HK1135990A1 - 改進的氧化磷脂製備方法 - Google Patents

改進的氧化磷脂製備方法

Info

Publication number
HK1135990A1
HK1135990A1 HK10102729.2A HK10102729A HK1135990A1 HK 1135990 A1 HK1135990 A1 HK 1135990A1 HK 10102729 A HK10102729 A HK 10102729A HK 1135990 A1 HK1135990 A1 HK 1135990A1
Authority
HK
Hong Kong
Prior art keywords
preparation
improved process
oxidized phospholipids
phospholipids
oxidized
Prior art date
Application number
HK10102729.2A
Other languages
English (en)
Inventor
Gideon Halperin
Eti Kovalevski-Ishai
Original Assignee
Vascular Biogenics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vascular Biogenics Ltd filed Critical Vascular Biogenics Ltd
Publication of HK1135990A1 publication Critical patent/HK1135990A1/zh

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/06Phosphorus compounds without P—C bonds
    • C07F9/08Esters of oxyacids of phosphorus
    • C07F9/09Esters of phosphoric acids
    • C07F9/10Phosphatides, e.g. lecithin
    • C07F9/106Adducts, complexes, salts of phosphatides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B41/00Formation or introduction of functional groups containing oxygen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/48Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by oxidation reactions with formation of hydroxy groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01Preparation of ethers
    • C07C41/18Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/26Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of hydroxy or O-metal groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/29Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/16Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/16Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation
    • C07C51/29Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation with halogen-containing compounds which may be formed in situ
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00Preparation of carboxylic acid esters
    • C07C67/08Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00Preparation of carboxylic acid esters
    • C07C67/28Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00Preparation of carboxylic acid esters
    • C07C67/39Preparation of carboxylic acid esters by oxidation of groups which are precursors for the acid moiety of the ester
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/06Phosphorus compounds without P—C bonds
    • C07F9/08Esters of oxyacids of phosphorus
    • C07F9/09Esters of phosphoric acids
    • C07F9/091Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/06Phosphorus compounds without P—C bonds
    • C07F9/08Esters of oxyacids of phosphorus
    • C07F9/09Esters of phosphoric acids
    • C07F9/10Phosphatides, e.g. lecithin
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
HK10102729.2A 2007-01-09 2010-03-16 改進的氧化磷脂製備方法 HK1135990A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/650,973 US7807847B2 (en) 2004-07-09 2007-01-09 Process for the preparation of oxidized phospholipids
PCT/IL2008/000013 WO2008084472A2 (en) 2007-01-09 2008-01-02 Improved process for the preparation of oxidized phospholipids

Publications (1)

Publication Number Publication Date
HK1135990A1 true HK1135990A1 (zh) 2010-06-18

Family

ID=39609128

Family Applications (1)

Application Number Title Priority Date Filing Date
HK10102729.2A HK1135990A1 (zh) 2007-01-09 2010-03-16 改進的氧化磷脂製備方法

Country Status (14)

Country Link
US (5) US7807847B2 (zh)
EP (2) EP2522672A1 (zh)
JP (2) JP5453109B2 (zh)
KR (1) KR20090109095A (zh)
CN (2) CN103864842A (zh)
AU (1) AU2008204238B2 (zh)
CA (2) CA2674902C (zh)
ES (1) ES2574586T3 (zh)
HK (1) HK1135990A1 (zh)
IL (1) IL199792A (zh)
MX (1) MX2009007422A (zh)
NZ (3) NZ593529A (zh)
WO (1) WO2008084472A2 (zh)
ZA (1) ZA200905601B (zh)

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US6838452B2 (en) 2000-11-24 2005-01-04 Vascular Biogenics Ltd. Methods employing and compositions containing defined oxidized phospholipids for prevention and treatment of atherosclerosis
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US7775245B2 (en) 2005-04-08 2010-08-17 Air Products And Chemicals, Inc. Secure loop system and method for supply and delivery of product contained in a carrier
US9006217B2 (en) 2007-01-09 2015-04-14 Vascular Biogenics Ltd. High-purity phospholipids
US8569529B2 (en) 2007-01-09 2013-10-29 Vascular Biogenics Ltd. High-purity phospholipids
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US8999960B2 (en) * 2008-10-08 2015-04-07 Vascular Biogenics Ltd. Oxidized thiophospholipid compounds and uses thereof
CN102271517B (zh) 2008-11-06 2015-04-08 脉管生物生长有限公司 氧化的脂质化合物和其用途
CN103874485B (zh) 2011-09-01 2017-06-09 脉管生物生长有限公司 氧化的磷脂的制剂和剂型
CN104327114A (zh) * 2014-11-06 2015-02-04 江南大学 一种磷脂酰丝氨酸的制备方法
ES2855299T3 (es) 2014-11-26 2021-09-23 Vascular Biogenics Ltd Lípidos oxidados y tratamiento o prevención de la fibrosis
US9771385B2 (en) 2014-11-26 2017-09-26 Vascular Biogenics Ltd. Oxidized lipids
CN105622665B (zh) * 2016-03-16 2017-11-24 北京美亚斯磷脂技术有限公司 一种改性大豆磷脂的制备方法
KR102208218B1 (ko) * 2016-06-30 2021-01-26 선전 와이에이치엘오 바이오텍 캄파니 리미티드 변형된 카디오리핀으로 코팅된 마그네틱 나노비드 및 그 제조 방법
CN110845357B (zh) * 2019-11-22 2022-09-30 华东理工大学 季铵盐型酰肼化合物及由其制备的季铵盐型腙类化合物与应用
US10953023B1 (en) 2020-01-28 2021-03-23 Applaud Medical, Inc. Phospholipid compounds and formulations
CN115297865A (zh) * 2020-01-28 2022-11-04 阿普劳德医疗公司 磷脂化合物和制剂
CN114195821B (zh) * 2021-12-17 2024-03-12 郑州安图生物工程股份有限公司 一种心磷脂衍生物及其制备方法和应用

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Also Published As

Publication number Publication date
US8759557B2 (en) 2014-06-24
NZ578947A (en) 2011-08-26
US8802875B2 (en) 2014-08-12
AU2008204238A1 (en) 2008-07-17
KR20090109095A (ko) 2009-10-19
US20130158283A1 (en) 2013-06-20
MX2009007422A (es) 2009-08-13
EP2125838A4 (en) 2011-05-04
US20100317881A1 (en) 2010-12-16
CA2674902C (en) 2017-03-28
CN101679463A (zh) 2010-03-24
CN103864842A (zh) 2014-06-18
US8124800B2 (en) 2012-02-28
JP5453109B2 (ja) 2014-03-26
NZ603980A (en) 2015-01-30
IL199792A (en) 2013-07-31
US7807847B2 (en) 2010-10-05
CA2674902A1 (en) 2008-07-17
IL199792A0 (en) 2010-04-15
ES2574586T3 (es) 2016-06-20
US20130190523A1 (en) 2013-07-25
AU2008204238B2 (en) 2013-01-17
WO2008084472A2 (en) 2008-07-17
EP2522672A1 (en) 2012-11-14
EP2125838B1 (en) 2016-05-11
WO2008084472A3 (en) 2009-11-26
NZ593529A (en) 2012-12-21
ZA200905601B (en) 2010-05-26
US20070112211A1 (en) 2007-05-17
CA2844908A1 (en) 2008-07-17
JP2010515721A (ja) 2010-05-13
JP2014088415A (ja) 2014-05-15
US20120130108A1 (en) 2012-05-24
EP2125838A2 (en) 2009-12-02
CN101679463B (zh) 2014-05-07

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Effective date: 20230106