CN101679463B - 制备氧化磷脂的改进方法 - Google Patents

制备氧化磷脂的改进方法 Download PDF

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Publication number
CN101679463B
CN101679463B CN200880006707.6A CN200880006707A CN101679463B CN 101679463 B CN101679463 B CN 101679463B CN 200880006707 A CN200880006707 A CN 200880006707A CN 101679463 B CN101679463 B CN 101679463B
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compound
group
glycerol backbone
glycerol
purifying
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Expired - Fee Related
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CN200880006707.6A
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Chinese (zh)
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CN101679463A (zh
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G·哈尔佩林
E·科瓦莱夫斯基-伊谢
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Notable Labs Ltd
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Vascular Biogenics Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B41/00—Formation or introduction of functional groups containing oxygen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin
    • C07F9/106—Adducts, complexes, salts of phosphatides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/48—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by oxidation reactions with formation of hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/26—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/16—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/16—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation
    • C07C51/29—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation with halogen-containing compounds which may be formed in situ
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/08—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/28—Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/39—Preparation of carboxylic acid esters by oxidation of groups which are precursors for the acid moiety of the ester
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CN200880006707.6A 2007-01-09 2008-01-02 制备氧化磷脂的改进方法 Expired - Fee Related CN101679463B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11/650,973 US7807847B2 (en) 2004-07-09 2007-01-09 Process for the preparation of oxidized phospholipids
US11/650,973 2007-01-09
PCT/IL2008/000013 WO2008084472A2 (en) 2007-01-09 2008-01-02 Improved process for the preparation of oxidized phospholipids

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201410145506.1A Division CN103864842A (zh) 2007-01-09 2008-01-02 制备氧化磷脂的改进方法

Publications (2)

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CN101679463A CN101679463A (zh) 2010-03-24
CN101679463B true CN101679463B (zh) 2014-05-07

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CN200880006707.6A Expired - Fee Related CN101679463B (zh) 2007-01-09 2008-01-02 制备氧化磷脂的改进方法
CN201410145506.1A Pending CN103864842A (zh) 2007-01-09 2008-01-02 制备氧化磷脂的改进方法

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US (5) US7807847B2 (enExample)
EP (2) EP2125838B1 (enExample)
JP (2) JP5453109B2 (enExample)
KR (1) KR20090109095A (enExample)
CN (2) CN101679463B (enExample)
AU (1) AU2008204238B2 (enExample)
CA (2) CA2674902C (enExample)
ES (1) ES2574586T3 (enExample)
IL (1) IL199792A (enExample)
MX (1) MX2009007422A (enExample)
NZ (3) NZ578947A (enExample)
WO (1) WO2008084472A2 (enExample)
ZA (1) ZA200905601B (enExample)

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US6838452B2 (en) * 2000-11-24 2005-01-04 Vascular Biogenics Ltd. Methods employing and compositions containing defined oxidized phospholipids for prevention and treatment of atherosclerosis
US7807847B2 (en) * 2004-07-09 2010-10-05 Vascular Biogenics Ltd. Process for the preparation of oxidized phospholipids
US7784502B2 (en) 2005-04-08 2010-08-31 Air Products And Chemicals, Inc. Method and system of supply and delivery of product contained in a carrier
US9006217B2 (en) 2007-01-09 2015-04-14 Vascular Biogenics Ltd. High-purity phospholipids
US8569529B2 (en) 2007-01-09 2013-10-29 Vascular Biogenics Ltd. High-purity phospholipids
JP2010047550A (ja) * 2008-08-25 2010-03-04 Daicel Chem Ind Ltd アルコキシアルカンカルボン酸エステルの製造方法
EP2348864A4 (en) * 2008-10-08 2013-07-31 Vascular Biogenics Ltd OXIDIZED THIOPHOSPHOLIPID COMPOUNDS AND USES THEREOF
MX2011004773A (es) * 2008-11-06 2011-06-21 Vascular Biogenics Ltd Compuestos de lipido oxidados y sus usos.
US20130123781A1 (en) 2011-08-24 2013-05-16 California Institute Of Technology Targeting microbubbles
EP2750668B1 (en) 2011-09-01 2019-12-11 Vascular Biogenics Ltd. Formulations and dosage forms of oxidized phospholipids
CN104327114A (zh) * 2014-11-06 2015-02-04 江南大学 一种磷脂酰丝氨酸的制备方法
CA2968790A1 (en) 2014-11-26 2016-06-02 Vascular Biogenics Ltd. Oxidized lipids and treatment or prevention of fibrosis
US9771385B2 (en) 2014-11-26 2017-09-26 Vascular Biogenics Ltd. Oxidized lipids
CN105622665B (zh) * 2016-03-16 2017-11-24 北京美亚斯磷脂技术有限公司 一种改性大豆磷脂的制备方法
KR102208218B1 (ko) * 2016-06-30 2021-01-26 선전 와이에이치엘오 바이오텍 캄파니 리미티드 변형된 카디오리핀으로 코팅된 마그네틱 나노비드 및 그 제조 방법
CN110845357B (zh) * 2019-11-22 2022-09-30 华东理工大学 季铵盐型酰肼化合物及由其制备的季铵盐型腙类化合物与应用
CN115297865A (zh) * 2020-01-28 2022-11-04 阿普劳德医疗公司 磷脂化合物和制剂
US10953023B1 (en) 2020-01-28 2021-03-23 Applaud Medical, Inc. Phospholipid compounds and formulations
CN114195821B (zh) * 2021-12-17 2024-03-12 郑州安图生物工程股份有限公司 一种心磷脂衍生物及其制备方法和应用

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US6414168B1 (en) * 1998-12-28 2002-07-02 Caschem, Inc. Epoxidation of ricinic compounds using a phase-transfer catalyst
US6838452B2 (en) * 2000-11-24 2005-01-04 Vascular Biogenics Ltd. Methods employing and compositions containing defined oxidized phospholipids for prevention and treatment of atherosclerosis
WO2006006161A2 (en) * 2004-07-09 2006-01-19 Vascular Biogenics Ltd. Improved process for the preparation of oxidized phospholipids

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KR20090109095A (ko) 2009-10-19
IL199792A0 (en) 2010-04-15
US8759557B2 (en) 2014-06-24
WO2008084472A2 (en) 2008-07-17
US8124800B2 (en) 2012-02-28
EP2125838A4 (en) 2011-05-04
HK1135990A1 (zh) 2010-06-18
US20120130108A1 (en) 2012-05-24
NZ603980A (en) 2015-01-30
MX2009007422A (es) 2009-08-13
US20100317881A1 (en) 2010-12-16
EP2125838B1 (en) 2016-05-11
WO2008084472A3 (en) 2009-11-26
AU2008204238A1 (en) 2008-07-17
US20070112211A1 (en) 2007-05-17
CA2844908A1 (en) 2008-07-17
NZ578947A (en) 2011-08-26
US8802875B2 (en) 2014-08-12
JP5453109B2 (ja) 2014-03-26
CA2674902C (en) 2017-03-28
US20130190523A1 (en) 2013-07-25
IL199792A (en) 2013-07-31
CA2674902A1 (en) 2008-07-17
AU2008204238B2 (en) 2013-01-17
US7807847B2 (en) 2010-10-05
NZ593529A (en) 2012-12-21
EP2522672A1 (en) 2012-11-14
JP2010515721A (ja) 2010-05-13
JP2014088415A (ja) 2014-05-15
ZA200905601B (en) 2010-05-26
ES2574586T3 (es) 2016-06-20
US20130158283A1 (en) 2013-06-20
CN103864842A (zh) 2014-06-18
CN101679463A (zh) 2010-03-24
EP2125838A2 (en) 2009-12-02

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