CN101784273B - (2s，3r)‑n‑(2‑((3‑吡啶基)甲基)‑1‑氮杂双环[2.2.2]辛‑3‑基)苯并呋喃‑2‑甲酰胺、其新的盐形式和用法 - Google Patents

(2s，3r)‑n‑(2‑((3‑吡啶基)甲基)‑1‑氮杂双环[2.2.2]辛‑3‑基)苯并呋喃‑2‑甲酰胺、其新的盐形式和用法 Download PDF

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Publication number
CN101784273B
CN101784273B CN200880103971.1A CN200880103971A CN101784273B CN 101784273 B CN101784273 B CN 101784273B CN 200880103971 A CN200880103971 A CN 200880103971A CN 101784273 B CN101784273 B CN 101784273B
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Prior art keywords
azabicyclo
pyridyl
methyl
benzofuran
oct
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Expired - Fee Related
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CN200880103971.1A
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Chinese (zh)
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CN101784273A (zh
Inventor
M·本切里夫
L·本森
G·M·达尔
N·费德洛夫
G·J·加托
J·金奈斯
K·G·乔丹
J·马休
A·A·马祖罗夫
苗蓝
J·A·穆诺茨
I·费弗
S·费弗
T·Y·菲力普斯
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Gyre Therapeutics Inc
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Targacept Inc
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Application filed by Targacept Inc filed Critical Targacept Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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CN200880103971.1A 2007-08-02 2008-08-01 (2s，3r)‑n‑(2‑((3‑吡啶基)甲基)‑1‑氮杂双环[2.2.2]辛‑3‑基)苯并呋喃‑2‑甲酰胺、其新的盐形式和用法 Expired - Fee Related CN101784273B (zh)

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US95361307P 2007-08-02 2007-08-02
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US60/953,610 2007-08-02
US60/953,613 2007-08-02
US97165407P 2007-09-12 2007-09-12
US60/971,654 2007-09-12
PCT/US2008/071872 WO2009018505A1 (en) 2007-08-02 2008-08-01 (2s,3r)-n-(2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)benzofuran-2-carboxamide, novel salt forms, and methods of use thereof

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CN201611140124.5A Division CN106831755A (zh) 2007-08-02 2008-08-01 甲酰胺化合物及其盐形式和用途

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CN200880103971.1A Expired - Fee Related CN101784273B (zh) 2007-08-02 2008-08-01 (2s，3r)‑n‑(2‑((3‑吡啶基)甲基)‑1‑氮杂双环[2.2.2]辛‑3‑基)苯并呋喃‑2‑甲酰胺、其新的盐形式和用法
CN2013100489009A Pending CN103172628A (zh) 2007-08-02 2008-08-01 (2s,3r)-n-(2-((3-吡啶基)甲基)-1-氮杂双环[2.2.2]辛-3-基)苯并呋喃-2-甲酰胺、其新的盐形式和用法
CN201611140124.5A Pending CN106831755A (zh) 2007-08-02 2008-08-01 甲酰胺化合物及其盐形式和用途
CN200880101593A Pending CN101868237A (zh) 2007-08-02 2008-08-01 用于治疗或预防代谢紊乱的α7nAChR激动剂

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CN2013100489009A Pending CN103172628A (zh) 2007-08-02 2008-08-01 (2s,3r)-n-(2-((3-吡啶基)甲基)-1-氮杂双环[2.2.2]辛-3-基)苯并呋喃-2-甲酰胺、其新的盐形式和用法
CN201611140124.5A Pending CN106831755A (zh) 2007-08-02 2008-08-01 甲酰胺化合物及其盐形式和用途
CN200880101593A Pending CN101868237A (zh) 2007-08-02 2008-08-01 用于治疗或预防代谢紊乱的α7nAChR激动剂

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