CN101686956A - 用环糊精增加氟苯尼考及结构相关的抗生素的溶解度的化合物和方法 - Google Patents

用环糊精增加氟苯尼考及结构相关的抗生素的溶解度的化合物和方法 Download PDF

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Publication number
CN101686956A
CN101686956A CN200880021603A CN200880021603A CN101686956A CN 101686956 A CN101686956 A CN 101686956A CN 200880021603 A CN200880021603 A CN 200880021603A CN 200880021603 A CN200880021603 A CN 200880021603A CN 101686956 A CN101686956 A CN 101686956A
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China
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compositions
cyclodextrin
water
florfenicol
solvent
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Pending
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CN200880021603A
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English (en)
Chinese (zh)
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S·汤吉亚尼
K·A·弗里豪夫
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MSD International Holdings GmbH
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Schering Plough Ltd Switzerland
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Publication of CN101686956A publication Critical patent/CN101686956A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
    • C08B37/0015—Inclusion compounds, i.e. host-guest compounds, e.g. polyrotaxanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Nanotechnology (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Medical Informatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
CN200880021603A 2007-04-27 2008-04-23 用环糊精增加氟苯尼考及结构相关的抗生素的溶解度的化合物和方法 Pending CN101686956A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US91437607P 2007-04-27 2007-04-27
US60/914,376 2007-04-27
PCT/US2008/005225 WO2008133901A1 (en) 2007-04-27 2008-04-23 Compounds and methods for enhancing solubility of florfenicol and structurally-related antibiotics using cyclodextrins

Publications (1)

Publication Number Publication Date
CN101686956A true CN101686956A (zh) 2010-03-31

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CN200880021603A Pending CN101686956A (zh) 2007-04-27 2008-04-23 用环糊精增加氟苯尼考及结构相关的抗生素的溶解度的化合物和方法

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US (1) US20090062397A1 (enExample)
EP (1) EP2150245A1 (enExample)
JP (1) JP2010525059A (enExample)
KR (1) KR20100028537A (enExample)
CN (1) CN101686956A (enExample)
AR (1) AR066265A1 (enExample)
BR (1) BRPI0810601A2 (enExample)
CA (1) CA2685264A1 (enExample)
CL (1) CL2008001194A1 (enExample)
MX (1) MX2009011642A (enExample)
PE (1) PE20090234A1 (enExample)
RU (1) RU2009143731A (enExample)
TW (1) TW200908955A (enExample)
WO (1) WO2008133901A1 (enExample)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102160854A (zh) * 2011-04-15 2011-08-24 广东养宝生物制药有限公司 一种包合环糊精的氟苯尼考速释型水溶性粉末制剂及其制备方法
CN102688197A (zh) * 2012-06-07 2012-09-26 湖州爱宝莱动物药业有限公司 一种氟苯尼考水溶颗粒及其制备方法
CN104667291A (zh) * 2013-12-03 2015-06-03 中牧实业股份有限公司黄冈动物药品厂 一种改进的氟苯尼考包合物的制备方法
CN105055319A (zh) * 2015-07-22 2015-11-18 浙江大飞龙动物保健品有限公司 一种氟苯尼考可溶性粉及其制备方法
CN105079818A (zh) * 2015-08-31 2015-11-25 王玉万 用乙酰胺和环糊精制备氟苯尼考可溶性粉
CN105477642A (zh) * 2015-12-15 2016-04-13 中牧南京动物药业有限公司 一种高生物利用度的氟苯尼考组合物及其制备方法
CN110279664A (zh) * 2019-07-30 2019-09-27 四川农业大学 一种氟苯尼考包合物冻干粉针剂及其制备方法
CN111374949A (zh) * 2018-12-29 2020-07-07 西安市昌盛动物保健品有限公司 一种氟苯尼考可溶性粉或溶液的制备工艺
CN112716902A (zh) * 2021-02-04 2021-04-30 广州市和生堂动物药业有限公司 一种氟苯尼考粉及其制备方法
CN113230233A (zh) * 2021-05-14 2021-08-10 中国农业科学院兰州畜牧与兽药研究所 一种氟苯尼考固体分散包合微囊及其制备方法与应用
CN119385937A (zh) * 2024-11-20 2025-02-07 山东冉星动物药业有限公司 一种兽用氟苯尼考溶液及其制备方法和应用

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY146351A (en) 2003-05-29 2012-08-15 Schering Plough Ltd Compositions for treating infection in cattle and swine
CN101600686A (zh) * 2006-12-13 2009-12-09 先灵-普劳有限公司 氯霉素、甲砜霉素及其类似物的水溶性前药
GB2451811A (en) * 2007-08-09 2009-02-18 Ems Sa Delivery composition for solubilising water-insoluble pharmaceutical active ingredients
JP2011529895A (ja) * 2008-07-30 2011-12-15 インターベツト・インターナシヨナル・ベー・ベー フロルフェニコール中間体として有用なオキサゾリン保護アミノジオール化合物を調製する方法
JP5826473B2 (ja) * 2010-09-16 2015-12-02 協和発酵バイオ株式会社 直打用高単位グルコサミン顆粒
CN102813627A (zh) * 2012-09-19 2012-12-12 上海同仁药业有限公司 一种氟苯尼考可溶性粉剂的制备方法
CN104800167B (zh) * 2015-04-22 2018-04-10 河南牧翔动物药业有限公司 一种氟苯尼考可溶性粉及其制备方法
CN106177983A (zh) * 2016-08-03 2016-12-07 佛山科学技术学院 一种氟苯尼考‑β‑环糊精包合物及其制备方法
CN107519135A (zh) * 2017-09-30 2017-12-29 中牧实业股份有限公司黄冈动物药品厂 一种高水溶型氟苯尼考粉的制备方法
CN109602916A (zh) * 2018-12-13 2019-04-12 广东温氏大华农生物科技有限公司 一种氟苯尼考包合物及其制备方法
CN112535663A (zh) * 2019-09-23 2021-03-23 江西邦诚动物药业有限公司 一种速溶固体分散氟苯尼考粉及其制备方法
CN110787131B (zh) * 2019-12-13 2022-04-01 河北远征药业有限公司 一种氟苯尼考可溶性粉制剂的制备方法
CN112190551A (zh) * 2020-11-20 2021-01-08 湖北龙翔药业科技股份有限公司 一种氟苯尼考可溶性粉及其制备方法
CN112675315A (zh) * 2021-01-05 2021-04-20 佛山科学技术学院 一种γ-环糊精-替米考星包合物及其制备方法和应用
CN112641730A (zh) * 2021-02-19 2021-04-13 山东鲁抗舍里乐药业有限公司高新区分公司 一种可溶氟苯尼考粉的制备方法
CN114272213B (zh) * 2021-12-28 2023-10-10 厦门惠盈动物药业有限公司 一种氟苯尼考粉及其制备方法
CN114209656B (zh) * 2021-12-31 2023-08-01 浙江金朗博药业有限公司 一种氟苯尼考可溶性粉及其制备方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES488154A0 (es) * 1979-02-05 1981-04-16 Schering Corp Un procedimiento para la preparacion de un compuesto d-(treo-1-aril-2-acilamido-3-fluor-1-propanol
IT1173213B (it) * 1984-02-03 1987-06-18 Zambon Spa Procedimento per fluorurare alcuni derivati dall'1l-fenil-2-ammino-1,3-propandiolo e loro intermedi
US5105009A (en) * 1983-06-02 1992-04-14 Zambon S.P.A. Intermediates for the preparation of 1-(phenyl)-1-hydroxy-2-amino-3-fluoropropane derivatives
US5332835A (en) * 1984-02-03 1994-07-26 Zambon S.P.A. Process for fluorinating 1-phenyl-2-amino-1,3-propanediol compounds and new oxazoline compounds useful in this process
US4582918A (en) * 1984-09-19 1986-04-15 Schering Corporation Preparation of intermediates for (threo)-1-aryl-2-acylamido-3-fluoro-1-propanols
US4973750A (en) * 1984-09-19 1990-11-27 Schering Corporation Preparation of (threo)-1-aryl-2-acylamido-3-fluoro-1-propanols
US5227494A (en) * 1988-09-14 1993-07-13 Schering Corporation Process for preparing oxazoline compounds
US4876352A (en) * 1988-09-14 1989-10-24 Schering Corporation Pressurized fluorination of hydroxy alkyl groups
EP0443381B2 (en) * 1990-02-14 1997-10-22 Takeda Chemical Industries, Ltd. Effervescent composition, its production and use
NZ250394A (en) * 1990-10-25 1994-10-26 Schering Corp Fluorinated and hydroxylated oxazoline compounds
US5352832A (en) * 1992-12-18 1994-10-04 Schering Corporation Asymmetric process for preparing florfenicol, thiamphenicol chloramphenicol and oxazoline intermediates
US5663361A (en) * 1996-08-19 1997-09-02 Schering Corporation Process for preparing intermediates to florfenicol
GB0205253D0 (en) * 2002-03-06 2002-04-17 Univ Gent Immediate release pharmaceutical granule compositions and a continuous process for making them
US6790867B2 (en) * 2002-05-20 2004-09-14 Schering-Plough Animal Health Corporation Compositions and method for treating infection in cattle and swine
CN1459282A (zh) * 2003-05-29 2003-12-03 季华 水溶性氟苯尼考的生产方法

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102160854A (zh) * 2011-04-15 2011-08-24 广东养宝生物制药有限公司 一种包合环糊精的氟苯尼考速释型水溶性粉末制剂及其制备方法
CN102688197A (zh) * 2012-06-07 2012-09-26 湖州爱宝莱动物药业有限公司 一种氟苯尼考水溶颗粒及其制备方法
CN104667291A (zh) * 2013-12-03 2015-06-03 中牧实业股份有限公司黄冈动物药品厂 一种改进的氟苯尼考包合物的制备方法
CN105055319A (zh) * 2015-07-22 2015-11-18 浙江大飞龙动物保健品有限公司 一种氟苯尼考可溶性粉及其制备方法
CN105055319B (zh) * 2015-07-22 2018-04-10 浙江大飞龙动物保健品有限公司 一种氟苯尼考可溶性粉及其制备方法
CN105079818B (zh) * 2015-08-31 2018-04-20 王玉万 用乙酰胺和环糊精制备氟苯尼考可溶性粉
CN105079818A (zh) * 2015-08-31 2015-11-25 王玉万 用乙酰胺和环糊精制备氟苯尼考可溶性粉
CN105477642B (zh) * 2015-12-15 2019-08-06 中牧南京动物药业有限公司 一种高生物利用度的氟苯尼考组合物及其制备方法
CN105477642A (zh) * 2015-12-15 2016-04-13 中牧南京动物药业有限公司 一种高生物利用度的氟苯尼考组合物及其制备方法
CN111374949A (zh) * 2018-12-29 2020-07-07 西安市昌盛动物保健品有限公司 一种氟苯尼考可溶性粉或溶液的制备工艺
CN110279664A (zh) * 2019-07-30 2019-09-27 四川农业大学 一种氟苯尼考包合物冻干粉针剂及其制备方法
CN110279664B (zh) * 2019-07-30 2021-09-03 四川农业大学 一种氟苯尼考包合物冻干粉针剂及其制备方法
CN112716902A (zh) * 2021-02-04 2021-04-30 广州市和生堂动物药业有限公司 一种氟苯尼考粉及其制备方法
CN112716902B (zh) * 2021-02-04 2021-10-12 广州市和生堂动物药业有限公司 一种氟苯尼考粉及其制备方法
CN113230233A (zh) * 2021-05-14 2021-08-10 中国农业科学院兰州畜牧与兽药研究所 一种氟苯尼考固体分散包合微囊及其制备方法与应用
CN119385937A (zh) * 2024-11-20 2025-02-07 山东冉星动物药业有限公司 一种兽用氟苯尼考溶液及其制备方法和应用
CN119385937B (zh) * 2024-11-20 2025-07-15 山东金瑞生物科技有限公司 一种兽用氟苯尼考溶液及其制备方法和应用

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TW200908955A (en) 2009-03-01
MX2009011642A (es) 2010-01-29
WO2008133901A1 (en) 2008-11-06
JP2010525059A (ja) 2010-07-22
KR20100028537A (ko) 2010-03-12
US20090062397A1 (en) 2009-03-05
RU2009143731A (ru) 2011-06-10
EP2150245A1 (en) 2010-02-10
PE20090234A1 (es) 2009-04-02
CA2685264A1 (en) 2008-11-06
CL2008001194A1 (es) 2008-11-03
AR066265A1 (es) 2009-08-05
BRPI0810601A2 (pt) 2014-10-21

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