CN101684435B - Sterilization hand washing solution - Google Patents

Sterilization hand washing solution Download PDF

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Publication number
CN101684435B
CN101684435B CN 200810168473 CN200810168473A CN101684435B CN 101684435 B CN101684435 B CN 101684435B CN 200810168473 CN200810168473 CN 200810168473 CN 200810168473 A CN200810168473 A CN 200810168473A CN 101684435 B CN101684435 B CN 101684435B
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hand cleanser
disinfection hand
alkyl
cationic germicide
peg
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CN101684435A (en
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张富山
蔡增雄
罗梅芳
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QUANZHOU JINJIANG HENGAN HEALTH SCIENCE & TECHNOLOGY CO., LTD.
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Heng'an Anti-Bacteria Science & Tech Development Co Ltd Jinjiang
HENG'AN LIRENTANG (JI'AN) DAILY CHEMICAL CO Ltd
Hengan Fujian Holding Group Co Ltd
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Abstract

The invention relates to a sterilization hand washing solution, comprising the following ingredients in percentage by weight: 0.05-10 cationic bactericide, 0.1-5 thickening agent, 1-50 amphoteric surfactant, at least one surfactant of nonionic surfactant and cationic surfactant, and deionized water. The sterilization hand washing solution provided by the invention not only has the properties of detergency and foaminess but also has bactericidal performance, thereby bringing convenient, safe and effective sterilization effect for personal cleaning and nursing.

Description

A kind of disinfection hand cleanser
Technical field
The present invention relates to a kind of Liquid soap, especially relate to a kind of have good sterilization, the disinfection hand cleanser of dirt-removing functions.
Background technology
People are in life and work, and both hands unavoidably can contact and have microorganism, even the article of pathogenic microorganism, thereby make the both hands bacterial infection.The measure of protecting from infection, first-selection are the article of avoiding contact stain to cross, secondly are will form good Personal hygiene custom to accomplish that duty washes one's hands, and the probability of propagating because of the hand contact is stopped in diligent sterilization.At present, Liquid soap is accepted by increasing human consumer as a kind of daily articles for washing, and has entered into huge numbers of families.And at present the kind of washing composition is also multifarious, and various is that the product of the washing composition class of main raw material arises at the historic moment with dodecyl alcohol sodium sulfate, ammonium alkyl sulfate, dodecyl polyoxyethylene sodium sulfate, sodium-chlor, essence and pigment and water etc.Some Liquid soap adopts the composite of cationic germicide and anion surfactant in the prior art, as publication number is the Chinese patent of CN1104423A, relate to sterilization-disinfecting detergent composition, comprise cationic germicide, metal chelator and at least a anion surfactant that is selected from, the tensio-active agent of nonionogenic tenside and amphoterics.General has a broad antifungal spectrum of cationic germicide and instant effect, yet when the electronegative material of cationic germicide and other such as protein contact, cationic germicide and anionic species form title complex easily reduces detergency, and has had a strong impact on the germicidal action of cationic germicide.
The most of product functions of Liquid soap of the prior art are single, detersive power is strong, cost is higher or sterilization is strong etc., and some product life-time service also has injury to people's skin.
Summary of the invention
The purpose of this invention is to provide a kind of the have good sterilization and the Liquid soap of dirt-removing functions.
The purpose of this invention is to provide a kind of disinfection hand cleanser, this Liquid soap does not contain anion surfactant, and has good detergency and bactericidal properties.
According to Liquid soap provided by the invention, it mainly comprises:
(a) 0.05-10wt% cationic germicide, described cationic germicide are selected from quaternary ammonium salt such as methylbenzethonium chloride, benzalkonium chloride, phenmethyl alkyl ammomium chloride, cetylpyridinium chloride, dialkyl monohalide Dimethyl Ammonium, halogenation monoalkylated benzenes methyl alkyl ammonium chloride; At least a in biguanides such as glyconic acid Tubulicid, acetate Tubulicid, chlorhexidine hydrochloride, the polyhexamethylene guanidine;
(b) thickening material of 0.1-5wt%;
(c) at least a tensio-active agent in the amphoterics of 1-50wt%, nonionogenic tenside and the cats product;
(d) deionized water.
Compare with traditional Liquid soap, disinfection hand cleanser composition of the present invention is also unique bactericidal properties except possessing its this detergency that has and foaminess.Wherein the composite use of amphoterics or amphoterics, nonionogenic tenside and/or cats product provides detergency, has good cleaning effect; Cationic germicide provides fast, high-caliber anti-microbial activity, fabulous germicidal action.For personal cleanliness's nursing brings convenient, safe and effective sterilization effect.
The component (a) of disinfection hand cleanser composition of the present invention is described below, (b) and (c).
The consumption of component (a) sterilant accounts for the 0.05-10wt% of total amount, the content of described component (a) sterilant is preferably 0.05-8wt%, the content of described component (a) sterilant is 0.1-7wt% more preferably, and the content of described component (a) sterilant is preferably 0.5-2wt% especially.
The example that is used for component of the present invention (b) thickening material comprises alkylolamide class such as cocounut oil diglycollic amide, coconut monoethanol amide, cocounut oil list isopropanol amide, coconut oleoyl amine, lauroyl-LADEA, lauroyl-myristoyl diglycollic amide, different stearic diglycollic amide, inferior oily diglycollic amide, the cardamom diglycollic amide, the cardamom single ethanol amide, the oil diglycollic amide, the palm single ethanol amide, the Viscotrol C single ethanol amide, the sesame diglycollic amide, the soybean diglycollic amide, stearic diglycollic amide, stearic single ethanol amide, stearic single ethanol amide stearate, stearylamide, the tallow single ethanol amide, the wheatgerm diglycollic amide, PEG (polyoxyethylene glycol)-3 laurylamide, the PEG-4 oleylamide, PEG-50 tallow acid amides etc.; Natural gum and modifier thereof such as Lalgine and (ammonium, calcium, potassium) salt thereof, pectin, hyaluronate sodium, guar gum, cation guar gum, hydroxypropylguar gum, tragacanth gum, carrageeman and (calcium, sodium) salt thereof, xanthan gum, microsolerotium glue etc.; Ester class such as PEG-80 glyceryl butter ester, PEC-8-PPG (polypropylene glycol)-3 diisopstearate, PEG-200 hydrogenating glycerol base cetylate, PEG-n (n=6,8,12) beeswax, the PEG-4 isostearate, PEG-n (n=3,4,8,150,6000) SUNSOFT Q-182S, PEG-18 glyceryl oleic acid ester/cocounut oil acid esters, the PEG-8 dioleate, PEG-200 glyceryl stearate, PEG-n (n=28,200) glyceryl butter ester, the PEG-7 hydrogenated castor oil, the PEG-40 Jojoba oil, the PEG-2 laurate, PEG-120 methyl glucoside dioleate, PEG-150 season penta tetrastearate, PEG-55 propylene glycol oleic acid ester, PEG-160 sorbitanic three isostearates, PEG-n (n=8,75,100) stearate, PEG-150/ decyl/SMDI multipolymer (polyoxyethylene glycol-150/ decyl/alkylmethacrylate polymer), PEG-150/ stearyl/SMDI multipolymer, PEG-90.Isostearate, PEG-8-PPG-3 dilaurate, spermaceti cardamom ester, spermaceti palm ester, season penta tetrastearate, Ji Wusi behenate, propylene glycol stearate, behenate, cetyl, three Glyceryl Behenates, trihydroxy-stearin etc.; And cellulose family such as carboxymethyl hydroxyethyl cellulose, spermaceti Natvosol, Natvosol, hydroxypropylcellulose, hydroxypropyl methyl fiber etc.Special preferred cellulose class thickening material.Can use one or more thickening materials, thickening material content in Liquid soap is preferably 0.1-5wt%, and more preferably 0.15-4wt% is preferably 0.2-3wt% especially.
Component of the present invention (c) is at least a tensio-active agent in amphoterics, nonionogenic tenside and the cats product.The consumption of tensio-active agent accounts for the 1-50wt% of Liquid soap total amount.Be preferably 1.5-40wt%, more preferably 2-30wt% is preferably 3-20wt% especially.Amphoterics can be at least a in alkylamide propyl-betaine, alkyl hydroxy sultaine, amide group amino acid, alkyl both sexes sodium-acetate, the p dialkylaminobenzoic acid salt, and this tensio-active agent preferably contains 8-18 carbon atom.Nonionogenic tenside can be at least a in Voranol EP 2001, Vykamol Sorbitol 8B, Polyoxyethylene Sorbitol Fatty Acid Esters, alkyl glycoside, glyceryl ester and the aliphatic amide, and this tensio-active agent preferably contains 8-18 carbon atom.Cats product can be in alkyl dimethyl amine oxide, alkylamide propyl amine oxide, the polyquaternary amine salt at least a, this tensio-active agent is preferably and contains 8-18 carbon atom.
In the disinfection hand cleanser composition of the present invention, consider the pungency of cationic germicide, can add the irritation thing, the irritation thing can be at least a in plant sterol or the aloe powder.
Can add some agent of water-soluble tax fat or water-soluble silicon oils, play the skin care effect.Can use one or more to compose the fat agent.Compose fat agent content in Liquid soap and be preferably 0.1-10wt%, more preferably 0.2-7wt% is preferably 0.2-5wt% especially.
In the disinfection hand cleanser of the present invention, can also add some metal chelators, metal chelator can promote the germicidal action of disinfection hand cleanser.This metal chelator does not have particular requirement, selects the most frequently used ethylenediamine tetraacetic acid (EDTA) (EDTA) in the disinfection hand cleanser composition of the present invention for use.
In the disinfection hand cleanser composition of the present invention, can also add some wetting Agent for Printing Inkss.Examples of humectants comprises glycerine, propylene glycol, sorbyl alcohol, diethylene glycol monoethyl ether, panthenol, hydroxyethyl urea element, citric acid glyceride and is the conditioning wetting agent of describing in the Chinese patent of CN1120851A at publication number, wherein most preferably glycerine and propylene glycol.
The above any material that adds only otherwise influence sterilization effect of the present invention can add.Further specify the efficient sterilizing effect and the gentle skin care effect of disinfection hand cleanser composition of the present invention by following examples.The actives composition of each component is and very is the basis among the embodiment, and its consumption is represented with " wt% " all by weight percentage.
The disinfection hand cleanser composition for preparing embodiment 1-embodiment 10 by following method: at ambient temperature, earlier with part deionized water dissolving high molecular polymer, after treating that the high molecular polymer swelling fully, add tensio-active agent, sterilant, antiseptic-germicide, water and essence etc. more successively, regulate pH value with citric acid more at last, the pH value scope is about 6-7.
Carry out bactericidal assay by following method, measure its fungicidal effectiveness.
Test organisms
Bacterium: intestinal bacteria (8099 or ATCC25922), streptococcus aureus (ATCC6538); Yeast: Candida albicans (ATCC10231).
Medium preparation
According to the different different substratum of microbial strains preparation.Nutrient agar: after getting a certain amount of peptone, extractum carnis, sodium-chlor and distilled water mixed dissolution, transfer pH to 7.2~7.4, add agar, heating for dissolving is cultivated usefulness in 121 ℃ of pressuresteam sterilization 20min for intestinal bacteria, streptococcus aureus.Sabouraud's agar: after getting a certain amount of glucose, peptone, agar and distilled water mixing, be heated to dissolving fully, transfer pH to 5.6 ± 0.2,, cultivate usefulness for Candida albicans in 115 ℃ of pressuresteam sterilization 30min.
The bacteria suspension preparation
Get test organisms 24h slant culture and wash with 5mL0.03mol/L phosphate buffered saline buffer (hereinafter to be referred as PBS), be diluted to desired concn with above-mentioned PBS, (concentration of requirement is: drip in 5mL sample liquid with 100 μ L, reclaiming the bacterium number is 1 * 10 to make bacteria suspension 4~9 * 10 4Cfu/mL).
Bactericidal assay
Get by test liquid (5mL) with to each 4 pipe of liquid in the same old way (with the sample homogeneous material, equal size, but do not contain anti-biotic material, and) through sterilising treatment.Get above-mentioned bacteria suspension, respectively at each by test liquid with to dripping 100 μ L in the liquid in the same old way, mix with motorized agitator, pick up counting, effect 2,5,10,20min contains the corresponding neutralizing agent of 5mL in vitro with sample liquid (0.5mL) input respectively, fully mixing, do suitably dilution, get wherein 2~3 extent of dilution then, draw 0.5mL respectively, place two plates, nutrient agar (bacterium) or sabouraud's agar (yeast) 15mL with cold to 40~45 ℃ pour into, rotate plate, make it full and uniform, it is dull and stereotyped that agar solidifies the back upset, cultivate 48h (bacterium) or 72h (yeast), do the viable bacteria enumeration for 35 ℃ ± 2 ℃.Test repeats 3 times, averages.
Fungicidal effectiveness is judged
After cultivating 48h or 72h, calculate bacteriostasis rate: X=(A-B)/A * 100% as follows.In the formula: X is a bacteriostasis rate, and A is the average colony number of control sample, and B is tested sample average colony number.Judgement criteria: sterilizing rate 〉=90%, product has germicidal action.
The bactericidal assay method that utilization is above, respectively present embodiment 1-embodiment 10 is carried out bactericidal assay, at last the per-cent with the starting point concentration of the microorganism concn of not survival and microorganism is basis for estimation, judges the fungicidal effectiveness of disinfection hand cleanser composition of the present invention.
Embodiment 1
Get the cationic germicide of 0wt%, the two stearates of 2wt%PEG-6000, the 10wt% AMONYL 380LC, 6wt% cocamidopropyl propyl amide hydroxyl sulfo betaine, 2wt% cocounut oil acyl both sexes guanidine-acetic acid sodium, 4wt% fatty alcohol-polyoxyethylene ether, the 4wt% alkyl glycoside, 2wt% polyquaternary amine salt, 10wt% glycerine, 2wt% propylene glycol.The sterilizing rate of the Liquid soap that provides according to present embodiment is 0.
Embodiment 2
Get the cationic germicide of 0wt%, the antiseptic-germicide of 0.3wt% triclosan, the two stearates of 2wt%PEG-6000, the 10wt% AMONYL 380LC, 6wt% cocamidopropyl propyl amide hydroxyl sulfo betaine, 2wt% cocounut oil acyl both sexes guanidine-acetic acid sodium, the 4wt% alkyl glycoside, the 2wt% dimethyl dodecyl amine oxide, 10wt% glycerine, 2wt% propylene glycol.The sterilizing rate of the Liquid soap that provides according to present embodiment is 33%.
Embodiment 3
Get cationic germicide, the 1wt% Natvosol of 0.1wt% chlorhexidine hydrochloride, the 1wt% Vltra tears, the 10wt% AMONYL 380LC, 6wt% cocamidopropyl propyl amide hydroxyl sulfo betaine, 2wt% cocounut oil acyl both sexes guanidine-acetic acid sodium, 4wt% fatty alcohol-polyoxyethylene ether, 1wt% polyquaternary amine salt, the 1wt% dimethyl dodecyl amine oxide, 10wt% glycerine, 2wt% propylene glycol.The sterilizing rate of the Liquid soap that provides according to present embodiment is 99%.
Embodiment 4
Get cationic germicide, the 2wt% Natvosol of 0.2wt% polyhexamethylene guanidine, the 10wt% AMONYL 380LC, 6wt% cocamidopropyl propyl amide hydroxyl sulfo betaine, 2wt% cocounut oil acyl both sexes guanidine-acetic acid sodium, the 4wt% fatty alcohol-polyoxyethylene ether, 4wt% alkyl glycoside, 2wt% polyquaternary amine salt, 10wt% glycerine, the 2wt% propylene glycol.The sterilizing rate of the Liquid soap that provides according to present embodiment is 99%.
Embodiment 5
Get the cationic germicide of 0.1wt% phenmethyl alkyl ammomium chloride, the 2wt% Vltra tears, the 10wt% AMONYL 380LC, 6wt% cocamidopropyl propyl amide hydroxyl sulfo betaine, 2wt% cocounut oil acyl both sexes guanidine-acetic acid sodium, 4wt% fatty alcohol-polyoxyethylene ether, the 4wt% alkyl glycoside, the 2wt% dimethyl dodecyl amine oxide, 10wt% glycerine, 2wt% propylene glycol.The sterilizing rate of the Liquid soap that provides according to present embodiment is 99%.
Embodiment 6
Get the cationic germicide of 0.1wt% polyhexamethylene guanidine and 0.1wt% methylbenzethonium chloride, the 1wt% Natvosol, the 1wt% Vltra tears, 10wt% AMONYL 380LC, 6wt% coconut oleoyl amine hydroxyl sulfo betaine, 2wt% cocounut oil acyl both sexes guanidine-acetic acid sodium, the 4wt% fatty alcohol-polyoxyethylene ether, 1wt% polyquaternary amine salt, 1wt% dimethyl dodecyl amine oxide, 10wt% glycerine, the 2wt% propylene glycol.The sterilizing rate of the Liquid soap that provides according to present embodiment is 99%.
Embodiment 7
Get 0.1wt% chlorhexidine hydrochloride, 0.1wt% polyhexamethylene guanidine, 1wt% Natvosol, the two stearates of 1wt%PEG-6000, the 10wt% AMONYL 380LC, 6wt% coconut oleoyl amine hydroxyl sulfo betaine, 2wt% cocounut oil acyl both sexes guanidine-acetic acid sodium, the 4wt% fatty alcohol-polyoxyethylene ether, the 4wt% alkyl glycoside, 1.5wt% polyquaternary amine salt, 0.5wt% dimethyl dodecyl amine oxide, 10wt% glycerine, the 2wt% propylene glycol.The sterilizing rate of the Liquid soap that provides according to present embodiment is 99%.
The fungicidal effectiveness of the Liquid soap of embodiment 1-embodiment 7 is as shown in the table,
Mixture To intestinal bacteria effects (%) To streptococcus aureus effect (%) To Candida albicans effect (%)
Embodiment 1 Invalid Invalid Invalid
Embodiment 2 Invalid Invalid Invalid
Embodiment 3-embodiment 7 Effectively Effectively Effectively
Show from table 1 result: the Liquid soap that embodiment 1 provides does not have sterilant, and fungicidal effectiveness is 0; As sterilant, fungicidal effectiveness is very low with triclosan for the Liquid soap that embodiment 2 provides, and does not have a germicidal action; The Liquid soap mixture fungicidal effectiveness that embodiment 3-embodiment 7 provides is fine, has stronger germicidal action.
Though reference several preferred implementations wherein show the present invention and describe, but above-mentioned only is several embodiment of the present invention, but design concept of the present invention is not limited thereto, and can carry out various changes, deletion and increase to its form and details without departing from the spirit and scope of the present invention.But should be noted that some possible modification still fall in the protection domain of claim.

Claims (6)

1. disinfection hand cleanser, it comprises:
(a) cationic germicide of 0.05-10wt%, wherein said cationic germicide are selected from least a in glyconic acid Tubulicid, acetate Tubulicid, chlorhexidine hydrochloride, the polyhexamethylene guanidine;
(b) thickening material of 0.1-5wt%, wherein said thickening material are selected from least a in carboxymethyl hydroxyethyl cellulose, Natvosol, spermaceti Natvosol, hydroxypropylcellulose, the Vltra tears;
(c) at least a tensio-active agent in the amphoterics of 1-50wt%, nonionogenic tenside and the cats product;
(d) at least a irritation thing in plant sterol, the aloe powder;
(e) deionized water;
Wherein, described amphoterics is selected from least a in alkylamide propyl-betaine, alkyl hydroxy sultaine, amide group amino acid, alkyl both sexes sodium-acetate, the p dialkylaminobenzoic acid salt; Described nonionogenic tenside is selected from least a in alkyl glycoside, the fatty alcohol-polyoxyethylene ether; Described cats product is selected from least a in alkyl dimethyl amine oxide, alkylamide propyl amine oxide, the polyquaternium.
2. disinfection hand cleanser as claimed in claim 1, the content that it is characterized in that described cationic germicide is 0.05-8wt%.
3. disinfection hand cleanser as claimed in claim 2, the content that it is characterized in that described cationic germicide is 0.1-7wt%.
4. as each described disinfection hand cleanser of claim 1-3, it is characterized in that this disinfection hand cleanser also comprises at least a wetting Agent for Printing Inks in glycerine, propylene glycol, sorbyl alcohol, diethylene glycol monoethyl ether, panthenol, hydroxyethyl urea element, the citric acid glyceride.
5. as each described disinfection hand cleanser of claim 1-3, it is characterized in that this disinfection hand cleanser also comprises the ethylenediamine tetraacetic acid (EDTA) metal chelator.
6. as each described disinfection hand cleanser of claim 1-3, it is characterized in that this disinfection hand cleanser also comprises agent of water-soluble tax fat or water-soluble silicon oil.
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CN111803429A (en) * 2020-08-11 2020-10-23 齐鲁工业大学 Plant type no-clean hand sanitizer for children and preparation method
CN112315826A (en) * 2020-11-17 2021-02-05 江南大学 Functionalized graphene quantum dot antibacterial hand sanitizer and preparation method thereof
CN113150879A (en) * 2021-03-23 2021-07-23 广州市爱家有方日用品有限公司 Thickening composition for washing effervescent tablets and washing effervescent tablets
CN113521042A (en) * 2021-06-28 2021-10-22 青岛童医生海洋生物科技股份有限公司 Alcohol-free wash-free virus inactivation disinfectant special for children and preparation method thereof
CN114958491A (en) * 2022-06-22 2022-08-30 浙江工业大学 Detergent with antibacterial effect

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CN1246889A (en) * 1996-12-31 2000-03-08 雷克特和科尔曼产品有限公司 Abrasive cleaning compositions
CN1272132A (en) * 1997-09-30 2000-11-01 雷克特本克斯尔公司 Acidic, thickened and disinfecting compositions

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