
TW201609799A (zh) 2013-12-13 2016-03-16 賽諾菲公司 雙重ｇｌｐ－１／ｇｉｐ受體促效劑
EP3080152A1 (en) 2013-12-13 2016-10-19 Sanofi Non-acylated exendin-4 peptide analogues
TW201625668A (zh) 2014-04-07 2016-07-16 賽諾菲公司 作為胜肽性雙重ｇｌｐ－１／昇糖素受體激動劑之艾塞那肽－４衍生物
TW201625670A (zh) 2014-04-07 2016-07-16 賽諾菲公司 衍生自ｅｘｅｎｄｉｎ－４之雙重ｇｌｐ－１／升糖素受體促效劑
TW201625669A (zh) 2014-04-07 2016-07-16 賽諾菲公司 衍生自艾塞那肽－４（Ｅｘｅｎｄｉｎ－４）之肽類雙重ＧＬＰ－１／升糖素受體促效劑
US9932381B2 (en) 2014-06-18 2018-04-03 Sanofi Exendin-4 derivatives as selective glucagon receptor agonists
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AR105284A1 (es) 2015-07-10 2017-09-20 Sanofi Sa Derivados de exendina-4 como agonistas peptídicos duales específicos de los receptores de glp-1 / glucagón
CN108350471A (zh) * 2015-10-20 2018-07-31 巴克曼实验室国际公司 增强用于发酵生物产品生产的酵母生长的方法及其营养组合物
KR20180103961A (ko) * 2016-01-23 2018-09-19 바이오콘 리미티드 인슐린 유사체에 대한 생물학적 분석 방법
CN107022591B (zh) * 2017-05-11 2018-06-12 宜昌东阳光长江药业股份有限公司 一种提高胰岛素及其类似物前体表达的毕赤酵母发酵方法
WO2018216978A1 (en) * 2017-05-22 2018-11-29 Cj Healthcare Corporation Cell culture method at low temperature applicable to mass production of protein
CN107988292B (zh) * 2018-01-18 2023-12-26 江苏江山聚源生物技术有限公司 提高重组人源胶原蛋白稳定性的发酵工艺
CN111411049B (zh) * 2020-04-15 2022-11-22 北京惠之衡生物科技有限公司 一种提高胰岛素前体表达的毕赤酵母的发酵培养基及发酵方法
CN111996136A (zh) * 2020-07-24 2020-11-27 北大方正集团有限公司 一种荧光假单孢杆菌发酵培养基、培养方法与应用
CN114507609B (zh) * 2020-12-22 2023-04-18 益海嘉里(连云港)生物科技有限公司 一种提高磷脂酶c蛋白产量的方法

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EP2565272A3 (en) 2013-07-03
JP5587795B2 (ja) 2014-09-10
US20100317056A1 (en) 2010-12-16
IL207402A0 (en) 2010-12-30
US9255285B2 (en) 2016-02-09
IL221379A0 (en) 2012-10-31
KR20100118592A (ko) 2010-11-05
KR101283734B1 (ko) 2013-07-08
RU2491345C2 (ru) 2013-08-27
JP2011510677A (ja) 2011-04-07
BRPI0905853A2 (pt) 2015-06-30
MY161108A (en) 2017-04-14
IL207402A (en) 2013-07-31
CN103642843B (zh) 2017-03-01
MX349413B (es) 2017-07-19
RU2012145969A (ru) 2014-05-10
EP2247737B1 (en) 2018-06-20
EP2565272A2 (en) 2013-03-06
SG188126A1 (en) 2013-03-28
US8927256B2 (en) 2015-01-06
CN101983242A (zh) 2011-03-02
RU2010137009A (ru) 2012-03-20
RU2556120C2 (ru) 2015-07-10
MX2010008654A (es) 2010-10-06
RU2011153811A (ru) 2013-07-10
BRPI0905853A8 (pt) 2019-01-29
US20140141467A1 (en) 2014-05-22
CN103642843A (zh) 2014-03-19
RU2595380C2 (ru) 2016-08-27
BRPI0905853B1 (pt) 2019-03-26
WO2009113099A2 (en) 2009-09-17
KR101492011B1 (ko) 2015-02-10
WO2009113099A3 (en) 2009-11-05
IL221379A (en) 2013-08-29
KR20120066068A (ko) 2012-06-21
EP2247737A2 (en) 2010-11-10
EP2247737A4 (en) 2012-03-14

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