EA200401625A1 - Стабилизированные фармацевтические композиции на основе полиоксиэтилированного касторового масла и способ их получения - Google Patents

Стабилизированные фармацевтические композиции на основе полиоксиэтилированного касторового масла и способ их получения

Info

Publication number
EA200401625A1
EA200401625A1 EA200401625A EA200401625A EA200401625A1 EA 200401625 A1 EA200401625 A1 EA 200401625A1 EA 200401625 A EA200401625 A EA 200401625A EA 200401625 A EA200401625 A EA 200401625A EA 200401625 A1 EA200401625 A1 EA 200401625A1
Authority
EA
Eurasian Patent Office
Prior art keywords
producing
stabilized
polyoxyethylated
pharmaceutical compositions
compositions based
Prior art date
Application number
EA200401625A
Other languages
English (en)
Other versions
EA007223B1 (ru
Inventor
Владимир Кисилька
Либуше Затлоукалова
Борек Залудек
Карел Посписилик
Мария Циганкова
Мартин Кубат
Алес Цирква
Original Assignee
Плива-Лахема А. С.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Плива-Лахема А. С. filed Critical Плива-Лахема А. С.
Publication of EA200401625A1 publication Critical patent/EA200401625A1/ru
Publication of EA007223B1 publication Critical patent/EA007223B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Изобретение относится к стабилизированной фармацевтической композиции, содержащей фармацевтически приемлемое вещество, плохо растворимое в воде, солюбилизирующий агент с низким содержанием как основных, так и кислых соединений и полярный органический растворитель, в особенности, относится к стабилизированному концентрату для инъекций, способам получения указанных стабилизированных композиций и применению солюбилизирующего агента с низким содержанием как основных, так и кислых соединений для стабилизации фармацевтических композиций фармацевтически активных веществ.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200401625A 2002-06-10 2003-05-16 Стабилизированные фармацевтические композиции на основе полиоксиэтилированного касторового масла и способ их получения EA007223B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CZ20022027A CZ294371B6 (cs) 2002-06-10 2002-06-10 Stabilizovaná farmaceutická kompozice na bázi polyoxyethylovaného ricinového oleje a způsob její přípravy
PCT/EP2003/005153 WO2003103714A1 (en) 2002-06-10 2003-05-16 Stabilised pharmaceutical compositions on the basis of polyoxyethylated castor oil and method for manufacturing the same

Publications (2)

Publication Number Publication Date
EA200401625A1 true EA200401625A1 (ru) 2005-06-30
EA007223B1 EA007223B1 (ru) 2006-08-25

Family

ID=29721409

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200401625A EA007223B1 (ru) 2002-06-10 2003-05-16 Стабилизированные фармацевтические композиции на основе полиоксиэтилированного касторового масла и способ их получения

Country Status (19)

Country Link
US (1) US20050142225A1 (ru)
EP (1) EP1515751A1 (ru)
JP (1) JP2005534656A (ru)
KR (1) KR20050010030A (ru)
CN (1) CN1655824A (ru)
AU (1) AU2003240661A1 (ru)
BR (1) BR0311687A (ru)
CA (1) CA2487889A1 (ru)
CZ (1) CZ294371B6 (ru)
EA (1) EA007223B1 (ru)
HR (1) HRP20041107A2 (ru)
IL (2) IL165027A0 (ru)
IS (1) IS7551A (ru)
MX (1) MXPA04011990A (ru)
NZ (1) NZ537150A (ru)
PL (1) PL372071A1 (ru)
RS (1) RS106704A (ru)
WO (1) WO2003103714A1 (ru)
ZA (1) ZA200408892B (ru)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007532629A (ja) 2004-04-15 2007-11-15 キアスマ， インコーポレイテッド 生物学的障壁を横切る透過を促進し得る組成物
GT200500310A (es) * 2004-11-19 2006-06-19 Compuestos organicos
AU2006212177A1 (en) * 2005-02-10 2006-08-17 Sindan Pharma Srl Method of purifying a surfactant by ultrafiltration
EP1690551A3 (en) * 2005-02-10 2006-10-18 Sindan Pharma Srl Method of purifying a surfactant by ultrafiltration
SA06270147B1 (ar) 2005-06-09 2009-12-22 نوفارتيس ايه جي عملية لتخليق 5-(مثيل–1h–إيميدازول–1-يل )–3-(ثلاثي فلـورو مثيل)–بنزامـين
DE102007055341A1 (de) * 2007-11-19 2009-05-20 Bayer Animal Health Gmbh Stabilisierung öliger Suspensionen enthaltend hydrophobe Kieselsäuren
DE102008011691A1 (de) * 2008-02-28 2009-09-10 Schülke & Mayr GmbH Stabilisierte, antimikrobiell wirksame Zusammensetzung mit einem Gehalt an Bispyridiniumalkan
CN101596159B (zh) * 2008-06-03 2012-12-19 哈药集团生物工程有限公司 一种紫杉醇注射液及其制备方法
KR101814186B1 (ko) 2008-09-17 2018-03-14 키아스마 인코포레이티드 약제학적 조성물 및 연관된 투여방법
CN102223875A (zh) * 2008-11-21 2011-10-19 贝林格尔.英格海姆国际有限公司 口服给药的强效hcv抑制剂的药物组合物
MA33491B1 (fr) 2009-07-07 2012-08-01 Boehringer Ingelheim Int Composition pharmaceutique pour un inhibiteur de protease virale de l'hépatite c
CN101829051B (zh) * 2010-05-31 2012-09-12 南昌弘益科技有限公司 1’-乙酰氧基胡椒酚乙酸酯注射液
US10238709B2 (en) 2015-02-03 2019-03-26 Chiasma, Inc. Method of treating diseases
CN105497905A (zh) * 2015-12-30 2016-04-20 钟术光 一种供注射或口服用的辅料
US11141457B1 (en) 2020-12-28 2021-10-12 Amryt Endo, Inc. Oral octreotide therapy and contraceptive methods
CN112778513A (zh) * 2020-12-30 2021-05-11 江苏优仿医药科技有限公司 一种聚氧乙烯蓖麻油的精制方法及其应用
CN113281425B (zh) * 2021-04-15 2023-06-06 四川汇宇制药股份有限公司 一种聚氧乙烯(35)蓖麻油中游离脂肪酸的检测方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55108823A (en) * 1979-02-13 1980-08-21 Takemoto Oil & Fat Co Ltd Purification of alkylene oxide addition compound
US5112750A (en) * 1985-06-25 1992-05-12 Asama Chemical Co., Ltd. Immobilized cells and culture method utilizing the same
JPH02157274A (ja) * 1988-12-07 1990-06-18 Sumitomo Heavy Ind Ltd 植物油からビタミンｅを分離濃縮する方法
US6150398A (en) * 1991-05-08 2000-11-21 The United States Of America As Represented By The Department Of Health And Human Services Methods for the treatment of cancer
CA2086874E (en) * 1992-08-03 2000-01-04 Renzo Mauro Canetta Methods for administration of taxol
AU680441B2 (en) * 1992-09-22 1997-07-31 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Use of taxol for treating lymphomas and breast cancer
EP0674510B1 (en) * 1992-11-27 1998-08-05 Napro Biotherapeutics, Inc. Injectable composition comprising paclitaxel
NZ258044A (en) * 1992-11-27 1995-12-21 Faulding F H & Co Ltd Pharmaceutical composition comprising taxol, solubilising agent, an acid and an organic solvent
CA2092271C (en) * 1993-03-09 2009-10-13 Eddie Reed Use of g-csf for treating taxol side-effects
ATE339975T1 (de) * 1993-07-19 2006-10-15 Angiotech Pharm Inc Anti-angiogener stent und verfahren zu dessen herstellung
TW406020B (en) * 1993-09-29 2000-09-21 Bristol Myers Squibb Co Stabilized pharmaceutical composition and its method for preparation and stabilizing solvent
ATE201962T1 (de) * 1995-04-28 2001-06-15 Loders Croklaan Bv An polyungesättigten fettsäuren reiche triglyceride
DE19536165A1 (de) * 1995-09-28 1997-04-03 Basf Ag Verfahren zur Reinigung von alkoxylierten Fetten
US5925776A (en) * 1997-12-24 1999-07-20 Schein Pharmacetical, Inc. Polyethoxylated castor oil, process of making the same and formulations thereof
JP2000044840A (ja) * 1998-07-28 2000-02-15 Mitsubishi Heavy Ind Ltd 燃料ガス漏洩検知塗膜
US6388112B1 (en) * 1998-10-20 2002-05-14 Ben Venue Laboratories, Inc. Process for purification of solvents useful in the preparation of pharmaceutical compositions
JP4697569B2 (ja) * 1999-09-22 2011-06-08 日本アエロジル株式会社 表面改質シリカ微粉末とその用途
JP2001247847A (ja) * 2000-03-03 2001-09-14 Nisshin Oil Mills Ltd:The 水性ゲル化剤
US7115565B2 (en) * 2001-01-18 2006-10-03 Pharmacia & Upjohn Company Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability

Also Published As

Publication number Publication date
MXPA04011990A (es) 2005-08-16
BR0311687A (pt) 2008-01-15
AU2003240661A1 (en) 2003-12-22
KR20050010030A (ko) 2005-01-26
IL165027A (en) 2009-12-24
US20050142225A1 (en) 2005-06-30
CA2487889A1 (en) 2003-12-18
IL165027A0 (en) 2005-12-18
JP2005534656A (ja) 2005-11-17
EA007223B1 (ru) 2006-08-25
EP1515751A1 (en) 2005-03-23
RS106704A (en) 2006-12-15
CN1655824A (zh) 2005-08-17
HRP20041107A2 (en) 2005-02-28
CZ294371B6 (cs) 2004-12-15
CZ20022027A3 (cs) 2004-01-14
WO2003103714A1 (en) 2003-12-18
IS7551A (is) 2004-11-25
PL372071A1 (en) 2005-07-11
NZ537150A (en) 2006-09-29
ZA200408892B (en) 2006-01-25

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Legal Events

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU