CN101690706A - Chinese medicinal toothpaste and preparation method thereof - Google Patents
Chinese medicinal toothpaste and preparation method thereof Download PDFInfo
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- CN101690706A CN101690706A CN200910171933A CN200910171933A CN101690706A CN 101690706 A CN101690706 A CN 101690706A CN 200910171933 A CN200910171933 A CN 200910171933A CN 200910171933 A CN200910171933 A CN 200910171933A CN 101690706 A CN101690706 A CN 101690706A
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- toothpaste
- chinese medicinal
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- medicinal toothpaste
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Abstract
The invention relates to the field of toothpaste and provides Chinese medicinal toothpaste. The Chinese medicinal toothpaste comprises the following components in percentage by weight: 0.5 to 15.0 percent of beta-cyclodextrin inclusion rabdosia rubescens powder, 0.1 to 5.0 percent of binding agent, 8.0 to 45.0 percent of humectant, 0.1 to 3.0 percent of foaming agent, 5.0 to 35.0 percent of silicon dioxide, and 10.0 to 50.0 percent of calcium carbonate. The invention also provides a method for preparing the Chinese medicinal toothpaste. The Chinese medicinal toothpaste not only has a whitening function to effectively inhibit the formation of bacterial plaques, but also has the effects of reliving pain and stopping bleeding, can improve the symptoms of chronic pharyngitis, periodontal abscess and pericoronitis, has no stimulation to skin, and has a health care effect and a wide application prospect.
Description
Technical field
The present invention relates to the toothpaste technical field, be specifically related to a kind of Chinese medicinal toothpaste and preparation method thereof.
Background technology
Rabdosia rubescens belongs to perennial herb or undershrub for Labiatae scented tea, its bitter in the mouth, cold nature, its main inclusions is rubescensine A, second element, third element and fourth element, also contain volatile oil, alkaloid, bitter principle, lactone and flavone etc., have the effect of heat-clearing and toxic substances removing, anti-inflammatory analgetic and antitumor, be widely used in pharmaceutically.
The a large amount of evaluation of Rabdosia rubescens working substance structure, extraction process, the clinical application research that carry out early stage show, the Rabdosia rubescens working substance has antibiotic and antitumaous effect, referring to (Medical Science Inst., Henan Prov.'s pharmacology medicine group etc., the chemistry of rubescensin and pharmacological research [J]. Chinese herbal medicine communication .1977 (10): 5～7; Opening Tan washes one's hair. Chen Zhengyu. and rolling Jinhua etc. another antitumor effective ingredient-rubescensine B [J] in the Rabdosia rubescens. Science Bulletin, 1980 (22): 1051～1054.Sun HD, Chao JH, Lin ZW, et al.TheStructrue of Rubescensin C:A New Minor Diterpenoid isolated fromRabdosia rubescens[J] .Chen Pharm, Bull.1982.30 (1): 341～343).
Rabdosia rubescens not only has antitumor action, and studies have shown that further it can remove oxygen-derived free radicals (O
2-) and hydroxyl radical free radical (.OH), prompting has antioxidation, referring to (Dong Sun Han, the scientific research progress of Rabdosia rubescens, Chinese Chinese medicine newspaper, 2007.5.23).
The main effective ingredient of winter Rabdosia rubescens comprises: rubescensine A, rubescensine B, ursolic acid, oleanolic acid, rosmarinic acid etc., and details are as follows for their effect:
Rubescensine A (Rubescensine A), the about 0.6%-1.0% of content, function heat-clearing and toxic substances removing, promoting blood circulation and stopping pain.Cure mainly laryngopharynx swelling and pain, tonsillitis, flu, headache, tracheitis, chronic hepatitis, joint rheumatalgia, snake bite and insect sting.Multiple cancerous cell had the very strong inhibitory action of killing." Chinese pharmacopoeia, Rabdosia rubescens (Oridonin) has another name called rubescensine A, is kaurene skeleton tetracyclic diterpene compounds to take in version in 1977.
Rubescensine B (Rubescensine B), about 0.15%-0.19% has the very strong inhibitory action of killing to multiple cancerous cell, and has antibacterial action, and its structure is mapping-kaurene (ent-Kurene).
Ursolic acid (Ursolic Acid), about 0.414%-0.573%, having various biological effects such as calmness, antiinflammatory, antibiotic, anti-diabetic, antiulcer, blood sugar lowering, also have tangible anti-oxidation function, is a kind of nonpolar pentacyclic triterpenoid that is present in the natural plants
Oleanolic acid (Oleanic acid), about 0.45%-0.65% is pentacyclic triterpenoid, is present in the various plants with the form of episome and glycocide.Having hepatoprotective and fall enzyme, promote effects such as liver cell regeneration, antiinflammatory, heart tonifying, diuresis, antitumor also have blood sugar lowering, blood fat reducing, abirritative effect, is effective ingredients such as exploitation treatment hepatopathy and blood sugar lowering.
Rosmarinic acid (Rosmarinic acid), 0.5%-0.89% is present in a kind of polyphenol in many plants.Have effects such as antiinflammatory, antithrombotic, antitumor, solution fibrin, antioxidation, rosmarinic acid also has very strong non-oxidizability, and its anti-oxidant vigor is better than vitamin E, can reduce cancer and arteriosclerotic risk.
Teeth stains is common in the crowd, influences attractive in appearance.Wherein, exogenous mottle mainly is owing to drink the beverage that contains pigment, ediblely have the food of pigment and smoking to cause.Remove exogenous mottle and be meant the mottle of removing acquired film of facing and enamel top layer, generally be to whiten by physics, it mainly is mottle generation physical property friction by the abrasivus that includes and dental surface, removal is positioned at the mottle on enamel top layer, shortcoming is to have added oxidant, the effect that generally brightens is very little, and is very big to the damage of tooth.
Removing the endogenous mottle then needs to advance with porous the medicine of facing organizational structure, be that chemistry is whitened, to contain chemical substance such as hydrogen peroxide or peroxidating carbon diamidogen and play discoloration, when it decomposes the generation free radical because of redox effect, organic pigment can be bleached to colourless disposition structure by the carbocyclic ring structure, make two keys of pigment molecular convert singly-bound to and strip color, and reach the dental bleaching effect.This whitening toothpaste is the damage tooth structure very easily, also can allow tooth become fragile in the course of time and can't bear.
Summary of the invention
The deficiency big to injury of teeth that the present invention is directed to that prior art toothpaste is poor by the physical beauty white effect, chemistry is whitened proposes a kind of getting and can effectively remove bacterial plaque, the little Chinese medicinal toothpaste of side effect.
In order to realize the foregoing invention purpose, the invention provides following technical scheme:
A kind of Chinese medicinal toothpaste, its component is by weight percentage:
Beta-cyclodextrin inclusion compound Rabdosia rubescens powder 0.5%-15.0%
Binding agent 0.1%-5.0%
Wetting agent 8.0%-45.0%
Foaming agent 0.1%-3.0%
Silicon dioxide 5.0%-35.0%
Calcium carbonate 10.0%-50.0%.
Preferably, described binding agent is nanometer rheology thickening agent, more preferably nanometer grade silica or Nano titanium dioxide.As patent anatase-type nanometer titanium dioxide (Chinese patent ZL200410019084.X; Chinese patent CN101121834).Adopt the nano thickening agent can set up lotion of toothpaste thixotroping and associating network structure, under the very big situation of the temperature difference mastic do not emanate, do not swim, the viscosity no change, and owing to the existence of nano material also has certain bacteriostasis.
Preferably, described wetting agent is a sorbitol, accord with Q B/T 2335-97 standard.
Foaming agent
One of The Fourth Military Medical University studies show that, and is commonly used in the toothpaste, can produce foamy de-sludging composition sodium lauryl sulphate (SDS) health is had potential hazard.Studies show that SDS concentration can influence the periodontal ligament cell growth less than 0.0025%; Concentration reaches at 0.01% o'clock, and cytoactive can obviously reduce; Concentration is greater than 0.01%, and cell can be all dead.And the SDS content in the domestic toothpaste is generally 0.3%-0.5%, head and shoulders above safety value.The present invention adopts natural purified Herba Cassiae Nomamis peel extract or tea saponin as foaming agent, Herba Cassiae Nomamis contains natural lipase and the multiple aldehydes matter of pressing down, can go in the blood circulation by fat molecule being stranded in do not digested and absorb in the intestines and stomach pipeline, the absorption of fat be had concurrently treatment bronchitis and all kinds of edema, preventing phlegm from forming and stopping coughing effect again thereby reduce human body; Tea saponin has antibacterial action, and Candida albicans, escherichia coli are all had inhibitory action, can treat dermatosis.
Abrasivus
The abrasivus kind is many.Wherein, use phosphate as abrasivus, phosphatic discharging is quite serious to the pollution of water resource; Use aluminium oxide as abrasivus, residual enrichment aluminium compound is unfavorable to person health.We are according to the differentiated friction value of several abrasivuss such as calcium carbonate, calcium hydrogen phosphate, aluminium hydroxide, silicon dioxide, calcium pyrophosphate, sodium monofluorophosphate etc., choose that calcium carbonate and silicon dioxide are composite to form.Silicon dioxide is toothpaste level QB/T 2346-1997, and calcium carbonate content is 10.0%-50.0%, meets toothpaste level QB/T 2317-1997 standard, effectively avoids the residual of environmental pollution and aluminum.
Chinese medicinal toothpaste of the present invention preferably also comprises emulsifying agent, coloring agent, sweeting agent, flavouring agent or antiseptic.
Emulsifying agent
Described emulsifying agent is preferably the lecithin that accounts for toothpaste weight 0.1%-5.0%.Lecithin be a kind of be one of lipid component of needing of human body.Replenish lecithin to human body, can repair the cell membrane that is damaged, improve cell membrane function, make the softening and rejuvenation of cell membrane, increase cytoactive.Lecithin is widely used in food as a kind of natural green lipoid substance, health product, and fields such as cosmetics are called as " edible cosmetics ".Be applied to then have the protection gingiva in the toothpaste, prevent the function of periodontal blooding.Adopt pure natural lecithin as emulsifying agent in the toothpaste, can make the sufficient emulsifying of derived essential oil and then improve the lotion of toothpaste form and increase its stability with thickener rheology agent is collaborative.
Coloring agent
Described coloring agent is preferably the titanium dioxide that accounts for toothpaste weight 0.5%-5.0%.Titanium dioxide is one of safest chemical compound in the whole periodic chart, is avirulence by U.S. FDA authentication, has been used for the sunscreen cream, toothpaste, medication for oral administration of food additive such as chocolate, cosmetics etc.Its adhesive force and covering power are very big, add the whiteness that can increase mastic in the mastic, also can be used as a kind of adjuvant of abrasivus.Content of titanium dioxide is 0.5%-5.0%, is the food additive/painted covering agent of sheltering that meets the GB2760-1996 standard.
Sweeting agent
Described sweeting agent is preferably the xylitol that accounts for toothpaste weight 0.1%-10.0%.Streptococcus mutans that exists in the oral cavity and lactobacillus are the main bacteria that causes dental caries.Xylitol can suppress to cause the bacteria breed of dental caries growth, thereby reaches good anti-dental caries effect.The external verified Xylitol chewing gum of chewing of many researchs has inhibitory action to Streptococcus mutans and lactobacillus, because its sugariness is suitable with sucrose, can replace the sweeting agent of synthetic simultaneously.
Flavouring agent
Described flavouring agent is the natural Fructus Citri tangerinae quintessence oil that accounts for toothpaste weight 0.1%-1.0%, natural Herba Menthae quintessence oil or natural spearmint essential oil.Natural menthence (or Herba Menthae Rotundifoliae, natural orange peel extract quintessence oil) as the flavouring agent composition, has refrigerant skin smoothing, refreshment simultaneously, dispel the wind be good for the stomach, suppress nerve, with all worries set aside, the cough-relieving desensitization of calming the nerves, fragrance wet one's whistle wind dispelling, antiseptical effect.
Described antiseptic is preferably and accounts for toothpaste weight 0.1%-1.0% potassium sorbate.The preferred potassium sorbate that adopts food safety is for meeting the food additive of GB13736-2008 standard.
The present invention also provides the preparation method of described Chinese medicinal toothpaste, comprises following steps:
Step 1: Rabdosia rubescens is ground into the 30-60 order, adds the ethanol of 55%-95%, at 50-75 ℃ of backflow 3-5 hour, it was standby to fetch flow liquid;
Step 2: behind backflow distilling under reduced pressure recovery ethanol, add saturated beta-schardinger dextrin-and reflux, obtain buff powder through vacuum drying, pulverizing again, be beta-cyclodextrin inclusion compound Rabdosia rubescens powder;
Step 3: beta-cyclodextrin inclusion compound Rabdosia rubescens powder and other components are mixed and be uniformly dispersed;
Step 4: said mixture outgased to stir under vacuum promptly gets Chinese medicinal toothpaste of the present invention.
Wherein, the described backflow of step 2 was preferably at 25 ℃ of-75 ℃ of following backflow 1-10 hours.
Chinese medicinal toothpaste of the present invention does not add harmful chemosynthesis material, avoids phosphorus-containing compound, aluminum oxide to environment and human body harmful, chooses natural toothpaste level calcium carbonate and silicon dioxide, does not pollute the environment.The not only Pear Power effect of described Chinese medicinal toothpaste effectively suppresses the formation of bacterial plaque, and has the analgesic hemostatic effect, can improve chronic pharyngolaryngitis, periodontal abscess all inflammation shapes of coming of age, to skin thing zest, be a kind of Chinese medicinal toothpaste with health role, be with a wide range of applications.
The specific embodiment
Embodiment 1:
A kind of Chinese medicinal toothpaste, various raw material components proportionings are expressed as follows with percentage by weight:
Beta-cyclodextrin inclusion compound Rabdosia rubescens powder 0.5%,
Binding agent: nanometer grade silica 5%,
Wetting agent: sorbitol 45.0%,
Foaming agent: Fructus Gleditsia peel extract 0.1%,
Abrasivus: silicon dioxide 35%, calcium carbonate 10%,
Water surplus.
Embodiment 2:
Beta-cyclodextrin inclusion compound Rabdosia rubescens powder 5.5%,
Binding agent: nanometer rheology thickening agent titanium dioxide 0.1%,
Wetting agent: sorbitol 25%,
Foaming agent: tea saponin 3%,
Abrasivus: silicon dioxide 8%, calcium carbonate 50%,
Water surplus.
Embodiment 3:
Beta-cyclodextrin inclusion compound Rabdosia rubescens powder 15%,
Binding agent: nanometer rheology thickening agent titanium dioxide 1%,
Wetting agent: sorbitol 8.0%,
Foaming agent: Fructus Gleditsia peel extract 1.5%, tea saponin 1%,
Abrasivus: silicon dioxide 5%, calcium carbonate 40%,
Water surplus.
Embodiment 4:
A kind of Chinese medicinal toothpaste, various raw material components proportionings are expressed as with percentage by weight:
Beta-cyclodextrin inclusion compound Rabdosia rubescens powder 1.0%,
Binding agent: nanometer rheology thickener-silica 0.6%,
Emulsifying agent: lecithin 2.0%,
Flavouring agent: natural Herba Menthae quintessence oil 1.0%,
Sweeting agent: xylitol 6.0%,
Wetting agent: sorbitol 40.0%,
Foaming agent: tea saponin 0.5%,
Abrasivus: silicon dioxide 7%, calcium carbonate 23%,
Coloring agent: titanium dioxide 5.0%,
Antiseptic: potassium sorbate 0.3%, water surplus.
Embodiment 5:
A kind of Chinese medicinal toothpaste, various raw material components proportionings are expressed as follows with percentage by weight:
Beta-cyclodextrin inclusion compound Rabdosia rubescens powder 0.5%,
Binding agent: nanometer rheology thickening agent titanium dioxide 0.1%,
Emulsifying agent: lecithin 0.1%,
Flavouring agent: spearmint essential oil 0.1%,
Sweeting agent: xylitol 0.1%,
Wetting agent: sorbitol 8.0%,
Foaming agent: Fructus Gleditsia peel extract 0.1%,
Abrasivus: silicon dioxide 35%, calcium carbonate 30%,
Coloring agent: titanium dioxide 0.5%,
Antiseptic: potassium sorbate 0.1%, water surplus.
Embodiment 6:
A kind of Chinese medicinal toothpaste, various raw material components proportionings are expressed as follows with percentage by weight %:
Chinese medicine beta-cyclodextrin inclusion compound Rabdosia rubescens powder 15.0%,
Binding agent: nanometer rheology thickener-silica 5%,
Flavouring agent: natural Fructus Citri tangerinae quintessence oil 1%,
Sweeting agent: xylitol 10.0%,
Wetting agent: sorbitol 45.0%,
Foaming agent: Fructus Gleditsia peel extract 1.5%, tea saponin 1.5%,
Abrasivus: silicon dioxide 5%, calcium carbonate 10%,
Coloring agent: titanium dioxide 1%,
Water surplus.
Embodiment 7:
The preparation method of the described Chinese medicinal toothpaste of embodiment of the invention 1-6:
Step 1: Rabdosia rubescens is ground into 30 orders, puts into the lixiviate jar, the ethanol of employing 55% heated 3 hours under 50 ℃ of counterflow conditions, and it is standby to fetch flow liquid;
Step 2: behind backflow distilling under reduced pressure recovery ethanol, add saturated beta-schardinger dextrin-and refluxed 10 hours down, promptly obtain buff powder, be beta-cyclodextrin inclusion compound Rabdosia rubescens powder through vacuum drying, pulverizing at 25 ℃;
Step 3: beta-cyclodextrin inclusion compound Rabdosia rubescens powder and other components be placed on disperse to mix in the agitator and be uniformly dispersed;
Step 4: said mixture outgased to stir under vacuum promptly gets Chinese medicinal toothpaste of the present invention.
Embodiment 8:
The preparation method of the described Chinese medicinal toothpaste of embodiment of the invention 1-6:
Step 1: Rabdosia rubescens is ground into 60 orders, puts into the lixiviate jar, adopt 95% ethanol, under 75 ℃ of counterflow conditions, heated 5 hours, promptly obtain backflow;
Step 2: behind backflow distilling under reduced pressure recovery ethanol, add saturated beta-schardinger dextrin-and refluxed 1 hour down, promptly obtain buff powder, be beta-cyclodextrin inclusion compound Rabdosia rubescens powder through vacuum drying, pulverizing at 75 ℃;
Step 3: beta-cyclodextrin inclusion compound Rabdosia rubescens powder and other components be placed on disperse to mix in the agitator and be uniformly dispersed;
Step 4: said mixture outgased to stir under vacuum promptly gets Chinese medicinal toothpaste of the present invention.
Embodiment 9: Chinese medicinal toothpaste of the present invention is to the inhibitory action of clinical bacteria
By detecting 26 strain gram-positive coccis, 34 strain gram negative bacilli, the result shows, the Chinese medicinal toothpaste of embodiment 1-6 preparation all has the obvious suppression effect to the former, Gram-positive pathogenic bacterium to oral cavity and respiratory tract, has significantly bacteriostasis as Staphyloccocus aureus, alpha streptococcus, escherichia coli, Diplococcus pneumoniae etc., contrast toothpaste does not then have tangible bacteriostasis to the Gram-positive of oral cavity and the respiratory tract bacterium of curing the disease, and illustrates that Chinese medicinal toothpaste fungistatic effect of the present invention is better.
Embodiment 10: Chinese medicinal toothpaste pain relieving of the present invention, haemostatic effect test
With the swelling of caused by dimethylbenzene xylene white mice auricle acute inflammation is model, is tried thing in acute inflammation swelling auricle partial smearing, observes the antiphlogistic effects of the Chinese medicinal toothpaste of embodiment of the invention 1-6 preparation to acute inflammation swelling; Bleeding stopping period with TWO organa parenchymatosum liver local woanded surface bleeding due to trauma is an evaluation index, observes the haemostatic effect of Chinese medicinal toothpaste of the present invention.The result: compare with the blank matrix group of toothpaste, the antiinflammatory of toothpaste test group, haemostatic effect all have significant difference, P＜0.05, and conclusion: Chinese medicinal toothpaste of the present invention has antiinflammatory haemostatic effect preferably.
Chinese medicinal toothpaste of the present invention suppresses acetic acid induced mice pain to a certain extent, but effect is than a little less than the indomethacin.But Chinese medicinal toothpaste increased platelets counts quantity of the present invention promotes platelet aggregation and increases thrombin activity, accelerates anastalsis by number of ways.
Embodiment 11: Chinese medicinal toothpaste of the present invention is to chronic pharyngolaryngitis, periodontal abscess and pericoronitis clinical efficacy
By the clinical use of Chinese medicinal toothpaste of embodiment of the invention 1-6 preparation, the gingiva inflammation disappears, and periodontal pocket shoals, and tooth mobility reduces, and illustrates that to periodontal abscess nuclear periodontitis be effective.Drug level height in periodontal pocket, the time of effect is longer, and anaerobe is had inhibitory action, and is without any side effects.
In the process of treatment chronic pharyngolaryngitis, use the Chinese medicinal toothpaste of embodiment of the invention 1-6 preparation, to the partial symptoms and the sign of chronic pharyngolaryngitis, as swallow painful, dry pharynx, itching throat, pharyngeal hyperemia and leaching bubble hypertrophy etc. certain curative effect arranged, and to the pharynx lateral bundle thicken, no positive effects such as vocal congestion.
Embodiment 12: Chinese medicinal toothpaste of the present invention is removed the clinical effectiveness of the exogenous mottle of tooth and is observed
In test with 3 groups of crowds, one group of any Chinese medicinal toothpaste that uses embodiment of the invention 1-6 preparation, 2 groups are used other toothpaste in addition, and test is got off, and uses crowd's tooth of Chinese medicinal toothpaste of the present invention can effectively reduce the teeth stains area.
Method: by plaque distribution situation, screen suitable volunteer, have 60 suitable objects to be divided into three groups at random with initial plaque index with 6 index teeth of improvement Navy plaque index records such as Rustugi.Volunteer's one week back further consultation, the various oral cavity cleaning measures of forbidding in the 24h before the further consultation.During check, every group is used specified toothpaste toothbrush to brush teeth respectively, and brushing time is 60s, detects dental plaque respectively before brushing teeth and before and after brushing teeth.Found that removing bacterial plaque after three groups of toothpaste of use are brushed teeth all has remarkable result (P＜0.05), in the whole district, the gum edge, adjacent dentes diastema plaque index is analyzed: the Chinese medicinal toothpaste of the embodiment of the invention 1-6 preparation back of brushing teeth is removed the bacterial plaque effect and is compared after brushing teeth 4h with other toothpaste there were significant differences, plaque index exceeds 34.8% respectively, 31.3%, 36.52%.Conclusion: Chinese medicinal toothpaste of the present invention is removed the bacterial plaque effect and is compared with other toothpaste that there were significant differences at the 4h that brushes teeth afterwards.
Embodiment 13: the skin irritation test of Chinese medicinal toothpaste of the present invention
Select 33 health volunteers for use, 13 of men, 20 of woman, age is at 21-60 between year, Chinese medicinal toothpaste with reference to many embodiment of the invention of GB7919-87 acute skin irritation test method 1-6 preparation detects, press GB7919-87 skin irritation evaluation criterion, the Chinese medicinal toothpaste nonirritant of embodiment of the invention 1-6 preparation.
The efficacy analysis of embodiment 14, the clinical use of Chinese medicinal toothpaste of the present invention is summed up
The Chinese medicinal toothpaste of embodiment of the invention 1-6 preparation detects by 6 months clinical double blind randoms, plaque index, gingival index etc. (P＞0.05), and sulcular bleeding index has been compared significant difference (0.01＞P＜0.05) with other toothpaste of use, gingival index with use toothpaste before compare and highly significant difference all arranged (P＜0.01).
Clinical detection shows that plaque index is reduced to 66 people (83.54%) among 79 experimenters that use Rabdosia rubescens toothpaste, and its decline mean is 25.6%; Sulcular bleeding index drops to 77 people (97.47%), and its decline mean is 51.9%; Gingival index drops to 75 people (94.93%).
Embodiment 14: Chinese medicinal toothpaste of the present invention is removed the clinical analysis of teeth stains
The clinical research methods of double blinding, layering, two unit parallel observations is adopted in this research.91 teeth have the experimenter of exogenous mottle to participate in this research, and the age is 18～55 years old.According to Lobene mottle index mean, sex, smoking habit it is divided into two groups evenly.Be divided at random test group and the time according to the group.
Teeth stains adopts Lobene mottle index (Lobene stain index method) to estimate, and estimates the size and the mottle degree (table 1) at mottle position with 0～3 numeral.Teeth stains adopts Lobene mottle index to estimate, and this index is estimated the size and the mottle degree at mottle position with 0～3 numeral.There is meter 0 in no mottle, and mottle exists size to be no more than facing 1/3 1, and degree is slight mottle (yellow or yellowish-brown) meter 1.Between score 0 and 1, promptly between the having and do not have of mottle, exponential measurement does not have than subfractionation.
Lobene mottle index classification score:
0: no mottle exists no mottle to exist
1: mottle is no more than 1/3 of facing, slight mottle (yellow or yellowish-brown)
2: mottle is no more than 2/3 of facing, moderate mottle (moderate is brown)
3: mottle is greater than 2/3 of facing, severe mottle (dark-brown or black)
Test group toothpaste is the Chinese medicinal toothpaste of embodiment of the invention 1-6 preparation, and matched group toothpaste is not then for containing the toothpaste with fluoride of the speckle composition that discolors.All toothpaste is all consistent on packing and color, with the double blinding of guaranteeing to study.The experimenter all issues same soft bristle tooth brush.Require the experimenter to brush teeth every day twice (each 1 time sooner or later), 1min brushes teeth at every turn; And require the experimenter to keep at ordinary times other oral sanitary habits, customs such as diet and smoking.Clinical examination is in baseline, the 4th week and carried out in the 8th week, and is finished by the same examiner.Statistical analysis is carried out in The data t check, two-sided test, and inspection level α is 0.05.
Participate in experimenter's baseline inspection of this research, the mottle index mean of matched group is 2.66, and test group is 2.64, and the t check shows no difference of science of statistics between the two.In the 8th week, the mottle index mean of matched group is 1.67, and test group is 1.05; Compare with matched group, the mottle index mean of test group has reduced by 37.1%, and analyzing by statistics has significant difference (P=0.0001).
| Group | ??n | The mottle index | Mean |
| Test group | ??42 | ??2.64±1.20 | ??1.05±0.69 |
| Matched group | ??44 | ??2.65±1.25 | ??1.67±0.99 |
The result of this research proves, test group is being brushed teeth twice with each Chinese medicinal toothpaste of embodiment of the invention 1-6 preparation every day, after using for 8 weeks, use the matched group that does not contain the toothpaste with fluoride of removing the mottle composition, the size of the exogenous mottle of facing and degree all have remarkable reduction on clinical examination and statistical analysis.
Conclusion: not only Pear Power effect of Chinese medicinal toothpaste of the present invention, effectively suppress the formation of bacterial plaque, and has an analgesic hemostatic effect, can improve chronic pharyngolaryngitis, periodontal abscess all inflammation shapes of coming of age, promote the health of periodontal tissue, to the skin nonirritant, be a kind of Chinese medicinal toothpaste with health role, be with a wide range of applications.
Claims (11)
1. Chinese medicinal toothpaste, its component comprises by weight percentage:
Beta-cyclodextrin inclusion compound Rabdosia rubescens powder 0.5%-15.0%
Binding agent 0.1%-5.0%
Wetting agent 8.0%-45.0%
Foaming agent 0.1%-3.0%
Silicon dioxide 5.0%-35.0%
Calcium carbonate 10.0%-50.0%.
2. according to right 1 described Chinese medicinal toothpaste, it is characterized in that, also comprise emulsifying agent, coloring agent, sweeting agent, flavouring agent or antiseptic.
3. according to claim 1 or 2 described Chinese medicinal toothpastes, it is characterized in that described binding agent is a nanometer rheology thickening agent, is preferably nanometer grade silica or Nano titanium dioxide.
4. according to claim 1 or 2 described Chinese medicinal toothpastes, it is characterized in that described foaming agent is Herba Cassiae Nomamis peel extract or tea saponin.
5. according to the described Chinese medicinal toothpaste of claim 2, it is characterized in that described emulsifying agent is the lecithin that accounts for toothpaste weight 0.1%-5.0%.
6. according to the described Chinese medicinal toothpaste of claim 2, it is characterized in that described coloring agent is the titanium dioxide that accounts for toothpaste weight 0.5%-5.0%.
7. according to the described Chinese medicinal toothpaste of claim 2, it is characterized in that described sweeting agent is the xylitol that accounts for toothpaste weight 0.1%-10.0%.
8. according to the described Chinese medicinal toothpaste of claim 2, it is characterized in that described flavouring agent is the natural Fructus Citri tangerinae quintessence oil that accounts for toothpaste weight 0.1%-1.0%, natural Herba Menthae quintessence oil or natural spearmint essential oil.
9. according to the described Chinese medicinal toothpaste of claim 2, it is characterized in that described antiseptic is the potassium sorbate that accounts for toothpaste weight 0.1%-1.0%.
10. the preparation method of each described Chinese medicinal toothpaste of claim 1-8 comprises following steps:
Step 1: Rabdosia rubescens is ground into the 30-60 order, adds the ethanol of 55%-95%, at 50-75 ℃ of backflow 3-5 hour, it was standby to fetch flow liquid;
Step 2: behind backflow distilling under reduced pressure recovery ethanol, add saturated beta-schardinger dextrin-and reflux, obtain buff powder through vacuum drying, pulverizing again, be beta-cyclodextrin inclusion compound Rabdosia rubescens powder;
Step 3: beta-cyclodextrin inclusion compound Rabdosia rubescens powder and other components are mixed and be uniformly dispersed;
Step 4: said mixture outgased to stir under vacuum promptly gets Chinese medicinal toothpaste of the present invention.
11. preparation method according to claim 10 is characterized in that, the described backflow of step 2 is at 25 ℃ of-75 ℃ of following backflow 1-10 hours.
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| RU2455975C2 (en) * | 2010-10-19 | 2012-07-20 | Олег Анатольевич Бобров | Toothpaste |
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| CN1436522A (en) * | 2002-02-06 | 2003-08-20 | 尤国宝 | Biological toothpaste |
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| CN103751269A (en) * | 2014-01-09 | 2014-04-30 | 黄河科技学院 | Application of herba rabdosiae rubescentis extract to alpha-glucosidase inhibitor |
| CN103751269B (en) * | 2014-01-09 | 2016-08-17 | 黄河科技学院 | Rabdosia rubescens extract application in alpha-glucosidase inhibitor |
| CN103989618A (en) * | 2014-05-13 | 2014-08-20 | 青岛华仁技术孵化器有限公司 | Toothpaste used for treating gingivitis and preparation method thereof |
| CN104666113A (en) * | 2015-03-06 | 2015-06-03 | 徐饶春 | Toothpaste thickener |
| CN106309173A (en) * | 2015-06-16 | 2017-01-11 | 赵丹青 | Pure natural mouthwash and preparation method thereof |
| CN106726967A (en) * | 2016-12-27 | 2017-05-31 | 郑州游爱网络技术有限公司 | A kind of function toothpaste for carcinoma of mouth rehabilitation and preparation method thereof |
| CN106727135A (en) * | 2016-12-27 | 2017-05-31 | 郑州游爱网络技术有限公司 | A kind of mouthwash for carcinoma of mouth rehabilitation and preparation method thereof |
| CN107362056A (en) * | 2017-07-05 | 2017-11-21 | 汪锦川 | A kind of manufacture of green functional health toothpaste and processing technology |
| CN107929192A (en) * | 2017-11-13 | 2018-04-20 | 常州凯恒纺织品有限公司 | A kind of antiallergic sense toothpaste |
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