CN103599029B - Anti-inflammation compositions, talcum powder and preparation method thereof - Google Patents
Anti-inflammation compositions, talcum powder and preparation method thereof Download PDFInfo
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- CN103599029B CN103599029B CN201310631943.XA CN201310631943A CN103599029B CN 103599029 B CN103599029 B CN 103599029B CN 201310631943 A CN201310631943 A CN 201310631943A CN 103599029 B CN103599029 B CN 103599029B
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Abstract
The present invention relates to skin care field, particularly anti-inflammation compositions, talcum powder and preparation method thereof.This anti-inflammation compositions comprises beta-cyclodextrin inclusion compound Rabdosia rubescens powder and marine organism extract; The preparation method of beta-cyclodextrin inclusion compound Rabdosia rubescens powder is: get Rabdosia rubescens and ethanol water mixing, through alcohol extraction, obtain Rabdosia rubescens alcohol extract; Get Rabdosia rubescens alcohol extract, remove ethanol, mix with beta-schardinger dextrin-, through rectification, drying, pulverizing, to obtain final product; Marine organism extract is chitosan and/or chitin.Anti-inflammation compositions provided by the invention effectively can treat Diaper Dermatitis of Newborn; Talcum powder formula material provided by the invention is all edible natural component, non-stimulated to skin, there is unique pro-skin damping, salubrious function, there is the effect that antibacterial, antiinflammatory, infection, heat-clearing and toxic substances removing, eliminating dampness by diuresis are antipruritic, simultaneously to preventing infantile eczema, miliaria etc. from having specific effect.
Description
Technical field
The present invention relates to skin care field, particularly anti-inflammation compositions, talcum powder and preparation method thereof.
Background technology
The skin of infant is more tender and lovely, and thickness only has 1/10 of adult skin, is easy to breakage when being rubbed or stimulate, and the immunologic function of skin is not also grown perfect in addition, and resistance is more weak, is upset and is easy to produce inflammation.Infant used diaper not at that time, as easy as rolling off a log initiation diaper dermatitis.Diaper dermatitis, also referred to as diaper rash or baby's diaper dermatitis, there is flushing, erythra in the skin showing as buttocks and diaper contact area, even occurs festering and infecting.In order to maintain the dry and comfortable of infant skin, to prevent diaper dermatitis, usually infant after a bath after, talcum powder is spread upon buttocks or other position of health.Therefore, in the process of nursing infant, the use of talcum powder is very general.
Child's talcum powder that current most of market is sold mainly contains 3 kinds, is respectively based on the talcum powder of Pulvis Talci, Margarita powder or natural plants.Wherein, the talcum powder based on Pulvis Talci, it is aided with zinc stearate, magnesium stearate, lanolin alcohol, glyceryl monostearate, fibroin, silk peptide, boric acid and essence again and obtains, and this child's talcum powder is product very general in the market.Pulvis Talci is crushed and screened and a kind of chemical powder of comminution by gas stream by natural minerals crystalline substance, is widely used in environment-friendly type coating, paint, adult cosmetics and child's talcum powder.But containing inseparable lead in Pulvis Talci, and Pulvis Talci easily flies upward, and uses middle meeting to suck through mouth and nose, because infant is weak for the excretory function of lead, lead enters after in infants and can not be drained very soon.In infants, μ g/L in blood lead >=100 is lead poisoning, and lead is accumulated for a long time when human body, will endanger nerve, hemopoietic system and digestive system, has a strong impact on intelligence and the body development of infant.So the child's talcum powder based on Pulvis Talci is harmful for the body development of infant.
Child's talcum powder based on Margarita powder, its be aided with again Pulvis Talci, zinc oxide, zinc stearate, essence, Mentholum, Oleum menthae, Camphora, salicylic acid, Radix Stephaniae Cepharanthae powder, ammonium glycyrrhizinate, methyl hydroxybenzoate obtain.The main component of Margarita powder is calcium carbonate, easily invades respiratory tract, because the respiratory tract of infant is grown not perfect, even if suction volume can not lean on self function to get rid of less.If suction volume is many, invades the ciliary movement of bronchial ravages trachea, will phylactic power defensive power be reduced, easily bring out respiratory tract infection.Therefore, the child's talcum powder based on Margarita powder remains unsafe for the body development of infant.
Take natural plants as child's talcum powder of main component, be mainly the child's talcum powder based on Semen Maydis powder, rice meal, this series products is aided with Chinese herbal medicine and natural bran powder mostly, plant unfresh towel gourd is dry, Aloe is dry, Rose Blume Getrocknete etc. obtains, and is a kind of safe and harmless child's talcum powder.At present, be that the kind of child's talcum powder of main component is less with natural plants, therefore provide a kind of novel, safe and effective child's talcum powder to have important practical significance.
Summary of the invention
In view of this, the invention provides anti-inflammation compositions, talcum powder and preparation method thereof.This anti-inflammation compositions effectively can treat Diaper Dermatitis of Newborn, is evident in efficacyly better than beta-cyclodextrin inclusion compound Rabdosia rubescens powder single dose and marine organism extract single dose.The formula material of this talcum powder is all edible natural component, non-stimulated to skin, there is unique pro-skin damping, salubrious function, there is the effect that antibacterial, antiinflammatory, infection, heat-clearing and toxic substances removing, eliminating dampness by diuresis are antipruritic, simultaneously to preventing infantile eczema, miliaria etc. from having specific effect.
In order to realize foregoing invention object, the invention provides following technical scheme:
The invention provides a kind of anti-inflammation compositions, comprise beta-cyclodextrin inclusion compound Rabdosia rubescens powder and marine organism extract;
The preparation method of beta-cyclodextrin inclusion compound Rabdosia rubescens powder is: get Rabdosia rubescens and ethanol water mixing, through alcohol extraction, obtain Rabdosia rubescens alcohol extract; Get Rabdosia rubescens alcohol extract, remove ethanol, mix with beta-schardinger dextrin-, through rectification, drying, pulverizing, to obtain final product;
Marine organism extract is chitosan and/or chitin.
Rabdosia rubescens has another name called Rabdosia rubescens, is that Labiatae scented tea belongs to, perennial herb or undershrub, undershrub, is that Labiatae Rabdosia plant is cracked rice fork mutation.Medicinal part is Herb, nature and flavor are bitter, sweet, be slightly cold, there is heat-clearing and toxic substances removing, anti-inflammatory analgetic, stomach invigorating invigorated blood circulation, antibacterial, antitumor, antiviral, anti-inflammation, immunostimulant, antioxidation, mutation, the effect such as blood pressure lowering, cure mainly laryngopharynx swelling and pain, tonsillitis, headache due to common cold, tracheitis, chronic hepatitis, articular rheumatic pain, snake bite and insect sting, have mitigation to the esophageal carcinoma, breast carcinoma, rectal cancer etc.The chemical analysis of Rabdosia rubescens is very complicated, wherein containing compositions such as volatile oil, terpene substances, alkaloid, steroidal, flavone, lactone, organic acid, aminoacid, monosaccharide, Saponin, Amyrin, isorhamnetin, chlorophylls, also containing inorganic elements ferrum, zinc, manganese, copper, chromium, nickel, cobalt, molybdenum, selenium and other trace elements.Rabdosia rubescens is described as " green antibiotic ", " paclitaxel second ".In the present invention, beta-cyclodextrin inclusion compound Rabdosia rubescens powder is the effective ingredient obtained by molecule inclusion technology in Rabdosia rubescens, can effective slow release during application.
Marine organism extract in the present invention is chitosan and/or chitin.Chitin has another name called chitin, chitin, and it is present in lower animal, particularly arthropodan carapace in a large number, and chemical name is (Isosorbide-5-Nitrae)-2-acetylaminohydroxyphenylarsonic acid 2-deoxidation-callose, is a kind of linear biopolymer.The Main Derivatives of chitin is the product-chitosan after chitin removes acetyl group; have another name called soluble chitin, chitosan or chitosan; pure chitosan is white or translucent chip solid, slightly pearly luster, is the third-largest living resources of the mankind except starch, cellulose.Chitin or chitosan have broad spectrum antibiotic activity, obvious fungistatic effect is all had to gram positive bacteria, negative bacterium and Candida albicans, treatment for wound has multiple excellent properties, and zoopery shows its inanimate object toxicity, is suitable as very much the raw material of wound dressing.Chitin and multiple derivant thereof all have anti-infectious function in various degree.Wherein, chitosan has protonated ammonium, protonated ammonium and the electronegative cell membrane effect of antibacterial, absorption and coagulation antibacterial, and penetration cell wall enters in cell simultaneously, the metabolism of upset antibacterial and synthesis and have antibacterial action.Research shows that it is all high by more than 99% to the bacteriostasis rate of golden Fructus Vitis viniferae, escherichia coli, Candida albicans, and antibacterial action and deodorization is remarkable simultaneously.
Shown by research, evident in efficacy in antiinflammatory disappears bacterium of the anti-inflammation compositions comprising beta-cyclodextrin inclusion compound Rabdosia rubescens powder and marine organism extract provided by the invention, effectively can treat Diaper Dermatitis of Newborn, it is evident in efficacy is better than beta-cyclodextrin inclusion compound Rabdosia rubescens powder single dose and marine organism extract single dose.
As preferably, the mass ratio of beta-cyclodextrin inclusion compound Rabdosia rubescens powder and marine organism extract is (2 ~ 10): (1 ~ 12).
As preferably, marine organism extract is chitosan.
In embodiments more provided by the invention, chitosan is Nano chitosan (ultra-fine chitosan).
In embodiments more provided by the invention, ultra-fine chitosan adopts the snow Carapax Eriocheir sinensis at deep-sea to be that raw material obtains through enzymatic degradation.
In embodiments more provided by the invention, chitin is nano-chitosan (ultrafine chitin).
As preferably, the concentration of ethanol water is 55% ~ 95%.
In order to ensure that the effective ingredient in Rabdosia rubescens is extracted fully, in embodiments more provided by the invention, the temperature of alcohol extraction is 50 ~ 75 DEG C.
In order to ensure that the effective ingredient in Rabdosia rubescens is extracted fully, in embodiments more provided by the invention, the time of alcohol extraction is 3 ~ 5h.
Present invention also offers this anti-inflammation compositions and prepare the application in talcum powder or Diaper Dermatitis of Newborn medicine.
Present invention also offers a kind of talcum powder, its raw material comprises legume seeds, fragrant plant and anti-inflammation compositions provided by the invention.
This anti-inflammation compositions comprises beta-cyclodextrin inclusion compound Rabdosia rubescens powder and marine organism extract; The preparation method of beta-cyclodextrin inclusion compound Rabdosia rubescens powder is: get Rabdosia rubescens and ethanol water mixing, through alcohol extraction, obtain Rabdosia rubescens alcohol extract; Get Rabdosia rubescens alcohol extract, remove ethanol, mix with beta-schardinger dextrin-, through rectification, drying, pulverizing, to obtain final product; Marine organism extract is chitosan and/or chitin; As preferably, the mass ratio of beta-cyclodextrin inclusion compound Rabdosia rubescens powder and marine organism extract is (2 ~ 10): (1 ~ 12).
Proved by this beta-cyclodextrin inclusion compound Rabdosia rubescens power applications in talcum powder provided by the invention, not only have peculiar curative effect to the eczema of the unclean generation of child skin, pruritus, ulcer, chemical preservative can be substituted completely simultaneously by clinical trial.The present invention, according to the feature of infant skin, adds the appropriate chitosan that extracted from marine organisms housing by biological engineering or chitin as auxiliary element in talcum powder, can reach the effect of damping, moisturizing, salubrious, antibacterial anti-infection.Because chitin or chitosan have very strong close skin bioreactivity material, and specific surface area is large, porosity is high, absorb sebum quasi-grease much larger than starch or other active substances, so impose on the tender and lovely skin of infant, not only dehumidifying is salubrious, the effect of damping can also be reached, completely not cutaneous " breathing " function.Shown by research, evident in efficacy in antiinflammatory disappears bacterium of the talcum powder comprising beta-cyclodextrin inclusion compound Rabdosia rubescens powder and marine organism extract provided by the invention, effectively can treat Diaper Dermatitis of Newborn, its curative effect is better than beta-cyclodextrin inclusion compound Rabdosia rubescens powder single dose and marine organism extract single dose.
Adopt natural legume seeds as main powder body in the present invention, do not add the materials such as traditional Pulvis Talci containing heavy metal.Its nutritional labeling of these beans is very abundant, for Semen phaseoli radiati, its nutritive value is very high, every hectogram containing 22.1 grams, protein, 0.8 gram, fat, carbohydrate 4.5 grams, calcium 313 milligrams, 309 milligrams, phosphorus, ferrum 6.4 milligrams and crude fibre, and contains the abundant trace element such as aminoacid, carotene, phospholipid, thiamine, riboflavin.Legume seeds powder is added in talcum powder, the effect of Pulvis Talci, Margarita powder can be replaced, be a kind of natural, non-stimulated to skin composition, there is pro-skin damping, salubrious function.
The flavor component added in talcum powder provided by the invention derives from natural fragrant plant, is a kind of natural, safe, non-stimulated to skin flavor component.
As can be seen here, talcum powder provided by the invention is by adopting edible, nontoxic legume seeds as primary raw material, be equipped with marine organism extract-chitin or oligochitosan, and adopt a kind of beta-cyclodextrin inclusion compound Rabdosia rubescens powder of medicine-food two-purpose and natural flavor plant to be prepared into a kind of talcum powder.This formula material is all edible natural component, non-stimulated to skin, there is unique pro-skin damping, salubrious function, there is the effect that antibacterial, antiinflammatory, infection, heat-clearing and toxic substances removing, eliminating dampness by diuresis are antipruritic, simultaneously to preventing infantile eczema, miliaria etc. from having specific effect.
As preferably, the mass ratio of legume seeds, fragrant plant and anti-inflammation compositions provided by the invention is (60 ~ 95): (2 ~ 15): (3 ~ 22).
As preferably, legume seeds is selected from Semen Glycines, Semen phaseoli radiati, Semen Pisi sativi or Semen phaseoli radiati.
Preferably, legume seeds is Semen phaseoli radiati.Traditional medicine is thought, Semen phaseoli radiati is sweet in flavor and cold in property, nontoxic, have heat-clearing and toxic substances removing, drive away summer heat quench the thirst, effect of inducing diuresis to remove edema, improving acuity of vision and removing nebula, skin-care and beautifying.Especially clinically Semen phaseoli radiati powder is through different prescription, and for controlling, eczema miliaria, children's's furuncle and phyma, dermatitis, skin pruritus, impetigo, carbuncle sore furuncle and phyma, impetigo etc. are all effective.Semen phaseoli radiati powder also has the effect of clean skin, containing Concha Ostreae alkali and different Concha Ostreae alkali in Semen phaseoli radiati, has remarkable cleaning, moistening effect, removes sebum function remarkable, effectively can remove the unclean thing in skin, more can thoroughly remove deep skin refuse.The distinctive moisturizing ingredient of Semen phaseoli radiati and mineral, to skin supply adequate water, the moisture moisture-retaining capacity of efficient hardening skin, improves dry skin.
As preferably, fragrant plant is selected from Herba Menthae, Lemon Basil or Radix Oenotherae erythrosepalae.
Preferably, fragrant plant is Herba Menthae.Compendium of Material Medica is thought: Herba Menthae acrid in the mouth, cool in nature, nontoxic, can control abundant expectoration and various cold.Mentha leave is containing Oleum menthae (main component menthol, menthone), Herba Menthae cream, CAM, Fructus Citri Limoniae terpene, protein, fat, carbohydrate, mineral, vitamin.Herb contains volatile oil, and its main component is menthol (Menthol), menthone (Menthone), glycoside and multiple free amino acid.Have that dispelling wind and heat pathogens, clearing throat, rash are antipruritic, the effect of anti-inflammatory analgesic, commonly use this bathing summer, can eczema, miliaria etc. be prevented.The present invention adopts natural mentha leave through water soaking, cleaning, oven dry, vacuum drying, coarse pulverization, by pneumatic conveying drying, be added in baby powder, human body can be made to have refrigerant, comfortable sensation, this natural mentha leave is after shattering, fiber super-refinement in leaf, its reference area is very large, bestows on skin, not only can effectively adsorb various body odour, yet there is the effect of " pro-skin breathing ".
Present invention also offers the preparation method of this talcum powder, comprise the steps:
Get legume seeds, through the first pretreatment, first dry, the first pulverizing, obtain legume seeds powder;
Get fragrant plant, through the second pretreatment, second dry, the second pulverizing, obtain fragrant plant powder;
Get Rabdosia rubescens and ethanol water mixing, through alcohol extraction, obtain Rabdosia rubescens alcohol extract; Get Rabdosia rubescens alcohol extract, remove ethanol, mix with beta-schardinger dextrin-, through rectification, drying, pulverizing, obtain beta-cyclodextrin inclusion compound Rabdosia rubescens powder;
Obtain marine organism extract, marine organism extract is chitosan and/or chitin;
Get the mixing of legume seeds powder, fragrant plant powder, beta-cyclodextrin inclusion compound Rabdosia rubescens powder and marine organism extract, through the 3rd pulverizing, sieve, to obtain final product.
As preferably, the 3rd fineness pulverized is 100 ~ 325 orders.
In embodiments more provided by the invention, the first pretreatment is specially and is placed in water immersion, cleaning, centrifuge dripping.
Experiment proves, adopt subsoil water and tap water soak and wash legume seeds and fragrant plant, the chlorine residue in inspection tap water is absorbed completely, and soak time is longer and wash number is more, and the harmful element of attached ground water and tap water is more.Therefore, water used in pretreatment is preferably the water containing zinc ion, is by the rich zinc active-oxygen-water of the machine-processed mineralising obtained of mineralising rich zinc active-oxygen-water water.Mineralising rich zinc active-oxygen-water water machine adopts functionalization natural energy Ceramic Balls technology to obtain the solvent composition of the water containing zinc ion as oral cleaning nursing article, and functionalization natural energy Ceramic Balls technology can also calcium, magnesium ion in activated water.The rich zinc active-oxygen-water of mineralising be to tap water through 8 machine filter element filtering gained, be characterized in that there is subset water-bound, be rich in trace element and be especially rich in zinc ion, not containing heavy metal.Calcium ions and magnesium ions in tap water is further activated and non-scaling through the filtration of several filter element, is a kind of heavy-oxygen-enriched water with energy-activated mineralising.The present invention adopts this water to clean legume seeds and fragrant plant, because the two all has the very strong capillary pipe structure of absorbability, so, washed with dirt in mineralising rich zinc active-oxygen-water cleaning process, the beneficiating ingredient simultaneously in water is adsorbed in legume seeds and fragrant plant.
In embodiments more provided by the invention, containing in the water of zinc ion, the mass percentage of zinc is 0.5% ~ 1%.
In embodiments more provided by the invention, the first drying is carried out in vacuum drying oven.
In embodiments more provided by the invention, the first fineness pulverized is 60 orders.
In embodiments more provided by the invention, the second pretreatment is identical with the first pretreatment.
In embodiments more provided by the invention, second is dry dry identical with first.
In embodiments more provided by the invention, the second pulverizing and first is pulverized identical.
Present invention also offers one and treat Diaper Dermatitis of Newborn medicine, it comprises anti-inflammation compositions provided by the invention and pharmaceutically acceptable adjuvant; This anti-inflammation compositions comprises beta-cyclodextrin inclusion compound Rabdosia rubescens powder and marine organism extract; The preparation method of beta-cyclodextrin inclusion compound Rabdosia rubescens powder is: get Rabdosia rubescens and ethanol water mixing, through alcohol extraction, obtain Rabdosia rubescens alcohol extract; Get Rabdosia rubescens alcohol extract, remove ethanol, mix with beta-schardinger dextrin-, through rectification, drying, pulverizing, to obtain final product; Marine organism extract is chitosan and/or chitin; As preferably, the mass ratio of beta-cyclodextrin inclusion compound Rabdosia rubescens powder and marine organism extract is (2 ~ 10): (1 ~ 12); As preferably, marine organism extract is chitosan; In embodiments more provided by the invention, chitosan is Nano chitosan (ultra-fine chitosan); In embodiments more provided by the invention, ultra-fine chitosan adopts the snow Carapax Eriocheir sinensis at deep-sea to be that raw material obtains through enzymatic degradation; In embodiments more provided by the invention, chitin is nano-chitosan (ultrafine chitin); As preferably, the concentration of ethanol water is 55% ~ 95%; In embodiments more provided by the invention, the temperature of alcohol extraction is 50 ~ 75 DEG C; In embodiments more provided by the invention, the time of alcohol extraction is 3 ~ 5h.
The invention provides anti-inflammation compositions, talcum powder and preparation method thereof.This anti-inflammation compositions comprises beta-cyclodextrin inclusion compound Rabdosia rubescens powder and marine organism extract; The preparation method of beta-cyclodextrin inclusion compound Rabdosia rubescens powder is: get Rabdosia rubescens and ethanol water mixing, through alcohol extraction, obtain Rabdosia rubescens alcohol extract; Get Rabdosia rubescens alcohol extract, remove ethanol, mix with beta-schardinger dextrin-, through rectification, drying, pulverizing, to obtain final product; Marine organism extract is chitosan and/or chitin.Shown by clinical trial, anti-inflammation compositions provided by the invention effectively can treat Diaper Dermatitis of Newborn, is evident in efficacyly better than beta-cyclodextrin inclusion compound Rabdosia rubescens powder single dose and marine organism extract single dose.Talcum powder formula material provided by the invention is all edible natural component, non-stimulated to skin, there is unique pro-skin damping, salubrious function, there is the effect that antibacterial, antiinflammatory, infection, heat-clearing and toxic substances removing, eliminating dampness by diuresis are antipruritic, simultaneously to preventing infantile eczema, miliaria etc. from having specific effect.
Detailed description of the invention
The invention discloses anti-inflammation compositions, talcum powder and preparation method thereof, those skilled in the art can use for reference present disclosure, and suitable improving technique parameter realizes.Special needs to be pointed out is, all similar replacements and change apparent to those skilled in the art, they are all deemed to be included in the present invention.Method of the present invention and application are described by preferred embodiment, related personnel obviously can not depart from content of the present invention, spirit and scope methods and applications as herein described are changed or suitably change with combination, realize and apply the technology of the present invention.
In anti-inflammation compositions provided by the invention, talcum powder and preparation method thereof, raw materials used or adjuvant all can be buied by market.Wherein, ultra-fine oligochitosan or ultrafine chitin are the snow Carapax Eriocheir sinensis at employing deep-sea, Bo Zhihui power bio tech ltd, Qingdao of National Marine Medicine Engineering Technology Research Center is that raw material obtains through enzymatic degradation.
Below in conjunction with embodiment, set forth the present invention further:
The preparation of embodiment 1 anti-inflammation compositions
The formula of anti-inflammation compositions is in table 1.
The formula of table 1 anti-inflammation compositions
| Supplementary material title | Formula ratio (kg) |
| Beta-cyclodextrin inclusion compound Rabdosia rubescens powder | 2.5 |
| Ultra-fine chitosan | 2.5 |
The preparation method of beta-cyclodextrin inclusion compound Rabdosia rubescens powder is: Rabdosia rubescens is crushed to 30 orders, adds 95% ethanol water, and reflux 3h under the condition of 75 DEG C, obtains Rabdosia rubescens alcohol extract; After getting Rabdosia rubescens alcohol extract distilling under reduced pressure removal ethanol, add saturated beta-schardinger dextrin-backflow, through vacuum drying, pulverizing, cross 60 mesh sieves stand-by.
It is stand-by that 60 mesh sieves crossed by ultra-fine chitosan.
By obtained beta-cyclodextrin inclusion compound Rabdosia rubescens powder, the mixing of ultra-fine chitosan, to obtain final product.
The preparation of embodiment 2 anti-inflammation compositions
The formula of anti-inflammation compositions is in table 2.
The formula of table 2 anti-inflammation compositions
| Supplementary material title | Formula ratio (kg) |
| Beta-cyclodextrin inclusion compound Rabdosia rubescens powder | 3.5 |
| Ultra-fine chitosan | 4.5 |
The preparation method of beta-cyclodextrin inclusion compound Rabdosia rubescens powder is: Rabdosia rubescens is crushed to 40 orders, adds 90% ethanol water, and reflux 3.5h under the condition of 70 DEG C, obtains Rabdosia rubescens alcohol extract; After getting Rabdosia rubescens alcohol extract distilling under reduced pressure removal ethanol, add saturated beta-schardinger dextrin-backflow, through vacuum drying, pulverizing, cross 60 mesh sieves stand-by.
It is stand-by that 60 mesh sieves crossed by ultra-fine chitosan.
By obtained beta-cyclodextrin inclusion compound Rabdosia rubescens powder, the mixing of ultra-fine chitosan, to obtain final product.
The preparation of embodiment 3 anti-inflammation compositions
The formula of anti-inflammation compositions is in table 3.
The formula of table 3 anti-inflammation compositions
| Supplementary material title | Formula ratio (kg) |
| Beta-cyclodextrin inclusion compound Rabdosia rubescens powder | 4.5 |
| Ultra-fine chitosan | 6.5 |
The preparation method of beta-cyclodextrin inclusion compound Rabdosia rubescens powder is: Rabdosia rubescens is crushed to 50 orders, adds 80% ethanol water, and reflux 4h under the condition of 65 DEG C, obtains Rabdosia rubescens alcohol extract; After getting Rabdosia rubescens alcohol extract distilling under reduced pressure removal ethanol, add saturated beta-schardinger dextrin-backflow, through vacuum drying, pulverizing, cross 60 mesh sieves stand-by.
It is stand-by that 60 mesh sieves crossed by ultra-fine chitosan.
By obtained beta-cyclodextrin inclusion compound Rabdosia rubescens powder, the mixing of ultra-fine chitosan, to obtain final product.
The preparation of embodiment 4 anti-inflammation compositions
The formula of anti-inflammation compositions is in table 4.
The formula of table 4 anti-inflammation compositions
| Supplementary material title | Formula ratio (kg) |
| Beta-cyclodextrin inclusion compound Rabdosia rubescens powder | 2 |
| Ultrafine chitin | 12 |
The preparation method of beta-cyclodextrin inclusion compound Rabdosia rubescens powder is: Rabdosia rubescens is crushed to 55 orders, adds 70% ethanol water, and reflux 4.5h under the condition of 60 DEG C, obtains Rabdosia rubescens alcohol extract; After getting Rabdosia rubescens alcohol extract distilling under reduced pressure removal ethanol, add saturated beta-schardinger dextrin-backflow, through vacuum drying, pulverizing, cross 60 mesh sieves stand-by.
It is stand-by that ultrafine chitin crosses 60 mesh sieves.
By obtained beta-cyclodextrin inclusion compound Rabdosia rubescens powder, ultrafine chitin mixing, to obtain final product.
The preparation of embodiment 5 anti-inflammation compositions
The formula of anti-inflammation compositions is in table 5.
The formula of table 5 anti-inflammation compositions
| Supplementary material title | Formula ratio (kg) |
| Beta-cyclodextrin inclusion compound Rabdosia rubescens powder | 10 |
| Ultrafine chitin | 1 |
The preparation method of beta-cyclodextrin inclusion compound Rabdosia rubescens powder is: Rabdosia rubescens is crushed to 60 orders, adds 55% ethanol water, and reflux 5h under the condition of 50 DEG C, obtains Rabdosia rubescens alcohol extract; After getting Rabdosia rubescens alcohol extract distilling under reduced pressure removal ethanol, add saturated beta-schardinger dextrin-backflow, through vacuum drying, pulverizing, cross 60 mesh sieves stand-by.
It is stand-by that ultrafine chitin crosses 60 mesh sieves.
By obtained beta-cyclodextrin inclusion compound Rabdosia rubescens powder, ultrafine chitin mixing, to obtain final product.
Embodiment 6 clinical trial
Stochastic choice diaper dermatitis baby 120 example, is divided into three groups at random, often organizes 40 examples.Test is divided into matched group and test group.Matched group is divided into the first matched group and the second matched group, and the first matched group adopts the obtained beta-cyclodextrin inclusion compound Rabdosia rubescens powder single dose of embodiment 1 to treat, and the ultra-fine chitosan single dose that the second matched group adopts embodiment 1 to provide is treated.The anti-inflammation compositions treatment that test group adopts the embodiment of the present invention 1 to 5 obtained.
The drug dose of test group and matched group is 5g, one day 3 ~ 5 times, treats 5 days altogether, and treatment terminates rear observe the curative effect.
The evaluation criterion of Diaper Dermatitis of Newborn curative effect is:
1, effective: red and swollen, pain disappears, and skin sepage obviously improves, and rotten to the corn face and ulcer surface reduce;
2, invalid: redness, pain and skin sepage make moderate progress, but rotten to the corn face and (or) the ulcer surface person of being not improved.
The result of observation of curative effect is as shown in table 6.
Table 6 observation of curative effect result
From the result of the test of table 6, the treated effect 90.0% of beta-cyclodextrin inclusion compound Rabdosia rubescens powder single dose, the treated effect 80.0% of ultra-fine chitosan single dose, the anti-inflammation compositions treated effect that embodiment 1 obtains is 95.0%.The data of test group compare with the data of the second matched group, significant difference (P<0.05), and test group compares with the first matched group, and invalid number of cases and effective percentage all have significant difference (P<0.05).As can be seen here, the anti-inflammation compositions that the embodiment of the present invention 1 is obtained is better than beta-cyclodextrin inclusion compound Rabdosia rubescens powder single dose and ultra-fine chitosan single dose in treatment the evident in efficacy of Diaper Dermatitis of Newborn.
The anti-inflammation compositions that Example 2 to 5 obtains carries out the test for the treatment of Diaper Dermatitis of Newborn, the curative effect of the anti-inflammation compositions that result and embodiment 1 obtain is close, shows that the anti-inflammation compositions that the embodiment of the present invention 2 to 5 obtains is better than beta-cyclodextrin inclusion compound Rabdosia rubescens powder single dose and marine organism extract single dose in treatment the evident in efficacy of Diaper Dermatitis of Newborn.
As can be seen here, anti-inflammation compositions provided by the invention is evident in efficacyly better than beta-cyclodextrin inclusion compound Rabdosia rubescens powder single dose and marine organism extract single dose in treatment Diaper Dermatitis of Newborn.
The preparation of embodiment 7 talcum powder
The formula of talcum powder is in table 7.
The formula of table 7 talcum powder
| Kind | Supplementary material title | Formula ratio (kg) |
| Ingredient | The anti-inflammation compositions that embodiment 1 provides | 5 |
| Legume seeds | Semen phaseoli radiati powder | 88 |
| Fragrant plant | Mentha leave powder | 7 |
The preparation method of Semen phaseoli radiati powder is: adopt gather in the crops then, the uniform Semen phaseoli radiati of full grains, soak through the rich zinc active-oxygen-water of mineralising, cleaning, centrifuge dripping, proceeds in vacuum drying oven dry, through coarse pulverization, crosses 60 mesh sieves stand-by.
The preparation method of mentha leave powder is: adopt the mentha leave in good time plucked then, and through the rich zinc active-oxygen-water immersion of mineralising, cleaning, centrifuge dripping, proceeds in vacuum drying oven dry, through coarse pulverization, crosses 60 mesh sieves stand-by.
Semen phaseoli radiati powder, mentha leave powder are mixed homogeneously with the anti-inflammation compositions that embodiment 1 provides, pulverize through jet mill, cross 100 mesh sieves, fill, to obtain final product.
The preparation of embodiment 8 talcum powder
The formula of talcum powder is in table 8.
The formula of table 8 talcum powder
The preparation method of analysis for soybean powder is: adopt gather in the crops then, the uniform Semen Glycines of full grains, soak through the rich zinc active-oxygen-water of mineralising, cleaning, centrifuge dripping, proceeds in vacuum drying oven dry, through coarse pulverization, crosses 60 mesh sieves stand-by.
The preparation method of mentha leave powder is: adopt the mentha leave in good time plucked then, and through the rich zinc active-oxygen-water immersion of mineralising, cleaning, centrifuge dripping, proceeds in vacuum drying oven dry, through coarse pulverization, crosses 60 mesh sieves stand-by.
Anti-inflammation compositions mix homogeneously analysis for soybean powder, mentha leave powder and embodiment 2 provided, pulverizes through jet mill, and cross 150 mesh sieves, fill, to obtain final product.
The preparation of embodiment 9 talcum powder
The formula of talcum powder is in table 9.
The formula of table 9 talcum powder
The preparation method of peameal is: adopt gather in the crops then, the uniform Semen Pisi sativi of full grains, soak through the rich zinc active-oxygen-water of mineralising, cleaning, centrifuge dripping, proceeds in vacuum drying oven dry, through coarse pulverization, crosses 60 mesh sieves stand-by.
The preparation method of mentha leave powder is: adopt the mentha leave in good time plucked then, and through the rich zinc active-oxygen-water immersion of mineralising, cleaning, centrifuge dripping, proceeds in vacuum drying oven dry, through coarse pulverization, crosses 60 mesh sieves stand-by.
Anti-inflammation compositions mix homogeneously peameal, mentha leave powder and embodiment 3 provided, pulverizes through jet mill, and cross 200 mesh sieves, fill, to obtain final product.
The preparation of embodiment 10 talcum powder
The formula of talcum powder is in table 10.
The formula of table 10 talcum powder
The preparation method of green soya bean flour is: adopt gather in the crops then, the uniform Semen phaseoli radiati of full grains, soak through the rich zinc active-oxygen-water of mineralising, cleaning, centrifuge dripping, proceeds in vacuum drying oven dry, through coarse pulverization, crosses 60 mesh sieves stand-by.
The preparation method of Lemon Basil powder is: adopt the Lemon Basil in good time plucked then, and through the rich zinc active-oxygen-water immersion of mineralising, cleaning, centrifuge dripping, proceeds in vacuum drying oven dry, through coarse pulverization, crosses 60 mesh sieves stand-by.
Anti-inflammation compositions mix homogeneously green soya bean flour, Lemon Basil powder and embodiment 4 provided, pulverizes through jet mill, and cross 250 mesh sieves, fill, to obtain final product.
The preparation of embodiment 11 talcum powder
The formula of talcum powder is in table 11.
The formula of table 11 talcum powder
The preparation method of analysis for soybean powder is: adopt gather in the crops then, the uniform Semen Glycines of full grains, soak through the rich zinc active-oxygen-water of mineralising, cleaning, centrifuge dripping, proceeds in vacuum drying oven dry, through coarse pulverization, crosses 60 mesh sieves stand-by.
The preparation method of Radix Oenotherae erythrosepalae powder is: adopt the Lemon Basil in good time plucked then, and through the rich zinc active-oxygen-water immersion of mineralising, cleaning, centrifuge dripping, proceeds in vacuum drying oven dry, through coarse pulverization, crosses 60 mesh sieves stand-by.
Anti-inflammation compositions mix homogeneously analysis for soybean powder, Radix Oenotherae erythrosepalae powder and embodiment 5 provided, pulverizes through jet mill, and cross 325 mesh sieves, fill, to obtain final product.
Embodiment 12 treats the preparation of Diaper Dermatitis of Newborn medicine
The anti-inflammation compositions that getting the embodiment of the present invention 1 provides mixes with customary adjuvant, conventionally prepares medicine.
The above is only the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, under the premise without departing from the principles of the invention; can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Claims (9)
1. an anti-inflammation compositions, is characterized in that, is made up of beta-cyclodextrin inclusion compound Rabdosia rubescens powder and marine organism extract;
The preparation method of described beta-cyclodextrin inclusion compound Rabdosia rubescens powder is: get Rabdosia rubescens and ethanol water mixing, through alcohol extraction, obtain Rabdosia rubescens alcohol extract; Get described Rabdosia rubescens alcohol extract, remove ethanol, mix with beta-schardinger dextrin-, through rectification, drying, pulverizing, to obtain final product;
Described marine organism extract is chitosan and/or chitin;
The mass ratio of described beta-cyclodextrin inclusion compound Rabdosia rubescens powder and described marine organism extract is (2 ~ 10): (1 ~ 12).
2. anti-inflammation compositions as claimed in claim 1 is preparing the application in talcum powder or treatment Diaper Dermatitis of Newborn medicine.
3. a talcum powder, is characterized in that, its raw material comprises legume seeds, fragrant plant and anti-inflammation compositions as claimed in claim 1.
4. talcum powder according to claim 3, it is characterized in that, the mass ratio of described legume seeds, described fragrant plant and anti-inflammation compositions as claimed in claim 1 is (60 ~ 95): (2 ~ 15): (3 ~ 22).
5. talcum powder according to claim 3, is characterized in that, described legume seeds is selected from Semen Glycines, Semen phaseoli radiati, Semen Pisi sativi or Semen phaseoli radiati.
6. talcum powder according to claim 3, is characterized in that, described fragrant plant is selected from Herba Menthae, Lemon Basil or Radix Oenotherae erythrosepalae.
7. the preparation method of talcum powder according to any one of claim 3 to 6, is characterized in that, comprise the steps:
Get legume seeds, through the first pretreatment, first dry, the first pulverizing, obtain legume seeds powder;
Get fragrant plant, through the second pretreatment, second dry, the second pulverizing, obtain fragrant plant powder;
Get Rabdosia rubescens and ethanol water mixing, through alcohol extraction, obtain Rabdosia rubescens alcohol extract; Get described Rabdosia rubescens alcohol extract, remove ethanol, mix with beta-schardinger dextrin-, through rectification, drying, pulverizing, obtain beta-cyclodextrin inclusion compound Rabdosia rubescens powder;
Obtain marine organism extract, described marine organism extract is chitosan and/or chitin;
Get the mixing of described legume seeds powder, described fragrant plant powder, described beta-cyclodextrin inclusion compound Rabdosia rubescens powder and described marine organism extract, through the 3rd pulverizing, sieve, to obtain final product.
8. preparation method according to claim 7, is characterized in that, the described 3rd fineness pulverized is 100 ~ 325 orders.
9. treat a Diaper Dermatitis of Newborn medicine, it is characterized in that, it comprises anti-inflammation compositions as claimed in claim 1 and pharmaceutically acceptable adjuvant.
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| CN104606070A (en) * | 2014-12-31 | 2015-05-13 | 唯美度科技（北京）有限公司 | Dry and comfortable powder capable of removing miliaria and relieving itching |
| CN105919881A (en) * | 2016-06-11 | 2016-09-07 | 青蛙王子(中国)日化有限公司 | Pure natural baby powder ultramicro containing superfine tea tree pollen |
| CN108114029A (en) * | 2018-02-08 | 2018-06-05 | 陕西中医药大学 | A kind of active Chinese drug component compositions, its preparation method and its application |
| CN108888575A (en) * | 2018-08-09 | 2018-11-27 | 福建樱幼佳科技有限公司 | A kind of baby skin protection product and preparation method thereof |
| CN112603863B (en) * | 2020-12-21 | 2022-12-13 | 河南济世药业有限公司 | Rabdosia rubescens low-boiling-point volatile matter, extraction method and application thereof, and mosquito repelling product |
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Denomination of invention: Antibacterial and anti-inflammatory composition, talcum powder and preparation method thereof Effective date of registration: 20200828 Granted publication date: 20151125 Pledgee: Henan Jiyuan Rural Commercial Bank Co., Ltd Pledgor: HENAN JIYUAN JISHI PHARMACEUTICAL Co.,Ltd. Registration number: Y2020980005498 |
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Date of cancellation: 20210701 Granted publication date: 20151125 Pledgee: Henan Jiyuan Rural Commercial Bank Co., Ltd Pledgor: HENAN JIYUAN JISHI PHARMACEUTICAL Co.,Ltd. Registration number: Y2020980005498 |
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Address after: 454650 No.18 Chuangye Road, Yuquan characteristic industrial park, Jiyuan City, Henan Province Patentee after: Henan Jishi Pharmaceutical Co.,Ltd. Address before: 454650 Jiyuan Railway Station North Henan Jiyuan Jishi Pharmaceutical Co., Ltd Patentee before: HENAN JIYUAN JISHI PHARMACEUTICAL Co.,Ltd. |