MX2009011642A - Compuestos y metodos para potenciar la solubilidad de florfenicol y antibioticos estructuralmente relacionados utilizando ciclodextrinas. - Google Patents
Compuestos y metodos para potenciar la solubilidad de florfenicol y antibioticos estructuralmente relacionados utilizando ciclodextrinas.Info
- Publication number
- MX2009011642A MX2009011642A MX2009011642A MX2009011642A MX2009011642A MX 2009011642 A MX2009011642 A MX 2009011642A MX 2009011642 A MX2009011642 A MX 2009011642A MX 2009011642 A MX2009011642 A MX 2009011642A MX 2009011642 A MX2009011642 A MX 2009011642A
- Authority
- MX
- Mexico
- Prior art keywords
- ffc
- florfenicol
- cyclodextrins
- structurally
- compounds
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
- A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
- C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
- C08B37/0015—Inclusion compounds, i.e. host-guest compounds, e.g. polyrotaxanes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Nanotechnology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Chemistry (AREA)
- Biophysics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Materials Engineering (AREA)
- Polymers & Plastics (AREA)
- Biochemistry (AREA)
- Medical Informatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
La solubilidad relativamente baja del florfenicol (FFC) en agua (1.3 mg/mI) limita su uso en sistemas medicados de agua potable para el tratamiento de enfermedades pulmonares de cerdos y aves de corral; las formulaciones actuales usan un solvente orgánico de alto volumen para alcanzar la concentración requerida de FFC de 13.5 mg/ml en un sistema de tanque mezclador proporcionador automatizado, con desventajas prácticas para los usuarios en el ramo; esta invención se refiere a los efectos de la formación compleja con ciclodextrinas naturales y modificadas en la solubilidad acuosa del FFC y antibióticos de estructura relacionada; además, esta invención se refiere a los efectos del poletilenglicol (PEG-300) como cosolvente en un sistema de FFC-ciclodextrina para lograr la dosis requerida de FFC en el sistema de tanque de mezclado y evitar altos volúmenes del solvente orgánico.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US91437607P | 2007-04-27 | 2007-04-27 | |
PCT/US2008/005225 WO2008133901A1 (en) | 2007-04-27 | 2008-04-23 | Compounds and methods for enhancing solubility of florfenicol and structurally-related antibiotics using cyclodextrins |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2009011642A true MX2009011642A (es) | 2010-01-29 |
Family
ID=39619330
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2009011642A MX2009011642A (es) | 2007-04-27 | 2008-04-23 | Compuestos y metodos para potenciar la solubilidad de florfenicol y antibioticos estructuralmente relacionados utilizando ciclodextrinas. |
Country Status (14)
Country | Link |
---|---|
US (1) | US20090062397A1 (es) |
EP (1) | EP2150245A1 (es) |
JP (1) | JP2010525059A (es) |
KR (1) | KR20100028537A (es) |
CN (1) | CN101686956A (es) |
AR (1) | AR066265A1 (es) |
BR (1) | BRPI0810601A2 (es) |
CA (1) | CA2685264A1 (es) |
CL (1) | CL2008001194A1 (es) |
MX (1) | MX2009011642A (es) |
PE (1) | PE20090234A1 (es) |
RU (1) | RU2009143731A (es) |
TW (1) | TW200908955A (es) |
WO (1) | WO2008133901A1 (es) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR044437A1 (es) * | 2003-05-29 | 2005-09-14 | Schering Plough Ltd | Composiciones y metodo para el tratamiento de infecciones en ganado vacuno y porcino |
EP2102154A1 (en) * | 2006-12-13 | 2009-09-23 | Schering-Plough Ltd. | Water-soluble prodrugs of chloramphenicol, thiamphenicol, and analogs thereof |
GB2451811A (en) * | 2007-08-09 | 2009-02-18 | Ems Sa | Delivery composition for solubilising water-insoluble pharmaceutical active ingredients |
CN102131772B (zh) * | 2008-07-30 | 2015-03-11 | 英特威国际有限公司 | 用作氟苯尼考的中间体的*唑啉-保护的氨基二醇化合物的制备方法 |
JP5826473B2 (ja) * | 2010-09-16 | 2015-12-02 | 協和発酵バイオ株式会社 | 直打用高単位グルコサミン顆粒 |
CN102160854A (zh) * | 2011-04-15 | 2011-08-24 | 广东养宝生物制药有限公司 | 一种包合环糊精的氟苯尼考速释型水溶性粉末制剂及其制备方法 |
CN102688197A (zh) * | 2012-06-07 | 2012-09-26 | 湖州爱宝莱动物药业有限公司 | 一种氟苯尼考水溶颗粒及其制备方法 |
CN102813627A (zh) * | 2012-09-19 | 2012-12-12 | 上海同仁药业有限公司 | 一种氟苯尼考可溶性粉剂的制备方法 |
CN104667291A (zh) * | 2013-12-03 | 2015-06-03 | 中牧实业股份有限公司黄冈动物药品厂 | 一种改进的氟苯尼考包合物的制备方法 |
CN104800167B (zh) * | 2015-04-22 | 2018-04-10 | 河南牧翔动物药业有限公司 | 一种氟苯尼考可溶性粉及其制备方法 |
CN105055319B (zh) * | 2015-07-22 | 2018-04-10 | 浙江大飞龙动物保健品有限公司 | 一种氟苯尼考可溶性粉及其制备方法 |
CN105079818B (zh) * | 2015-08-31 | 2018-04-20 | 王玉万 | 用乙酰胺和环糊精制备氟苯尼考可溶性粉 |
CN105477642B (zh) * | 2015-12-15 | 2019-08-06 | 中牧南京动物药业有限公司 | 一种高生物利用度的氟苯尼考组合物及其制备方法 |
CN106177983A (zh) * | 2016-08-03 | 2016-12-07 | 佛山科学技术学院 | 一种氟苯尼考‑β‑环糊精包合物及其制备方法 |
CN107519135A (zh) * | 2017-09-30 | 2017-12-29 | 中牧实业股份有限公司黄冈动物药品厂 | 一种高水溶型氟苯尼考粉的制备方法 |
CN109602916A (zh) * | 2018-12-13 | 2019-04-12 | 广东温氏大华农生物科技有限公司 | 一种氟苯尼考包合物及其制备方法 |
CN111374949A (zh) * | 2018-12-29 | 2020-07-07 | 西安市昌盛动物保健品有限公司 | 一种氟苯尼考可溶性粉或溶液的制备工艺 |
CN110279664B (zh) * | 2019-07-30 | 2021-09-03 | 四川农业大学 | 一种氟苯尼考包合物冻干粉针剂及其制备方法 |
CN112535663A (zh) * | 2019-09-23 | 2021-03-23 | 江西邦诚动物药业有限公司 | 一种速溶固体分散氟苯尼考粉及其制备方法 |
CN110787131B (zh) * | 2019-12-13 | 2022-04-01 | 河北远征药业有限公司 | 一种氟苯尼考可溶性粉制剂的制备方法 |
CN112190551A (zh) * | 2020-11-20 | 2021-01-08 | 湖北龙翔药业科技股份有限公司 | 一种氟苯尼考可溶性粉及其制备方法 |
CN112675315A (zh) * | 2021-01-05 | 2021-04-20 | 佛山科学技术学院 | 一种γ-环糊精-替米考星包合物及其制备方法和应用 |
CN112716902B (zh) * | 2021-02-04 | 2021-10-12 | 广州市和生堂动物药业有限公司 | 一种氟苯尼考粉及其制备方法 |
CN112641730A (zh) * | 2021-02-19 | 2021-04-13 | 山东鲁抗舍里乐药业有限公司高新区分公司 | 一种可溶氟苯尼考粉的制备方法 |
CN113230233A (zh) * | 2021-05-14 | 2021-08-10 | 中国农业科学院兰州畜牧与兽药研究所 | 一种氟苯尼考固体分散包合微囊及其制备方法与应用 |
CN114272213B (zh) * | 2021-12-28 | 2023-10-10 | 厦门惠盈动物药业有限公司 | 一种氟苯尼考粉及其制备方法 |
CN114209656B (zh) * | 2021-12-31 | 2023-08-01 | 浙江金朗博药业有限公司 | 一种氟苯尼考可溶性粉及其制备方法 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES8104203A1 (es) * | 1979-02-05 | 1981-04-16 | Schering Corp | Un procedimiento para la preparacion de un compuesto d-(treo-1-aril-2-acilamido-3-fluor-1-propanol |
IT1173213B (it) * | 1984-02-03 | 1987-06-18 | Zambon Spa | Procedimento per fluorurare alcuni derivati dall'1l-fenil-2-ammino-1,3-propandiolo e loro intermedi |
US5105009A (en) * | 1983-06-02 | 1992-04-14 | Zambon S.P.A. | Intermediates for the preparation of 1-(phenyl)-1-hydroxy-2-amino-3-fluoropropane derivatives |
US5332835A (en) * | 1984-02-03 | 1994-07-26 | Zambon S.P.A. | Process for fluorinating 1-phenyl-2-amino-1,3-propanediol compounds and new oxazoline compounds useful in this process |
US4973750A (en) * | 1984-09-19 | 1990-11-27 | Schering Corporation | Preparation of (threo)-1-aryl-2-acylamido-3-fluoro-1-propanols |
US4582918A (en) * | 1984-09-19 | 1986-04-15 | Schering Corporation | Preparation of intermediates for (threo)-1-aryl-2-acylamido-3-fluoro-1-propanols |
US4876352A (en) * | 1988-09-14 | 1989-10-24 | Schering Corporation | Pressurized fluorination of hydroxy alkyl groups |
US5227494A (en) * | 1988-09-14 | 1993-07-13 | Schering Corporation | Process for preparing oxazoline compounds |
ATE108649T1 (de) * | 1990-02-14 | 1994-08-15 | Takeda Chemical Industries Ltd | Brausemischung, deren herstellung sowie verwendung. |
ES2067958T3 (es) * | 1990-10-25 | 1995-04-01 | Schering Corp | Procedimiento para preparar florfenicol, sus analogos y productos intermedios de la oxazolina para dicho procedimiento. |
US5352832A (en) * | 1992-12-18 | 1994-10-04 | Schering Corporation | Asymmetric process for preparing florfenicol, thiamphenicol chloramphenicol and oxazoline intermediates |
US5663361A (en) * | 1996-08-19 | 1997-09-02 | Schering Corporation | Process for preparing intermediates to florfenicol |
GB0205253D0 (en) * | 2002-03-06 | 2002-04-17 | Univ Gent | Immediate release pharmaceutical granule compositions and a continuous process for making them |
US6790867B2 (en) * | 2002-05-20 | 2004-09-14 | Schering-Plough Animal Health Corporation | Compositions and method for treating infection in cattle and swine |
CN1459282A (zh) * | 2003-05-29 | 2003-12-03 | 季华 | 水溶性氟苯尼考的生产方法 |
-
2008
- 2008-04-23 MX MX2009011642A patent/MX2009011642A/es not_active Application Discontinuation
- 2008-04-23 EP EP08743209A patent/EP2150245A1/en not_active Withdrawn
- 2008-04-23 BR BRPI0810601-0A2A patent/BRPI0810601A2/pt not_active IP Right Cessation
- 2008-04-23 WO PCT/US2008/005225 patent/WO2008133901A1/en active Application Filing
- 2008-04-23 KR KR1020097024467A patent/KR20100028537A/ko not_active Application Discontinuation
- 2008-04-23 CA CA002685264A patent/CA2685264A1/en not_active Abandoned
- 2008-04-23 JP JP2010506241A patent/JP2010525059A/ja not_active Withdrawn
- 2008-04-23 CN CN200880021603A patent/CN101686956A/zh active Pending
- 2008-04-23 PE PE2008000695A patent/PE20090234A1/es not_active Application Discontinuation
- 2008-04-23 RU RU2009143731/15A patent/RU2009143731A/ru not_active Application Discontinuation
- 2008-04-23 US US12/108,032 patent/US20090062397A1/en not_active Abandoned
- 2008-04-23 AR ARP080101709A patent/AR066265A1/es unknown
- 2008-04-24 CL CL2008001194A patent/CL2008001194A1/es unknown
- 2008-04-24 TW TW097115132A patent/TW200908955A/zh unknown
Also Published As
Publication number | Publication date |
---|---|
RU2009143731A (ru) | 2011-06-10 |
CA2685264A1 (en) | 2008-11-06 |
TW200908955A (en) | 2009-03-01 |
BRPI0810601A2 (pt) | 2014-10-21 |
EP2150245A1 (en) | 2010-02-10 |
CN101686956A (zh) | 2010-03-31 |
KR20100028537A (ko) | 2010-03-12 |
JP2010525059A (ja) | 2010-07-22 |
US20090062397A1 (en) | 2009-03-05 |
CL2008001194A1 (es) | 2008-11-03 |
WO2008133901A1 (en) | 2008-11-06 |
AR066265A1 (es) | 2009-08-05 |
PE20090234A1 (es) | 2009-04-02 |
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Legal Events
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FA | Abandonment or withdrawal |