CN111803429A - Plant type no-clean hand sanitizer for children and preparation method - Google Patents
Plant type no-clean hand sanitizer for children and preparation method Download PDFInfo
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- CN111803429A CN111803429A CN202010802382.5A CN202010802382A CN111803429A CN 111803429 A CN111803429 A CN 111803429A CN 202010802382 A CN202010802382 A CN 202010802382A CN 111803429 A CN111803429 A CN 111803429A
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- hand sanitizer
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- 238000002360 preparation method Methods 0.000 title abstract description 19
- 239000003921 oil Substances 0.000 claims abstract description 60
- 150000008442 polyphenolic compounds Chemical class 0.000 claims abstract description 49
- 235000013824 polyphenols Nutrition 0.000 claims abstract description 49
- 229940069521 aloe extract Drugs 0.000 claims abstract description 31
- 235000005979 Citrus limon Nutrition 0.000 claims abstract description 25
- 244000131522 Citrus pyriformis Species 0.000 claims abstract description 25
- 229960000686 benzalkonium chloride Drugs 0.000 claims abstract description 22
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims abstract description 22
- 241000196324 Embryophyta Species 0.000 claims abstract description 20
- 239000000341 volatile oil Substances 0.000 claims abstract description 14
- 239000000284 extract Substances 0.000 claims abstract description 11
- 239000001198 melaleuca alternifolia leaf oil Substances 0.000 claims abstract description 11
- 235000009024 Ceanothus sanguineus Nutrition 0.000 claims abstract description 5
- 235000015459 Lycium barbarum Nutrition 0.000 claims abstract description 5
- 241000366182 Melaleuca alternifolia Species 0.000 claims abstract description 5
- 239000000203 mixture Substances 0.000 claims abstract description 4
- 244000269722 Thea sinensis Species 0.000 claims abstract 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 43
- 235000001167 Melaleuca cajuputi Nutrition 0.000 claims description 32
- 241000378544 Melaleuca quinquenervia Species 0.000 claims description 32
- 235000017710 Melaleuca viridiflora Nutrition 0.000 claims description 32
- 239000000084 colloidal system Substances 0.000 claims description 24
- 238000003756 stirring Methods 0.000 claims description 24
- 239000011259 mixed solution Substances 0.000 claims description 20
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical group C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 18
- 239000011734 sodium Substances 0.000 claims description 18
- 229910052708 sodium Inorganic materials 0.000 claims description 18
- 241000428811 Alternanthera Species 0.000 claims description 12
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 11
- 239000002562 thickening agent Substances 0.000 claims description 11
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 10
- 229920002125 Sokalan® Polymers 0.000 claims description 9
- 229960001631 carbomer Drugs 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 7
- 239000004094 surface-active agent Substances 0.000 claims description 6
- 239000010684 cajeput oil Substances 0.000 claims description 4
- 239000007788 liquid Substances 0.000 claims description 3
- 239000008367 deionised water Substances 0.000 claims description 2
- 229910021641 deionized water Inorganic materials 0.000 claims description 2
- 239000012153 distilled water Substances 0.000 claims description 2
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 23
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract description 15
- 230000001954 sterilising effect Effects 0.000 abstract description 13
- 230000000694 effects Effects 0.000 abstract description 9
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 4
- 239000003899 bactericide agent Substances 0.000 abstract description 4
- 230000007794 irritation Effects 0.000 abstract description 4
- 241000378467 Melaleuca Species 0.000 abstract description 3
- 239000000419 plant extract Substances 0.000 abstract description 2
- 230000003313 weakening effect Effects 0.000 abstract description 2
- 241001122767 Theaceae Species 0.000 description 45
- 235000011399 aloe vera Nutrition 0.000 description 19
- 241001116389 Aloe Species 0.000 description 17
- 230000000052 comparative effect Effects 0.000 description 16
- 239000000243 solution Substances 0.000 description 15
- 241000894006 Bacteria Species 0.000 description 13
- 230000002147 killing effect Effects 0.000 description 10
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 8
- 230000003020 moisturizing effect Effects 0.000 description 6
- 238000012360 testing method Methods 0.000 description 5
- 239000000126 substance Substances 0.000 description 4
- 229920000742 Cotton Polymers 0.000 description 3
- 235000011187 glycerol Nutrition 0.000 description 3
- 239000013641 positive control Substances 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 2
- 244000144927 Aloe barbadensis Species 0.000 description 2
- 235000002961 Aloe barbadensis Nutrition 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 206010013786 Dry skin Diseases 0.000 description 2
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 2
- 241000191967 Staphylococcus aureus Species 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 230000003385 bacteriostatic effect Effects 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 239000003085 diluting agent Substances 0.000 description 2
- 230000037336 dry skin Effects 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000013642 negative control Substances 0.000 description 2
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 1
- RFIMISVNSAUMBU-UHFFFAOYSA-N 2-(hydroxymethyl)-2-(prop-2-enoxymethyl)propane-1,3-diol Chemical compound OCC(CO)(CO)COCC=C RFIMISVNSAUMBU-UHFFFAOYSA-N 0.000 description 1
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 1
- WFJIVOKAWHGMBH-UHFFFAOYSA-N 4-hexylbenzene-1,3-diol Chemical compound CCCCCCC1=CC=C(O)C=C1O WFJIVOKAWHGMBH-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 241000193403 Clostridium Species 0.000 description 1
- 241000711573 Coronaviridae Species 0.000 description 1
- JDRSMPFHFNXQRB-CMTNHCDUSA-N Decyl beta-D-threo-hexopyranoside Chemical compound CCCCCCCCCCO[C@@H]1O[C@H](CO)C(O)[C@H](O)C1O JDRSMPFHFNXQRB-CMTNHCDUSA-N 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 241000208680 Hamamelis mollis Species 0.000 description 1
- NIPNSKYNPDTRPC-UHFFFAOYSA-N N-[2-oxo-2-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(CNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 NIPNSKYNPDTRPC-UHFFFAOYSA-N 0.000 description 1
- AFCARXCZXQIEQB-UHFFFAOYSA-N N-[3-oxo-3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(CCNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 AFCARXCZXQIEQB-UHFFFAOYSA-N 0.000 description 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 241000194017 Streptococcus Species 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 235000014104 aloe vera supplement Nutrition 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000019771 cognition Effects 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 239000003431 cross linking reagent Substances 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 229940073499 decyl glucoside Drugs 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000004088 foaming agent Substances 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 239000008269 hand cream Substances 0.000 description 1
- 230000002949 hemolytic effect Effects 0.000 description 1
- 229960003258 hexylresorcinol Drugs 0.000 description 1
- 229920001477 hydrophilic polymer Polymers 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 238000000622 liquid--liquid extraction Methods 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000002906 microbiologic effect Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 230000009972 noncorrosive effect Effects 0.000 description 1
- 229960005323 phenoxyethanol Drugs 0.000 description 1
- 239000002798 polar solvent Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229960004063 propylene glycol Drugs 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000004088 simulation Methods 0.000 description 1
- 230000036620 skin dryness Effects 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 229940092665 tea leaf extract Drugs 0.000 description 1
- ICUTUKXCWQYESQ-UHFFFAOYSA-N triclocarban Chemical compound C1=CC(Cl)=CC=C1NC(=O)NC1=CC=C(Cl)C(Cl)=C1 ICUTUKXCWQYESQ-UHFFFAOYSA-N 0.000 description 1
- 229960001325 triclocarban Drugs 0.000 description 1
- 229960003500 triclosan Drugs 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 229940118846 witch hazel Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical & Material Sciences (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention relates to a plant type no-clean hand sanitizer for children and a preparation method thereof. The plant-type no-clean hand sanitizer for children contains tea extract, aloe extract and purified essential oil; the tea tree extract is tea polyphenol; the purified essential oil is a mixture of lemon peel oil, melaleuca alternifolia oil and melaleuca alternifolia oil. The invention also provides a preparation method of the tea polyphenol and ethanol double-disinfection washing-free hand sanitizer. The plant type no-clean hand sanitizer for children disclosed by the invention takes natural plant extracts of tea polyphenol, lemon peel oil, melaleuca viridis leaf oil and melaleuca alternifolia leaf oil as main bactericides, and benzalkonium chloride is added according to the actual sterilization requirement, so that the irritation to the skin of a human body is minimum on the premise of not weakening the sterilization and bacteriostasis effects, and the plant type no-clean hand sanitizer is particularly suitable for children.
Description
Technical Field
The invention relates to the technical field of hand sanitizer, in particular to a plant type no-clean hand sanitizer for children and a preparation method thereof.
Background
Along with the improvement of living standard of people, health consciousness is also increasing day by day, especially the infection of coronavirus in the world which is outbreak in the early 2020, the cognition of people on sterilization products is further enhanced, and pregnant babies and children as special social groups are more protected safely to prevent the invasion of more bacteria and viruses.
The existing wash-free hand sanitizer on the market at present has various types, wherein the broad-spectrum disinfection and sterilization wash-free hand sanitizer is the most common hand sanitizer, and in order to achieve the effects of sterilization, disinfection, bacteriostasis and cleaning, ethanol is often used as a main component in the wash-free hand sanitizer or chemical components such as triclocarban, triclosan, hexylresorcinol and the like are added in the wash-free hand sanitizer. However, ethanol and the chemical components have certain irritation to skin and are more obvious to children.
Chinese patent document CN110897914A discloses a foam-type no-clean hand sanitizer and a preparation method thereof, wherein the hand sanitizer is prepared from the following raw materials in parts by weight: 0.1-1 part of decyl glucoside, 0.4-4 parts of foaming agent, 0.01-0.1 part of benzalkonium chloride, 0.5-5 parts of glycerol, 200.1-1 parts of polysorbate-1, 0.01-0.1 part of witch hazel extract, 0.01-0.1 part of aloe extract, 0.2-1 part of phenoxyethanol, 0.01-0.5 part of essence and the balance of deionized water to 100. The no-clean hand sanitizer has a complex formula, increases the production cost and the skin burden and the use safety of children.
Therefore, the development of a natural, mild, non-irritant, non-corrosive, environment-friendly and pollution-free hand sanitizer suitable for children is particularly important.
Disclosure of Invention
Aiming at the technical problems, the invention provides a plant type no-clean hand sanitizer for children and a preparation method thereof.
The technical problem to be solved by the invention is as follows: the sterilization capability of the conventional plant no-clean hand sanitizer is improved, and on the premise of ensuring the sterilization capability, the pure plant extracted and purified essential oil and the tea polyphenol are added for assisting sterilization, so that the use amount of a chemical bactericide is reduced, the existence of staphylococcus aureus, mould, escherichia coli, clostridium and the like on hands is reduced, and the spectrum range of the sterilization bacteria is expanded; meanwhile, the aloe skin-care moisturizing component is used, so that the use of chemical moisturizing skin-care components such as glycerin, isopropyl myristate and vitamin E is reduced or even not added, the irritation to the skin is reduced, and the aloe skin-care moisturizing cream is more suitable for children.
Description of terms:
tea polyphenols, which is tea extract, is prepared by ultrasonic soaking tea with polar solvent, performing liquid-liquid extraction separation on the extractive solution, and concentrating;
carbomer is a polymer formed by copolymerizing acrylic acid serving as a monomer and sucrose acrylate ether or pentaerythritol allyl ether serving as a cross-linking agent. Is a hydrophilic polymer compound and is commercially available.
The technical scheme of the invention is as follows:
a plant-type no-clean hand sanitizer for children is characterized by containing tea extract, aloe extract and purified essential oil; the tea extract is tea polyphenol; the purified essential oil is a mixture of lemon peel oil, melaleuca alternifolia oil and melaleuca alternifolia oil.
Preferably, in the plant-type no-clean hand sanitizer for children, the content of tea polyphenol is 0.5-20%; further preferably 0.8-15%; are all in mass percent.
Preferably, in the plant-type no-clean hand sanitizer for children, the content of the aloe extract is 0.05-8% by mass.
Preferably, in the plant-type no-clean hand sanitizer for children, the content of lemon peel oil is 0.001-0.01%, the content of green flower cajeput leaf oil is 0.006-0.01%, and the content of alternate leaf cajeput leaf oil is 0.006-0.01%, all in percentage by mass.
Preferably, the plant-type no-clean hand sanitizer for children also contains benzalkonium chloride, and the content of the benzalkonium chloride is 0-0.3%; more preferably 0 to 0.2 percent by mass.
Preferably, the plant-type children-used no-clean hand sanitizer further comprises a surfactant, wherein the surfactant is sodium cocoyl amphoacetate, and the content of the surfactant is 0-1.8% by mass. The surfactant acts to promote good dissolution of the purified essential oil in the leave-on hand sanitizer.
Preferably, the plant-type children's leave-in hand sanitizer also contains a thickening agent, wherein the thickening agent is carbomer-2020, U20, carbomer-470, carbomer-471 or cellulose-based thickening agent; more preferably, the content of the thickener is 0.05 to 2 mass%.
A preferred embodiment of the present invention is as follows:
a plant-type no-clean hand sanitizer for children comprises the following components in percentage by mass: 0.8-15% of tea polyphenol, 0.001-0.005% of lemon peel oil, 0.005-0.01% of green flower cajeput leaf oil, 0.005-0.01% of alternate leaf cajeput leaf oil, 0.05-5% of aloe extract, 0.05-0.2% of benzalkonium chloride, 0.5-1.8% of sodium cocoyl amphoacetate, 0.05-0.5% of thickening agent and the balance of water.
More preferably, the embodiments of the present invention are as follows:
a plant-type no-clean hand sanitizer for children comprises the following components in percentage by mass: 0.8-10% of tea polyphenol, 0.001-0.003% of lemon peel oil, 0.006-0.008% of green flower cajeput leaf oil, 0.006-0.008% of alternate leaf cajeput leaf oil, 0.08-3% of aloe extract, 0.08-0.2% of benzalkonium chloride, 0.5-1.0% of sodium cocoyl amphoacetate, 0.05-0.2% of thickening agent and the balance of water.
A preparation method of a plant-type no-clean hand sanitizer for children comprises the following steps:
(1) adding carbomer into water containing tea polyphenol and aloe extract according to a certain proportion, standing overnight to enable the carbomer to absorb water and swell, and adjusting the pH value to 6-8 to obtain carbomer gel containing tea polyphenol and aloe extract;
(2) adding lemon peel oil, green flower cajeput oil, alternanthera cajeput oil, sodium cocoyl amphoacetate and benzalkonium chloride into water according to a proportion, and fully stirring for dissolving to obtain a uniformly dispersed mixed solution;
(3) and (3) adding the colloid in the step (1) into the mixed liquid in the step (2), and fully stirring for 1-5 hours to obtain the no-clean hand sanitizer gel.
Preferably, the pH is adjusted to triethanolamine. The acid-base property of the swelling colloid is adjusted, and the viscosity and transparency of the colloid are further adjusted.
Preferably, the water is distilled water.
The tea polyphenols, purified essential oils and aloe extracts described in this invention are commercially available or can be prepared according to the prior art.
The invention has the technical characteristics and beneficial effects that:
(1) the no-clean hand sanitizer takes natural plant extracts of tea polyphenol, lemon peel oil, melaleuca viridis leaf oil and melaleuca alternifolia leaf oil as main bactericides, benzalkonium chloride is added according to actual sterilization requirements, the irritation to the skin of a human body is minimized on the premise that the sterilization and bacteriostasis effects are not weakened, and meanwhile, the aloe extract is used as a skin care component for moisturizing, moisturizing and repairing plants and the like, so that the purpose of moisturizing and caring the skin can be effectively achieved.
(2) The no-clean hand sanitizer provided by the invention has good sterilizing and bacteriostatic capabilities, is rich and easily available in raw materials, easy to biodegrade, safe to use, low in cost, simple in preparation method and suitable for large-scale production.
Detailed Description
The present invention is further illustrated by, but not limited to, the following examples.
The tea extract, purified essential oil, aloe extract and other raw materials in the examples are commercially available. Wherein the tea polyphenols are tea leaf extract, the purified essential oil is a mixture of lemon peel oil, green flower cajeput leaf oil and alternate leaf cajeput leaf oil, and the aloe extract is commercially available aloe barbadensis extract produced from aloe barbadensis base, Yuannan Yuanjiang.
The carbomer colloids used in the examples were prepared as follows:
example 1:
a preparation method of a plant-type no-clean hand sanitizer for children comprises the following steps:
(1) adding 20g tea polyphenols and 10g Aloe extractive solution into 968g water, dissolving, adding 2g carbomer-2020, standing overnight to make carbomer-2020 absorb water and swell, adding triethanolamine to adjust pH to 7 to obtain colloid containing tea polyphenols and Aloe extractive solution;
(2) adding 0.0002g of lemon peel oil, 0.0012g of green flower cajeput leaf oil, 0.0012g of alternanthera cajeput leaf oil, 0.1g of sodium cocoyl amphoacetate and 0.02g of benzalkonium chloride into 9.8774g of water, and fully stirring and dissolving to obtain a uniformly dispersed mixed solution;
(3) and (3) adding 10g of the colloid containing the tea polyphenol and the aloe extract prepared in the step (1) into the mixed solution obtained in the step (2), and fully stirring for 4h to obtain the plant type no-clean hand sanitizer for children.
Example 2:
a preparation method of a plant-type no-clean hand sanitizer for children comprises the following steps:
(1) adding 20g tea polyphenols and 10g Aloe extractive solution into 968g water, dissolving, adding 2g carbomer-2020, standing overnight to make carbomer-2020 absorb water and swell, adding triethanolamine to adjust pH to 6 to obtain colloid containing tea polyphenols and Aloe extractive solution;
(2) adding 0.0004g of lemon peel oil, 0.0012g of green flower cajeput leaf oil, 0.0012g of alternanthera cajeput leaf oil, 0.1g of sodium cocoyl amphoacetate and 0.02g of benzalkonium chloride into 9.8772g of water, and fully stirring and dissolving to obtain a uniformly dispersed mixed solution;
(3) and (3) adding 10g of the colloid containing the tea polyphenol and the aloe extract prepared in the step (1) into the mixed solution obtained in the step (2), and fully stirring for 4h to obtain the plant type no-clean hand sanitizer for children.
Example 3:
a preparation method of a plant-type no-clean hand sanitizer for children comprises the following steps:
(1) adding 20g tea polyphenols and 10g Aloe extractive solution into 968g water, dissolving, adding 2g carbomer-2020, standing overnight to make carbomer-2020 absorb water and swell, adding triethanolamine to adjust pH to 7 to obtain colloid containing tea polyphenols and Aloe extractive solution;
(2) adding 0.0002g of lemon peel oil, 0.0015g of green flower cajeput leaf oil, 0.0012g of alternanthera cajeput leaf oil, 0.1g of sodium cocoyl amphoacetate and 0.02g of benzalkonium chloride into 9.8771g of water, and fully stirring and dissolving to obtain a uniformly dispersed mixed solution;
(3) and (3) adding 10g of the colloid containing the tea polyphenol and the aloe extract prepared in the step (1) into the mixed solution obtained in the step (2), and fully stirring for 4h to obtain the plant type no-clean hand sanitizer for children.
Example 4:
a preparation method of a plant-type no-clean hand sanitizer for children comprises the following steps:
(1) adding 20g tea polyphenols and 10g Aloe extractive solution into 968g water, dissolving, adding 2g carbomer-2020, standing overnight to make carbomer-2020 absorb water and swell, adding triethanolamine to adjust pH to 6 to obtain colloid containing tea polyphenols and Aloe extractive solution;
(2) adding 0.0002g of lemon peel oil, 0.0012g of green flower cajeput leaf oil, 0.0015g of alternanthera cajeput leaf oil, 0.1g of sodium cocoyl amphoacetate and 0.02g of benzalkonium chloride into 9.8771g of water, and fully stirring and dissolving to obtain a uniformly dispersed mixed solution;
(3) and (3) adding 10g of the colloid containing the tea polyphenol and the aloe extract prepared in the step (1) into the mixed solution obtained in the step (2), and fully stirring for 4h to obtain the plant type no-clean hand sanitizer for children.
Example 5:
a preparation method of a plant-type no-clean hand sanitizer for children comprises the following steps:
(1) adding 20g tea polyphenols and 10g Aloe extractive solution into 968g water, dissolving, adding 2g carbomer-2020, standing overnight to make carbomer-2020 absorb water and swell, adding triethanolamine to adjust pH to 7 to obtain colloid containing tea polyphenols and Aloe extractive solution;
(2) adding 0.0002g of lemon peel oil, 0.0012g of green flower cajeput leaf oil, 0.0012g of alternanthera cajeput leaf oil, 0.15g of sodium cocoyl amphoacetate and 0.02g of benzalkonium chloride into 9.8274g of water, and fully stirring and dissolving to obtain a uniformly dispersed mixed solution;
(3) and (3) adding 10g of the colloid containing the tea polyphenol and the aloe extract prepared in the step (1) into the mixed solution obtained in the step (2), and fully stirring for 4h to obtain the plant type no-clean hand sanitizer for children.
Example 6:
a preparation method of a plant-type no-clean hand sanitizer for children comprises the following steps:
(1) adding 20g tea polyphenols and 10g Aloe extractive solution into 968g water, dissolving, adding 2g carbomer-2020, standing overnight to make carbomer-2020 absorb water and swell, adding triethanolamine to adjust pH to 6 to obtain colloid containing tea polyphenols and Aloe extractive solution;
(2) adding 0.0002g of lemon peel oil, 0.0012g of green flower cajeput leaf oil, 0.0012g of alternanthera cajeput leaf oil, 0.1g of sodium cocoyl amphoacetate and 0.03g of benzalkonium chloride into 9.8674g of water, and fully stirring and dissolving to obtain a uniformly dispersed mixed solution;
(3) and (3) adding 10g of the colloid containing the tea polyphenol and the aloe extract prepared in the step (1) into the mixed solution obtained in the step (2), and fully stirring for 4h to obtain the plant type no-clean hand sanitizer for children.
Example 7:
a preparation method of a plant-type no-clean hand sanitizer for children comprises the following steps:
(1) adding 18g tea polyphenols and 10g Aloe extract into 970g water, dissolving, adding 2g carbomer-2020, standing overnight to make carbomer-2020 absorb water and swell, adding triethanolamine to adjust pH to 7 to obtain colloid containing tea polyphenols and Aloe extract;
(2) adding 0.0002g of lemon peel oil, 0.0012g of green flower cajeput leaf oil, 0.0012g of alternanthera cajeput leaf oil, 0.1g of sodium cocoyl amphoacetate and 0.02g of benzalkonium chloride into 9.8774g of water, and fully stirring and dissolving to obtain a uniformly dispersed mixed solution;
(3) and (3) adding 10g of the colloid containing the tea polyphenol and the aloe extract prepared in the step (1) into the mixed solution obtained in the step (2), and fully stirring for 4h to obtain the plant type no-clean hand sanitizer for children.
Example 8:
a preparation method of a plant-type no-clean hand sanitizer for children comprises the following steps:
(1) adding 20g tea polyphenols and 8g Aloe extractive solution into 970g water, dissolving, adding 2g carbomer-2020, standing overnight to make carbomer-2020 absorb water and swell, adding triethanolamine to adjust pH to 6 to obtain colloid containing tea polyphenols and Aloe extractive solution;
(2) adding 0.0002g of lemon peel oil, 0.0012g of green flower cajeput leaf oil, 0.0012g of alternanthera cajeput leaf oil, 0.1g of sodium cocoyl amphoacetate and 0.02g of benzalkonium chloride into 9.8774g of water, and fully stirring and dissolving to obtain a uniformly dispersed mixed solution;
(3) and (3) adding 10g of the colloid containing the tea polyphenol and the aloe extract prepared in the step (1) into the mixed solution obtained in the step (2), and fully stirring for 4h to obtain the plant type no-clean hand sanitizer for children.
Example 9:
a preparation method of a plant-type no-clean hand sanitizer for children comprises the following steps:
(1) adding 20g tea polyphenols and 10g Aloe extract into 969g water, dissolving, adding 1g carbomer-2020, standing overnight to make carbomer-2020 absorb water and swell, adding triethanolamine to adjust pH to 7 to obtain colloid containing tea polyphenols and Aloe extract;
(2) adding 0.0002g of lemon peel oil, 0.0012g of green flower cajeput leaf oil, 0.0012g of alternanthera cajeput leaf oil, 0.1g of sodium cocoyl amphoacetate and 0.02g of benzalkonium chloride into 9.8774g of water, and fully stirring and dissolving to obtain a uniformly dispersed mixed solution;
(3) and (3) adding 10g of the colloid containing the tea polyphenol and the aloe extract prepared in the step (1) into the mixed solution obtained in the step (2), and fully stirring for 4h to obtain the plant type no-clean hand sanitizer for children.
Comparative example 1
A plant-type no-clean hand sanitizer for children is prepared by the same method as in example 1, except that tea polyphenol and aloe extract are not added in the step (1).
Comparative example 2
A plant-type no-clean hand sanitizer for children is prepared by the same method as in example 1, except that lemon peel oil, green flower cajeput leaf oil and alternanthera cajeput leaf oil are not added in the step (2).
Comparative example 3
A preparation method of a tea tree essential oil and ethanol double-disinfection wash-free hand sanitizer comprises the following steps:
adding 0.5g of glycerol, 0.05g of 1, 2-propylene glycol, 0.1g of isopropyl myristate, 0.02g of benzyldione-4 and 100 microliters of tea tree essential oil into 7.5g of 95% ethanol, fully stirring for dissolving, adding 2.5g of carbomer colloid, and fully stirring for 2 hours to obtain the hand sanitizer with the ethanol content of 67% by mass.
Experimental example 1 bacteriostatic test
The product microbiological indicator should comply with the regulations of table 1.
TABLE 1
| Item | Index (I) |
| Total bacterial colony count (cfu/g or cfu/mL) | ≤200 |
| Total fungal colony count (cfu/g or cfu/mL) | ≤100 |
| Coliform group bacteria | Cannot be detected |
| Staphylococcus aureus | Cannot be detected |
| Pseudomonas aeruginosa | Cannot be detected |
| Hemolytic streptococcus | Cannot be detected |
According to the instruction of the product, the microorganism killing effect meets the specification of the table 2.
TABLE 2
The bacteria simulation experiments were performed on the wash-free hand cleaners of examples 1-5 according to the above method, and the results were the same as those in table 1, except that all the bacterial colonies in the petri dishes to which the hand cleaners were added were 0.
Test example 2
(1) Hand disinfection field experiment: subjects were randomly selected 40 according to Disinfection Specification 2002. Before disinfection, the testee rubs with both hands to make the natural bacteria distribution of both hands nearly equal, and after the aseptic cotton swab is soaked in diluent and is firstly sampled with one hand, the sampling end of the cotton swab is cut into a neutralization reagent to be used as a positive control group sample. The other hand was sterilized for 1min using the samples of the leave-in hand cleaners prepared in examples 1 to 3 and comparative examples 1 to 3, and the residual natural bacteria on the hand were sampled once in the same manner as the positive control after sterilization and used as the sample of the test group. The unused neutralizer, cotton swab and diluent in the same batch are respectively used as negative control group samples. Respectively taking 1mL of samples of the test group, the positive control group and the negative control group, inoculating the samples into the plates by an agar pouring method, inoculating 2 plates into each sample, placing the samples into a 37 ℃ incubator for culturing for 48 hours, and observing the final result. The average killing logarithm value of natural bacteria on hands of 40 persons 1.00 can be judged as qualified disinfection.
(2) Cost: and calculating the unit price of each component in the market.
The measurement results are shown in table 3.
TABLE 3
| Sample (I) | Average killing log number >1, number of people | Average killing log number >3, number of people | Cost (Yuan/kg) |
| Example 1 | 40 | 30 | 10 |
| Example 2 | 40 | 30 | 10.5 |
| Example 3 | 40 | 30 | 10.5 |
| Comparative example 1 | 30 | 20 | 8 |
| Comparative example 2 | 35 | 25 | 8.5 |
| Comparative example 3 | 40 | 30 | 14 |
As can be seen from table 3, the numbers of the natural bacteria in the no-wash hand sanitizers prepared in examples 1 to 3 with the average killing logarithm value of 1 all reach 40, the numbers of the natural bacteria with the average killing logarithm value of 3 all reach more than 30, the numbers of the natural bacteria in the no-wash hand sanitizer prepared in comparative example 1 with the average killing logarithm value of 1 are 30, the numbers of the natural bacteria with the average killing logarithm value of 3 are 20, the numbers of the natural bacteria with the average killing logarithm value of 1 in the no-wash hand sanitizer prepared in comparative example 2 are 35, and the numbers of the natural bacteria with the average killing logarithm value of 3 are 25, which indicates that the tea polyphenol and ethanol double-disinfection no-wash hand sanitizer prepared in the present invention has a better disinfection effect than that of comparative examples 1 to 2. The sterilization and disinfection effect of the comparative example 3 reaches the level of the examples 1-3, but the cost of the tea tree essential oil serving as the main component is high, and the no-clean hand sanitizer disclosed by the invention can reduce the cost by 20% on the premise of not weakening the effect, and is suitable for expanded production and wider crowds.
Test example 3
The use of the no-clean hand sanitizer prepared in example 1, the no-clean hand sanitizer sold in the market (containing alcohol and bactericide in a compound way) and the no-clean hand sanitizers prepared in comparative examples 1-2 is compared by selecting 100 persons with the age of 20-40 years and 25 persons in each group. The dry skin, neutral skin and mixability ratios were about the same in each group.
The using method comprises the following steps: the product is used 3 times per day before meals in the morning, at noon and at night, and other hand washing liquid and hand cream are not used during use; the results after one week of continuous use are shown in Table 4.
TABLE 4
| Sample (I) | People with sticky feeling | Number of people with dry skin | Number of people peeling | Number of irritating people |
| Example 1 | 2 | 1 | 0 | 0 |
| Comparative example 1 | 3 | 4 | 0 | 1 |
| Comparative example 2 | 4 | 3 | 0 | 2 |
| Commercially available product | 3 | 18 | 6 | 6 |
As can be seen from table 4, the no-wash hand sanitizer prepared in example 1 of the present invention has a more significant effect of preventing skin dryness due to the addition of the aloe vera extract compared to comparative example 1, has a more significant effect of preventing skin irritation due to the addition of the lemon peel oil, the melaleuca viridis oil, and the melaleuca alternifolia oil compared to comparative example 2, and has a better effect in various aspects compared to commercially available products.
Claims (10)
1. A plant-type no-clean hand sanitizer for children is characterized by containing tea extract, aloe extract and purified essential oil; the tea tree extract is tea polyphenol; the purified essential oil is a mixture of lemon peel oil, melaleuca alternifolia oil and melaleuca alternifolia oil.
2. The plant-type no-clean hand sanitizer for children as claimed in claim 1, wherein the content of tea polyphenol is 0.5-20%; further preferably 0.8-15%; are all in mass percent.
3. The plant-type no-clean hand sanitizer for children as claimed in claim 1, wherein the aloe extract is 0.05-8%, the lemon peel oil is 0.001-0.01%, the melaleuca alternifolia leaf oil is 0.006-0.01%, and the melaleuca alternifolia leaf oil is 0.006-0.01%, all by mass%.
4. The plant-type no-clean hand sanitizer for children as claimed in claim 1, further comprising benzalkonium chloride, wherein the content of benzalkonium chloride is 0-0.3%; more preferably 0 to 0.2 percent by mass.
5. The plant-type no-clean hand sanitizer for children as claimed in claim 1, further comprising a surfactant, wherein the surfactant is sodium cocoyl amphoacetate, and the content of the sodium cocoyl amphoacetate is 0-1.8% by mass.
6. The botanical leave-on hand sanitizer according to claim 1, wherein the thickener is carbomer-2020, U20, carbomer-470, carbomer-471, or cellulosic thickeners; more preferably, the content of the thickener is 0.05 to 2 mass%.
7. The plant-type no-clean hand sanitizer for children as claimed in claim 1, wherein the plant-type no-clean hand sanitizer for children comprises the following components in percentage by mass: 0.8-15% of tea polyphenol, 0.001-0.005% of lemon peel oil, 0.005-0.01% of green flower cajeput leaf oil, 0.005-0.01% of alternate leaf cajeput leaf oil, 0.05-5% of aloe extract, 0.05-0.2% of benzalkonium chloride, 0.5-1.8% of sodium cocoyl amphoacetate, 0.05-0.5% of thickening agent and the balance of water.
8. The plant-type no-clean hand sanitizer for children as claimed in claim 1, wherein the plant-type no-clean hand sanitizer for children comprises the following components in percentage by mass: 0.8-10% of tea polyphenol, 0.001-0.003% of lemon peel oil, 0.006-0.008% of green flower cajeput leaf oil, 0.006-0.008% of alternate leaf cajeput leaf oil, 0.08-3% of aloe extract, 0.08-0.2% of benzalkonium chloride, 0.5-1.0% of sodium cocoyl amphoacetate, 0.05-0.2% of thickening agent and the balance of water.
9. A method of preparing a plant-based leave-on hand sanitizer according to any of claims 1 to 8, comprising the steps of:
(1) adding carbomer into water containing tea polyphenol and aloe extract according to a certain proportion, standing overnight to enable the carbomer to absorb water and swell, and adjusting the pH value to 6-8 to obtain carbomer gel containing tea polyphenol and aloe extract;
(2) adding lemon peel oil, green flower cajeput oil, alternanthera cajeput oil, sodium cocoyl amphoacetate and benzalkonium chloride into water according to a proportion, and fully stirring for dissolving to obtain a uniformly dispersed mixed solution;
(3) and (3) adding the colloid in the step (1) into the mixed liquid in the step (2), and fully stirring for 1-5 hours to obtain the no-clean hand sanitizer gel.
10. The method of preparing a plant-based leave-on hand sanitizer for children as claimed in claim 9, wherein said pH is adjusted to triethanolamine in step (1); the water is distilled water or deionized water.
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| CN101684435A (en) * | 2008-09-28 | 2010-03-31 | 福建恒安集团有限公司 | Sterilization hand washing solution |
| CN105963477A (en) * | 2016-05-25 | 2016-09-28 | 山西省农业科学院高粱研究所 | Pure plant disposable sterilizing gel and preparation method thereof |
| CN106665700A (en) * | 2016-12-07 | 2017-05-17 | 张树清 | Botanical disinfection composition, disinfectant and preparation method thereof |
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