CN101679246A - 新型吡咯啉酮衍生物以及包含其的药物组合物 - Google Patents
新型吡咯啉酮衍生物以及包含其的药物组合物 Download PDFInfo
- Publication number
- CN101679246A CN101679246A CN200880017760A CN200880017760A CN101679246A CN 101679246 A CN101679246 A CN 101679246A CN 200880017760 A CN200880017760 A CN 200880017760A CN 200880017760 A CN200880017760 A CN 200880017760A CN 101679246 A CN101679246 A CN 101679246A
- Authority
- CN
- China
- Prior art keywords
- randomly substituted
- randomly
- substituted
- group
- alkyl group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 title description 55
- HMXQIFUGFZEJEO-UHFFFAOYSA-N 1,2-dihydropyrrol-3-one Chemical class O=C1CNC=C1 HMXQIFUGFZEJEO-UHFFFAOYSA-N 0.000 title description 2
- 150000001875 compounds Chemical class 0.000 claims abstract description 187
- 150000003839 salts Chemical class 0.000 claims abstract description 55
- TZHOVNUCGUXMCS-UHFFFAOYSA-N 5-(2-ethynyl-5-propan-2-ylpyridin-4-yl)oxypyrimidine-2,4-diamine Chemical compound C(#C)C1=NC=C(C(=C1)OC=1C(=NC(=NC=1)N)N)C(C)C TZHOVNUCGUXMCS-UHFFFAOYSA-N 0.000 claims abstract description 32
- -1 hydroxylamino Chemical group 0.000 claims description 174
- 125000000217 alkyl group Chemical group 0.000 claims description 89
- 239000000126 substance Substances 0.000 claims description 66
- 125000000392 cycloalkenyl group Chemical group 0.000 claims description 50
- 125000003545 alkoxy group Chemical group 0.000 claims description 47
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 45
- 239000001257 hydrogen Substances 0.000 claims description 44
- 229910052739 hydrogen Inorganic materials 0.000 claims description 44
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 43
- 239000012453 solvate Substances 0.000 claims description 37
- 125000003107 substituted aryl group Chemical group 0.000 claims description 35
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 33
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims description 32
- 125000002252 acyl group Chemical group 0.000 claims description 28
- 150000002431 hydrogen Chemical group 0.000 claims description 24
- 125000003118 aryl group Chemical group 0.000 claims description 23
- 150000002367 halogens Chemical class 0.000 claims description 23
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 22
- 229910052736 halogen Inorganic materials 0.000 claims description 22
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 21
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 20
- 125000000547 substituted alkyl group Chemical group 0.000 claims description 18
- 125000004076 pyridyl group Chemical group 0.000 claims description 15
- 125000003342 alkenyl group Chemical group 0.000 claims description 14
- 125000004414 alkyl thio group Chemical group 0.000 claims description 13
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 13
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 13
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 13
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims description 12
- 229910052799 carbon Inorganic materials 0.000 claims description 12
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 12
- 125000000304 alkynyl group Chemical group 0.000 claims description 11
- 150000001721 carbon Chemical group 0.000 claims description 11
- 201000010099 disease Diseases 0.000 claims description 11
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 11
- 239000008194 pharmaceutical composition Substances 0.000 claims description 11
- 125000000335 thiazolyl group Chemical group 0.000 claims description 11
- 230000002265 prevention Effects 0.000 claims description 5
- JEXVQSWXXUJEMA-UHFFFAOYSA-N pyrazol-3-one Chemical compound O=C1C=CN=N1 JEXVQSWXXUJEMA-UHFFFAOYSA-N 0.000 claims description 3
- 239000002585 base Substances 0.000 description 92
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 71
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 66
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 63
- 208000002193 Pain Diseases 0.000 description 55
- 230000036407 pain Effects 0.000 description 54
- IAZDPXIOMUYVGZ-WFGJKAKNSA-N Dimethyl sulfoxide Chemical compound [2H]C([2H])([2H])S(=O)C([2H])([2H])[2H] IAZDPXIOMUYVGZ-WFGJKAKNSA-N 0.000 description 44
- 238000006243 chemical reaction Methods 0.000 description 44
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 42
- 238000002360 preparation method Methods 0.000 description 40
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 39
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 39
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 34
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 33
- 239000002904 solvent Substances 0.000 description 29
- 235000019439 ethyl acetate Nutrition 0.000 description 24
- CZDYPVPMEAXLPK-UHFFFAOYSA-N tetramethylsilane Chemical compound C[Si](C)(C)C CZDYPVPMEAXLPK-UHFFFAOYSA-N 0.000 description 24
- 238000005160 1H NMR spectroscopy Methods 0.000 description 22
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 22
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 22
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 21
- 239000011259 mixed solution Substances 0.000 description 21
- 239000013078 crystal Substances 0.000 description 20
- 239000000243 solution Substances 0.000 description 19
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 18
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 17
- 238000001556 precipitation Methods 0.000 description 17
- 238000001953 recrystallisation Methods 0.000 description 17
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 15
- APSBXTVYXVQYAB-UHFFFAOYSA-M sodium docusate Chemical compound [Na+].CCCCC(CC)COC(=O)CC(S([O-])(=O)=O)C(=O)OCC(CC)CCCC APSBXTVYXVQYAB-UHFFFAOYSA-M 0.000 description 15
- 239000003513 alkali Substances 0.000 description 14
- 239000002253 acid Substances 0.000 description 13
- 238000004440 column chromatography Methods 0.000 description 13
- 238000001914 filtration Methods 0.000 description 13
- 239000012046 mixed solvent Substances 0.000 description 13
- 230000035484 reaction time Effects 0.000 description 13
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 12
- 150000004945 aromatic hydrocarbons Chemical class 0.000 description 12
- 238000007796 conventional method Methods 0.000 description 12
- 239000004215 Carbon black (E152) Substances 0.000 description 11
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 11
- 229930195733 hydrocarbon Natural products 0.000 description 11
- 150000002430 hydrocarbons Chemical class 0.000 description 11
- AMWRITDGCCNYAT-UHFFFAOYSA-L hydroxy(oxo)manganese;manganese Chemical compound [Mn].O[Mn]=O.O[Mn]=O AMWRITDGCCNYAT-UHFFFAOYSA-L 0.000 description 11
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 11
- 125000005843 halogen group Chemical group 0.000 description 10
- 229910052760 oxygen Inorganic materials 0.000 description 10
- ZKHQWZAMYRWXGA-KQYNXXCUSA-J ATP(4-) Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)[C@H]1O ZKHQWZAMYRWXGA-KQYNXXCUSA-J 0.000 description 9
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 9
- ZKHQWZAMYRWXGA-UHFFFAOYSA-N Adenosine triphosphate Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)C(O)C1O ZKHQWZAMYRWXGA-UHFFFAOYSA-N 0.000 description 9
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 9
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 9
- 239000001301 oxygen Substances 0.000 description 9
- NFHFRUOZVGFOOS-UHFFFAOYSA-N palladium;triphenylphosphane Chemical compound [Pd].C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 NFHFRUOZVGFOOS-UHFFFAOYSA-N 0.000 description 9
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 8
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 8
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 8
- 239000012141 concentrate Substances 0.000 description 8
- 238000001035 drying Methods 0.000 description 8
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 8
- 239000012044 organic layer Substances 0.000 description 8
- RIOQSEWOXXDEQQ-UHFFFAOYSA-N triphenylphosphine Chemical compound C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-N 0.000 description 8
- 238000005406 washing Methods 0.000 description 8
- 150000001412 amines Chemical class 0.000 description 7
- 239000000047 product Substances 0.000 description 7
- 125000001422 pyrrolinyl group Chemical group 0.000 description 7
- 125000001544 thienyl group Chemical group 0.000 description 7
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 6
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 6
- PAYRUJLWNCNPSJ-UHFFFAOYSA-N Aniline Chemical compound NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 description 6
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 6
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
- 239000005864 Sulphur Substances 0.000 description 6
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 6
- 125000001691 aryl alkyl amino group Chemical group 0.000 description 6
- 210000004027 cell Anatomy 0.000 description 6
- 238000002425 crystallisation Methods 0.000 description 6
- 230000008025 crystallization Effects 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 125000003754 ethoxycarbonyl group Chemical group C(=O)(OCC)* 0.000 description 6
- 125000002636 imidazolinyl group Chemical group 0.000 description 6
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 6
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 6
- 238000010898 silica gel chromatography Methods 0.000 description 6
- 238000003756 stirring Methods 0.000 description 6
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 5
- 125000003282 alkyl amino group Chemical group 0.000 description 5
- HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Natural products C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 description 5
- 125000003368 amide group Chemical group 0.000 description 5
- 125000003710 aryl alkyl group Chemical group 0.000 description 5
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 5
- 239000003153 chemical reaction reagent Substances 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 5
- 239000000460 chlorine Substances 0.000 description 5
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 description 5
- 238000003810 ethyl acetate extraction Methods 0.000 description 5
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 description 5
- 230000005764 inhibitory process Effects 0.000 description 5
- 125000001786 isothiazolyl group Chemical group 0.000 description 5
- 229910052757 nitrogen Inorganic materials 0.000 description 5
- WCPAKWJPBJAGKN-UHFFFAOYSA-N oxadiazole Chemical compound C1=CON=N1 WCPAKWJPBJAGKN-UHFFFAOYSA-N 0.000 description 5
- 125000005646 oximino group Chemical group 0.000 description 5
- 238000010992 reflux Methods 0.000 description 5
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical class O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 5
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 5
- WSLDOOZREJYCGB-UHFFFAOYSA-N 1,2-Dichloroethane Chemical compound ClCCCl WSLDOOZREJYCGB-UHFFFAOYSA-N 0.000 description 4
- VHYFNPMBLIVWCW-UHFFFAOYSA-N 4-Dimethylaminopyridine Chemical compound CN(C)C1=CC=NC=C1 VHYFNPMBLIVWCW-UHFFFAOYSA-N 0.000 description 4
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 4
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 4
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 4
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 4
- ODFJOVXVLFUVNQ-UHFFFAOYSA-N acetarsol Chemical compound CC(=O)NC1=CC([As](O)(O)=O)=CC=C1O ODFJOVXVLFUVNQ-UHFFFAOYSA-N 0.000 description 4
- 239000000730 antalgic agent Substances 0.000 description 4
- 125000000043 benzamido group Chemical group [H]N([*])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 4
- ILAHWRKJUDSMFH-UHFFFAOYSA-N boron tribromide Chemical compound BrB(Br)Br ILAHWRKJUDSMFH-UHFFFAOYSA-N 0.000 description 4
- 229910052794 bromium Inorganic materials 0.000 description 4
- 229910052801 chlorine Inorganic materials 0.000 description 4
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 4
- UKPXULFIISGBHG-UHFFFAOYSA-N cyclopropene Chemical compound [CH]1C=C1 UKPXULFIISGBHG-UHFFFAOYSA-N 0.000 description 4
- 230000006378 damage Effects 0.000 description 4
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 description 4
- 125000000031 ethylamino group Chemical group [H]C([H])([H])C([H])([H])N([H])[*] 0.000 description 4
- 238000000605 extraction Methods 0.000 description 4
- 229910052731 fluorine Inorganic materials 0.000 description 4
- 150000005826 halohydrocarbons Chemical class 0.000 description 4
- 229910052740 iodine Inorganic materials 0.000 description 4
- 125000000842 isoxazolyl group Chemical group 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 description 4
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 description 4
- 125000002971 oxazolyl group Chemical group 0.000 description 4
- CFHIDWOYWUOIHU-UHFFFAOYSA-N oxomethyl Chemical compound O=[CH] CFHIDWOYWUOIHU-UHFFFAOYSA-N 0.000 description 4
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Substances [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 4
- 235000015320 potassium carbonate Nutrition 0.000 description 4
- 125000003226 pyrazolyl group Chemical group 0.000 description 4
- 125000000714 pyrimidinyl group Chemical group 0.000 description 4
- 239000011541 reaction mixture Substances 0.000 description 4
- 208000011580 syndromic disease Diseases 0.000 description 4
- 125000001113 thiadiazolyl group Chemical group 0.000 description 4
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 4
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 4
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 4
- 229920002554 vinyl polymer Polymers 0.000 description 4
- 239000008096 xylene Substances 0.000 description 4
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 3
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 3
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 description 3
- GUUULVAMQJLDSY-UHFFFAOYSA-N 4,5-dihydro-1,2-thiazole Chemical compound C1CC=NS1 GUUULVAMQJLDSY-UHFFFAOYSA-N 0.000 description 3
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 3
- XTHFKEDIFFGKHM-UHFFFAOYSA-N Dimethoxyethane Chemical compound COCCOC XTHFKEDIFFGKHM-UHFFFAOYSA-N 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
- 239000007995 HEPES buffer Substances 0.000 description 3
- 206010020853 Hypertonic bladder Diseases 0.000 description 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 3
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 3
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 3
- 239000005557 antagonist Substances 0.000 description 3
- 229910000085 borane Inorganic materials 0.000 description 3
- 125000004106 butoxy group Chemical group [*]OC([H])([H])C([H])([H])C(C([H])([H])[H])([H])[H] 0.000 description 3
- FJDQFPXHSGXQBY-UHFFFAOYSA-L caesium carbonate Chemical compound [Cs+].[Cs+].[O-]C([O-])=O FJDQFPXHSGXQBY-UHFFFAOYSA-L 0.000 description 3
- 229910000024 caesium carbonate Inorganic materials 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 239000013024 dilution buffer Substances 0.000 description 3
- 125000005879 dioxolanyl group Chemical group 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 239000000706 filtrate Substances 0.000 description 3
- FATAVLOOLIRUNA-UHFFFAOYSA-N formylmethyl Chemical compound [CH2]C=O FATAVLOOLIRUNA-UHFFFAOYSA-N 0.000 description 3
- SIAPCJWMELPYOE-UHFFFAOYSA-N lithium hydride Chemical compound [LiH] SIAPCJWMELPYOE-UHFFFAOYSA-N 0.000 description 3
- 229910000103 lithium hydride Inorganic materials 0.000 description 3
- 229910052751 metal Inorganic materials 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- 229910052987 metal hydride Inorganic materials 0.000 description 3
- 150000004681 metal hydrides Chemical class 0.000 description 3
- 229910000000 metal hydroxide Inorganic materials 0.000 description 3
- 150000004692 metal hydroxides Chemical class 0.000 description 3
- 125000002816 methylsulfanyl group Chemical group [H]C([H])([H])S[*] 0.000 description 3
- 230000003287 optical effect Effects 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- DBABZHXKTCFAPX-UHFFFAOYSA-N probenecid Chemical compound CCCN(CCC)S(=O)(=O)C1=CC=C(C(O)=O)C=C1 DBABZHXKTCFAPX-UHFFFAOYSA-N 0.000 description 3
- 229960003081 probenecid Drugs 0.000 description 3
- 230000005855 radiation Effects 0.000 description 3
- 102000005962 receptors Human genes 0.000 description 3
- 108020003175 receptors Proteins 0.000 description 3
- 239000001632 sodium acetate Substances 0.000 description 3
- 235000017281 sodium acetate Nutrition 0.000 description 3
- 235000017550 sodium carbonate Nutrition 0.000 description 3
- 229910000029 sodium carbonate Inorganic materials 0.000 description 3
- 239000011780 sodium chloride Substances 0.000 description 3
- 239000012312 sodium hydride Substances 0.000 description 3
- 229910000104 sodium hydride Inorganic materials 0.000 description 3
- FVAUCKIRQBBSSJ-UHFFFAOYSA-M sodium iodide Chemical compound [Na+].[I-] FVAUCKIRQBBSSJ-UHFFFAOYSA-M 0.000 description 3
- 125000004646 sulfenyl group Chemical group S(*)* 0.000 description 3
- 125000002769 thiazolinyl group Chemical group 0.000 description 3
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 3
- UORVGPXVDQYIDP-UHFFFAOYSA-N trihydridoboron Substances B UORVGPXVDQYIDP-UHFFFAOYSA-N 0.000 description 3
- LBUJPTNKIBCYBY-UHFFFAOYSA-N 1,2,3,4-tetrahydroquinoline Chemical compound C1=CC=C2CCCNC2=C1 LBUJPTNKIBCYBY-UHFFFAOYSA-N 0.000 description 2
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 2
- LMDZBCPBFSXMTL-UHFFFAOYSA-N 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide Substances CCN=C=NCCCN(C)C LMDZBCPBFSXMTL-UHFFFAOYSA-N 0.000 description 2
- PKZJLOCLABXVMC-UHFFFAOYSA-N 2-Methoxybenzaldehyde Chemical compound COC1=CC=CC=C1C=O PKZJLOCLABXVMC-UHFFFAOYSA-N 0.000 description 2
- 125000004182 2-chlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(*)C([H])=C1[H] 0.000 description 2
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 description 2
- FPQQSJJWHUJYPU-UHFFFAOYSA-N 3-(dimethylamino)propyliminomethylidene-ethylazanium;chloride Chemical compound Cl.CCN=C=NCCCN(C)C FPQQSJJWHUJYPU-UHFFFAOYSA-N 0.000 description 2
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 description 2
- 125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 description 2
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 2
- KRHYYFGTRYWZRS-UHFFFAOYSA-N Fluorane Chemical compound F KRHYYFGTRYWZRS-UHFFFAOYSA-N 0.000 description 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 2
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- 206010065390 Inflammatory pain Diseases 0.000 description 2
- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 description 2
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 description 2
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 description 2
- 208000009722 Overactive Urinary Bladder Diseases 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 206010036018 Pollakiuria Diseases 0.000 description 2
- KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Chemical compound C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 description 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical class [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 description 2
- 150000001408 amides Chemical class 0.000 description 2
- 230000000202 analgesic effect Effects 0.000 description 2
- ZRALSGWEFCBTJO-UHFFFAOYSA-N anhydrous guanidine Natural products NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 description 2
- 230000003042 antagnostic effect Effects 0.000 description 2
- 230000008485 antagonism Effects 0.000 description 2
- 239000012298 atmosphere Substances 0.000 description 2
- 150000001540 azides Chemical class 0.000 description 2
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 125000003739 carbamimidoyl group Chemical group C(N)(=N)* 0.000 description 2
- 239000001569 carbon dioxide Substances 0.000 description 2
- 229910002092 carbon dioxide Inorganic materials 0.000 description 2
- 239000003054 catalyst Substances 0.000 description 2
- 238000005660 chlorination reaction Methods 0.000 description 2
- 239000012043 crude product Substances 0.000 description 2
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 2
- 238000000354 decomposition reaction Methods 0.000 description 2
- 125000002704 decyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 2
- 125000003963 dichloro group Chemical group Cl* 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 125000006125 ethylsulfonyl group Chemical group 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- MSBPSFSYBUUPMC-UHFFFAOYSA-N furan-2-ylphosphane Chemical compound PC1=CC=CO1 MSBPSFSYBUUPMC-UHFFFAOYSA-N 0.000 description 2
- 125000000717 hydrazino group Chemical group [H]N([*])N([H])[H] 0.000 description 2
- 238000005984 hydrogenation reaction Methods 0.000 description 2
- NPZTUJOABDZTLV-UHFFFAOYSA-N hydroxybenzotriazole Substances O=C1C=CC=C2NNN=C12 NPZTUJOABDZTLV-UHFFFAOYSA-N 0.000 description 2
- 125000002883 imidazolyl group Chemical group 0.000 description 2
- 125000003406 indolizinyl group Chemical group C=1(C=CN2C=CC=CC12)* 0.000 description 2
- 125000004491 isohexyl group Chemical group C(CCC(C)C)* 0.000 description 2
- 125000001972 isopentyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 238000002386 leaching Methods 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 230000001404 mediated effect Effects 0.000 description 2
- RIFHJAODNHLCBH-UHFFFAOYSA-N methanethione Chemical group S=[CH] RIFHJAODNHLCBH-UHFFFAOYSA-N 0.000 description 2
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 2
- ITATYELQCJRCCK-QMMMGPOBSA-N methyl (2s)-2-hydroxy-2-phenylacetate Chemical class COC(=O)[C@@H](O)C1=CC=CC=C1 ITATYELQCJRCCK-QMMMGPOBSA-N 0.000 description 2
- RDOXTESZEPMUJZ-UHFFFAOYSA-N methyl phenyl ether Natural products COC1=CC=CC=C1 RDOXTESZEPMUJZ-UHFFFAOYSA-N 0.000 description 2
- 239000002808 molecular sieve Substances 0.000 description 2
- 210000000214 mouth Anatomy 0.000 description 2
- 125000001280 n-hexyl group Chemical group C(CCCCC)* 0.000 description 2
- 125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 2
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 2
- 125000001971 neopentyl group Chemical group [H]C([*])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 2
- 210000005036 nerve Anatomy 0.000 description 2
- 208000004296 neuralgia Diseases 0.000 description 2
- 208000021722 neuropathic pain Diseases 0.000 description 2
- 239000012299 nitrogen atmosphere Substances 0.000 description 2
- 125000000018 nitroso group Chemical group N(=O)* 0.000 description 2
- 208000020629 overactive bladder Diseases 0.000 description 2
- 229910052763 palladium Inorganic materials 0.000 description 2
- MUJIDPITZJWBSW-UHFFFAOYSA-N palladium(2+) Chemical compound [Pd+2] MUJIDPITZJWBSW-UHFFFAOYSA-N 0.000 description 2
- 125000005544 phthalimido group Chemical group 0.000 description 2
- 230000035479 physiological effects, processes and functions Effects 0.000 description 2
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 2
- 125000001844 prenyl group Chemical group [H]C([*])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] 0.000 description 2
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 2
- 201000007094 prostatitis Diseases 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 125000003373 pyrazinyl group Chemical group 0.000 description 2
- 125000002755 pyrazolinyl group Chemical group 0.000 description 2
- 125000002098 pyridazinyl group Chemical group 0.000 description 2
- 150000003222 pyridines Chemical class 0.000 description 2
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical group O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 2
- 125000005493 quinolyl group Chemical group 0.000 description 2
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- 125000000213 sulfino group Chemical group [H]OS(*)=O 0.000 description 2
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 description 2
- 229910000404 tripotassium phosphate Inorganic materials 0.000 description 2
- 235000019798 tripotassium phosphate Nutrition 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N urea group Chemical group NC(=O)N XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- JSLZUBLGGPEVQN-DIPNUNPCSA-N (2r)-4-methyl-2-propan-2-yl-2-[2-[4-[4-[2-(3,4,5-trimethoxyphenyl)ethyl]piperazin-1-yl]butoxy]phenyl]-1,4-benzothiazin-3-one Chemical compound COC1=C(OC)C(OC)=CC(CCN2CCN(CCCCOC=3C(=CC=CC=3)[C@@]3(C(N(C)C4=CC=CC=C4S3)=O)C(C)C)CC2)=C1 JSLZUBLGGPEVQN-DIPNUNPCSA-N 0.000 description 1
- NWZSZGALRFJKBT-KNIFDHDWSA-N (2s)-2,6-diaminohexanoic acid;(2s)-2-hydroxybutanedioic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O.NCCCC[C@H](N)C(O)=O NWZSZGALRFJKBT-KNIFDHDWSA-N 0.000 description 1
- HUWSZNZAROKDRZ-RRLWZMAJSA-N (3r,4r)-3-azaniumyl-5-[[(2s,3r)-1-[(2s)-2,3-dicarboxypyrrolidin-1-yl]-3-methyl-1-oxopentan-2-yl]amino]-5-oxo-4-sulfanylpentane-1-sulfonate Chemical compound OS(=O)(=O)CC[C@@H](N)[C@@H](S)C(=O)N[C@@H]([C@H](C)CC)C(=O)N1CCC(C(O)=O)[C@H]1C(O)=O HUWSZNZAROKDRZ-RRLWZMAJSA-N 0.000 description 1
- CSNIZNHTOVFARY-UHFFFAOYSA-N 1,2-benzothiazole Chemical compound C1=CC=C2C=NSC2=C1 CSNIZNHTOVFARY-UHFFFAOYSA-N 0.000 description 1
- KTZQTRPPVKQPFO-UHFFFAOYSA-N 1,2-benzoxazole Chemical compound C1=CC=C2C=NOC2=C1 KTZQTRPPVKQPFO-UHFFFAOYSA-N 0.000 description 1
- FKASFBLJDCHBNZ-UHFFFAOYSA-N 1,3,4-oxadiazole Chemical compound C1=NN=CO1 FKASFBLJDCHBNZ-UHFFFAOYSA-N 0.000 description 1
- YNGDWRXWKFWCJY-UHFFFAOYSA-N 1,4-Dihydropyridine Chemical compound C1C=CNC=C1 YNGDWRXWKFWCJY-UHFFFAOYSA-N 0.000 description 1
- FLBAYUMRQUHISI-UHFFFAOYSA-N 1,8-naphthyridine Chemical compound N1=CC=CC2=CC=CN=C21 FLBAYUMRQUHISI-UHFFFAOYSA-N 0.000 description 1
- 125000001637 1-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C(*)=C([H])C([H])=C([H])C2=C1[H] 0.000 description 1
- YBYIRNPNPLQARY-UHFFFAOYSA-N 1H-indene Natural products C1=CC=C2CC=CC2=C1 YBYIRNPNPLQARY-UHFFFAOYSA-N 0.000 description 1
- HGUFODBRKLSHSI-UHFFFAOYSA-N 2,3,7,8-tetrachloro-dibenzo-p-dioxin Chemical compound O1C2=CC(Cl)=C(Cl)C=C2OC2=C1C=C(Cl)C(Cl)=C2 HGUFODBRKLSHSI-UHFFFAOYSA-N 0.000 description 1
- OVSKIKFHRZPJSS-UHFFFAOYSA-N 2,4-D Chemical compound OC(=O)COC1=CC=C(Cl)C=C1Cl OVSKIKFHRZPJSS-UHFFFAOYSA-N 0.000 description 1
- 125000001622 2-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C(*)C([H])=C([H])C2=C1[H] 0.000 description 1
- 125000003504 2-oxazolinyl group Chemical group O1C(=NCC1)* 0.000 description 1
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 description 1
- UMZCLZPXPCNKML-UHFFFAOYSA-N 2h-imidazo[4,5-d][1,3]thiazole Chemical compound C1=NC2=NCSC2=N1 UMZCLZPXPCNKML-UHFFFAOYSA-N 0.000 description 1
- PIKNVEVCWAAOMJ-UHFFFAOYSA-N 3-fluorobenzaldehyde Chemical compound FC1=CC=CC(C=O)=C1 PIKNVEVCWAAOMJ-UHFFFAOYSA-N 0.000 description 1
- YHQXBTXEYZIYOV-UHFFFAOYSA-N 3-methylbut-1-ene Chemical group CC(C)C=C YHQXBTXEYZIYOV-UHFFFAOYSA-N 0.000 description 1
- GSOHKPVFCOWKPU-UHFFFAOYSA-N 3-methylpentane-2,4-dione Chemical compound CC(=O)C(C)C(C)=O GSOHKPVFCOWKPU-UHFFFAOYSA-N 0.000 description 1
- 125000001541 3-thienyl group Chemical group S1C([H])=C([*])C([H])=C1[H] 0.000 description 1
- JXGXBIODMYNLJV-UHFFFAOYSA-N 4-(1h-pyrazol-5-yl)oxadiazole Chemical compound N1C=CC(C=2N=NOC=2)=N1 JXGXBIODMYNLJV-UHFFFAOYSA-N 0.000 description 1
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 1
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 description 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- 206010000087 Abdominal pain upper Diseases 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
- 206010002556 Ankylosing Spondylitis Diseases 0.000 description 1
- 208000006820 Arthralgia Diseases 0.000 description 1
- 208000008035 Back Pain Diseases 0.000 description 1
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 description 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 1
- NUZMPIYYRKIQCG-UHFFFAOYSA-N C(=O)O.I(=O)(=O)C1=CC=CC=C1 Chemical compound C(=O)O.I(=O)(=O)C1=CC=CC=C1 NUZMPIYYRKIQCG-UHFFFAOYSA-N 0.000 description 1
- UEOQGGDCTJBMII-UHFFFAOYSA-M C(C)OC([O-])=O.[Cl+] Chemical compound C(C)OC([O-])=O.[Cl+] UEOQGGDCTJBMII-UHFFFAOYSA-M 0.000 description 1
- AWMHRVHGKOFCNI-UHFFFAOYSA-N C(CCCC)OC(C(C)(C)C)OOCCC(C)C Chemical compound C(CCCC)OC(C(C)(C)C)OOCCC(C)C AWMHRVHGKOFCNI-UHFFFAOYSA-N 0.000 description 1
- GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 206010058019 Cancer Pain Diseases 0.000 description 1
- 208000001387 Causalgia Diseases 0.000 description 1
- 206010064012 Central pain syndrome Diseases 0.000 description 1
- 206010008190 Cerebrovascular accident Diseases 0.000 description 1
- 206010008334 Cervicobrachial syndrome Diseases 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 208000000094 Chronic Pain Diseases 0.000 description 1
- 208000002881 Colic Diseases 0.000 description 1
- 208000023890 Complex Regional Pain Syndromes Diseases 0.000 description 1
- 206010063057 Cystitis noninfective Diseases 0.000 description 1
- 208000005156 Dehydration Diseases 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- OIFBSDVPJOWBCH-UHFFFAOYSA-N Diethyl carbonate Chemical compound CCOC(=O)OCC OIFBSDVPJOWBCH-UHFFFAOYSA-N 0.000 description 1
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 208000001640 Fibromyalgia Diseases 0.000 description 1
- OZLGRUXZXMRXGP-UHFFFAOYSA-N Fluo-3 Chemical compound CC1=CC=C(N(CC(O)=O)CC(O)=O)C(OCCOC=2C(=CC=C(C=2)C2=C3C=C(Cl)C(=O)C=C3OC3=CC(O)=C(Cl)C=C32)N(CC(O)=O)CC(O)=O)=C1 OZLGRUXZXMRXGP-UHFFFAOYSA-N 0.000 description 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 1
- 108091006027 G proteins Proteins 0.000 description 1
- 102000030782 GTP binding Human genes 0.000 description 1
- 108091000058 GTP-Binding Proteins 0.000 description 1
- 206010017711 Gangrene Diseases 0.000 description 1
- 201000005569 Gout Diseases 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 208000007514 Herpes zoster Diseases 0.000 description 1
- AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 description 1
- 206010021639 Incontinence Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010024229 Leprosy Diseases 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 208000019695 Migraine disease Diseases 0.000 description 1
- 206010028391 Musculoskeletal Pain Diseases 0.000 description 1
- 208000000112 Myalgia Diseases 0.000 description 1
- 208000030858 Myofascial Pain Syndromes Diseases 0.000 description 1
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical class CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 1
- JFVUACWMOZIBSQ-UHFFFAOYSA-N N1=CC=CC2=CC=CC=C12.S1CNCC1 Chemical compound N1=CC=CC2=CC=CC=C12.S1CNCC1 JFVUACWMOZIBSQ-UHFFFAOYSA-N 0.000 description 1
- UFWIBTONFRDIAS-UHFFFAOYSA-N Naphthalene Chemical compound C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 description 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
- 208000001132 Osteoporosis Diseases 0.000 description 1
- ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical compound C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 description 1
- 206010033645 Pancreatitis Diseases 0.000 description 1
- 208000018737 Parkinson disease Diseases 0.000 description 1
- 208000031481 Pathologic Constriction Diseases 0.000 description 1
- 208000030831 Peripheral arterial occlusive disease Diseases 0.000 description 1
- PCNDJXKNXGMECE-UHFFFAOYSA-N Phenazine Natural products C1=CC=CC2=NC3=CC=CC=C3N=C21 PCNDJXKNXGMECE-UHFFFAOYSA-N 0.000 description 1
- 208000004550 Postoperative Pain Diseases 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 206010051482 Prostatomegaly Diseases 0.000 description 1
- KDCGOANMDULRCW-UHFFFAOYSA-N Purine Natural products N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 description 1
- 208000012322 Raynaud phenomenon Diseases 0.000 description 1
- 201000001947 Reflex Sympathetic Dystrophy Diseases 0.000 description 1
- 206010039361 Sacroiliitis Diseases 0.000 description 1
- 208000008765 Sciatica Diseases 0.000 description 1
- 208000007613 Shoulder Pain Diseases 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- 208000020339 Spinal injury Diseases 0.000 description 1
- 206010041591 Spinal osteoarthritis Diseases 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 238000006069 Suzuki reaction reaction Methods 0.000 description 1
- 206010042928 Syringomyelia Diseases 0.000 description 1
- 206010043540 Thromboangiitis obliterans Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- PYHZXOYNICJOTG-UHFFFAOYSA-N [2-[2,4,6-tri(propan-2-yl)phenyl]phenyl]phosphane Chemical compound CC(C)C1=CC(C(C)C)=CC(C(C)C)=C1C1=CC=CC=C1P PYHZXOYNICJOTG-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- TTWYZDPBDWHJOR-IDIVVRGQSA-L adenosine triphosphate disodium Chemical compound [Na+].[Na+].C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP([O-])([O-])=O)[C@@H](O)[C@H]1O TTWYZDPBDWHJOR-IDIVVRGQSA-L 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 1
- 150000001342 alkaline earth metals Chemical class 0.000 description 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 235000019270 ammonium chloride Nutrition 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 125000005428 anthryl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C3C(*)=C([H])C([H])=C([H])C3=C([H])C2=C1[H] 0.000 description 1
- 239000003429 antifungal agent Substances 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 125000006615 aromatic heterocyclic group Chemical group 0.000 description 1
- 208000019804 backache Diseases 0.000 description 1
- 229910052728 basic metal Inorganic materials 0.000 description 1
- 150000003818 basic metals Chemical class 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 150000003936 benzamides Chemical class 0.000 description 1
- MXMZCLLIUQEKSN-UHFFFAOYSA-N benzimidazoline Chemical compound C1=CC=C2NCNC2=C1 MXMZCLLIUQEKSN-UHFFFAOYSA-N 0.000 description 1
- BNBQRQQYDMDJAH-UHFFFAOYSA-N benzodioxan Chemical compound C1=CC=C2OCCOC2=C1 BNBQRQQYDMDJAH-UHFFFAOYSA-N 0.000 description 1
- 125000004618 benzofuryl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 description 1
- 125000004619 benzopyranyl group Chemical group O1C(C=CC2=C1C=CC=C2)* 0.000 description 1
- 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 description 1
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 description 1
- QRUDEWIWKLJBPS-UHFFFAOYSA-N benzotriazole Chemical compound C1=CC=C2N[N][N]C2=C1 QRUDEWIWKLJBPS-UHFFFAOYSA-N 0.000 description 1
- 239000012964 benzotriazole Substances 0.000 description 1
- 125000004541 benzoxazolyl group Chemical group O1C(=NC2=C1C=CC=C2)* 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 229910052796 boron Inorganic materials 0.000 description 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 125000004369 butenyl group Chemical group C(=CCC)* 0.000 description 1
- 125000000480 butynyl group Chemical group [*]C#CC([H])([H])C([H])([H])[H] 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 244000309466 calf Species 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 208000003295 carpal tunnel syndrome Diseases 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 206010007821 cauda equina syndrome Diseases 0.000 description 1
- 230000005779 cell damage Effects 0.000 description 1
- 208000037887 cell injury Diseases 0.000 description 1
- 230000002490 cerebral effect Effects 0.000 description 1
- 208000036319 cervical spondylosis Diseases 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- IJOOHPMOJXWVHK-UHFFFAOYSA-N chlorotrimethylsilane Chemical compound C[Si](C)(C)Cl IJOOHPMOJXWVHK-UHFFFAOYSA-N 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 201000003139 chronic cystitis Diseases 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 208000013507 chronic prostatitis Diseases 0.000 description 1
- 125000000259 cinnolinyl group Chemical class N1=NC(=CC2=CC=CC=C12)* 0.000 description 1
- 208000014439 complex regional pain syndrome type 2 Diseases 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 125000000596 cyclohexenyl group Chemical group C1(=CCCCC1)* 0.000 description 1
- GCUVBACNBHGZRS-UHFFFAOYSA-N cyclopenta-1,3-diene cyclopenta-2,4-dien-1-yl(diphenyl)phosphane iron(2+) Chemical compound [Fe++].c1cc[cH-]c1.c1cc[c-](c1)P(c1ccccc1)c1ccccc1 GCUVBACNBHGZRS-UHFFFAOYSA-N 0.000 description 1
- 125000002433 cyclopentenyl group Chemical group C1(=CCCC1)* 0.000 description 1
- 238000013016 damping Methods 0.000 description 1
- 230000000593 degrading effect Effects 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 238000010511 deprotection reaction Methods 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- LCSNDSFWVKMJCT-UHFFFAOYSA-N dicyclohexyl-(2-phenylphenyl)phosphane Chemical group C1CCCCC1P(C=1C(=CC=CC=1)C=1C=CC=CC=1)C1CCCCC1 LCSNDSFWVKMJCT-UHFFFAOYSA-N 0.000 description 1
- 125000005051 dihydropyrazinyl group Chemical group N1(CC=NC=C1)* 0.000 description 1
- IQDGSYLLQPDQDV-UHFFFAOYSA-N dimethylazanium;chloride Chemical compound Cl.CNC IQDGSYLLQPDQDV-UHFFFAOYSA-N 0.000 description 1
- OBISXEJSEGNNKL-UHFFFAOYSA-N dinitrogen-n-sulfide Chemical compound [N-]=[N+]=S OBISXEJSEGNNKL-UHFFFAOYSA-N 0.000 description 1
- KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical compound [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- CNXMDTWQWLGCPE-UHFFFAOYSA-N ditert-butyl-(2-phenylphenyl)phosphane Chemical group CC(C)(C)P(C(C)(C)C)C1=CC=CC=C1C1=CC=CC=C1 CNXMDTWQWLGCPE-UHFFFAOYSA-N 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 208000024732 dysthymic disease Diseases 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000006911 enzymatic reaction Methods 0.000 description 1
- NIMKIMUBJFWPTD-UHFFFAOYSA-N ethyl 5,5-dimethyl-2,4-dioxohexanoate Chemical compound CCOC(=O)C(=O)CC(=O)C(C)(C)C NIMKIMUBJFWPTD-UHFFFAOYSA-N 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 235000019253 formic acid Nutrition 0.000 description 1
- 239000001530 fumaric acid Substances 0.000 description 1
- 125000002541 furyl group Chemical group 0.000 description 1
- 238000007429 general method Methods 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 125000003187 heptyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000000623 heterocyclic group Chemical group 0.000 description 1
- 125000006038 hexenyl group Chemical group 0.000 description 1
- 125000003707 hexyloxy group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])O* 0.000 description 1
- 238000013537 high throughput screening Methods 0.000 description 1
- IKDUDTNKRLTJSI-UHFFFAOYSA-N hydrazine monohydrate Substances O.NN IKDUDTNKRLTJSI-UHFFFAOYSA-N 0.000 description 1
- 229910000042 hydrogen bromide Inorganic materials 0.000 description 1
- 125000005945 imidazopyridyl group Chemical group 0.000 description 1
- 125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 description 1
- 125000003454 indenyl group Chemical group C1(C=CC2=CC=CC=C12)* 0.000 description 1
- 125000003387 indolinyl group Chemical group N1(CCC2=CC=CC=C12)* 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 229950001891 iprotiazem Drugs 0.000 description 1
- 208000002551 irritable bowel syndrome Diseases 0.000 description 1
- 125000001261 isocyanato group Chemical group *N=C=O 0.000 description 1
- 125000005928 isopropyloxycarbonyl group Chemical group [H]C([H])([H])C([H])(OC(*)=O)C([H])([H])[H] 0.000 description 1
- 125000005956 isoquinolyl group Chemical group 0.000 description 1
- CTAPFRYPJLPFDF-UHFFFAOYSA-N isoxazole Chemical compound C=1C=NOC=1 CTAPFRYPJLPFDF-UHFFFAOYSA-N 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 238000011813 knockout mouse model Methods 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000010410 layer Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- UKVIEHSSVKSQBA-UHFFFAOYSA-N methane;palladium Chemical compound C.[Pd] UKVIEHSSVKSQBA-UHFFFAOYSA-N 0.000 description 1
- SPUACDWLOLSOQO-UHFFFAOYSA-M methoxyazanium;chloride Chemical compound [Cl-].CO[NH3+] SPUACDWLOLSOQO-UHFFFAOYSA-M 0.000 description 1
- 125000004184 methoxymethyl group Chemical group [H]C([H])([H])OC([H])([H])* 0.000 description 1
- YACCECLVHQLZQK-UHFFFAOYSA-N methoxyperoxyethane Chemical compound CCOOOC YACCECLVHQLZQK-UHFFFAOYSA-N 0.000 description 1
- AQYAHPDSJAFBOS-UHFFFAOYSA-N methyl 2,4-dioxo-4-phenylbutanoate Chemical compound COC(=O)C(=O)CC(=O)C1=CC=CC=C1 AQYAHPDSJAFBOS-UHFFFAOYSA-N 0.000 description 1
- RSKKVNLCWKPWEI-UHFFFAOYSA-N methyl 4-(4-methoxyphenyl)-2,4-dioxobutanoate Chemical compound COC(=O)C(=O)CC(=O)C1=CC=C(OC)C=C1 RSKKVNLCWKPWEI-UHFFFAOYSA-N 0.000 description 1
- NQMRYBIKMRVZLB-UHFFFAOYSA-N methylamine hydrochloride Chemical compound [Cl-].[NH3+]C NQMRYBIKMRVZLB-UHFFFAOYSA-N 0.000 description 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 description 1
- 230000027939 micturition Effects 0.000 description 1
- 206010027599 migraine Diseases 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 125000002757 morpholinyl group Chemical group 0.000 description 1
- 201000006417 multiple sclerosis Diseases 0.000 description 1
- 125000003136 n-heptyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 210000003928 nasal cavity Anatomy 0.000 description 1
- 201000001119 neuropathy Diseases 0.000 description 1
- 230000007823 neuropathy Effects 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 150000002825 nitriles Chemical class 0.000 description 1
- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
- 125000001400 nonyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000002868 norbornyl group Chemical group C12(CCC(CC1)C2)* 0.000 description 1
- 230000001473 noxious effect Effects 0.000 description 1
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 150000007530 organic bases Chemical class 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 201000008482 osteoarthritis Diseases 0.000 description 1
- 235000006408 oxalic acid Nutrition 0.000 description 1
- 125000005880 oxathiolanyl group Chemical group 0.000 description 1
- 125000005968 oxazolinyl group Chemical group 0.000 description 1
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 description 1
- 125000001037 p-tolyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])[H] 0.000 description 1
- 230000008058 pain sensation Effects 0.000 description 1
- PIBWKRNGBLPSSY-UHFFFAOYSA-L palladium(II) chloride Chemical compound Cl[Pd]Cl PIBWKRNGBLPSSY-UHFFFAOYSA-L 0.000 description 1
- 125000002255 pentenyl group Chemical group C(=CCCC)* 0.000 description 1
- 125000005981 pentynyl group Chemical group 0.000 description 1
- 208000033808 peripheral neuropathy Diseases 0.000 description 1
- 238000001050 pharmacotherapy Methods 0.000 description 1
- 125000005561 phenanthryl group Chemical group 0.000 description 1
- XYFCBTPGUUZFHI-UHFFFAOYSA-N phosphine group Chemical group P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 description 1
- 230000026731 phosphorylation Effects 0.000 description 1
- 238000006366 phosphorylation reaction Methods 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 125000004193 piperazinyl group Chemical group 0.000 description 1
- 125000005936 piperidyl group Chemical group 0.000 description 1
- 229920001992 poloxamer 407 Polymers 0.000 description 1
- 125000003367 polycyclic group Chemical group 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 125000004368 propenyl group Chemical group C(=CC)* 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000004742 propyloxycarbonyl group Chemical group 0.000 description 1
- 210000002307 prostate Anatomy 0.000 description 1
- 125000006239 protecting group Chemical group 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000001107 psychogenic effect Effects 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- QFYXSLAAXZTRLG-UHFFFAOYSA-N pyrrolidine-2,3-dione Chemical class O=C1CCNC1=O QFYXSLAAXZTRLG-UHFFFAOYSA-N 0.000 description 1
- 125000002112 pyrrolidino group Chemical group [*]N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
- 125000002294 quinazolinyl group Chemical group N1=C(N=CC2=CC=CC=C12)* 0.000 description 1
- 125000001567 quinoxalinyl group Chemical group N1=C(C=NC2=CC=CC=C12)* 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
- 210000000664 rectum Anatomy 0.000 description 1
- 230000011514 reflex Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 210000001044 sensory neuron Anatomy 0.000 description 1
- 230000020341 sensory perception of pain Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 230000019491 signal transduction Effects 0.000 description 1
- 239000012279 sodium borohydride Substances 0.000 description 1
- 229910000033 sodium borohydride Inorganic materials 0.000 description 1
- 235000009518 sodium iodide Nutrition 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 208000005801 spondylosis Diseases 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 230000036262 stenosis Effects 0.000 description 1
- 208000037804 stenosis Diseases 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 125000005415 substituted alkoxy group Chemical group 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 230000002889 sympathetic effect Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- ILMRJRBKQSSXGY-UHFFFAOYSA-N tert-butyl(dimethyl)silicon Chemical group C[Si](C)C(C)(C)C ILMRJRBKQSSXGY-UHFFFAOYSA-N 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 125000005886 tetrahydrobenzothienyl group Chemical group 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 125000005458 thianyl group Chemical group 0.000 description 1
- BRNULMACUQOKMR-UHFFFAOYSA-N thiomorpholine Chemical compound C1CSCCN1 BRNULMACUQOKMR-UHFFFAOYSA-N 0.000 description 1
- 125000004568 thiomorpholinyl group Chemical group 0.000 description 1
- 210000000115 thoracic cavity Anatomy 0.000 description 1
- 208000004371 toothache Diseases 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 230000000472 traumatic effect Effects 0.000 description 1
- 125000004306 triazinyl group Chemical group 0.000 description 1
- OVCXRBARSPBVMC-UHFFFAOYSA-N triazolopyridine Chemical compound C=1N2C(C(C)C)=NN=C2C=CC=1C=1OC=NC=1C1=CC=C(F)C=C1 OVCXRBARSPBVMC-UHFFFAOYSA-N 0.000 description 1
- 125000001425 triazolyl group Chemical group 0.000 description 1
- TUQOTMZNTHZOKS-UHFFFAOYSA-N tributylphosphine Chemical compound CCCCP(CCCC)CCCC TUQOTMZNTHZOKS-UHFFFAOYSA-N 0.000 description 1
- PIILXFBHQILWPS-UHFFFAOYSA-N tributyltin Chemical compound CCCC[Sn](CCCC)CCCC PIILXFBHQILWPS-UHFFFAOYSA-N 0.000 description 1
- ZMANZCXQSJIPKH-UHFFFAOYSA-O triethylammonium ion Chemical compound CC[NH+](CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-O 0.000 description 1
- 206010044652 trigeminal neuralgia Diseases 0.000 description 1
- GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical compound CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/38—2-Pyrrolones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
- A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Abstract
本发明提供式(I)表示的化合物:其中R1、R2、R3、Z1、Z2、Ra、Rb、q、A和n均如说明书所定义,其可药用的盐或溶剂合物。该化合物有用于作为P2X3和/或P2X2/3受体拮抗物。
Description
技术领域
[0001]
本发明涉及P2X受体,特别涉及有用于与P2X3受体特别是P2X3和/或P2X2/3受体相关的疾病或状况的治疗的化合物,以及包含该化合物的药物组合物。
背景技术
[0002]
已知ATP(腺苷三磷酸)作为细胞中的能量源和磷酸化基质,以及细胞外信使起作用。已知ATP由于多种刺激比如细胞损伤、炎症、伤害性刺激、血氧含量降低而自细胞释放,还已知其与来自初级感觉神经末梢的另一个信使一同释放。因而,释放至细胞外的ATP经由ATP受体介导多种细胞外信号转导(非专利文献6、非专利文献7)。
[0003]
ATP受体被分类为离子型P2X家族和G蛋白质偶联P2Y家族。对于P2X家族,已报道了7种亚型,且该家族的成员形成同型三聚结构或与该亚型的另外成员一同形成异型三聚结构,并起着非特异性阳离子通道的功能(非专利文献8)。
[0004]
已知ATP导致疼痛,并且使用P2X3敲除和敲落方法学研究表明,P2X3受体介导慢性疼痛的传输。P2X3受体以特异性方式表达于末梢感觉神经,以形成同型复合体或与P2X2形成异型复合体(P2X2/3)(非专利文献1)。
[0005]
之后,化合物A-317491被报道作为P2X3和P2X2/3受体的特异性拮抗物。A-317491是三取代-N-[(1S)-1,2,3,4-四氢-1-萘基]苯甲酰胺衍生物,以下式表示:
[化学式1]
(专利文献1)。据报道,其显示对P2X3和P2X2/3受体的拮抗物活性以及在大鼠神经性疼痛模型和炎症性疼痛模型中的镇痛作用(非专利文献9)。这表明痛觉经由P2X3或P2X2/3受体传输,且P2X3或P2X2/3受体拮抗物作为镇痛剂有用。显示P2X3或P2X2/3受体拮抗作用的化合物还记载于专利文献2-7。
[0006]
另外,最近报道在P2X3敲除小鼠中,膀胱反射显著减少(非专利文献2),暗示P2X3拮抗物在膀胱过度活动所引发疾病的治疗中有用。
[0007]
非专利文献3和4公开了具有与本发明所述化合物相似结构的化合物显示镇痛活性。然而,这些化合物的结构不同于本发明所述化合物。
[0008]
[专利文献1]WO02/094767
[专利文献2]WO2005/095359
[专利文献3]US20070037974
[专利文献4]US20070049758
[专利文献5]US20070049610
[专利文献6]US20070049609
[专利文献7]US20070049534
[非专利文献1]Neuroscientist 11(2005)pp.345-356
[非专利文献2]J.Physiol.567.2(2005)pp.621-639
[非专利文献3]Pharmaceutical Chemistry Journal Vol.39,No.9,(2005),pp484-487
[非专利文献4]Pharmaceutical Chemistry Journal Vol.31,No.5,(1997),pp251-254
[非专利文献5]Expert Opin.Ther.Patens(2006)16(8)113-1127.
[非专利文献6]J.Physiology(2003),554(2),301-308
[非专利文献7]J.Physiology(2003),553(3),683-694
[非专利文献8]Pflungers Arch Eur J physiol(2006),452,513-537
[非专利文献9]PNAS(2002),99(26),17179-17184
发明内容
本发明要解决的问题
[0009]
本发明提供新型P2X3和/或P2X2/3受体拮抗物。
解决问题的方法
[0010]
在解决上述问题的研究过程中,本发明人发现了特异性结合至P2X3和/或P2X2/3受体,并显示拮抗作用的新型化合物,从而实现了下述发明。
[1]P2X3和/或P2X2/3受体拮抗物,其包含式(I)的化合物或其可药用的盐或溶剂合物,所述式(I)为:
[化学式2]
其中
Z1为任选地被保护的羟基,任选地被保护的羟氨基或任选地被取代的氨基;
Z2为=O或=N-E,其中E为氢、羟基、任选地被取代的低级烷基、任选地被取代的低级烷氧基或任选地被取代的氨基,或者
[化学式3]
其中R4和R5独立地为氢或低级烷基,R6为氢、任选地被取代的低级烷基或酰基,r为0-2的整数;
A为环烷基、环烯基、芳基或杂环基;
Ra和Rb独立地为氢或低级烷基;
q为0-4的整数;
各R1独立地为卤素、羟基、任选地被取代的低级烷基、任选地被取代的低级链烯基、任选地被取代的低级炔基、任选地被取代的低级烷氧基、任选地被取代的低级烷硫基、任选地被取代的酰基、羧基、任选地被取代的低级烷氧基羰基、任选地被取代的氨甲酰基、任选地被取代的低级烷基氨甲酰基、任选地被取代的氨基、任选地被取代的氨磺酰基、氰基、硝基、任选地被取代的环烷基、任选地被取代的环烯基、任选地被取代的芳基或任选地被取代的杂环基;
n为0-3的整数,
前提是:
[化学式4]
R2为任选地被取代的烷基、任选地被取代的低级烷氧基、任选地被取代的低级烷基氨甲酰基、任选地被取代的环烷基、任选地被取代的环烯基、任选地被取代的芳基或任选地被取代的杂环基;
R3为氢,任选地被取代的烷基、任选地被取代的环烷基、任选地被取代的环烯基、任选地被取代的芳基或任选地被取代的杂环基。
[2]根据[1]所述的P2X3和/或P2X2/3受体拮抗物,其中Z1为羟基且Z2为=O。
[3]根据[1]所述的P2X3和/或P2X2/3受体拮抗物,其中r为0。
[4]根据[1]-[3]中任一项所述的P2X3和/或P2X2/3受体拮抗物,其中A为苯基、吡啶基或噻唑基。
[5]根据[1]-[4]中任一项所述的P2X3和/或P2X2/3受体拮抗物,其中R1为任选地被取代的低级烷氧基羰基或任选地被取代的杂环基。
[6]根据[1]-[5]中任一项所述的P2X3和/或P2X2/3受体拮抗物,其中R2为任选地被取代的低级烷基、任选地被取代的苯基或任选地被取代的吡啶基。
[7]根据[1]-[6]中任一项所述的P2X3和/或P2X2/3受体拮抗物,其中R3为具有3-10个碳原子的烷基、环烷基或任选地被取代的苯基。
[8]根据[1]-[7]中任一项所述的P2X3和/或P2X2/3受体拮抗物,其中q为0。
[9]根据[1]-[7]中任一项所述的P2X3和/或P2X2/3受体拮抗物,其中q为1。
[10]式(I′)的化合物或其可药用的盐或溶剂合物:
[化学式5]
其中
Z1为任选地被保护的羟基、任选地被保护的羟氨基或任选地被取代的氨基;Z2为=O或=N-E,其中E为氢、羟基、任选地被取代的低级烷基、任选地被取代的低级烷氧基或任选地被取代的氨基,或者
[化学式6]
其中R4和R5独立地为氢或低级烷基,R6为氢、任选地被取代的低级烷基或酰基、r为0-2的整数;
A和B独立地为环烷基、环烯基、芳基或杂环基;
R1a和R1b独立地为卤素、羟基、任选地被取代的低级烷基、任选地被取代的低级链烯基、任选地被取代的低级炔基、任选地被取代的低级烷氧基、任选地被取代的低级烷硫基、任选地被取代的酰基、羧基、任选地被取代的低级烷氧基羰基、任选地被取代的氨甲酰基、任选地被取代的低级烷基氨甲酰基、任选地被取代的氨基、任选地被取代的氨磺酰基、氰基或硝基;
m和p独立地为0-2的整数;
R2为任选地被取代的烷基、任选地被取代的低级烷氧基、任选地被取代的低级烷基氨甲酰基、任选地被取代的环烷基、任选地被取代的环烯基、任选地被取代的芳基或任选地被取代的杂环基;
R3为氢,任选地被取代的低级烷基、任选地被取代的环烷基、任选地被取代的环烯基、任选地被取代的芳基或任选地被取代的杂环基;
前提是:A为吡唑啉酮且B为苯基的化合物除外。
[11]根据[10]所述的化合物或其可药用的盐或溶剂合物,其中Z1为任选地被保护的羟基;Z2为=O;R2为任选地被取代的烷基、任选地被取代的低级烷氧基、任选地被取代的环烷基、任选地被取代的环烯基、任选地被取代的芳基或任选地被取代的杂环基。
[12]根据[10]所述的化合物或其可药用的盐或溶剂合物,其中r为0,R2为任选地被取代的烷基、任选地被取代的低级烷氧基、任选地被取代的环烷基、任选地被取代的环烯基、任选地被取代的芳基或任选地被取代的杂环基。
[13]根据[9]-[12]中任一项所述的化合物或其可药用的盐或溶剂合物,其中A为苯基、吡啶基或噻唑基。
[14]式(I″)的化合物或其可药用的盐或溶剂合物:
[化学式7]
其中
Z1为任选地被保护的羟基、任选地被保护的羟氨基或任选地被取代的氨基;Z2为=O或=N-E,其中E为氢、羟基、任选地被取代的低级烷基、任选地被取代的低级烷氧基或任选地被取代的氨基,或者
[化学式8]
其中R4和R5独立地为氢或低级烷基,R6为氢、任选地被取代的低级烷基或酰基、r为0-2的整数;
A为环烷基、环烯基、芳基或杂环基;
各R1a独立地为卤素、羟基、任选地被取代的低级烷基、任选地被取代的低级烷氧基、任选地被取代的低级烷硫基、任选地被取代的酰基、羧基、任选地被取代的低级烷氧基羰基、任选地被取代的氨甲酰基、任选地被取代的低级烷基氨甲酰基、任选地被取代的氨基、任选地被取代的氨磺酰基、氰基或硝基;
m为0-2的整数;
R1c和R1d独立地为氢或任选地被取代的低级烷基;
R2为任选地被取代的烷基、任选地被取代的低级烷氧基、任选地被取代的低级烷基氨甲酰基、任选地被取代的环烷基、任选地被取代的环烯基、任选地被取代的芳基或任选地被取代的杂环基;
R3为氢,任选地被取代的低级烷基、任选地被取代的环烷基、任选地被取代的环烯基、任选地被取代的芳基或任选地被取代的杂环基。
[15]根据[14]所述的化合物或其可药用的盐或溶剂合物,其中Z1为任选地被保护的羟基;Z2为=O;R2为任选地被取代的烷基、任选地被取代的低级烷氧基、任选地被取代的环烷基、任选地被取代的环烯基、任选地被取代的芳基或任选地被取代的杂环基。
[16]根据[14]所述的化合物或其可药用的盐或溶剂合物,其中r为0;R2为任选地被取代的烷基、任选地被取代的低级烷氧基、任选地被取代的环烷基、任选地被取代的环烯基、任选地被取代的芳基或任选地被取代的杂环基。
[17]根据[14]-[16]中任一项所述的化合物或其可药用的盐或溶剂合物,其中A为苯基、吡啶基或噻唑基。
[18]药物组合物,其包含根据[10]-[17]中任一项所述的化合物或其可药用的盐或溶剂合物。
[19]P2X3和/或P2X2/3受体拮抗物,其包含根据[10]-[17]中任一项所述的化合物或其可药用的盐或溶剂合物。
[20]根据[10]-[17]中任一项所述的化合物或其可药用的盐或溶剂合物的用途,其用于与P2X3和/或P2X2/3受体相关的疾病的治疗和/或预防。
[21]与P2X3和/或P2X2/3受体相关的疾病的治疗和/或预防用方法,其包括施用根据[10]-[17]中任一项所述的化合物或其可药用的盐或溶剂合物。
[0011]
在另一个实施方案中,本发明被如下提供。
[1′]P2X3或P2X2/3受体拮抗物,其包含式(I)的化合物或其可药用的盐或溶剂合物,所述式(I)为:
[化学式9]
其中
Z1为任选地被保护的羟基,任选地被保护的羟氨基或任选地被取代的氨基;
Z2为O或NOH,或者
[化学式10]
其中R4和R5独立地为氢或低级烷基,R6为氢、低级烷基或酰基,r为0-2的整数;
A为环烷基、环烯基、芳基或杂环基;
Ra和Rb独立地为氢或低级烷基;
q为0或1;
各R1独立地为卤素、羟基、任选地被取代的低级烷基、任选地被取代的低级烷氧基、任选地被取代的低级烷硫基、任选地被取代的酰基、羧基、任选地被取代的低级烷氧基羰基、任选地被取代的氨甲酰基、任选地被取代的低级烷基氨甲酰基、任选地被取代的氨基、任选地被取代的氨磺酰基、氰基、硝基、任选地被取代的环烷基、任选地被取代的环烯基、任选地被取代的芳基或任选地被取代的杂环基;
n为0-3的整数;
前提是:
[化学式11]
R2为任选地被取代的低级烷基、任选地被取代的环烷基、任选地被取代的环烯基、任选地被取代的芳基或任选地被取代的杂环基;
R3为氢、任选地被取代的烷基、任选地被取代的环烷基、任选地被取代的环烯基、任选地被取代的芳基或任选地被取代的杂环基。
[2′]根据[1′]的P2X3或P2X2/3受体拮抗物,其中Z1为羟基且Z2为O。
[3′]根据[1′]或[2′]的P2X3或P2X2/3受体拮抗物,其中A为苯基。
[4′]根据[1′]-[3′]中任一项的P2X3或P2X2/3受体拮抗物,其中R1为任选地被取代的低级烷氧基羰基或任选地被取代的杂环基。
[5′]根据[1′]-[4′]中任一项的P2X3或P2X2/3受体拮抗物,其中R2为任选地被取代的苯基或任选地被取代的吡啶基。
[6′]根据[1′]-[5′]中任一项的P2X3或P2X2/3受体拮抗物,其中R3为具有3-10个碳原子的烷基、环烷基或任选地被取代的苯基。
[7′]根据[1′]-[6′]中任一项的P2X3或P2X2/3受体拮抗物,其中q为0。
[8′]式(I′)的化合物或其可药用的盐或溶剂合物:
[化学式12]
其中
Z1为任选地被保护的羟基,任选地被保护的羟氨基或任选地被取代的氨基;Z2为O或NOH,或者
[化学式13]
其中R4和R5独立地为氢或低级烷基,R6为氢、低级烷基或酰基,r为0-2的整数;
A和B独立地为环烷基、环烯基、芳基或杂环基;
R1a和R1b独立地为卤素、羟基、任选地被取代的低级烷基、任选地被取代的低级烷氧基、任选地被取代的低级烷硫基、任选地被取代的酰基、羧基、任选地被取代的低级烷氧基羰基、任选地被取代的氨甲酰基、任选地被取代的低级烷基氨甲酰基、任选地被取代的氨基、任选地被取代的氨磺酰基、氰基或硝基;
m和p独立地为0-2的整数;
R2为任选地被取代的低级烷基、任选地被取代的环烷基、任选地被取代的环烯基、任选地被取代的芳基或任选地被取代的杂环基;
R3为任选地被取代的低级烷基、任选地被取代的环烷基、任选地被取代的环烯基、任选地被取代的芳基或任选地被取代的杂环基;
前提是:A为吡唑啉酮且B为苯基的化合物除外。
[9′]根据[8′]所述的化合物或其可药用的盐或溶剂合物,其中Z1为任选地被保护的羟基;Z2为O;R2为任选地被取代的环烷基、任选地被取代的环烯基、任选地被取代的芳基或任选地被取代的杂环基。
[10′]式(I″)的化合物或其可药用的盐或溶剂合物:
[化学式14]
其中
Z1为任选地被保护的羟基,任选地被保护的羟氨基或任选地被取代的氨基:
Z2为O或NOH,或者
[化学式15]
其中R4和R5独立地为氢或低级烷基,R6为氢、低级烷基或酰基、r为0-2的整数;
A为环烷基、环烯基、芳基或杂环基;
各R1a独立地为卤素、羟基、任选地被取代的低级烷基、任选地被取代的低级烷氧基、任选地被取代的低级烷硫基、任选地被取代的酰基、羧基、任选地被取代的低级烷氧基羰基、任选地被取代的氨甲酰基、任选地被取代的低级烷基氨甲酰基、任选地被取代的氨基、任选地被取代的氨磺酰基、氰基或硝基;
m为0-2的整数;
R1c和R1d独立地为氢或任选地被取代的低级烷基;
R2为任选地被取代的低级烷基、任选地被取代的环烷基、任选地被取代的环烯基、任选地被取代的芳基或任选地被取代的杂环基;
R3为任选地被取代的低级烷基、任选地被取代的环烷基、任选地被取代的环烯基、任选地被取代的芳基或任选地被取代的杂环基。
[11′]药物组合物,其包含根据[8′]-[10′]中任一项所述的化合物或其可药用的盐或溶剂合物。
[12′]P2X3和/或P2X2/3受体拮抗物,其包含根据[8′]-[10′]中任一项所述的化合物或其可药用的盐或溶剂合物。
[13′]根据[1′]-[7′]中任一项所述的P2X3或P2X2/3受体拮抗物,其是镇痛剂。
[14′]镇痛剂,其包含根据[8′]-[10′]中任一项所述的化合物或其可药用的盐或溶剂合物。
[15′]镇痛方法,其包括施用根据[1′]-[10′]中任一项所述的化合物或其可药用的盐或溶剂合物。
[16′]根据[1′]-[10′]中任一项所述的化合物或其可药用的盐或溶剂合物的用途,其用于制造镇痛剂。
具体实施方式
[0012]
本发明所述的化合物具有下述特征结构:
1)其具有吡咯啉-2-酮环作为基础骨架;和
2-1)其在所述吡咯啉环的3位具有烯醇型羟基;或
2-2)其在所述吡咯啉环的3位和4位具有取代基以一起形成下式的含氮杂环:
[化学式16]
其中,R4、R5、R6和r如上述定义;和
3)其在所述吡咯啉环的1位氮上具有下式的取代基:
[化学式17]
其中,A、R1、Ra、Rb、n和q如上述定义,前提是:在上述(2-2)的情况下,吡咯啉环1位的氮可以无取代基;
3-1)其在所述吡咯啉环的1位氮上具有下式的取代基:
[化学式18]
其中A、B、R1a、R1b、m和p如上述定义;
3-2)其在所述吡咯啉环的1位氮上具有下式的取代基:
[化学式19]
其中,A、R1a、R1c、R1d和m如上述定义。
当上述式(I)、(I′)和(I″)中n、m和/或p为2以上的整数时,各R1、各R1a和/或各R1b彼此可相同或不同。
[0013]
以下说明本说明书中所使用的术语。除非特别指明,各术语具有下述意义。
[0014]
术语“烷基”意指含有1-10、优选1-8、更优选1-6个碳原子的直链或支链一价烃基,比如甲基、乙基、正丙基、异丙基、正丁基、异丁基、仲丁基、叔丁基、正戊基、异戊基、新戊基、正己基、异己基、正庚基、异庚基、正辛基、异辛基、正壬基和正癸基。
[0015]
术语“低级烷基”意指含有1-6、优选1-3个碳原子的直链或支链一价烃基,比如甲基、乙基、正丙基、异丙基、正丁基、异丁基、仲丁基、叔丁基、正戊基、异戊基、新戊基、正己基、异己基。
[0016]
术语“酰基”表示式R-CO-的基团,其中R为例如:如上述定义的“低级烷基”或如下述定义的“低级链烯基”、“芳基”、“杂环基”、“环烷基”或“环烯基”。
[0017]
术语“环烷基”意指含有3-10个碳原子的单环或多环饱和环碳链。单环环烷基包括,例如环丙基、环丁基、环戊基、环己基、环庚基、环辛基、环壬基、环癸基。多环环烷基包括降冰片烷基等。
[0018]
术语“环烯基”意指含有至少一个碳-碳双键的碳原子数3-10的非芳香族单环或多环环系统。单环环烯基包括环戊烯基、环已烯基等,多环环烯基包括降冰片基(norbornyl)等。
[0019]
术语“芳基”意指单环或稠环的芳烃,比如苯基、1-萘基、2-萘基、蒽基、菲基和茚基等。
[0020]
术语“杂环基”意指芳香族或非芳香族单环或稠环基团,其衍生自环内具有至少一个氮原子、氧原子和/或硫原子的5-7元环,由2个以上的所述5-7元环形成的稠环,由所述5-7元环与1个或多个如上定义的“芳基”、“环烷基”或“环烯基”稠合而形成的稠环。例如:非芳香族杂环基团比如吡咯啉基、1-吡咯烷基(pyrrolidino)、吡咯烷基、咪唑啉基(imidazolynyl)、咪唑烷基、吡唑啉基、吡唑烷基、1-哌啶基(piperidino)、(2-、3-或4-)哌啶基、1-哌嗪基、哌嗪基、(2-或3-)吗啉基、4-吗啉代、(2-或3-)硫代吗啉基、硫代吗啉代、四氢吡喃基、二氢吡啶基、二氢哒嗪基、二氢吡嗪基、二噁烷基、氧杂四氢噻吩基(oxathiolanyl)、噻吩基(thianyl)、四氢呋喃基、四氢吡喃基、四氢噻唑啉基、四氢异噻唑啉基等;
单环芳香族杂环基团比如吡咯基、吡嗪基、吡唑基、四唑基、呋喃基、噻吩基、吡啶基、咪唑啉基、三唑基、四唑基、三嗪基、哒嗪基、嘧啶基、吡嗪基、异噁唑基、噻唑基、异噻唑基、噻二唑基、噁唑基和噁二唑基等;以及
与其它环稠合的杂环基团,比如吲哚基、异吲哚基、吲唑基、吲哚嗪基(indolizinyl)、二氢吲哚基、异二氢吲哚基、喹啉基、异喹啉基、噌啉基、2,3-二氮杂萘基、喹唑啉基、1,5-二氮杂萘基、喹喔啉基、嘌呤基、蝶啶基、苯并吡喃基、苯并咪唑基、苯并异噁唑基、苯并噁唑基、苯并噁二唑基、苯并异噻唑基、苯并噻唑基、苯并噻二唑基、苯并呋喃基、异苯并呋喃基、苯并噻吩基、苯并三唑基、咪唑并吡啶基、三唑并吡啶基、咪唑并噻唑基、吡嗪并哒嗪基、苯并咪唑啉基、苯并二噁烷基、四氢喹啉、四氢苯并噻吩基等。
[0021]
术语“卤素”意指氟、氯、溴和碘。
[0022]
术语“低级烷氧基”意指式RO-的基团,其中R为如上对低级烷基的定义,比如甲氧基、乙氧基、丙氧基、异丙氧基、丁氧基、异丁氧基、仲丁氧基、叔丁氧基、戊氧基、异戊氧基、新戊氧基、己氧基等。
[0023]
术语“低级烷硫基”意指式RS-的基团,其中R为如上对于低级烷基的定义,比如甲硫基、乙硫基、丙硫基、异丙硫基、丁硫基、异丁硫基、仲丁硫基、叔丁硫基、戊硫基、异戊硫基、新戊硫基、己硫基等。
[0024]
术语“低级烷氧基羰基”意指式ROCO-的基团,其中R为如上对于低级烷基的定义,比如甲氧基羰基、乙氧基羰基、正丙氧基羰基、异丙氧基羰基、正丁氧基羰基、叔丁氧基羰基、正戊氧基羰基等。
[0025]
术语“低级烷基氨甲酰基”包括烷基部分含有1-6个碳原子的单或双低级烷基氨甲酰基,比如甲基氨甲酰基、乙基氨甲酰基、正丙基氨甲酰基、异丙基氨甲酰基、正丁基氨甲酰基、二甲基氨甲酰基、二乙基氨甲酰基、二丙基氨甲酰基等。
[0026]
用于“任选地被取代的低级烷基”、“任选地被取代的低级链烯基”、“任选地被取代的低级炔基”、“任选地被取代的低级烷氧基”、“任选地被取代的低级烷硫基”、“任选地被取代的低级烷氧基羰基”和“任选地被取代的低级烷基氨甲酰基”的取代基,包括但不限定于选自下述的一个或多个相同或不同的取代基:
羟基、羧基、卤素(F、Cl、Br、I)、卤代(低级)烷氧基(例如:CF3O)、环烷基(例如:环丙基)、环烯基(例如:环丙烯基)、低级烷氧基(例如:甲氧基、乙氧基、丙氧基、丁氧基等)、低级链烯基氧基(例如:乙烯基氧基、烯丙基氧基等)、低级烷氧基羰基(例如:甲氧基羰基、乙氧基羰基、叔丁氧基羰基等)、硝基、亚硝基、氨基、低级烷基氨基(例如:甲基氨基、乙基氨基、二甲基氨基等)、酰氨基(例如:乙酰氨基、苯甲酰氨基等)、芳烷基氨基(例如:苯甲基氨基、三苯甲基氨基)、羟氨基、亚氨基、羟亚氨基、低级烷基亚氨基(例如:甲基亚氨基、乙基亚氨基、二甲基亚氨基等)、低级烷氧基亚氨基(例如:甲氧基亚氨基、乙氧基亚氨基等)、酰亚氨基(例如:乙酰亚氨基、苯甲酰亚氨基等)、叠氮基、芳基(例如:苯基等)、芳烷基(例如:苯甲基等)、芳烷氧基(例如:苯甲氧基)、氰基、异氰基、异氰酰基(isocyanato)、硫氰酰基、异硫氰酰基、巯基、低级烷硫基(例如:甲硫基等)、低级烷基磺酰基(例如:甲基磺酰基、乙基磺酰基)、氨甲酰基、低级烷基氨甲酰基(例如:甲基氨甲酰基、乙基氨甲酰基、二甲基氨甲酰基等)、氨磺酰基、低级烷基氨磺酰基、酰基(例如:甲酰基、乙酰基等)、甲酰氧基、硫醛基、硫代羧基、二硫代羧基、硫代氨甲酰基、亚磺基、磺基、肼基、叠氮基、脲基、脒基、胍基、苯二酰亚氨基、三低级烷基甲硅烷基(例如:三甲基甲硅烷基等)、氧代以及下述实施例中记载的取代基。
[0027]
用于“任选地被取代的酰基”的取代基为如上述对于“任选地被取代的低级烷基”的定义。如果酰基(R-CO-)中的R为“芳基”、“杂环基”、“环烷基”或“环烯基”,则所述取代基可以为低级烷基(例如:甲基、乙基、异丙基、叔丁基等)、卤代(低级)烷基(例如:CF3、CH2CF3、CH2CCl3等)、低级链烯基、低级炔基(例如:乙炔基)等。
[0028]
用于“任选地被取代的氨甲酰基”和“任选地被取代的氨磺酰基”的取代基为,选自但不限定于下述的一种或多种相同或不同的基团:
羟基、羧基、卤素(F、Cl、Br、I)、低级链烯基(例如:乙烯基)、低级炔基(例如:乙炔基)、环烷基(例如:环丙基)、环烯基(例如:环丙烯基)、低级烷氧基羰基(例如:甲氧基羰基、乙氧基羰基、叔丁氧基羰基等)、氨基、低级烷基氨基(例如:甲基氨基、乙基氨基、二甲基氨基等)、酰氨基(例如:乙酰氨基、苯甲酰氨基等)、芳烷基氨基(例如:苯甲基氨基、三苯甲基氨基)、羟氨基、芳基(例如:苯基等)、氰基、异氰基、异氰酰基、硫氰酰基、异硫氰酰基、酰基(例如:甲酰基、乙酰基等)以及下述实施例中记载的取代基。
[0029]
用于“任选地被取代的氨基”的取代基为选自但不限定于下述的一种或多种相同或不同的基团:
羟基、卤素(F、Cl、Br、I)、卤代(低级)烷基(例如:CF3、CH2CF3、CH2CCl3等)、羟基(低级)烷基(例如:羟乙基、-C(CH3)2CH2OH等)、卤代(低级)烷氧基(例如:CF3O)、低级烷基(例如:甲基、乙基、异丙基、叔丁基等)、低级链烯基(例如:乙烯基)、低级炔基(例如:乙炔基)、环烷基(例如:环丙基)、环烯基(例如:环丙烯基)、低级烷氧基(例如:甲氧基、乙氧基、丙氧基、丁氧基等)、低级烷氧基羰基(叔丁氧基羰基等)、低级链烯基氧基(例如:乙烯基氧基、烯丙基氧基等)、氨基、低级烷基氨基(例如:甲基氨基、乙基氨基、二甲基氨基等)、酰氨基(例如:乙酰氨基、苯甲酰氨基等)、芳烷基氨基(例如:苯甲基氨基、三苯甲基氨基)、羟氨基、亚氨基、羟亚氨基、低级烷基亚氨基(例如:甲基亚氨基、乙基亚氨基、二甲基亚氨基等)、低级烷氧基亚氨基(例如:甲氧基亚氨基、乙氧基亚氨基等)、酰亚氨基(例如:乙酰亚氨基、苯甲酰亚氨基等)、芳基(例如:苯基等)、芳烷基(例如:苯甲基等)、氰基、酰基(例如甲酰基、乙酰基等)以及下述实施例中记载的取代基。
[0030]
用于“任选地被取代的环烷基”、“任选地被取代的环烯基”、“任选地被取代的芳基”、“任选地被取代的杂环基”、“任选地被取代的苯基”和“任选地被取代的吡啶基”的取代基为选自但不限定于下述的一种或多种相同或不同的基团:
羟基、羧基、卤素(F、Cl、Br、I)、卤代(低级)烷基(例如:CF3、CH2CF3、CH2CCl3等)、卤代(低级)烷氧基(CF3O)、低级烷基(例如:甲基、乙基、异丙基、叔丁基等)、低级链烯基(例如:乙烯基)、低级炔基(例如:乙炔基)、环烷基(例如:环丙基)、环烯基(例如:环丙烯基)、低级烷氧基(例如:甲氧基、乙氧基、丙氧基、丁氧基等)、低级链烯基氧基(例如:乙烯基氧基、烯丙基氧基等)、低级烷氧基羰基(例如:甲氧基羰基、乙氧基羰基、叔丁氧基羰基等)、硝基、亚硝基、氨基、低级烷基氨基(例如:甲基氨基、乙基氨基、二甲基氨基等)、酰氨基(例如:乙酰氨基、苯甲酰氨基等)、芳烷基氨基(例如:苯甲基氨基、三苯甲基氨基)、羟氨基、亚氨基、羟亚氨基、低级烷基亚氨基(例如:甲基亚氨基、乙基亚氨基、二甲基亚氨基等)、低级烷氧基亚氨基(例如:甲氧基亚氨基、乙氧基亚氨基等)、酰亚氨基(例如:乙酰亚氨基、苯甲酰亚氨基等)、叠氮基、芳基(例如:苯基等)、芳烷基(例如:苯甲基等)、芳烷氧基(例如:苯甲氧基等)、氰基、异氰基、异氰酰基、硫氰酰基、异硫氰酰基、巯基、低级烷硫基(例如:甲硫基等)、低级烷基磺酰基(例如:甲基磺酰基、乙基磺酰基)、任选地被取代的氨甲酰基(例如:氨甲酰基、N-甲基-N-甲氧基氨甲酰基等)、任选地被取代的低级烷基氨甲酰基(例如:甲基氨甲酰基、乙基氨甲酰基、二甲基氨甲酰基、羟基乙基氨甲酰基、三氟甲基氨甲酰基、三氟乙基氨甲酰基等)、氨磺酰基、低级烷基氨磺酰基、酰基(例如:甲酰基、乙酰基等)、甲酰氧基、硫醛基、硫代羧基、二硫代羧基、硫代氨甲酰基、亚磺基、磺基、肼基、叠氮基、脲基、脒基、胍基、苯二酰亚氨基、氧代以及下述实施例中记载的取代基。
[0031]
所述“卤代(低级)烷基”和“卤代(低级)烷氧基”中的卤素部分如上述对于“卤素”的定义。
[0032]
所述“卤代(低级)烷基”、“低级烷基氨基”、“低级烷基亚氨基”、“低级烷基磺酰基”、“低级烷基氨磺酰基”、“低级烷基氨甲酰基”、“芳烷基”和“芳烷基氨基”中的烷基或低级烷基部分为如上述对于“低级烷基”的定义。
[0033]
所述“卤代(低级)烷氧基”和“低级烷氧基亚氨基”中的低级烷氧基部分如上述对于“低级烷氧基”的定义。
[0034]
术语“低级链烯基”包括在任意位置上具有一个或多个双键的含有2-6个碳原子,优选含有2-3个碳原子的直链或支链链烯基,具体包括乙烯基、丙烯基、异丙烯基、丁烯基、异丁烯基、异戊二烯基(prenyl)、丁二烯基、戊烯基、异戊烯基、戊二烯基、己烯基、异己烯基和己二烯基等。
[0035]
“低级链烯基氧基”的低级链烯基部分为如上对于“低级链烯基”的定义。
[0036]
术语“低级炔基”意指含有2-6个碳原子,优选含有2-3个碳原子的直链或支链炔基,具体包括乙炔基、丙炔基、丁炔基、戊炔基和己炔基等。它们在任意位置上具有一个或多个三键,且任选地具有双键。
[0037]
“芳烷基氨基”和“芳烷基”的芳基部分如上述对于“芳基”的定义。
[0038]
“酰基”、“酰氨基”和“酰亚氨基”的酰基部分为如上对于“酰基”的定义。
[0039]
用于“任选地被保护的羟基”和“任选地被保护的羟氨基”的保护基是本领域所熟知的,且包括例如形成醚和取代醚的基团,比如甲基、甲氧基甲基、叔丁氧基甲基、1-乙氧基乙基和苯甲基等;形成甲硅烷基醚的基团,比如三甲基甲硅烷基、三乙基甲硅烷基、叔丁基二甲基甲硅烷基和甲基二异丙基甲硅烷基;形成酯的基团,比如甲酸酯、乙酸酯和三氯乙酸酯等;形成碳酸酯的基团,比如甲基碳酸酯、2,2,2-三氯乙基碳酸酯和对硝基苯基碳酸酯等;形成磺酰基的基团,比如甲基磺酰基、对甲苯磺酰基等。
[0040]
本发明的化合物(I)、(I′)或(I″)的优选实施方案包括:
Z1为羟基或羟氨基的化合物;
Z1为羟基的化合物;
Z2为O或NOH的化合物;
Z2为O的化合物;
[化学式20]
A为芳基或杂环基的化合物;
A为苯基的化合物;
R2为任选地被取代的芳基或任选地被取代的芳香族杂环基(例如:噻吩基、吡啶基、咪唑啉基、嘧啶基、异噁唑基、噻唑基、异噻唑基、噻二唑基、噁唑基、吡唑基和噁二唑基等)的化合物;
R2为任选地被取代的苯基的化合物;
R3为任选地被取代的烷基、任选地被取代的环烷基、任选地被取代的芳基或任选地被取代的杂环基的化合物;
R3为烷基、环烷基、任选地被取代的苯基或任选地被取代的芳香族杂环基(例如:噻吩基、吡啶基、咪唑啉基、嘧啶基、异噁唑基、噻唑基、异噻唑基、噻二唑基、噁唑基、吡唑基、噁二唑基、喹啉基等)的化合物;
R3为烷基、环烷基、任选地被取代的苯基的化合物。
[0041]
本发明的化合物(I)的优选实施方案包括:
q为0的化合物;
n为1或2;R1为卤素、任选地被取代的低级烷基、羧基、任选地被取代的低级烷氧基羰基、任选地被取代的芳基或任选地被取代的杂环基的化合物;
n为1或2;R1为任选地被取代的烷氧基羰基、任选地被取代的芳基或任选地被取代的杂环基的化合物;
n为1或2;R1为任选地被取代的低级烷氧基羰基、任选地被取代的苯基、任选地被取代的非芳香族杂环基(例如:二氧戊环基(dioxolanyl)、咪唑啉基、咪唑烷基、吡唑啉基、异噁唑啉基、噁唑啉基、噻唑啉基、异噻唑啉基等)、任选地被取代的芳香族杂环基(例如:噻吩基、吡啶基、咪唑基、嘧啶基、异噁唑基、噻唑基、异噻唑基、噻二唑基、噁唑基、吡唑基、噁二唑基等)。
[0042]
本发明的化合物(I′)的优选实施方案包括:
B为任选地被取代的非芳香族杂环基(例如:二氧戊环基、咪唑啉基、咪唑烷基、吡唑啉基、异噁唑啉基、噁唑啉基、噻唑啉基、异噻唑啉基等)、任选地被取代的芳香族杂环基(例如:噻吩基、吡啶基、咪唑基、嘧啶基、异噁唑基、噻唑基、异噻唑基、噻二唑基、噁唑基、吡唑基、噁二唑基等)的化合物;
m和p独立地为0或1,且R1a和R1b独立地为卤素、羟基、低级烷基或低级烷氧基的化合物。
[0043]
本发明的化合物(I″)的优选实施方案包括:
m为0或1,R1a为卤素、羟基、低级烷基或低级烷氧基的化合物;
R1c为氢、任选地被取代的低级烷基的化合物;
R1d为氢、任选地被取代的低级烷基的化合物;
R1c和R1d独立地为氢或任选地被取代的低级烷基的化合物。
[0044]
用于合成本发明化合物的一般方法如下所述。用于该合成中的起始物料和反应试剂为市售品或可使用市售品根据本领域所熟知的方法制备。
[0045]
本发明的化合物(I),即通式(I)的化合物(以其它式表示的化合物也可以按该方式提及),可以经由下述路径制备。
[路径1]
[化学式21]
其中,R7为低级烷基;所有其它符号如上述定义。
如所示,通式(Ia)的本发明的化合物,可以无溶剂地或在适当的溶剂中,在酸的存在或不存在下,通过化合物(II)、化合物(III)和化合物(IV)的反应而制备。
[0046]
在该反应中,化合物(III)和化合物(IV)相对于化合物(II)可以使用1当量或以上,优选1-3当量的量。
[0047]
可以使用的酸包括乙酸、对甲苯磺酸、盐酸等。
[0048]
可以使用的溶剂包括芳烃(例如:甲苯、苯、二甲苯等)、饱和烃(例如:环己烷、己烷等)、醚(例如:四氢呋喃、二乙醚、二噁烷等)和它们的混合溶剂。
[0049]
该反应的温度可以为-10℃~150℃,优选为20℃~100℃。反应时间取决于所述化合物,该反应可以施行10分钟~80小时。
[0050]
任选地,可以根据常规方法(例如:柱色谱、重结晶等)纯化由此获得的所需化合物(Ia)。
[0051]
[路径2]
[化学式22]
其中,所有符号如上述所定义。
如所示,通式(Ia)表示的本发明的化合物,可以无溶剂地或在适当的溶剂中,在酸的存在或不存在下,通过化合物(II)和化合物(V)的反应而制备。
[0052]
在该反应中,化合物(V)相对于化合物(II)可以使用1当量或以上,优选1-3当量的量。
[0053]
可以使用的酸包括乙酸、对甲苯磺酸、盐酸等。
[0054]
可以使用的溶剂包括芳烃(例如:甲苯、苯、二甲苯等)、饱和烃(例如:环己烷、己烷等)、醚(例如:四氢呋喃、二乙醚、二噁烷等)和它们的混合溶剂。
[0055]
该反应的温度可以为-10℃~150℃,优选为20℃~100℃。尽管反应时间取决于化合物,但该反应可以施行10分钟-80小时。
[0056]
任选地,可以根据常规方法(例如:柱色谱、重结晶等)纯化由此获得的所需化合物(Ia)。
[0057]
[路径3]
[化学式23]
其中,L和Q的一方为二羟基硼烷、二(低级)烷基硼烷或二(低级)烷氧基硼烷,且另一方为卤素或-OSO2(CsF2s+1),其中s为1-4的整数,且所有其它符号如上述定义。
[0058]
如所示,通式(Ib)所表示的本发明的化合物可以在合适的溶剂中,在钯催化剂和碱的存在下,通过化合物(VI)与化合物(VII)的铃木偶联反应(Suzuki coupling)而制备。
[0059]
在该反应中,化合物(VII)相对于化合物(VI)可以使用1当量或以上,优选1-3当量的量。
[0060]
可以使用的碱包括金属氢氧化物(例如:氢氧化钠、氢氧化钾等)、金属氢化物(例如:氢化钠、氢化锂等)、金属碳酸盐(例如:碳酸钠、碳酸钾、碳酸铯等)等。这些碱相对于化合物(VI)可以使用1当量或以上,优选1-5当量的量。
[0061]
可以使用的钯催化剂包括三(二亚苄基丙酮)二钯(0)、醋酸钯(II)、二氯双(三苯基膦)钯(II)或四(三苯基膦)钯(II)等,且相对于化合物(VI)可以使用0.001当量或以上,优选0.01-1当量的量。
[0062]
可以使用的溶剂包括芳烃(例如:甲苯、苯、二甲苯等)、饱和烃(例如:环己烷、己烷等)、醚(例如:四氢呋喃、二乙醚、二噁烷、二甲氧基乙烷等)、N,N-二甲基甲酰胺、水和它们的混合溶剂等。
[0063]
该反应的温度可以为-10℃~180℃,优选20℃~120℃,任选在微波辐射之下。尽管反应时间取决于化合物,但该反应可实施10分钟-80小时。
[0064]
任选地,可以根据常规方法(例如:柱色谱、重结晶等)纯化由此获得的所需化合物(Ib)。
[0065]
[路径4]
[化学式24]
其中,L和M的一方为三烷基锡(例如:-SnBu3等)且另一方为卤素或-OSO2(CsF2s+1),其中s为1-4的整数,且所有其它符号为如上述定义。
如所示,通式(Ib)表示的本发明的化合物可以在合适的溶剂中,在催化剂的存在下,通过化合物(VI)与化合物(VIII)的Stille偶联反应而制备。
[0066]
在该反应中,化合物(VIII)相对于化合物(VI)可以使用1当量或以上,优选1-3当量的量。
[0067]
可以使用的催化剂包括三(二亚苄基丙酮)二钯(0)、醋酸钯(II)、二氯双(三苯基膦)钯(II)或四(三苯基膦)钯(II)等,且相对于化合物(VI)可以使用0.001当量或以上、优选0.01-1当量的量。任选地,膦配体比如三叔丁基膦、2-(二叔丁基膦基)联苯、2-(双环己基膦基)联苯、三苯基膦、三(2-呋喃基)膦等可相对于所述催化剂添加两倍摩尔量。
[0068]
可以使用的溶剂包括芳烃(例如:甲苯、苯、二甲苯等)、饱和烃(例如:环己烷、己烷等)、醚(例如:四氢呋喃、二乙醚、二噁烷、二甲氧基乙烷等)、N,N-二甲基甲酰胺和它们的混合溶剂等。
[0069]
该反应的温度可以为-10℃~180℃,优选20℃~120℃,任选在微波辐射之下。尽管反应时间取决于化合物,但该反应可实施10分钟-80小时。
[0070]
任选地,可以根据常规方法(例如:柱色谱、重结晶等)纯化由此获得的所需化合物(Ib)。
[0071]
[路径5]
[化学式25]
其中,所有符号均如上述定义。
如所示,通式(X)表示的本发明的化合物可以在合适的溶剂中,在氧化剂的存在下,通过化合物(IX)的反应而制备。
[0072]
可以使用的氧化剂包括二氧化锰、2-碘酰苯甲酸等,且相对于化合物(IX)可以使用1当量或以上,优选1-1.5当量的量。
[0073]
可以使用的溶剂包括芳烃(例如:甲苯、苯、二甲苯等)、饱和烃(例如:环己烷、己烷等)、卤代烃(例如:二氯甲烷、1,2-二氯乙烷等)、醚(例如:四氢呋喃、二噁烷等)、酮(例如:丙酮、甲乙酮等)、腈(例如:乙腈等)和它们的混合溶剂等。
[0074]
该反应的温度可以为-10℃~150℃,优选为20℃~100℃。尽管反应时间取决于化合物,但该反应可以施行10分钟-80小时。
[0075]
所得的化合物(IX)可以作为粗制品或根据常规方法(例如:柱色谱、重结晶等)纯化后用于下一步骤。
[0076]
[路径5(续)]
[化学式26]
其中,t为0-3的整数;X1和X2独立地为NR8、O或S;R8为氢或低级烷基;所有其它符号为如上定义。
如所示,通式(Ic)表示的本发明的化合物可以无溶剂地或在适当的溶剂中,在酸的存在或不存在下,通过化合物(X)和化合物(XI)的反应而制备。
[0077]
在该反应中,化合物(XI)相对于化合物(X)可以使用1当量或以上,优选1-3当量的量。
[0078]
可以使用的酸包括对甲苯磺酸、硫酸、对甲苯磺酸吡啶鎓盐等。
[0079]
可以使用的溶剂包括芳烃(例如:甲苯、苯、二甲苯等)、饱和烃(例如:环己烷、己烷等)和它们的混合溶剂。
[0080]
该反应的温度可以为-10℃~170℃,优选为20℃~150℃。反应时间取决于化合物,该反应可以施行10分钟-80小时。
[0081]
任选地,可以根据常规方法(例如:柱色谱、重结晶等)纯化由此获得的所需化合物(Ic)。
[0082]
[路径6]
[化学式27]
其中,所有符号如上述所定义。
如所示,通式(Id)表示的本发明的化合物可以在合适的溶剂中,通过化合物(X)和化合物(XII)或其盐的反应而制备。所述化合物(XII)或其盐可以相对于化合物(X)使用1-4当量,优选1-2.5当量的量。
[0083]
化合物(XII)的盐包括无机酸盐比如盐酸盐、硫酸盐等。这些盐当其用于所述反应时用碱来中和。
[0084]
可以使用的碱包括乙酸钠、胺(吡啶等)等,且可相对于化合物(XI)的盐使用1-3当量,优选1-2当量的量。
[0085]
可以使用的溶剂包括芳烃(例如:苯、甲苯、二甲苯等)、卤代烃(例如:氯仿、1,2-二氯乙烷等)、醚(例如:四氢呋喃、二噁烷等)、醇(例如:甲醇、乙醇、正丙醇、异丙醇等)、水和它们的混合溶剂等。
[0086]
反应温度为0℃-150℃,优选20℃-120℃。
[0087]
反应时间通常为约10分钟-24小时。
[0088]
任选地,可以根据常规方法(例如:柱色谱、重结晶等)纯化由此获得的所需化合物(Id)。
[0089]
[路径7]
[化学式28]
其中,Hal为卤素;R9为羟基的保护基;所有其它符号均如上述定义。
如所示,通式(Ie)表示的本发明的化合物可以在合适的溶剂中,在碱的存在下,通过化合物(Ia)和化合物(XIII)的反应而制备。所述化合物(XII)可以相对于化合物(Ia)使用1-4当量,优选1-2.5当量的量。
[0090]
可以使用的碱包括胺等(三乙胺、吡啶等),且可相对于化合物(Ia)使用1-3当量,优选1-2当量的量。
[0091]
可以使用的溶剂包括芳烃(例如:苯、甲苯、二甲苯等)、卤代烃(例如:氯仿、1,2-二氯乙烷等)、醚(例如:四氢呋喃、二噁烷等)、N,N-二甲基甲酰胺、二甲亚砜和它们的混合溶剂等。
[0092]
反应温度为-20℃~150℃,优选0℃~120℃。
[0093]
反应时间通常为约10分钟-24小时。
[0094]
任选地,可以根据常规方法(例如:柱色谱、重结晶等)纯化由此获得的所需化合物(Ie)。
[0095]
[路径8]
[化学式29]
其中,所有符号均为如上定义。
如所示,通式(If)或(Ig)表示的本发明的化合物可以在合适的溶剂中,通过化合物(Ia)与胺或其盐的反应而制备。所述胺或其盐可以相对于化合物(Ia)使用1-4当量,优选1-2.5当量的量。
[0096]
羟胺的盐包括无机酸盐比如盐酸盐、硫酸盐等。这些盐当其用于所述反应时用碱来中和。
[0097]
可以使用的碱包括乙酸钠、胺等(吡啶等),且可相对于所述胺的盐使用1-3当量,优选1-2当量的量。
[0098]
可以使用的溶剂包括烃(例如:苯、甲苯、二甲苯等)、卤代烃(例如:氯仿、1,2-二氯乙烷等)、醚(例如:四氢呋喃、二噁烷等)、醇(例如:甲醇、乙醇、正丙醇、异丙醇等)、水和它们的混合溶剂等。
[0099]
反应温度为0℃-150℃,优选20℃-120℃。
[0100]
反应时间通常为15分钟-24小时。
[0101]
任选地,可以根据常规方法(例如:柱色谱法、重结晶等)纯化由此获得的所需化合物(If)或(Ig)。
[0102]
[路径9]
[化学式30]
其中,所有符号为如上述所定义。
如所示,通式(Ih)表示的本发明的化合物可以在合适的溶剂中通过化合物(Ia)和化合物(XIV)的反应而制备。所述化合物(XIV)可以相对于化合物(Ia)使用1-4当量,优选1-2.5当量的量。
[0103]
可以使用的溶剂包括乙酸、烃(例如:苯、甲苯、二甲苯等)、醚(例如:四氢呋喃、二噁烷等)、醇(例如:甲醇、乙醇、正丙醇、异丙醇等)和它们的混合溶剂等。
[0104]
反应温度为0℃-150℃,优选50℃-130℃。
[0105]
反应时间通常为约10分钟-24小时。
[0106]
任选地,可以根据常规方法(例如:柱色谱法、重结晶等)纯化由此获得的所需化合物(Ih)。
[0107]
本发明的化合物可以与可药用的酸或碱形成盐,比如与无机酸比如盐酸、硫酸、硝酸、磷酸、氢氟酸、氢溴酸等的盐;与有机酸比如蚁酸、乙酸、草酸、琥珀酸、马来酸、酒石酸、乳酸、柠檬酸、富马酸等的盐;与有机碱比如铵、三甲基铵、三乙基铵等的盐;与碱金属比如钠、钾等的盐;与碱土金属比如钙、镁等的盐。
[0108]
而且,本发明的化合物和其如上述的可药用的盐可以制备为其溶剂合物(优选为水合物)的形式。这类溶剂合物包括与有机溶剂和/或水的溶剂合物。可以配位任意数目的溶剂分子来形成这类溶剂合物。
[0109]
本发明的化合物(I)并不限于特定的异构体,因而本发明包括所有可能的异构体和消旋体。而且,本发明意欲包括以下所示的互变异构体。
[化学式31]
[0110]
本发明的化合物可以是具有特定立体构造的经分离的对映体或其混合物。例如,本发明的化合物可以是在所述吡咯烷二酮(pyrrolidinone)环的5位具有特定立体构造的经分离的对映体或该对映体的混合物。本领域技术人员可以使用常规方法比如重结晶、酶反应、色谱法等容易地分离这类具有特定立体构造的对映体。
[0111]
通式(I)表示的本发明的化合物对P2X3和/或P2X2/3受体具有拮抗作用,因而有用于作为与P2X3和/或P2X2/3受体相关的疾病的治疗剂。因为P2X3和/或P2X2/3受体被认为与疼痛和泌尿系统疾病相关(Nature407,26,1011-1015(2000),Nature,Vol.407,No.26,1015-1017(2000),非专利文献1,非专利文献2等),本发明的化合物有用于下列疾病的治疗、症状减轻或预防,比如:例如与类风湿性关节炎相关的疼痛、与骨关节炎相关的疼痛、头痛、偏头痛、口颌面痛、牙痛、痛风性舌痛、与颞下颌关节炎相关的疼痛、三叉神经痛、肩痛、与椎间盘突出相关的疼痛、与变形性颈椎病相关的疼痛、与脊椎管狭窄相关的疼痛、与胸部出口综合征相关的疼痛、与创伤性臂丛神经损伤综合征相关的疼痛、与肩手综合征相关的疼痛、与挥鞭性损伤相关的疼痛、胸痛、腹痛、疝痛、与胆石病相关的疼痛、与胰腺炎相关的疼痛、与尿路结石相关的疼痛、与过敏性肠综合征相关的疼痛、腰椎背痛、坐骨神经痛、与骨折相关的疼痛、与骨质疏松症相关的疼痛、关节痛、与痛风相关的疼痛、与马尾综合征相关的疼痛、与强直性脊柱炎相关的疼痛、肌肉痛、与疼痛性痉挛相关的疼痛、与肌筋膜痛综合征相关的疼痛、与纤维肌痛综合征相关的疼痛、与闭塞性动脉硬化相关的疼痛、与伯格病相关的疼痛、与雷诺氏现象相关的疼痛、与带状疱疹相关的疼痛、灼性神经痛、与压迫性神经病相关的疼痛、与腕管综合征相关的疼痛、与糖尿病相关的疼痛、与吉-巴综合征相关的疼痛、与汉森氏病相关的疼痛、与药物疗法相关的疼痛、与放射疗法相关的疼痛、与脊髓损伤相关的疼痛、与脊髓空洞症相关的疼痛、与脑卒中相关的疼痛、丘脑性疼痛、与传入神经阻滞相关的疼痛、交感神经依存性疼痛、与ABC综合征相关的疼痛、与多发性硬化相关的疼痛、与皮肤病相关的疼痛、癌症疼痛、术后疼痛、与损伤相关的疼痛、与坏疽相关的疼痛、与躯体表现性障碍相关的疼痛、与躯体症状化障碍相关的疼痛、与抑郁症相关的疼痛、与帕金森氏病相关的疼痛、膝关节疼痛、与关节炎相关的疼痛、比如月经痛、经间痛、阵痛等的神经性疼痛、炎症性疼痛、感受伤害性疼痛、心因性疼痛以及膀胱过度活动症、失禁、频尿、尿意逼迫、膀胱萎缩、前列腺肥大、前列腺炎、前列腺疼痛、逼尿肌反射亢进、排尿困难、神经性频尿、慢性前列腺炎、慢性膀胱炎等。
[0112]
本发明的化合物可以是减少了副作用(比如对运动机能的影响)的药物,因为它对ATP受体、尤其是P2X3受体具有高亲合力,并且还具有高亚型选择性,和对其它受体的高选择性。并且,本发明的化合物的优点在于其稳定性高和口服吸收率高、生物利用率良好、清除率低、半衰期长、药效持续时间延长和/或肝酶抑制作用活性低等。
[0113]
在另外的实施方案中,本发明提供下述药物组合物,其包含与可药用的载体组合的有效量的本发明的化合物。
[0114]
对本发明的化合物作为药物使用而言,可以根据常规方法使用本领域所熟知的可药用载体比如赋形剂、粘合剂、崩解剂、润滑剂、着色剂、矫味剂、表面活性剂等来制备药物组合物。
[0115]
对于欲在治疗包括人的哺乳动物中进行给药的本发明的药物组合物而言,可以根据治疗目的和给药途径来选择合适的给药单位剂型。具体地,这样的单位剂型包括口服制剂比如片剂、包衣片剂、散剂、颗粒剂、胶囊剂、液体剂、丸剂、混悬剂、乳剂等,以及肠道外制剂比如注射剂、栓剂、软膏剂、贴剂、气雾剂等。这些单位剂型可以根据本领域所熟知的方法而制剂。
[0116]
制剂中应含有的本发明化合物的量可以根据剂型、给药途径、给药方案等而改变。
[0117]
所述药物组合物的给药方法可以根据制剂的剂型、患者的年龄、性别、体重、疾病的严重程度以及其它因素等来适当选择,而给药途径可以选自各种途径比如口服、皮下、透皮、直肠、鼻腔、口腔等。
[0118]
本发明的药物组合物中所含的本发明的化合物的用量可以根据给药途径、患者的年龄、性别、体重、疾病的严重程度、待施用的本发明化合物的种类以及其它因素等来适当决定,且对于成年人口服而言,通常可为0.05-1000mg/kg/天,优选0.1-10mg/kg/天。对于肠道外给药,剂量可以根据给药途径而大为不同,但通常为0.005-100mg/kg/天,优选为0.01-1mg/kg/天。这些本发明的药物组合物可以每天给药1次或一天分为数次给药。
[0119]
本发明的化合物的优选实施方案表示为式(a)-(f):
[化学式32]
[表1]
Z1 | |
ZA | OH |
ZB | OAc |
ZC | NHOH |
[表2]
R1 | |
R1A | COOEt |
R1B | CF3 |
R1C | OCF3 |
R1D | SCF3 |
R1E | Ac |
R1F | Br |
R1G | 2-或5-噁唑基 |
R1H | 异噁唑基-3-基 |
R1I | 3-Me-异噁唑基-5-基 |
R1J | 5-Me-异噁唑基-3-基 |
R1K | 1,2,4-噁二唑-3-基 |
R1L | 1,3,4-噁二唑基-2-基 |
R1M | 5-Me-1,2,4-噁二唑-3-基 |
R1N | 3-Me-1,2,4-噁二唑-5-基 |
R1O | C(Me)=NOMe |
R1P | CH=NOMe |
R1Q | 2-噁唑啉基 |
R1R | 2-噻唑啉基 |
R1S | 1,3-二氧戊环-2-基 |
[表3]
R2 | |
R2A | iPr |
R2B | nBu |
R2C | tBu |
R2D | cBu |
R2E | cHex |
R2F | Ph |
R2G | 4-Cl或F-Ph |
R2H | 4-NO2-Ph |
R2I | 4-CF3-Ph |
R2J | 4-Me2N-Ph |
R2K | 2-或3-噻吩基 |
R2L | 3-吡啶基 |
R2M | 6-MeO-3-吡啶基 |
R2N | 2-或3-或4-MeO-Ph |
[表4]
R3 | |
R3A | iPr |
R3B | Et2CH |
R3C | Pr2CH |
R3D | nBu2CH |
R3E | Pr(Me)CH |
R3F | Ph(Me)CH |
R3G | cPent |
R3H | cHex |
R3I | Ph |
R3J | 2-Cl-Ph |
R3K | 2-或3-或4-Me-Ph |
R3L | 2-或3-或4-MeO-Ph |
R3M | 2-或3-或4-F-Ph |
R3N | 3-或4-Cl-Ph |
R3O | 2-吡啶基 |
R3P | 4-哌啶基 |
R3Q | 1-Ac-4-哌啶基 |
R3R | 四氢吡喃-4-基 |
其中
Ac为乙酰基,Me为甲基,Et为乙基,Pr为丙基,iPr为异丙基,nBu为正丁基,tBu为叔丁基,cBu为环丁基,cPent为环戊基,cHex为环己基,Ph为苯基;和
[0120]
Z1、R1、R2和R3的组合,例如(Z1,R1,R2,R3)为下述组合中的任一项:
(Z1,R1,R2,R3)= (ZA,R1A,R2A,R3A),(ZA,R1A,R2A,R3B),
(ZA,R1A,R2A,R3C),(ZA,R1A,R2A,R3D),(ZA,R1A,R2A,R3E),
(ZA,R1A,R2A,R3F),(ZA,R1A,R2A,R3G),(ZA,R1A,R2A,R3H),
(ZA,R1A,R2A,R3I),(ZA,R1A,R2A,R3J),(ZA,R1A,R2A,R3K),
(ZA,R1A,R2A,R3L),(ZA,R1A,R2A,R3M),(ZA,R1A,R2A,R3N),
(ZA,R1A,R2A,R3O),(ZA,R1A,R2A,R3P),(ZA,R1A,R2A,R3Q),
(ZA,R1A,R2A,R3R),(ZA,R1A,R2B,R3A),(ZA,R1A,R2B,R3B),
(ZA,R1A,R2B,R3C),(ZA,R1A,R2B,R3D),(ZA,R1A,R2B,R3E),
(ZA,R1A,R2B,R3F),(ZA,R1A,R2B,R3G),(ZA,R1A,R2B,R3H),
(ZA,R1A,R2B,R3I),(ZA,R1A,R2B,R3J),(ZA,R1A,R2B,R3K),
(ZA,R1A,R2B,R3L),(ZA,R1A,R2B,R3M),(ZA,R1A,R2B,R3N),
(ZA,R1A,R2B,R3O),(ZA,R1A,R2B,R3P),(ZA,R1A,R2B,R3Q),
(ZA,R1A,R2B,R3R),(ZA,R1A,R2C,R3A),(ZA,R1A,R2C,R3B),
(ZA,R1A,R2C,R3C),(ZA,R1A,R2C,R3D),(ZA,R1A,R2C,R3E),
(ZA,R1A,R2C,R3F),(ZA,R1A,R2C,R3G),(ZA,R1A,R2C,R3H),
(ZA,R1A,R2C,R3I),(ZA,R1A,R2C,R3J),(ZA,R1A,R2C,R3K),
(ZA,R1A,R2C,R3L),(ZA,R1A,R2C,R3M),(ZA,R1A,R2C,R3N),
(ZA,R1A,R2C,R3O),(ZA,R1A,R2C,R3P),(ZA,R1A,R2C,R3Q),
(ZA,R1A,R2C,R3R),(ZA,R1A,R2D,R3A),(ZA,R1A,R2D,R3B),
(ZA,R1A,R2D,R3C),(ZA,R1A,R2D,R3D),(ZA,R1A,R2D,R3E),
(ZA,R1A,R2D,R3F),(ZA,R1A,R2D,R3G),(ZA,R1A,R2D,R3H),
(ZA,R1A,R2D,R3I),(ZA,R1A,R2D,R3J),(ZA,R1A,R2D,R3K),
(ZA,R1A,R2D,R3L),(ZA,R1A,R2D,R3M),(ZA,R1A,R2D,R3N),
(ZA,R1A,R2D,R3O),(ZA,R1A,R2D,R3P),(ZA,R1A,R2D,R3Q),
(ZA,R1A,R2D,R3R),(ZA,R1A,R2E,R3A),(ZA,R1A,R2E,R3B),
(ZA,R1A,R2E,R3C),(ZA,R1A,R2E,R3D),(ZA,R1A,R2E,R3E),
(ZA,R1A,R2E,R3F),(ZA,R1A,R2E,R3G),(ZA,R1A,R2E,R3H),
(ZA,R1A,R2E,R3I),(ZA,R1A,R2E,R3J),(ZA,R1A,R2E,R3K),
(ZA,R1A,R2E,R3L),(ZA,R1A,R2E,R3M),(ZA,R1A,R2E,R3N),
(ZA,R1A,R2E,R3O),(ZA,R1A,R2E,R3P),(ZA,R1A,R2E,R3Q),
(ZA,R1A,R2E,R3R),(ZA,R1A,R2F,R3A),(ZA,R1A,R2F,R3B),
(ZA,R1A,R2F,R3C),(ZA,R1A,R2F,R3D),(ZA,R1A,R2F,R3E),
(ZA,R1A,R2F,R3F),(ZA,R1A,R2F,R3G),(ZA,R1A,R2F,R3H),
(ZA,R1A,R2F,R3I),(ZA,R1A,R2F,R3J),(ZA,R1A,R2F,R3K),
(ZA,R1A,R2F,R3L),(ZA,R1A,R2F,R3M),(ZA,R1A,R2F,R3N),
(ZA,R1A,R2F,R3O),(ZA,R1A,R2F,R3P),(ZA,R1A,R2F,R3Q),
(ZA,R1A,R2F,R3R),(ZA,R1A,R2G,R3A),(ZA,R1A,R2G,R3B),
(ZA,R1A,R2G,R3C),(ZA,R1A,R2G,R3D),(ZA,R1A,R2G,R3E),
(ZA,R1A,R2G,R3F),(ZA,R1A,R2G,R3G),(ZA,R1A,R2G,R3H),
(ZA,R1A,R2G,R3I),(ZA,R1A,R2G,R3J),(ZA,R1A,R2G,R3K),
(ZA,R1A,R2G,R3L),(ZA,R1A,R2G,R3M),(ZA,R1A,R2G,R3N),
(ZA,R1A,R2G,R3O),(ZA,R1A,R2G,R3P),(ZA,R1A,R2G,R3Q),
(ZA,R1A,R2G,R3R),(ZA,R1A,R2H,R3A),(ZA,R1A,R2H,R3B),
(ZA,R1A,R2H,R3C),(ZA,R1A,R2H,R3D),(ZA,R1A,R2H,R3E),
(ZA,R1A,R2H,R3F),(ZA,R1A,R2H,R3G),(ZA,R1A,R2H,R3H),
(ZA,R1A,R2H,R3I),(ZA,R1A,R2H,R3J),(ZA,R1A,R2H,R3K),
(ZA,R1A,R2H,R3L),(ZA,R1A,R2H,R3M),(ZA,R1A,R2H,R3N),
(ZA,R1A,R2H,R3O),(ZA,R1A,R2H,R3P),(ZA,R1A,R2H,R3Q),
(ZA,R1A,R2H,R3R),(ZA,R1A,R2I,R3A),(ZA,R1A,R2I,R3B),
(ZA,R1A,R2I,R3C),(ZA,R1A,R2I,R3D),(ZA,R1A,R2I,R3E),
(ZA,R1A,R2I,R3F),(ZA,R1A,R2I,R3G),(ZA,R1A,R2I,R3H),
(ZA,R1A,R2I,R3I),(ZA,R1A,R2I,R3J),(ZA,R1A,R2I,R3K),
(ZA,R1A,R2I,R3L),(ZA,R1A,R2I,R3M),(ZA,R1A,R2I,R3N),
(ZA,R1A,R2I,R3O),(ZA,R1A,R2I,R3P),(ZA,R1A,R2I,R3Q),
(ZA,R1A,R2I,R3R),(ZA,R1A,R2J,R3A),(ZA,R1A,R2J,R3B),
(ZA,R1A,R2J,R3C),(ZA,R1A,R2J,R3D),(ZA,R1A,R2J,R3E),
(ZA,R1A,R2J,R3F),(ZA,R1A,R2J,R3G),(ZA,R1A,R2J,R3H),
(ZA,R1A,R2J,R3I),(ZA,R1A,R2J,R3J),(ZA,R1A,R2J,R3K),
(ZA,R1A,R2J,R3L),(ZA,R1A,R2J,R3M),(ZA,R1A,R2J,R3N),
(ZA,R1A,R2J,R3O),(ZA,R1A,R2J,R3P),(ZA,R1A,R2J,R3Q),
(ZA,R1A,R2J,R3R),(ZA,R1A,R2K,R3A),(ZA,R1A,R2K,R3B),
(ZA,R1A,R2K,R3C),(ZA,R1A,R2K,R3D),(ZA,R1A,R2K,R3E),
(ZA,R1A,R2K,R3F),(ZA,R1A,R2K,R3G),(ZA,R1A,R2K,R3H),
(ZA,R1A,R2K,R3I),(ZA,R1A,R2K,R3J),(ZA,R1A,R2K,R3K),
(ZA,R1A,R2K,R3L),(ZA,R1A,R2K,R3M),(ZA,R1A,R2K,R3N),
(ZA,R1A,R2K,R3O),(ZA,R1A,R2K,R3P),(ZA,R1A,R2K,R3Q),
(ZA,R1A,R2K,R3R),(ZA,R1A,R2L,R3A),(ZA,R1A,R2L,R3B),
(ZA,R1A,R2L,R3C),(ZA,R1A,R2L,R3D),(ZA,R1A,R2L,R3E),
(ZA,R1A,R2L,R3F),(ZA,R1A,R2L,R3G),(ZA,R1A,R2L,R3H),
(ZA,R1A,R2L,R3I),(ZA,R1A,R2L,R3J),(ZA,R1A,R2L,R3K),
(ZA,R1A,R2L,R3L),(ZA,R1A,R2L,R3M),(ZA,R1A,R2L,R3N),
(ZA,R1A,R2L,R3O),(ZA,R1A,R2L,R3P),(ZA,R1A,R2L,R3Q),
(ZA,R1A,R2L,R3R),(ZA,R1A,R2M,R3A),(ZA,R1A,R2M,R3B),
(ZA,R1A,R2M,R3C),(ZA,R1A,R2M,R3D),(ZA,R1A,R2M,R3E),
(ZA,R1A,R2M,R3F),(ZA,R1A,R2M,R3G),(ZA,R1A,R2M,R3H),
(ZA,R1A,R2M,R3I),(ZA,R1A,R2M,R3J),(ZA,R1A,R2M,R3K),
(ZA,R1A,R2M,R3L),(ZA,R1A,R2M,R3M),(ZA,R1A,R2M,R3N),
(ZA,R1A,R2M,R3O),(ZA,R1A,R2M,R3P),(ZA,R1A,R2M,R3Q),
(ZA,R1A,R2M,R3R),(ZA,R1A,R2N,R3A),(ZA,R1A,R2N,R3B),
(ZA,R1A,R2N,R3C),(ZA,R1A,R2N,R3D),(ZA,R1A,R2N,R3E),
(ZA,R1A,R2N,R3F),(ZA,R1A,R2N,R3G),(ZA,R1A,R2N,R3H),
(ZA,R1A,R2N,R3I),(ZA,R1A,R2N,R3J),(ZA,R1A,R2N,R3K),
(ZA,R1A,R2N,R3L),(ZA,R1A,R2N,R3M),(ZA,R1A,R2N,R3N),
(ZA,R1A,R2N,R3O),(ZA,R1A,R2N,R3P),(ZA,R1A,R2N,R3Q),
(ZA,R1A,R2N,R3R),(ZA,R1B,R2A,R3A),(ZA,R1B,R2A,R3B),
(ZA,R1B,R2A,R3C),(ZA,R1B,R2A,R3D),(ZA,R1B,R2A,R3E),
(ZA,R1B,R2A,R3F),(ZA,R1B,R2A,R3G),(ZA,R1B,R2A,R3H),
(ZA,R1B,R2A,R3I),(ZA,R1B,R2A,R3J),(ZA,R1B,R2A,R3K),
(ZA,R1B,R2A,R3L),(ZA,R1B,R2A,R3M),(ZA,R1B,R2A,R3N),
(ZA,R1B,R2A,R3O),(ZA,R1B,R2A,R3P),(ZA,R1B,R2A,R3Q),
(ZA,R1B,R2A,R3R),(ZA,R1B,R2B,R3A),(ZA,R1B,R2B,R3B),
(ZA,R1B,R2B,R3C),(ZA,R1B,R2B,R3D),(ZA,R1B,R2B,R3E),
(ZA,R1B,R2B,R3F),(ZA,R1B,R2B,R3G),(ZA,R1B,R2B,R3H),
(ZA,R1B,R2B,R3I),(ZA,R1B,R2B,R3J),(ZA,R1B,R2B,R3K),
(ZA,R1B,R2B,R3L),(ZA,R1B,R2B,R3M),(ZA,R1B,R2B,R3N),
(ZA,R1B,R2B,R3O),(ZA,R1B,R2B,R3P),(ZA,R1B,R2B,R3Q),
(ZA,R1B,R2B,R3R),(ZA,R1B,R2C,R3A),(ZA,R1B,R2C,R3B),
(ZA,R1B,R2C,R3C),(ZA,R1B,R2C,R3D),(ZA,R1B,R2C,R3E),
(ZA,R1B,R2C,R3F),(ZA,R1B,R2C,R3G),(ZA,R1B,R2C,R3H),
(ZA,R1B,R2C,R3I),(ZA,R1B,R2C,R3J),(ZA,R1B,R2C,R3K),
(ZA,R1B,R2C,R3L),(ZA,R1B,R2C,R3M),(ZA,R1B,R2C,R3N),
(ZA,R1B,R2C,R3O),(ZA,R1B,R2C,R3P),(ZA,R1B,R2C,R3Q),
(ZA,R1B,R2C,R3R),(ZA,R1B,R2D,R3A),(ZA,R1B,R2D,R3B),
(ZA,R1B,R2D,R3C),(ZA,R1B,R2D,R3D),(ZA,R1B,R2D,R3E),
(ZA,R1B,R2D,R3F),(ZA,R1B,R2D,R3G),(ZA,R1B,R2D,R3H),
(ZA,R1B,R2D,R3I),(ZA,R1B,R2D,R3J),(ZA,R1B,R2D,R3K),
(ZA,R1B,R2D,R3L),(ZA,R1B,R2D,R3M),(ZA,R1B,R2D,R3N),
(ZA,R1B,R2D,R3O),(ZA,R1B,R2D,R3P),(ZA,R1B,R2D,R3Q),
(ZA,R1B,R2D,R3R),(ZA,R1B,R2E,R3A),(ZA,R1B,R2E,R3B),
(ZA,R1B,R2E,R3C),(ZA,R1B,R2E,R3D),(ZA,R1B,R2E,R3E),
(ZA,R1B,R2E,R3F),(ZA,R1B,R2E,R3G),(ZA,R1B,R2E,R3H),
(ZA,R1B,R2E,R3I),(ZA,R1B,R2E,R3J),(ZA,R1B,R2E,R3K),
(ZA,R1B,R2E,R3L),(ZA,R1B,R2E,R3M),(ZA,R1B,R2E,R3N),
(ZA,R1B,R2E,R3O),(ZA,R1B,R2E,R3P),(ZA,R1B,R2E,R3Q),
(ZA,R1B,R2E,R3R),(ZA,R1B,R2F,R3A),(ZA,R1B,R2F,R3B),
(ZA,R1B,R2F,R3C),(ZA,R1B,R2F,R3D),(ZA,R1B,R2F,R3E),
(ZA,R1B,R2F,R3F),(ZA,R1B,R2F,R3G),(ZA,R1B,R2F,R3H),
(ZA,R1B,R2F,R3I),(ZA,R1B,R2F,R3J),(ZA,R1B,R2F,R3K),
(ZA,R1B,R2F,R3L),(ZA,R1B,R2F,R3M),(ZA,R1B,R2F,R3N),
(ZA,R1B,R2F,R3O),(ZA,R1B,R2F,R3P),(ZA,R1B,R2F,R3Q),
(ZA,R1B,R2F,R3R),(ZA,R1B,R2G,R3A),(ZA,R1B,R2G,R3B),
(ZA,R1B,R2G,R3C),(ZA,R1B,R2G,R3D),(ZA,R1B,R2G,R3E),
(ZA,R1B,R2G,R3F),(ZA,R1B,R2G,R3G),(ZA,R1B,R2G,R3H),
(ZA,R1B,R2G,R3I),(ZA,R1B,R2G,R3J),(ZA,R1B,R2G,R3K),
(ZA,R1B,R2G,R3L),(ZA,R1B,R2G,R3M),(ZA,R1B,R2G,R3N),
(ZA,R1B,R2G,R3O),(ZA,R1B,R2G,R3P),(ZA,R1B,R2G,R3Q),
(ZA,R1B,R2G,R3R),(ZA,R1B,R2H,R3A),(ZA,R1B,R2H,R3B),
(ZA,R1B,R2H,R3C),(ZA,R1B,R2H,R3D),(ZA,R1B,R2H,R3E),
(ZA,R1B,R2H,R3F),(ZA,R1B,R2H,R3G),(ZA,R1B,R2H,R3H),
(ZA,R1B,R2H,R3I),(ZA,R1B,R2H,R3J),(ZA,R1B,R2H,R3K),
(ZA,R1B,R2H,R3L),(ZA,R1B,R2H,R3M),(ZA,R1B,R2H,R3N),
(ZA,R1B,R2H,R3O),(ZA,R1B,R2H,R3P),(ZA,R1B,R2H,R3Q),
(ZA,R1B,R2H,R3R),(ZA,R1B,R2I,R3A),(ZA,R1B,R2I,R3B),
(ZA,R1B,R2I,R3C),(ZA,R1B,R2I,R3D),(ZA,R1B,R2I,R3E),
(ZA,R1B,R2I,R3F),(ZA,R1B,R2I,R3G),(ZA,R1B,R2I,R3H),
(ZA,R1B,R2I,R3I),(ZA,R1B,R2I,R3J),(ZA,R1B,R2I,R3K),
(ZA,R1B,R2I,R3L),(ZA,R1B,R2I,R3M),(ZA,R1B,R2I,R3N),
(ZA,R1B,R2I,R3O),(ZA,R1B,R2I,R3P),(ZA,R1B,R2I,R3Q),
(ZA,R1B,R2I,R3R),(ZA,R1B,R2J,R3A),(ZA,R1B,R2J,R3B),
(ZA,R1B,R2J,R3C),(ZA,R1B,R2J,R3D),(ZA,R1B,R2J,R3E),
(ZA,R1B,R2J,R3F),(ZA,R1B,R2J,R3G),(ZA,R1B,R2J,R3H),
(ZA,R1B,R2J,R3I),(ZA,R1B,R2J,R3J),(ZA,R1B,R2J,R3K),
(ZA,R1B,R2J,R3L),(ZA,R1B,R2J,R3M),(ZA,R1B,R2J,R3N),
(ZA,R1B,R2J,R3O),(ZA,R1B,R2J,R3P),(ZA,R1B,R2J,R3Q),
(ZA,R1B,R2J,R3R),(ZA,R1B,R2K,R3A),(ZA,R1B,R2K,R3B),
(ZA,R1B,R2K,R3C),(ZA,R1B,R2K,R3D),(ZA,R1B,R2K,R3E),
(ZA,R1B,R2K,R3F),(ZA,R1B,R2K,R3G),(ZA,R1B,R2K,R3H),
(ZA,R1B,R2K,R3I),(ZA,R1B,R2K,R3J),(ZA,R1B,R2K,R3K),
(ZA,R1B,R2K,R3L),(ZA,R1B,R2K,R3M),(ZA,R1B,R2K,R3N),
(ZA,R1B,R2K,R3O),(ZA,R1B,R2K,R3P),(ZA,R1B,R2K,R3Q),
(ZA,R1B,R2K,R3R),(ZA,R1B,R2L,R3A),(ZA,R1B,R2L,R3B),
(ZA,R1B,R2L,R3C),(ZA,R1B,R2L,R3D),(ZA,R1B,R2L,R3E),
(ZA,R1B,R2L,R3F),(ZA,R1B,R2L,R3G),(ZA,R1B,R2L,R3H),
(ZA,R1B,R2L,R3I),(ZA,R1B,R2L,R3J),(ZA,R1B,R2L,R3K),
(ZA,R1B,R2L,R3L),(ZA,R1B,R2L,R3M),(ZA,R1B,R2L,R3N),
(ZA,R1B,R2L,R3O),(ZA,R1B,R2L,R3P),(ZA,R1B,R2L,R3Q),
(ZA,R1B,R2L,R3R),(ZA,R1B,R2M,R3A),(ZA,R1B,R2M,R3B),
(ZA,R1B,R2M,R3C),(ZA,R1B,R2M,R3D),(ZA,R1B,R2M,R3E),
(ZA,R1B,R2M,R3F),(ZA,R1B,R2M,R3G),(ZA,R1B,R2M,R3H),
(ZA,R1B,R2M,R3I),(ZA,R1B,R2M,R3J),(ZA,R1B,R2M,R3K),
(ZA,R1B,R2M,R3L),(ZA,R1B,R2M,R3M),(ZA,R1B,R2M,R3N),
(ZA,R1B,R2M,R3O),(ZA,R1B,R2M,R3P),(ZA,R1B,R2M,R3Q),
(ZA,R1B,R2M,R3R),(ZA,R1B,R2N,R3A),(ZA,R1B,R2N,R3B),
(ZA,R1B,R2N,R3C),(ZA,R1B,R2N,R3D),(ZA,R1B,R2N,R3E),
(ZA,R1B,R2N,R3F),(ZA,R1B,R2N,R3G),(ZA,R1B,R2N,R3H),
(ZA,R1B,R2N,R3I),(ZA,R1B,R2N,R3J),(ZA,R1B,R2N,R3K),
(ZA,R1B,R2N,R3L),(ZA,R1B,R2N,R3M),(ZA,R1B,R2N,R3N),
(ZA,R1B,R2N,R3O),(ZA,R1B,R2N,R3P),(ZA,R1B,R2N,R3Q),
(ZA,R1B,R2N,R3R),(ZA,R1C,R2A,R3A),(ZA,R1C,R2A,R3B),
(ZA,R1C,R2A,R3C),(ZA,R1C,R2A,R3D),(ZA,R1C,R2A,R3E),
(ZA,R1C,R2A,R3F),(ZA,R1C,R2A,R3G),(ZA,R1C,R2A,R3H),
(ZA,R1C,R2A,R3I),(ZA,R1C,R2A,R3J),(ZA,R1C,R2A,R3K),
(ZA,R1C,R2A,R3L),(ZA,R1C,R2A,R3M),(ZA,R1C,R2A,R3N),
(ZA,R1C,R2A,R3O),(ZA,R1C,R2A,R3P),(ZA,R1C,R2A,R3Q),
(ZA,R1C,R2A,R3R),(ZA,R1C,R2B,R3A),(ZA,R1C,R2B,R3B),
(ZA,R1C,R2B,R3C),(ZA,R1C,R2B,R3D),(ZA,R1C,R2B,R3E),
(ZA,R1C,R2B,R3F),(ZA,R1C,R2B,R3G),(ZA,R1C,R2B,R3H),
(ZA,R1C,R2B,R3I),(ZA,R1C,R2B,R3J),(ZA,R1C,R2B,R3K),
(ZA,R1C,R2B,R3L),(ZA,R1C,R2B,R3M),(ZA,R1C,R2B,R3N),
(ZA,R1C,R2B,R3O),(ZA,R1C,R2B,R3P),(ZA,R1C,R2B,R3Q),
(ZA,R1C,R2B,R3R),(ZA,R1C,R2C,R3A),(ZA,R1C,R2C,R3B),
(ZA,R1C,R2C,R3C),(ZA,R1C,R2C,R3D),(ZA,R1C,R2C,R3E),
(ZA,R1C,R2C,R3F),(ZA,R1C,R2C,R3G),(ZA,R1C,R2C,R3H),
(ZA,R1C,R2C,R3I),(ZA,R1C,R2C,R3J),(ZA,R1C,R2C,R3K),
(ZA,R1C,R2C,R3L),(ZA,R1C,R2C,R3M),(ZA,R1C,R2C,R3N),
(ZA,R1C,R2C,R3O),(ZA,R1C,R2C,R3P),(ZA,R1C,R2C,R3Q),
(ZA,R1C,R2C,R3R),(ZA,R1C,R2D,R3A),(ZA,R1C,R2D,R3B),
(ZA,R1C,R2D,R3C),(ZA,R1C,R2D,R3D),(ZA,R1C,R2D,R3E),
(ZA,R1C,R2D,R3F),(ZA,R1C,R2D,R3G),(ZA,R1C,R2D,R3H),
(ZA,R1C,R2D,R3I),(ZA,R1C,R2D,R3J),(ZA,R1C,R2D,R3K),
(ZA,R1C,R2D,R3L),(ZA,R1C,R2D,R3M),(ZA,R1C,R2D,R3N),
(ZA,R1C,R2D,R3O),(ZA,R1C,R2D,R3P),(ZA,R1C,R2D,R3Q),
(ZA,R1C,R2D,R3R),(ZA,R1C,R2E,R3A),(ZA,R1C,R2E,R3B),
(ZA,R1C,R2E,R3C),(ZA,R1C,R2E,R3D),(ZA,R1C,R2E,R3E),
(ZA,R1C,R2E,R3F),(ZA,R1C,R2E,R3G),(ZA,R1C,R2E,R3H),
(ZA,R1C,R2E,R3I),(ZA,R1C,R2E,R3J),(ZA,R1C,R2E,R3K),
(ZA,R1C,R2E,R3L),(ZA,R1C,R2E,R3M),(ZA,R1C,R2E,R3N),
(ZA,R1C,R2E,R3O),(ZA,R1C,R2E,R3P),(ZA,R1C,R2E,R3Q),
(ZA,R1C,R2E,R3R),(ZA,R1C,R2F,R3A),(ZA,R1C,R2F,R3B),
(ZA,R1C,R2F,R3C),(ZA,R1C,R2F,R3D),(ZA,R1C,R2F,R3E),
(ZA,R1C,R2F,R3F),(ZA,R1C,R2F,R3G),(ZA,R1C,R2F,R3H),
(ZA,R1C,R2F,R3I),(ZA,R1C,R2F,R3J),(ZA,R1C,R2F,R3K),
(ZA,R1C,R2F,R3L),(ZA,R1C,R2F,R3M),(ZA,R1C,R2F,R3N),
(ZA,R1C,R2F,R3O),(ZA,R1C,R2F,R3P),(ZA,R1C,R2F,R3Q),
(ZA,R1C,R2F,R3R),(ZA,R1C,R2G,R3A),(ZA,R1C,R2G,R3B),
(ZA,R1C,R2G,R3C),(ZA,R1C,R2G,R3D),(ZA,R1C,R2G,R3E),
(ZA,R1C,R2G,R3F),(ZA,R1C,R2G,R3G),(ZA,R1C,R2G,R3H),
(ZA,R1C,R2G,R3I),(ZA,R1C,R2G,R3J),(ZA,R1C,R2G,R3K),
(ZA,R1C,R2G,R3L),(ZA,R1C,R2G,R3M),(ZA,R1C,R2G,R3N),
(ZA,R1C,R2G,R3O),(ZA,R1C,R2G,R3P),(ZA,R1C,R2G,R3Q),
(ZA,R1C,R2G,R3R),(ZA,R1C,R2H,R3A),(ZA,R1C,R2H,R3B),
(ZA,R1C,R2H,R3C),(ZA,R1C,R2H,R3D),(ZA,R1C,R2H,R3E),
(ZA,R1C,R2H,R3F),(ZA,R1C,R2H,R3G),(ZA,R1C,R2H,R3H),
(ZA,R1C,R2H,R3I),(ZA,R1C,R2H,R3J),(ZA,R1C,R2H,R3K),
(ZA,R1C,R2H,R3L),(ZA,R1C,R2H,R3M),(ZA,R1C,R2H,R3N),
(ZA,R1C,R2H,R3O),(ZA,R1C,R2H,R3P),(ZA,R1C,R2H,R3Q),
(ZA,R1C,R2H,R3R),(ZA,R1C,R2I,R3A),(ZA,R1C,R2I,R3B),
(ZA,R1C,R2I,R3C),(ZA,R1C,R2I,R3D),(ZA,R1C,R2I,R3E),
(ZA,R1C,R2I,R3F),(ZA,R1C,R2I,R3G),(ZA,R1C,R2I,R3H),
(ZA,R1C,R2I,R3I),(ZA,R1C,R2I,R3J),(ZA,R1C,R2I,R3K),
(ZA,R1C,R2I,R3L),(ZA,R1C,R2I,R3M),(ZA,R1C,R2I,R3N),
(ZA,R1C,R2I,R3O),(ZA,R1C,R2I,R3P),(ZA,R1C,R2I,R3Q),
(ZA,R1C,R2I,R3R),(ZA,R1C,R2J,R3A),(ZA,R1C,R2J,R3B),
(ZA,R1C,R2J,R3C),(ZA,R1C,R2J,R3D),(ZA,R1C,R2J,R3E),
(ZA,R1C,R2J,R3F),(ZA,R1C,R2J,R3G),(ZA,R1C,R2J,R3H),
(ZA,R1C,R2J,R3I),(ZA,R1C,R2J,R3J),(ZA,R1C,R2J,R3K),
(ZA,R1C,R2J,R3L),(ZA,R1C,R2J,R3M),(ZA,R1C,R2J,R3N),
(ZA,R1C,R2J,R3O),(ZA,R1C,R2J,R3P),(ZA,R1C,R2J,R3Q),
(ZA,R1C,R2J,R3R),(ZA,R1C,R2K,R3A),(ZA,R1C,R2K,R3B),
(ZA,R1C,R2K,R3C),(ZA,R1C,R2K,R3D),(ZA,R1C,R2K,R3E),
(ZA,R1C,R2K,R3F),(ZA,R1C,R2K,R3G),(ZA,R1C,R2K,R3H),
(ZA,R1C,R2K,R3I),(ZA,R1C,R2K,R3J),(ZA,R1C,R2K,R3K),
(ZA,R1C,R2K,R3L),(ZA,R1C,R2K,R3M),(ZA,R1C,R2K,R3N),
(ZA,R1C,R2K,R3O),(ZA,R1C,R2K,R3P),(ZA,R1C,R2K,R3Q),
(ZA,R1C,R2K,R3R),(ZA,R1C,R2L,R3A),(ZA,R1C,R2L,R3B),
(ZA,R1C,R2L,R3C),(ZA,R1C,R2L,R3D),(ZA,R1C,R2L,R3E),
(ZA,R1C,R2L,R3F),(ZA,R1C,R2L,R3G),(ZA,R1C,R2L,R3H),
(ZA,R1C,R2L,R3I),(ZA,R1C,R2L,R3J),(ZA,R1C,R2L,R3K),
(ZA,R1C,R2L,R3L),(ZA,R1C,R2L,R3M),(ZA,R1C,R2L,R3N),
(ZA,R1C,R2L,R3O),(ZA,R1C,R2L,R3P),(ZA,R1C,R2L,R3Q),
(ZA,R1C,R2L,R3R),(ZA,R1C,R2M,R3A),(ZA,R1C,R2M,R3B),
(ZA,R1C,R2M,R3C),(ZA,R1C,R2M,R3D),(ZA,R1C,R2M,R3E),
(ZA,R1C,R2M,R3F),(ZA,R1C,R2M,R3G),(ZA,R1C,R2M,R3H),
(ZA,R1C,R2M,R3I),(ZA,R1C,R2M,R3J),(ZA,R1C,R2M,R3K),
(ZA,R1C,R2M,R3L),(ZA,R1C,R2M,R3M),(ZA,R1C,R2M,R3N),
(ZA,R1C,R2M,R3O),(ZA,R1C,R2M,R3P),(ZA,R1C,R2M,R3Q),
(ZA,R1C,R2M,R3R),(ZA,R1C,R2N,R3A),(ZA,R1C,R2N,R3B),
(ZA,R1C,R2N,R3C),(ZA,R1C,R2N,R3D),(ZA,R1C,R2N,R3E),
(ZA,R1C,R2N,R3F),(ZA,R1C,R2N,R3G),(ZA,R1C,R2N,R3H),
(ZA,R1C,R2N,R3I),(ZA,R1C,R2N,R3J),(ZA,R1C,R2N,R3K),
(ZA,R1C,R2N,R3L),(ZA,R1C,R2N,R3M),(ZA,R1C,R2N,R3N),
(ZA,R1C,R2N,R3O),(ZA,R1C,R2N,R3P),(ZA,R1C,R2N,R3Q),
(ZA,R1C,R2N,R3R),(ZA,R1D,R2A,R3A),(ZA,R1D,R2A,R3B),
(ZA,R1D,R2A,R3C),(ZA,R1D,R2A,R3D),(ZA,R1D,R2A,R3E),
(ZA,R1D,R2A,R3F),(ZA,R1D,R2A,R3G),(ZA,R1D,R2A,R3H),
(ZA,R1D,R2A,R3I),(ZA,R1D,R2A,R3J),(ZA,R1D,R2A,R3K),
(ZA,R1D,R2A,R3L),(ZA,R1D,R2A,R3M),(ZA,R1D,R2A,R3N),
(ZA,R1D,R2A,R3O),(ZA,R1D,R2A,R3P),(ZA,R1D,R2A,R3Q),
(ZA,R1D,R2A,R3R),(ZA,R1D,R2B,R3A),(ZA,R1D,R2B,R3B),
(ZA,R1D,R2B,R3C),(ZA,R1D,R2B,R3D),(ZA,R1D,R2B,R3E),
(ZA,R1D,R2B,R3F),(ZA,R1D,R2B,R3G),(ZA,R1D,R2B,R3H),
(ZA,R1D,R2B,R3I),(ZA,R1D,R2B,R3J),(ZA,R1D,R2B,R3K),
(ZA,R1D,R2B,R3L),(ZA,R1D,R2B,R3M),(ZA,R1D,R2B,R3N),
(ZA,R1D,R2B,R3O),(ZA,R1D,R2B,R3P),(ZA,R1D,R2B,R3Q),
(ZA,R1D,R2B,R3R),(ZA,R1D,R2C,R3A),(ZA,R1D,R2C,R3B),
(ZA,R1D,R2C,R3C),(ZA,R1D,R2C,R3D),(ZA,R1D,R2C,R3E),
(ZA,R1D,R2C,R3F),(ZA,R1D,R2C,R3G),(ZA,R1D,R2C,R3H),
(ZA,R1D,R2C,R3I),(ZA,R1D,R2C,R3J),(ZA,R1D,R2C,R3K),
(ZA,R1D,R2C,R3L),(ZA,R1D,R2C,R3M),(ZA,R1D,R2C,R3N),
(ZA,R1D,R2C,R3O),(ZA,R1D,R2C,R3P),(ZA,R1D,R2C,R3Q),
(ZA,R1D,R2C,R3R),(ZA,R1D,R2D,R3A),(ZA,R1D,R2D,R3B),
(ZA,R1D,R2D,R3C),(ZA,R1D,R2D,R3D),(ZA,R1D,R2D,R3E),
(ZA,R1D,R2D,R3F),(ZA,R1D,R2D,R3G),(ZA,R1D,R2D,R3H),
(ZA,R1D,R2D,R3I),(ZA,R1D,R2D,R3J),(ZA,R1D,R2D,R3K),
(ZA,R1D,R2D,R3L),(ZA,R1D,R2D,R3M),(ZA,R1D,R2D,R3N),
(ZA,R1D,R2D,R3O),(ZA,R1D,R2D,R3P),(ZA,R1D,R2D,R3Q),
(ZA,R1D,R2D,R3R),(ZA,R1D,R2E,R3A),(ZA,R1D,R2E,R3B),
(ZA,R1D,R2E,R3C),(ZA,R1D,R2E,R3D),(ZA,R1D,R2E,R3E),
(ZA,R1D,R2E,R3F),(ZA,R1D,R2E,R3G),(ZA,R1D,R2E,R3H),
(ZA,R1D,R2E,R3I),(ZA,R1D,R2E,R3J),(ZA,R1D,R2E,R3K),
(ZA,R1D,R2E,R3L),(ZA,R1D,R2E,R3M),(ZA,R1D,R2E,R3N),
(ZA,R1D,R2E,R3O),(ZA,R1D,R2E,R3P),(ZA,R1D,R2E,R3Q),
(ZA,R1D,R2E,R3R),(ZA,R1D,R2F,R3A),(ZA,R1D,R2F,R3B),
(ZA,R1D,R2F,R3C),(ZA,R1D,R2F,R3D),(ZA,R1D,R2F,R3E),
(ZA,R1D,R2F,R3F),(ZA,R1D,R2F,R3G),(ZA,R1D,R2F,R3H),
(ZA,R1D,R2F,R3I),(ZA,R1D,R2F,R3J),(ZA,R1D,R2F,R3K),
(ZA,R1D,R2F,R3L),(ZA,R1D,R2F,R3M),(ZA,R1D,R2F,R3N),
(ZA,R1D,R2F,R3O),(ZA,R1D,R2F,R3P),(ZA,R1D,R2F,R3Q),
(ZA,R1D,R2F,R3R),(ZA,R1D,R2G,R3A),(ZA,R1D,R2G,R3B),
(ZA,R1D,R2G,R3C),(ZA,R1D,R2G,R3D),(ZA,R1D,R2G,R3E),
(ZA,R1D,R2G,R3F),(ZA,R1D,R2G,R3G),(ZA,R1D,R2G,R3H),
(ZA,R1D,R2G,R3I),(ZA,R1D,R2G,R3J),(ZA,R1D,R2G,R3K),
(ZA,R1D,R2G,R3L),(ZA,R1D,R2G,R3M),(ZA,R1D,R2G,R3N),
(ZA,R1D,R2G,R3O),(ZA,R1D,R2G,R3P),(ZA,R1D,R2G,R3Q),
(ZA,R1D,R2G,R3R),(ZA,R1D,R2H,R3A),(ZA,R1D,R2H,R3B),
(ZA,R1D,R2H,R3C),(ZA,R1D,R2H,R3D),(ZA,R1D,R2H,R3E),
(ZA,R1D,R2H,R3F),(ZA,R1D,R2H,R3G),(ZA,R1D,R2H,R3H),
(ZA,R1D,R2H,R3I),(ZA,R1D,R2H,R3J),(ZA,R1D,R2H,R3K),
(ZA,R1D,R2H,R3L),(ZA,R1D,R2H,R3M),(ZA,R1D,R2H,R3N),
(ZA,R1D,R2H,R3O),(ZA,R1D,R2H,R3P),(ZA,R1D,R2H,R3Q),
(ZA,R1D,R2H,R3R),(ZA,R1D,R2I,R3A),(ZA,R1D,R2I,R3B),
(ZA,R1D,R2I,R3C),(ZA,R1D,R2I,R3D),(ZA,R1D,R2I,R3E),
(ZA,R1D,R2I,R3F),(ZA,R1D,R2I,R3G),(ZA,R1D,R2I,R3H),
(ZA,R1D,R2I,R3I),(ZA,R1D,R2I,R3J),(ZA,R1D,R2I,R3K),
(ZA,R1D,R2I,R3L),(ZA,R1D,R2I,R3M),(ZA,R1D,R2I,R3N),
(ZA,R1D,R2I,R3O),(ZA,R1D,R2I,R3P),(ZA,R1D,R2I,R3Q),
(ZA,R1D,R2I,R3R),(ZA,R1D,R2J,R3A),(ZA,R1D,R2J,R3B),
(ZA,R1D,R2J,R3C),(ZA,R1D,R2J,R3D),(ZA,R1D,R2J,R3E),
(ZA,R1D,R2J,R3F),(ZA,R1D,R2J,R3G),(ZA,R1D,R2J,R3H),
(ZA,R1D,R2J,R3I),(ZA,R1D,R2J,R3J),(ZA,R1D,R2J,R3K),
(ZA,R1D,R2J,R3L),(ZA,R1D,R2J,R3M),(ZA,R1D,R2J,R3N),
(ZA,R1D,R2J,R3O),(ZA,R1D,R2J,R3P),(ZA,R1D,R2J,R3Q),
(ZA,R1D,R2J,R3R),(ZA,R1D,R2K,R3A),(ZA,R1D,R2K,R3B),
(ZA,R1D,R2K,R3C),(ZA,R1D,R2K,R3D),(ZA,R1D,R2K,R3E),
(ZA,R1D,R2K,R3F),(ZA,R1D,R2K,R3G),(ZA,R1D,R2K,R3H),
(ZA,R1D,R2K,R3I),(ZA,R1D,R2K,R3J),(ZA,R1D,R2K,R3K),
(ZA,R1D,R2K,R3L),(ZA,R1D,R2K,R3M),(ZA,R1D,R2K,R3N),
(ZA,R1D,R2K,R3O),(ZA,R1D,R2K,R3P),(ZA,R1D,R2K,R3Q),
(ZA,R1D,R2K,R3R),(ZA,R1D,R2L,R3A),(ZA,R1D,R2L,R3B),
(ZA,R1D,R2L,R3C),(ZA,R1D,R2L,R3D),(ZA,R1D,R2L,R3E),
(ZA,R1D,R2L,R3F),(ZA,R1D,R2L,R3G),(ZA,R1D,R2L,R3H),
(ZA,R1D,R2L,R3I),(ZA,R1D,R2L,R3J),(ZA,R1D,R2L,R3K),
(ZA,R1D,R2L,R3L),(ZA,R1D,R2L,R3M),(ZA,R1D,R2L,R3N),
(ZA,R1D,R2L,R3O),(ZA,R1D,R2L,R3P),(ZA,R1D,R2L,R3Q),
(ZA,R1D,R2L,R3R),(ZA,R1D,R2M,R3A),(ZA,R1D,R2M,R3B),
(ZA,R1D,R2M,R3C),(ZA,R1D,R2M,R3D),(ZA,R1D,R2M,R3E),
(ZA,R1D,R2M,R3F),(ZA,R1D,R2M,R3G),(ZA,R1D,R2M,R3H),
(ZA,R1D,R2M,R3I),(ZA,R1D,R2M,R3J),(ZA,R1D,R2M,R3K),
(ZA,R1D,R2M,R3L),(ZA,R1D,R2M,R3M),(ZA,R1D,R2M,R3N),
(ZA,R1D,R2M,R3O),(ZA,R1D,R2M,R3P),(ZA,R1D,R2M,R3Q),
(ZA,R1D,R2M,R3R),(ZA,R1D,R2N,R3A),(ZA,R1D,R2N,R3B),
(ZA,R1D,R2N,R3C),(ZA,R1D,R2N,R3D),(ZA,R1D,R2N,R3E),
(ZA,R1D,R2N,R3F),(ZA,R1D,R2N,R3G),(ZA,R1D,R2N,R3H),
(ZA,R1D,R2N,R3I),(ZA,R1D,R2N,R3J),(ZA,R1D,R2N,R3K),
(ZA,R1D,R2N,R3L),(ZA,R1D,R2N,R3M),(ZA,R1D,R2N,R3N),
(ZA,R1D,R2N,R3O),(ZA,R1D,R2N,R3P),(ZA,R1D,R2N,R3Q),
(ZA,R1D,R2N,R3R),(ZA,R1E,R2A,R3A),(ZA,R1E,R2A,R3B),
(ZA,R1E,R2A,R3C),(ZA,R1E,R2A,R3D),(ZA,R1E,R2A,R3E),
(ZA,R1E,R2A,R3F),(ZA,R1E,R2A,R3G),(ZA,R1E,R2A,R3H),
(ZA,R1E,R2A,R3I),(ZA,R1E,R2A,R3J),(ZA,R1E,R2A,R3K),
(ZA,R1E,R2A,R3L),(ZA,R1E,R2A,R3M),(ZA,R1E,R2A,R3N),
(ZA,R1E,R2A,R3O),(ZA,R1E,R2A,R3P),(ZA,R1E,R2A,R3Q),
(ZA,R1E,R2A,R3R),(ZA,R1E,R2B,R3A),(ZA,R1E,R2B,R3B),
(ZA,R1E,R2B,R3C),(ZA,R1E,R2B,R3D),(ZA,R1E,R2B,R3E),
(ZA,R1E,R2B,R3F),(ZA,R1E,R2B,R3G),(ZA,R1E,R2B,R3H),
(ZA,R1E,R2B,R3I),(ZA,R1E,R2B,R3J),(ZA,R1E,R2B,R3K),
(ZA,R1E,R2B,R3L),(ZA,R1E,R2B,R3M),(ZA,R1E,R2B,R3N),
(ZA,R1E,R2B,R3O),(ZA,R1E,R2B,R3P),(ZA,R1E,R2B,R3Q),
(ZA,R1E,R2B,R3R),(ZA,R1E,R2C,R3A),(ZA,R1E,R2C,R3B),
(ZA,R1E,R2C,R3C),(ZA,R1E,R2C,R3D),(ZA,R1E,R2C,R3E),
(ZA,R1E,R2C,R3F),(ZA,R1E,R2C,R3G),(ZA,R1E,R2C,R3H),
(ZA,R1E,R2C,R3I),(ZA,R1E,R2C,R3J),(ZA,R1E,R2C,R3K),
(ZA,R1E,R2C,R3L),(ZA,R1E,R2C,R3M),(ZA,R1E,R2C,R3N),
(ZA,R1E,R2C,R3O),(ZA,R1E,R2C,R3P),(ZA,R1E,R2C,R3Q),
(ZA,R1E,R2C,R3R),(ZA,R1E,R2D,R3A),(ZA,R1E,R2D,R3B),
(ZA,R1E,R2D,R3C),(ZA,R1E,R2D,R3D),(ZA,R1E,R2D,R3E),
(ZA,R1E,R2D,R3F),(ZA,R1E,R2D,R3G),(ZA,R1E,R2D,R3H),
(ZA,R1E,R2D,R3I),(ZA,R1E,R2D,R3J),(ZA,R1E,R2D,R3K),
(ZA,R1E,R2D,R3L),(ZA,R1E,R2D,R3M),(ZA,R1E,R2D,R3N),
(ZA,R1E,R2D,R3O),(ZA,R1E,R2D,R3P),(ZA,R1E,R2D,R3Q),
(ZA,R1E,R2D,R3R),(ZA,R1E,R2E,R3A),(ZA,R1E,R2E,R3B),
(ZA,R1E,R2E,R3C),(ZA,R1E,R2E,R3D),(ZA,R1E,R2E,R3E),
(ZA,R1E,R2E,R3F),(ZA,R1E,R2E,R3G),(ZA,R1E,R2E,R3H),
(ZA,R1E,R2E,R3I),(ZA,R1E,R2E,R3J),(ZA,R1E,R2E,R3K),
(ZA,R1E,R2E,R3L),(ZA,R1E,R2E,R3M),(ZA,R1E,R2E,R3N),
(ZA,R1E,R2E,R3O),(ZA,R1E,R2E,R3P),(ZA,R1E,R2E,R3Q),
(ZA,R1E,R2E,R3R),(ZA,R1E,R2F,R3A),(ZA,R1E,R2F,R3B),
(ZA,R1E,R2F,R3C),(ZA,R1E,R2F,R3D),(ZA,R1E,R2F,R3E),
(ZA,R1E,R2F,R3F),(ZA,R1E,R2F,R3G),(ZA,R1E,R2F,R3H),
(ZA,R1E,R2F,R3I),(ZA,R1E,R2F,R3J),(ZA,R1E,R2F,R3K),
(ZA,R1E,R2F,R3L),(ZA,R1E,R2F,R3M),(ZA,R1E,R2F,R3N),
(ZA,R1E,R2F,R3O),(ZA,R1E,R2F,R3P),(ZA,R1E,R2F,R3Q),
(ZA,R1E,R2F,R3R),(ZA,R1E,R2G,R3A),(ZA,R1E,R2G,R3B),
(ZA,R1E,R2G,R3C),(ZA,R1E,R2G,R3D),(ZA,R1E,R2G,R3E),
(ZA,R1E,R2G,R3F),(ZA,R1E,R2G,R3G),(ZA,R1E,R2G,R3H),
(ZA,R1E,R2G,R3I),(ZA,R1E,R2G,R3J),(ZA,R1E,R2G,R3K),
(ZA,R1E,R2G,R3L),(ZA,R1E,R2G,R3M),(ZA,R1E,R2G,R3N),
(ZA,R1E,R2G,R3O),(ZA,R1E,R2G,R3P),(ZA,R1E,R2G,R3Q),
(ZA,R1E,R2G,R3R),(ZA,R1E,R2H,R3A),(ZA,R1E,R2H,R3B),
(ZA,R1E,R2H,R3C),(ZA,R1E,R2H,R3D),(ZA,R1E,R2H,R3E),
(ZA,R1E,R2H,R3F),(ZA,R1E,R2H,R3G),(ZA,R1E,R2H,R3H),
(ZA,R1E,R2H,R3I),(ZA,R1E,R2H,R3J),(ZA,R1E,R2H,R3K),
(ZA,R1E,R2H,R3L),(ZA,R1E,R2H,R3M),(ZA,R1E,R2H,R3N),
(ZA,R1E,R2H,R3O),(ZA,R1E,R2H,R3P),(ZA,R1E,R2H,R3Q),
(ZA,R1E,R2H,R3R),(ZA,R1E,R2I,R3A),(ZA,R1E,R2I,R3B),
(ZA,R1E,R2I,R3C),(ZA,R1E,R2I,R3D),(ZA,R1E,R2I,R3E),
(ZA,R1E,R2I,R3F),(ZA,R1E,R2I,R3G),(ZA,R1E,R2I,R3H),
(ZA,R1E,R2I,R3I),(ZA,R1E,R2I,R3J),(ZA,R1E,R2I,R3K),
(ZA,R1E,R2I,R3L),(ZA,R1E,R2I,R3M),(ZA,R1E,R2I,R3N),
(ZA,R1E,R2I,R3O),(ZA,R1E,R2I,R3P),(ZA,R1E,R2I,R3Q),
(ZA,R1E,R2I,R3R),(ZA,R1E,R2J,R3A),(ZA,R1E,R2J,R3B),
(ZA,R1E,R2J,R3C),(ZA,R1E,R2J,R3D),(ZA,R1E,R2J,R3E),
(ZA,R1E,R2J,R3F),(ZA,R1E,R2J,R3G),(ZA,R1E,R2J,R3H),
(ZA,R1E,R2J,R3I),(ZA,R1E,R2J,R3J),(ZA,R1E,R2J,R3K),
(ZA,R1E,R2J,R3L),(ZA,R1E,R2J,R3M),(ZA,R1E,R2J,R3N),
(ZA,R1E,R2J,R3O),(ZA,R1E,R2J,R3P),(ZA,R1E,R2J,R3Q),
(ZA,R1E,R2J,R3R),(ZA,R1E,R2K,R3A),(ZA,R1E,R2K,R3B),
(ZA,R1E,R2K,R3C),(ZA,R1E,R2K,R3D),(ZA,R1E,R2K,R3E),
(ZA,R1E,R2K,R3F),(ZA,R1E,R2K,R3G),(ZA,R1E,R2K,R3H),
(ZA,R1E,R2K,R3I),(ZA,R1E,R2K,R3J),(ZA,R1E,R2K,R3K),
(ZA,R1E,R2K,R3L),(ZA,R1E,R2K,R3M),(ZA,R1E,R2K,R3N),
(ZA,R1E,R2K,R3O),(ZA,R1E,R2K,R3P),(ZA,R1E,R2K,R3Q),
(ZA,R1E,R2K,R3R),(ZA,R1E,R2L,R3A),(ZA,R1E,R2L,R3B),
(ZA,R1E,R2L,R3C),(ZA,R1E,R2L,R3D),(ZA,R1E,R2L,R3E),
(ZA,R1E,R2L,R3F),(ZA,R1E,R2L,R3G),(ZA,R1E,R2L,R3H),
(ZA,R1E,R2L,R3I),(ZA,R1E,R2L,R3J),(ZA,R1E,R2L,R3K),
(ZA,R1E,R2L,R3L),(ZA,R1E,R2L,R3M),(ZA,R1E,R2L,R3N),
(ZA,R1E,R2L,R3O),(ZA,R1E,R2L,R3P),(ZA,R1E,R2L,R3Q),
(ZA,R1E,R2L,R3R),(ZA,R1E,R2M,R3A),(ZA,R1E,R2M,R3B),
(ZA,R1E,R2M,R3C),(ZA,R1E,R2M,R3D),(ZA,R1E,R2M,R3E),
(ZA,R1E,R2M,R3F),(ZA,R1E,R2M,R3G),(ZA,R1E,R2M,R3H),
(ZA,R1E,R2M,R3I),(ZA,R1E,R2M,R3J),(ZA,R1E,R2M,R3K),
(ZA,R1E,R2M,R3L),(ZA,R1E,R2M,R3M),(ZA,R1E,R2M,R3N),
(ZA,R1E,R2M,R3O),(ZA,R1E,R2M,R3P),(ZA,R1E,R2M,R3Q),
(ZA,R1E,R2M,R3R),(ZA,R1E,R2N,R3A),(ZA,R1E,R2N,R3B),
(ZA,R1E,R2N,R3C),(ZA,R1E,R2N,R3D),(ZA,R1E,R2N,R3E),
(ZA,R1E,R2N,R3F),(ZA,R1E,R2N,R3G),(ZA,R1E,R2N,R3H),
(ZA,R1E,R2N,R3I),(ZA,R1E,R2N,R3J),(ZA,R1E,R2N,R3K),
(ZA,R1E,R2N,R3L),(ZA,R1E,R2N,R3M),(ZA,R1E,R2N,R3N),
(ZA,R1E,R2N,R3O),(ZA,R1E,R2N,R3P),(ZA,R1E,R2N,R3Q),
(ZA,R1E,R2N,R3R),(ZA,R1F,R2A,R3A),(ZA,R1F,R2A,R3B),
(ZA,R1F,R2A,R3C),(ZA,R1F,R2A,R3D),(ZA,R1F,R2A,R3E),
(ZA,R1F,R2A,R3F),(ZA,R1F,R2A,R3G),(ZA,R1F,R2A,R3H),
(ZA,R1F,R2A,R3I),(ZA,R1F,R2A,R3J),(ZA,R1F,R2A,R3K),
(ZA,R1F,R2A,R3L),(ZA,R1F,R2A,R3M),(ZA,R1F,R2A,R3N),
(ZA,R1F,R2A,R3O),(ZA,R1F,R2A,R3P),(ZA,R1F,R2A,R3Q),
(ZA,R1F,R2A,R3R),(ZA,R1F,R2B,R3A),(ZA,R1F,R2B,R3B),
(ZA,R1F,R2B,R3C),(ZA,R1F,R2B,R3D),(ZA,R1F,R2B,R3E),
(ZA,R1F,R2B,R3F),(ZA,R1F,R2B,R3G),(ZA,R1F,R2B,R3H),
(ZA,R1F,R2B,R3I),(ZA,R1F,R2B,R3J),(ZA,R1F,R2B,R3K),
(ZA,R1F,R2B,R3L),(ZA,R1F,R2B,R3M),(ZA,R1F,R2B,R3N),
(ZA,R1F,R2B,R3O),(ZA,R1F,R2B,R3P),(ZA,R1F,R2B,R3Q),
(ZA,R1F,R2B,R3R),(ZA,R1F,R2C,R3A),(ZA,R1F,R2C,R3B),
(ZA,R1F,R2C,R3C),(ZA,R1F,R2C,R3D),(ZA,R1F,R2C,R3E),
(ZA,R1F,R2C,R3F),(ZA,R1F,R2C,R3G),(ZA,R1F,R2C,R3H),
(ZA,R1F,R2C,R3I),(ZA,R1F,R2C,R3J),(ZA,R1F,R2C,R3K),
(ZA,R1F,R2C,R3L),(ZA,R1F,R2C,R3M),(ZA,R1F,R2C,R3N),
(ZA,R1F,R2C,R3O),(ZA,R1F,R2C,R3P),(ZA,R1F,R2C,R3Q),
(ZA,R1F,R2C,R3R),(ZA,R1F,R2D,R3A),(ZA,R1F,R2D,R3B),
(ZA,R1F,R2D,R3C),(ZA,R1F,R2D,R3D),(ZA,R1F,R2D,R3E),
(ZA,R1F,R2D,R3F),(ZA,R1F,R2D,R3G),(ZA,R1F,R2D,R3H),
(ZA,R1F,R2D,R3I),(ZA,R1F,R2D,R3J),(ZA,R1F,R2D,R3K),
(ZA,R1F,R2D,R3L),(ZA,R1F,R2D,R3M),(ZA,R1F,R2D,R3N),
(ZA,R1F,R2D,R3O),(ZA,R1F,R2D,R3P),(ZA,R1F,R2D,R3Q),
(ZA,R1F,R2D,R3R),(ZA,R1F,R2E,R3A),(ZA,R1F,R2E,R3B),
(ZA,R1F,R2E,R3C),(ZA,R1F,R2E,R3D),(ZA,R1F,R2E,R3E),
(ZA,R1F,R2E,R3F),(ZA,R1F,R2E,R3G),(ZA,R1F,R2E,R3H),
(ZA,R1F,R2E,R3I),(ZA,R1F,R2E,R3J),(ZA,R1F,R2E,R3K),
(ZA,R1F,R2E,R3L),(ZA,R1F,R2E,R3M),(ZA,R1F,R2E,R3N),
(ZA,R1F,R2E,R3O),(ZA,R1F,R2E,R3P),(ZA,R1F,R2E,R3Q),
(ZA,R1F,R2E,R3R),(ZA,R1F,R2F,R3A),(ZA,R1F,R2F,R3B),
(ZA,R1F,R2F,R3C),(ZA,R1F,R2F,R3D),(ZA,R1F,R2F,R3E),
(ZA,R1F,R2F,R3F),(ZA,R1F,R2F,R3G),(ZA,R1F,R2F,R3H),
(ZA,R1F,R2F,R3I),(ZA,R1F,R2F,R3J),(ZA,R1F,R2F,R3K),
(ZA,R1F,R2F,R3L),(ZA,R1F,R2F,R3M),(ZA,R1F,R2F,R3N),
(ZA,R1F,R2F,R3O),(ZA,R1F,R2F,R3P),(ZA,R1F,R2F,R3Q),
(ZA,R1F,R2F,R3R),(ZA,R1F,R2G,R3A),(ZA,R1F,R2G,R3B),
(ZA,R1F,R2G,R3C),(ZA,R1F,R2G,R3D),(ZA,R1F,R2G,R3E),
(ZA,R1F,R2G,R3F),(ZA,R1F,R2G,R3G),(ZA,R1F,R2G,R3H),
(ZA,R1F,R2G,R3I),(ZA,R1F,R2G,R3J),(ZA,R1F,R2G,R3K),
(ZA,R1F,R2G,R3L),(ZA,R1F,R2G,R3M),(ZA,R1F,R2G,R3N),
(ZA,R1F,R2G,R3O),(ZA,R1F,R2G,R3P),(ZA,R1F,R2G,R3Q),
(ZA,R1F,R2G,R3R),(ZA,R1F,R2H,R3A),(ZA,R1F,R2H,R3B),
(ZA,R1F,R2H,R3C),(ZA,R1F,R2H,R3D),(ZA,R1F,R2H,R3E),
(ZA,R1F,R2H,R3F),(ZA,R1F,R2H,R3G),(ZA,R1F,R2H,R3H),
(ZA,R1F,R2H,R3I),(ZA,R1F,R2H,R3J),(ZA,R1F,R2H,R3K),
(ZA,R1F,R2H,R3L),(ZA,R1F,R2H,R3M),(ZA,R1F,R2H,R3N),
(ZA,R1F,R2H,R3O),(ZA,R1F,R2H,R3P),(ZA,R1F,R2H,R3Q),
(ZA,R1F,R2H,R3R),(ZA,R1F,R2I,R3A),(ZA,R1F,R2I,R3B),
(ZA,R1F,R2I,R3C),(ZA,R1F,R2I,R3D),(ZA,R1F,R2I,R3E),
(ZA,R1F,R2I,R3F),(ZA,R1F,R2I,R3G),(ZA,R1F,R2I,R3H),
(ZA,R1F,R2I,R3I),(ZA,R1F,R2I,R3J),(ZA,R1F,R2I,R3K),
(ZA,R1F,R2I,R3L),(ZA,R1F,R2I,R3M),(ZA,R1F,R2I,R3N),
(ZA,R1F,R2I,R3O),(ZA,R1F,R2I,R3P),(ZA,R1F,R2I,R3Q),
(ZA,R1F,R2I,R3R),(ZA,R1F,R2J,R3A),(ZA,R1F,R2J,R3B),
(ZA,R1F,R2J,R3C),(ZA,R1F,R2J,R3D),(ZA,R1F,R2J,R3E),
(ZA,R1F,R2J,R3F),(ZA,R1F,R2J,R3G),(ZA,R1F,R2J,R3H),
(ZA,R1F,R2J,R3I),(ZA,R1F,R2J,R3J),(ZA,R1F,R2J,R3K),
(ZA,R1F,R2J,R3L),(ZA,R1F,R2J,R3M),(ZA,R1F,R2J,R3N),
(ZA,R1F,R2J,R3O),(ZA,R1F,R2J,R3P),(ZA,R1F,R2J,R3Q),
(ZA,R1F,R2J,R3R),(ZA,R1F,R2K,R3A),(ZA,R1F,R2K,R3B),
(ZA,R1F,R2K,R3C),(ZA,R1F,R2K,R3D),(ZA,R1F,R2K,R3E),
(ZA,R1F,R2K,R3F),(ZA,R1F,R2K,R3G),(ZA,R1F,R2K,R3H),
(ZA,R1F,R2K,R3I),(ZA,R1F,R2K,R3J),(ZA,R1F,R2K,R3K),
(ZA,R1F,R2K,R3L),(ZA,R1F,R2K,R3M),(ZA,R1F,R2K,R3N),
(ZA,R1F,R2K,R3O),(ZA,R1F,R2K,R3P),(ZA,R1F,R2K,R3Q),
(ZA,R1F,R2K,R3R),(ZA,R1F,R2L,R3A),(ZA,R1F,R2L,R3B),
(ZA,R1F,R2L,R3C),(ZA,R1F,R2L,R3D),(ZA,R1F,R2L,R3E),
(ZA,R1F,R2L,R3F),(ZA,R1F,R2L,R3G),(ZA,R1F,R2L,R3H),
(ZA,R1F,R2L,R3I),(ZA,R1F,R2L,R3J),(ZA,R1F,R2L,R3K),
(ZA,R1F,R2L,R3L),(ZA,R1F,R2L,R3M),(ZA,R1F,R2L,R3N),
(ZA,R1F,R2L,R3O),(ZA,R1F,R2L,R3P),(ZA,R1F,R2L,R3Q),
(ZA,R1F,R2L,R3R),(ZA,R1F,R2M,R3A),(ZA,R1F,R2M,R3B),
(ZA,R1F,R2M,R3C),(ZA,R1F,R2M,R3D),(ZA,R1F,R2M,R3E),
(ZA,R1F,R2M,R3F),(ZA,R1F,R2M,R3G),(ZA,R1F,R2M,R3H),
(ZA,R1F,R2M,R3I),(ZA,R1F,R2M,R3J),(ZA,R1F,R2M,R3K),
(ZA,R1F,R2M,R3L),(ZA,R1F,R2M,R3M),(ZA,R1F,R2M,R3N),
(ZA,R1F,R2M,R3O),(ZA,R1F,R2M,R3P),(ZA,R1F,R2M,R3Q),
(ZA,R1F,R2M,R3R),(ZA,R1F,R2N,R3A),(ZA,R1F,R2N,R3B),
(ZA,R1F,R2N,R3C),(ZA,R1F,R2N,R3D),(ZA,R1F,R2N,R3E),
(ZA,R1F,R2N,R3F),(ZA,R1F,R2N,R3G),(ZA,R1F,R2N,R3H),
(ZA,R1F,R2N,R3I),(ZA,R1F,R2N,R3J),(ZA,R1F,R2N,R3K),
(ZA,R1F,R2N,R3L),(ZA,R1F,R2N,R3M),(ZA,R1F,R2N,R3N),
(ZA,R1F,R2N,R3O),(ZA,R1F,R2N,R3P),(ZA,R1F,R2N,R3Q),
(ZA,R1F,R2N,R3R),(ZA,R1G,R2A,R3A),(ZA,R1G,R2A,R3B),
(ZA,R1G,R2A,R3C),(ZA,R1G,R2A,R3D),(ZA,R1G,R2A,R3E),
(ZA,R1G,R2A,R3F),(ZA,R1G,R2A,R3G),(ZA,R1G,R2A,R3H),
(ZA,R1G,R2A,R3I),(ZA,R1G,R2A,R3J),(ZA,R1G,R2A,R3K),
(ZA,R1G,R2A,R3L),(ZA,R1G,R2A,R3M),(ZA,R1G,R2A,R3N),
(ZA,R1G,R2A,R3O),(ZA,R1G,R2A,R3P),(ZA,R1G,R2A,R3Q),
(ZA,R1G,R2A,R3R),(ZA,R1G,R2B,R3A),(ZA,R1G,R2B,R3B),
(ZA,R1G,R2B,R3C),(ZA,R1G,R2B,R3D),(ZA,R1G,R2B,R3E),
(ZA,R1G,R2B,R3F),(ZA,R1G,R2B,R3G),(ZA,R1G,R2B,R3H),
(ZA,R1G,R2B,R3I),(ZA,R1G,R2B,R3J),(ZA,R1G,R2B,R3K),
(ZA,R1G,R2B,R3L),(ZA,R1G,R2B,R3M),(ZA,R1G,R2B,R3N),
(ZA,R1G,R2B,R3O),(ZA,R1G,R2B,R3P),(ZA,R1G,R2B,R3Q),
(ZA,R1G,R2B,R3R),(ZA,R1G,R2C,R3A),(ZA,R1G,R2C,R3B),
(ZA,R1G,R2C,R3C),(ZA,R1G,R2C,R3D),(ZA,R1G,R2C,R3E),
(ZA,R1G,R2C,R3F),(ZA,R1G,R2C,R3G),(ZA,R1G,R2C,R3H),
(ZA,R1G,R2C,R3I),(ZA,R1G,R2C,R3J),(ZA,R1G,R2C,R3K),
(ZA,R1G,R2C,R3L),(ZA,R1G,R2C,R3M),(ZA,R1G,R2C,R3N),
(ZA,R1G,R2C,R3O),(ZA,R1G,R2C,R3P),(ZA,R1G,R2C,R3Q),
(ZA,R1G,R2C,R3R),(ZA,R1G,R2D,R3A),(ZA,R1G,R2D,R3B),
(ZA,R1G,R2D,R3C),(ZA,R1G,R2D,R3D),(ZA,R1G,R2D,R3E),
(ZA,R1G,R2D,R3F),(ZA,R1G,R2D,R3G),(ZA,R1G,R2D,R3H),
(ZA,R1G,R2D,R3I),(ZA,R1G,R2D,R3J),(ZA,R1G,R2D,R3K),
(ZA,R1G,R2D,R3L),(ZA,R1G,R2D,R3M),(ZA,R1G,R2D,R3N),
(ZA,R1G,R2D,R3O),(ZA,R1G,R2D,R3P),(ZA,R1G,R2D,R3Q),
(ZA,R1G,R2D,R3R),(ZA,R1G,R2E,R3A),(ZA,R1G,R2E,R3B),
(ZA,R1G,R2E,R3C),(ZA,R1G,R2E,R3D),(ZA,R1G,R2E,R3E),
(ZA,R1G,R2E,R3F),(ZA,R1G,R2E,R3G),(ZA,R1G,R2E,R3H),
(ZA,R1G,R2E,R3I),(ZA,R1G,R2E,R3J),(ZA,R1G,R2E,R3K),
(ZA,R1G,R2E,R3L),(ZA,R1G,R2E,R3M),(ZA,R1G,R2E,R3N),
(ZA,R1G,R2E,R3O),(ZA,R1G,R2E,R3P),(ZA,R1G,R2E,R3Q),
(ZA,R1G,R2E,R3R),(ZA,R1G,R2F,R3A),(ZA,R1G,R2F,R3B),
(ZA,R1G,R2F,R3C),(ZA,R1G,R2F,R3D),(ZA,R1G,R2F,R3E),
(ZA,R1G,R2F,R3F),(ZA,R1G,R2F,R3G),(ZA,R1G,R2F,R3H),
(ZA,R1G,R2F,R3I),(ZA,R1G,R2F,R3J),(ZA,R1G,R2F,R3K),
(ZA,R1G,R2F,R3L),(ZA,R1G,R2F,R3M),(ZA,R1G,R2F,R3N),
(ZA,R1G,R2F,R3O),(ZA,R1G,R2F,R3P),(ZA,R1G,R2F,R3Q),
(ZA,R1G,R2F,R3R),(ZA,R1G,R2G,R3A),(ZA,R1G,R2G,R3B),
(ZA,R1G,R2G,R3C),(ZA,R1G,R2G,R3D),(ZA,R1G,R2G,R3E),
(ZA,R1G,R2G,R3F),(ZA,R1G,R2G,R3G),(ZA,R1G,R2G,R3H),
(ZA,R1G,R2G,R3I),(ZA,R1G,R2G,R3J),(ZA,R1G,R2G,R3K),
(ZA,R1G,R2G,R3L),(ZA,R1G,R2G,R3M),(ZA,R1G,R2G,R3N),
(ZA,R1G,R2G,R3O),(ZA,R1G,R2G,R3P),(ZA,R1G,R2G,R3Q),
(ZA,R1G,R2G,R3R),(ZA,R1G,R2H,R3A),(ZA,R1G,R2H,R3B),
(ZA,R1G,R2H,R3C),(ZA,R1G,R2H,R3D),(ZA,R1G,R2H,R3E),
(ZA,R1G,R2H,R3F),(ZA,R1G,R2H,R3G),(ZA,R1G,R2H,R3H),
(ZA,R1G,R2H,R3I),(ZA,R1G,R2H,R3J),(ZA,R1G,R2H,R3K),
(ZA,R1G,R2H,R3L),(ZA,R1G,R2H,R3M),(ZA,R1G,R2H,R3N),
(ZA,R1G,R2H,R3O),(ZA,R1G,R2H,R3P),(ZA,R1G,R2H,R3Q),
(ZA,R1G,R2H,R3R),(ZA,R1G,R2I,R3A),(ZA,R1G,R2I,R3B),
(ZA,R1G,R2I,R3C),(ZA,R1G,R2I,R3D),(ZA,R1G,R2I,R3E),
(ZA,R1G,R2I,R3F),(ZA,R1G,R2I,R3G),(ZA,R1G,R2I,R3H),
(ZA,R1G,R2I,R3I),(ZA,R1G,R2I,R3J),(ZA,R1G,R2I,R3K),
(ZA,R1G,R2I,R3L),(ZA,R1G,R2I,R3M),(ZA,R1G,R2I,R3N),
(ZA,R1G,R2I,R3O),(ZA,R1G,R2I,R3P),(ZA,R1G,R2I,R3Q),
(ZA,R1G,R2I,R3R),(ZA,R1G,R2J,R3A),(ZA,R1G,R2J,R3B),
(ZA,R1G,R2J,R3C),(ZA,R1G,R2J,R3D),(ZA,R1G,R2J,R3E),
(ZA,R1G,R2J,R3F),(ZA,R1G,R2J,R3G),(ZA,R1G,R2J,R3H),
(ZA,R1G,R2J,R3I),(ZA,R1G,R2J,R3J),(ZA,R1G,R2J,R3K),
(ZA,R1G,R2J,R3L),(ZA,R1G,R2J,R3M),(ZA,R1G,R2J,R3N),
(ZA,R1G,R2J,R3O),(ZA,R1G,R2J,R3P),(ZA,R1G,R2J,R3Q),
(ZA,R1G,R2J,R3R),(ZA,R1G,R2K,R3A),(ZA,R1G,R2K,R3B),
(ZA,R1G,R2K,R3C),(ZA,R1G,R2K,R3D),(ZA,R1G,R2K,R3E),
(ZA,R1G,R2K,R3F),(ZA,R1G,R2K,R3G),(ZA,R1G,R2K,R3H),
(ZA,R1G,R2K,R3I),(ZA,R1G,R2K,R3J),(ZA,R1G,R2K,R3K),
(ZA,R1G,R2K,R3L),(ZA,R1G,R2K,R3M),(ZA,R1G,R2K,R3N),
(ZA,R1G,R2K,R3O),(ZA,R1G,R2K,R3P),(ZA,R1G,R2K,R3Q),
(ZA,R1G,R2K,R3R),(ZA,R1G,R2L,R3A),(ZA,R1G,R2L,R3B),
(ZA,R1G,R2L,R3C),(ZA,R1G,R2L,R3D),(ZA,R1G,R2L,R3E),
(ZA,R1G,R2L,R3F),(ZA,R1G,R2L,R3G),(ZA,R1G,R2L,R3H),
(ZA,R1G,R2L,R3I),(ZA,R1G,R2L,R3J),(ZA,R1G,R2L,R3K),
(ZA,R1G,R2L,R3L),(ZA,R1G,R2L,R3M),(ZA,R1G,R2L,R3N),
(ZA,R1G,R2L,R3O),(ZA,R1G,R2L,R3P),(ZA,R1G,R2L,R3Q),
(ZA,R1G,R2L,R3R),(ZA,R1G,R2M,R3A),(ZA,R1G,R2M,R3B),
(ZA,R1G,R2M,R3C),(ZA,R1G,R2M,R3D),(ZA,R1G,R2M,R3E),
(ZA,R1G,R2M,R3F),(ZA,R1G,R2M,R3G),(ZA,R1G,R2M,R3H),
(ZA,R1G,R2M,R3I),(ZA,R1G,R2M,R3J),(ZA,R1G,R2M,R3K),
(ZA,R1G,R2M,R3L),(ZA,R1G,R2M,R3M),(ZA,R1G,R2M,R3N),
(ZA,R1G,R2M,R3O),(ZA,R1G,R2M,R3P),(ZA,R1G,R2M,R3Q),
(ZA,R1G,R2M,R3R),(ZA,R1G,R2N,R3A),(ZA,R1G,R2N,R3B),
(ZA,R1G,R2N,R3C),(ZA,R1G,R2N,R3D),(ZA,R1G,R2N,R3E),
(ZA,R1G,R2N,R3F),(ZA,R1G,R2N,R3G),(ZA,R1G,R2N,R3H),
(ZA,R1G,R2N,R3I),(ZA,R1G,R2N,R3J),(ZA,R1G,R2N,R3K),
(ZA,R1G,R2N,R3L),(ZA,R1G,R2N,R3M),(ZA,R1G,R2N,R3N),
(ZA,R1G,R2N,R3O),(ZA,R1G,R2N,R3P),(ZA,R1G,R2N,R3Q),
(ZA,R1G,R2N,R3R),(ZA,R1H,R2A,R3A),(ZA,R1H,R2A,R3B),
(ZA,R1H,R2A,R3C),(ZA,R1H,R2A,R3D),(ZA,R1H,R2A,R3E),
(ZA,R1H,R2A,R3F),(ZA,R1H,R2A,R3G),(ZA,R1H,R2A,R3H),
(ZA,R1H,R2A,R3I),(ZA,R1H,R2A,R3J),(ZA,R1H,R2A,R3K),
(ZA,R1H,R2A,R3L),(ZA,R1H,R2A,R3M),(ZA,R1H,R2A,R3N),
(ZA,R1H,R2A,R3O),(ZA,R1H,R2A,R3P),(ZA,R1H,R2A,R3Q),
(ZA,R1H,R2A,R3R),(ZA,R1H,R2B,R3A),(ZA,R1H,R2B,R3B),
(ZA,R1H,R2B,R3C),(ZA,R1H,R2B,R3D),(ZA,R1H,R2B,R3E),
(ZA,R1H,R2B,R3F),(ZA,R1H,R2B,R3G),(ZA,R1H,R2B,R3H),
(ZA,R1H,R2B,R3I),(ZA,R1H,R2B,R3J),(ZA,R1H,R2B,R3K),
(ZA,R1H,R2B,R3L),(ZA,R1H,R2B,R3M),(ZA,R1H,R2B,R3N),
(ZA,R1H,R2B,R3O),(ZA,R1H,R2B,R3P),(ZA,R1H,R2B,R3Q),
(ZA,R1H,R2B,R3R),(ZA,R1H,R2C,R3A),(ZA,R1H,R2C,R3B),
(ZA,R1H,R2C,R3C),(ZA,R1H,R2C,R3D),(ZA,R1H,R2C,R3E),
(ZA,R1H,R2C,R3F),(ZA,R1H,R2C,R3G),(ZA,R1H,R2C,R3H),
(ZA,R1H,R2C,R3I),(ZA,R1H,R2C,R3J),(ZA,R1H,R2C,R3K),
(ZA,R1H,R2C,R3L),(ZA,R1H,R2C,R3M),(ZA,R1H,R2C,R3N),
(ZA,R1H,R2C,R3O),(ZA,R1H,R2C,R3P),(ZA,R1H,R2C,R3Q),
(ZA,R1H,R2C,R3R),(ZA,R1H,R2D,R3A),(ZA,R1H,R2D,R3B),
(ZA,R1H,R2D,R3C),(ZA,R1H,R2D,R3D),(ZA,R1H,R2D,R3E),
(ZA,R1H,R2D,R3F),(ZA,R1H,R2D,R3G),(ZA,R1H,R2D,R3H),
(ZA,R1H,R2D,R3I),(ZA,R1H,R2D,R3J),(ZA,R1H,R2D,R3K),
(ZA,R1H,R2D,R3L),(ZA,R1H,R2D,R3M),(ZA,R1H,R2D,R3N),
(ZA,R1H,R2D,R3O),(ZA,R1H,R2D,R3P),(ZA,R1H,R2D,R3Q),
(ZA,R1H,R2D,R3R),(ZA,R1H,R2E,R3A),(ZA,R1H,R2E,R3B),
(ZA,R1H,R2E,R3C),(ZA,R1H,R2E,R3D),(ZA,R1H,R2E,R3E),
(ZA,R1H,R2E,R3F),(ZA,R1H,R2E,R3G),(ZA,R1H,R2E,R3H),
(ZA,R1H,R2E,R3I),(ZA,R1H,R2E,R3J),(ZA,R1H,R2E,R3K),
(ZA,R1H,R2E,R3L),(ZA,R1H,R2E,R3M),(ZA,R1H,R2E,R3N),
(ZA,R1H,R2E,R3O),(ZA,R1H,R2E,R3P),(ZA,R1H,R2E,R3Q),
(ZA,R1H,R2E,R3R),(ZA,R1H,R2F,R3A),(ZA,R1H,R2F,R3B),
(ZA,R1H,R2F,R3C),(ZA,R1H,R2F,R3D),(ZA,R1H,R2F,R3E),
(ZA,R1H,R2F,R3F),(ZA,R1H,R2F,R3G),(ZA,R1H,R2F,R3H),
(ZA,R1H,R2F,R3I),(ZA,R1H,R2F,R3J),(ZA,R1H,R2F,R3K),
(ZA,R1H,R2F,R3L),(ZA,R1H,R2F,R3M),(ZA,R1H,R2F,R3N),
(ZA,R1H,R2F,R3O),(ZA,R1H,R2F,R3P),(ZA,R1H,R2F,R3Q),
(ZA,R1H,R2F,R3R),(ZA,R1H,R2G,R3A),(ZA,R1H,R2G,R3B),
(ZA,R1H,R2G,R3C),(ZA,R1H,R2G,R3D),(ZA,R1H,R2G,R3E),
(ZA,R1H,R2G,R3F),(ZA,R1H,R2G,R3G),(ZA,R1H,R2G,R3H),
(ZA,R1H,R2G,R3I),(ZA,R1H,R2G,R3J),(ZA,R1H,R2G,R3K),
(ZA,R1H,R2G,R3L),(ZA,R1H,R2G,R3M),(ZA,R1H,R2G,R3N),
(ZA,R1H,R2G,R3O),(ZA,R1H,R2G,R3P),(ZA,R1H,R2G,R3Q),
(ZA,R1H,R2G,R3R),(ZA,R1H,R2H,R3A),(ZA,R1H,R2H,R3B),
(ZA,R1H,R2H,R3C),(ZA,R1H,R2H,R3D),(ZA,R1H,R2H,R3E),
(ZA,R1H,R2H,R3F),(ZA,R1H,R2H,R3G),(ZA,R1H,R2H,R3H),
(ZA,R1H,R2H,R3I),(ZA,R1H,R2H,R3J),(ZA,R1H,R2H,R3K),
(ZA,R1H,R2H,R3L),(ZA,R1H,R2H,R3M),(ZA,R1H,R2H,R3N),
(ZA,R1H,R2H,R3O),(ZA,R1H,R2H,R3P),(ZA,R1H,R2H,R3Q),
(ZA,R1H,R2H,R3R),(ZA,R1H,R2I,R3A),(ZA,R1H,R2I,R3B),
(ZA,R1H,R2I,R3C),(ZA,R1H,R2I,R3D),(ZA,R1H,R2I,R3E),
(ZA,R1H,R2I,R3F),(ZA,R1H,R2I,R3G),(ZA,R1H,R2I,R3H),
(ZA,R1H,R2I,R3I),(ZA,R1H,R2I,R3J),(ZA,R1H,R2I,R3K),
(ZA,R1H,R2I,R3L),(ZA,R1H,R2I,R3M),(ZA,R1H,R2I,R3N),
(ZA,R1H,R2I,R3O),(ZA,R1H,R2I,R3P),(ZA,R1H,R2I,R3Q),
(ZA,R1H,R2I,R3R),(ZA,R1H,R2J,R3A),(ZA,R1H,R2J,R3B),
(ZA,R1H,R2J,R3C),(ZA,R1H,R2J,R3D),(ZA,R1H,R2J,R3E),
(ZA,R1H,R2J,R3F),(ZA,R1H,R2J,R3G),(ZA,R1H,R2J,R3H),
(ZA,R1H,R2J,R3I),(ZA,R1H,R2J,R3J),(ZA,R1H,R2J,R3K),
(ZA,R1H,R2J,R3L),(ZA,R1H,R2J,R3M),(ZA,R1H,R2J,R3N),
(ZA,R1H,R2J,R3O),(ZA,R1H,R2J,R3P),(ZA,R1H,R2J,R3Q),
(ZA,R1H,R2J,R3R),(ZA,R1H,R2K,R3A),(ZA,R1H,R2K,R3B),
(ZA,R1H,R2K,R3C),(ZA,R1H,R2K,R3D),(ZA,R1H,R2K,R3E),
(ZA,R1H,R2K,R3F),(ZA,R1H,R2K,R3G),(ZA,R1H,R2K,R3H),
(ZA,R1H,R2K,R3I),(ZA,R1H,R2K,R3J),(ZA,R1H,R2K,R3K),
(ZA,R1H,R2K,R3L),(ZA,R1H,R2K,R3M),(ZA,R1H,R2K,R3N),
(ZA,R1H,R2K,R3O),(ZA,R1H,R2K,R3P),(ZA,R1H,R2K,R3Q),
(ZA,R1H,R2K,R3R),(ZA,R1H,R2L,R3A),(ZA,R1H,R2L,R3B),
(ZA,R1H,R2L,R3C),(ZA,R1H,R2L,R3D),(ZA,R1H,R2L,R3E),
(ZA,R1H,R2L,R3F),(ZA,R1H,R2L,R3G),(ZA,R1H,R2L,R3H),
(ZA,R1H,R2L,R3I),(ZA,R1H,R2L,R3J),(ZA,R1H,R2L,R3K),
(ZA,R1H,R2L,R3L),(ZA,R1H,R2L,R3M),(ZA,R1H,R2L,R3N),
(ZA,R1H,R2L,R3O),(ZA,R1H,R2L,R3P),(ZA,R1H,R2L,R3Q),
(ZA,R1H,R2L,R3R),(ZA,R1H,R2M,R3A),(ZA,R1H,R2M,R3B),
(ZA,R1H,R2M,R3C),(ZA,R1H,R2M,R3D),(ZA,R1H,R2M,R3E),
(ZA,R1H,R2M,R3F),(ZA,R1H,R2M,R3G),(ZA,R1H,R2M,R3H),
(ZA,R1H,R2M,R3I),(ZA,R1H,R2M,R3J),(ZA,R1H,R2M,R3K),
(ZA,R1H,R2M,R3L),(ZA,R1H,R2M,R3M),(ZA,R1H,R2M,R3N),
(ZA,R1H,R2M,R3O),(ZA,R1H,R2M,R3P),(ZA,R1H,R2M,R3Q),
(ZA,R1H,R2M,R3R),(ZA,R1H,R2N,R3A),(ZA,R1H,R2N,R3B),
(ZA,R1H,R2N,R3C),(ZA,R1H,R2N,R3D),(ZA,R1H,R2N,R3E),
(ZA,R1H,R2N,R3F),(ZA,R1H,R2N,R3G),(ZA,R1H,R2N,R3H),
(ZA,R1H,R2N,R3I),(ZA,R1H,R2N,R3J),(ZA,R1H,R2N,R3K),
(ZA,R1H,R2N,R3L),(ZA,R1H,R2N,R3M),(ZA,R1H,R2N,R3N),
(ZA,R1H,R2N,R3O),(ZA,R1H,R2N,R3P),(ZA,R1H,R2N,R3Q),
(ZA,R1H,R2N,R3R),(ZA,R1I,R2A,R3A),(ZA,R1I,R2A,R3B),
(ZA,R1I,R2A,R3C),(ZA,R1I,R2A,R3D),(ZA,R1I,R2A,R3E),
(ZA,R1I,R2A,R3F),(ZA,R1I,R2A,R3G),(ZA,R1I,R2A,R3H),
(ZA,R1I,R2A,R3I),(ZA,R1I,R2A,R3J),(ZA,R1I,R2A,R3K),
(ZA,R1I,R2A,R3L),(ZA,R1I,R2A,R3M),(ZA,R1I,R2A,R3N),
(ZA,R1I,R2A,R3O),(ZA,R1I,R2A,R3P),(ZA,R1I,R2A,R3Q),
(ZA,R1I,R2A,R3R),(ZA,R1I,R2B,R3A),(ZA,R1I,R2B,R3B),
(ZA,R1I,R2B,R3C),(ZA,R1I,R2B,R3D),(ZA,R1I,R2B,R3E),
(ZA,R1I,R2B,R3F),(ZA,R1I,R2B,R3G),(ZA,R1I,R2B,R3H),
(ZA,R1I,R2B,R3I),(ZA,R1I,R2B,R3J),(ZA,R1I,R2B,R3K),
(ZA,R1I,R2B,R3L),(ZA,R1I,R2B,R3M),(ZA,R1I,R2B,R3N),
(ZA,R1I,R2B,R3O),(ZA,R1I,R2B,R3P),(ZA,R1I,R2B,R3Q),
(ZA,R1I,R2B,R3R),(ZA,R1I,R2C,R3A),(ZA,R1I,R2C,R3B),
(ZA,R1I,R2C,R3C),(ZA,R1I,R2C,R3D),(ZA,R1I,R2C,R3E),
(ZA,R1I,R2C,R3F),(ZA,R1I,R2C,R3G),(ZA,R1I,R2C,R3H),
(ZA,R1I,R2C,R3I),(ZA,R1I,R2C,R3J),(ZA,R1I,R2C,R3K),
(ZA,R1I,R2C,R3L),(ZA,R1I,R2C,R3M),(ZA,R1I,R2C,R3N),
(ZA,R1I,R2C,R3O),(ZA,R1I,R2C,R3P),(ZA,R1I,R2C,R3Q),
(ZA,R1I,R2C,R3R),(ZA,R1I,R2D,R3A),(ZA,R1I,R2D,R3B),
(ZA,R1I,R2D,R3C),(ZA,R1I,R2D,R3D),(ZA,R1I,R2D,R3E),
(ZA,R1I,R2D,R3F),(ZA,R1I,R2D,R3G),(ZA,R1I,R2D,R3H),
(ZA,R1I,R2D,R3I),(ZA,R1I,R2D,R3J),(ZA,R1I,R2D,R3K),
(ZA,R1I,R2D,R3L),(ZA,R1I,R2D,R3M),(ZA,R1I,R2D,R3N),
(ZA,R1I,R2D,R3O),(ZA,R1I,R2D,R3P),(ZA,R1I,R2D,R3Q),
(ZA,R1I,R2D,R3R),(ZA,R1I,R2E,R3A),(ZA,R1I,R2E,R3B),
(ZA,R1I,R2E,R3C),(ZA,R1I,R2E,R3D),(ZA,R1I,R2E,R3E),
(ZA,R1I,R2E,R3F),(ZA,R1I,R2E,R3G),(ZA,R1I,R2E,R3H),
(ZA,R1I,R2E,R3I),(ZA,R1I,R2E,R3J),(ZA,R1I,R2E,R3K),
(ZA,R1I,R2E,R3L),(ZA,R1I,R2E,R3M),(ZA,R1I,R2E,R3N),
(ZA,R1I,R2E,R3O),(ZA,R1I,R2E,R3P),(ZA,R1I,R2E,R3Q),
(ZA,R1I,R2E,R3R),(ZA,R1I,R2F,R3A),(ZA,R1I,R2F,R3B),
(ZA,R1I,R2F,R3C),(ZA,R1I,R2F,R3D),(ZA,R1I,R2F,R3E),
(ZA,R1I,R2F,R3F),(ZA,R1I,R2F,R3G),(ZA,R1I,R2F,R3H),
(ZA,R1I,R2F,R3I),(ZA,R1I,R2F,R3J),(ZA,R1I,R2F,R3K),
(ZA,R1I,R2F,R3L),(ZA,R1I,R2F,R3M),(ZA,R1I,R2F,R3N),
(ZA,R1I,R2F,R3O),(ZA,R1I,R2F,R3P),(ZA,R1I,R2F,R3Q),
(ZA,R1I,R2F,R3R),(ZA,R1I,R2G,R3A),(ZA,R1I,R2G,R3B),
(ZA,R1I,R2G,R3C),(ZA,R1I,R2G,R3D),(ZA,R1I,R2G,R3E),
(ZA,R1I,R2G,R3F),(ZA,R1I,R2G,R3G),(ZA,R1I,R2G,R3H),
(ZA,R1I,R2G,R3I),(ZA,R1I,R2G,R3J),(ZA,R1I,R2G,R3K),
(ZA,R1I,R2G,R3L),(ZA,R1I,R2G,R3M),(ZA,R1I,R2G,R3N),
(ZA,R1I,R2G,R3O),(ZA,R1I,R2G,R3P),(ZA,R1I,R2G,R3Q),
(ZA,R1I,R2G,R3R),(ZA,R1I,R2H,R3A),(ZA,R1I,R2H,R3B),
(ZA,R1I,R2H,R3C),(ZA,R1I,R2H,R3D),(ZA,R1I,R2H,R3E),
(ZA,R1I,R2H,R3F),(ZA,R1I,R2H,R3G),(ZA,R1I,R2H,R3H),
(ZA,R1I,R2H,R3I),(ZA,R1I,R2H,R3J),(ZA,R1I,R2H,R3K),
(ZA,R1I,R2H,R3L),(ZA,R1I,R2H,R3M),(ZA,R1I,R2H,R3N),
(ZA,R1I,R2H,R3O),(ZA,R1I,R2H,R3P),(ZA,R1I,R2H,R3Q),
(ZA,R1I,R2H,R3R),(ZA,R1I,R2I,R3A),(ZA,R1I,R2I,R3B),
(ZA,R1I,R2I,R3C),(ZA,R1I,R2I,R3D),(ZA,R1I,R2I,R3E),
(ZA,R1I,R2I,R3F),(ZA,R1I,R2I,R3G),(ZA,R1I,R2I,R3H),
(ZA,R1I,R2I,R3I),(ZA,R1I,R2I,R3J),(ZA,R1I,R2I,R3K),
(ZA,R1I,R2I,R3L),(ZA,R1I,R2I,R3M),(ZA,R1I,R2I,R3N),
(ZA,R1I,R2I,R3O),(ZA,R1I,R2I,R3P),(ZA,R1I,R2I,R3Q),
(ZA,R1I,R2I,R3R),(ZA,R1I,R2J,R3A),(ZA,R1I,R2J,R3B),
(ZA,R1I,R2J,R3C),(ZA,R1I,R2J,R3D),(ZA,R1I,R2J,R3E),
(ZA,R1I,R2J,R3F),(ZA,R1I,R2J,R3G),(ZA,R1I,R2J,R3H),
(ZA,R1I,R2J,R3I),(ZA,R1I,R2J,R3J),(ZA,R1I,R2J,R3K),
(ZA,R1I,R2J,R3L),(ZA,R1I,R2J,R3M),(ZA,R1I,R2J,R3N),
(ZA,R1I,R2J,R3O),(ZA,R1I,R2J,R3P),(ZA,R1I,R2J,R3Q),
(ZA,R1I,R2J,R3R),(ZA,R1I,R2K,R3A),(ZA,R1I,R2K,R3B),
(ZA,R1I,R2K,R3C),(ZA,R1I,R2K,R3D),(ZA,R1I,R2K,R3E),
(ZA,R1I,R2K,R3F),(ZA,R1I,R2K,R3G),(ZA,R1I,R2K,R3H),
(ZA,R1I,R2K,R3I),(ZA,R1I,R2K,R3J),(ZA,R1I,R2K,R3K),
(ZA,R1I,R2K,R3L),(ZA,R1I,R2K,R3M),(ZA,R1I,R2K,R3N),
(ZA,R1I,R2K,R3O),(ZA,R1I,R2K,R3P),(ZA,R1I,R2K,R3Q),
(ZA,R1I,R2K,R3R),(ZA,R1I,R2L,R3A),(ZA,R1I,R2L,R3B),
(ZA,R1I,R2L,R3C),(ZA,R1I,R2L,R3D),(ZA,R1I,R2L,R3E),
(ZA,R1I,R2L,R3F),(ZA,R1I,R2L,R3G),(ZA,R1I,R2L,R3H),
(ZA,R1I,R2L,R3I),(ZA,R1I,R2L,R3J),(ZA,R1I,R2L,R3K),
(ZA,R1I,R2L,R3L),(ZA,R1I,R2L,R3M),(ZA,R1I,R2L,R3N),
(ZA,R1I,R2L,R3O),(ZA,R1I,R2L,R3P),(ZA,R1I,R2L,R3Q),
(ZA,R1I,R2L,R3R),(ZA,R1I,R2M,R3A),(ZA,R1I,R2M,R3B),
(ZA,R1I,R2M,R3C),(ZA,R1I,R2M,R3D),(ZA,R1I,R2M,R3E),
(ZA,R1I,R2M,R3F),(ZA,R1I,R2M,R3G),(ZA,R1I,R2M,R3H),
(ZA,R1I,R2M,R3I),(ZA,R1I,R2M,R3J),(ZA,R1I,R2M,R3K),
(ZA,R1I,R2M,R3L),(ZA,R1I,R2M,R3M),(ZA,R1I,R2M,R3N),
(ZA,R1I,R2M,R3O),(ZA,R1I,R2M,R3P),(ZA,R1I,R2M,R3Q),
(ZA,R1I,R2M,R3R),(ZA,R1I,R2N,R3A),(ZA,R1I,R2N,R3B),
(ZA,R1I,R2N,R3C),(ZA,R1I,R2N,R3D),(ZA,R1I,R2N,R3E),
(ZA,R1I,R2N,R3F),(ZA,R1I,R2N,R3G),(ZA,R1I,R2N,R3H),
(ZA,R1I,R2N,R3I),(ZA,R1I,R2N,R3J),(ZA,R1I,R2N,R3K),
(ZA,R1I,R2N,R3L),(ZA,R1I,R2N,R3M),(ZA,R1I,R2N,R3N),
(ZA,R1I,R2N,R3O),(ZA,R1I,R2N,R3P),(ZA,R1I,R2N,R3Q),
(ZA,R1I,R2N,R3R),(ZA,R1J,R2A,R3A),(ZA,R1J,R2A,R3B),
(ZA,R1J,R2A,R3C),(ZA,R1J,R2A,R3D),(ZA,R1J,R2A,R3E),
(ZA,R1J,R2A,R3F),(ZA,R1J,R2A,R3G),(ZA,R1J,R2A,R3H),
(ZA,R1J,R2A,R3I),(ZA,R1J,R2A,R3J),(ZA,R1J,R2A,R3K),
(ZA,R1J,R2A,R3L),(ZA,R1J,R2A,R3M),(ZA,R1J,R2A,R3N),
(ZA,R1J,R2A,R3O),(ZA,R1J,R2A,R3P),(ZA,R1J,R2A,R3Q),
(ZA,R1J,R2A,R3R),(ZA,R1J,R2B,R3A),(ZA,R1J,R2B,R3B),
(ZA,R1J,R2B,R3C),(ZA,R1J,R2B,R3D),(ZA,R1J,R2B,R3E),
(ZA,R1J,R2B,R3F),(ZA,R1J,R2B,R3G),(ZA,R1J,R2B,R3H),
(ZA,R1J,R2B,R3I),(ZA,R1J,R2B,R3J),(ZA,R1J,R2B,R3K),
(ZA,R1J,R2B,R3L),(ZA,R1J,R2B,R3M),(ZA,R1J,R2B,R3N),
(ZA,R1J,R2B,R3O),(ZA,R1J,R2B,R3P),(ZA,R1J,R2B,R3Q),
(ZA,R1J,R2B,R3R),(ZA,R1J,R2C,R3A),(ZA,R1J,R2C,R3B),
(ZA,R1J,R2C,R3C),(ZA,R1J,R2C,R3D),(ZA,R1J,R2C,R3E),
(ZA,R1J,R2C,R3F),(ZA,R1J,R2C,R3G),(ZA,R1J,R2C,R3H),
(ZA,R1J,R2C,R3I),(ZA,R1J,R2C,R3J),(ZA,R1J,R2C,R3K),
(ZA,R1J,R2C,R3L),(ZA,R1J,R2C,R3M),(ZA,R1J,R2C,R3N),
(ZA,R1J,R2C,R3O),(ZA,R1J,R2C,R3P),(ZA,R1J,R2C,R3Q),
(ZA,R1J,R2C,R3R),(ZA,R1J,R2D,R3A),(ZA,R1J,R2D,R3B),
(ZA,R1J,R2D,R3C),(ZA,R1J,R2D,R3D),(ZA,R1J,R2D,R3E),
(ZA,R1J,R2D,R3F),(ZA,R1J,R2D,R3G),(ZA,R1J,R2D,R3H),
(ZA,R1J,R2D,R3I),(ZA,R1J,R2D,R3J),(ZA,R1J,R2D,R3K),
(ZA,R1J,R2D,R3L),(ZA,R1J,R2D,R3M),(ZA,R1J,R2D,R3N),
(ZA,R1J,R2D,R3O),(ZA,R1J,R2D,R3P),(ZA,R1J,R2D,R3Q),
(ZA,R1J,R2D,R3R),(ZA,R1J,R2E,R3A),(ZA,R1J,R2E,R3B),
(ZA,R1J,R2E,R3C),(ZA,R1J,R2E,R3D),(ZA,R1J,R2E,R3E),
(ZA,R1J,R2E,R3F),(ZA,R1J,R2E,R3G),(ZA,R1J,R2E,R3H),
(ZA,R1J,R2E,R3I),(ZA,R1J,R2E,R3J),(ZA,R1J,R2E,R3K),
(ZA,R1J,R2E,R3L),(ZA,R1J,R2E,R3M),(ZA,R1J,R2E,R3N),
(ZA,R1J,R2E,R3O),(ZA,R1J,R2E,R3P),(ZA,R1J,R2E,R3Q),
(ZA,R1J,R2E,R3R),(ZA,R1J,R2F,R3A),(ZA,R1J,R2F,R3B),
(ZA,R1J,R2F,R3C),(ZA,R1J,R2F,R3D),(ZA,R1J,R2F,R3E),
(ZA,R1J,R2F,R3F),(ZA,R1J,R2F,R3G),(ZA,R1J,R2F,R3H),
(ZA,R1J,R2F,R3I),(ZA,R1J,R2F,R3J),(ZA,R1J,R2F,R3K),
(ZA,R1J,R2F,R3L),(ZA,R1J,R2F,R3M),(ZA,R1J,R2F,R3N),
(ZA,R1J,R2F,R3O),(ZA,R1J,R2F,R3P),(ZA,R1J,R2F,R3Q),
(ZA,R1J,R2F,R3R),(ZA,R1J,R2G,R3A),(ZA,R1J,R2G,R3B),
(ZA,R1J,R2G,R3C),(ZA,R1J,R2G,R3D),(ZA,R1J,R2G,R3E),
(ZA,R1J,R2G,R3F),(ZA,R1J,R2G,R3G),(ZA,R1J,R2G,R3H),
(ZA,R1J,R2G,R3I),(ZA,R1J,R2G,R3J),(ZA,R1J,R2G,R3K),
(ZA,R1J,R2G,R3L),(ZA,R1J,R2G,R3M),(ZA,R1J,R2G,R3N),
(ZA,R1J,R2G,R3O),(ZA,R1J,R2G,R3P),(ZA,R1J,R2G,R3Q),
(ZA,R1J,R2G,R3R),(ZA,R1J,R2H,R3A),(ZA,R1J,R2H,R3B),
(ZA,R1J,R2H,R3C),(ZA,R1J,R2H,R3D),(ZA,R1J,R2H,R3E),
(ZA,R1J,R2H,R3F),(ZA,R1J,R2H,R3G),(ZA,R1J,R2H,R3H),
(ZA,R1J,R2H,R3I),(ZA,R1J,R2H,R3J),(ZA,R1J,R2H,R3K),
(ZA,R1J,R2H,R3L),(ZA,R1J,R2H,R3M),(ZA,R1J,R2H,R3N),
(ZA,R1J,R2H,R3O),(ZA,R1J,R2H,R3P),(ZA,R1J,R2H,R3Q),
(ZA,R1J,R2H,R3R),(ZA,R1J,R2I,R3A),(ZA,R1J,R2I,R3B),
(ZA,R1J,R2I,R3C),(ZA,R1J,R2I,R3D),(ZA,R1J,R2I,R3E),
(ZA,R1J,R2I,R3F),(ZA,R1J,R2I,R3G),(ZA,R1J,R2I,R3H),
(ZA,R1J,R2I,R3I),(ZA,R1J,R2I,R3J),(ZA,R1J,R2I,R3K),
(ZA,R1J,R2I,R3L),(ZA,R1J,R2I,R3M),(ZA,R1J,R2I,R3N),
(ZA,R1J,R2I,R3O),(ZA,R1J,R2I,R3P),(ZA,R1J,R2I,R3Q),
(ZA,R1J,R2I,R3R),(ZA,R1J,R2J,R3A),(ZA,R1J,R2J,R3B),
(ZA,R1J,R2J,R3C),(ZA,R1J,R2J,R3D),(ZA,R1J,R2J,R3E),
(ZA,R1J,R2J,R3F),(ZA,R1J,R2J,R3G),(ZA,R1J,R2J,R3H),
(ZA,R1J,R2J,R3I),(ZA,R1J,R2J,R3J),(ZA,R1J,R2J,R3K),
(ZA,R1J,R2J,R3L),(ZA,R1J,R2J,R3M),(ZA,R1J,R2J,R3N),
(ZA,R1J,R2J,R3O),(ZA,R1J,R2J,R3P),(ZA,R1J,R2J,R3Q),
(ZA,R1J,R2J,R3R),(ZA,R1J,R2K,R3A),(ZA,R1J,R2K,R3B),
(ZA,R1J,R2K,R3C),(ZA,R1J,R2K,R3D),(ZA,R1J,R2K,R3E),
(ZA,R1J,R2K,R3F),(ZA,R1J,R2K,R3G),(ZA,R1J,R2K,R3H),
(ZA,R1J,R2K,R3I),(ZA,R1J,R2K,R3J),(ZA,R1J,R2K,R3K),
(ZA,R1J,R2K,R3L),(ZA,R1J,R2K,R3M),(ZA,R1J,R2K,R3N),
(ZA,R1J,R2K,R3O),(ZA,R1J,R2K,R3P),(ZA,R1J,R2K,R3Q),
(ZA,R1J,R2K,R3R),(ZA,R1J,R2L,R3A),(ZA,R1J,R2L,R3B),
(ZA,R1J,R2L,R3C),(ZA,R1J,R2L,R3D),(ZA,R1J,R2L,R3E),
(ZA,R1J,R2L,R3F),(ZA,R1J,R2L,R3G),(ZA,R1J,R2L,R3H),
(ZA,R1J,R2L,R3I),(ZA,R1J,R2L,R3J),(ZA,R1J,R2L,R3K),
(ZA,R1J,R2L,R3L),(ZA,R1J,R2L,R3M),(ZA,R1J,R2L,R3N),
(ZA,R1J,R2L,R3O),(ZA,R1J,R2L,R3P),(ZA,R1J,R2L,R3Q),
(ZA,R1J,R2L,R3R),(ZA,R1J,R2M,R3A),(ZA,R1J,R2M,R3B),
(ZA,R1J,R2M,R3C),(ZA,R1J,R2M,R3D),(ZA,R1J,R2M,R3E),
(ZA,R1J,R2M,R3F),(ZA,R1J,R2M,R3G),(ZA,R1J,R2M,R3H),
(ZA,R1J,R2M,R3I),(ZA,R1J,R2M,R3J),(ZA,R1J,R2M,R3K),
(ZA,R1J,R2M,R3L),(ZA,R1J,R2M,R3M),(ZA,R1J,R2M,R3N),
(ZA,R1J,R2M,R3O),(ZA,R1J,R2M,R3P),(ZA,R1J,R2M,R3Q),
(ZA,R1J,R2M,R3R),(ZA,R1J,R2N,R3A),(ZA,R1J,R2N,R3B),
(ZA,R1J,R2N,R3C),(ZA,R1J,R2N,R3D),(ZA,R1J,R2N,R3E),
(ZA,R1J,R2N,R3F),(ZA,R1J,R2N,R3G),(ZA,R1J,R2N,R3H),
(ZA,R1J,R2N,R3I),(ZA,R1J,R2N,R3J),(ZA,R1J,R2N,R3K),
(ZA,R1J,R2N,R3L),(ZA,R1J,R2N,R3M),(ZA,R1J,R2N,R3N),
(ZA,R1J,R2N,R3O),(ZA,R1J,R2N,R3P),(ZA,R1J,R2N,R3Q),
(ZA,R1J,R2N,R3R),(ZA,R1K,R2A,R3A),(ZA,R1K,R2A,R3B),
(ZA,R1K,R2A,R3C),(ZA,R1K,R2A,R3D),(ZA,R1K,R2A,R3E),
(ZA,R1K,R2A,R3F),(ZA,R1K,R2A,R3G),(ZA,R1K,R2A,R3H),
(ZA,R1K,R2A,R3I),(ZA,R1K,R2A,R3J),(ZA,R1K,R2A,R3K),
(ZA,R1K,R2A,R3L),(ZA,R1K,R2A,R3M),(ZA,R1K,R2A,R3N),
(ZA,R1K,R2A,R3O),(ZA,R1K,R2A,R3P),(ZA,R1K,R2A,R3Q),
(ZA,R1K,R2A,R3R),(ZA,R1K,R2B,R3A),(ZA,R1K,R2B,R3B),
(ZA,R1K,R2B,R3C),(ZA,R1K,R2B,R3D),(ZA,R1K,R2B,R3E),
(ZA,R1K,R2B,R3F),(ZA,R1K,R2B,R3G),(ZA,R1K,R2B,R3H),
(ZA,R1K,R2B,R3I),(ZA,R1K,R2B,R3J),(ZA,R1K,R2B,R3K),
(ZA,R1K,R2B,R3L),(ZA,R1K,R2B,R3M),(ZA,R1K,R2B,R3N),
(ZA,R1K,R2B,R3O),(ZA,R1K,R2B,R3P),(ZA,R1K,R2B,R3Q),
(ZA,R1K,R2B,R3R),(ZA,R1K,R2C,R3A),(ZA,R1K,R2C,R3B),
(ZA,R1K,R2C,R3C),(ZA,R1K,R2C,R3D),(ZA,R1K,R2C,R3E),
(ZA,R1K,R2C,R3F),(ZA,R1K,R2C,R3G),(ZA,R1K,R2C,R3H),
(ZA,R1K,R2C,R3I),(ZA,R1K,R2C,R3J),(ZA,R1K,R2C,R3K),
(ZA,R1K,R2C,R3L),(ZA,R1K,R2C,R3M),(ZA,R1K,R2C,R3N),
(ZA,R1K,R2C,R3O),(ZA,R1K,R2C,R3P),(ZA,R1K,R2C,R3Q),
(ZA,R1K,R2C,R3R),(ZA,R1K,R2D,R3A),(ZA,R1K,R2D,R3B),
(ZA,R1K,R2D,R3C),(ZA,R1K,R2D,R3D),(ZA,R1K,R2D,R3E),
(ZA,R1K,R2D,R3F),(ZA,R1K,R2D,R3G),(ZA,R1K,R2D,R3H),
(ZA,R1K,R2D,R3I),(ZA,R1K,R2D,R3J),(ZA,R1K,R2D,R3K),
(ZA,R1K,R2D,R3L),(ZA,R1K,R2D,R3M),(ZA,R1K,R2D,R3N),
(ZA,R1K,R2D,R3O),(ZA,R1K,R2D,R3P),(ZA,R1K,R2D,R3Q),
(ZA,R1K,R2D,R3R),(ZA,R1K,R2E,R3A),(ZA,R1K,R2E,R3B),
(ZA,R1K,R2E,R3C),(ZA,R1K,R2E,R3D),(ZA,R1K,R2E,R3E),
(ZA,R1K,R2E,R3F),(ZA,R1K,R2E,R3G),(ZA,R1K,R2E,R3H),
(ZA,R1K,R2E,R3I),(ZA,R1K,R2E,R3J),(ZA,R1K,R2E,R3K),
(ZA,R1K,R2E,R3L),(ZA,R1K,R2E,R3M),(ZA,R1K,R2E,R3N),
(ZA,R1K,R2E,R3O),(ZA,R1K,R2E,R3P),(ZA,R1K,R2E,R3Q),
(ZA,R1K,R2E,R3R),(ZA,R1K,R2F,R3A),(ZA,R1K,R2F,R3B),
(ZA,R1K,R2F,R3C),(ZA,R1K,R2F,R3D),(ZA,R1K,R2F,R3E),
(ZA,R1K,R2F,R3F),(ZA,R1K,R2F,R3G),(ZA,R1K,R2F,R3H),
(ZA,R1K,R2F,R3I),(ZA,R1K,R2F,R3J),(ZA,R1K,R2F,R3K),
(ZA,R1K,R2F,R3L),(ZA,R1K,R2F,R3M),(ZA,R1K,R2F,R3N),
(ZA,R1K,R2F,R3O),(ZA,R1K,R2F,R3P),(ZA,R1K,R2F,R3Q),
(ZA,R1K,R2F,R3R),(ZA,R1K,R2G,R3A),(ZA,R1K,R2G,R3B),
(ZA,R1K,R2G,R3C),(ZA,R1K,R2G,R3D),(ZA,R1K,R2G,R3E),
(ZA,R1K,R2G,R3F),(ZA,R1K,R2G,R3G),(ZA,R1K,R2G,R3H),
(ZA,R1K,R2G,R3I),(ZA,R1K,R2G,R3J),(ZA,R1K,R2G,R3K),
(ZA,R1K,R2G,R3L),(ZA,R1K,R2G,R3M),(ZA,R1K,R2G,R3N),
(ZA,R1K,R2G,R3O),(ZA,R1K,R2G,R3P),(ZA,R1K,R2G,R3Q),
(ZA,R1K,R2G,R3R),(ZA,R1K,R2H,R3A),(ZA,R1K,R2H,R3B),
(ZA,R1K,R2H,R3C),(ZA,R1K,R2H,R3D),(ZA,R1K,R2H,R3E),
(ZA,R1K,R2H,R3F),(ZA,R1K,R2H,R3G),(ZA,R1K,R2H,R3H),
(ZA,R1K,R2H,R3I),(ZA,R1K,R2H,R3J),(ZA,R1K,R2H,R3K),
(ZA,R1K,R2H,R3L),(ZA,R1K,R2H,R3M),(ZA,R1K,R2H,R3N),
(ZA,R1K,R2H,R3O),(ZA,R1K,R2H,R3P),(ZA,R1K,R2H,R3Q),
(ZA,R1K,R2H,R3R),(ZA,R1K,R2I,R3A),(ZA,R1K,R2I,R3B),
(ZA,R1K,R2I,R3C),(ZA,R1K,R2I,R3D),(ZA,R1K,R2I,R3E),
(ZA,R1K,R2I,R3F),(ZA,R1K,R2I,R3G),(ZA,R1K,R2I,R3H),
(ZA,R1K,R2I,R3I),(ZA,R1K,R2I,R3J),(ZA,R1K,R2I,R3K),
(ZA,R1K,R2I,R3L),(ZA,R1K,R2I,R3M),(ZA,R1K,R2I,R3N),
(ZA,R1K,R2I,R3O),(ZA,R1K,R2I,R3P),(ZA,R1K,R2I,R3Q),
(ZA,R1K,R2I,R3R),(ZA,R1K,R2J,R3A),(ZA,R1K,R2J,R3B),
(ZA,R1K,R2J,R3C),(ZA,R1K,R2J,R3D),(ZA,R1K,R2J,R3E),
(ZA,R1K,R2J,R3F),(ZA,R1K,R2J,R3G),(ZA,R1K,R2J,R3H),
(ZA,R1K,R2J,R3I),(ZA,R1K,R2J,R3J),(ZA,R1K,R2J,R3K),
(ZA,R1K,R2J,R3L),(ZA,R1K,R2J,R3M),(ZA,R1K,R2J,R3N),
(ZA,R1K,R2J,R3O),(ZA,R1K,R2J,R3P),(ZA,R1K,R2J,R3Q),
(ZA,R1K,R2J,R3R),(ZA,R1K,R2K,R3A),(ZA,R1K,R2K,R3B),
(ZA,R1K,R2K,R3C),(ZA,R1K,R2K,R3D),(ZA,R1K,R2K,R3E),
(ZA,R1K,R2K,R3F),(ZA,R1K,R2K,R3G),(ZA,R1K,R2K,R3H),
(ZA,R1K,R2K,R3I),(ZA,R1K,R2K,R3J),(ZA,R1K,R2K,R3K),
(ZA,R1K,R2K,R3L),(ZA,R1K,R2K,R3M),(ZA,R1K,R2K,R3N),
(ZA,R1K,R2K,R3O),(ZA,R1K,R2K,R3P),(ZA,R1K,R2K,R3Q),
(ZA,R1K,R2K,R3R),(ZA,R1K,R2L,R3A),(ZA,R1K,R2L,R3B),
(ZA,R1K,R2L,R3C),(ZA,R1K,R2L,R3D),(ZA,R1K,R2L,R3E),
(ZA,R1K,R2L,R3F),(ZA,R1K,R2L,R3G),(ZA,R1K,R2L,R3H),
(ZA,R1K,R2L,R3I),(ZA,R1K,R2L,R3J),(ZA,R1K,R2L,R3K),
(ZA,R1K,R2L,R3L),(ZA,R1K,R2L,R3M),(ZA,R1K,R2L,R3N),
(ZA,R1K,R2L,R3O),(ZA,R1K,R2L,R3P),(ZA,R1K,R2L,R3Q),
(ZA,R1K,R2L,R3R),(ZA,R1K,R2M,R3A),(ZA,R1K,R2M,R3B),
(ZA,R1K,R2M,R3C),(ZA,R1K,R2M,R3D),(ZA,R1K,R2M,R3E),
(ZA,R1K,R2M,R3F),(ZA,R1K,R2M,R3G),(ZA,R1K,R2M,R3H),
(ZA,R1K,R2M,R3I),(ZA,R1K,R2M,R3J),(ZA,R1K,R2M,R3K),
(ZA,R1K,R2M,R3L),(ZA,R1K,R2M,R3M),(ZA,R1K,R2M,R3N),
(ZA,R1K,R2M,R3O),(ZA,R1K,R2M,R3P),(ZA,R1K,R2M,R3Q),
(ZA,R1K,R2M,R3R),(ZA,R1K,R2N,R3A),(ZA,R1K,R2N,R3B),
(ZA,R1K,R2N,R3C),(ZA,R1K,R2N,R3D),(ZA,R1K,R2N,R3E),
(ZA,R1K,R2N,R3F),(ZA,R1K,R2N,R3G),(ZA,R1K,R2N,R3H),
(ZA,R1K,R2N,R3I),(ZA,R1K,R2N,R3J),(ZA,R1K,R2N,R3K),
(ZA,R1K,R2N,R3L),(ZA,R1K,R2N,R3M),(ZA,R1K,R2N,R3N),
(ZA,R1K,R2N,R3O),(ZA,R1K,R2N,R3P),(ZA,R1K,R2N,R3Q),
(ZA,R1K,R2N,R3R),(ZA,R1L,R2A,R3A),(ZA,R1L,R2A,R3B),
(ZA,R1L,R2A,R3C),(ZA,R1L,R2A,R3D),(ZA,R1L,R2A,R3E),
(ZA,R1L,R2A,R3F),(ZA,R1L,R2A,R3G),(ZA,R1L,R2A,R3H),
(ZA,R1L,R2A,R3I),(ZA,R1L,R2A,R3J),(ZA,R1L,R2A,R3K),
(ZA,R1L,R2A,R3L),(ZA,R1L,R2A,R3M),(ZA,R1L,R2A,R3N),
(ZA,R1L,R2A,R3O),(ZA,R1L,R2A,R3P),(ZA,R1L,R2A,R3Q),
(ZA,R1L,R2A,R3R),(ZA,R1L,R2B,R3A),(ZA,R1L,R2B,R3B),
(ZA,R1L,R2B,R3C),(ZA,R1L,R2B,R3D),(ZA,R1L,R2B,R3E),
(ZA,R1L,R2B,R3F),(ZA,R1L,R2B,R3G),(ZA,R1L,R2B,R3H),
(ZA,R1L,R2B,R3I),(ZA,R1L,R2B,R3J),(ZA,R1L,R2B,R3K),
(ZA,R1L,R2B,R3L),(ZA,R1L,R2B,R3M),(ZA,R1L,R2B,R3N),
(ZA,R1L,R2B,R3O),(ZA,R1L,R2B,R3P),(ZA,R1L,R2B,R3Q),
(ZA,R1L,R2B,R3R),(ZA,R1L,R2C,R3A),(ZA,R1L,R2C,R3B),
(ZA,R1L,R2C,R3C),(ZA,R1L,R2C,R3D),(ZA,R1L,R2C,R3E),
(ZA,R1L,R2C,R3F),(ZA,R1L,R2C,R3G),(ZA,R1L,R2C,R3H),
(ZA,R1L,R2C,R3I),(ZA,R1L,R2C,R3J),(ZA,R1L,R2C,R3K),
(ZA,R1L,R2C,R3L),(ZA,R1L,R2C,R3M),(ZA,R1L,R2C,R3N),
(ZA,R1L,R2C,R3O),(ZA,R1L,R2C,R3P),(ZA,R1L,R2C,R3Q),
(ZA,R1L,R2C,R3R),(ZA,R1L,R2D,R3A),(ZA,R1L,R2D,R3B),
(ZA,R1L,R2D,R3C),(ZA,R1L,R2D,R3D),(ZA,R1L,R2D,R3E),
(ZA,R1L,R2D,R3F),(ZA,R1L,R2D,R3G),(ZA,R1L,R2D,R3H),
(ZA,R1L,R2D,R3I),(ZA,R1L,R2D,R3J),(ZA,R1L,R2D,R3K),
(ZA,R1L,R2D,R3L),(ZA,R1L,R2D,R3M),(ZA,R1L,R2D,R3N),
(ZA,R1L,R2D,R3O),(ZA,R1L,R2D,R3P),(ZA,R1L,R2D,R3Q),
(ZA,R1L,R2D,R3R),(ZA,R1L,R2E,R3A),(ZA,R1L,R2E,R3B),
(ZA,R1L,R2E,R3C),(ZA,R1L,R2E,R3D),(ZA,R1L,R2E,R3E),
(ZA,R1L,R2E,R3F),(ZA,R1L,R2E,R3G),(ZA,R1L,R2E,R3H),
(ZA,R1L,R2E,R3I),(ZA,R1L,R2E,R3J),(ZA,R1L,R2E,R3K),
(ZA,R1L,R2E,R3L),(ZA,R1L,R2E,R3M),(ZA,R1L,R2E,R3N),
(ZA,R1L,R2E,R3O),(ZA,R1L,R2E,R3P),(ZA,R1L,R2E,R3Q),
(ZA,R1L,R2E,R3R),(ZA,R1L,R2F,R3A),(ZA,R1L,R2F,R3B),
(ZA,R1L,R2F,R3C),(ZA,R1L,R2F,R3D),(ZA,R1L,R2F,R3E),
(ZA,R1L,R2F,R3F),(ZA,R1L,R2F,R3G),(ZA,R1L,R2F,R3H),
(ZA,R1L,R2F,R3I),(ZA,R1L,R2F,R3J),(ZA,R1L,R2F,R3K),
(ZA,R1L,R2F,R3L),(ZA,R1L,R2F,R3M),(ZA,R1L,R2F,R3N),
(ZA,R1L,R2F,R3O),(ZA,R1L,R2F,R3P),(ZA,R1L,R2F,R3Q),
(ZA,R1L,R2F,R3R),(ZA,R1L,R2G,R3A),(ZA,R1L,R2G,R3B),
(ZA,R1L,R2G,R3C),(ZA,R1L,R2G,R3D),(ZA,R1L,R2G,R3E),
(ZA,R1L,R2G,R3F),(ZA,R1L,R2G,R3G),(ZA,R1L,R2G,R3H),
(ZA,R1L,R2G,R3I),(ZA,R1L,R2G,R3J),(ZA,R1L,R2G,R3K),
(ZA,R1L,R2G,R3L),(ZA,R1L,R2G,R3M),(ZA,R1L,R2G,R3N),
(ZA,R1L,R2G,R3O),(ZA,R1L,R2G,R3P),(ZA,R1L,R2G,R3Q),
(ZA,R1L,R2G,R3R),(ZA,R1L,R2H,R3A),(ZA,R1L,R2H,R3B),
(ZA,R1L,R2H,R3C),(ZA,R1L,R2H,R3D),(ZA,R1L,R2H,R3E),
(ZA,R1L,R2H,R3F),(ZA,R1L,R2H,R3G),(ZA,R1L,R2H,R3H),
(ZA,R1L,R2H,R3I),(ZA,R1L,R2H,R3J),(ZA,R1L,R2H,R3K),
(ZA,R1L,R2H,R3L),(ZA,R1L,R2H,R3M),(ZA,R1L,R2H,R3N),
(ZA,R1L,R2H,R3O),(ZA,R1L,R2H,R3P),(ZA,R1L,R2H,R3Q),
(ZA,R1L,R2H,R3R),(ZA,R1L,R2I,R3A),(ZA,R1L,R2I,R3B),
(ZA,R1L,R2I,R3C),(ZA,R1L,R2I,R3D),(ZA,R1L,R2I,R3E),
(ZA,R1L,R2I,R3F),(ZA,R1L,R2I,R3G),(ZA,R1L,R2I,R3H),
(ZA,R1L,R2I,R3I),(ZA,R1L,R2I,R3J),(ZA,R1L,R2I,R3K),
(ZA,R1L,R2I,R3L),(ZA,R1L,R2I,R3M),(ZA,R1L,R2I,R3N),
(ZA,R1L,R2I,R3O),(ZA,R1L,R2I,R3P),(ZA,R1L,R2I,R3Q),
(ZA,R1L,R2I,R3R),(ZA,R1L,R2J,R3A),(ZA,R1L,R2J,R3B),
(ZA,R1L,R2J,R3C),(ZA,R1L,R2J,R3D),(ZA,R1L,R2J,R3E),
(ZA,R1L,R2J,R3F),(ZA,R1L,R2J,R3G),(ZA,R1L,R2J,R3H),
(ZA,R1L,R2J,R3I),(ZA,R1L,R2J,R3J),(ZA,R1L,R2J,R3K),
(ZA,R1L,R2J,R3L),(ZA,R1L,R2J,R3M),(ZA,R1L,R2J,R3N),
(ZA,R1L,R2J,R3O),(ZA,R1L,R2J,R3P),(ZA,R1L,R2J,R3Q),
(ZA,R1L,R2J,R3R),(ZA,R1L,R2K,R3A),(ZA,R1L,R2K,R3B),
(ZA,R1L,R2K,R3C),(ZA,R1L,R2K,R3D),(ZA,R1L,R2K,R3E),
(ZA,R1L,R2K,R3F),(ZA,R1L,R2K,R3G),(ZA,R1L,R2K,R3H),
(ZA,R1L,R2K,R3I),(ZA,R1L,R2K,R3J),(ZA,R1L,R2K,R3K),
(ZA,R1L,R2K,R3L),(ZA,R1L,R2K,R3M),(ZA,R1L,R2K,R3N),
(ZA,R1L,R2K,R3O),(ZA,R1L,R2K,R3P),(ZA,R1L,R2K,R3Q),
(ZA,R1L,R2K,R3R),(ZA,R1L,R2L,R3A),(ZA,R1L,R2L,R3B),
(ZA,R1L,R2L,R3C),(ZA,R1L,R2L,R3D),(ZA,R1L,R2L,R3E),
(ZA,R1L,R2L,R3F),(ZA,R1L,R2L,R3G),(ZA,R1L,R2L,R3H),
(ZA,R1L,R2L,R3I),(ZA,R1L,R2L,R3J),(ZA,R1L,R2L,R3K),
(ZA,R1L,R2L,R3L),(ZA,R1L,R2L,R3M),(ZA,R1L,R2L,R3N),
(ZA,R1L,R2L,R3O),(ZA,R1L,R2L,R3P),(ZA,R1L,R2L,R3Q),
(ZA,R1L,R2L,R3R),(ZA,R1L,R2M,R3A),(ZA,R1L,R2M,R3B),
(ZA,R1L,R2M,R3C),(ZA,R1L,R2M,R3D),(ZA,R1L,R2M,R3E),
(ZA,R1L,R2M,R3F),(ZA,R1L,R2M,R3G),(ZA,R1L,R2M,R3H),
(ZA,R1L,R2M,R3I),(ZA,R1L,R2M,R3J),(ZA,R1L,R2M,R3K),
(ZA,R1L,R2M,R3L),(ZA,R1L,R2M,R3M),(ZA,R1L,R2M,R3N),
(ZA,R1L,R2M,R3O),(ZA,R1L,R2M,R3P),(ZA,R1L,R2M,R3Q),
(ZA,R1L,R2M,R3R),(ZA,R1L,R2N,R3A),(ZA,R1L,R2N,R3B),
(ZA,R1L,R2N,R3C),(ZA,R1L,R2N,R3D),(ZA,R1L,R2N,R3E),
(ZA,R1L,R2N,R3F),(ZA,R1L,R2N,R3G),(ZA,R1L,R2N,R3H),
(ZA,R1L,R2N,R3I),(ZA,R1L,R2N,R3J),(ZA,R1L,R2N,R3K),
(ZA,R1L,R2N,R3L),(ZA,R1L,R2N,R3M),(ZA,R1L,R2N,R3N),
(ZA,R1L,R2N,R3O),(ZA,R1L,R2N,R3P),(ZA,R1L,R2N,R3Q),
(ZA,R1L,R2N,R3R),(ZA,R1M,R2A,R3A),(ZA,R1M,R2A,R3B),
(ZA,R1M,R2A,R3C),(ZA,R1M,R2A,R3D),(ZA,R1M,R2A,R3E),
(ZA,R1M,R2A,R3F),(ZA,R1M,R2A,R3G),(ZA,R1M,R2A,R3H),
(ZA,R1M,R2A,R3I),(ZA,R1M,R2A,R3J),(ZA,R1M,R2A,R3K),
(ZA,R1M,R2A,R3L),(ZA,R1M,R2A,R3M),(ZA,R1M,R2A,R3N),
(ZA,R1M,R2A,R3O),(ZA,R1M,R2A,R3P),(ZA,R1M,R2A,R3Q),
(ZA,R1M,R2A,R3R),(ZA,R1M,R2B,R3A),(ZA,R1M,R2B,R3B),
(ZA,R1M,R2B,R3C),(ZA,R1M,R2B,R3D),(ZA,R1M,R2B,R3E),
(ZA,R1M,R2B,R3F),(ZA,R1M,R2B,R3G),(ZA,R1M,R2B,R3H),
(ZA,R1M,R2B,R3I),(ZA,R1M,R2B,R3J),(ZA,R1M,R2B,R3K),
(ZA,R1M,R2B,R3L),(ZA,R1M,R2B,R3M),(ZA,R1M,R2B,R3N),
(ZA,R1M,R2B,R3O),(ZA,R1M,R2B,R3P),(ZA,R1M,R2B,R3Q),
(ZA,R1M,R2B,R3R),(ZA,R1M,R2C,R3A),(ZA,R1M,R2C,R3B),
(ZA,R1M,R2C,R3C),(ZA,R1M,R2C,R3D),(ZA,R1M,R2C,R3E),
(ZA,R1M,R2C,R3F),(ZA,R1M,R2C,R3G),(ZA,R1M,R2C,R3H),
(ZA,R1M,R2C,R3I),(ZA,R1M,R2C,R3J),(ZA,R1M,R2C,R3K),
(ZA,R1M,R2C,R3L),(ZA,R1M,R2C,R3M),(ZA,R1M,R2C,R3N),
(ZA,R1M,R2C,R3O),(ZA,R1M,R2C,R3P),(ZA,R1M,R2C,R3Q),
(ZA,R1M,R2C,R3R),(ZA,R1M,R2D,R3A),(ZA,R1M,R2D,R3B),
(ZA,R1M,R2D,R3C),(ZA,R1M,R2D,R3D),(ZA,R1M,R2D,R3E),
(ZA,R1M,R2D,R3F),(ZA,R1M,R2D,R3G),(ZA,R1M,R2D,R3H),
(ZA,R1M,R2D,R3I),(ZA,R1M,R2D,R3J),(ZA,R1M,R2D,R3K),
(ZA,R1M,R2D,R3L),(ZA,R1M,R2D,R3M),(ZA,R1M,R2D,R3N),
(ZA,R1M,R2D,R3O),(ZA,R1M,R2D,R3P),(ZA,R1M,R2D,R3Q),
(ZA,R1M,R2D,R3R),(ZA,R1M,R2E,R3A),(ZA,R1M,R2E,R3B),
(ZA,R1M,R2E,R3C),(ZA,R1M,R2E,R3D),(ZA,R1M,R2E,R3E),
(ZA,R1M,R2E,R3F),(ZA,R1M,R2E,R3G),(ZA,R1M,R2E,R3H),
(ZA,R1M,R2E,R3I),(ZA,R1M,R2E,R3J),(ZA,R1M,R2E,R3K),
(ZA,R1M,R2E,R3L),(ZA,R1M,R2E,R3M),(ZA,R1M,R2E,R3N),
(ZA,R1M,R2E,R3O),(ZA,R1M,R2E,R3P),(ZA,R1M,R2E,R3Q),
(ZA,R1M,R2E,R3R),(ZA,R1M,R2F,R3A),(ZA,R1M,R2F,R3B),
(ZA,R1M,R2F,R3C),(ZA,R1M,R2F,R3D),(ZA,R1M,R2F,R3E),
(ZA,R1M,R2F,R3F),(ZA,R1M,R2F,R3G),(ZA,R1M,R2F,R3H),
(ZA,R1M,R2F,R3I),(ZA,R1M,R2F,R3J),(ZA,R1M,R2F,R3K),
(ZA,R1M,R2F,R3L),(ZA,R1M,R2F,R3M),(ZA,R1M,R2F,R3N),
(ZA,R1M,R2F,R3O),(ZA,R1M,R2F,R3P),(ZA,R1M,R2F,R3Q),
(ZA,R1M,R2F,R3R),(ZA,R1M,R2G,R3A),(ZA,R1M,R2G,R3B),
(ZA,R1M,R2G,R3C),(ZA,R1M,R2G,R3D),(ZA,R1M,R2G,R3E),
(ZA,R1M,R2G,R3F),(ZA,R1M,R2G,R3G),(ZA,R1M,R2G,R3H),
(ZA,R1M,R2G,R3I),(ZA,R1M,R2G,R3J),(ZA,R1M,R2G,R3K),
(ZA,R1M,R2G,R3L),(ZA,R1M,R2G,R3M),(ZA,R1M,R2G,R3N),
(ZA,R1M,R2G,R3O),(ZA,R1M,R2G,R3P),(ZA,R1M,R2G,R3Q),
(ZA,R1M,R2G,R3R),(ZA,R1M,R2H,R3A),(ZA,R1M,R2H,R3B),
(ZA,R1M,R2H,R3C),(ZA,R1M,R2H,R3D),(ZA,R1M,R2H,R3E),
(ZA,R1M,R2H,R3F),(ZA,R1M,R2H,R3G),(ZA,R1M,R2H,R3H),
(ZA,R1M,R2H,R3I),(ZA,R1M,R2H,R3J),(ZA,R1M,R2H,R3K),
(ZA,R1M,R2H,R3L),(ZA,R1M,R2H,R3M),(ZA,R1M,R2H,R3N),
(ZA,R1M,R2H,R3O),(ZA,R1M,R2H,R3P),(ZA,R1M,R2H,R3Q),
(ZA,R1M,R2H,R3R),(ZA,R1M,R2I,R3A),(ZA,R1M,R2I,R3B),
(ZA,R1M,R2I,R3C),(ZA,R1M,R2I,R3D),(ZA,R1M,R2I,R3E),
(ZA,R1M,R2I,R3F),(ZA,R1M,R2I,R3G),(ZA,R1M,R2I,R3H),
(ZA,R1M,R2I,R3I),(ZA,R1M,R2I,R3J),(ZA,R1M,R2I,R3K),
(ZA,R1M,R2I,R3L),(ZA,R1M,R2I,R3M),(ZA,R1M,R2I,R3N),
(ZA,R1M,R2I,R3O),(ZA,R1M,R2I,R3P),(ZA,R1M,R2I,R3Q),
(ZA,R1M,R2I,R3R),(ZA,R1M,R2J,R3A),(ZA,R1M,R2J,R3B),
(ZA,R1M,R2J,R3C),(ZA,R1M,R2J,R3D),(ZA,R1M,R2J,R3E),
(ZA,R1M,R2J,R3F),(ZA,R1M,R2J,R3G),(ZA,R1M,R2J,R3H),
(ZA,R1M,R2J,R3I),(ZA,R1M,R2J,R3J),(ZA,R1M,R2J,R3K),
(ZA,R1M,R2J,R3L),(ZA,R1M,R2J,R3M),(ZA,R1M,R2J,R3N),
(ZA,R1M,R2J,R3O),(ZA,R1M,R2J,R3P),(ZA,R1M,R2J,R3Q),
(ZA,R1M,R2J,R3R),(ZA,R1M,R2K,R3A),(ZA,R1M,R2K,R3B),
(ZA,R1M,R2K,R3C),(ZA,R1M,R2K,R3D),(ZA,R1M,R2K,R3E),
(ZA,R1M,R2K,R3F),(ZA,R1M,R2K,R3G),(ZA,R1M,R2K,R3H),
(ZA,R1M,R2K,R3I),(ZA,R1M,R2K,R3J),(ZA,R1M,R2K,R3K),
(ZA,R1M,R2K,R3L),(ZA,R1M,R2K,R3M),(ZA,R1M,R2K,R3N),
(ZA,R1M,R2K,R3O),(ZA,R1M,R2K,R3P),(ZA,R1M,R2K,R3Q),
(ZA,R1M,R2K,R3R),(ZA,R1M,R2L,R3A),(ZA,R1M,R2L,R3B),
(ZA,R1M,R2L,R3C),(ZA,R1M,R2L,R3D),(ZA,R1M,R2L,R3E),
(ZA,R1M,R2L,R3F),(ZA,R1M,R2L,R3G),(ZA,R1M,R2L,R3H),
(ZA,R1M,R2L,R3I),(ZA,R1M,R2L,R3J),(ZA,R1M,R2L,R3K),
(ZA,R1M,R2L,R3L),(ZA,R1M,R2L,R3M),(ZA,R1M,R2L,R3N),
(ZA,R1M,R2L,R3O),(ZA,R1M,R2L,R3P),(ZA,R1M,R2L,R3Q),
(ZA,R1M,R2L,R3R),(ZA,R1M,R2M,R3A),(ZA,R1M,R2M,R3B),
(ZA,R1M,R2M,R3C),(ZA,R1M,R2M,R3D),(ZA,R1M,R2M,R3E),
(ZA,R1M,R2M,R3F),(ZA,R1M,R2M,R3G),(ZA,R1M,R2M,R3H),
(ZA,R1M,R2M,R3I),(ZA,R1M,R2M,R3J),(ZA,R1M,R2M,R3K),
(ZA,R1M,R2M,R3L),(ZA,R1M,R2M,R3M),(ZA,R1M,R2M,R3N),
(ZA,R1M,R2M,R3O),(ZA,R1M,R2M,R3P),(ZA,R1M,R2M,R3Q),
(ZA,R1M,R2M,R3R),(ZA,R1M,R2N,R3A),(ZA,R1M,R2N,R3B),
(ZA,R1M,R2N,R3C),(ZA,R1M,R2N,R3D),(ZA,R1M,R2N,R3E),
(ZA,R1M,R2N,R3F),(ZA,R1M,R2N,R3G),(ZA,R1M,R2N,R3H),
(ZA,R1M,R2N,R3I),(ZA,R1M,R2N,R3J),(ZA,R1M,R2N,R3K),
(ZA,R1M,R2N,R3L),(ZA,R1M,R2N,R3M),(ZA,R1M,R2N,R3N),
(ZA,R1M,R2N,R3O),(ZA,R1M,R2N,R3P),(ZA,R1M,R2N,R3Q),
(ZA,R1M,R2N,R3R),(ZA,R1N,R2A,R3A),(ZA,R1N,R2A,R3B),
(ZA,R1N,R2A,R3C),(ZA,R1N,R2A,R3D),(ZA,R1N,R2A,R3E),
(ZA,R1N,R2A,R3F),(ZA,R1N,R2A,R3G),(ZA,R1N,R2A,R3H),
(ZA,R1N,R2A,R3I),(ZA,R1N,R2A,R3J),(ZA,R1N,R2A,R3K),
(ZA,R1N,R2A,R3L),(ZA,R1N,R2A,R3M),(ZA,R1N,R2A,R3N),
(ZA,R1N,R2A,R3O),(ZA,R1N,R2A,R3P),(ZA,R1N,R2A,R3Q),
(ZA,R1N,R2A,R3R),(ZA,R1N,R2B,R3A),(ZA,R1N,R2B,R3B),
(ZA,R1N,R2B,R3C),(ZA,R1N,R2B,R3D),(ZA,R1N,R2B,R3E),
(ZA,R1N,R2B,R3F),(ZA,R1N,R2B,R3G),(ZA,R1N,R2B,R3H),
(ZA,R1N,R2B,R3I),(ZA,R1N,R2B,R3J),(ZA,R1N,R2B,R3K),
(ZA,R1N,R2B,R3L),(ZA,R1N,R2B,R3M),(ZA,R1N,R2B,R3N),
(ZA,R1N,R2B,R3O),(ZA,R1N,R2B,R3P),(ZA,R1N,R2B,R3Q),
(ZA,R1N,R2B,R3R),(ZA,R1N,R2C,R3A),(ZA,R1N,R2C,R3B),
(ZA,R1N,R2C,R3C),(ZA,R1N,R2C,R3D),(ZA,R1N,R2C,R3E),
(ZA,R1N,R2C,R3F),(ZA,R1N,R2C,R3G),(ZA,R1N,R2C,R3H),
(ZA,R1N,R2C,R3I),(ZA,R1N,R2C,R3J),(ZA,R1N,R2C,R3K),
(ZA,R1N,R2C,R3L),(ZA,R1N,R2C,R3M),(ZA,R1N,R2C,R3N),
(ZA,R1N,R2C,R3O),(ZA,R1N,R2C,R3P),(ZA,R1N,R2C,R3Q),
(ZA,R1N,R2C,R3R),(ZA,R1N,R2D,R3A),(ZA,R1N,R2D,R3B),
(ZA,R1N,R2D,R3C),(ZA,R1N,R2D,R3D),(ZA,R1N,R2D,R3E),
(ZA,R1N,R2D,R3F),(ZA,R1N,R2D,R3G),(ZA,R1N,R2D,R3H),
(ZA,R1N,R2D,R3I),(ZA,R1N,R2D,R3J),(ZA,R1N,R2D,R3K),
(ZA,R1N,R2D,R3L),(ZA,R1N,R2D,R3M),(ZA,R1N,R2D,R3N),
(ZA,R1N,R2D,R3O),(ZA,R1N,R2D,R3P),(ZA,R1N,R2D,R3Q),
(ZA,R1N,R2D,R3R),(ZA,R1N,R2E,R3A),(ZA,R1N,R2E,R3B),
(ZA,R1N,R2E,R3C),(ZA,R1N,R2E,R3D),(ZA,R1N,R2E,R3E),
(ZA,R1N,R2E,R3F),(ZA,R1N,R2E,R3G),(ZA,R1N,R2E,R3H),
(ZA,R1N,R2E,R3I),(ZA,R1N,R2E,R3J),(ZA,R1N,R2E,R3K),
(ZA,R1N,R2E,R3L),(ZA,R1N,R2E,R3M),(ZA,R1N,R2E,R3N),
(ZA,R1N,R2E,R3O),(ZA,R1N,R2E,R3P),(ZA,R1N,R2E,R3Q),
(ZA,R1N,R2E,R3R),(ZA,R1N,R2F,R3A),(ZA,R1N,R2F,R3B),
(ZA,R1N,R2F,R3C),(ZA,R1N,R2F,R3D),(ZA,R1N,R2F,R3E),
(ZA,R1N,R2F,R3F),(ZA,R1N,R2F,R3G),(ZA,R1N,R2F,R3H),
(ZA,R1N,R2F,R3I),(ZA,R1N,R2F,R3J),(ZA,R1N,R2F,R3K),
(ZA,R1N,R2F,R3L),(ZA,R1N,R2F,R3M),(ZA,R1N,R2F,R3N),
(ZA,R1N,R2F,R3O),(ZA,R1N,R2F,R3P),(ZA,R1N,R2F,R3Q),
(ZA,R1N,R2F,R3R),(ZA,R1N,R2G,R3A),(ZA,R1N,R2G,R3B),
(ZA,R1N,R2G,R3C),(ZA,R1N,R2G,R3D),(ZA,R1N,R2G,R3E),
(ZA,R1N,R2G,R3F),(ZA,R1N,R2G,R3G),(ZA,R1N,R2G,R3H),
(ZA,R1N,R2G,R3I),(ZA,R1N,R2G,R3J),(ZA,R1N,R2G,R3K),
(ZA,R1N,R2G,R3L),(ZA,R1N,R2G,R3M),(ZA,R1N,R2G,R3N),
(ZA,R1N,R2G,R3O),(ZA,R1N,R2G,R3P),(ZA,R1N,R2G,R3Q),
(ZA,R1N,R2G,R3R),(ZA,R1N,R2H,R3A),(ZA,R1N,R2H,R3B),
(ZA,R1N,R2H,R3C),(ZA,R1N,R2H,R3D),(ZA,R1N,R2H,R3E),
(ZA,R1N,R2H,R3F),(ZA,R1N,R2H,R3G),(ZA,R1N,R2H,R3H),
(ZA,R1N,R2H,R3I),(ZA,R1N,R2H,R3J),(ZA,R1N,R2H,R3K),
(ZA,R1N,R2H,R3L),(ZA,R1N,R2H,R3M),(ZA,R1N,R2H,R3N),
(ZA,R1N,R2H,R3O),(ZA,R1N,R2H,R3P),(ZA,R1N,R2H,R3Q),
(ZA,R1N,R2H,R3R),(ZA,R1N,R2I,R3A),(ZA,R1N,R2I,R3B),
(ZA,R1N,R2I,R3C),(ZA,R1N,R2I,R3D),(ZA,R1N,R2I,R3E),
(ZA,R1N,R2I,R3F),(ZA,R1N,R2I,R3G),(ZA,R1N,R2I,R3H),
(ZA,R1N,R2I,R3I),(ZA,R1N,R2I,R3J),(ZA,R1N,R2I,R3K),
(ZA,R1N,R2I,R3L),(ZA,R1N,R2I,R3M),(ZA,R1N,R2I,R3N),
(ZA,R1N,R2I,R3O),(ZA,R1N,R2I,R3P),(ZA,R1N,R2I,R3Q),
(ZA,R1N,R2I,R3R),(ZA,R1N,R2J,R3A),(ZA,R1N,R2J,R3B),
(ZA,R1N,R2J,R3C),(ZA,R1N,R2J,R3D),(ZA,R1N,R2J,R3E),
(ZA,R1N,R2J,R3F),(ZA,R1N,R2J,R3G),(ZA,R1N,R2J,R3H),
(ZA,R1N,R2J,R3I),(ZA,R1N,R2J,R3J),(ZA,R1N,R2J,R3K),
(ZA,R1N,R2J,R3L),(ZA,R1N,R2J,R3M),(ZA,R1N,R2J,R3N),
(ZA,R1N,R2J,R3O),(ZA,R1N,R2J,R3P),(ZA,R1N,R2J,R3Q),
(ZA,R1N,R2J,R3R),(ZA,R1N,R2K,R3A),(ZA,R1N,R2K,R3B),
(ZA,R1N,R2K,R3C),(ZA,R1N,R2K,R3D),(ZA,R1N,R2K,R3E),
(ZA,R1N,R2K,R3F),(ZA,R1N,R2K,R3G),(ZA,R1N,R2K,R3H),
(ZA,R1N,R2K,R3I),(ZA,R1N,R2K,R3J),(ZA,R1N,R2K,R3K),
(ZA,R1N,R2K,R3L),(ZA,R1N,R2K,R3M),(ZA,R1N,R2K,R3N),
(ZA,R1N,R2K,R3O),(ZA,R1N,R2K,R3P),(ZA,R1N,R2K,R3Q),
(ZA,R1N,R2K,R3R),(ZA,R1N,R2L,R3A),(ZA,R1N,R2L,R3B),
(ZA,R1N,R2L,R3C),(ZA,R1N,R2L,R3D),(ZA,R1N,R2L,R3E),
(ZA,R1N,R2L,R3F),(ZA,R1N,R2L,R3G),(ZA,R1N,R2L,R3H),
(ZA,R1N,R2L,R3I),(ZA,R1N,R2L,R3J),(ZA,R1N,R2L,R3K),
(ZA,R1N,R2L,R3L),(ZA,R1N,R2L,R3M),(ZA,R1N,R2L,R3N),
(ZA,R1N,R2L,R3O),(ZA,R1N,R2L,R3P),(ZA,R1N,R2L,R3Q),
(ZA,R1N,R2L,R3R),(ZA,R1N,R2M,R3A),(ZA,R1N,R2M,R3B),
(ZA,R1N,R2M,R3C),(ZA,R1N,R2M,R3D),(ZA,R1N,R2M,R3E),
(ZA,R1N,R2M,R3F),(ZA,R1N,R2M,R3G),(ZA,R1N,R2M,R3H),
(ZA,R1N,R2M,R3I),(ZA,R1N,R2M,R3J),(ZA,R1N,R2M,R3K),
(ZA,R1N,R2M,R3L),(ZA,R1N,R2M,R3M),(ZA,R1N,R2M,R3N),
(ZA,R1N,R2M,R3O),(ZA,R1N,R2M,R3P),(ZA,R1N,R2M,R3Q),
(ZA,R1N,R2M,R3R),(ZA,R1N,R2N,R3A),(ZA,R1N,R2N,R3B),
(ZA,R1N,R2N,R3C),(ZA,R1N,R2N,R3D),(ZA,R1N,R2N,R3E),
(ZA,R1N,R2N,R3F),(ZA,R1N,R2N,R3G),(ZA,R1N,R2N,R3H),
(ZA,R1N,R2N,R3I),(ZA,R1N,R2N,R3J),(ZA,R1N,R2N,R3K),
(ZA,R1N,R2N,R3L),(ZA,R1N,R2N,R3M),(ZA,R1N,R2N,R3N),
(ZA,R1N,R2N,R3O),(ZA,R1N,R2N,R3P),(ZA,R1N,R2N,R3Q),
(ZA,R1N,R2N,R3R),(ZA,R1O,R2A,R3A),(ZA,R1O,R2A,R3B),
(ZA,R1O,R2A,R3C),(ZA,R1O,R2A,R3D),(ZA,R1O,R2A,R3E),
(ZA,R1O,R2A,R3F),(ZA,R1O,R2A,R3G),(ZA,R1O,R2A,R3H),
(ZA,R1O,R2A,R3I),(ZA,R1O,R2A,R3J),(ZA,R1O,R2A,R3K),
(ZA,R1O,R2A,R3L),(ZA,R1O,R2A,R3M),(ZA,R1O,R2A,R3N),
(ZA,R1O,R2A,R3O),(ZA,R1O,R2A,R3P),(ZA,R1O,R2A,R3Q),
(ZA,R1O,R2A,R3R),(ZA,R1O,R2B,R3A),(ZA,R1O,R2B,R3B),
(ZA,R1O,R2B,R3C),(ZA,R1O,R2B,R3D),(ZA,R1O,R2B,R3E),
(ZA,R1O,R2B,R3F),(ZA,R1O,R2B,R3G),(ZA,R1O,R2B,R3H),
(ZA,R1O,R2B,R3I),(ZA,R1O,R2B,R3J),(ZA,R1O,R2B,R3K),
(ZA,R1O,R2B,R3L),(ZA,R1O,R2B,R3M),(ZA,R1O,R2B,R3N),
(ZA,R1O,R2B,R3O),(ZA,R1O,R2B,R3P),(ZA,R1O,R2B,R3Q),
(ZA,R1O,R2B,R3R),(ZA,R1O,R2C,R3A),(ZA,R1O,R2C,R3B),
(ZA,R1O,R2C,R3C),(ZA,R1O,R2C,R3D),(ZA,R1O,R2C,R3E),
(ZA,R1O,R2C,R3F),(ZA,R1O,R2C,R3G),(ZA,R1O,R2C,R3H),
(ZA,R1O,R2C,R3I),(ZA,R1O,R2C,R3J),(ZA,R1O,R2C,R3K),
(ZA,R1O,R2C,R3L),(ZA,R1O,R2C,R3M),(ZA,R1O,R2C,R3N),
(ZA,R1O,R2C,R3O),(ZA,R1O,R2C,R3P),(ZA,R1O,R2C,R3Q),
(ZA,R1O,R2C,R3R),(ZA,R1O,R2D,R3A),(ZA,R1O,R2D,R3B),
(ZA,R1O,R2D,R3C),(ZA,R1O,R2D,R3D),(ZA,R1O,R2D,R3E),
(ZA,R1O,R2D,R3F),(ZA,R1O,R2D,R3G),(ZA,R1O,R2D,R3H),
(ZA,R1O,R2D,R3I),(ZA,R1O,R2D,R3J),(ZA,R1O,R2D,R3K),
(ZA,R1O,R2D,R3L),(ZA,R1O,R2D,R3M),(ZA,R1O,R2D,R3N),
(ZA,R1O,R2D,R3O),(ZA,R1O,R2D,R3P),(ZA,R1O,R2D,R3Q),
(ZA,R1O,R2D,R3R),(ZA,R1O,R2E,R3A),(ZA,R1O,R2E,R3B),
(ZA,R1O,R2E,R3C),(ZA,R1O,R2E,R3D),(ZA,R1O,R2E,R3E),
(ZA,R1O,R2E,R3F),(ZA,R1O,R2E,R3G),(ZA,R1O,R2E,R3H),
(ZA,R1O,R2E,R3I),(ZA,R1O,R2E,R3J),(ZA,R1O,R2E,R3K),
(ZA,R1O,R2E,R3L),(ZA,R1O,R2E,R3M),(ZA,R1O,R2E,R3N),
(ZA,R1O,R2E,R3O),(ZA,R1O,R2E,R3P),(ZA,R1O,R2E,R3Q),
(ZA,R1O,R2E,R3R),(ZA,R1O,R2F,R3A),(ZA,R1O,R2F,R3B),
(ZA,R1O,R2F,R3C),(ZA,R1O,R2F,R3D),(ZA,R1O,R2F,R3E),
(ZA,R1O,R2F,R3F),(ZA,R1O,R2F,R3G),(ZA,R1O,R2F,R3H),
(ZA,R1O,R2F,R3I),(ZA,R1O,R2F,R3J),(ZA,R1O,R2F,R3K),
(ZA,R1O,R2F,R3L),(ZA,R1O,R2F,R3M),(ZA,R1O,R2F,R3N),
(ZA,R1O,R2F,R3O),(ZA,R1O,R2F,R3P),(ZA,R1O,R2F,R3Q),
(ZA,R1O,R2F,R3R),(ZA,R1O,R2G,R3A),(ZA,R1O,R2G,R3B),
(ZA,R1O,R2G,R3C),(ZA,R1O,R2G,R3D),(ZA,R1O,R2G,R3E),
(ZA,R1O,R2G,R3F),(ZA,R1O,R2G,R3G),(ZA,R1O,R2G,R3H),
(ZA,R1O,R2G,R3I),(ZA,R1O,R2G,R3J),(ZA,R1O,R2G,R3K),
(ZA,R1O,R2G,R3L),(ZA,R1O,R2G,R3M),(ZA,R1O,R2G,R3N),
(ZA,R1O,R2G,R3O),(ZA,R1O,R2G,R3P),(ZA,R1O,R2G,R3Q),
(ZA,R1O,R2G,R3R),(ZA,R1O,R2H,R3A),(ZA,R1O,R2H,R3B),
(ZA,R1O,R2H,R3C),(ZA,R1O,R2H,R3D),(ZA,R1O,R2H,R3E),
(ZA,R1O,R2H,R3F),(ZA,R1O,R2H,R3G),(ZA,R1O,R2H,R3H),
(ZA,R1O,R2H,R3I),(ZA,R1O,R2H,R3J),(ZA,R1O,R2H,R3K),
(ZA,R1O,R2H,R3L),(ZA,R1O,R2H,R3M),(ZA,R1O,R2H,R3N),
(ZA,R1O,R2H,R3O),(ZA,R1O,R2H,R3P),(ZA,R1O,R2H,R3Q),
(ZA,R1O,R2H,R3R),(ZA,R1O,R2I,R3A),(ZA,R1O,R2I,R3B),
(ZA,R1O,R2I,R3C),(ZA,R1O,R2I,R3D),(ZA,R1O,R2I,R3E),
(ZA,R1O,R2I,R3F),(ZA,R1O,R2I,R3G),(ZA,R1O,R2I,R3H),
(ZA,R1O,R2I,R3I),(ZA,R1O,R2I,R3J),(ZA,R1O,R2I,R3K),
(ZA,R1O,R2I,R3L),(ZA,R1O,R2I,R3M),(ZA,R1O,R2I,R3N),
(ZA,R1O,R2I,R3O),(ZA,R1O,R2I,R3P),(ZA,R1O,R2I,R3Q),
(ZA,R1O,R2I,R3R),(ZA,R1O,R2J,R3A),(ZA,R1O,R2J,R3B),
(ZA,R1O,R2J,R3C),(ZA,R1O,R2J,R3D),(ZA,R1O,R2J,R3E),
(ZA,R1O,R2J,R3F),(ZA,R1O,R2J,R3G),(ZA,R1O,R2J,R3H),
(ZA,R1O,R2J,R3I),(ZA,R1O,R2J,R3J),(ZA,R1O,R2J,R3K),
(ZA,R1O,R2J,R3L),(ZA,R1O,R2J,R3M),(ZA,R1O,R2J,R3N),
(ZA,R1O,R2J,R3O),(ZA,R1O,R2J,R3P),(ZA,R1O,R2J,R3Q),
(ZA,R1O,R2J,R3R),(ZA,R1O,R2K,R3A),(ZA,R1O,R2K,R3B),
(ZA,R1O,R2K,R3C),(ZA,R1O,R2K,R3D),(ZA,R1O,R2K,R3E),
(ZA,R1O,R2K,R3F),(ZA,R1O,R2K,R3G),(ZA,R1O,R2K,R3H),
(ZA,R1O,R2K,R3I),(ZA,R1O,R2K,R3J),(ZA,R1O,R2K,R3K),
(ZA,R1O,R2K,R3L),(ZA,R1O,R2K,R3M),(ZA,R1O,R2K,R3N),
(ZA,R1O,R2K,R3O),(ZA,R1O,R2K,R3P),(ZA,R1O,R2K,R3Q),
(ZA,R1O,R2K,R3R),(ZA,R1O,R2L,R3A),(ZA,R1O,R2L,R3B),
(ZA,R1O,R2L,R3C),(ZA,R1O,R2L,R3D),(ZA,R1O,R2L,R3E),
(ZA,R1O,R2L,R3F),(ZA,R1O,R2L,R3G),(ZA,R1O,R2L,R3H),
(ZA,R1O,R2L,R3I),(ZA,R1O,R2L,R3J),(ZA,R1O,R2L,R3K),
(ZA,R1O,R2L,R3L),(ZA,R1O,R2L,R3M),(ZA,R1O,R2L,R3N),
(ZA,R1O,R2L,R3O),(ZA,R1O,R2L,R3P),(ZA,R1O,R2L,R3Q),
(ZA,R1O,R2L,R3R),(ZA,R1O,R2M,R3A),(ZA,R1O,R2M,R3B),
(ZA,R1O,R2M,R3C),(ZA,R1O,R2M,R3D),(ZA,R1O,R2M,R3E),
(ZA,R1O,R2M,R3F),(ZA,R1O,R2M,R3G),(ZA,R1O,R2M,R3H),
(ZA,R1O,R2M,R3I),(ZA,R1O,R2M,R3J),(ZA,R1O,R2M,R3K),
(ZA,R1O,R2M,R3L),(ZA,R1O,R2M,R3M),(ZA,R1O,R2M,R3N),
(ZA,R1O,R2M,R3O),(ZA,R1O,R2M,R3P),(ZA,R1O,R2M,R3Q),
(ZA,R1O,R2M,R3R),(ZA,R1O,R2N,R3A),(ZA,R1O,R2N,R3B),
(ZA,R1O,R2N,R3C),(ZA,R1O,R2N,R3D),(ZA,R1O,R2N,R3E),
(ZA,R1O,R2N,R3F),(ZA,R1O,R2N,R3G),(ZA,R1O,R2N,R3H),
(ZA,R1O,R2N,R3I),(ZA,R1O,R2N,R3J),(ZA,R1O,R2N,R3K),
(ZA,R1O,R2N,R3L),(ZA,R1O,R2N,R3M),(ZA,R1O,R2N,R3N),
(ZA,R1O,R2N,R3O),(ZA,R1O,R2N,R3P),(ZA,R1O,R2N,R3Q),
(ZA,R1O,R2N,R3R),(ZA,R1P,R2A,R3A),(ZA,R1P,R2A,R3B),
(ZA,R1P,R2A,R3C),(ZA,R1P,R2A,R3D),(ZA,R1P,R2A,R3E),
(ZA,R1P,R2A,R3F),(ZA,R1P,R2A,R3G),(ZA,R1P,R2A,R3H),
(ZA,R1P,R2A,R3I),(ZA,R1P,R2A,R3J),(ZA,R1P,R2A,R3K),
(ZA,R1P,R2A,R3L),(ZA,R1P,R2A,R3M),(ZA,R1P,R2A,R3N),
(ZA,R1P,R2A,R3O),(ZA,R1P,R2A,R3P),(ZA,R1P,R2A,R3Q),
(ZA,R1P,R2A,R3R),(ZA,R1P,R2B,R3A),(ZA,R1P,R2B,R3B),
(ZA,R1P,R2B,R3C),(ZA,R1P,R2B,R3D),(ZA,R1P,R2B,R3E),
(ZA,R1P,R2B,R3F),(ZA,R1P,R2B,R3G),(ZA,R1P,R2B,R3H),
(ZA,R1P,R2B,R3I),(ZA,R1P,R2B,R3J),(ZA,R1P,R2B,R3K),
(ZA,R1P,R2B,R3L),(ZA,R1P,R2B,R3M),(ZA,R1P,R2B,R3N),
(ZA,R1P,R2B,R3O),(ZA,R1P,R2B,R3P),(ZA,R1P,R2B,R3Q),
(ZA,R1P,R2B,R3R),(ZA,R1P,R2C,R3A),(ZA,R1P,R2C,R3B),
(ZA,R1P,R2C,R3C),(ZA,R1P,R2C,R3D),(ZA,R1P,R2C,R3E),
(ZA,R1P,R2C,R3F),(ZA,R1P,R2C,R3G),(ZA,R1P,R2C,R3H),
(ZA,R1P,R2C,R3I),(ZA,R1P,R2C,R3J),(ZA,R1P,R2C,R3K),
(ZA,R1P,R2C,R3L),(ZA,R1P,R2C,R3M),(ZA,R1P,R2C,R3N),
(ZA,R1P,R2C,R3O),(ZA,R1P,R2C,R3P),(ZA,R1P,R2C,R3Q),
(ZA,R1P,R2C,R3R),(ZA,R1P,R2D,R3A),(ZA,R1P,R2D,R3B),
(ZA,R1P,R2D,R3C),(ZA,R1P,R2D,R3D),(ZA,R1P,R2D,R3E),
(ZA,R1P,R2D,R3F),(ZA,R1P,R2D,R3G),(ZA,R1P,R2D,R3H),
(ZA,R1P,R2D,R3I),(ZA,R1P,R2D,R3J),(ZA,R1P,R2D,R3K),
(ZA,R1P,R2D,R3L),(ZA,R1P,R2D,R3M),(ZA,R1P,R2D,R3N),
(ZA,R1P,R2D,R3O),(ZA,R1P,R2D,R3P),(ZA,R1P,R2D,R3Q),
(ZA,R1P,R2D,R3R),(ZA,R1P,R2E,R3A),(ZA,R1P,R2E,R3B),
(ZA,R1P,R2E,R3C),(ZA,R1P,R2E,R3D),(ZA,R1P,R2E,R3E),
(ZA,R1P,R2E,R3F),(ZA,R1P,R2E,R3G),(ZA,R1P,R2E,R3H),
(ZA,R1P,R2E,R3I),(ZA,R1P,R2E,R3J),(ZA,R1P,R2E,R3K),
(ZA,R1P,R2E,R3L),(ZA,R1P,R2E,R3M),(ZA,R1P,R2E,R3N),
(ZA,R1P,R2E,R3O),(ZA,R1P,R2E,R3P),(ZA,R1P,R2E,R3Q),
(ZA,R1P,R2E,R3R),(ZA,R1P,R2F,R3A),(ZA,R1P,R2F,R3B),
(ZA,R1P,R2F,R3C),(ZA,R1P,R2F,R3D),(ZA,R1P,R2F,R3E),
(ZA,R1P,R2F,R3F),(ZA,R1P,R2F,R3G),(ZA,R1P,R2F,R3H),
(ZA,R1P,R2F,R3I),(ZA,R1P,R2F,R3J),(ZA,R1P,R2F,R3K),
(ZA,R1P,R2F,R3L),(ZA,R1P,R2F,R3M),(ZA,R1P,R2F,R3N),
(ZA,R1P,R2F,R3O),(ZA,R1P,R2F,R3P),(ZA,R1P,R2F,R3Q),
(ZA,R1P,R2F,R3R),(ZA,R1P,R2G,R3A),(ZA,R1P,R2G,R3B),
(ZA,R1P,R2G,R3C),(ZA,R1P,R2G,R3D),(ZA,R1P,R2G,R3E),
(ZA,R1P,R2G,R3F),(ZA,R1P,R2G,R3G),(ZA,R1P,R2G,R3H),
(ZA,R1P,R2G,R3I),(ZA,R1P,R2G,R3J),(ZA,R1P,R2G,R3K),
(ZA,R1P,R2G,R3L),(ZA,R1P,R2G,R3M),(ZA,R1P,R2G,R3N),
(ZA,R1P,R2G,R3O),(ZA,R1P,R2G,R3P),(ZA,R1P,R2G,R3Q),
(ZA,R1P,R2G,R3R),(ZA,R1P,R2H,R3A),(ZA,R1P,R2H,R3B),
(ZA,R1P,R2H,R3C),(ZA,R1P,R2H,R3D),(ZA,R1P,R2H,R3E),
(ZA,R1P,R2H,R3F),(ZA,R1P,R2H,R3G),(ZA,R1P,R2H,R3H),
(ZA,R1P,R2H,R3I),(ZA,R1P,R2H,R3J),(ZA,R1P,R2H,R3K),
(ZA,R1P,R2H,R3L),(ZA,R1P,R2H,R3M),(ZA,R1P,R2H,R3N),
(ZA,R1P,R2H,R3O),(ZA,R1P,R2H,R3P),(ZA,R1P,R2H,R3Q),
(ZA,R1P,R2H,R3R),(ZA,R1P,R2I,R3A),(ZA,R1P,R2I,R3B),
(ZA,R1P,R2I,R3C),(ZA,R1P,R2I,R3D),(ZA,R1P,R2I,R3E),
(ZA,R1P,R2I,R3F),(ZA,R1P,R2I,R3G),(ZA,R1P,R2I,R3H),
(ZA,R1P,R2I,R3I),(ZA,R1P,R2I,R3J),(ZA,R1P,R2I,R3K),
(ZA,R1P,R2I,R3L),(ZA,R1P,R2I,R3M),(ZA,R1P,R2I,R3N),
(ZA,R1P,R2I,R3O),(ZA,R1P,R2I,R3P),(ZA,R1P,R2I,R3Q),
(ZA,R1P,R2I,R3R),(ZA,R1P,R2J,R3A),(ZA,R1P,R2J,R3B),
(ZA,R1P,R2J,R3C),(ZA,R1P,R2J,R3D),(ZA,R1P,R2J,R3E),
(ZA,R1P,R2J,R3F),(ZA,R1P,R2J,R3G),(ZA,R1P,R2J,R3H),
(ZA,R1P,R2J,R3I),(ZA,R1P,R2J,R3J),(ZA,R1P,R2J,R3K),
(ZA,R1P,R2J,R3L),(ZA,R1P,R2J,R3M),(ZA,R1P,R2J,R3N),
(ZA,R1P,R2J,R3O),(ZA,R1P,R2J,R3P),(ZA,R1P,R2J,R3Q),
(ZA,R1P,R2J,R3R),(ZA,R1P,R2K,R3A),(ZA,R1P,R2K,R3B),
(ZA,R1P,R2K,R3C),(ZA,R1P,R2K,R3D),(ZA,R1P,R2K,R3E),
(ZA,R1P,R2K,R3F),(ZA,R1P,R2K,R3G),(ZA,R1P,R2K,R3H),
(ZA,R1P,R2K,R3I),(ZA,R1P,R2K,R3J),(ZA,R1P,R2K,R3K),
(ZA,R1P,R2K,R3L),(ZA,R1P,R2K,R3M),(ZA,R1P,R2K,R3N),
(ZA,R1P,R2K,R3O),(ZA,R1P,R2K,R3P),(ZA,R1P,R2K,R3Q),
(ZA,R1P,R2K,R3R),(ZA,R1P,R2L,R3A),(ZA,R1P,R2L,R3B),
(ZA,R1P,R2L,R3C),(ZA,R1P,R2L,R3D),(ZA,R1P,R2L,R3E),
(ZA,R1P,R2L,R3F),(ZA,R1P,R2L,R3G),(ZA,R1P,R2L,R3H),
(ZA,R1P,R2L,R3I),(ZA,R1P,R2L,R3J),(ZA,R1P,R2L,R3K),
(ZA,R1P,R2L,R3L),(ZA,R1P,R2L,R3M),(ZA,R1P,R2L,R3N),
(ZA,R1P,R2L,R3O),(ZA,R1P,R2L,R3P),(ZA,R1P,R2L,R3Q),
(ZA,R1P,R2L,R3R),(ZA,R1P,R2M,R3A),(ZA,R1P,R2M,R3B),
(ZA,R1P,R2M,R3C),(ZA,R1P,R2M,R3D),(ZA,R1P,R2M,R3E),
(ZA,R1P,R2M,R3F),(ZA,R1P,R2M,R3G),(ZA,R1P,R2M,R3H),
(ZA,R1P,R2M,R3I),(ZA,R1P,R2M,R3J),(ZA,R1P,R2M,R3K),
(ZA,R1P,R2M,R3L),(ZA,R1P,R2M,R3M),(ZA,R1P,R2M,R3N),
(ZA,R1P,R2M,R3O),(ZA,R1P,R2M,R3P),(ZA,R1P,R2M,R3Q),
(ZA,R1P,R2M,R3R),(ZA,R1P,R2N,R3A),(ZA,R1P,R2N,R3B),
(ZA,R1P,R2N,R3C),(ZA,R1P,R2N,R3D),(ZA,R1P,R2N,R3E),
(ZA,R1P,R2N,R3F),(ZA,R1P,R2N,R3G),(ZA,R1P,R2N,R3H),
(ZA,R1P,R2N,R3I),(ZA,R1P,R2N,R3J),(ZA,R1P,R2N,R3K),
(ZA,R1P,R2N,R3L),(ZA,R1P,R2N,R3M),(ZA,R1P,R2N,R3N),
(ZA,R1P,R2N,R3O),(ZA,R1P,R2N,R3P),(ZA,R1P,R2N,R3Q),
(ZA,R1P,R2N,R3R),(ZA,R1Q,R2A,R3A),(ZA,R1Q,R2A,R3B),
(ZA,R1Q,R2A,R3C),(ZA,R1Q,R2A,R3D),(ZA,R1Q,R2A,R3E),
(ZA,R1Q,R2A,R3F),(ZA,R1Q,R2A,R3G),(ZA,R1Q,R2A,R3H),
(ZA,R1Q,R2A,R3I),(ZA,R1Q,R2A,R3J),(ZA,R1Q,R2A,R3K),
(ZA,R1Q,R2A,R3L),(ZA,R1Q,R2A,R3M),(ZA,R1Q,R2A,R3N),
(ZA,R1Q,R2A,R3O),(ZA,R1Q,R2A,R3P),(ZA,R1Q,R2A,R3Q),
(ZA,R1Q,R2A,R3R),(ZA,R1Q,R2B,R3A),(ZA,R1Q,R2B,R3B),
(ZA,R1Q,R2B,R3C),(ZA,R1Q,R2B,R3D),(ZA,R1Q,R2B,R3E),
(ZA,R1Q,R2B,R3F),(ZA,R1Q,R2B,R3G),(ZA,R1Q,R2B,R3H),
(ZA,R1Q,R2B,R3I),(ZA,R1Q,R2B,R3J),(ZA,R1Q,R2B,R3K),
(ZA,R1Q,R2B,R3L),(ZA,R1Q,R2B,R3M),(ZA,R1Q,R2B,R3N),
(ZA,R1Q,R2B,R3O),(ZA,R1Q,R2B,R3P),(ZA,R1Q,R2B,R3Q),
(ZA,R1Q,R2B,R3R),(ZA,R1Q,R2C,R3A),(ZA,R1Q,R2C,R3B),
(ZA,R1Q,R2C,R3C),(ZA,R1Q,R2C,R3D),(ZA,R1Q,R2C,R3E),
(ZA,R1Q,R2C,R3F),(ZA,R1Q,R2C,R3G),(ZA,R1Q,R2C,R3H),
(ZA,R1Q,R2C,R3I),(ZA,R1Q,R2C,R3J),(ZA,R1Q,R2C,R3K),
(ZA,R1Q,R2C,R3L),(ZA,R1Q,R2C,R3M),(ZA,R1Q,R2C,R3N),
(ZA,R1Q,R2C,R3O),(ZA,R1Q,R2C,R3P),(ZA,R1Q,R2C,R3Q),
(ZA,R1Q,R2C,R3R),(ZA,R1Q,R2D,R3A),(ZA,R1Q,R2D,R3B),
(ZA,R1Q,R2D,R3C),(ZA,R1Q,R2D,R3D),(ZA,R1Q,R2D,R3E),
(ZA,R1Q,R2D,R3F),(ZA,R1Q,R2D,R3G),(ZA,R1Q,R2D,R3H),
(ZA,R1Q,R2D,R3I),(ZA,R1Q,R2D,R3J),(ZA,R1Q,R2D,R3K),
(ZA,R1Q,R2D,R3L),(ZA,R1Q,R2D,R3M),(ZA,R1Q,R2D,R3N),
(ZA,R1Q,R2D,R3O),(ZA,R1Q,R2D,R3P),(ZA,R1Q,R2D,R3Q),
(ZA,R1Q,R2D,R3R),(ZA,R1Q,R2E,R3A),(ZA,R1Q,R2E,R3B),
(ZA,R1Q,R2E,R3C),(ZA,R1Q,R2E,R3D),(ZA,R1Q,R2E,R3E),
(ZA,R1Q,R2E,R3F),(ZA,R1Q,R2E,R3G),(ZA,R1Q,R2E,R3H),
(ZA,R1Q,R2E,R3I),(ZA,R1Q,R2E,R3J),(ZA,R1Q,R2E,R3K),
(ZA,R1Q,R2E,R3L),(ZA,R1Q,R2E,R3M),(ZA,R1Q,R2E,R3N),
(ZA,R1Q,R2E,R3O),(ZA,R1Q,R2E,R3P),(ZA,R1Q,R2E,R3Q),
(ZA,R1Q,R2E,R3R),(ZA,R1Q,R2F,R3A),(ZA,R1Q,R2F,R3B),
(ZA,R1Q,R2F,R3C),(ZA,R1Q,R2F,R3D),(ZA,R1Q,R2F,R3E),
(ZA,R1Q,R2F,R3F),(ZA,R1Q,R2F,R3G),(ZA,R1Q,R2F,R3H),
(ZA,R1Q,R2F,R3I),(ZA,R1Q,R2F,R3J),(ZA,R1Q,R2F,R3K),
(ZA,R1Q,R2F,R3L),(ZA,R1Q,R2F,R3M),(ZA,R1Q,R2F,R3N),
(ZA,R1Q,R2F,R3O),(ZA,R1Q,R2F,R3P),(ZA,R1Q,R2F,R3Q),
(ZA,R1Q,R2F,R3R),(ZA,R1Q,R2G,R3A),(ZA,R1Q,R2G,R3B),
(ZA,R1Q,R2G,R3C),(ZA,R1Q,R2G,R3D),(ZA,R1Q,R2G,R3E),
(ZA,R1Q,R2G,R3F),(ZA,R1Q,R2G,R3G),(ZA,R1Q,R2G,R3H),
(ZA,R1Q,R2G,R3I),(ZA,R1Q,R2G,R3J),(ZA,R1Q,R2G,R3K),
(ZA,R1Q,R2G,R3L),(ZA,R1Q,R2G,R3M),(ZA,R1Q,R2G,R3N),
(ZA,R1Q,R2G,R3O),(ZA,R1Q,R2G,R3P),(ZA,R1Q,R2G,R3Q),
(ZA,R1Q,R2G,R3R),(ZA,R1Q,R2H,R3A),(ZA,R1Q,R2H,R3B),
(ZA,R1Q,R2H,R3C),(ZA,R1Q,R2H,R3D),(ZA,R1Q,R2H,R3E),
(ZA,R1Q,R2H,R3F),(ZA,R1Q,R2H,R3G),(ZA,R1Q,R2H,R3H),
(ZA,R1Q,R2H,R3I),(ZA,R1Q,R2H,R3J),(ZA,R1Q,R2H,R3K),
(ZA,R1Q,R2H,R3L),(ZA,R1Q,R2H,R3M),(ZA,R1Q,R2H,R3N),
(ZA,R1Q,R2H,R3O),(ZA,R1Q,R2H,R3P),(ZA,R1Q,R2H,R3Q),
(ZA,R1Q,R2H,R3R),(ZA,R1Q,R2I,R3A),(ZA,R1Q,R2I,R3B),
(ZA,R1Q,R2I,R3C),(ZA,R1Q,R2I,R3D),(ZA,R1Q,R2I,R3E),
(ZA,R1Q,R2I,R3F),(ZA,R1Q,R2I,R3G),(ZA,R1Q,R2I,R3H),
(ZA,R1Q,R2I,R3I),(ZA,R1Q,R2I,R3J),(ZA,R1Q,R2I,R3K),
(ZA,R1Q,R2I,R3L),(ZA,R1Q,R2I,R3M),(ZA,R1Q,R2I,R3N),
(ZA,R1Q,R2I,R3O),(ZA,R1Q,R2I,R3P),(ZA,R1Q,R2I,R3Q),
(ZA,R1Q,R2I,R3R),(ZA,R1Q,R2J,R3A),(ZA,R1Q,R2J,R3B),
(ZA,R1Q,R2J,R3C),(ZA,R1Q,R2J,R3D),(ZA,R1Q,R2J,R3E),
(ZA,R1Q,R2J,R3F),(ZA,R1Q,R2J,R3G),(ZA,R1Q,R2J,R3H),
(ZA,R1Q,R2J,R3I),(ZA,R1Q,R2J,R3J),(ZA,R1Q,R2J,R3K),
(ZA,R1Q,R2J,R3L),(ZA,R1Q,R2J,R3M),(ZA,R1Q,R2J,R3N),
(ZA,R1Q,R2J,R3O),(ZA,R1Q,R2J,R3P),(ZA,R1Q,R2J,R3Q),
(ZA,R1Q,R2J,R3R),(ZA,R1Q,R2K,R3A),(ZA,R1Q,R2K,R3B),
(ZA,R1Q,R2K,R3C),(ZA,R1Q,R2K,R3D),(ZA,R1Q,R2K,R3E),
(ZA,R1Q,R2K,R3F),(ZA,R1Q,R2K,R3G),(ZA,R1Q,R2K,R3H),
(ZA,R1Q,R2K,R3I),(ZA,R1Q,R2K,R3J),(ZA,R1Q,R2K,R3K),
(ZA,R1Q,R2K,R3L),(ZA,R1Q,R2K,R3M),(ZA,R1Q,R2K,R3N),
(ZA,R1Q,R2K,R3O),(ZA,R1Q,R2K,R3P),(ZA,R1Q,R2K,R3Q),
(ZA,R1Q,R2K,R3R),(ZA,R1Q,R2L,R3A),(ZA,R1Q,R2L,R3B),
(ZA,R1Q,R2L,R3C),(ZA,R1Q,R2L,R3D),(ZA,R1Q,R2L,R3E),
(ZA,R1Q,R2L,R3F),(ZA,R1Q,R2L,R3G),(ZA,R1Q,R2L,R3H),
(ZA,R1Q,R2L,R3I),(ZA,R1Q,R2L,R3J),(ZA,R1Q,R2L,R3K),
(ZA,R1Q,R2L,R3L),(ZA,R1Q,R2L,R3M),(ZA,R1Q,R2L,R3N),
(ZA,R1Q,R2L,R3O),(ZA,R1Q,R2L,R3P),(ZA,R1Q,R2L,R3Q),
(ZA,R1Q,R2L,R3R),(ZA,R1Q,R2M,R3A),(ZA,R1Q,R2M,R3B),
(ZA,R1Q,R2M,R3C),(ZA,R1Q,R2M,R3D),(ZA,R1Q,R2M,R3E),
(ZA,R1Q,R2M,R3F),(ZA,R1Q,R2M,R3G),(ZA,R1Q,R2M,R3H),
(ZA,R1Q,R2M,R3I),(ZA,R1Q,R2M,R3J),(ZA,R1Q,R2M,R3K),
(ZA,R1Q,R2M,R3L),(ZA,R1Q,R2M,R3M),(ZA,R1Q,R2M,R3N),
(ZA,R1Q,R2M,R3O),(ZA,R1Q,R2M,R3P),(ZA,R1Q,R2M,R3Q),
(ZA,R1Q,R2M,R3R),(ZA,R1Q,R2N,R3A),(ZA,R1Q,R2N,R3B),
(ZA,R1Q,R2N,R3C),(ZA,R1Q,R2N,R3D),(ZA,R1Q,R2N,R3E),
(ZA,R1Q,R2N,R3F),(ZA,R1Q,R2N,R3G),(ZA,R1Q,R2N,R3H),
(ZA,R1Q,R2N,R3I),(ZA,R1Q,R2N,R3J),(ZA,R1Q,R2N,R3K),
(ZA,R1Q,R2N,R3L),(ZA,R1Q,R2N,R3M),(ZA,R1Q,R2N,R3N),
(ZA,R1Q,R2N,R3O),(ZA,R1Q,R2N,R3P),(ZA,R1Q,R2N,R3Q),
(ZA,R1Q,R2N,R3R),(ZA,R1R,R2A,R3A),(ZA,R1R,R2A,R3B),
(ZA,R1R,R2A,R3C),(ZA,R1R,R2A,R3D),(ZA,R1R,R2A,R3E),
(ZA,R1R,R2A,R3F),(ZA,R1R,R2A,R3G),(ZA,R1R,R2A,R3H),
(ZA,R1R,R2A,R3I),(ZA,R1R,R2A,R3J),(ZA,R1R,R2A,R3K),
(ZA,R1R,R2A,R3L),(ZA,R1R,R2A,R3M),(ZA,R1R,R2A,R3N),
(ZA,R1R,R2A,R3O),(ZA,R1R,R2A,R3P),(ZA,R1R,R2A,R3Q),
(ZA,R1R,R2A,R3R),(ZA,R1R,R2B,R3A),(ZA,R1R,R2B,R3B),
(ZA,R1R,R2B,R3C),(ZA,R1R,R2B,R3D),(ZA,R1R,R2B,R3E),
(ZA,R1R,R2B,R3F),(ZA,R1R,R2B,R3G),(ZA,R1R,R2B,R3H),
(ZA,R1R,R2B,R3I),(ZA,R1R,R2B,R3J),(ZA,R1R,R2B,R3K),
(ZA,R1R,R2B,R3L),(ZA,R1R,R2B,R3M),(ZA,R1R,R2B,R3N),
(ZA,R1R,R2B,R3O),(ZA,R1R,R2B,R3P),(ZA,R1R,R2B,R3Q),
(ZA,R1R,R2B,R3R),(ZA,R1R,R2C,R3A),(ZA,R1R,R2C,R3B),
(ZA,R1R,R2C,R3C),(ZA,R1R,R2C,R3D),(ZA,R1R,R2C,R3E),
(ZA,R1R,R2C,R3F),(ZA,R1R,R2C,R3G),(ZA,R1R,R2C,R3H),
(ZA,R1R,R2C,R3I),(ZA,R1R,R2C,R3J),(ZA,R1R,R2C,R3K),
(ZA,R1R,R2C,R3L),(ZA,R1R,R2C,R3M),(ZA,R1R,R2C,R3N),
(ZA,R1R,R2C,R3O),(ZA,R1R,R2C,R3P),(ZA,R1R,R2C,R3Q),
(ZA,R1R,R2C,R3R),(ZA,R1R,R2D,R3A),(ZA,R1R,R2D,R3B),
(ZA,R1R,R2D,R3C),(ZA,R1R,R2D,R3D),(ZA,R1R,R2D,R3E),
(ZA,R1R,R2D,R3F),(ZA,R1R,R2D,R3G),(ZA,R1R,R2D,R3H),
(ZA,R1R,R2D,R3I),(ZA,R1R,R2D,R3J),(ZA,R1R,R2D,R3K),
(ZA,R1R,R2D,R3L),(ZA,R1R,R2D,R3M),(ZA,R1R,R2D,R3N),
(ZA,R1R,R2D,R3O),(ZA,R1R,R2D,R3P),(ZA,R1R,R2D,R3Q),
(ZA,R1R,R2D,R3R),(ZA,R1R,R2E,R3A),(ZA,R1R,R2E,R3B),
(ZA,R1R,R2E,R3C),(ZA,R1R,R2E,R3D),(ZA,R1R,R2E,R3E),
(ZA,R1R,R2E,R3F),(ZA,R1R,R2E,R3G),(ZA,R1R,R2E,R3H),
(ZA,R1R,R2E,R3I),(ZA,R1R,R2E,R3J),(ZA,R1R,R2E,R3K),
(ZA,R1R,R2E,R3L),(ZA,R1R,R2E,R3M),(ZA,R1R,R2E,R3N),
(ZA,R1R,R2E,R3O),(ZA,R1R,R2E,R3P),(ZA,R1R,R2E,R3Q),
(ZA,R1R,R2E,R3R),(ZA,R1R,R2F,R3A),(ZA,R1R,R2F,R3B),
(ZA,R1R,R2F,R3C),(ZA,R1R,R2F,R3D),(ZA,R1R,R2F,R3E),
(ZA,R1R,R2F,R3F),(ZA,R1R,R2F,R3G),(ZA,R1R,R2F,R3H),
(ZA,R1R,R2F,R3I),(ZA,R1R,R2F,R3J),(ZA,R1R,R2F,R3K),
(ZA,R1R,R2F,R3L),(ZA,R1R,R2F,R3M),(ZA,R1R,R2F,R3N),
(ZA,R1R,R2F,R3O),(ZA,R1R,R2F,R3P),(ZA,R1R,R2F,R3Q),
(ZA,R1R,R2F,R3R),(ZA,R1R,R2G,R3A),(ZA,R1R,R2G,R3B),
(ZA,R1R,R2G,R3C),(ZA,R1R,R2G,R3D),(ZA,R1R,R2G,R3E),
(ZA,R1R,R2G,R3F),(ZA,R1R,R2G,R3G),(ZA,R1R,R2G,R3H),
(ZA,R1R,R2G,R3I),(ZA,R1R,R2G,R3J),(ZA,R1R,R2G,R3K),
(ZA,R1R,R2G,R3L),(ZA,R1R,R2G,R3M),(ZA,R1R,R2G,R3N),
(ZA,R1R,R2G,R3O),(ZA,R1R,R2G,R3P),(ZA,R1R,R2G,R3Q),
(ZA,R1R,R2G,R3R),(ZA,R1R,R2H,R3A),(ZA,R1R,R2H,R3B),
(ZA,R1R,R2H,R3C),(ZA,R1R,R2H,R3D),(ZA,R1R,R2H,R3E),
(ZA,R1R,R2H,R3F),(ZA,R1R,R2H,R3G),(ZA,R1R,R2H,R3H),
(ZA,R1R,R2H,R3I),(ZA,R1R,R2H,R3J),(ZA,R1R,R2H,R3K),
(ZA,R1R,R2H,R3L),(ZA,R1R,R2H,R3M),(ZA,R1R,R2H,R3N),
(ZA,R1R,R2H,R3O),(ZA,R1R,R2H,R3P),(ZA,R1R,R2H,R3Q),
(ZA,R1R,R2H,R3R),(ZA,R1R,R2I,R3A),(ZA,R1R,R2I,R3B),
(ZA,R1R,R2I,R3C),(ZA,R1R,R2I,R3D),(ZA,R1R,R2I,R3E),
(ZA,R1R,R2I,R3F),(ZA,R1R,R2I,R3G),(ZA,R1R,R2I,R3H),
(ZA,R1R,R2I,R3I),(ZA,R1R,R2I,R3J),(ZA,R1R,R2I,R3K),
(ZA,R1R,R2I,R3L),(ZA,R1R,R2I,R3M),(ZA,R1R,R2I,R3N),
(ZA,R1R,R2I,R3O),(ZA,R1R,R2I,R3P),(ZA,R1R,R2I,R3Q),
(ZA,R1R,R2I,R3R),(ZA,R1R,R2J,R3A),(ZA,R1R,R2J,R3B),
(ZA,R1R,R2J,R3C),(ZA,R1R,R2J,R3D),(ZA,R1R,R2J,R3E),
(ZA,R1R,R2J,R3F),(ZA,R1R,R2J,R3G),(ZA,R1R,R2J,R3H),
(ZA,R1R,R2J,R3I),(ZA,R1R,R2J,R3J),(ZA,R1R,R2J,R3K),
(ZA,R1R,R2J,R3L),(ZA,R1R,R2J,R3M),(ZA,R1R,R2J,R3N),
(ZA,R1R,R2J,R3O),(ZA,R1R,R2J,R3P),(ZA,R1R,R2J,R3Q),
(ZA,R1R,R2J,R3R),(ZA,R1R,R2K,R3A),(ZA,R1R,R2K,R3B),
(ZA,R1R,R2K,R3C),(ZA,R1R,R2K,R3D),(ZA,R1R,R2K,R3E),
(ZA,R1R,R2K,R3F),(ZA,R1R,R2K,R3G),(ZA,R1R,R2K,R3H),
(ZA,R1R,R2K,R3I),(ZA,R1R,R2K,R3J),(ZA,R1R,R2K,R3K),
(ZA,R1R,R2K,R3L),(ZA,R1R,R2K,R3M),(ZA,R1R,R2K,R3N),
(ZA,R1R,R2K,R3O),(ZA,R1R,R2K,R3P),(ZA,R1R,R2K,R3Q),
(ZA,R1R,R2K,R3R),(ZA,R1R,R2L,R3A),(ZA,R1R,R2L,R3B),
(ZA,R1R,R2L,R3C),(ZA,R1R,R2L,R3D),(ZA,R1R,R2L,R3E),
(ZA,R1R,R2L,R3F),(ZA,R1R,R2L,R3G),(ZA,R1R,R2L,R3H),
(ZA,R1R,R2L,R3I),(ZA,R1R,R2L,R3J),(ZA,R1R,R2L,R3K),
(ZA,R1R,R2L,R3L),(ZA,R1R,R2L,R3M),(ZA,R1R,R2L,R3N),
(ZA,R1R,R2L,R3O),(ZA,R1R,R2L,R3P),(ZA,R1R,R2L,R3Q),
(ZA,R1R,R2L,R3R),(ZA,R1R,R2M,R3A),(ZA,R1R,R2M,R3B),
(ZA,R1R,R2M,R3C),(ZA,R1R,R2M,R3D),(ZA,R1R,R2M,R3E),
(ZA,R1R,R2M,R3F),(ZA,R1R,R2M,R3G),(ZA,R1R,R2M,R3H),
(ZA,R1R,R2M,R3I),(ZA,R1R,R2M,R3J),(ZA,R1R,R2M,R3K),
(ZA,R1R,R2M,R3L),(ZA,R1R,R2M,R3M),(ZA,R1R,R2M,R3N),
(ZA,R1R,R2M,R3O),(ZA,R1R,R2M,R3P),(ZA,R1R,R2M,R3Q),
(ZA,R1R,R2M,R3R),(ZA,R1R,R2N,R3A),(ZA,R1R,R2N,R3B),
(ZA,R1R,R2N,R3C),(ZA,R1R,R2N,R3D),(ZA,R1R,R2N,R3E),
(ZA,R1R,R2N,R3F),(ZA,R1R,R2N,R3G),(ZA,R1R,R2N,R3H),
(ZA,R1R,R2N,R3I),(ZA,R1R,R2N,R3J),(ZA,R1R,R2N,R3K),
(ZA,R1R,R2N,R3L),(ZA,R1R,R2N,R3M),(ZA,R1R,R2N,R3N),
(ZA,R1R,R2N,R3O),(ZA,R1R,R2N,R3P),(ZA,R1R,R2N,R3Q),
(ZA,R1R,R2N,R3R),(ZA,R1S,R2A,R3A),(ZA,R1S,R2A,R3B),
(ZA,R1S,R2A,R3C),(ZA,R1S,R2A,R3D),(ZA,R1S,R2A,R3E),
(ZA,R1S,R2A,R3F),(ZA,R1S,R2A,R3G),(ZA,R1S,R2A,R3H),
(ZA,R1S,R2A,R3I),(ZA,R1S,R2A,R3J),(ZA,R1S,R2A,R3K),
(ZA,R1S,R2A,R3L),(ZA,R1S,R2A,R3M),(ZA,R1S,R2A,R3N),
(ZA,R1S,R2A,R3O),(ZA,R1S,R2A,R3P),(ZA,R1S,R2A,R3Q),
(ZA,R1S,R2A,R3R),(ZA,R1S,R2B,R3A),(ZA,R1S,R2B,R3B),
(ZA,R1S,R2B,R3C),(ZA,R1S,R2B,R3D),(ZA,R1S,R2B,R3E),
(ZA,R1S,R2B,R3F),(ZA,R1S,R2B,R3G),(ZA,R1S,R2B,R3H),
(ZA,R1S,R2B,R3I),(ZA,R1S,R2B,R3J),(ZA,R1S,R2B,R3K),
(ZA,R1S,R2B,R3L),(ZA,R1S,R2B,R3M),(ZA,R1S,R2B,R3N),
(ZA,R1S,R2B,R3O),(ZA,R1S,R2B,R3P),(ZA,R1S,R2B,R3Q),
(ZA,R1S,R2B,R3R),(ZA,R1S,R2C,R3A),(ZA,R1S,R2C,R3B),
(ZA,R1S,R2C,R3C),(ZA,R1S,R2C,R3D),(ZA,R1S,R2C,R3E),
(ZA,R1S,R2C,R3F),(ZA,R1S,R2C,R3G),(ZA,R1S,R2C,R3H),
(ZA,R1S,R2C,R3I),(ZA,R1S,R2C,R3J),(ZA,R1S,R2C,R3K),
(ZA,R1S,R2C,R3L),(ZA,R1S,R2C,R3M),(ZA,R1S,R2C,R3N),
(ZA,R1S,R2C,R3O),(ZA,R1S,R2C,R3P),(ZA,R1S,R2C,R3Q),
(ZA,R1S,R2C,R3R),(ZA,R1S,R2D,R3A),(ZA,R1S,R2D,R3B),
(ZA,R1S,R2D,R3C),(ZA,R1S,R2D,R3D),(ZA,R1S,R2D,R3E),
(ZA,R1S,R2D,R3F),(ZA,R1S,R2D,R3G),(ZA,R1S,R2D,R3H),
(ZA,R1S,R2D,R3I),(ZA,R1S,R2D,R3J),(ZA,R1S,R2D,R3K),
(ZA,R1S,R2D,R3L),(ZA,R1S,R2D,R3M),(ZA,R1S,R2D,R3N),
(ZA,R1S,R2D,R3O),(ZA,R1S,R2D,R3P),(ZA,R1S,R2D,R3Q),
(ZA,R1S,R2D,R3R),(ZA,R1S,R2E,R3A),(ZA,R1S,R2E,R3B),
(ZA,R1S,R2E,R3C),(ZA,R1S,R2E,R3D),(ZA,R1S,R2E,R3E),
(ZA,R1S,R2E,R3F),(ZA,R1S,R2E,R3G),(ZA,R1S,R2E,R3H),
(ZA,R1S,R2E,R3I),(ZA,R1S,R2E,R3J),(ZA,R1S,R2E,R3K),
(ZA,R1S,R2E,R3L),(ZA,R1S,R2E,R3M),(ZA,R1S,R2E,R3N),
(ZA,R1S,R2E,R3O),(ZA,R1S,R2E,R3P),(ZA,R1S,R2E,R3Q),
(ZA,R1S,R2E,R3R),(ZA,R1S,R2F,R3A),(ZA,R1S,R2F,R3B),
(ZA,R1S,R2F,R3C),(ZA,R1S,R2F,R3D),(ZA,R1S,R2F,R3E),
(ZA,R1S,R2F,R3F),(ZA,R1S,R2F,R3G),(ZA,R1S,R2F,R3H),
(ZA,R1S,R2F,R3I),(ZA,R1S,R2F,R3J),(ZA,R1S,R2F,R3K),
(ZA,R1S,R2F,R3L),(ZA,R1S,R2F,R3M),(ZA,R1S,R2F,R3N),
(ZA,R1S,R2F,R3O),(ZA,R1S,R2F,R3P),(ZA,R1S,R2F,R3Q),
(ZA,R1S,R2F,R3R),(ZA,R1S,R2G,R3A),(ZA,R1S,R2G,R3B),
(ZA,R1S,R2G,R3C),(ZA,R1S,R2G,R3D),(ZA,R1S,R2G,R3E),
(ZA,R1S,R2G,R3F),(ZA,R1S,R2G,R3G),(ZA,R1S,R2G,R3H),
(ZA,R1S,R2G,R3I),(ZA,R1S,R2G,R3J),(ZA,R1S,R2G,R3K),
(ZA,R1S,R2G,R3L),(ZA,R1S,R2G,R3M),(ZA,R1S,R2G,R3N),
(ZA,R1S,R2G,R3O),(ZA,R1S,R2G,R3P),(ZA,R1S,R2G,R3Q),
(ZA,R1S,R2G,R3R),(ZA,R1S,R2H,R3A),(ZA,R1S,R2H,R3B),
(ZA,R1S,R2H,R3C),(ZA,R1S,R2H,R3D),(ZA,R1S,R2H,R3E),
(ZA,R1S,R2H,R3F),(ZA,R1S,R2H,R3G),(ZA,R1S,R2H,R3H),
(ZA,R1S,R2H,R3I),(ZA,R1S,R2H,R3J),(ZA,R1S,R2H,R3K),
(ZA,R1S,R2H,R3L),(ZA,R1S,R2H,R3M),(ZA,R1S,R2H,R3N),
(ZA,R1S,R2H,R3O),(ZA,R1S,R2H,R3P),(ZA,R1S,R2H,R3Q),
(ZA,R1S,R2H,R3R),(ZA,R1S,R2I,R3A),(ZA,R1S,R2I,R3B),
(ZA,R1S,R2I,R3C),(ZA,R1S,R2I,R3D),(ZA,R1S,R2I,R3E),
(ZA,R1S,R2I,R3F),(ZA,R1S,R2I,R3G),(ZA,R1S,R2I,R3H),
(ZA,R1S,R2I,R3I),(ZA,R1S,R2I,R3J),(ZA,R1S,R2I,R3K),
(ZA,R1S,R2I,R3L),(ZA,R1S,R2I,R3M),(ZA,R1S,R2I,R3N),
(ZA,R1S,R2I,R3O),(ZA,R1S,R2I,R3P),(ZA,R1S,R2I,R3Q),
(ZA,R1S,R2I,R3R),(ZA,R1S,R2J,R3A),(ZA,R1S,R2J,R3B),
(ZA,R1S,R2J,R3C),(ZA,R1S,R2J,R3D),(ZA,R1S,R2J,R3E),
(ZA,R1S,R2J,R3F),(ZA,R1S,R2J,R3G),(ZA,R1S,R2J,R3H),
(ZA,R1S,R2J,R3I),(ZA,R1S,R2J,R3J),(ZA,R1S,R2J,R3K),
(ZA,R1S,R2J,R3L),(ZA,R1S,R2J,R3M),(ZA,R1S,R2J,R3N),
(ZA,R1S,R2J,R3O),(ZA,R1S,R2J,R3P),(ZA,R1S,R2J,R3Q),
(ZA,R1S,R2J,R3R),(ZA,R1S,R2K,R3A),(ZA,R1S,R2K,R3B),
(ZA,R1S,R2K,R3C),(ZA,R1S,R2K,R3D),(ZA,R1S,R2K,R3E),
(ZA,R1S,R2K,R3F),(ZA,R1S,R2K,R3G),(ZA,R1S,R2K,R3H),
(ZA,R1S,R2K,R3I),(ZA,R1S,R2K,R3J),(ZA,R1S,R2K,R3K),
(ZA,R1S,R2K,R3L),(ZA,R1S,R2K,R3M),(ZA,R1S,R2K,R3N),
(ZA,R1S,R2K,R3O),(ZA,R1S,R2K,R3P),(ZA,R1S,R2K,R3Q),
(ZA,R1S,R2K,R3R),(ZA,R1S,R2L,R3A),(ZA,R1S,R2L,R3B),
(ZA,R1S,R2L,R3C),(ZA,R1S,R2L,R3D),(ZA,R1S,R2L,R3E),
(ZA,R1S,R2L,R3F),(ZA,R1S,R2L,R3G),(ZA,R1S,R2L,R3H),
(ZA,R1S,R2L,R3I),(ZA,R1S,R2L,R3J),(ZA,R1S,R2L,R3K),
(ZA,R1S,R2L,R3L),(ZA,R1S,R2L,R3M),(ZA,R1S,R2L,R3N),
(ZA,R1S,R2L,R3O),(ZA,R1S,R2L,R3P),(ZA,R1S,R2L,R3Q),
(ZA,R1S,R2L,R3R),(ZA,R1S,R2M,R3A),(ZA,R1S,R2M,R3B),
(ZA,R1S,R2M,R3C),(ZA,R1S,R2M,R3D),(ZA,R1S,R2M,R3E),
(ZA,R1S,R2M,R3F),(ZA,R1S,R2M,R3G),(ZA,R1S,R2M,R3H),
(ZA,R1S,R2M,R3I),(ZA,R1S,R2M,R3J),(ZA,R1S,R2M,R3K),
(ZA,R1S,R2M,R3L),(ZA,R1S,R2M,R3M),(ZA,R1S,R2M,R3N),
(ZA,R1S,R2M,R3O),(ZA,R1S,R2M,R3P),(ZA,R1S,R2M,R3Q),
(ZA,R1S,R2M,R3R),(ZA,R1S,R2N,R3A),(ZA,R1S,R2N,R3B),
(ZA,R1S,R2N,R3C),(ZA,R1S,R2N,R3D),(ZA,R1S,R2N,R3E),
(ZA,R1S,R2N,R3F),(ZA,R1S,R2N,R3G),(ZA,R1S,R2N,R3H),
(ZA,R1S,R2N,R3I),(ZA,R1S,R2N,R3J),(ZA,R1S,R2N,R3K),
(ZA,R1S,R2N,R3L),(ZA,R1S,R2N,R3M),(ZA,R1S,R2N,R3N),
(ZA,R1S,R2N,R3O),(ZA,R1S,R2N,R3P),(ZA,R1S,R2N,R3Q),
(ZA,R1S,R2N,R3R),(ZB,R1A,R2A,R3A),(ZB,R1A,R2A,R3B),
(ZB,R1A,R2A,R3C),(ZB,R1A,R2A,R3D),(ZB,R1A,R2A,R3E),
(ZB,R1A,R2A,R3F),(ZB,R1A,R2A,R3G),(ZB,R1A,R2A,R3H),
(ZB,R1A,R2A,R3I),(ZB,R1A,R2A,R3J),(ZB,R1A,R2A,R3K),
(ZB,R1A,R2A,R3L),(ZB,R1A,R2A,R3M),(ZB,R1A,R2A,R3N),
(ZB,R1A,R2A,R3O),(ZB,R1A,R2A,R3P),(ZB,R1A,R2A,R3Q),
(ZB,R1A,R2A,R3R),(ZB,R1A,R2B,R3A),(ZB,R1A,R2B,R3B),
(ZB,R1A,R2B,R3C),(ZB,R1A,R2B,R3D),(ZB,R1A,R2B,R3E),
(ZB,R1A,R2B,R3F),(ZB,R1A,R2B,R3G),(ZB,R1A,R2B,R3H),
(ZB,R1A,R2B,R3I),(ZB,R1A,R2B,R3J),(ZB,R1A,R2B,R3K),
(ZB,R1A,R2B,R3L),(ZB,R1A,R2B,R3M),(ZB,R1A,R2B,R3N),
(ZB,R1A,R2B,R3O),(ZB,R1A,R2B,R3P),(ZB,R1A,R2B,R3Q),
(ZB,R1A,R2B,R3R),(ZB,R1A,R2C,R3A),(ZB,R1A,R2C,R3B),
(ZB,R1A,R2C,R3C),(ZB,R1A,R2C,R3D),(ZB,R1A,R2C,R3E),
(ZB,R1A,R2C,R3F),(ZB,R1A,R2C,R3G),(ZB,R1A,R2C,R3H),
(ZB,R1A,R2C,R3I),(ZB,R1A,R2C,R3J),(ZB,R1A,R2C,R3K),
(ZB,R1A,R2C,R3L),(ZB,R1A,R2C,R3M),(ZB,R1A,R2C,R3N),
(ZB,R1A,R2C,R3O),(ZB,R1A,R2C,R3P),(ZB,R1A,R2C,R3Q),
(ZB,R1A,R2C,R3R),(ZB,R1A,R2D,R3A),(ZB,R1A,R2D,R3B),
(ZB,R1A,R2D,R3C),(ZB,R1A,R2D,R3D),(ZB,R1A,R2D,R3E),
(ZB,R1A,R2D,R3F),(ZB,R1A,R2D,R3G),(ZB,R1A,R2D,R3H),
(ZB,R1A,R2D,R3I),(ZB,R1A,R2D,R3J),(ZB,R1A,R2D,R3K),
(ZB,R1A,R2D,R3L),(ZB,R1A,R2D,R3M),(ZB,R1A,R2D,R3N),
(ZB,R1A,R2D,R3O),(ZB,R1A,R2D,R3P),(ZB,R1A,R2D,R3Q),
(ZB,R1A,R2D,R3R),(ZB,R1A,R2E,R3A),(ZB,R1A,R2E,R3B),
(ZB,R1A,R2E,R3C),(ZB,R1A,R2E,R3D),(ZB,R1A,R2E,R3E),
(ZB,R1A,R2E,R3F),(ZB,R1A,R2E,R3G),(ZB,R1A,R2E,R3H),
(ZB,R1A,R2E,R3I),(ZB,R1A,R2E,R3J),(ZB,R1A,R2E,R3K),
(ZB,R1A,R2E,R3L),(ZB,R1A,R2E,R3M),(ZB,R1A,R2E,R3N),
(ZB,R1A,R2E,R3O),(ZB,R1A,R2E,R3P),(ZB,R1A,R2E,R3Q),
(ZB,R1A,R2E,R3R),(ZB,R1A,R2F,R3A),(ZB,R1A,R2F,R3B),
(ZB,R1A,R2F,R3C),(ZB,R1A,R2F,R3D),(ZB,R1A,R2F,R3E),
(ZB,R1A,R2F,R3F),(ZB,R1A,R2F,R3G),(ZB,R1A,R2F,R3H),
(ZB,R1A,R2F,R3I),(ZB,R1A,R2F,R3J),(ZB,R1A,R2F,R3K),
(ZB,R1A,R2F,R3L),(ZB,R1A,R2F,R3M),(ZB,R1A,R2F,R3N),
(ZB,R1A,R2F,R3O),(ZB,R1A,R2F,R3P),(ZB,R1A,R2F,R3Q),
(ZB,R1A,R2F,R3R),(ZB,R1A,R2G,R3A),(ZB,R1A,R2G,R3B),
(ZB,R1A,R2G,R3C),(ZB,R1A,R2G,R3D),(ZB,R1A,R2G,R3E),
(ZB,R1A,R2G,R3F),(ZB,R1A,R2G,R3G),(ZB,R1A,R2G,R3H),
(ZB,R1A,R2G,R3I),(ZB,R1A,R2G,R3J),(ZB,R1A,R2G,R3K),
(ZB,R1A,R2G,R3L),(ZB,R1A,R2G,R3M),(ZB,R1A,R2G,R3N),
(ZB,R1A,R2G,R3O),(ZB,R1A,R2G,R3P),(ZB,R1A,R2G,R3Q),
(ZB,R1A,R2G,R3R),(ZB,R1A,R2H,R3A),(ZB,R1A,R2H,R3B),
(ZB,R1A,R2H,R3C),(ZB,R1A,R2H,R3D),(ZB,R1A,R2H,R3E),
(ZB,R1A,R2H,R3F),(ZB,R1A,R2H,R3G),(ZB,R1A,R2H,R3H),
(ZB,R1A,R2H,R3I),(ZB,R1A,R2H,R3J),(ZB,R1A,R2H,R3K),
(ZB,R1A,R2H,R3L),(ZB,R1A,R2H,R3M),(ZB,R1A,R2H,R3N),
(ZB,R1A,R2H,R3O),(ZB,R1A,R2H,R3P),(ZB,R1A,R2H,R3Q),
(ZB,R1A,R2H,R3R),(ZB,R1A,R2I,R3A),(ZB,R1A,R2I,R3B),
(ZB,R1A,R2I,R3C),(ZB,R1A,R2I,R3D),(ZB,R1A,R2I,R3E),
(ZB,R1A,R2I,R3F),(ZB,R1A,R2I,R3G),(ZB,R1A,R2I,R3H),
(ZB,R1A,R2I,R3I),(ZB,R1A,R2I,R3J),(ZB,R1A,R2I,R3K),
(ZB,R1A,R2I,R3L),(ZB,R1A,R2I,R3M),(ZB,R1A,R2I,R3N),
(ZB,R1A,R2I,R3O),(ZB,R1A,R2I,R3P),(ZB,R1A,R2I,R3Q),
(ZB,R1A,R2I,R3R),(ZB,R1A,R2J,R3A),(ZB,R1A,R2J,R3B),
(ZB,R1A,R2J,R3C),(ZB,R1A,R2J,R3D),(ZB,R1A,R2J,R3E),
(ZB,R1A,R2J,R3F),(ZB,R1A,R2J,R3G),(ZB,R1A,R2J,R3H),
(ZB,R1A,R2J,R3I),(ZB,R1A,R2J,R3J),(ZB,R1A,R2J,R3K),
(ZB,R1A,R2J,R3L),(ZB,R1A,R2J,R3M),(ZB,R1A,R2J,R3N),
(ZB,R1A,R2J,R3O),(ZB,R1A,R2J,R3P),(ZB,R1A,R2J,R3Q),
(ZB,R1A,R2J,R3R),(ZB,R1A,R2K,R3A),(ZB,R1A,R2K,R3B),
(ZB,R1A,R2K,R3C),(ZB,R1A,R2K,R3D),(ZB,R1A,R2K,R3E),
(ZB,R1A,R2K,R3F),(ZB,R1A,R2K,R3G),(ZB,R1A,R2K,R3H),
(ZB,R1A,R2K,R3I),(ZB,R1A,R2K,R3J),(ZB,R1A,R2K,R3K),
(ZB,R1A,R2K,R3L),(ZB,R1A,R2K,R3M),(ZB,R1A,R2K,R3N),
(ZB,R1A,R2K,R3O),(ZB,R1A,R2K,R3P),(ZB,R1A,R2K,R3Q),
(ZB,R1A,R2K,R3R),(ZB,R1A,R2L,R3A),(ZB,R1A,R2L,R3B),
(ZB,R1A,R2L,R3C),(ZB,R1A,R2L,R3D),(ZB,R1A,R2L,R3E),
(ZB,R1A,R2L,R3F),(ZB,R1A,R2L,R3G),(ZB,R1A,R2L,R3H),
(ZB,R1A,R2L,R3I),(ZB,R1A,R2L,R3J),(ZB,R1A,R2L,R3K),
(ZB,R1A,R2L,R3L),(ZB,R1A,R2L,R3M),(ZB,R1A,R2L,R3N),
(ZB,R1A,R2L,R3O),(ZB,R1A,R2L,R3P),(ZB,R1A,R2L,R3Q),
(ZB,R1A,R2L,R3R),(ZB,R1A,R2M,R3A),(ZB,R1A,R2M,R3B),
(ZB,R1A,R2M,R3C),(ZB,R1A,R2M,R3D),(ZB,R1A,R2M,R3E),
(ZB,R1A,R2M,R3F),(ZB,R1A,R2M,R3G),(ZB,R1A,R2M,R3H),
(ZB,R1A,R2M,R3I),(ZB,R1A,R2M,R3J),(ZB,R1A,R2M,R3K),
(ZB,R1A,R2M,R3L),(ZB,R1A,R2M,R3M),(ZB,R1A,R2M,R3N),
(ZB,R1A,R2M,R3O),(ZB,R1A,R2M,R3P),(ZB,R1A,R2M,R3Q),
(ZB,R1A,R2M,R3R),(ZB,R1A,R2N,R3A),(ZB,R1A,R2N,R3B),
(ZB,R1A,R2N,R3C),(ZB,R1A,R2N,R3D),(ZB,R1A,R2N,R3E),
(ZB,R1A,R2N,R3F),(ZB,R1A,R2N,R3G),(ZB,R1A,R2N,R3H),
(ZB,R1A,R2N,R3I),(ZB,R1A,R2N,R3J),(ZB,R1A,R2N,R3K),
(ZB,R1A,R2N,R3L),(ZB,R1A,R2N,R3M),(ZB,R1A,R2N,R3N),
(ZB,R1A,R2N,R3O),(ZB,R1A,R2N,R3P),(ZB,R1A,R2N,R3Q),
(ZB,R1A,R2N,R3R),(ZB,R1B,R2A,R3A),(ZB,R1B,R2A,R3B),
(ZB,R1B,R2A,R3C),(ZB,R1B,R2A,R3D),(ZB,R1B,R2A,R3E),
(ZB,R1B,R2A,R3F),(ZB,R1B,R2A,R3G),(ZB,R1B,R2A,R3H),
(ZB,R1B,R2A,R3I),(ZB,R1B,R2A,R3J),(ZB,R1B,R2A,R3K),
(ZB,R1B,R2A,R3L),(ZB,R1B,R2A,R3M),(ZB,R1B,R2A,R3N),
(ZB,R1B,R2A,R3O),(ZB,R1B,R2A,R3P),(ZB,R1B,R2A,R3Q),
(ZB,R1B,R2A,R3R),(ZB,R1B,R2B,R3A),(ZB,R1B,R2B,R3B),
(ZB,R1B,R2B,R3C),(ZB,R1B,R2B,R3D),(ZB,R1B,R2B,R3E),
(ZB,R1B,R2B,R3F),(ZB,R1B,R2B,R3G),(ZB,R1B,R2B,R3H),
(ZB,R1B,R2B,R3I),(ZB,R1B,R2B,R3J),(ZB,R1B,R2B,R3K),
(ZB,R1B,R2B,R3L),(ZB,R1B,R2B,R3M),(ZB,R1B,R2B,R3N),
(ZB,R1B,R2B,R3O),(ZB,R1B,R2B,R3P),(ZB,R1B,R2B,R3Q),
(ZB,R1B,R2B,R3R),(ZB,R1B,R2C,R3A),(ZB,R1B,R2C,R3B),
(ZB,R1B,R2C,R3C),(ZB,R1B,R2C,R3D),(ZB,R1B,R2C,R3E),
(ZB,R1B,R2C,R3F),(ZB,R1B,R2C,R3G),(ZB,R1B,R2C,R3H),
(ZB,R1B,R2C,R3I),(ZB,R1B,R2C,R3J),(ZB,R1B,R2C,R3K),
(ZB,R1B,R2C,R3L),(ZB,R1B,R2C,R3M),(ZB,R1B,R2C,R3N),
(ZB,R1B,R2C,R3O),(ZB,R1B,R2C,R3P),(ZB,R1B,R2C,R3Q),
(ZB,R1B,R2C,R3R),(ZB,R1B,R2D,R3A),(ZB,R1B,R2D,R3B),
(ZB,R1B,R2D,R3C),(ZB,R1B,R2D,R3D),(ZB,R1B,R2D,R3E),
(ZB,R1B,R2D,R3F),(ZB,R1B,R2D,R3G),(ZB,R1B,R2D,R3H),
(ZB,R1B,R2D,R3I),(ZB,R1B,R2D,R3J),(ZB,R1B,R2D,R3K),
(ZB,R1B,R2D,R3L),(ZB,R1B,R2D,R3M),(ZB,R1B,R2D,R3N),
(ZB,R1B,R2D,R3O),(ZB,R1B,R2D,R3P),(ZB,R1B,R2D,R3Q),
(ZB,R1B,R2D,R3R),(ZB,R1B,R2E,R3A),(ZB,R1B,R2E,R3B),
(ZB,R1B,R2E,R3C),(ZB,R1B,R2E,R3D),(ZB,R1B,R2E,R3E),
(ZB,R1B,R2E,R3F),(ZB,R1B,R2E,R3G),(ZB,R1B,R2E,R3H),
(ZB,R1B,R2E,R3I),(ZB,R1B,R2E,R3J),(ZB,R1B,R2E,R3K),
(ZB,R1B,R2E,R3L),(ZB,R1B,R2E,R3M),(ZB,R1B,R2E,R3N),
(ZB,R1B,R2E,R3O),(ZB,R1B,R2E,R3P),(ZB,R1B,R2E,R3Q),
(ZB,R1B,R2E,R3R),(ZB,R1B,R2F,R3A),(ZB,R1B,R2F,R3B),
(ZB,R1B,R2F,R3C),(ZB,R1B,R2F,R3D),(ZB,R1B,R2F,R3E),
(ZB,R1B,R2F,R3F),(ZB,R1B,R2F,R3G),(ZB,R1B,R2F,R3H),
(ZB,R1B,R2F,R3I),(ZB,R1B,R2F,R3J),(ZB,R1B,R2F,R3K),
(ZB,R1B,R2F,R3L),(ZB,R1B,R2F,R3M),(ZB,R1B,R2F,R3N),
(ZB,R1B,R2F,R3O),(ZB,R1B,R2F,R3P),(ZB,R1B,R2F,R3Q),
(ZB,R1B,R2F,R3R),(ZB,R1B,R2G,R3A),(ZB,R1B,R2G,R3B),
(ZB,R1B,R2G,R3C),(ZB,R1B,R2G,R3D),(ZB,R1B,R2G,R3E),
(ZB,R1B,R2G,R3F),(ZB,R1B,R2G,R3G),(ZB,R1B,R2G,R3H),
(ZB,R1B,R2G,R3I),(ZB,R1B,R2G,R3J),(ZB,R1B,R2G,R3K),
(ZB,R1B,R2G,R3L),(ZB,R1B,R2G,R3M),(ZB,R1B,R2G,R3N),
(ZB,R1B,R2G,R3O),(ZB,R1B,R2G,R3P),(ZB,R1B,R2G,R3Q),
(ZB,R1B,R2G,R3R),(ZB,R1B,R2H,R3A),(ZB,R1B,R2H,R3B),
(ZB,R1B,R2H,R3C),(ZB,R1B,R2H,R3D),(ZB,R1B,R2H,R3E),
(ZB,R1B,R2H,R3F),(ZB,R1B,R2H,R3G),(ZB,R1B,R2H,R3H),
(ZB,R1B,R2H,R3I),(ZB,R1B,R2H,R3J),(ZB,R1B,R2H,R3K),
(ZB,R1B,R2H,R3L),(ZB,R1B,R2H,R3M),(ZB,R1B,R2H,R3N),
(ZB,R1B,R2H,R3O),(ZB,R1B,R2H,R3P),(ZB,R1B,R2H,R3Q),
(ZB,R1B,R2H,R3R),(ZB,R1B,R2I,R3A),(ZB,R1B,R2I,R3B),
(ZB,R1B,R2I,R3C),(ZB,R1B,R2I,R3D),(ZB,R1B,R2I,R3E),
(ZB,R1B,R2I,R3F),(ZB,R1B,R2I,R3G),(ZB,R1B,R2I,R3H),
(ZB,R1B,R2I,R3I),(ZB,R1B,R2I,R3J),(ZB,R1B,R2I,R3K),
(ZB,R1B,R2I,R3L),(ZB,R1B,R2I,R3M),(ZB,R1B,R2I,R3N),
(ZB,R1B,R2I,R3O),(ZB,R1B,R2I,R3P),(ZB,R1B,R2I,R3Q),
(ZB,R1B,R2I,R3R),(ZB,R1B,R2J,R3A),(ZB,R1B,R2J,R3B),
(ZB,R1B,R2J,R3C),(ZB,R1B,R2J,R3D),(ZB,R1B,R2J,R3E),
(ZB,R1B,R2J,R3F),(ZB,R1B,R2J,R3G),(ZB,R1B,R2J,R3H),
(ZB,R1B,R2J,R3I),(ZB,R1B,R2J,R3J),(ZB,R1B,R2J,R3K),
(ZB,R1B,R2J,R3L),(ZB,R1B,R2J,R3M),(ZB,R1B,R2J,R3N),
(ZB,R1B,R2J,R3O),(ZB,R1B,R2J,R3P),(ZB,R1B,R2J,R3Q),
(ZB,R1B,R2J,R3R),(ZB,R1B,R2K,R3A),(ZB,R1B,R2K,R3B),
(ZB,R1B,R2K,R3C),(ZB,R1B,R2K,R3D),(ZB,R1B,R2K,R3E),
(ZB,R1B,R2K,R3F),(ZB,R1B,R2K,R3G),(ZB,R1B,R2K,R3H),
(ZB,R1B,R2K,R3I),(ZB,R1B,R2K,R3J),(ZB,R1B,R2K,R3K),
(ZB,R1B,R2K,R3L),(ZB,R1B,R2K,R3M),(ZB,R1B,R2K,R3N),
(ZB,R1B,R2K,R3O),(ZB,R1B,R2K,R3P),(ZB,R1B,R2K,R3Q),
(ZB,R1B,R2K,R3R),(ZB,R1B,R2L,R3A),(ZB,R1B,R2L,R3B),
(ZB,R1B,R2L,R3C),(ZB,R1B,R2L,R3D),(ZB,R1B,R2L,R3E),
(ZB,R1B,R2L,R3F),(ZB,R1B,R2L,R3G),(ZB,R1B,R2L,R3H),
(ZB,R1B,R2L,R3I),(ZB,R1B,R2L,R3J),(ZB,R1B,R2L,R3K),
(ZB,R1B,R2L,R3L),(ZB,R1B,R2L,R3M),(ZB,R1B,R2L,R3N),
(ZB,R1B,R2L,R3O),(ZB,R1B,R2L,R3P),(ZB,R1B,R2L,R3Q),
(ZB,R1B,R2L,R3R),(ZB,R1B,R2M,R3A),(ZB,R1B,R2M,R3B),
(ZB,R1B,R2M,R3C),(ZB,R1B,R2M,R3D),(ZB,R1B,R2M,R3E),
(ZB,R1B,R2M,R3F),(ZB,R1B,R2M,R3G),(ZB,R1B,R2M,R3H),
(ZB,R1B,R2M,R3I),(ZB,R1B,R2M,R3J),(ZB,R1B,R2M,R3K),
(ZB,R1B,R2M,R3L),(ZB,R1B,R2M,R3M),(ZB,R1B,R2M,R3N),
(ZB,R1B,R2M,R3O),(ZB,R1B,R2M,R3P),(ZB,R1B,R2M,R3Q),
(ZB,R1B,R2M,R3R),(ZB,R1B,R2N,R3A),(ZB,R1B,R2N,R3B),
(ZB,R1B,R2N,R3C),(ZB,R1B,R2N,R3D),(ZB,R1B,R2N,R3E),
(ZB,R1B,R2N,R3F),(ZB,R1B,R2N,R3G),(ZB,R1B,R2N,R3H),
(ZB,R1B,R2N,R3I),(ZB,R1B,R2N,R3J),(ZB,R1B,R2N,R3K),
(ZB,R1B,R2N,R3L),(ZB,R1B,R2N,R3M),(ZB,R1B,R2N,R3N),
(ZB,R1B,R2N,R3O),(ZB,R1B,R2N,R3P),(ZB,R1B,R2N,R3Q),
(ZB,R1B,R2N,R3R),(ZB,R1C,R2A,R3A),(ZB,R1C,R2A,R3B),
(ZB,R1C,R2A,R3C),(ZB,R1C,R2A,R3D),(ZB,R1C,R2A,R3E),
(ZB,R1C,R2A,R3F),(ZB,R1C,R2A,R3G),(ZB,R1C,R2A,R3H),
(ZB,R1C,R2A,R3I),(ZB,R1C,R2A,R3J),(ZB,R1C,R2A,R3K),
(ZB,R1C,R2A,R3L),(ZB,R1C,R2A,R3M),(ZB,R1C,R2A,R3N),
(ZB,R1C,R2A,R3O),(ZB,R1C,R2A,R3P),(ZB,R1C,R2A,R3Q),
(ZB,R1C,R2A,R3R),(ZB,R1C,R2B,R3A),(ZB,R1C,R2B,R3B),
(ZB,R1C,R2B,R3C),(ZB,R1C,R2B,R3D),(ZB,R1C,R2B,R3E),
(ZB,R1C,R2B,R3F),(ZB,R1C,R2B,R3G),(ZB,R1C,R2B,R3H),
(ZB,R1C,R2B,R3I),(ZB,R1C,R2B,R3J),(ZB,R1C,R2B,R3K),
(ZB,R1C,R2B,R3L),(ZB,R1C,R2B,R3M),(ZB,R1C,R2B,R3N),
(ZB,R1C,R2B,R3O),(ZB,R1C,R2B,R3P),(ZB,R1C,R2B,R3Q),
(ZB,R1C,R2B,R3R),(ZB,R1C,R2C,R3A),(ZB,R1C,R2C,R3B),
(ZB,R1C,R2C,R3C),(ZB,R1C,R2C,R3D),(ZB,R1C,R2C,R3E),
(ZB,R1C,R2C,R3F),(ZB,R1C,R2C,R3G),(ZB,R1C,R2C,R3H),
(ZB,R1C,R2C,R3I),(ZB,R1C,R2C,R3J),(ZB,R1C,R2C,R3K),
(ZB,R1C,R2C,R3L),(ZB,R1C,R2C,R3M),(ZB,R1C,R2C,R3N),
(ZB,R1C,R2C,R3O),(ZB,R1C,R2C,R3P),(ZB,R1C,R2C,R3Q),
(ZB,R1C,R2C,R3R),(ZB,R1C,R2D,R3A),(ZB,R1C,R2D,R3B),
(ZB,R1C,R2D,R3C),(ZB,R1C,R2D,R3D),(ZB,R1C,R2D,R3E),
(ZB,R1C,R2D,R3F),(ZB,R1C,R2D,R3G),(ZB,R1C,R2D,R3H),
(ZB,R1C,R2D,R3I),(ZB,R1C,R2D,R3J),(ZB,R1C,R2D,R3K),
(ZB,R1C,R2D,R3L),(ZB,R1C,R2D,R3M),(ZB,R1C,R2D,R3N),
(ZB,R1C,R2D,R3O),(ZB,R1C,R2D,R3P),(ZB,R1C,R2D,R3Q),
(ZB,R1C,R2D,R3R),(ZB,R1C,R2E,R3A),(ZB,R1C,R2E,R3B),
(ZB,R1C,R2E,R3C),(ZB,R1C,R2E,R3D),(ZB,R1C,R2E,R3E),
(ZB,R1C,R2E,R3F),(ZB,R1C,R2E,R3G),(ZB,R1C,R2E,R3H),
(ZB,R1C,R2E,R3I),(ZB,R1C,R2E,R3J),(ZB,R1C,R2E,R3K),
(ZB,R1C,R2E,R3L),(ZB,R1C,R2E,R3M),(ZB,R1C,R2E,R3N),
(ZB,R1C,R2E,R3O),(ZB,R1C,R2E,R3P),(ZB,R1C,R2E,R3Q),
(ZB,R1C,R2E,R3R),(ZB,R1C,R2F,R3A),(ZB,R1C,R2F,R3B),
(ZB,R1C,R2F,R3C),(ZB,R1C,R2F,R3D),(ZB,R1C,R2F,R3E),
(ZB,R1C,R2F,R3F),(ZB,R1C,R2F,R3G),(ZB,R1C,R2F,R3H),
(ZB,R1C,R2F,R3I),(ZB,R1C,R2F,R3J),(ZB,R1C,R2F,R3K),
(ZB,R1C,R2F,R3L),(ZB,R1C,R2F,R3M),(ZB,R1C,R2F,R3N),
(ZB,R1C,R2F,R3O),(ZB,R1C,R2F,R3P),(ZB,R1C,R2F,R3Q),
(ZB,R1C,R2F,R3R),(ZB,R1C,R2G,R3A),(ZB,R1C,R2G,R3B),
(ZB,R1C,R2G,R3C),(ZB,R1C,R2G,R3D),(ZB,R1C,R2G,R3E),
(ZB,R1C,R2G,R3F),(ZB,R1C,R2G,R3G),(ZB,R1C,R2G,R3H),
(ZB,R1C,R2G,R3I),(ZB,R1C,R2G,R3J),(ZB,R1C,R2G,R3K),
(ZB,R1C,R2G,R3L),(ZB,R1C,R2G,R3M),(ZB,R1C,R2G,R3N),
(ZB,R1C,R2G,R3O),(ZB,R1C,R2G,R3P),(ZB,R1C,R2G,R3Q),
(ZB,R1C,R2G,R3R),(ZB,R1C,R2H,R3A),(ZB,R1C,R2H,R3B),
(ZB,R1C,R2H,R3C),(ZB,R1C,R2H,R3D),(ZB,R1C,R2H,R3E),
(ZB,R1C,R2H,R3F),(ZB,R1C,R2H,R3G),(ZB,R1C,R2H,R3H),
(ZB,R1C,R2H,R3I),(ZB,R1C,R2H,R3J),(ZB,R1C,R2H,R3K),
(ZB,R1C,R2H,R3L),(ZB,R1C,R2H,R3M),(ZB,R1C,R2H,R3N),
(ZB,R1C,R2H,R3O),(ZB,R1C,R2H,R3P),(ZB,R1C,R2H,R3Q),
(ZB,R1C,R2H,R3R),(ZB,R1C,R2I,R3A),(ZB,R1C,R2I,R3B),
(ZB,R1C,R2I,R3C),(ZB,R1C,R2I,R3D),(ZB,R1C,R2I,R3E),
(ZB,R1C,R2I,R3F),(ZB,R1C,R2I,R3G),(ZB,R1C,R2I,R3H),
(ZB,R1C,R2I,R3I),(ZB,R1C,R2I,R3J),(ZB,R1C,R2I,R3K),
(ZB,R1C,R2I,R3L),(ZB,R1C,R2I,R3M),(ZB,R1C,R2I,R3N),
(ZB,R1C,R2I,R3O),(ZB,R1C,R2I,R3P),(ZB,R1C,R2I,R3Q),
(ZB,R1C,R2I,R3R),(ZB,R1C,R2J,R3A),(ZB,R1C,R2J,R3B),
(ZB,R1C,R2J,R3C),(ZB,R1C,R2J,R3D),(ZB,R1C,R2J,R3E),
(ZB,R1C,R2J,R3F),(ZB,R1C,R2J,R3G),(ZB,R1C,R2J,R3H),
(ZB,R1C,R2J,R3I),(ZB,R1C,R2J,R3J),(ZB,R1C,R2J,R3K),
(ZB,R1C,R2J,R3L),(ZB,R1C,R2J,R3M),(ZB,R1C,R2J,R3N),
(ZB,R1C,R2J,R3O),(ZB,R1C,R2J,R3P),(ZB,R1C,R2J,R3Q),
(ZB,R1C,R2J,R3R),(ZB,R1C,R2K,R3A),(ZB,R1C,R2K,R3B),
(ZB,R1C,R2K,R3C),(ZB,R1C,R2K,R3D),(ZB,R1C,R2K,R3E),
(ZB,R1C,R2K,R3F),(ZB,R1C,R2K,R3G),(ZB,R1C,R2K,R3H),
(ZB,R1C,R2K,R3I),(ZB,R1C,R2K,R3J),(ZB,R1C,R2K,R3K),
(ZB,R1C,R2K,R3L),(ZB,R1C,R2K,R3M),(ZB,R1C,R2K,R3N),
(ZB,R1C,R2K,R3O),(ZB,R1C,R2K,R3P),(ZB,R1C,R2K,R3Q),
(ZB,R1C,R2K,R3R),(ZB,R1C,R2L,R3A),(ZB,R1C,R2L,R3B),
(ZB,R1C,R2L,R3C),(ZB,R1C,R2L,R3D),(ZB,R1C,R2L,R3E),
(ZB,R1C,R2L,R3F),(ZB,R1C,R2L,R3G),(ZB,R1C,R2L,R3H),
(ZB,R1C,R2L,R3I),(ZB,R1C,R2L,R3J),(ZB,R1C,R2L,R3K),
(ZB,R1C,R2L,R3L),(ZB,R1C,R2L,R3M),(ZB,R1C,R2L,R3N),
(ZB,R1C,R2L,R3O),(ZB,R1C,R2L,R3P),(ZB,R1C,R2L,R3Q),
(ZB,R1C,R2L,R3R),(ZB,R1C,R2M,R3A),(ZB,R1C,R2M,R3B),
(ZB,R1C,R2M,R3C),(ZB,R1C,R2M,R3D),(ZB,R1C,R2M,R3E),
(ZB,R1C,R2M,R3F),(ZB,R1C,R2M,R3G),(ZB,R1C,R2M,R3H),
(ZB,R1C,R2M,R3I),(ZB,R1C,R2M,R3J),(ZB,R1C,R2M,R3K),
(ZB,R1C,R2M,R3L),(ZB,R1C,R2M,R3M),(ZB,R1C,R2M,R3N),
(ZB,R1C,R2M,R3O),(ZB,R1C,R2M,R3P),(ZB,R1C,R2M,R3Q),
(ZB,R1C,R2M,R3R),(ZB,R1C,R2N,R3A),(ZB,R1C,R2N,R3B),
(ZB,R1C,R2N,R3C),(ZB,R1C,R2N,R3D),(ZB,R1C,R2N,R3E),
(ZB,R1C,R2N,R3F),(ZB,R1C,R2N,R3G),(ZB,R1C,R2N,R3H),
(ZB,R1C,R2N,R3I),(ZB,R1C,R2N,R3J),(ZB,R1C,R2N,R3K),
(ZB,R1C,R2N,R3L),(ZB,R1C,R2N,R3M),(ZB,R1C,R2N,R3N),
(ZB,R1C,R2N,R3O),(ZB,R1C,R2N,R3P),(ZB,R1C,R2N,R3Q),
(ZB,R1C,R2N,R3R),(ZB,R1D,R2A,R3A),(ZB,R1D,R2A,R3B),
(ZB,R1D,R2A,R3C),(ZB,R1D,R2A,R3D),(ZB,R1D,R2A,R3E),
(ZB,R1D,R2A,R3F),(ZB,R1D,R2A,R3G),(ZB,R1D,R2A,R3H),
(ZB,R1D,R2A,R3I),(ZB,R1D,R2A,R3J),(ZB,R1D,R2A,R3K),
(ZB,R1D,R2A,R3L),(ZB,R1D,R2A,R3M),(ZB,R1D,R2A,R3N),
(ZB,R1D,R2A,R3O),(ZB,R1D,R2A,R3P),(ZB,R1D,R2A,R3Q),
(ZB,R1D,R2A,R3R),(ZB,R1D,R2B,R3A),(ZB,R1D,R2B,R3B),
(ZB,R1D,R2B,R3C),(ZB,R1D,R2B,R3D),(ZB,R1D,R2B,R3E),
(ZB,R1D,R2B,R3F),(ZB,R1D,R2B,R3G),(ZB,R1D,R2B,R3H),
(ZB,R1D,R2B,R3I),(ZB,R1D,R2B,R3J),(ZB,R1D,R2B,R3K),
(ZB,R1D,R2B,R3L),(ZB,R1D,R2B,R3M),(ZB,R1D,R2B,R3N),
(ZB,R1D,R2B,R3O),(ZB,R1D,R2B,R3P),(ZB,R1D,R2B,R3Q),
(ZB,R1D,R2B,R3R),(ZB,R1D,R2C,R3A),(ZB,R1D,R2C,R3B),
(ZB,R1D,R2C,R3C),(ZB,R1D,R2C,R3D),(ZB,R1D,R2C,R3E),
(ZB,R1D,R2C,R3F),(ZB,R1D,R2C,R3G),(ZB,R1D,R2C,R3H),
(ZB,R1D,R2C,R3I),(ZB,R1D,R2C,R3J),(ZB,R1D,R2C,R3K),
(ZB,R1D,R2C,R3L),(ZB,R1D,R2C,R3M),(ZB,R1D,R2C,R3N),
(ZB,R1D,R2C,R3O),(ZB,R1D,R2C,R3P),(ZB,R1D,R2C,R3Q),
(ZB,R1D,R2C,R3R),(ZB,R1D,R2D,R3A),(ZB,R1D,R2D,R3B),
(ZB,R1D,R2D,R3C),(ZB,R1D,R2D,R3D),(ZB,R1D,R2D,R3E),
(ZB,R1D,R2D,R3F),(ZB,R1D,R2D,R3G),(ZB,R1D,R2D,R3H),
(ZB,R1D,R2D,R3I),(ZB,R1D,R2D,R3J),(ZB,R1D,R2D,R3K),
(ZB,R1D,R2D,R3L),(ZB,R1D,R2D,R3M),(ZB,R1D,R2D,R3N),
(ZB,R1D,R2D,R3O),(ZB,R1D,R2D,R3P),(ZB,R1D,R2D,R3Q),
(ZB,R1D,R2D,R3R),(ZB,R1D,R2E,R3A),(ZB,R1D,R2E,R3B),
(ZB,R1D,R2E,R3C),(ZB,R1D,R2E,R3D),(ZB,R1D,R2E,R3E),
(ZB,R1D,R2E,R3F),(ZB,R1D,R2E,R3G),(ZB,R1D,R2E,R3H),
(ZB,R1D,R2E,R3I),(ZB,R1D,R2E,R3J),(ZB,R1D,R2E,R3K),
(ZB,R1D,R2E,R3L),(ZB,R1D,R2E,R3M),(ZB,R1D,R2E,R3N),
(ZB,R1D,R2E,R3O),(ZB,R1D,R2E,R3P),(ZB,R1D,R2E,R3Q),
(ZB,R1D,R2E,R3R),(ZB,R1D,R2F,R3A),(ZB,R1D,R2F,R3B),
(ZB,R1D,R2F,R3C),(ZB,R1D,R2F,R3D),(ZB,R1D,R2F,R3E),
(ZB,R1D,R2F,R3F),(ZB,R1D,R2F,R3G),(ZB,R1D,R2F,R3H),
(ZB,R1D,R2F,R3I),(ZB,R1D,R2F,R3J),(ZB,R1D,R2F,R3K),
(ZB,R1D,R2F,R3L),(ZB,R1D,R2F,R3M),(ZB,R1D,R2F,R3N),
(ZB,R1D,R2F,R3O),(ZB,R1D,R2F,R3P),(ZB,R1D,R2F,R3Q),
(ZB,R1D,R2F,R3R),(ZB,R1D,R2G,R3A),(ZB,R1D,R2G,R3B),
(ZB,R1D,R2G,R3C),(ZB,R1D,R2G,R3D),(ZB,R1D,R2G,R3E),
(ZB,R1D,R2G,R3F),(ZB,R1D,R2G,R3G),(ZB,R1D,R2G,R3H),
(ZB,R1D,R2G,R3I),(ZB,R1D,R2G,R3J),(ZB,R1D,R2G,R3K),
(ZB,R1D,R2G,R3L),(ZB,R1D,R2G,R3M),(ZB,R1D,R2G,R3N),
(ZB,R1D,R2G,R3O),(ZB,R1D,R2G,R3P),(ZB,R1D,R2G,R3Q),
(ZB,R1D,R2G,R3R),(ZB,R1D,R2H,R3A),(ZB,R1D,R2H,R3B),
(ZB,R1D,R2H,R3C),(ZB,R1D,R2H,R3D),(ZB,R1D,R2H,R3E),
(ZB,R1D,R2H,R3F),(ZB,R1D,R2H,R3G),(ZB,R1D,R2H,R3H),
(ZB,R1D,R2H,R3I),(ZB,R1D,R2H,R3J),(ZB,R1D,R2H,R3K),
(ZB,R1D,R2H,R3L),(ZB,R1D,R2H,R3M),(ZB,R1D,R2H,R3N),
(ZB,R1D,R2H,R3O),(ZB,R1D,R2H,R3P),(ZB,R1D,R2H,R3Q),
(ZB,R1D,R2H,R3R),(ZB,R1D,R2I,R3A),(ZB,R1D,R2I,R3B),
(ZB,R1D,R2I,R3C),(ZB,R1D,R2I,R3D),(ZB,R1D,R2I,R3E),
(ZB,R1D,R2I,R3F),(ZB,R1D,R2I,R3G),(ZB,R1D,R2I,R3H),
(ZB,R1D,R2I,R3I),(ZB,R1D,R2I,R3J),(ZB,R1D,R2I,R3K),
(ZB,R1D,R2I,R3L),(ZB,R1D,R2I,R3M),(ZB,R1D,R2I,R3N),
(ZB,R1D,R2I,R3O),(ZB,R1D,R2I,R3P),(ZB,R1D,R2I,R3Q),
(ZB,R1D,R2I,R3R),(ZB,R1D,R2J,R3A),(ZB,R1D,R2J,R3B),
(ZB,R1D,R2J,R3C),(ZB,R1D,R2J,R3D),(ZB,R1D,R2J,R3E),
(ZB,R1D,R2J,R3F),(ZB,R1D,R2J,R3G),(ZB,R1D,R2J,R3H),
(ZB,R1D,R2J,R3I),(ZB,R1D,R2J,R3J),(ZB,R1D,R2J,R3K),
(ZB,R1D,R2J,R3L),(ZB,R1D,R2J,R3M),(ZB,R1D,R2J,R3N),
(ZB,R1D,R2J,R3O),(ZB,R1D,R2J,R3P),(ZB,R1D,R2J,R3Q),
(ZB,R1D,R2J,R3R),(ZB,R1D,R2K,R3A),(ZB,R1D,R2K,R3B),
(ZB,R1D,R2K,R3C),(ZB,R1D,R2K,R3D),(ZB,R1D,R2K,R3E),
(ZB,R1D,R2K,R3F),(ZB,R1D,R2K,R3G),(ZB,R1D,R2K,R3H),
(ZB,R1D,R2K,R3I),(ZB,R1D,R2K,R3J),(ZB,R1D,R2K,R3K),
(ZB,R1D,R2K,R3L),(ZB,R1D,R2K,R3M),(ZB,R1D,R2K,R3N),
(ZB,R1D,R2K,R3O),(ZB,R1D,R2K,R3P),(ZB,R1D,R2K,R3Q),
(ZB,R1D,R2K,R3R),(ZB,R1D,R2L,R3A),(ZB,R1D,R2L,R3B),
(ZB,R1D,R2L,R3C),(ZB,R1D,R2L,R3D),(ZB,R1D,R2L,R3E),
(ZB,R1D,R2L,R3F),(ZB,R1D,R2L,R3G),(ZB,R1D,R2L,R3H),
(ZB,R1D,R2L,R3I),(ZB,R1D,R2L,R3J),(ZB,R1D,R2L,R3K),
(ZB,R1D,R2L,R3L),(ZB,R1D,R2L,R3M),(ZB,R1D,R2L,R3N),
(ZB,R1D,R2L,R3O),(ZB,R1D,R2L,R3P),(ZB,R1D,R2L,R3Q),
(ZB,R1D,R2L,R3R),(ZB,R1D,R2M,R3A),(ZB,R1D,R2M,R3B),
(ZB,R1D,R2M,R3C),(ZB,R1D,R2M,R3D),(ZB,R1D,R2M,R3E),
(ZB,R1D,R2M,R3F),(ZB,R1D,R2M,R3G),(ZB,R1D,R2M,R3H),
(ZB,R1D,R2M,R3I),(ZB,R1D,R2M,R3J),(ZB,R1D,R2M,R3K),
(ZB,R1D,R2M,R3L),(ZB,R1D,R2M,R3M),(ZB,R1D,R2M,R3N),
(ZB,R1D,R2M,R3O),(ZB,R1D,R2M,R3P),(ZB,R1D,R2M,R3Q),
(ZB,R1D,R2M,R3R),(ZB,R1D,R2N,R3A),(ZB,R1D,R2N,R3B),
(ZB,R1D,R2N,R3C),(ZB,R1D,R2N,R3D),(ZB,R1D,R2N,R3E),
(ZB,R1D,R2N,R3F),(ZB,R1D,R2N,R3G),(ZB,R1D,R2N,R3H),
(ZB,R1D,R2N,R3I),(ZB,R1D,R2N,R3J),(ZB,R1D,R2N,R3K),
(ZB,R1D,R2N,R3L),(ZB,R1D,R2N,R3M),(ZB,R1D,R2N,R3N),
(ZB,R1D,R2N,R3O),(ZB,R1D,R2N,R3P),(ZB,R1D,R2N,R3Q),
(ZB,R1D,R2N,R3R),(ZB,R1E,R2A,R3A),(ZB,R1E,R2A,R3B),
(ZB,R1E,R2A,R3C),(ZB,R1E,R2A,R3D),(ZB,R1E,R2A,R3E),
(ZB,R1E,R2A,R3F),(ZB,R1E,R2A,R3G),(ZB,R1E,R2A,R3H),
(ZB,R1E,R2A,R3I),(ZB,R1E,R2A,R3J),(ZB,R1E,R2A,R3K),
(ZB,R1E,R2A,R3L),(ZB,R1E,R2A,R3M),(ZB,R1E,R2A,R3N),
(ZB,R1E,R2A,R3O),(ZB,R1E,R2A,R3P),(ZB,R1E,R2A,R3Q),
(ZB,R1E,R2A,R3R),(ZB,R1E,R2B,R3A),(ZB,R1E,R2B,R3B),
(ZB,R1E,R2B,R3C),(ZB,R1E,R2B,R3D),(ZB,R1E,R2B,R3E),
(ZB,R1E,R2B,R3F),(ZB,R1E,R2B,R3G),(ZB,R1E,R2B,R3H),
(ZB,R1E,R2B,R3I),(ZB,R1E,R2B,R3J),(ZB,R1E,R2B,R3K),
(ZB,R1E,R2B,R3L),(ZB,R1E,R2B,R3M),(ZB,R1E,R2B,R3N),
(ZB,R1E,R2B,R3O),(ZB,R1E,R2B,R3P),(ZB,R1E,R2B,R3Q),
(ZB,R1E,R2B,R3R),(ZB,R1E,R2C,R3A),(ZB,R1E,R2C,R3B),
(ZB,R1E,R2C,R3C),(ZB,R1E,R2C,R3D),(ZB,R1E,R2C,R3E),
(ZB,R1E,R2C,R3F),(ZB,R1E,R2C,R3G),(ZB,R1E,R2C,R3H),
(ZB,R1E,R2C,R3I),(ZB,R1E,R2C,R3J),(ZB,R1E,R2C,R3K),
(ZB,R1E,R2C,R3L),(ZB,R1E,R2C,R3M),(ZB,R1E,R2C,R3N),
(ZB,R1E,R2C,R3O),(ZB,R1E,R2C,R3P),(ZB,R1E,R2C,R3Q),
(ZB,R1E,R2C,R3R),(ZB,R1E,R2D,R3A),(ZB,R1E,R2D,R3B),
(ZB,R1E,R2D,R3C),(ZB,R1E,R2D,R3D),(ZB,R1E,R2D,R3E),
(ZB,R1E,R2D,R3F),(ZB,R1E,R2D,R3G),(ZB,R1E,R2D,R3H),
(ZB,R1E,R2D,R3I),(ZB,R1E,R2D,R3J),(ZB,R1E,R2D,R3K),
(ZB,R1E,R2D,R3L),(ZB,R1E,R2D,R3M),(ZB,R1E,R2D,R3N),
(ZB,R1E,R2D,R3O),(ZB,R1E,R2D,R3P),(ZB,R1E,R2D,R3Q),
(ZB,R1E,R2D,R3R),(ZB,R1E,R2E,R3A),(ZB,R1E,R2E,R3B),
(ZB,R1E,R2E,R3C),(ZB,R1E,R2E,R3D),(ZB,R1E,R2E,R3E),
(ZB,R1E,R2E,R3F),(ZB,R1E,R2E,R3G),(ZB,R1E,R2E,R3H),
(ZB,R1E,R2E,R3I),(ZB,R1E,R2E,R3J),(ZB,R1E,R2E,R3K),
(ZB,R1E,R2E,R3L),(ZB,R1E,R2E,R3M),(ZB,R1E,R2E,R3N),
(ZB,R1E,R2E,R3O),(ZB,R1E,R2E,R3P),(ZB,R1E,R2E,R3Q),
(ZB,R1E,R2E,R3R),(ZB,R1E,R2F,R3A),(ZB,R1E,R2F,R3B),
(ZB,R1E,R2F,R3C),(ZB,R1E,R2F,R3D),(ZB,R1E,R2F,R3E),
(ZB,R1E,R2F,R3F),(ZB,R1E,R2F,R3G),(ZB,R1E,R2F,R3H),
(ZB,R1E,R2F,R3I),(ZB,R1E,R2F,R3J),(ZB,R1E,R2F,R3K),
(ZB,R1E,R2F,R3L),(ZB,R1E,R2F,R3M),(ZB,R1E,R2F,R3N),
(ZB,R1E,R2F,R3O),(ZB,R1E,R2F,R3P),(ZB,R1E,R2F,R3Q),
(ZB,R1E,R2F,R3R),(ZB,R1E,R2G,R3A),(ZB,R1E,R2G,R3B),
(ZB,R1E,R2G,R3C),(ZB,R1E,R2G,R3D),(ZB,R1E,R2G,R3E),
(ZB,R1E,R2G,R3F),(ZB,R1E,R2G,R3G),(ZB,R1E,R2G,R3H),
(ZB,R1E,R2G,R3I),(ZB,R1E,R2G,R3J),(ZB,R1E,R2G,R3K),
(ZB,R1E,R2G,R3L),(ZB,R1E,R2G,R3M),(ZB,R1E,R2G,R3N),
(ZB,R1E,R2G,R3O),(ZB,R1E,R2G,R3P),(ZB,R1E,R2G,R3Q),
(ZB,R1E,R2G,R3R),(ZB,R1E,R2H,R3A),(ZB,R1E,R2H,R3B),
(ZB,R1E,R2H,R3C),(ZB,R1E,R2H,R3D),(ZB,R1E,R2H,R3E),
(ZB,R1E,R2H,R3F),(ZB,R1E,R2H,R3G),(ZB,R1E,R2H,R3H),
(ZB,R1E,R2H,R3I),(ZB,R1E,R2H,R3J),(ZB,R1E,R2H,R3K),
(ZB,R1E,R2H,R3L),(ZB,R1E,R2H,R3M),(ZB,R1E,R2H,R3N),
(ZB,R1E,R2H,R3O),(ZB,R1E,R2H,R3P),(ZB,R1E,R2H,R3Q),
(ZB,R1E,R2H,R3R),(ZB,R1E,R2I,R3A),(ZB,R1E,R2I,R3B),
(ZB,R1E,R2I,R3C),(ZB,R1E,R2I,R3D),(ZB,R1E,R2I,R3E),
(ZB,R1E,R2I,R3F),(ZB,R1E,R2I,R3G),(ZB,R1E,R2I,R3H),
(ZB,R1E,R2I,R3I),(ZB,R1E,R2I,R3J),(ZB,R1E,R2I,R3K),
(ZB,R1E,R2I,R3L),(ZB,R1E,R2I,R3M),(ZB,R1E,R2I,R3N),
(ZB,R1E,R2I,R3O),(ZB,R1E,R2I,R3P),(ZB,R1E,R2I,R3Q),
(ZB,R1E,R2I,R3R),(ZB,R1E,R2J,R3A),(ZB,R1E,R2J,R3B),
(ZB,R1E,R2J,R3C),(ZB,R1E,R2J,R3D),(ZB,R1E,R2J,R3E),
(ZB,R1E,R2J,R3F),(ZB,R1E,R2J,R3G),(ZB,R1E,R2J,R3H),
(ZB,R1E,R2J,R3I),(ZB,R1E,R2J,R3J),(ZB,R1E,R2J,R3K),
(ZB,R1E,R2J,R3L),(ZB,R1E,R2J,R3M),(ZB,R1E,R2J,R3N),
(ZB,R1E,R2J,R3O),(ZB,R1E,R2J,R3P),(ZB,R1E,R2J,R3Q),
(ZB,R1E,R2J,R3R),(ZB,R1E,R2K,R3A),(ZB,R1E,R2K,R3B),
(ZB,R1E,R2K,R3C),(ZB,R1E,R2K,R3D),(ZB,R1E,R2K,R3E),
(ZB,R1E,R2K,R3F),(ZB,R1E,R2K,R3G),(ZB,R1E,R2K,R3H),
(ZB,R1E,R2K,R3I),(ZB,R1E,R2K,R3J),(ZB,R1E,R2K,R3K),
(ZB,R1E,R2K,R3L),(ZB,R1E,R2K,R3M),(ZB,R1E,R2K,R3N),
(ZB,R1E,R2K,R3O),(ZB,R1E,R2K,R3P),(ZB,R1E,R2K,R3Q),
(ZB,R1E,R2K,R3R),(ZB,R1E,R2L,R3A),(ZB,R1E,R2L,R3B),
(ZB,R1E,R2L,R3C),(ZB,R1E,R2L,R3D),(ZB,R1E,R2L,R3E),
(ZB,R1E,R2L,R3F),(ZB,R1E,R2L,R3G),(ZB,R1E,R2L,R3H),
(ZB,R1E,R2L,R3I),(ZB,R1E,R2L,R3J),(ZB,R1E,R2L,R3K),
(ZB,R1E,R2L,R3L),(ZB,R1E,R2L,R3M),(ZB,R1E,R2L,R3N),
(ZB,R1E,R2L,R3O),(ZB,R1E,R2L,R3P),(ZB,R1E,R2L,R3Q),
(ZB,R1E,R2L,R3R),(ZB,R1E,R2M,R3A),(ZB,R1E,R2M,R3B),
(ZB,R1E,R2M,R3C),(ZB,R1E,R2M,R3D),(ZB,R1E,R2M,R3E),
(ZB,R1E,R2M,R3F),(ZB,R1E,R2M,R3G),(ZB,R1E,R2M,R3H),
(ZB,R1E,R2M,R3I),(ZB,R1E,R2M,R3J),(ZB,R1E,R2M,R3K),
(ZB,R1E,R2M,R3L),(ZB,R1E,R2M,R3M),(ZB,R1E,R2M,R3N),
(ZB,R1E,R2M,R3O),(ZB,R1E,R2M,R3P),(ZB,R1E,R2M,R3Q),
(ZB,R1E,R2M,R3R),(ZB,R1E,R2N,R3A),(ZB,R1E,R2N,R3B),
(ZB,R1E,R2N,R3C),(ZB,R1E,R2N,R3D),(ZB,R1E,R2N,R3E),
(ZB,R1E,R2N,R3F),(ZB,R1E,R2N,R3G),(ZB,R1E,R2N,R3H),
(ZB,R1E,R2N,R3I),(ZB,R1E,R2N,R3J),(ZB,R1E,R2N,R3K),
(ZB,R1E,R2N,R3L),(ZB,R1E,R2N,R3M),(ZB,R1E,R2N,R3N),
(ZB,R1E,R2N,R3O),(ZB,R1E,R2N,R3P),(ZB,R1E,R2N,R3Q),
(ZB,R1E,R2N,R3R),(ZB,R1F,R2A,R3A),(ZB,R1F,R2A,R3B),
(ZB,R1F,R2A,R3C),(ZB,R1F,R2A,R3D),(ZB,R1F,R2A,R3E),
(ZB,R1F,R2A,R3F),(ZB,R1F,R2A,R3G),(ZB,R1F,R2A,R3H),
(ZB,R1F,R2A,R3I),(ZB,R1F,R2A,R3J),(ZB,R1F,R2A,R3K),
(ZB,R1F,R2A,R3L),(ZB,R1F,R2A,R3M),(ZB,R1F,R2A,R3N),
(ZB,R1F,R2A,R3O),(ZB,R1F,R2A,R3P),(ZB,R1F,R2A,R3Q),
(ZB,R1F,R2A,R3R),(ZB,R1F,R2B,R3A),(ZB,R1F,R2B,R3B),
(ZB,R1F,R2B,R3C),(ZB,R1F,R2B,R3D),(ZB,R1F,R2B,R3E),
(ZB,R1F,R2B,R3F),(ZB,R1F,R2B,R3G),(ZB,R1F,R2B,R3H),
(ZB,R1F,R2B,R3I),(ZB,R1F,R2B,R3J),(ZB,R1F,R2B,R3K),
(ZB,R1F,R2B,R3L),(ZB,R1F,R2B,R3M),(ZB,R1F,R2B,R3N),
(ZB,R1F,R2B,R3O),(ZB,R1F,R2B,R3P),(ZB,R1F,R2B,R3Q),
(ZB,R1F,R2B,R3R),(ZB,R1F,R2C,R3A),(ZB,R1F,R2C,R3B),
(ZB,R1F,R2C,R3C),(ZB,R1F,R2C,R3D),(ZB,R1F,R2C,R3E),
(ZB,R1F,R2C,R3F),(ZB,R1F,R2C,R3G),(ZB,R1F,R2C,R3H),
(ZB,R1F,R2C,R3I),(ZB,R1F,R2C,R3J),(ZB,R1F,R2C,R3K),
(ZB,R1F,R2C,R3L),(ZB,R1F,R2C,R3M),(ZB,R1F,R2C,R3N),
(ZB,R1F,R2C,R3O),(ZB,R1F,R2C,R3P),(ZB,R1F,R2C,R3Q),
(ZB,R1F,R2C,R3R),(ZB,R1F,R2D,R3A),(ZB,R1F,R2D,R3B),
(ZB,R1F,R2D,R3C),(ZB,R1F,R2D,R3D),(ZB,R1F,R2D,R3E),
(ZB,R1F,R2D,R3F),(ZB,R1F,R2D,R3G),(ZB,R1F,R2D,R3H),
(ZB,R1F,R2D,R3I),(ZB,R1F,R2D,R3J),(ZB,R1F,R2D,R3K),
(ZB,R1F,R2D,R3L),(ZB,R1F,R2D,R3M),(ZB,R1F,R2D,R3N),
(ZB,R1F,R2D,R3O),(ZB,R1F,R2D,R3P),(ZB,R1F,R2D,R3Q),
(ZB,R1F,R2D,R3R),(ZB,R1F,R2E,R3A),(ZB,R1F,R2E,R3B),
(ZB,R1F,R2E,R3C),(ZB,R1F,R2E,R3D),(ZB,R1F,R2E,R3E),
(ZB,R1F,R2E,R3F),(ZB,R1F,R2E,R3G),(ZB,R1F,R2E,R3H),
(ZB,R1F,R2E,R3I),(ZB,R1F,R2E,R3J),(ZB,R1F,R2E,R3K),
(ZB,R1F,R2E,R3L),(ZB,R1F,R2E,R3M),(ZB,R1F,R2E,R3N),
(ZB,R1F,R2E,R3O),(ZB,R1F,R2E,R3P),(ZB,R1F,R2E,R3Q),
(ZB,R1F,R2E,R3R),(ZB,R1F,R2F,R3A),(ZB,R1F,R2F,R3B),
(ZB,R1F,R2F,R3C),(ZB,R1F,R2F,R3D),(ZB,R1F,R2F,R3E),
(ZB,R1F,R2F,R3F),(ZB,R1F,R2F,R3G),(ZB,R1F,R2F,R3H),
(ZB,R1F,R2F,R3I),(ZB,R1F,R2F,R3J),(ZB,R1F,R2F,R3K),
(ZB,R1F,R2F,R3L),(ZB,R1F,R2F,R3M),(ZB,R1F,R2F,R3N),
(ZB,R1F,R2F,R3O),(ZB,R1F,R2F,R3P),(ZB,R1F,R2F,R3Q),
(ZB,R1F,R2F,R3R),(ZB,R1F,R2G,R3A),(ZB,R1F,R2G,R3B),
(ZB,R1F,R2G,R3C),(ZB,R1F,R2G,R3D),(ZB,R1F,R2G,R3E),
(ZB,R1F,R2G,R3F),(ZB,R1F,R2G,R3G),(ZB,R1F,R2G,R3H),
(ZB,R1F,R2G,R3I),(ZB,R1F,R2G,R3J),(ZB,R1F,R2G,R3K),
(ZB,R1F,R2G,R3L),(ZB,R1F,R2G,R3M),(ZB,R1F,R2G,R3N),
(ZB,R1F,R2G,R3O),(ZB,R1F,R2G,R3P),(ZB,R1F,R2G,R3Q),
(ZB,R1F,R2G,R3R),(ZB,R1F,R2H,R3A),(ZB,R1F,R2H,R3B),
(ZB,R1F,R2H,R3C),(ZB,R1F,R2H,R3D),(ZB,R1F,R2H,R3E),
(ZB,R1F,R2H,R3F),(ZB,R1F,R2H,R3G),(ZB,R1F,R2H,R3H),
(ZB,R1F,R2H,R3I),(ZB,R1F,R2H,R3J),(ZB,R1F,R2H,R3K)
(ZB,R1F,R2H,R3L),(ZB,R1F,R2H,R3M),(ZB,R1F,R2H,R3N),
(ZB,R1F,R2H,R3O),(ZB,R1F,R2H,R3P),(ZB,R1F,R2H,R3Q),
(ZB,R1F,R2H,R3R),(ZB,R1F,R2I,R3A),(ZB,R1F,R2I,R3B),
(ZB,R1F,R2I,R3C),(ZB,R1F,R2I,R3D),(ZB,R1F,R2I,R3E),
(ZB,R1F,R2I,R3F),(ZB,R1F,R2I,R3G),(ZB,R1F,R2I,R3H),
(ZB,R1F,R2I,R3I),(ZB,R1F,R2I,R3J),(ZB,R1F,R2I,R3K),
(ZB,R1F,R2I,R3L),(ZB,R1F,R2I,R3M),(ZB,R1F,R2I,R3N),
(ZB,R1F,R2I,R3O),(ZB,R1F,R2I,R3P),(ZB,R1F,R2I,R3Q),
(ZB,R1F,R2I,R3R),(ZB,R1F,R2J,R3A),(ZB,R1F,R2J,R3B),
(ZB,R1F,R2J,R3C),(ZB,R1F,R2J,R3D),(ZB,R1F,R2J,R3E),
(ZB,R1F,R2J,R3F),(ZB,R1F,R2J,R3G),(ZB,R1F,R2J,R3H),
(ZB,R1F,R2J,R3I),(ZB,R1F,R2J,R3J),(ZB,R1F,R2J,R3K),
(ZB,R1F,R2J,R3L),(ZB,R1F,R2J,R3M),(ZB,R1F,R2J,R3N),
(ZB,R1F,R2J,R3O),(ZB,R1F,R2J,R3P),(ZB,R1F,R2J,R3Q),
(ZB,R1F,R2J,R3R),(ZB,R1F,R2K,R3A),(ZB,R1F,R2K,R3B),
(ZB,R1F,R2K,R3C),(ZB,R1F,R2K,R3D),(ZB,R1F,R2K,R3E),
(ZB,R1F,R2K,R3F),(ZB,R1F,R2K,R3G),(ZB,R1F,R2K,R3H),
(ZB,R1F,R2K,R3I),(ZB,R1F,R2K,R3J),(ZB,R1F,R2K,R3K),
(ZB,R1F,R2K,R3L),(ZB,R1F,R2K,R3M),(ZB,R1F,R2K,R3N),
(ZB,R1F,R2K,R3O),(ZB,R1F,R2K,R3P),(ZB,R1F,R2K,R3Q),
(ZB,R1F,R2K,R3R),(ZB,R1F,R2L,R3A),(ZB,R1F,R2L,R3B),
(ZB,R1F,R2L,R3C),(ZB,R1F,R2L,R3D),(ZB,R1F,R2L,R3E),
(ZB,R1F,R2L,R3F),(ZB,R1F,R2L,R3G),(ZB,R1F,R2L,R3H),
(ZB,R1F,R2L,R3I),(ZB,R1F,R2L,R3J),(ZB,R1F,R2L,R3K),
(ZB,R1F,R2L,R3L),(ZB,R1F,R2L,R3M),(ZB,R1F,R2L,R3N),
(ZB,R1F,R2L,R3O),(ZB,R1F,R2L,R3P),(ZB,R1F,R2L,R3Q),
(ZB,R1F,R2L,R3R),(ZB,R1F,R2M,R3A),(ZB,R1F,R2M,R3B),
(ZB,R1F,R2M,R3C),(ZB,R1F,R2M,R3D),(ZB,R1F,R2M,R3E),
(ZB,R1F,R2M,R3F),(ZB,R1F,R2M,R3G),(ZB,R1F,R2M,R3H),
(ZB,R1F,R2M,R3I),(ZB,R1F,R2M,R3J),(ZB,R1F,R2M,R3K),
(ZB,R1F,R2M,R3L),(ZB,R1F,R2M,R3M),(ZB,R1F,R2M,R3N),
(ZB,R1F,R2M,R3O),(ZB,R1F,R2M,R3P),(ZB,R1F,R2M,R3Q),
(ZB,R1F,R2M,R3R),(ZB,R1F,R2N,R3A),(ZB,R1F,R2N,R3B),
(ZB,R1F,R2N,R3C),(ZB,R1F,R2N,R3D),(ZB,R1F,R2N,R3E),
(ZB,R1F,R2N,R3F),(ZB,R1F,R2N,R3G),(ZB,R1F,R2N,R3H),
(ZB,R1F,R2N,R3I),(ZB,R1F,R2N,R3J),(ZB,R1F,R2N,R3K),
(ZB,R1F,R2N,R3L),(ZB,R1F,R2N,R3M),(ZB,R1F,R2N,R3N),
(ZB,R1F,R2N,R3O),(ZB,R1F,R2N,R3P),(ZB,R1F,R2N,R3Q),
(ZB,R1F,R2N,R3R),(ZB,R1G,R2A,R3A),(ZB,R1G,R2A,R3B),
(ZB,R1G,R2A,R3C),(ZB,R1G,R2A,R3D),(ZB,R1G,R2A,R3E),
(ZB,R1G,R2A,R3F),(ZB,R1G,R2A,R3G),(ZB,R1G,R2A,R3H),
(ZB,R1G,R2A,R3I),(ZB,R1G,R2A,R3J),(ZB,R1G,R2A,R3K),
(ZB,R1G,R2A,R3L),(ZB,R1G,R2A,R3M),(ZB,R1G,R2A,R3N),
(ZB,R1G,R2A,R3O),(ZB,R1G,R2A,R3P),(ZB,R1G,R2A,R3Q),
(ZB,R1G,R2A,R3R),(ZB,R1G,R2B,R3A),(ZB,R1G,R2B,R3B),
(ZB,R1G,R2B,R3C),(ZB,R1G,R2B,R3D),(ZB,R1G,R2B,R3E),
(ZB,R1G,R2B,R3F),(ZB,R1G,R2B,R3G),(ZB,R1G,R2B,R3H),
(ZB,R1G,R2B,R3I),(ZB,R1G,R2B,R3J),(ZB,R1G,R2B,R3K),
(ZB,R1G,R2B,R3L),(ZB,R1G,R2B,R3M),(ZB,R1G,R2B,R3N),
(ZB,R1G,R2B,R3O),(ZB,R1G,R2B,R3P),(ZB,R1G,R2B,R3Q),
(ZB,R1G,R2B,R3R),(ZB,R1G,R2C,R3A),(ZB,R1G,R2C,R3B),
(ZB,R1G,R2C,R3C),(ZB,R1G,R2C,R3D),(ZB,R1G,R2C,R3E),
(ZB,R1G,R2C,R3F),(ZB,R1G,R2C,R3G),(ZB,R1G,R2C,R3H),
(ZB,R1G,R2C,R3I),(ZB,R1G,R2C,R3J),(ZB,R1G,R2C,R3K),
(ZB,R1G,R2C,R3L),(ZB,R1G,R2C,R3M),(ZB,R1G,R2C,R3N),
(ZB,R1G,R2C,R3O),(ZB,R1G,R2C,R3P),(ZB,R1G,R2C,R3Q),
(ZB,R1G,R2C,R3R),(ZB,R1G,R2D,R3A),(ZB,R1G,R2D,R3B),
(ZB,R1G,R2D,R3C),(ZB,R1G,R2D,R3D),(ZB,R1G,R2D,R3E),
(ZB,R1G,R2D,R3F),(ZB,R1G,R2D,R3G),(ZB,R1G,R2D,R3H),
(ZB,R1G,R2D,R3I),(ZB,R1G,R2D,R3J),(ZB,R1G,R2D,R3K),
(ZB,R1G,R2D,R3L),(ZB,R1G,R2D,R3M),(ZB,R1G,R2D,R3N),
(ZB,R1G,R2D,R3O),(ZB,R1G,R2D,R3P),(ZB,R1G,R2D,R3Q),
(ZB,R1G,R2D,R3R),(ZB,R1G,R2E,R3A),(ZB,R1G,R2E,R3B),
(ZB,R1G,R2E,R3C),(ZB,R1G,R2E,R3D),(ZB,R1G,R2E,R3E),
(ZB,R1G,R2E,R3F),(ZB,R1G,R2E,R3G),(ZB,R1G,R2E,R3H),
(ZB,R1G,R2E,R3I),(ZB,R1G,R2E,R3J),(ZB,R1G,R2E,R3K),
(ZB,R1G,R2E,R3L),(ZB,R1G,R2E,R3M),(ZB,R1G,R2E,R3N),
(ZB,R1G,R2E,R3O),(ZB,R1G,R2E,R3P),(ZB,R1G,R2E,R3Q),
(ZB,R1G,R2E,R3R),(ZB,R1G,R2F,R3A),(ZB,R1G,R2F,R3B),
(ZB,R1G,R2F,R3C),(ZB,R1G,R2F,R3D),(ZB,R1G,R2F,R3E),
(ZB,R1G,R2F,R3F),(ZB,R1G,R2F,R3G),(ZB,R1G,R2F,R3H),
(ZB,R1G,R2F,R3I),(ZB,R1G,R2F,R3J),(ZB,R1G,R2F,R3K),
(ZB,R1G,R2F,R3L),(ZB,R1G,R2F,R3M),(ZB,R1G,R2F,R3N),
(ZB,R1G,R2F,R3O),(ZB,R1G,R2F,R3P),(ZB,R1G,R2F,R3Q),
(ZB,R1G,R2F,R3R),(ZB,R1G,R2G,R3A),(ZB,R1G,R2G,R3B),
(ZB,R1G,R2G,R3C),(ZB,R1G,R2G,R3D),(ZB,R1G,R2G,R3E),
(ZB,R1G,R2G,R3F),(ZB,R1G,R2G,R3G),(ZB,R1G,R2G,R3H),
(ZB,R1G,R2G,R3I),(ZB,R1G,R2G,R3J),(ZB,R1G,R2G,R3K),
(ZB,R1G,R2G,R3L),(ZB,R1G,R2G,R3M),(ZB,R1G,R2G,R3N),
(ZB,R1G,R2G,R3O),(ZB,R1G,R2G,R3P),(ZB,R1G,R2G,R3Q),
(ZB,R1G,R2G,R3R),(ZB,R1G,R2H,R3A),(ZB,R1G,R2H,R3B),
(ZB,R1G,R2H,R3C),(ZB,R1G,R2H,R3D),(ZB,R1G,R2H,R3E),
(ZB,R1G,R2H,R3F),(ZB,R1G,R2H,R3G),(ZB,R1G,R2H,R3H),
(ZB,R1G,R2H,R3I),(ZB,R1G,R2H,R3J),(ZB,R1G,R2H,R3K),
(ZB,R1G,R2H,R3L),(ZB,R1G,R2H,R3M),(ZB,R1G,R2H,R3N),
(ZB,R1G,R2H,R3O),(ZB,R1G,R2H,R3P),(ZB,R1G,R2H,R3Q),
(ZB,R1G,R2H,R3R),(ZB,R1G,R2I,R3A),(ZB,R1G,R2I,R3B),
(ZB,R1G,R2I,R3C),(ZB,R1G,R2I,R3D),(ZB,R1G,R2I,R3E),
(ZB,R1G,R2I,R3F),(ZB,R1G,R2I,R3G),(ZB,R1G,R2I,R3H),
(ZB,R1G,R2I,R3I),(ZB,R1G,R2I,R3J),(ZB,R1G,R2I,R3K),
(ZB,R1G,R2I,R3L),(ZB,R1G,R2I,R3M),(ZB,R1G,R2I,R3N),
(ZB,R1G,R2I,R3O),(ZB,R1G,R2I,R3P),(ZB,R1G,R2I,R3Q),
(ZB,R1G,R2I,R3R),(ZB,R1G,R2J,R3A),(ZB,R1G,R2J,R3B),
(ZB,R1G,R2J,R3C),(ZB,R1G,R2J,R3D),(ZB,R1G,R2J,R3E),
(ZB,R1G,R2J,R3F),(ZB,R1G,R2J,R3G),(ZB,R1G,R2J,R3H),
(ZB,R1G,R2J,R3I),(ZB,R1G,R2J,R3J),(ZB,R1G,R2J,R3K),
(ZB,R1G,R2J,R3L),(ZB,R1G,R2J,R3M),(ZB,R1G,R2J,R3N),
(ZB,R1G,R2J,R3O),(ZB,R1G,R2J,R3P),(ZB,R1G,R2J,R3Q),
(ZB,R1G,R2J,R3R),(ZB,R1G,R2K,R3A),(ZB,R1G,R2K,R3B),
(ZB,R1G,R2K,R3C),(ZB,R1G,R2K,R3D),(ZB,R1G,R2K,R3E),
(ZB,R1G,R2K,R3F),(ZB,R1G,R2K,R3G),(ZB,R1G,R2K,R3H),
(ZB,R1G,R2K,R3I),(ZB,R1G,R2K,R3J),(ZB,R1G,R2K,R3K),
(ZB,R1G,R2K,R3L),(ZB,R1G,R2K,R3M),(ZB,R1G,R2K,R3N),
(ZB,R1G,R2K,R3O),(ZB,R1G,R2K,R3P),(ZB,R1G,R2K,R3Q),
(ZB,R1G,R2K,R3R),(ZB,R1G,R2L,R3A),(ZB,R1G,R2L,R3B),
(ZB,R1G,R2L,R3C),(ZB,R1G,R2L,R3D),(ZB,R1G,R2L,R3E),
(ZB,R1G,R2L,R3F),(ZB,R1G,R2L,R3G),(ZB,R1G,R2L,R3H),
(ZB,R1G,R2L,R3I),(ZB,R1G,R2L,R3J),(ZB,R1G,R2L,R3K),
(ZB,R1G,R2L,R3L),(ZB,R1G,R2L,R3M),(ZB,R1G,R2L,R3N),
(ZB,R1G,R2L,R3O),(ZB,R1G,R2L,R3P),(ZB,R1G,R2L,R3Q),
(ZB,R1G,R2L,R3R),(ZB,R1G,R2M,R3A),(ZB,R1G,R2M,R3B),
(ZB,R1G,R2M,R3C),(ZB,R1G,R2M,R3D),(ZB,R1G,R2M,R3E),
(ZB,R1G,R2M,R3F),(ZB,R1G,R2M,R3G),(ZB,R1G,R2M,R3H),
(ZB,R1G,R2M,R3I),(ZB,R1G,R2M,R3J),(ZB,R1G,R2M,R3K),
(ZB,R1G,R2M,R3L),(ZB,R1G,R2M,R3M),(ZB,R1G,R2M,R3N),
(ZB,R1G,R2M,R3O),(ZB,R1G,R2M,R3P),(ZB,R1G,R2M,R3Q),
(ZB,R1G,R2M,R3R),(ZB,R1G,R2N,R3A),(ZB,R1G,R2N,R3B),
(ZB,R1G,R2N,R3C),(ZB,R1G,R2N,R3D),(ZB,R1G,R2N,R3E),
(ZB,R1G,R2N,R3F),(ZB,R1G,R2N,R3G),(ZB,R1G,R2N,R3H),
(ZB,R1G,R2N,R3I),(ZB,R1G,R2N,R3J),(ZB,R1G,R2N,R3K),
(ZB,R1G,R2N,R3L),(ZB,R1G,R2N,R3M),(ZB,R1G,R2N,R3N),
(ZB,R1G,R2N,R3O),(ZB,R1G,R2N,R3P),(ZB,R1G,R2N,R3Q),
(ZB,R1G,R2N,R3R),(ZB,R1H,R2A,R3A),(ZB,R1H,R2A,R3B),
(ZB,R1H,R2A,R3C),(ZB,R1H,R2A,R3D),(ZB,R1H,R2A,R3E),
(ZB,R1H,R2A,R3F),(ZB,R1H,R2A,R3G),(ZB,R1H,R2A,R3H),
(ZB,R1H,R2A,R3I),(ZB,R1H,R2A,R3J),(ZB,R1H,R2A,R3K),
(ZB,R1H,R2A,R3L),(ZB,R1H,R2A,R3M),(ZB,R1H,R2A,R3N),
(ZB,R1H,R2A,R3O),(ZB,R1H,R2A,R3P),(ZB,R1H,R2A,R3Q),
(ZB,R1H,R2A,R3R),(ZB,R1H,R2B,R3A),(ZB,R1H,R2B,R3B),
(ZB,R1H,R2B,R3C),(ZB,R1H,R2B,R3D),(ZB,R1H,R2B,R3E),
(ZB,R1H,R2B,R3F),(ZB,R1H,R2B,R3G),(ZB,R1H,R2B,R3H),
(ZB,R1H,R2B,R3I),(ZB,R1H,R2B,R3J),(ZB,R1H,R2B,R3K),
(ZB,R1H,R2B,R3L),(ZB,R1H,R2B,R3M),(ZB,R1H,R2B,R3N),
(ZB,R1H,R2B,R3O),(ZB,R1H,R2B,R3P),(ZB,R1H,R2B,R3Q),
(ZB,R1H,R2B,R3R),(ZB,R1H,R2C,R3A),(ZB,R1H,R2C,R3B),
(ZB,R1H,R2C,R3C),(ZB,R1H,R2C,R3D),(ZB,R1H,R2C,R3E),
(ZB,R1H,R2C,R3F),(ZB,R1H,R2C,R3G),(ZB,R1H,R2C,R3H),
(ZB,R1H,R2C,R3I),(ZB,R1H,R2C,R3J),(ZB,R1H,R2C,R3K),
(ZB,R1H,R2C,R3L),(ZB,R1H,R2C,R3M),(ZB,R1H,R2C,R3N),
(ZB,R1H,R2C,R3O),(ZB,R1H,R2C,R3P),(ZB,R1H,R2C,R3Q),
(ZB,R1H,R2C,R3R),(ZB,R1H,R2D,R3A),(ZB,R1H,R2D,R3B),
(ZB,R1H,R2D,R3C),(ZB,R1H,R2D,R3D),(ZB,R1H,R2D,R3E),
(ZB,R1H,R2D,R3F),(ZB,R1H,R2D,R3G),(ZB,R1H,R2D,R3H),
(ZB,R1H,R2D,R3I),(ZB,R1H,R2D,R3J),(ZB,R1H,R2D,R3K),
(ZB,R1H,R2D,R3L),(ZB,R1H,R2D,R3M),(ZB,R1H,R2D,R3N),
(ZB,R1H,R2D,R3O),(ZB,R1H,R2D,R3P),(ZB,R1H,R2D,R3Q),
(ZB,R1H,R2D,R3R),(ZB,R1H,R2E,R3A),(ZB,R1H,R2E,R3B),
(ZB,R1H,R2E,R3C),(ZB,R1H,R2E,R3D),(ZB,R1H,R2E,R3E),
(ZB,R1H,R2E,R3F),(ZB,R1H,R2E,R3G),(ZB,R1H,R2E,R3H),
(ZB,R1H,R2E,R3I),(ZB,R1H,R2E,R3J),(ZB,R1H,R2E,R3K),
(ZB,R1H,R2E,R3L),(ZB,R1H,R2E,R3M),(ZB,R1H,R2E,R3N),
(ZB,R1H,R2E,R3O),(ZB,R1H,R2E,R3P),(ZB,R1H,R2E,R3Q),
(ZB,R1H,R2E,R3R),(ZB,R1H,R2F,R3A),(ZB,R1H,R2F,R3B),
(ZB,R1H,R2F,R3C),(ZB,R1H,R2F,R3D),(ZB,R1H,R2F,R3E),
(ZB,R1H,R2F,R3F),(ZB,R1H,R2F,R3G),(ZB,R1H,R2F,R3H),
(ZB,R1H,R2F,R3I),(ZB,R1H,R2F,R3J),(ZB,R1H,R2F,R3K),
(ZB,R1H,R2F,R3L),(ZB,R1H,R2F,R3M),(ZB,R1H,R2F,R3N),
(ZB,R1H,R2F,R3O),(ZB,R1H,R2F,R3P),(ZB,R1H,R2F,R3Q),
(ZB,R1H,R2F,R3R),(ZB,R1H,R2G,R3A),(ZB,R1H,R2G,R3B),
(ZB,R1H,R2G,R3C),(ZB,R1H,R2G,R3D),(ZB,R1H,R2G,R3E),
(ZB,R1H,R2G,R3F),(ZB,R1H,R2G,R3G),(ZB,R1H,R2G,R3H),
(ZB,R1H,R2G,R3I),(ZB,R1H,R2G,R3J),(ZB,R1H,R2G,R3K),
(ZB,R1H,R2G,R3L),(ZB,R1H,R2G,R3M),(ZB,R1H,R2G,R3N),
(ZB,R1H,R2G,R3O),(ZB,R1H,R2G,R3P),(ZB,R1H,R2G,R3Q),
(ZB,R1H,R2G,R3R),(ZB,R1H,R2H,R3A),(ZB,R1H,R2H,R3B),
(ZB,R1H,R2H,R3C),(ZB,R1H,R2H,R3D),(ZB,R1H,R2H,R3E),
(ZB,R1H,R2H,R3F),(ZB,R1H,R2H,R3G),(ZB,R1H,R2H,R3H),
(ZB,R1H,R2H,R3I),(ZB,R1H,R2H,R3J),(ZB,R1H,R2H,R3K),
(ZB,R1H,R2H,R3L),(ZB,R1H,R2H,R3M),(ZB,R1H,R2H,R3N),
(ZB,R1H,R2H,R3O),(ZB,R1H,R2H,R3P),(ZB,R1H,R2H,R3Q),
(ZB,R1H,R2H,R3R),(ZB,R1H,R2I,R3A),(ZB,R1H,R2I,R3B),
(ZB,R1H,R2I,R3C),(ZB,R1H,R2I,R3D),(ZB,R1H,R2I,R3E),
(ZB,R1H,R2I,R3F),(ZB,R1H,R2I,R3G),(ZB,R1H,R2I,R3H),
(ZB,R1H,R2I,R3I),(ZB,R1H,R2I,R3J),(ZB,R1H,R2I,R3K),
(ZB,R1H,R2I,R3L),(ZB,R1H,R2I,R3M),(ZB,R1H,R2I,R3N),
(ZB,R1H,R2I,R3O),(ZB,R1H,R2I,R3P),(ZB,R1H,R2I,R3Q),
(ZB,R1H,R2I,R3R),(ZB,R1H,R2J,R3A),(ZB,R1H,R2J,R3B),
(ZB,R1H,R2J,R3C),(ZB,R1H,R2J,R3D),(ZB,R1H,R2J,R3E),
(ZB,R1H,R2J,R3F),(ZB,R1H,R2J,R3G),(ZB,R1H,R2J,R3H),
(ZB,R1H,R2J,R3I),(ZB,R1H,R2J,R3J),(ZB,R1H,R2J,R3K),
(ZB,R1H,R2J,R3L),(ZB,R1H,R2J,R3M),(ZB,R1H,R2J,R3N),
(ZB,R1H,R2J,R3O),(ZB,R1H,R2J,R3P),(ZB,R1H,R2J,R3Q),
(ZB,R1H,R2J,R3R),(ZB,R1H,R2K,R3A),(ZB,R1H,R2K,R3B),
(ZB,R1H,R2K,R3C),(ZB,R1H,R2K,R3D),(ZB,R1H,R2K,R3E),
(ZB,R1H,R2K,R3F),(ZB,R1H,R2K,R3G),(ZB,R1H,R2K,R3H),
(ZB,R1H,R2K,R3I),(ZB,R1H,R2K,R3J),(ZB,R1H,R2K,R3K),
(ZB,R1H,R2K,R3L),(ZB,R1H,R2K,R3M),(ZB,R1H,R2K,R3N),
(ZB,R1H,R2K,R3O),(ZB,R1H,R2K,R3P),(ZB,R1H,R2K,R3Q),
(ZB,R1H,R2K,R3R),(ZB,R1H,R2L,R3A),(ZB,R1H,R2L,R3B),
(ZB,R1H,R2L,R3C),(ZB,R1H,R2L,R3D),(ZB,R1H,R2L,R3E),
(ZB,R1H,R2L,R3F),(ZB,R1H,R2L,R3G),(ZB,R1H,R2L,R3H),
(ZB,R1H,R2L,R3I),(ZB,R1H,R2L,R3J),(ZB,R1H,R2L,R3K),
(ZB,R1H,R2L,R3L),(ZB,R1H,R2L,R3M),(ZB,R1H,R2L,R3N),
(ZB,R1H,R2L,R3O),(ZB,R1H,R2L,R3P),(ZB,R1H,R2L,R3Q),
(ZB,R1H,R2L,R3R),(ZB,R1H,R2M,R3A),(ZB,R1H,R2M,R3B),
(ZB,R1H,R2M,R3C),(ZB,R1H,R2M,R3D),(ZB,R1H,R2M,R3E),
(ZB,R1H,R2M,R3F),(ZB,R1H,R2M,R3G),(ZB,R1H,R2M,R3H),
(ZB,R1H,R2M,R3I),(ZB,R1H,R2M,R3J),(ZB,R1H,R2M,R3K),
(ZB,R1H,R2M,R3L),(ZB,R1H,R2M,R3M),(ZB,R1H,R2M,R3N),
(ZB,R1H,R2M,R3O),(ZB,R1H,R2M,R3P),(ZB,R1H,R2M,R3Q),
(ZB,R1H,R2M,R3R),(ZB,R1H,R2N,R3A),(ZB,R1H,R2N,R3B),
(ZB,R1H,R2N,R3C),(ZB,R1H,R2N,R3D),(ZB,R1H,R2N,R3E),
(ZB,R1H,R2N,R3F),(ZB,R1H,R2N,R3G),(ZB,R1H,R2N,R3H),
(ZB,R1H,R2N,R3I),(ZB,R1H,R2N,R3J),(ZB,R1H,R2N,R3K),
(ZB,R1H,R2N,R3L),(ZB,R1H,R2N,R3M),(ZB,R1H,R2N,R3N),
(ZB,R1H,R2N,R3O),(ZB,R1H,R2N,R3P),(ZB,R1H,R2N,R3Q),
(ZB,R1H,R2N,R3R),(ZB,R1I,R2A,R3A),(ZB,R1I,R2A,R3B),
(ZB,R1I,R2A,R3C),(ZB,R1I,R2A,R3D),(ZB,R1I,R2A,R3E),
(ZB,R1I,R2A,R3F),(ZB,R1I,R2A,R3G),(ZB,R1I,R2A,R3H),
(ZB,R1I,R2A,R3I),(ZB,R1I,R2A,R3J),(ZB,R1I,R2A,R3K),
(ZB,R1I,R2A,R3L),(ZB,R1I,R2A,R3M),(ZB,R1I,R2A,R3N),
(ZB,R1I,R2A,R3O),(ZB,R1I,R2A,R3P),(ZB,R1I,R2A,R3Q),
(ZB,R1I,R2A,R3R),(ZB,R1I,R2B,R3A),(ZB,R1I,R2B,R3B),
(ZB,R1I,R2B,R3C),(ZB,R1I,R2B,R3D),(ZB,R1I,R2B,R3E),
(ZB,R1I,R2B,R3F),(ZB,R1I,R2B,R3G),(ZB,R1I,R2B,R3H),
(ZB,R1I,R2B,R3I),(ZB,R1I,R2B,R3J),(ZB,R1I,R2B,R3K),
(ZB,R1I,R2B,R3L),(ZB,R1I,R2B,R3M),(ZB,R1I,R2B,R3N),
(ZB,R1I,R2B,R3O),(ZB,R1I,R2B,R3P),(ZB,R1I,R2B,R3Q),
(ZB,R1I,R2B,R3R),(ZB,R1I,R2C,R3A),(ZB,R1I,R2C,R3B),
(ZB,R1I,R2C,R3C),(ZB,R1I,R2C,R3D),(ZB,R1I,R2C,R3E),
(ZB,R1I,R2C,R3F),(ZB,R1I,R2C,R3G),(ZB,R1I,R2C,R3H),
(ZB,R1I,R2C,R3I),(ZB,R1I,R2C,R3J),(ZB,R1I,R2C,R3K),
(ZB,R1I,R2C,R3L),(ZB,R1I,R2C,R3M),(ZB,R1I,R2C,R3N),
(ZB,R1I,R2C,R3O),(ZB,R1I,R2C,R3P),(ZB,R1I,R2C,R3Q),
(ZB,R1I,R2C,R3R),(ZB,R1I,R2D,R3A),(ZB,R1I,R2D,R3B),
(ZB,R1I,R2D,R3C),(ZB,R1I,R2D,R3D),(ZB,R1I,R2D,R3E),
(ZB,R1I,R2D,R3F),(ZB,R1I,R2D,R3G),(ZB,R1I,R2D,R3H),
(ZB,R1I,R2D,R3I),(ZB,R1I,R2D,R3J),(ZB,R1I,R2D,R3K),
(ZB,R1I,R2D,R3L),(ZB,R1I,R2D,R3M),(ZB,R1I,R2D,R3N),
(ZB,R1I,R2D,R3O),(ZB,R1I,R2D,R3P),(ZB,R1I,R2D,R3Q),
(ZB,R1I,R2D,R3R),(ZB,R1I,R2E,R3A),(ZB,R1I,R2E,R3B),
(ZB,R1I,R2E,R3C),(ZB,R1I,R2E,R3D),(ZB,R1I,R2E,R3E),
(ZB,R1I,R2E,R3F),(ZB,R1I,R2E,R3G),(ZB,R1I,R2E,R3H),
(ZB,R1I,R2E,R3I),(ZB,R1I,R2E,R3J),(ZB,R1I,R2E,R3K),
(ZB,R1I,R2E,R3L),(ZB,R1I,R2E,R3M),(ZB,R1I,R2E,R3N),
(ZB,R1I,R2E,R3O),(ZB,R1I,R2E,R3P),(ZB,R1I,R2E,R3Q),
(ZB,R1I,R2E,R3R),(ZB,R1I,R2F,R3A),(ZB,R1I,R2F,R3B),
(ZB,R1I,R2F,R3C),(ZB,R1I,R2F,R3D),(ZB,R1I,R2F,R3E),
(ZB,R1I,R2F,R3F),(ZB,R1I,R2F,R3G),(ZB,R1I,R2F,R3H),
(ZB,R1I,R2F,R3I),(ZB,R1I,R2F,R3J),(ZB,R1I,R2F,R3K),
(ZB,R1I,R2F,R3L),(ZB,R1I,R2F,R3M),(ZB,R1I,R2F,R3N),
(ZB,R1I,R2F,R3O),(ZB,R1I,R2F,R3P),(ZB,R1I,R2F,R3Q),
(ZB,R1I,R2F,R3R),(ZB,R1I,R2G,R3A),(ZB,R1I,R2G,R3B),
(ZB,R1I,R2G,R3C),(ZB,R1I,R2G,R3D),(ZB,R1I,R2G,R3E),
(ZB,R1I,R2G,R3F),(ZB,R1I,R2G,R3G),(ZB,R1I,R2G,R3H),
(ZB,R1I,R2G,R3I),(ZB,R1I,R2G,R3J),(ZB,R1I,R2G,R3K),
(ZB,R1I,R2G,R3L),(ZB,R1I,R2G,R3M),(ZB,R1I,R2G,R3N),
(ZB,R1I,R2G,R3O),(ZB,R1I,R2G,R3P),(ZB,R1I,R2G,R3Q),
(ZB,R1I,R2G,R3R),(ZB,R1I,R2H,R3A),(ZB,R1I,R2H,R3B),
(ZB,R1I,R2H,R3C),(ZB,R1I,R2H,R3D),(ZB,R1I,R2H,R3E),
(ZB,R1I,R2H,R3F),(ZB,R1I,R2H,R3G),(ZB,R1I,R2H,R3H),
(ZB,R1I,R2H,R3I),(ZB,R1I,R2H,R3J),(ZB,R1I,R2H,R3K),
(ZB,R1I,R2H,R3L),(ZB,R1I,R2H,R3M),(ZB,R1I,R2H,R3N),
(ZB,R1I,R2H,R3O),(ZB,R1I,R2H,R3P),(ZB,R1I,R2H,R3Q),
(ZB,R1I,R2H,R3R),(ZB,R1I,R2I,R3A),(ZB,R1I,R2I,R3B),
(ZB,R1I,R2I,R3C),(ZB,R1I,R2I,R3D),(ZB,R1I,R2I,R3E),
(ZB,R1I,R2I,R3F),(ZB,R1I,R2I,R3G),(ZB,R1I,R2I,R3H),
(ZB,R1I,R2I,R3I),(ZB,R1I,R2I,R3J),(ZB,R1I,R2I,R3K),
(ZB,R1I,R2I,R3L),(ZB,R1I,R2I,R3M),(ZB,R1I,R2I,R3N),
(ZB,R1I,R2I,R3O),(ZB,R1I,R2I,R3P),(ZB,R1I,R2I,R3Q),
(ZB,R1I,R2I,R3R),(ZB,R1I,R2J,R3A),(ZB,R1I,R2J,R3B),
(ZB,R1I,R2J,R3C),(ZB,R1I,R2J,R3D),(ZB,R1I,R2J,R3E),
(ZB,R1I,R2J,R3F),(ZB,R1I,R2J,R3G),(ZB,R1I,R2J,R3H),
(ZB,R1I,R2J,R3I),(ZB,R1I,R2J,R3J),(ZB,R1I,R2J,R3K),
(ZB,R1I,R2J,R3L),(ZB,R1I,R2J,R3M),(ZB,R1I,R2J,R3N),
(ZB,R1I,R2J,R3O),(ZB,R1I,R2J,R3P),(ZB,R1I,R2J,R3Q),
(ZB,R1I,R2J,R3R),(ZB,R1I,R2K,R3A),(ZB,R1I,R2K,R3B),
(ZB,R1I,R2K,R3C),(ZB,R1I,R2K,R3D),(ZB,R1I,R2K,R3E),
(ZB,R1I,R2K,R3F),(ZB,R1I,R2K,R3G),(ZB,R1I,R2K,R3H),
(ZB,R1I,R2K,R3I),(ZB,R1I,R2K,R3J),(ZB,R1I,R2K,R3K),
(ZB,R1I,R2K,R3L),(ZB,R1I,R2K,R3M),(ZB,R1I,R2K,R3N),
(ZB,R1I,R2K,R3O),(ZB,R1I,R2K,R3P),(ZB,R1I,R2K,R3Q),
(ZB,R1I,R2K,R3R),(ZB,R1I,R2L,R3A),(ZB,R1I,R2L,R3B),
(ZB,R1I,R2L,R3C),(ZB,R1I,R2L,R3D),(ZB,R1I,R2L,R3E),
(ZB,R1I,R2L,R3F),(ZB,R1I,R2L,R3G),(ZB,R1I,R2L,R3H),
(ZB,R1I,R2L,R3I),(ZB,R1I,R2L,R3J),(ZB,R1I,R2L,R3K),
(ZB,R1I,R2L,R3L),(ZB,R1I,R2L,R3M),(ZB,R1I,R2L,R3N),
(ZB,R1I,R2L,R3O),(ZB,R1I,R2L,R3P),(ZB,R1I,R2L,R3Q),
(ZB,R1I,R2L,R3R),(ZB,R1I,R2M,R3A),(ZB,R1I,R2M,R3B),
(ZB,R1I,R2M,R3C),(ZB,R1I,R2M,R3D),(ZB,R1I,R2M,R3E),
(ZB,R1I,R2M,R3F),(ZB,R1I,R2M,R3G),(ZB,R1I,R2M,R3H),
(ZB,R1I,R2M,R3I),(ZB,R1I,R2M,R3J),(ZB,R1I,R2M,R3K),
(ZB,R1I,R2M,R3L),(ZB,R1I,R2M,R3M),(ZB,R1I,R2M,R3N),
(ZB,R1I,R2M,R3O),(ZB,R1I,R2M,R3P),(ZB,R1I,R2M,R3Q),
(ZB,R1I,R2M,R3R),(ZB,R1I,R2N,R3A),(ZB,R1I,R2N,R3B),
(ZB,R1I,R2N,R3C),(ZB,R1I,R2N,R3D),(ZB,R1I,R2N,R3E),
(ZB,R1I,R2N,R3F),(ZB,R1I,R2N,R3G),(ZB,R1I,R2N,R3H),
(ZB,R1I,R2N,R3I),(ZB,R1I,R2N,R3J),(ZB,R1I,R2N,R3K),
(ZB,R1I,R2N,R3L),(ZB,R1I,R2N,R3M),(ZB,R1I,R2N,R3N),
(ZB,R1I,R2N,R3O),(ZB,R1I,R2N,R3P),(ZB,R1I,R2N,R3Q),
(ZB,R1I,R2N,R3R),(ZB,R1J,R2A,R3A),(ZB,R1J,R2A,R3B),
(ZB,R1J,R2A,R3C),(ZB,R1J,R2A,R3D),(ZB,R1J,R2A,R3E),
(ZB,R1J,R2A,R3F),(ZB,R1J,R2A,R3G),(ZB,R1J,R2A,R3H),
(ZB,R1J,R2A,R3I),(ZB,R1J,R2A,R3J),(ZB,R1J,R2A,R3K),
(ZB,R1J,R2A,R3L),(ZB,R1J,R2A,R3M),(ZB,R1J,R2A,R3N),
(ZB,R1J,R2A,R3O),(ZB,R1J,R2A,R3P),(ZB,R1J,R2A,R3Q),
(ZB,R1J,R2A,R3R),(ZB,R1J,R2B,R3A),(ZB,R1J,R2B,R3B),
(ZB,R1J,R2B,R3C),(ZB,R1J,R2B,R3D),(ZB,R1J,R2B,R3E),
(ZB,R1J,R2B,R3F),(ZB,R1J,R2B,R3G),(ZB,R1J,R2B,R3H),
(ZB,R1J,R2B,R3I),(ZB,R1J,R2B,R3J),(ZB,R1J,R2B,R3K),
(ZB,R1J,R2B,R3L),(ZB,R1J,R2B,R3M),(ZB,R1J,R2B,R3N),
(ZB,R1J,R2B,R3O),(ZB,R1J,R2B,R3P),(ZB,R1J,R2B,R3Q),
(ZB,R1J,R2B,R3R),(ZB,R1J,R2C,R3A),(ZB,R1J,R2C,R3B),
(ZB,R1J,R2C,R3C),(ZB,R1J,R2C,R3D),(ZB,R1J,R2C,R3E),
(ZB,R1J,R2C,R3F),(ZB,R1J,R2C,R3G),(ZB,R1J,R2C,R3H),
(ZB,R1J,R2C,R3I),(ZB,R1J,R2C,R3J),(ZB,R1J,R2C,R3K),
(ZB,R1J,R2C,R3L),(ZB,R1J,R2C,R3M),(ZB,R1J,R2C,R3N),
(ZB,R1J,R2C,R3O),(ZB,R1J,R2C,R3P),(ZB,R1J,R2C,R3Q),
(ZB,R1J,R2C,R3R),(ZB,R1J,R2D,R3A),(ZB,R1J,R2D,R3B),
(ZB,R1J,R2D,R3C),(ZB,R1J,R2D,R3D),(ZB,R1J,R2D,R3E),
(ZB,R1J,R2D,R3F),(ZB,R1J,R2D,R3G),(ZB,R1J,R2D,R3H),
(ZB,R1J,R2D,R3I),(ZB,R1J,R2D,R3J),(ZB,R1J,R2D,R3K),
(ZB,R1J,R2D,R3L),(ZB,R1J,R2D,R3M),(ZB,R1J,R2D,R3N),
(ZB,R1J,R2D,R3O),(ZB,R1J,R2D,R3P),(ZB,R1J,R2D,R3Q),
(ZB,R1J,R2D,R3R),(ZB,R1J,R2E,R3A),(ZB,R1J,R2E,R3B),
(ZB,R1J,R2E,R3C),(ZB,R1J,R2E,R3D),(ZB,R1J,R2E,R3E),
(ZB,R1J,R2E,R3F),(ZB,R1J,R2E,R3G),(ZB,R1J,R2E,R3H),
(ZB,R1J,R2E,R3I),(ZB,R1J,R2E,R3J),(ZB,R1J,R2E,R3K),
(ZB,R1J,R2E,R3L),(ZB,R1J,R2E,R3M),(ZB,R1J,R2E,R3N),
(ZB,R1J,R2E,R3O),(ZB,R1J,R2E,R3P),(ZB,R1J,R2E,R3Q),
(ZB,R1J,R2E,R3R),(ZB,R1J,R2F,R3A),(ZB,R1J,R2F,R3B),
(ZB,R1J,R2F,R3C),(ZB,R1J,R2F,R3D),(ZB,R1J,R2F,R3E),
(ZB,R1J,R2F,R3F),(ZB,R1J,R2F,R3G),(ZB,R1J,R2F,R3H),
(ZB,R1J,R2F,R3I),(ZB,R1J,R2F,R3J),(ZB,R1J,R2F,R3K),
(ZB,R1J,R2F,R3L),(ZB,R1J,R2F,R3M),(ZB,R1J,R2F,R3N),
(ZB,R1J,R2F,R3O),(ZB,R1J,R2F,R3P),(ZB,R1J,R2F,R3Q),
(ZB,R1J,R2F,R3R),(ZB,R1J,R2G,R3A),(ZB,R1J,R2G,R3B),
(ZB,R1J,R2G,R3C),(ZB,R1J,R2G,R3D),(ZB,R1J,R2G,R3E),
(ZB,R1J,R2G,R3F),(ZB,R1J,R2G,R3G),(ZB,R1J,R2G,R3H),
(ZB,R1J,R2G,R3I),(ZB,R1J,R2G,R3J),(ZB,R1J,R2G,R3K),
(ZB,R1J,R2G,R3L),(ZB,R1J,R2G,R3M),(ZB,R1J,R2G,R3N),
(ZB,R1J,R2G,R3O),(ZB,R1J,R2G,R3P),(ZB,R1J,R2G,R3Q),
(ZB,R1J,R2G,R3R),(ZB,R1J,R2H,R3A),(ZB,R1J,R2H,R3B),
(ZB,R1J,R2H,R3C),(ZB,R1J,R2H,R3D),(ZB,R1J,R2H,R3E),
(ZB,R1J,R2H,R3F),(ZB,R1J,R2H,R3G),(ZB,R1J,R2H,R3H),
(ZB,R1J,R2H,R3I),(ZB,R1J,R2H,R3J),(ZB,R1J,R2H,R3K),
(ZB,R1J,R2H,R3L),(ZB,R1J,R2H,R3M),(ZB,R1J,R2H,R3N),
(ZB,R1J,R2H,R3O),(ZB,R1J,R2H,R3P),(ZB,R1J,R2H,R3Q),
(ZB,R1J,R2H,R3R),(ZB,R1J,R2I,R3A),(ZB,R1J,R2I,R3B),
(ZB,R1J,R2I,R3C),(ZB,R1J,R2I,R3D),(ZB,R1J,R2I,R3E),
(ZB,R1J,R2I,R3F),(ZB,R1J,R2I,R3G),(ZB,R1J,R2I,R3H),
(ZB,R1J,R2I,R3I),(ZB,R1J,R2I,R3J),(ZB,R1J,R2I,R3K),
(ZB,R1J,R2I,R3L),(ZB,R1J,R2I,R3M),(ZB,R1J,R2I,R3N),
(ZB,R1J,R2I,R3O),(ZB,R1J,R2I,R3P),(ZB,R1J,R2I,R3Q),
(ZB,R1J,R2I,R3R),(ZB,R1J,R2J,R3A),(ZB,R1J,R2J,R3B),
(ZB,R1J,R2J,R3C),(ZB,R1J,R2J,R3D),(ZB,R1J,R2J,R3E),
(ZB,R1J,R2J,R3F),(ZB,R1J,R2J,R3G),(ZB,R1J,R2J,R3H),
(ZB,R1J,R2J,R3I),(ZB,R1J,R2J,R3J),(ZB,R1J,R2J,R3K),
(ZB,R1J,R2J,R3L),(ZB,R1J,R2J,R3M),(ZB,R1J,R2J,R3N),
(ZB,R1J,R2J,R3O),(ZB,R1J,R2J,R3P),(ZB,R1J,R2J,R3Q),
(ZB,R1J,R2J,R3R),(ZB,R1J,R2K,R3A),(ZB,R1J,R2K,R3B),
(ZB,R1J,R2K,R3C),(ZB,R1J,R2K,R3D),(ZB,R1J,R2K,R3E),
(ZB,R1J,R2K,R3F),(ZB,R1J,R2K,R3G),(ZB,R1J,R2K,R3H),
(ZB,R1J,R2K,R3I),(ZB,R1J,R2K,R3J),(ZB,R1J,R2K,R3K),
(ZB,R1J,R2K,R3L),(ZB,R1J,R2K,R3M),(ZB,R1J,R2K,R3N),
(ZB,R1J,R2K,R3O),(ZB,R1J,R2K,R3P),(ZB,R1J,R2K,R3Q),
(ZB,R1J,R2K,R3R),(ZB,R1J,R2L,R3A),(ZB,R1J,R2L,R3B),
(ZB,R1J,R2L,R3C),(ZB,R1J,R2L,R3D),(ZB,R1J,R2L,R3E),
(ZB,R1J,R2L,R3F),(ZB,R1J,R2L,R3G),(ZB,R1J,R2L,R3H),
(ZB,R1J,R2L,R3I),(ZB,R1J,R2L,R3J),(ZB,R1J,R2L,R3K),
(ZB,R1J,R2L,R3L),(ZB,R1J,R2L,R3M),(ZB,R1J,R2L,R3N),
(ZB,R1J,R2L,R3O),(ZB,R1J,R2L,R3P),(ZB,R1J,R2L,R3Q),
(ZB,R1J,R2L,R3R),(ZB,R1J,R2M,R3A),(ZB,R1J,R2M,R3B),
(ZB,R1J,R2M,R3C),(ZB,R1J,R2M,R3D),(ZB,R1J,R2M,R3E),
(ZB,R1J,R2M,R3F),(ZB,R1J,R2M,R3G),(ZB,R1J,R2M,R3H),
(ZB,R1J,R2M,R3I),(ZB,R1J,R2M,R3J),(ZB,R1J,R2M,R3K),
(ZB,R1J,R2M,R3L),(ZB,R1J,R2M,R3M),(ZB,R1J,R2M,R3N),
(ZB,R1J,R2M,R3O),(ZB,R1J,R2M,R3P),(ZB,R1J,R2M,R3Q),
(ZB,R1J,R2M,R3R),(ZB,R1J,R2N,R3A),(ZB,R1J,R2N,R3B),
(ZB,R1J,R2N,R3C),(ZB,R1J,R2N,R3D),(ZB,R1J,R2N,R3E),
(ZB,R1J,R2N,R3F),(ZB,R1J,R2N,R3G),(ZB,R1J,R2N,R3H),
(ZB,R1J,R2N,R3I),(ZB,R1J,R2N,R3J),(ZB,R1J,R2N,R3K),
(ZB,R1J,R2N,R3L),(ZB,R1J,R2N,R3M),(ZB,R1J,R2N,R3N),
(ZB,R1J,R2N,R3O),(ZB,R1J,R2N,R3P),(ZB,R1J,R2N,R3Q),
(ZB,R1J,R2N,R3R),(ZB,R1K,R2A,R3A),(ZB,R1K,R2A,R3B),
(ZB,R1K,R2A,R3C),(ZB,R1K,R2A,R3D),(ZB,R1K,R2A,R3E),
(ZB,R1K,R2A,R3F),(ZB,R1K,R2A,R3G),(ZB,R1K,R2A,R3H),
(ZB,R1K,R2A,R3I),(ZB,R1K,R2A,R3J),(ZB,R1K,R2A,R3K),
(ZB,R1K,R2A,R3L),(ZB,R1K,R2A,R3M),(ZB,R1K,R2A,R3N),
(ZB,R1K,R2A,R3O),(ZB,R1K,R2A,R3P),(ZB,R1K,R2A,R3Q),
(ZB,R1K,R2A,R3R),(ZB,R1K,R2B,R3A),(ZB,R1K,R2B,R3B),
(ZB,R1K,R2B,R3C),(ZB,R1K,R2B,R3D),(ZB,R1K,R2B,R3E),
(ZB,R1K,R2B,R3F),(ZB,R1K,R2B,R3G),(ZB,R1K,R2B,R3H),
(ZB,R1K,R2B,R3I),(ZB,R1K,R2B,R3J),(ZB,R1K,R2B,R3K),
(ZB,R1K,R2B,R3L),(ZB,R1K,R2B,R3M),(ZB,R1K,R2B,R3N),
(ZB,R1K,R2B,R3O),(ZB,R1K,R2B,R3P),(ZB,R1K,R2B,R3Q),
(ZB,R1K,R2B,R3R),(ZB,R1K,R2C,R3A),(ZB,R1K,R2C,R3B),
(ZB,R1K,R2C,R3C),(ZB,R1K,R2C,R3D),(ZB,R1K,R2C,R3E),
(ZB,R1K,R2C,R3F),(ZB,R1K,R2C,R3G),(ZB,R1K,R2C,R3H),
(ZB,R1K,R2C,R3I),(ZB,R1K,R2C,R3J),(ZB,R1K,R2C,R3K),
(ZB,R1K,R2C,R3L),(ZB,R1K,R2C,R3M),(ZB,R1K,R2C,R3N),
(ZB,R1K,R2C,R3O),(ZB,R1K,R2C,R3P),(ZB,R1K,R2C,R3Q),
(ZB,R1K,R2C,R3R),(ZB,R1K,R2D,R3A),(ZB,R1K,R2D,R3B),
(ZB,R1K,R2D,R3C),(ZB,R1K,R2D,R3D),(ZB,R1K,R2D,R3E),
(ZB,R1K,R2D,R3F),(ZB,R1K,R2D,R3G),(ZB,R1K,R2D,R3H),
(ZB,R1K,R2D,R3I),(ZB,R1K,R2D,R3J),(ZB,R1K,R2D,R3K),
(ZB,R1K,R2D,R3L),(ZB,R1K,R2D,R3M),(ZB,R1K,R2D,R3N),
(ZB,R1K,R2D,R3O),(ZB,R1K,R2D,R3P),(ZB,R1K,R2D,R3Q),
(ZB,R1K,R2D,R3R),(ZB,R1K,R2E,R3A),(ZB,R1K,R2E,R3B),
(ZB,R1K,R2E,R3C),(ZB,R1K,R2E,R3D),(ZB,R1K,R2E,R3E),
(ZB,R1K,R2E,R3F),(ZB,R1K,R2E,R3G),(ZB,R1K,R2E,R3H),
(ZB,R1K,R2E,R3I),(ZB,R1K,R2E,R3J),(ZB,R1K,R2E,R3K),
(ZB,R1K,R2E,R3L),(ZB,R1K,R2E,R3M),(ZB,R1K,R2E,R3N),
(ZB,R1K,R2E,R3O),(ZB,R1K,R2E,R3P),(ZB,R1K,R2E,R3Q),
(ZB,R1K,R2E,R3R),(ZB,R1K,R2F,R3A),(ZB,R1K,R2F,R3B),
(ZB,R1K,R2F,R3C),(ZB,R1K,R2F,R3D),(ZB,R1K,R2F,R3E),
(ZB,R1K,R2F,R3F),(ZB,R1K,R2F,R3G),(ZB,R1K,R2F,R3H),
(ZB,R1K,R2F,R3I),(ZB,R1K,R2F,R3J),(ZB,R1K,R2F,R3K),
(ZB,R1K,R2F,R3L),(ZB,R1K,R2F,R3M),(ZB,R1K,R2F,R3N),
(ZB,R1K,R2F,R3O),(ZB,R1K,R2F,R3P),(ZB,R1K,R2F,R3Q),
(ZB,R1K,R2F,R3R),(ZB,R1K,R2G,R3A),(ZB,R1K,R2G,R3B),
(ZB,R1K,R2G,R3C),(ZB,R1K,R2G,R3D),(ZB,R1K,R2G,R3E),
(ZB,R1K,R2G,R3F),(ZB,R1K,R2G,R3G),(ZB,R1K,R2G,R3H),
(ZB,R1K,R2G,R3I),(ZB,R1K,R2G,R3J),(ZB,R1K,R2G,R3K),
(ZB,R1K,R2G,R3L),(ZB,R1K,R2G,R3M),(ZB,R1K,R2G,R3N),
(ZB,R1K,R2G,R3O),(ZB,R1K,R2G,R3P),(ZB,R1K,R2G,R3Q),
(ZB,R1K,R2G,R3R),(ZB,R1K,R2H,R3A),(ZB,R1K,R2H,R3B),
(ZB,R1K,R2H,R3C),(ZB,R1K,R2H,R3D),(ZB,R1K,R2H,R3E),
(ZB,R1K,R2H,R3F),(ZB,R1K,R2H,R3G),(ZB,R1K,R2H,R3H),
(ZB,R1K,R2H,R3I),(ZB,R1K,R2H,R3J),(ZB,R1K,R2H,R3K),
(ZB,R1K,R2H,R3L),(ZB,R1K,R2H,R3M),(ZB,R1K,R2H,R3N),
(ZB,R1K,R2H,R3O),(ZB,R1K,R2H,R3P),(ZB,R1K,R2H,R3Q),
(ZB,R1K,R2H,R3R),(ZB,R1K,R2I,R3A),(ZB,R1K,R2I,R3B),
(ZB,R1K,R2I,R3C),(ZB,R1K,R2I,R3D),(ZB,R1K,R2I,R3E),
(ZB,R1K,R2I,R3F),(ZB,R1K,R2I,R3G),(ZB,R1K,R2I,R3H),
(ZB,R1K,R2I,R3I),(ZB,R1K,R2I,R3J),(ZB,R1K,R2I,R3K),
(ZB,R1K,R2I,R3L),(ZB,R1K,R2I,R3M),(ZB,R1K,R2I,R3N),
(ZB,R1K,R2I,R3O),(ZB,R1K,R2I,R3P),(ZB,R1K,R2I,R3Q),
(ZB,R1K,R2I,R3R),(ZB,R1K,R2J,R3A),(ZB,R1K,R2J,R3B),
(ZB,R1K,R2J,R3C),(ZB,R1K,R2J,R3D),(ZB,R1K,R2J,R3E),
(ZB,R1K,R2J,R3F),(ZB,R1K,R2J,R3G),(ZB,R1K,R2J,R3H),
(ZB,R1K,R2J,R3I),(ZB,R1K,R2J,R3J),(ZB,R1K,R2J,R3K),
(ZB,R1K,R2J,R3L),(ZB,R1K,R2J,R3M),(ZB,R1K,R2J,R3N),
(ZB,R1K,R2J,R3O),(ZB,R1K,R2J,R3P),(ZB,R1K,R2J,R3Q),
(ZB,R1K,R2J,R3R),(ZB,R1K,R2K,R3A),(ZB,R1K,R2K,R3B),
(ZB,R1K,R2K,R3C),(ZB,R1K,R2K,R3D),(ZB,R1K,R2K,R3E),
(ZB,R1K,R2K,R3F),(ZB,R1K,R2K,R3G),(ZB,R1K,R2K,R3H),
(ZB,R1K,R2K,R3I),(ZB,R1K,R2K,R3J),(ZB,R1K,R2K,R3K),
(ZB,R1K,R2K,R3L),(ZB,R1K,R2K,R3M),(ZB,R1K,R2K,R3N),
(ZB,R1K,R2K,R3O),(ZB,R1K,R2K,R3P),(ZB,R1K,R2K,R3Q),
(ZB,R1K,R2K,R3R),(ZB,R1K,R2L,R3A),(ZB,R1K,R2L,R3B),
(ZB,R1K,R2L,R3C),(ZB,R1K,R2L,R3D),(ZB,R1K,R2L,R3E),
(ZB,R1K,R2L,R3F),(ZB,R1K,R2L,R3G),(ZB,R1K,R2L,R3H),
(ZB,R1K,R2L,R3I),(ZB,R1K,R2L,R3J),(ZB,R1K,R2L,R3K),
(ZB,R1K,R2L,R3L),(ZB,R1K,R2L,R3M),(ZB,R1K,R2L,R3N),
(ZB,R1K,R2L,R3O),(ZB,R1K,R2L,R3P),(ZB,R1K,R2L,R3Q),
(ZB,R1K,R2L,R3R),(ZB,R1K,R2M,R3A),(ZB,R1K,R2M,R3B),
(ZB,R1K,R2M,R3C),(ZB,R1K,R2M,R3D),(ZB,R1K,R2M,R3E),
(ZB,R1K,R2M,R3F),(ZB,R1K,R2M,R3G),(ZB,R1K,R2M,R3H),
(ZB,R1K,R2M,R3I),(ZB,R1K,R2M,R3J),(ZB,R1K,R2M,R3K),
(ZB,R1K,R2M,R3L),(ZB,R1K,R2M,R3M),(ZB,R1K,R2M,R3N),
(ZB,R1K,R2M,R3O),(ZB,R1K,R2M,R3P),(ZB,R1K,R2M,R3Q),
(ZB,R1K,R2M,R3R),(ZB,R1K,R2N,R3A),(ZB,R1K,R2N,R3B),
(ZB,R1K,R2N,R3C),(ZB,R1K,R2N,R3D),(ZB,R1K,R2N,R3E),
(ZB,R1K,R2N,R3F),(ZB,R1K,R2N,R3G),(ZB,R1K,R2N,R3H),
(ZB,R1K,R2N,R3I),(ZB,R1K,R2N,R3J),(ZB,R1K,R2N,R3K),
(ZB,R1K,R2N,R3L),(ZB,R1K,R2N,R3M),(ZB,R1K,R2N,R3N),
(ZB,R1K,R2N,R3O),(ZB,R1K,R2N,R3P),(ZB,R1K,R2N,R3Q),
(ZB,R1K,R2N,R3R),(ZB,R1L,R2A,R3A),(ZB,R1L,R2A,R3B),
(ZB,R1L,R2A,R3C),(ZB,R1L,R2A,R3D),(ZB,R1L,R2A,R3E),
(ZB,R1L,R2A,R3F),(ZB,R1L,R2A,R3G),(ZB,R1L,R2A,R3H),
(ZB,R1L,R2A,R3I),(ZB,R1L,R2A,R3J),(ZB,R1L,R2A,R3K),
(ZB,R1L,R2A,R3L),(ZB,R1L,R2A,R3M),(ZB,R1L,R2A,R3N),
(ZB,R1L,R2A,R3O),(ZB,R1L,R2A,R3P),(ZB,R1L,R2A,R3Q),
(ZB,R1L,R2A,R3R),(ZB,R1L,R2B,R3A),(ZB,R1L,R2B,R3B),
(ZB,R1L,R2B,R3C),(ZB,R1L,R2B,R3D),(ZB,R1L,R2B,R3E),
(ZB,R1L,R2B,R3F),(ZB,R1L,R2B,R3G),(ZB,R1L,R2B,R3H),
(ZB,R1L,R2B,R3I),(ZB,R1L,R2B,R3J),(ZB,R1L,R2B,R3K),
(ZB,R1L,R2B,R3L),(ZB,R1L,R2B,R3M),(ZB,r1L,R2B,R3N),
(ZB,R1L,R2B,R3O),(ZB,R1L,R2B,R3P),(ZB,R1L,R2B,R3Q),
(ZB,R1L,R2B,R3R),(ZB,R1L,R2C,R3A),(ZB,R1L,R2C,R3B),
(ZB,R1L,R2C,R3C),(ZB,R1L,R2C,R3D),(ZB,R1L,R2C,R3E),
(ZB,R1L,R2C,R3F),(ZB,R1L,R2C,R3G),(ZB,R1L,R2C,R3H),
(ZB,R1L,R2C,R3I),(ZB,R1L,R2C,R3J),(ZB,R1L,R2C,R3K),
(ZB,R1L,R2C,R3L),(ZB,R1L,R2C,R3M),(ZB,R1L,R2C,R3N),
(ZB,R1L,R2C,R3O),(ZB,R1L,R2C,R3P),(ZB,R1L,R2C,R3Q),
(ZB,R1L,R2C,R3R),(ZB,R1L,R2D,R3A),(ZB,R1L,R2D,R3B),
(ZB,R1L,R2D,R3C),(ZB,R1L,R2D,R3D),(ZB,R1L,R2D,R3E),
(ZB,R1L,R2D,R3F),(ZB,R1L,R2D,R3G),(ZB,R1L,R2D,R3H),
(ZB,R1L,R2D,R3I),(ZB,R1L,R2D,R3J),(ZB,R1L,R2D,R3K),
(ZB,R1L,R2D,R3L),(ZB,R1L,R2D,R3M),(ZB,R1L,R2D,R3N),
(ZB,R1L,R2D,R3O),(ZB,R1L,R2D,R3P),(ZB,R1L,R2D,R3Q),
(ZB,R1L,R2D,R3R),(ZB,R1L,R2E,R3A),(ZB,R1L,R2E,R3B),
(ZB,R1L,R2E,R3C),(ZB,R1L,R2E,R3D),(ZB,R1L,R2E,R3E),
(ZB,R1L,R2E,R3F),(ZB,R1L,R2E,R3G),(ZB,R1L,R2E,R3H),
(ZB,R1L,R2E,R3I),(ZB,R1L,R2E,R3J),(ZB,R1L,R2E,R3K),
(ZB,R1L,R2E,R3L),(ZB,R1L,R2E,R3M),(ZB,R1L,R2E,R3N),
(ZB,R1L,R2E,R3O),(ZB,R1L,R2E,R3P),(ZB,R1L,R2E,R3Q),
(ZB,R1L,R2E,R3R),(ZB,R1L,R2F,R3A),(ZB,R1L,R2F,R3B),
(ZB,R1L,R2F,R3C),(ZB,R1L,R2F,R3D),(ZB,R1L,R2F,R3E),
(ZB,R1L,R2F,R3F),(ZB,R1L,R2F,R3G),(ZB,R1L,R2F,R3H),
(ZB,R1L,R2F,R3I),(ZB,R1L,R2F,R3J),(ZB,R1L,R2F,R3K),
(ZB,R1L,R2F,R3L),(ZB,R1L,R2F,R3M),(ZB,R1L,R2F,R3N),
(ZB,R1L,R2F,R3O),(ZB,R1L,R2F,R3P),(ZB,R1L,R2F,R3Q),
(ZB,R1L,R2F,R3R),(ZB,R1L,R2G,R3A),(ZB,R1L,R2G,R3B),
(ZB,R1L,R2G,R3C),(ZB,R1L,R2G,R3D),(ZB,R1L,R2G,R3E),
(ZB,R1L,R2G,R3F),(ZB,R1L,R2G,R3G),(ZB,R1L,R2G,R3H),
(ZB,R1L,R2G,R3I),(ZB,R1L,R2G,R3J),(ZB,R1L,R2G,R3K),
(ZB,R1L,R2G,R3L),(ZB,R1L,R2G,R3M),(ZB,R1L,R2G,R3N),
(ZB,R1L,R2G,R3O),(ZB,R1L,R2G,R3P),(ZB,R1L,R2G,R3Q),
(ZB,R1L,R2G,R3R),(ZB,R1L,R2H,R3A),(ZB,R1L,R2H,R3B),
(ZB,R1L,R2H,R3C),(ZB,R1L,R2H,R3D),(ZB,R1L,R2H,R3E),
(ZB,R1L,R2H,R3F),(ZB,R1L,R2H,R3G),(ZB,R1L,R2H,R3H),
(ZB,R1L,R2H,R3I),(ZB,R1L,R2H,R3J),(ZB,R1L,R2H,R3K),
(ZB,R1L,R2H,R3L),(ZB,R1L,R2H,R3M),(ZB,R1L,R2H,R3N),
(ZB,R1L,R2H,R3O),(ZB,R1L,R2H,R3P),(ZB,R1L,R2H,R3Q),
(ZB,R1L,R2H,R3R),(ZB,R1L,R2I,R3A),(ZB,R1L,R2I,R3B),
(ZB,R1L,R2I,R3C),(ZB,R1L,R2I,R3D),(ZB,R1L,R2I,R3E),
(ZB,R1L,R2I,R3F),(ZB,R1L,R2I,R3G),(ZB,R1L,R2I,R3H),
(ZB,R1L,R2I,R3I),(ZB,R1L,R2I,R3J),(ZB,R1L,R2I,R3K),
(ZB,R1L,R2I,R3L),(ZB,R1L,R2I,R3M),(ZB,R1L,R2I,R3N),
(ZB,R1L,R2I,R3O),(ZB,R1L,R2I,R3P),(ZB,R1L,R2I,R3Q),
(ZB,R1L,R2I,R3R),(ZB,R1L,R2J,R3A),(ZB,R1L,R2J,R3B),
(ZB,R1L,R2J,R3C),(ZB,R1L,R2J,R3D),(ZB,R1L,R2J,R3E),
(ZB,R1L,R2J,R3F),(ZB,R1L,R2J,R3G),(ZB,R1L,R2J,R3H),
(ZB,R1L,R2J,R3I),(ZB,R1L,R2J,R3J),(ZB,R1L,R2J,R3K),
(ZB,R1L,R2J,R3L),(ZB,R1L,R2J,R3M),(ZB,R1L,R2J,R3N),
(ZB,R1L,R2J,R3O),(ZB,R1L,R2J,R3P),(ZB,R1L,R2J,R3Q),
(ZB,R1L,R2J,R3R),(ZB,R1L,R2K,R3A),(ZB,R1L,R2K,R3B),
(ZB,R1L,R2K,R3C),(ZB,R1L,R2K,R3D),(ZB,R1L,R2K,R3E),
(ZB,R1L,R2K,R3F),(ZB,R1L,R2K,R3G),(ZB,R1L,R2K,R3H),
(ZB,R1L,R2K,R3I),(ZB,R1L,R2K,R3J),(ZB,R1L,R2K,R3K),
(ZB,R1L,R2K,R3L),(ZB,R1L,R2K,R3M),(ZB,R1L,R2K,R3N),
(ZB,R1L,R2K,R3O),(ZB,R1L,R2K,R3P),(ZB,R1L,R2K,R3Q),
(ZB,R1L,R2K,R3R),(ZB,R1L,R2L,R3A),(ZB,R1L,R2L,R3B),
(ZB,R1L,R2L,R3C),(ZB,R1L,R2L,R3D),(ZB,R1L,R2L,R3E),
(ZB,R1L,R2L,R3F),(ZB,R1L,R2L,R3G),(ZB,R1L,R2L,R3H),
(ZB,R1L,R2L,R3I),(ZB,R1L,R2L,R3J),(ZB,R1L,R2L,R3K),
(ZB,R1L,R2L,R3L),(ZB,R1L,R2L,R3M),(ZB,R1L,R2L,R3N),
(ZB,R1L,R2L,R3O),(ZB,R1L,R2L,R3P),(ZB,R1L,R2L,R3Q),
(ZB,R1L,R2L,R3R),(ZB,R1L,R2M,R3A),(ZB,R1L,R2M,R3B),
(ZB,R1L,R2M,R3C),(ZB,R1L,R2M,R3D),(ZB,R1L,R2M,R3E),
(ZB,R1L,R2M,R3F),(ZB,R1L,R2M,R3G),(ZB,R1L,R2M,R3H),
(ZB,R1L,R2M,R3I),(ZB,R1L,R2M,R3J),(ZB,R1L,R2M,R3K),
(ZB,R1L,R2M,R3L),(ZB,R1L,R2M,R3M),(ZB,R1L,R2M,R3N),
(ZB,R1L,R2M,R3O),(ZB,R1L,R2M,R3P),(ZB,R1L,R2M,R3Q),
(ZB,R1L,R2M,R3R),(ZB,R1L,R2N,R3A),(ZB,R1L,R2N,R3B),
(ZB,R1L,R2N,R3C),(ZB,R1L,R2N,R3D),(ZB,R1L,R2N,R3E),
(ZB,R1L,R2N,R3F),(ZB,R1L,R2N,R3G),(ZB,R1L,R2N,R3H),
(ZB,R1L,R2N,R3I),(ZB,R1L,R2N,R3J),(ZB,R1L,R2N,R3K),
(ZB,R1L,R2N,R3L),(ZB,R1L,R2N,R3M),(ZB,R1L,R2N,R3N),
(ZB,R1L,R2N,R3O),(ZB,R1L,R2N,R3P),(ZB,R1L,R2N,R3Q),
(ZB,R1L,R2N,R3R),(ZB,R1M,R2A,R3A),(ZB,R1M,R2A,R3B),
(ZB,R1M,R2A,R3C),(ZB,R1M,R2A,R3D),(ZB,R1M,R2A,R3E),
(ZB,R1M,R2A,R3F),(ZB,R1M,R2A,R3G),(ZB,R1M,R2A,R3H),
(ZB,R1M,R2A,R3I),(ZB,R1M,R2A,R3J),(ZB,R1M,R2A,R3K),
(ZB,R1M,R2A,R3L),(ZB,R1M,R2A,R3M),(ZB,R1M,R2A,R3N),
(ZB,R1M,R2A,R3O),(ZB,R1M,R2A,R3P),(ZB,R1M,R2A,R3Q),
(ZB,R1M,R2A,R3R),(ZB,R1M,R2B,R3A),(ZB,R1M,R2B,R3B),
(ZB,R1M,R2B,R3C),(ZB,R1M,R2B,R3D),(ZB,R1M,R2B,R3E),
(ZB,R1M,R2B,R3F),(ZB,R1M,R2B,R3G),(ZB,R1M,R2B,R3H),
(ZB,R1M,R2B,R3I),(ZB,R1M,R2B,R3J),(ZB,R1M,R2B,R3K),
(ZB,R1M,R2B,R3L),(ZB,R1M,R2B,R3M),(ZB,R1M,R2B,R3N),
(ZB,R1M,R2B,R3O),(ZB,R1M,R2B,R3P),(ZB,R1M,R2B,R3Q),
(ZB,R1M,R2B,R3R),(ZB,R1M,R2C,R3A),(ZB,R1M,R2C,R3B),
(ZB,R1M,R2C,R3C),(ZB,R1M,R2C,R3D),(ZB,R1M,R2C,R3E),
(ZB,R1M,R2C,R3F),(ZB,R1M,R2C,R3G),(ZB,R1M,R2C,R3H),
(ZB,R1M,R2C,R3I),(ZB,R1M,R2C,R3J),(ZB,R1M,R2C,R3K),
(ZB,R1M,R2C,R3L),(ZB,R1M,R2C,R3M),(ZB,R1M,R2C,R3N),
(ZB,R1M,R2C,R3O),(ZB,R1M,R2C,R3P),(ZB,R1M,R2C,R3Q),
(ZB,R1M,R2C,R3R),(ZB,R1M,R2D,R3A),(ZB,R1M,R2D,R3B),
(ZB,R1M,R2D,R3C),(ZB,R1M,R2D,R3D),(ZB,R1M,R2D,R3E),
(ZB,R1M,R2D,R3F),(ZB,R1M,R2D,R3G),(ZB,R1M,R2D,R3H),
(ZB,R1M,R2D,R3I),(ZB,R1M,R2D,R3J),(ZB,R1M,R2D,R3K),
(ZB,R1M,R2D,R3L),(ZB,R1M,R2D,R3M),(ZB,R1M,R2D,R3N),
(ZB,R1M,R2D,R3O),(ZB,R1M,R2D,R3P),(ZB,R1M,R2D,R3Q),
(ZB,R1M,R2D,R3R),(ZB,R1M,R2E,R3A),(ZB,R1M,R2E,R3B),
(ZB,R1M,R2E,R3C),(ZB,R1M,R2E,R3D),(ZB,R1M,R2E,R3E),
(ZB,R1M,R2E,R3F),(ZB,R1M,R2E,R3G),(ZB,R1M,R2E,R3H),
(ZB,R1M,R2E,R3I),(ZB,R1M,R2E,R3J),(ZB,R1M,R2E,R3K),
(ZB,R1M,R2E,R3L),(ZB,R1M,R2E,R3M),(ZB,R1M,R2E,R3N),
(ZB,R1M,R2E,R3O),(ZB,R1M,R2E,R3P),(ZB,R1M,R2E,R3Q),
(ZB,R1M,R2E,R3R),(ZB,R1M,R2F,R3A),(ZB,R1M,R2F,R3B),
(ZB,R1M,R2F,R3C),(ZB,R1M,R2F,R3D),(ZB,R1M,R2F,R3E),
(ZB,R1M,R2F,R3F),(ZB,R1M,R2F,R3G),(ZB,R1M,R2F,R3H),
(ZB,R1M,R2F,R3I),(ZB,R1M,R2F,R3J),(ZB,R1M,R2F,R3K),
(ZB,R1M,R2F,R3L),(ZB,R1M,R2F,R3M),(ZB,R1M,R2F,R3N),
(ZB,R1M,R2F,R3O),(ZB,R1M,R2F,R3P),(ZB,R1M,R2F,R3Q),
(ZB,R1M,R2F,R3R),(ZB,R1M,R2G,R3A),(ZB,R1M,R2G,R3B),
(ZB,R1M,R2G,R3C),(ZB,R1M,R2G,R3D),(ZB,R1M,R2G,R3E),
(ZB,R1M,R2G,R3F),(ZB,R1M,R2G,R3G),(ZB,R1M,R2G,R3H),
(ZB,R1M,R2G,R3I),(ZB,R1M,R2G,R3J),(ZB,R1M,R2G,R3K),
(ZB,R1M,R2G,R3L),(ZB,R1M,R2G,R3M),(ZB,R1M,R2G,R3N),
(ZB,R1M,R2G,R3O),(ZB,R1M,R2G,R3P),(ZB,R1M,R2G,R3Q),
(ZB,R1M,R2G,R3R),(ZB,R1M,R2H,R3A),(ZB,R1M,R2H,R3B),
(ZB,R1M,R2H,R3C),(ZB,R1M,R2H,R3D),(ZB,R1M,R2H,R3E),
(ZB,R1M,R2H,R3F),(ZB,R1M,R2H,R3G),(ZB,R1M,R2H,R3H),
(ZB,R1M,R2H,R3I),(ZB,R1M,R2H,R3J),(ZB,R1M,R2H,R3K),
(ZB,R1M,R2H,R3L),(ZB,R1M,R2H,R3M),(ZB,R1M,R2H,R3N),
(ZB,R1M,R2H,R3O),(ZB,R1M,R2H,R3P),(ZB,R1M,R2H,R3Q),
(ZB,R1M,R2H,R3R),(ZB,R1M,R2I,R3A),(ZB,R1M,R2I,R3B),
(ZB,R1M,R2I,R3C),(ZB,R1M,R2I,R3D),(ZB,R1M,R2I,R3E),
(ZB,R1M,R2I,R3F),(ZB,R1M,R2I,R3G),(ZB,R1M,R2I,R3H),
(ZB,R1M,R2I,R3I),(ZB,R1M,R2I,R3J),(ZB,R1M,R2I,R3K),
(ZB,R1M,R2I,R3L),(ZB,R1M,R2I,R3M),(ZB,R1M,R2I,R3N),
(ZB,R1M,R2I,R3O),(ZB,R1M,R2I,R3P),(ZB,R1M,R2I,R3Q),
(ZB,R1M,R2I,R3R),(ZB,R1M,R2J,R3A),(ZB,R1M,R2J,R3B),
(ZB,R1M,R2J,R3C),(ZB,R1M,R2J,R3D),(ZB,R1M,R2J,R3E),
(ZB,R1M,R2J,R3F),(ZB,R1M,R2J,R3G),(ZB,R1M,R2J,R3H),
(ZB,R1M,R2J,R3I),(ZB,R1M,R2J,R3J),(ZB,R1M,R2J,R3K),
(ZB,R1M,R2J,R3L),(ZB,R1M,R2J,R3M),(ZB,R1M,R2J,R3N),
(ZB,R1M,R2J,R3O),(ZB,R1M,R2J,R3P),(ZB,R1M,R2J,R3Q),
(ZB,R1M,R2J,R3R),(ZB,R1M,R2K,R3A),(ZB,R1M,R2K,R3B),
(ZB,R1M,R2K,R3C),(ZB,R1M,R2K,R3D),(ZB,R1M,R2K,R3E),
(ZB,R1M,R2K,R3F),(ZB,R1M,R2K,R3G),(ZB,R1M,R2K,R3H),
(ZB,R1M,R2K,R3I),(ZB,R1M,R2K,R3J),(ZB,R1M,R2K,R3K),
(ZB,R1M,R2K,R3L),(ZB,R1M,R2K,R3M),(ZB,R1M,R2K,R3N),
(ZB,R1M,R2K,R3O),(ZB,R1M,R2K,R3P),(ZB,R1M,R2K,R3Q),
(ZB,R1M,R2K,R3R),(ZB,R1M,R2L,R3A),(ZB,R1M,R2L,R3B),
(ZB,R1M,R2L,R3C),(ZB,R1M,R2L,R3D),(ZB,R1M,R2L,R3E),
(ZB,R1M,R2L,R3F),(ZB,R1M,R2L,R3G),(ZB,R1M,R2L,R3H),
(ZB,R1M,R2L,R3I),(ZB,R1M,R2L,R3J),(ZB,R1M,R2L,R3K),
(ZB,R1M,R2L,R3L),(ZB,R1M,R2L,R3M),(ZB,R1M,R2L,R3N),
(ZB,R1M,R2L,R3O),(ZB,R1M,R2L,R3P),(ZB,R1M,R2L,R3Q),
(ZB,R1M,R2L,R3R),(ZB,R1M,R2M,R3A),(ZB,R1M,R2M,R3B),
(ZB,R1M,R2M,R3C),(ZB,R1M,R2M,R3D),(ZB,R1M,R2M,R3E),
(ZB,R1M,R2M,R3F),(ZB,R1M,R2M,R3G),(ZB,R1M,R2M,R3H),
(ZB,R1M,R2M,R3I),(ZB,R1M,R2M,R3J),(ZB,R1M,R2M,R3K),
(ZB,R1M,R2M,R3L),(ZB,R1M,R2M,R3M),(ZB,R1M,R2M,R3N),
(ZB,R1M,R2M,R3O),(ZB,R1M,R2M,R3P),(ZB,R1M,R2M,R3Q),
(ZB,R1M,R2M,R3R),(ZB,R1M,R2N,R3A),(ZB,R1M,R2N,R3B),
(ZB,R1M,R2N,R3C),(ZB,R1M,R2N,R3D),(ZB,R1M,R2N,R3E),
(ZB,R1M,R2N,R3F),(ZB,R1M,R2N,R3G),(ZB,R1M,R2N,R3H),
(ZB,R1M,R2N,R3I),(ZB,R1M,R2N,R3J),(ZB,R1M,R2N,R3K),
(ZB,R1M,R2N,R3L),(ZB,R1M,R2N,R3M),(ZB,R1M,R2N,R3N),
(ZB,R1M,R2N,R3O),(ZB,R1M,R2N,R3P),(ZB,R1M,R2N,R3Q),
(ZB,R1M,R2N,R3R),(ZB,R1N,R2A,R3A),(ZB,R1N,R2A,R3B),
(ZB,R1N,R2A,R3C),(ZB,R1N,R2A,R3D),(ZB,R1N,R2A,R3E),
(ZB,R1N,R2A,R3F),(ZB,R1N,R2A,R3G),(ZB,R1N,R2A,R3H),
(ZB,R1N,R2A,R3I),(ZB,R1N,R2A,R3J),(ZB,R1N,R2A,R3K),
(ZB,R1N,R2A,R3L),(ZB,R1N,R2A,R3M),(ZB,R1N,R2A,R3N),
(ZB,R1N,R2A,R3O),(ZB,R1N,R2A,R3P),(ZB,R1N,R2A,R3Q),
(ZB,R1N,R2A,R3R),(ZB,R1N,R2B,R3A),(ZB,R1N,R2B,R3B),
(ZB,R1N,R2B,R3C),(ZB,R1N,R2B,R3D),(ZB,R1N,R2B,R3E),
(ZB,R1N,R2B,R3F),(ZB,R1N,R2B,R3G),(ZB,R1N,R2B,R3H),
(ZB,R1N,R2B,R3I),(ZB,R1N,R2B,R3J),(ZB,R1N,R2B,R3K),
(ZB,R1N,R2B,R3L),(ZB,R1N,R2B,R3M),(ZB,R1N,R2B,R3N),
(ZB,R1N,R2B,R3O),(ZB,R1N,R2B,R3P),(ZB,R1N,R2B,R3Q),
(ZB,R1N,R2B,R3R),(ZB,R1N,R2C,R3A),(ZB,R1N,R2C,R3B),
(ZB,R1N,R2C,R3C),(ZB,R1N,R2C,R3D),(ZB,R1N,R2C,R3E),
(ZB,R1N,R2C,R3F),(ZB,R1N,R2C,R3G),(ZB,R1N,R2C,R3H),
(ZB,R1N,R2C,R3I),(ZB,R1N,R2C,R3J),(ZB,R1N,R2C,R3K),
(ZB,R1N,R2C,R3L),(ZB,R1N,R2C,R3M),(ZB,R1N,R2C,R3N),
(ZB,R1N,R2C,R3O),(ZB,R1N,R2C,R3P),(ZB,R1N,R2C,R3Q),
(ZB,R1N,R2C,R3R),(ZB,R1N,R2D,R3A),(ZB,R1N,R2D,R3B),
(ZB,R1N,R2D,R3C),(ZB,R1N,R2D,R3D),(ZB,R1N,R2D,R3E),
(ZB,R1N,R2D,R3F),(ZB,R1N,R2D,R3G),(ZB,R1N,R2D,R3H),
(ZB,R1N,R2D,R3I),(ZB,R1N,R2D,R3J),(ZB,R1N,R2D,R3K),
(ZB,R1N,R2D,R3L),(ZB,R1N,R2D,R3M),(ZB,R1N,R2D,R3N),
(ZB,R1N,R2D,R3O),(ZB,R1N,R2D,R3P),(ZB,R1N,R2D,R3Q),
(ZB,R1N,R2D,R3R),(ZB,R1N,R2E,R3A),(ZB,R1N,R2E,R3B),
(ZB,R1N,R2E,R3C),(ZB,R1N,R2E,R3D),(ZB,R1N,R2E,R3E),
(ZB,R1N,R2E,R3F),(ZB,R1N,R2E,R3G),(ZB,R1N,R2E,R3H),
(ZB,R1N,R2E,R3I),(ZB,R1N,R2E,R3J),(ZB,R1N,R2E,R3K),
(ZB,R1N,R2E,R3L),(ZB,R1N,R2E,R3M),(ZB,R1N,R2E,R3N),
(ZB,R1N,R2E,R3O),(ZB,R1N,R2E,R3P),(ZB,R1N,R2E,R3Q),
(ZB,R1N,R2E,R3R),(ZB,R1N,R2F,R3A),(ZB,R1N,R2F,R3B),
(ZB,R1N,R2F,R3C),(ZB,R1N,R2F,R3D),(ZB,R1N,R2F,R3E),
(ZB,R1N,R2F,R3F),(ZB,R1N,R2F,R3G),(ZB,R1N,R2F,R3H),
(ZB,R1N,R2F,R3I),(ZB,R1N,R2F,R3J),(ZB,R1N,R2F,R3K),
(ZB,R1N,R2F,R3L),(ZB,R1N,R2F,R3M),(ZB,R1N,R2F,R3N),
(ZB,R1N,R2F,R3O),(ZB,R1N,R2F,R3P),(ZB,R1N,R2F,R3Q),
(ZB,R1N,R2F,R3R),(ZB,R1N,R2G,R3A),(ZB,R1N,R2G,R3B),
(ZB,R1N,R2G,R3C),(ZB,R1N,R2G,R3D),(ZB,R1N,R2G,R3E),
(ZB,R1N,R2G,R3F),(ZB,R1N,R2G,R3G),(ZB,R1N,R2G,R3H),
(ZB,R1N,R2G,R3I),(ZB,R1N,R2G,R3J),(ZB,R1N,R2G,R3K),
(ZB,R1N,R2G,R3L),(ZB,R1N,R2G,R3M),(ZB,R1N,R2G,R3N),
(ZB,R1N,R2G,R3O),(ZB,R1N,R2G,R3P),(ZB,R1N,R2G,R3Q),
(ZB,R1N,R2G,R3R),(ZB,R1N,R2H,R3A),(ZB,R1N,R2H,R3B),
(ZB,R1N,R2H,R3C),(ZB,R1N,R2H,R3D),(ZB,R1N,R2H,R3E),
(ZB,R1N,R2H,R3F),(ZB,R1N,R2H,R3G),(ZB,R1N,R2H,R3H),
(ZB,R1N,R2H,R3I),(ZB,R1N,R2H,R3J),(ZB,R1N,R2H,R3K),
(ZB,R1N,R2H,R3L),(ZB,R1N,R2H,R3M),(ZB,R1N,R2H,R3N),
(ZB,R1N,R2H,R3O),(ZB,R1N,R2H,R3P),(ZB,R1N,R2H,R3Q),
(ZB,R1N,R2H,R3R),(ZB,R1N,R2I,R3A),(ZB,R1N,R2I,R3B),
(ZB,R1N,R2I,R3C),(ZB,R1N,R2I,R3D),(ZB,R1N,R2I,R3E),
(ZB,R1N,R2I,R3F),(ZB,R1N,R2I,R3G),(ZB,R1N,R2I,R3H),
(ZB,R1N,R2I,R3I),(ZB,R1N,R2I,R3J),(ZB,R1N,R2I,R3K),
(ZB,R1N,R2I,R3L),(ZB,R1N,R2I,R3M),(ZB,R1N,R2I,R3N),
(ZB,R1N,R2I,R3O),(ZB,R1N,R2I,R3P),(ZB,R1N,R2I,R3Q),
(ZB,R1N,R2I,R3R),(ZB,R1N,R2J,R3A),(ZB,R1N,R2J,R3B),
(ZB,R1N,R2J,R3C),(ZB,R1N,R2J,R3D),(ZB,R1N,R2J,R3E),
(ZB,R1N,R2J,R3F),(ZB,R1N,R2J,R3G),(ZB,R1N,R2J,R3H),
(ZB,R1N,R2J,R3I),(ZB,R1N,R2J,R3J),(ZB,R1N,R2J,R3K),
(ZB,R1N,R2J,R3L),(ZB,R1N,R2J,R3M),(ZB,R1N,R2J,R3N),
(ZB,R1N,R2J,R3O),(ZB,R1N,R2J,R3P),(ZB,R1N,R2J,R3Q),
(ZB,R1N,R2J,R3R),(ZB,R1N,R2K,R3A),(ZB,R1N,R2K,R3B),
(ZB,R1N,R2K,R3C),(ZB,R1N,R2K,R3D),(ZB,R1N,R2K,R3E),
(ZB,R1N,R2K,R3F),(ZB,R1N,R2K,R3G),(ZB,R1N,R2K,R3H),
(ZB,R1N,R2K,R3I),(ZB,R1N,R2K,R3J),(ZB,R1N,R2K,R3K),
(ZB,R1N,R2K,R3L),(ZB,R1N,R2K,R3M),(ZB,R1N,R2K,R3N),
(ZB,R1N,R2K,R3O),(ZB,R1N,R2K,R3P),(ZB,R1N,R2K,R3Q),
(ZB,R1N,R2K,R3R),(ZB,R1N,R2L,R3A),(ZB,R1N,R2L,R3B),
(ZB,R1N,R2L,R3C),(ZB,R1N,R2L,R3D),(ZB,R1N,R2L,R3E),
(ZB,R1N,R2L,R3F),(ZB,R1N,R2L,R3G),(ZB,R1N,R2L,R3H),
(ZB,R1N,R2L,R3I),(ZB,R1N,R2L,R3J),(ZB,R1N,R2L,R3K),
(ZB,R1N,R2L,R3L),(ZB,R1N,R2L,R3M),(ZB,R1N,R2L,R3N),
(ZB,R1N,R2L,R3O),(ZB,R1N,R2L,R3P),(ZB,R1N,R2L,R3Q),
(ZB,R1N,R2L,R3R),(ZB,R1N,R2M,R3A),(ZB,R1N,R2M,R3B),
(ZB,R1N,R2M,R3C),(ZB,R1N,R2M,R3D),(ZB,R1N,R2M,R3E),
(ZB,R1N,R2M,R3F),(ZB,R1N,R2M,R3G),(ZB,R1N,R2M,R3H),
(ZB,R1N,R2M,R3I),(ZB,R1N,R2M,R3J),(ZB,R1N,R2M,R3K),
(ZB,R1N,R2M,R3L),(ZB,R1N,R2M,R3M),(ZB,R1N,R2M,R3N),
(ZB,R1N,R2M,R3O),(ZB,R1N,R2M,R3P),(ZB,R1N,R2M,R3Q),
(ZB,R1N,R2M,R3R),(ZB,R1N,R2N,R3A),(ZB,R1N,R2N,R3B),
(ZB,R1N,R2N,R3C),(ZB,R1N,R2N,R3D),(ZB,R1N,R2N,R3E),
(ZB,R1N,R2N,R3F),(ZB,R1N,R2N,R3G),(ZB,R1N,R2N,R3H),
(ZB,R1N,R2N,R3I),(ZB,R1N,R2N,R3J),(ZB,R1N,R2N,R3K),
(ZB,R1N,R2N,R3L),(ZB,R1N,R2N,R3M),(ZB,R1N,R2N,R3N),
(ZB,R1N,R2N,R3O),(ZB,R1N,R2N,R3P),(ZB,R1N,R2N,R3Q),
(ZB,R1N,R2N,R3R),(ZB,R1O,R2A,R3A),(ZB,R1O,R2A,R3B),
(ZB,R1O,R2A,R3C),(ZB,R1O,R2A,R3D),(ZB,R1O,R2A,R3E),
(ZB,R1O,R2A,R3F),(ZB,R1O,R2A,R3G),(ZB,R1O,R2A,R3H),
(ZB,R1O,R2A,R3I),(ZB,R1O,R2A,R3J),(ZB,R1O,R2A,R3K),
(ZB,R1O,R2A,R3L),(ZB,R1O,R2A,R3M),(ZB,R1O,R2A,R3N),
(ZB,R1O,R2A,R3O),(ZB,R1O,R2A,R3P),(ZB,R1O,R2A,R3Q),
(ZB,R1O,R2A,R3R),(ZB,R1O,R2B,R3A),(ZB,R1O,R2B,R3B),
(ZB,R1O,R2B,R3C),(ZB,R1O,R2B,R3D),(ZB,R1O,R2B,R3E),
(ZB,R1O,R2B,R3F),(ZB,R1O,R2B,R3G),(ZB,R1O,R2B,R3H),
(ZB,R1O,R2B,R3I),(ZB,R1O,R2B,R3J),(ZB,R1O,R2B,R3K),
(ZB,R1O,R2B,R3L),(ZB,R1O,R2B,R3M),(ZB,R1O,R2B,R3N),
(ZB,R1O,R2B,R3O),(ZB,R1O,R2B,R3P),(ZB,R1O,R2B,R3Q),
(ZB,R1O,R2B,R3R),(ZB,R1O,R2C,R3A),(ZB,R1O,R2C,R3B),
(ZB,R1O,R2C,R3C),(ZB,R1O,R2C,R3D),(ZB,R1O,R2C,R3E),
(ZB,R1O,R2C,R3F),(ZB,R1O,R2C,R3G),(ZB,R1O,R2C,R3H),
(ZB,R1O,R2C,R3I),(ZB,R1O,R2C,R3J),(ZB,R1O,R2C,R3K),
(ZB,R1O,R2C,R3L),(ZB,R1O,R2C,R3M),(ZB,R1O,R2C,R3N),
(ZB,R1O,R2C,R3O),(ZB,R1O,R2C,R3P),(ZB,R1O,R2C,R3Q),
(ZB,R1O,R2C,R3R),(ZB,R1O,R2D,R3A),(ZB,R1O,R2D,R3B),
(ZB,R1O,R2D,R3C),(ZB,R1O,R2D,R3D),(ZB,R1O,R2D,R3E),
(ZB,R1O,R2D,R3F),(ZB,R1O,R2D,R3G),(ZB,R1O,R2D,R3H),
(ZB,R1O,R2D,R3I),(ZB,R1O,R2D,R3J),(ZB,R1O,R2D,R3K),
(ZB,R1O,R2D,R3L),(ZB,R1O,R2D,R3M),(ZB,R1O,R2D,R3N),
(ZB,R1O,R2D,R3O),(ZB,R1O,R2D,R3P),(ZB,R1O,R2D,R3Q),
(ZB,R1O,R2D,R3R),(ZB,R1O,R2E,R3A),(ZB,R1O,R2E,R3B),
(ZB,R1O,R2E,R3C),(ZB,R1O,R2E,R3D),(ZB,R1O,R2E,R3E),
(ZB,R1O,R2E,R3F),(ZB,R1O,R2E,R3G),(ZB,R1O,R2E,R3H),
(ZB,R1O,R2E,R3I),(ZB,R1O,R2E,R3J),(ZB,R1O,R2E,R3K),
(ZB,R1O,R2E,R3L),(ZB,R1O,R2E,R3M),(ZB,R1O,R2E,R3N),
(ZB,R1O,R2E,R3O),(ZB,R1O,R2E,R3P),(ZB,R1O,R2E,R3Q),
(ZB,R1O,R2E,R3R),(ZB,R1O,R2F,R3A),(ZB,R1O,R2F,R3B),
(ZB,R1O,R2F,R3C),(ZB,R1O,R2F,R3D),(ZB,R1O,R2F,R3E),
(ZB,R1O,R2F,R3F),(ZB,R1O,R2F,R3G),(ZB,R1O,R2F,R3H),
(ZB,R1O,R2F,R3I),(ZB,R1O,R2F,R3J),(ZB,R1O,R2F,R3K),
(ZB,R1O,R2F,R3L),(ZB,R1O,R2F,R3M),(ZB,R1O,R2F,R3N),
(ZB,R1O,R2F,R3O),(ZB,R1O,R2F,R3P),(ZB,R1O,R2F,R3Q),
(ZB,R1O,R2F,R3R),(ZB,R1O,R2G,R3A),(ZB,R1O,R2G,R3B),
(ZB,R1O,R2G,R3C),(ZB,R1O,R2G,R3D),(ZB,R1O,R2G,R3E),
(ZB,R1O,R2G,R3F),(ZB,R1O,R2G,R3G),(ZB,R1O,R2G,R3H),
(ZB,R1O,R2G,R3I),(ZB,R1O,R2G,R3J),(ZB,R1O,R2G,R3K),
(ZB,R1O,R2G,R3L),(ZB,R1O,R2G,R3M),(ZB,R1O,R2G,R3N),
(ZB,R1O,R2G,R3O),(ZB,R1O,R2G,R3P),(ZB,R1O,R2G,R3Q),
(ZB,R1O,R2G,R3R),(ZB,R1O,R2H,R3A),(ZB,R1O,R2H,R3B),
(ZB,R1O,R2H,R3C),(ZB,R1O,R2H,R3D),(ZB,R1O,R2H,R3E),
(ZB,R1O,R2H,R3F),(ZB,R1O,R2H,R3G),(ZB,R1O,R2H,R3H),
(ZB,R1O,R2H,R3I),(ZB,R1O,R2H,R3J),(ZB,R1O,R2H,R3K),
(ZB,R1O,R2H,R3L),(ZB,R1O,R2H,R3M),(ZB,R1O,R2H,R3N),
(ZB,R1O,R2H,R3O),(ZB,R1O,R2H,R3P),(ZB,R1O,R2H,R3Q),
(ZB,R1O,R2H,R3R),(ZB,R1O,R2I,R3A),(ZB,R1O,R2I,R3B),
(ZB,R1O,R2I,R3C),(ZB,R1O,R2I,R3D),(ZB,R1O,R2I,R3E),
(ZB,R1O,R2I,R3F),(ZB,R1O,R2I,R3G),(ZB,R1O,R2I,R3H),
(ZB,R1O,R2I,R3I),(ZB,R1O,R2I,R3J),(ZB,R1O,R2I,R3K),
(ZB,R1O,R2I,R3L),(ZB,R1O,R2I,R3M),(ZB,R1O,R2I,R3N),
(ZB,R1O,R2I,R3O),(ZB,R1O,R2I,R3P),(ZB,R1O,R2I,R3Q),
(ZB,R1O,R2I,R3R),(ZB,R1O,R2J,R3A),(ZB,R1O,R2J,R3B),
(ZB,R1O,R2J,R3C),(ZB,R1O,R2J,R3D),(ZB,R1O,R2J,R3E),
(ZB,R1O,R2J,R3F),(ZB,R1O,R2J,R3G),(ZB,R1O,R2J,R3H),
(ZB,R1O,R2J,R3I),(ZB,R1O,R2J,R3J),(ZB,R1O,R2J,R3K),
(ZB,R1O,R2J,R3L),(ZB,R1O,R2J,R3M),(ZB,R1O,R2J,R3N),
(ZB,R1O,R2J,R3O),(ZB,R1O,R2J,R3P),(ZB,R1O,R2J,R3Q),
(ZB,R1O,R2J,R3R),(ZB,R1O,R2K,R3A),(ZB,R1O,R2K,R3B),
(ZB,R1O,R2K,R3C),(ZB,R1O,R2K,R3D),(ZB,R1O,R2K,R3E),
(ZB,R1O,R2K,R3F),(ZB,R1O,R2K,R3G),(ZB,R1O,R2K,R3H),
(ZB,R1O,R2K,R3I),(ZB,R1O,R2K,R3J),(ZB,R1O,R2K,R3K),
(ZB,R1O,R2K,R3L),(ZB,R1O,R2K,R3M),(ZB,R1O,R2K,R3N),
(ZB,R1O,R2K,R3O),(ZB,R1O,R2K,R3P),(ZB,R1O,R2K,R3Q),
(ZB,R1O,R2K,R3R),(ZB,R1O,R2L,R3A),(ZB,R1O,R2L,R3B),
(ZB,R1O,R2L,R3C),(ZB,R1O,R2L,R3D),(ZB,R1O,R2L,R3E),
(ZB,R1O,R2L,R3F),(ZB,R1O,R2L,R3G),(ZB,R1O,R2L,R3H),
(ZB,R1O,R2L,R3I),(ZB,R1O,R2L,R3J),(ZB,R1O,R2L,R3K),
(ZB,R1O,R2L,R3L),(ZB,R1O,R2L,R3M),(ZB,R1O,R2L,R3N),
(ZB,R1O,R2L,R3O),(ZB,R1O,R2L,R3P),(ZB,R1O,R2L,R3Q),
(ZB,R1O,R2L,R3R),(ZB,R1O,R2M,R3A),(ZB,R1O,R2M,R3B),
(ZB,R1O,R2M,R3C),(ZB,R1O,R2M,R3D),(ZB,R1O,R2M,R3E),
(ZB,R1O,R2M,R3F),(ZB,R1O,R2M,R3G),(ZB,R1O,R2M,R3H),
(ZB,R1O,R2M,R3I),(ZB,R1O,R2M,R3J),(ZB,R1O,R2M,R3K),
(ZB,R1O,R2M,R3L),(ZB,R1O,R2M,R3M),(ZB,R1O,R2M,R3N),
(ZB,R1O,R2M,R3O),(ZB,R1O,R2M,R3P),(ZB,R1O,R2M,R3Q),
(ZB,R1O,R2M,R3R),(ZB,R1O,R2N,R3A),(ZB,R1O,R2N,R3B),
(ZB,R1O,R2N,R3C),(ZB,R1O,R2N,R3D),(ZB,R1O,R2N,R3E),
(ZB,R1O,R2N,R3F),(ZB,R1O,R2N,R3G),(ZB,R1O,R2N,R3H),
(ZB,R1O,R2N,R3I),(ZB,R1O,R2N,R3J),(ZB,R1O,R2N,R3K),
(ZB,R1O,R2N,R3L),(ZB,R1O,R2N,R3M),(ZB,R1O,R2N,R3N),
(ZB,R1O,R2N,R3O),(ZB,R1O,R2N,R3P),(ZB,R1O,R2N,R3Q),
(ZB,R1O,R2N,R3R),(ZB,R1P,R2A,R3A),(ZB,R1P,R2A,R3B),
(ZB,R1P,R2A,R3C),(ZB,R1P,R2A,R3D),(ZB,R1P,R2A,R3E),
(ZB,R1P,R2A,R3F),(ZB,R1P,R2A,R3G),(ZB,R1P,R2A,R3H),
(ZB,R1P,R2A,R3I),(ZB,R1P,R2A,R3J),(ZB,R1P,R2A,R3K),
(ZB,R1P,R2A,R3L),(ZB,R1P,R2A,R3M),(ZB,R1P,R2A,R3N),
(ZB,R1P,R2A,R3O),(ZB,R1P,R2A,R3P),(ZB,R1P,R2A,R3Q),
(ZB,R1P,R2A,R3R),(ZB,R1P,R2B,R3A),(ZB,R1P,R2B,R3B),
(ZB,R1P,R2B,R3C),(ZB,R1P,R2B,R3D),(ZB,R1P,R2B,R3E),
(ZB,R1P,R2B,R3F),(ZB,R1P,R2B,R3G),(ZB,R1P,R2B,R3H),
(ZB,R1P,R2B,R3I),(ZB,R1P,R2B,R3J),(ZB,R1P,R2B,R3K),
(ZB,R1P,R2B,R3L),(ZB,R1P,R2B,R3M),(ZB,R1P,R2B,R3N),
(ZB,R1P,R2B,R3O),(ZB,R1P,R2B,R3P),(ZB,R1P,R2B,R3Q),
(ZB,R1P,R2B,R3R),(ZB,R1P,R2C,R3A),(ZB,R1P,R2C,R3B),
(ZB,R1P,R2C,R3C),(ZB,R1P,R2C,R3D),(ZB,R1P,R2C,R3E),
(ZB,R1P,R2C,R3F),(ZB,R1P,R2C,R3G),(ZB,R1P,R2C,R3H),
(ZB,R1P,R2C,R3I),(ZB,R1P,R2C,R3J),(ZB,R1P,R2C,R3K),
(ZB,R1P,R2C,R3L),(ZB,R1P,R2C,R3M),(ZB,R1P,R2C,R3N),
(ZB,R1P,R2C,R3O),(ZB,R1P,R2C,R3P),(ZB,R1P,R2C,R3Q),
(ZB,R1P,R2C,R3R),(ZB,R1P,R2D,R3A),(ZB,R1P,R2D,R3B),
(ZB,R1P,R2D,R3C),(ZB,R1P,R2D,R3D),(ZB,R1P,R2D,R3E),
(ZB,R1P,R2D,R3F),(ZB,R1P,R2D,R3G),(ZB,R1P,R2D,R3H),
(ZB,R1P,R2D,R3I),(ZB,R1P,R2D,R3J),(ZB,R1P,R2D,R3K),
(ZB,R1P,R2D,R3L),(ZB,R1P,R2D,R3M),(ZB,R1P,R2D,R3N),
(ZB,R1P,R2D,R3O),(ZB,R1P,R2D,R3P),(ZB,R1P,R2D,R3Q),
(ZB,R1P,R2D,R3R),(ZB,R1P,R2E,R3A),(ZB,R1P,R2E,R3B),
(ZB,R1P,R2E,R3C),(ZB,R1P,R2E,R3D),(ZB,R1P,R2E,R3E),
(ZB,R1P,R2E,R3F),(ZB,R1P,R2E,R3G),(ZB,R1P,R2E,R3H),
(ZB,R1P,R2E,R3I),(ZB,R1P,R2E,R3J),(ZB,R1P,R2E,R3K),
(ZB,R1P,R2E,R3L),(ZB,R1P,R2E,R3M),(ZB,R1P,R2E,R3N),
(ZB,R1P,R2E,R3O),(ZB,R1P,R2E,R3P),(ZB,R1P,R2E,R3Q),
(ZB,R1P,R2E,R3R),(ZB,R1P,R2F,R3A),(ZB,R1P,R2F,R3B),
(ZB,R1P,R2F,R3C),(ZB,R1P,R2F,R3D),(ZB,R1P,R2F,R3E),
(ZB,R1P,R2F,R3F),(ZB,R1P,R2F,R3G),(ZB,R1P,R2F,R3H),
(ZB,R1P,R2F,R3I),(ZB,R1P,R2F,R3J),(ZB,R1P,R2F,R3K),
(ZB,R1P,R2F,R3L),(ZB,R1P,R2F,R3M),(ZB,R1P,R2F,R3N),
(ZB,R1P,R2F,R3O),(ZB,R1P,R2F,R3P),(ZB,R1P,R2F,R3Q),
(ZB,R1P,R2F,R3R),(ZB,R1P,R2G,R3A),(ZB,R1P,R2G,R3B),
(ZB,R1P,R2G,R3C),(ZB,R1P,R2G,R3D),(ZB,R1P,R2G,R3E),
(ZB,R1P,R2G,R3F),(ZB,R1P,R2G,R3G),(ZB,R1P,R2G,R3H),
(ZB,R1P,R2G,R3I),(ZB,R1P,R2G,R3J),(ZB,R1P,R2G,R3K),
(ZB,R1P,R2G,R3L),(ZB,R1P,R2G,R3M),(ZB,R1P,R2G,R3N),
(ZB,R1P,R2G,R3O),(ZB,R1P,R2G,R3P),(ZB,R1P,R2G,R3Q),
(ZB,R1P,R2G,R3R),(ZB,R1P,R2H,R3A),(ZB,R1P,R2H,R3B),
(ZB,R1P,R2H,R3C),(ZB,R1P,R2H,R3D),(ZB,R1P,R2H,R3E),
(ZB,R1P,R2H,R3F),(ZB,R1P,R2H,R3G),(ZB,R1P,R2H,R3H),
(ZB,R1P,R2H,R3I),(ZB,R1P,R2H,R3J),(ZB,R1P,R2H,R3K),
(ZB,R1P,R2H,R3L),(ZB,R1P,R2H,R3M),(ZB,R1P,R2H,R3N),
(ZB,R1P,R2H,R3O),(ZB,R1P,R2H,R3P),(ZB,R1P,R2H,R3Q),
(ZB,R1P,R2H,R3R),(ZB,R1P,R2I,R3A),(ZB,R1P,R2I,R3B),
(ZB,R1P,R2I,R3C),(ZB,R1P,R2I,R3D),(ZB,R1P,R2I,R3E),
(ZB,R1P,R2I,R3F),(ZB,R1P,R2I,R3G),(ZB,R1P,R2I,R3H),
(ZB,R1P,R2I,R3I),(ZB,R1P,R2I,R3J),(ZB,R1P,R2I,R3K),
(ZB,R1P,R2I,R3L),(ZB,R1P,R2I,R3M),(ZB,R1P,R2I,R3N),
(ZB,R1P,R2I,R3O),(ZB,R1P,R2I,R3P),(ZB,R1P,R2I,R3Q),
(ZB,R1P,R2I,R3R),(ZB,R1P,R2J,R3A),(ZB,R1P,R2J,R3B),
(ZB,R1P,R2J,R3C),(ZB,R1P,R2J,R3D),(ZB,R1P,R2J,R3E),
(ZB,R1P,R2J,R3F),(ZB,R1P,R2J,R3G),(ZB,R1P,R2J,R3H),
(ZB,R1P,R2J,R3I),(ZB,R1P,R2J,R3J),(ZB,R1P,R2J,R3K),
(ZB,R1P,R2J,R3L),(ZB,R1P,R2J,R3M),(ZB,R1P,R2J,R3N),
(ZB,R1P,R2J,R3O),(ZB,R1P,R2J,R3P),(ZB,R1P,R2J,R3Q),
(ZB,R1P,R2J,R3R),(ZB,R1P,R2K,R3A),(ZB,R1P,R2K,R3B),
(ZB,R1P,R2K,R3C),(ZB,R1P,R2K,R3D),(ZB,R1P,R2K,R3E),
(ZB,R1P,R2K,R3F),(ZB,R1P,R2K,R3G),(ZB,R1P,R2K,R3H),
(ZB,R1P,R2K,R3I),(ZB,R1P,R2K,R3J),(ZB,R1P,R2K,R3K),
(ZB,R1P,R2K,R3L),(ZB,R1P,R2K,R3M),(ZB,R1P,R2K,R3N),
(ZB,R1P,R2K,R3O),(ZB,R1P,R2K,R3P),(ZB,R1P,R2K,R3Q),
(ZB,R1P,R2K,R3R),(ZB,R1P,R2L,R3A),(ZB,R1P,R2L,R3B),
(ZB,R1P,R2L,R3C),(ZB,R1P,R2L,R3D),(ZB,R1P,R2L,R3E),
(ZB,R1P,R2L,R3F),(ZB,R1P,R2L,R3G),(ZB,R1P,R2L,R3H),
(ZB,R1P,R2L,R3I),(ZB,R1P,R2L,R3J),(ZB,R1P,R2L,R3K),
(ZB,R1P,R2L,R3L),(ZB,R1P,R2L,R3M),(ZB,R1P,R2L,R3N),
(ZB,R1P,R2L,R3O),(ZB,R1P,R2L,R3P),(ZB,R1P,R2L,R3Q),
(ZB,R1P,R2L,R3R),(ZB,R1P,R2M,R3A),(ZB,R1P,R2M,R3B),
(ZB,R1P,R2M,R3C),(ZB,R1P,R2M,R3D),(ZB,R1P,R2M,R3E),
(ZB,R1P,R2M,R3F),(ZB,R1P,R2M,R3G),(ZB,R1P,R2M,R3H),
(ZB,R1P,R2M,R3I),(ZB,R1P,R2M,R3J),(ZB,R1P,R2M,R3K),
(ZB,R1P,R2M,R3L),(ZB,R1P,R2M,R3M),(ZB,R1P,R2M,R3N),
(ZB,R1P,R2M,R3O),(ZB,R1P,R2M,R3P),(ZB,R1P,R2M,R3Q),
(ZB,R1P,R2M,R3R),(ZB,R1P,R2N,R3A),(ZB,R1P,R2N,R3B),
(ZB,R1P,R2N,R3C),(ZB,R1P,R2N,R3D),(ZB,R1P,R2N,R3E),
(ZB,R1P,R2N,R3F),(ZB,R1P,R2N,R3G),(ZB,R1P,R2N,R3H),
(ZB,R1P,R2N,R3I),(ZB,R1P,R2N,R3J),(ZB,R1P,R2N,R3K),
(ZB,R1P,R2N,R3L),(ZB,R1P,R2N,R3M),(ZB,R1P,R2N,R3N),
(ZB,R1P,R2N,R3O),(ZB,R1P,R2N,R3P),(ZB,R1P,R2N,R3Q),
(ZB,R1P,R2N,R3R),(ZB,R1Q,R2A,R3A),(ZB,R1Q,R2A,R3B),
(ZB,R1Q,R2A,R3C),(ZB,R1Q,R2A,R3D),(ZB,R1Q,R2A,R3E),
(ZB,R1Q,R2A,R3F),(ZB,R1Q,R2A,R3G),(ZB,R1Q,R2A,R3H),
(ZB,R1Q,R2A,R3I),(ZB,R1Q,R2A,R3J),(ZB,R1Q,R2A,R3K),
(ZB,R1Q,R2A,R3L),(ZB,R1Q,R2A,R3M),(ZB,R1Q,R2A,R3N),
(ZB,R1Q,R2A,R3O),(ZB,R1Q,R2A,R3P),(ZB,R1Q,R2A,R3Q),
(ZB,R1Q,R2A,R3R),(ZB,R1Q,R2B,R3A),(ZB,R1Q,R2B,R3B),
(ZB,R1Q,R2B,R3C),(ZB,R1Q,R2B,R3D),(ZB,R1Q,R2B,R3E),
(ZB,R1Q,R2B,R3F),(ZB,R1Q,R2B,R3G),(ZB,R1Q,R2B,R3H),
(ZB,R1Q,R2B,R3I),(ZB,R1Q,R2B,R3J),(ZB,R1Q,R2B,R3K),
(ZB,R1Q,R2B,R3L),(ZB,R1Q,R2B,R3M),(ZB,R1Q,R2B,R3N),
(ZB,R1Q,R2B,R3O),(ZB,R1Q,R2B,R3P),(ZB,R1Q,R2B,R3Q),
(ZB,R1Q,R2B,R3R),(ZB,R1Q,R2C,R3A),(ZB,R1Q,R2C,R3B),
(ZB,R1Q,R2C,R3C),(ZB,R1Q,R2C,R3D),(ZB,R1Q,R2C,R3E),
(ZB,R1Q,R2C,R3F),(ZB,R1Q,R2C,R3G),(ZB,R1Q,R2C,R3H),
(ZB,R1Q,R2C,R3I),(ZB,R1Q,R2C,R3J),(ZB,R1Q,R2C,R3K),
(ZB,R1Q,R2C,R3L),(ZB,R1Q,R2C,R3M),(ZB,R1Q,R2C,R3N),
(ZB,R1Q,R2C,R3O),(ZB,R1Q,R2C,R3P),(ZB,R1Q,R2C,R3Q),
(ZB,R1Q,R2C,R3R),(ZB,R1Q,R2D,R3A),(ZB,R1Q,R2D,R3B),
(ZB,R1Q,R2D,R3C),(ZB,R1Q,R2D,R3D),(ZB,R1Q,R2D,R3E),
(ZB,R1Q,R2D,R3F),(ZB,R1Q,R2D,R3G),(ZB,R1Q,R2D,R3H),
(ZB,R1Q,R2D,R3I),(ZB,R1Q,R2D,R3J),(ZB,R1Q,R2D,R3K),
(ZB,R1Q,R2D,R3L),(ZB,R1Q,R2D,R3M),(ZB,R1Q,R2D,R3N),
(ZB,R1Q,R2D,R3O),(ZB,R1Q,R2D,R3P),(ZB,R1Q,R2D,R3Q),
(ZB,R1Q,R2D,R3R),(ZB,R1Q,R2E,R3A),(ZB,R1Q,R2E,R3B),
(ZB,R1Q,R2E,R3C),(ZB,R1Q,R2E,R3D),(ZB,R1Q,R2E,R3E),
(ZB,R1Q,R2E,R3F),(ZB,R1Q,R2E,R3G),(ZB,R1Q,R2E,R3H),
(ZB,R1Q,R2E,R3I),(ZB,R1Q,R2E,R3J),(ZB,R1Q,R2E,R3K),
(ZB,R1Q,R2E,R3L),(ZB,R1Q,R2E,R3M),(ZB,R1Q,R2E,R3N),
(ZB,R1Q,R2E,R3O),(ZB,R1Q,R2E,R3P),(ZB,R1Q,R2E,R3Q),
(ZB,R1Q,R2E,R3R),(ZB,R1Q,R2F,R3A),(ZB,R1Q,R2F,R3B),
(ZB,R1Q,R2F,R3C),(ZB,R1Q,R2F,R3D),(ZB,R1Q,R2F,R3E),
(ZB,R1Q,R2F,R3F),(ZB,R1Q,R2F,R3G),(ZB,R1Q,R2F,R3H),
(ZB,R1Q,R2F,R3I),(ZB,R1Q,R2F,R3J),(ZB,R1Q,R2F,R3K),
(ZB,R1Q,R2F,R3L),(ZB,R1Q,R2F,R3M),(ZB,R1Q,R2F,R3N),
(ZB,R1Q,R2F,R3O),(ZB,R1Q,R2F,R3P),(ZB,R1Q,R2F,R3Q),
(ZB,R1Q,R2F,R3R),(ZB,R1Q,R2G,R3A),(ZB,R1Q,R2G,R3B),
(ZB,R1Q,R2G,R3C),(ZB,R1Q,R2G,R3D),(ZB,R1Q,R2G,R3E),
(ZB,R1Q,R2G,R3F),(ZB,R1Q,R2G,R3G),(ZB,R1Q,R2G,R3H),
(ZB,R1Q,R2G,R3I),(ZB,R1Q,R2G,R3J),(ZB,R1Q,R2G,R3K),
(ZB,R1Q,R2G,R3L),(ZB,R1Q,R2G,R3M),(ZB,R1Q,R2G,R3N),
(ZB,R1Q,R2G,R3O),(ZB,R1Q,R2G,R3P),(ZB,R1Q,R2G,R3Q),
(ZB,R1Q,R2G,R3R),(ZB,R1Q,R2H,R3A),(ZB,R1Q,R2H,R3B),
(ZB,R1Q,R2H,R3C),(ZB,R1Q,R2H,R3D),(ZB,R1Q,R2H,R3E),
(ZB,R1Q,R2H,R3F),(ZB,R1Q,R2H,R3G),(ZB,R1Q,R2H,R3H),
(ZB,R1Q,R2H,R3I),(ZB,R1Q,R2H,R3J),(ZB,R1Q,R2H,R3K),
(ZB,R1Q,R2H,R3L),(ZB,R1Q,R2H,R3M),(ZB,R1Q,R2H,R3N),
(ZB,R1Q,R2H,R3O),(ZB,R1Q,R2H,R3P),(ZB,R1Q,R2H,R3Q),
(ZB,R1Q,R2H,R3R),(ZB,R1Q,R2I,R3A),(ZB,R1Q,R2I,R3B),
(ZB,R1Q,R2I,R3C),(ZB,R1Q,R2I,R3D),(ZB,R1Q,R2I,R3E),
(ZB,R1Q,R2I,R3F),(ZB,R1Q,R2I,R3G),(ZB,R1Q,R2I,R3H),
(ZB,R1Q,R2I,R3I),(ZB,R1Q,R2I,R3J),(ZB,R1Q,R2I,R3K),
(ZB,R1Q,R2I,R3L),(ZB,R1Q,R2I,R3M),(ZB,R1Q,R2I,R3N),
(ZB,R1Q,R2I,R3O),(ZB,R1Q,R2I,R3P),(ZB,R1Q,R2I,R3Q),
(ZB,R1Q,R2I,R3R),(ZB,R1Q,R2J,R3A),(ZB,R1Q,R2J,R3B),
(ZB,R1Q,R2J,R3C),(ZB,R1Q,R2J,R3D),(ZB,R1Q,R2J,R3E),
(ZB,R1Q,R2J,R3F),(ZB,R1Q,R2J,R3G),(ZB,R1Q,R2J,R3H),
(ZB,R1Q,R2J,R3I),(ZB,R1Q,R2J,R3J),(ZB,R1Q,R2J,R3K),
(ZB,R1Q,R2J,R3L),(ZB,R1Q,R2J,R3M),(ZB,R1Q,R2J,R3N),
(ZB,R1Q,R2J,R3O),(ZB,R1Q,R2J,R3P),(ZB,R1Q,R2J,R3Q),
(ZB,R1Q,R2J,R3R),(ZB,R1Q,R2K,R3A),(ZB,R1Q,R2K,R3B),
(ZB,R1Q,R2K,R3C),(ZB,R1Q,R2K,R3D),(ZB,R1Q,R2K,R3E),
(ZB,R1Q,R2K,R3F),(ZB,R1Q,R2K,R3G),(ZB,R1Q,R2K,R3H),
(ZB,R1Q,R2K,R3I),(ZB,R1Q,R2K,R3J),(ZB,R1Q,R2K,R3K),
(ZB,R1Q,R2K,R3L),(ZB,R1Q,R2K,R3M),(ZB,R1Q,R2K,R3N),
(ZB,R1Q,R2K,R3O),(ZB,R1Q,R2K,R3P),(ZB,R1Q,R2K,R3Q),
(ZB,R1Q,R2K,R3R),(ZB,R1Q,R2L,R3A),(ZB,R1Q,R2L,R3B),
(ZB,R1Q,R2L,R3C),(ZB,R1Q,R2L,R3D),(ZB,R1Q,R2L,R3E),
(ZB,R1Q,R2L,R3F),(ZB,R1Q,R2L,R3G),(ZB,R1Q,R2L,R3H),
(ZB,R1Q,R2L,R3I),(ZB,R1Q,R2L,R3J),(ZB,R1Q,R2L,R3K),
(ZB,R1Q,R2L,R3L),(ZB,R1Q,R2L,R3M),(ZB,R1Q,R2L,R3N),
(ZB,R1Q,R2L,R3O),(ZB,R1Q,R2L,R3P),(ZB,R1Q,R2L,R3Q),
(ZB,R1Q,R2L,R3R),(ZB,R1Q,R2M,R3A),(ZB,R1Q,R2M,R3B),
(ZB,R1Q,R2M,R3C),(ZB,R1Q,R2M,R3D),(ZB,R1Q,R2M,R3E),
(ZB,R1Q,R2M,R3F),(ZB,R1Q,R2M,R3G),(ZB,R1Q,R2M,R3H),
(ZB,R1Q,R2M,R3I),(ZB,R1Q,R2M,R3J),(ZB,R1Q,R2M,R3K),
(ZB,R1Q,R2M,R3L),(ZB,R1Q,R2M,R3M),(ZB,R1Q,R2M,R3N),
(ZB,R1Q,R2M,R3O),(ZB,R1Q,R2M,R3P),(ZB,R1Q,R2M,R3Q),
(ZB,R1Q,R2M,R3R),(ZB,R1Q,R2N,R3A),(ZB,R1Q,R2N,R3B),
(ZB,R1Q,R2N,R3C),(ZB,R1Q,R2N,R3D),(ZB,R1Q,R2N,R3E),
(ZB,R1Q,R2N,R3F),(ZB,R1Q,R2N,R3G),(ZB,R1Q,R2N,R3H),
(ZB,R1Q,R2N,R3I),(ZB,R1Q,R2N,R3J),(ZB,R1Q,R2N,R3K),
(ZB,R1Q,R2N,R3L),(ZB,R1Q,R2N,R3M),(ZB,R1Q,R2N,R3N),
(ZB,R1Q,R2N,R3O),(ZB,R1Q,R2N,R3P),(ZB,R1Q,R2N,R3Q),
(ZB,R1Q,R2N,R3R),(ZB,R1R,R2A,R3A),(ZB,R1R,R2A,R3B),
(ZB,R1R,R2A,R3C),(ZB,R1R,R2A,R3D),(ZB,R1R,R2A,R3E),
(ZB,R1R,R2A,R3F),(ZB,R1R,R2A,R3G),(ZB,R1R,R2A,R3H),
(ZB,R1R,R2A,R3I),(ZB,R1R,R2A,R3J),(ZB,R1R,R2A,R3K),
(ZB,R1R,R2A,R3L),(ZB,R1R,R2A,R3M),(ZB,R1R,R2A,R3N),
(ZB,R1R,R2A,R3O),(ZB,R1R,R2A,R3P),(ZB,R1R,R2A,R3Q),
(ZB,R1R,R2A,R3R),(ZB,R1R,R2B,R3A),(ZB,R1R,R2B,R3B),
(ZB,R1R,R2B,R3C),(ZB,R1R,R2B,R3D),(ZB,R1R,R2B,R3E),
(ZB,R1R,R2B,R3F),(ZB,R1R,R2B,R3G),(ZB,R1R,R2B,R3H),
(ZB,R1R,R2B,R3I),(ZB,R1R,R2B,R3J),(ZB,R1R,R2B,R3K),
(ZB,R1R,R2B,R3L),(ZB,R1R,R2B,R3M),(ZB,R1R,R2B,R3N),
(ZB,R1R,R2B,R3O),(ZB,R1R,R2B,R3P),(ZB,R1R,R2B,R3Q),
(ZB,R1R,R2B,R3R),(ZB,R1R,R2C,R3A),(ZB,R1R,R2C,R3B),
(ZB,R1R,R2C,R3C),(ZB,R1R,R2C,R3D),(ZB,R1R,R2C,R3E),
(ZB,R1R,R2C,R3F),(ZB,R1R,R2C,R3G),(ZB,R1R,R2C,R3H),
(ZB,R1R,R2C,R3I),(ZB,R1R,R2C,R3J),(ZB,R1R,R2C,R3K),
(ZB,R1R,R2C,R3L),(ZB,R1R,R2C,R3M),(ZB,R1R,R2C,R3N),
(ZB,R1R,R2C,R3O),(ZB,R1R,R2C,R3P),(ZB,R1R,R2C,R3Q),
(ZB,R1R,R2C,R3R),(ZB,R1R,R2D,R3A),(ZB,R1R,R2D,R3B),
(ZB,R1R,R2D,R3C),(ZB,R1R,R2D,R3D),(ZB,R1R,R2D,R3E),
(ZB,R1R,R2D,R3F),(ZB,R1R,R2D,R3G),(ZB,R1R,R2D,R3H),
(ZB,R1R,R2D,R3I),(ZB,R1R,R2D,R3J),(ZB,R1R,R2D,R3K),
(ZB,R1R,R2D,R3L),(ZB,R1R,R2D,R3M),(ZB,R1R,R2D,R3N),
(ZB,R1R,R2D,R3O),(ZB,R1R,R2D,R3P),(ZB,R1R,R2D,R3Q),
(ZB,R1R,R2D,R3R),(ZB,R1R,R2E,R3A),(ZB,R1R,R2E,R3B),
(ZB,R1R,R2E,R3C),(ZB,R1R,R2E,R3D),(ZB,R1R,R2E,R3E),
(ZB,R1R,R2E,R3F),(ZB,R1R,R2E,R3G),(ZB,R1R,R2E,R3H),
(ZB,R1R,R2E,R3I),(ZB,R1R,R2E,R3J),(ZB,R1R,R2E,R3K),
(ZB,R1R,R2E,R3L),(ZB,R1R,R2E,R3M),(ZB,R1R,R2E,R3N),
(ZB,R1R,R2E,R3O),(ZB,R1R,R2E,R3P),(ZB,R1R,R2E,R3Q),
(ZB,R1R,R2E,R3R),(ZB,R1R,R2F,R3A),(ZB,R1R,R2F,R3B),
(ZB,R1R,R2F,R3C),(ZB,R1R,R2F,R3D),(ZB,R1R,R2F,R3E),
(ZB,R1R,R2F,R3F),(ZB,R1R,R2F,R3G),(ZB,R1R,R2F,R3H),
(ZB,R1R,R2F,R3I),(ZB,R1R,R2F,R3J),(ZB,R1R,R2F,R3K),
(ZB,R1R,R2F,R3L),(ZB,R1R,R2F,R3M),(ZB,R1R,R2F,R3N),
(ZB,R1R,R2F,R3O),(ZB,R1R,R2F,R3P),(ZB,R1R,R2F,R3Q),
(ZB,R1R,R2F,R3R),(ZB,R1R,R2G,R3A),(ZB,R1R,R2G,R3B),
(ZB,R1R,R2G,R3C),(ZB,R1R,R2G,R3D),(ZB,R1R,R2G,R3E),
(ZB,R1R,R2G,R3F),(ZB,R1R,R2G,R3G),(ZB,R1R,R2G,R3H),
(ZB,R1R,R2G,R3I),(ZB,R1R,R2G,R3J),(ZB,R1R,R2G,R3K),
(ZB,R1R,R2G,R3L),(ZB,R1R,R2G,R3M),(ZB,R1R,R2G,R3N),
(ZB,R1R,R2G,R3O),(ZB,R1R,R2G,R3P),(ZB,R1R,R2G,R3Q),
(ZB,R1R,R2G,R3R),(ZB,R1R,R2H,R3A),(ZB,R1R,R2H,R3B),
(ZB,R1R,R2H,R3C),(ZB,R1R,R2H,R3D),(ZB,R1R,R2H,R3E),
(ZB,R1R,R2H,R3F),(ZB,R1R,R2H,R3G),(ZB,R1R,R2H,R3H),
(ZB,R1R,R2H,R3I),(ZB,R1R,R2H,R3J),(ZB,R1R,R2H,R3K),
(ZB,R1R,R2H,R3L),(ZB,R1R,R2H,R3M),(ZB,R1R,R2H,R3N),
(ZB,R1R,R2H,R3O),(ZB,R1R,R2H,R3P),(ZB,R1R,R2H,R3Q),
(ZB,R1R,R2H,R3R),(ZB,R1R,R2I,R3A),(ZB,R1R,R2I,R3B),
(ZB,R1R,R2I,R3C),(ZB,R1R,R2I,R3D),(ZB,R1R,R2I,R3E),
(ZB,R1R,R2I,R3F),(ZB,R1R,R2I,R3G),(ZB,R1R,R2I,R3H),
(ZB,R1R,R2I,R3I),(ZB,R1R,R2I,R3J),(ZB,R1R,R2I,R3K),
(ZB,R1R,R2I,R3L),(ZB,R1R,R2I,R3M),(ZB,R1R,R2I,R3N),
(ZB,R1R,R2I,R3O),(ZB,R1R,R2I,R3P),(ZB,R1R,R2I,R3Q),
(ZB,R1R,R2I,R3R),(ZB,R1R,R2J,R3A),(ZB,R1R,R2J,R3B),
(ZB,R1R,R2J,R3C),(ZB,R1R,R2J,R3D),(ZB,R1R,R2J,R3E),
(ZB,R1R,R2J,R3F),(ZB,R1R,R2J,R3G),(ZB,R1R,R2J,R3H),
(ZB,R1R,R2J,R3I),(ZB,R1R,R2J,R3J),(ZB,R1R,R2J,R3K),
(ZB,R1R,R2J,R3L),(ZB,R1R,R2J,R3M),(ZB,R1R,R2J,R3N),
(ZB,R1R,R2J,R3O),(ZB,R1R,R2J,R3P),(ZB,R1R,R2J,R3Q),
(ZB,R1R,R2J,R3R),(ZB,R1R,R2K,R3A),(ZB,R1R,R2K,R3B),
(ZB,R1R,R2K,R3C),(ZB,R1R,R2K,R3D),(ZB,R1R,R2K,R3E),
(ZB,R1R,R2K,R3F),(ZB,R1R,R2K,R3G),(ZB,R1R,R2K,R3H),
(ZB,R1R,R2K,R3I),(ZB,R1R,R2K,R3J),(ZB,R1R,R2K,R3K),
(ZB,R1R,R2K,R3L),(ZB,R1R,R2K,R3M),(ZB,R1R,R2K,R3N),
(ZB,R1R,R2K,R3O),(ZB,R1R,R2K,R3P),(ZB,R1R,R2K,R3Q),
(ZB,R1R,R2K,R3R),(ZB,R1R,R2L,R3A),(ZB,R1R,R2L,R3B),
(ZB,R1R,R2L,R3C),(ZB,R1R,R2L,R3D),(ZB,R1R,R2L,R3E),
(ZB,R1R,R2L,R3F),(ZB,R1R,R2L,R3G),(ZB,R1R,R2L,R3H),
(ZB,R1R,R2L,R3I),(ZB,R1R,R2L,R3J),(ZB,R1R,R2L,R3K),
(ZB,R1R,R2L,R3L),(ZB,R1R,R2L,R3M),(ZB,R1R,R2L,R3N),
(ZB,R1R,R2L,R3O),(ZB,R1R,R2L,R3P),(ZB,R1R,R2L,R3Q),
(ZB,R1R,R2L,R3R),(ZB,R1R,R2M,R3A),(ZB,R1R,R2M,R3B),
(ZB,R1R,R2M,R3C),(ZB,R1R,R2M,R3D),(ZB,R1R,R2M,R3E),
(ZB,R1R,R2M,R3F),(ZB,R1R,R2M,R3G),(ZB,R1R,R2M,R3H),
(ZB,R1R,R2M,R3I),(ZB,R1R,R2M,R3J),(ZB,R1R,R2M,R3K),
(ZB,R1R,R2M,R3L),(ZB,R1R,R2M,R3M),(ZB,R1R,R2M,R3N),
(ZB,R1R,R2M,R3O),(ZB,R1R,R2M,R3P),(ZB,R1R,R2M,R3Q),
(ZB,R1R,R2M,R3R),(ZB,R1R,R2N,R3A),(ZB,R1R,R2N,R3B),
(ZB,R1R,R2N,R3C),(ZB,R1R,R2N,R3D),(ZB,R1R,R2N,R3E),
(ZB,R1R,R2N,R3F),(ZB,R1R,R2N,R3G),(ZB,R1R,R2N,R3H),
(ZB,R1R,R2N,R3I),(ZB,R1R,R2N,R3J),(ZB,R1R,R2N,R3K),
(ZB,R1R,R2N,R3L),(ZB,R1R,R2N,R3M),(ZB,R1R,R2N,R3N),
(ZB,R1R,R2N,R3O),(ZB,R1R,R2N,R3P),(ZB,R1R,R2N,R3Q),
(ZB,R1R,R2N,R3R),(ZB,R1S,R2A,R3A),(ZB,R1S,R2A,R3B),
(ZB,R1S,R2A,R3C),(ZB,R1S,R2A,R3D),(ZB,R1S,R2A,R3E),
(ZB,R1S,R2A,R3F),(ZB,R1S,R2A,R3G),(ZB,R1S,R2A,R3H),
(ZB,R1S,R2A,R3I),(ZB,R1S,R2A,R3J),(ZB,R1S,R2A,R3K),
(ZB,R1S,R2A,R3L),(ZB,R1S,R2A,R3M),(ZB,R1S,R2A,R3N),
(ZB,R1S,R2A,R3O),(ZB,R1S,R2A,R3P),(ZB,R1S,R2A,R3Q),
(ZB,R1S,R2A,R3R),(ZB,R1S,R2B,R3A),(ZB,R1S,R2B,R3B),
(ZB,R1S,R2B,R3C),(ZB,R1S,R2B,R3D),(ZB,R1S,R2B,R3E),
(ZB,R1S,R2B,R3F),(ZB,R1S,R2B,R3G),(ZB,R1S,R2B,R3H),
(ZB,R1S,R2B,R3I),(ZB,R1S,R2B,R3J),(ZB,R1S,R2B,R3K),
(ZB,R1S,R2B,R3L),(ZB,R1S,R2B,R3M),(ZB,R1S,R2B,R3N),
(ZB,R1S,R2B,R3O),(ZB,R1S,R2B,R3P),(ZB,R1S,R2B,R3Q),
(ZB,R1S,R2B,R3R),(ZB,R1S,R2C,R3A),(ZB,R1S,R2C,R3B),
(ZB,R1S,R2C,R3C),(ZB,R1S,R2C,R3D),(ZB,R1S,R2C,R3E),
(ZB,R1S,R2C,R3F),(ZB,R1S,R2C,R3G),(ZB,R1S,R2C,R3H),
(ZB,R1S,R2C,R3I),(ZB,R1S,R2C,R3J),(ZB,R1S,R2C,R3K),
(ZB,R1S,R2C,R3L),(ZB,R1S,R2C,R3M),(ZB,R1S,R2C,R3N),
(ZB,R1S,R2C,R3O),(ZB,R1S,R2C,R3P),(ZB,R1S,R2C,R3Q),
(ZB,R1S,R2C,R3R),(ZB,R1S,R2D,R3A),(ZB,R1S,R2D,R3B),
(ZB,R1S,R2D,R3C),(ZB,R1S,R2D,R3D),(ZB,R1S,R2D,R3E),
(ZB,R1S,R2D,R3F),(ZB,R1S,R2D,R3G),(ZB,R1S,R2D,R3H),
(ZB,R1S,R2D,R3I),(ZB,R1S,R2D,R3J),(ZB,R1S,R2D,R3K),
(ZB,R1S,R2D,R3L),(ZB,R1S,R2D,R3M),(ZB,R1S,R2D,R3N),
(ZB,R1S,R2D,R3O),(ZB,R1S,R2D,R3P),(ZB,R1S,R2D,R3Q),
(ZB,R1S,R2D,R3R),(ZB,R1S,R2E,R3A),(ZB,R1S,R2E,R3B),
(ZB,R1S,R2E,R3C),(ZB,R1S,R2E,R3D),(ZB,R1S,R2E,R3E),
(ZB,R1S,R2E,R3F),(ZB,R1S,R2E,R3G),(ZB,R1S,R2E,R3H),
(ZB,R1S,R2E,R3I),(ZB,R1S,R2E,R3J),(ZB,R1S,R2E,R3K),
(ZB,R1S,R2E,R3L),(ZB,R1S,R2E,R3M),(ZB,R1S,R2E,R3N),
(ZB,R1S,R2E,R3O),(ZB,R1S,R2E,R3P),(ZB,R1S,R2E,R3Q),
(ZB,R1S,R2E,R3R),(ZB,R1S,R2F,R3A),(ZB,R1S,R2F,R3B),
(ZB,R1S,R2F,R3C),(ZB,R1S,R2F,R3D),(ZB,R1S,R2F,R3E),
(ZB,R1S,R2F,R3F),(ZB,R1S,R2F,R3G),(ZB,R1S,R2F,R3H),
(ZB,R1S,R2F,R3I),(ZB,R1S,R2F,R3J),(ZB,R1S,R2F,R3K),
(ZB,R1S,R2F,R3L),(ZB,R1S,R2F,R3M),(ZB,R1S,R2F,R3N),
(ZB,R1S,R2F,R3O),(ZB,R1S,R2F,R3P),(ZB,R1S,R2F,R3Q),
(ZB,R1S,R2F,R3R),(ZB,R1S,R2G,R3A),(ZB,R1S,R2G,R3B),
(ZB,R1S,R2G,R3C),(ZB,R1S,R2G,R3D),(ZB,R1S,R2G,R3E),
(ZB,R1S,R2G,R3F),(ZB,R1S,R2G,R3G),(ZB,R1S,R2G,R3H),
(ZB,R1S,R2G,R3I),(ZB,R1S,R2G,R3J),(ZB,R1S,R2G,R3K),
(ZB,R1S,R2G,R3L),(ZB,R1S,R2G,R3M),(ZB,R1S,R2G,R3N),
(ZB,R1S,R2G,R3O),(ZB,R1S,R2G,R3P),(ZB,R1S,R2G,R3Q),
(ZB,R1S,R2G,R3R),(ZB,R1S,R2H,R3A),(ZB,R1S,R2H,R3B),
(ZB,R1S,R2H,R3C),(ZB,R1S,R2H,R3D),(ZB,R1S,R2H,R3E),
(ZB,R1S,R2H,R3F),(ZB,R1S,R2H,R3G),(ZB,R1S,R2H,R3H),
(ZB,R1S,R2H,R3I),(ZB,R1S,R2H,R3J),(ZB,R1S,R2H,R3K),
(ZB,R1S,R2H,R3L),(ZB,R1S,R2H,R3M),(ZB,R1S,R2H,R3N),
(ZB,R1S,R2H,R3O),(ZB,R1S,R2H,R3P),(ZB,R1S,R2H,R3Q),
(ZB,R1S,R2H,R3R),(ZB,R1S,R2I,R3A),(ZB,R1S,R2I,R3B),
(ZB,R1S,R2I,R3C),(ZB,R1S,R2I,R3D),(ZB,R1S,R2I,R3E),
(ZB,R1S,R2I,R3F),(ZB,R1S,R2I,R3G),(ZB,R1S,R2I,R3H),
(ZB,R1S,R2I,R3I),(ZB,R1S,R2I,R3J),(ZB,R1S,R2I,R3K),
(ZB,R1S,R2I,R3L),(ZB,R1S,R2I,R3M),(ZB,R1S,R2I,R3N),
(ZB,R1S,R2I,R3O),(ZB,R1S,R2I,R3P),(ZB,R1S,R2I,R3Q),
(ZB,R1S,R2I,R3R),(ZB,R1S,R2J,R3A),(ZB,R1S,R2J,R3B),
(ZB,R1S,R2J,R3C),(ZB,R1S,R2J,R3D),(ZB,R1S,R2J,R3E),
(ZB,R1S,R2J,R3F),(ZB,R1S,R2J,R3G),(ZB,R1S,R2J,R3H),
(ZB,R1S,R2J,R3I),(ZB,R1S,R2J,R3J),(ZB,R1S,R2J,R3K),
(ZB,R1S,R2J,R3L),(ZB,R1S,R2J,R3M),(ZB,R1S,R2J,R3N),
(ZB,R1S,R2J,R3O),(ZB,R1S,R2J,R3P),(ZB,R1S,R2J,R3Q),
(ZB,R1S,R2J,R3R),(ZB,R1S,R2K,R3A),(ZB,R1S,R2K,R3B),
(ZB,R1S,R2K,R3C),(ZB,R1S,R2K,R3D),(ZB,R1S,R2K,R3E),
(ZB,R1S,R2K,R3F),(ZB,R1S,R2K,R3G),(ZB,R1S,R2K,R3H),
(ZB,R1S,R2K,R3I),(ZB,R1S,R2K,R3J),(ZB,R1S,R2K,R3K),
(ZB,R1S,R2K,R3L),(ZB,R1S,R2K,R3M),(ZB,R1S,R2K,R3N),
(ZB,R1S,R2K,R3O),(ZB,R1S,R2K,R3P),(ZB,R1S,R2K,R3Q),
(ZB,R1S,R2K,R3R),(ZB,R1S,R2L,R3A),(ZB,R1S,R2L,R3B),
(ZB,R1S,R2L,R3C),(ZB,R1S,R2L,R3D),(ZB,R1S,R2L,R3E),
(ZB,R1S,R2L,R3F),(ZB,R1S,R2L,R3G),(ZB,R1S,R2L,R3H),
(ZB,R1S,R2L,R3I),(ZB,R1S,R2L,R3J),(ZB,R1S,R2L,R3K),
(ZB,R1S,R2L,R3L),(ZB,R1S,R2L,R3M),(ZB,R1S,R2L,R3N),
(ZB,R1S,R2L,R3O),(ZB,R1S,R2L,R3P),(ZB,R1S,R2L,R3Q),
(ZB,R1S,R2L,R3R),(ZB,R1S,R2M,R3A),(ZB,R1S,R2M,R3B),
(ZB,R1S,R2M,R3C),(ZB,R1S,R2M,R3D),(ZB,R1S,R2M,R3E),
(ZB,R1S,R2M,R3F),(ZB,R1S,R2M,R3G),(ZB,R1S,R2M,R3H),
(ZB,R1S,R2M,R3I),(ZB,R1S,R2M,R3J),(ZB,R1S,R2M,R3K),
(ZB,R1S,R2M,R3L),(ZB,R1S,R2M,R3M),(ZB,R1S,R2M,R3N),
(ZB,R1S,R2M,R3O),(ZB,R1S,R2M,R3P),(ZB,R1S,R2M,R3Q),
(ZB,R1S,R2M,R3R),(ZB,R1S,R2N,R3A),(ZB,R1S,R2N,R3B),
(ZB,R1S,R2N,R3C),(ZB,R1S,R2N,R3D),(ZB,R1S,R2N,R3E),
(ZB,R1S,R2N,R3F),(ZB,R1S,R2N,R3G),(ZB,R1S,R2N,R3H),
(ZB,R1S,R2N,R3I),(ZB,R1S,R2N,R3J),(ZB,R1S,R2N,R3K),
(ZB,R1S,R2N,R3L),(ZB,R1S,R2N,R3M),(ZB,R1S,R2N,R3N),
(ZB,R1S,R2N,R3O),(ZB,R1S,R2N,R3P),(ZB,R1S,R2N,R3Q),
(ZB,R1S,R2N,R3R),(ZC,R1A,R2A,R3A),(ZC,R1A,R2A,R3B),
(ZC,R1A,R2A,R3C),(ZC,R1A,R2A,R3D),(ZC,R1A,R2A,R3E),
(ZC,R1A,R2A,R3F),(ZC,R1A,R2A,R3G),(ZC,R1A,R2A,R3H),
(ZC,R1A,R2A,R3I),(ZC,R1A,R2A,R3J),(ZC,R1A,R2A,R3K),
(ZC,R1A,R2A,R3L),(ZC,R1A,R2A,R3M),(ZC,R1A,R2A,R3N),
(ZC,R1A,R2A,R3O),(ZC,R1A,R2A,R3P),(ZC,R1A,R2A,R3Q),
(ZC,R1A,R2A,R3R),(ZC,R1A,R2B,R3A),(ZC,R1A,R2B,R3B),
(ZC,R1A,R2B,R3C),(ZC,R1A,R2B,R3D),(ZC,R1A,R2B,R3E),
(ZC,R1A,R2B,R3F),(ZC,R1A,R2B,R3G),(ZC,R1A,R2B,R3H),
(ZC,R1A,R2B,R3I),(ZC,R1A,R2B,R3J),(ZC,R1A,R2B,R3K),
(ZC,R1A,R2B,R3L),(ZC,R1A,R2B,R3M),(ZC,R1A,R2B,R3N),
(ZC,R1A,R2B,R3O),(ZC,R1A,R2B,R3P),(ZC,R1A,R2B,R3Q),
(ZC,R1A,R2B,R3R),(ZC,R1A,R2C,R3A),(ZC,R1A,R2C,R3B),
(ZC,R1A,R2C,R3C),(ZC,R1A,R2C,R3D),(ZC,R1A,R2C,R3E),
(ZC,R1A,R2C,R3F),(ZC,R1A,R2C,R3G),(ZC,R1A,R2C,R3H),
(ZC,R1A,R2C,R3I),(ZC,R1A,R2C,R3J),(ZC,R1A,R2C,R3K),
(ZC,R1A,R2C,R3L),(ZC,R1A,R2C,R3M),(ZC,R1A,R2C,R3N),
(ZC,R1A,R2C,R3O),(ZC,R1A,R2C,R3P),(ZC,R1A,R2C,R3Q),
(ZC,R1A,R2C,R3R),(ZC,R1A,R2D,R3A),(ZC,R1A,R2D,R3B),
(ZC,R1A,R2D,R3C),(ZC,R1A,R2D,R3D),(ZC,R1A,R2D,R3E),
(ZC,R1A,R2D,R3F),(ZC,R1A,R2D,R3G),(ZC,R1A,R2D,R3H),
(ZC,R1A,R2D,R3I),(ZC,R1A,R2D,R3J),(ZC,R1A,R2D,R3K),
(ZC,R1A,R2D,R3L),(ZC,R1A,R2D,R3M),(ZC,R1A,R2D,R3N),
(ZC,R1A,R2D,R3O),(ZC,R1A,R2D,R3P),(ZC,R1A,R2D,R3Q),
(ZC,R1A,R2D,R3R),(ZC,R1A,R2E,R3A),(ZC,R1A,R2E,R3B),
(ZC,R1A,R2E,R3C),(ZC,R1A,R2E,R3D),(ZC,R1A,R2E,R3E),
(ZC,R1A,R2E,R3F),(ZC,R1A,R2E,R3G),(ZC,R1A,R2E,R3H),
(ZC,R1A,R2E,R3I),(ZC,R1A,R2E,R3J),(ZC,R1A,R2E,R3K),
(ZC,R1A,R2E,R3L),(ZC,R1A,R2E,R3M),(ZC,R1A,R2E,R3N),
(ZC,R1A,R2E,R3O),(ZC,R1A,R2E,R3P),(ZC,R1A,R2E,R3Q),
(ZC,R1A,R2E,R3R),(ZC,R1A,R2F,R3A),(ZC,R1A,R2F,R3B),
(ZC,R1A,R2F,R3C),(ZC,R1A,R2F,R3D),(ZC,R1A,R2F,R3E),
(ZC,R1A,R2F,R3F),(ZC,R1A,R2F,R3G),(ZC,R1A,R2F,R3H),
(ZC,R1A,R2F,R3I),(ZC,R1A,R2F,R3J),(ZC,R1A,R2F,R3K),
(ZC,R1A,R2F,R3L),(ZC,R1A,R2F,R3M),(ZC,R1A,R2F,R3N),
(ZC,R1A,R2F,R3O),(ZC,R1A,R2F,R3P),(ZC,R1A,R2F,R3Q),
(ZC,R1A,R2F,R3R),(ZC,R1A,R2G,R3A),(ZC,R1A,R2G,R3B),
(ZC,R1A,R2G,R3C),(ZC,R1A,R2G,R3D),(ZC,R1A,R2G,R3E),
(ZC,R1A,R2G,R3F),(ZC,R1A,R2G,R3G),(ZC,R1A,R2G,R3H),
(ZC,R1A,R2G,R3I),(ZC,R1A,R2G,R3J),(ZC,R1A,R2G,R3K),
(ZC,R1A,R2G,R3L),(ZC,R1A,R2G,R3M),(ZC,R1A,R2G,R3N),
(ZC,R1A,R2G,R3O),(ZC,R1A,R2G,R3P),(ZC,R1A,R2G,R3Q),
(ZC,R1A,R2G,R3R),(ZC,R1A,R2H,R3A),(ZC,R1A,R2H,R3B),
(ZC,R1A,R2H,R3C),(ZC,R1A,R2H,R3D),(ZC,R1A,R2H,R3E),
(ZC,R1A,R2H,R3F),(ZC,R1A,R2H,R3G),(ZC,R1A,R2H,R3H),
(ZC,R1A,R2H,R3I),(ZC,R1A,R2H,R3J),(ZC,R1A,R2H,R3K),
(ZC,R1A,R2H,R3L),(ZC,R1A,R2H,R3M),(ZC,R1A,R2H,R3N),
(ZC,R1A,R2H,R3O),(ZC,R1A,R2H,R3P),(ZC,R1A,R2H,R3Q),
(ZC,R1A,R2H,R3R),(ZC,R1A,R2I,R3A),(ZC,R1A,R2I,R3B),
(ZC,R1A,R2I,R3C),(ZC,R1A,R2I,R3D),(ZC,R1A,R2I,R3E),
(ZC,R1A,R2I,R3F),(ZC,R1A,R2I,R3G),(ZC,R1A,R2I,R3H),
(ZC,R1A,R2I,R3I),(ZC,R1A,R2I,R3J),(ZC,R1A,R2I,R3K),
(ZC,R1A,R2I,R3L),(ZC,R1A,R2I,R3M),(ZC,R1A,R2I,R3N),
(ZC,R1A,R2I,R3O),(ZC,R1A,R2I,R3P),(ZC,R1A,R2I,R3Q),
(ZC,R1A,R2I,R3R),(ZC,R1A,R2J,R3A),(ZC,R1A,R2J,R3B),
(ZC,R1A,R2J,R3C),(ZC,R1A,R2J,R3D),(ZC,R1A,R2J,R3E),
(ZC,R1A,R2J,R3F),(ZC,R1A,R2J,R3G),(ZC,R1A,R2J,R3H),
(ZC,R1A,R2J,R3I),(ZC,R1A,R2J,R3J),(ZC,R1A,R2J,R3K),
(ZC,R1A,R2J,R3L),(ZC,R1A,R2J,R3M),(ZC,R1A,R2J,R3N),
(ZC,R1A,R2J,R3O),(ZC,R1A,R2J,R3P),(ZC,R1A,R2J,R3Q),
(ZC,R1A,R2J,R3R),(ZC,R1A,R2K,R3A),(ZC,R1A,R2K,R3B),
(ZC,R1A,R2K,R3C),(ZC,R1A,R2K,R3D),(ZC,R1A,R2K,R3E),
(ZC,R1A,R2K,R3F),(ZC,R1A,R2K,R3G),(ZC,R1A,R2K,R3H),
(ZC,R1A,R2K,R3I),(ZC,R1A,R2K,R3J),(ZC,R1A,R2K,R3K),
(ZC,R1A,R2K,R3L),(ZC,R1A,R2K,R3M),(ZC,R1A,R2K,R3N),
(ZC,R1A,R2K,R3O),(ZC,R1A,R2K,R3P),(ZC,R1A,R2K,R3Q),
(ZC,R1A,R2K,R3R),(ZC,R1A,R2L,R3A),(ZC,R1A,R2L,R3B),
(ZC,R1A,R2L,R3C),(ZC,R1A,R2L,R3D),(ZC,R1A,R2L,R3E),
(ZC,R1A,R2L,R3F),(ZC,R1A,R2L,R3G),(ZC,R1A,R2L,R3H),
(ZC,R1A,R2L,R3I),(ZC,R1A,R2L,R3J),(ZC,R1A,R2L,R3K),
(ZC,R1A,R2L,R3L),(ZC,R1A,R2L,R3M),(ZC,R1A,R2L,R3N),
(ZC,R1A,R2L,R3O),(ZC,R1A,R2L,R3P),(ZC,R1A,R2L,R3Q),
(ZC,R1A,R2L,R3R),(ZC,R1A,R2M,R3A),(ZC,R1A,R2M,R3B),
(ZC,R1A,R2M,R3C),(ZC,R1A,R2M,R3D),(ZC,R1A,R2M,R3E),
(ZC,R1A,R2M,R3F),(ZC,R1A,R2M,R3G),(ZC,R1A,R2M,R3H),
(ZC,R1A,R2M,R3I),(ZC,R1A,R2M,R3J),(ZC,R1A,R2M,R3K),
(ZC,R1A,R2M,R3L),(ZC,R1A,R2M,R3M),(ZC,R1A,R2M,R3N),
(ZC,R1A,R2M,R3O),(ZC,R1A,R2M,R3P),(ZC,R1A,R2M,R3Q),
(ZC,R1A,R2M,R3R),(ZC,R1A,R2N,R3A),(ZC,R1A,R2N,R3B),
(ZC,R1A,R2N,R3C),(ZC,R1A,R2N,R3D),(ZC,R1A,R2N,R3E),
(ZC,R1A,R2N,R3F),(ZC,R1A,R2N,R3G),(ZC,R1A,R2N,R3H),
(ZC,R1A,R2N,R3I),(ZC,R1A,R2N,R3J),(ZC,R1A,R2N,R3K),
(ZC,R1A,R2N,R3L),(ZC,R1A,R2N,R3M),(ZC,R1A,R2N,R3N),
(ZC,R1A,R2N,R3O),(ZC,R1A,R2N,R3P),(ZC,R1A,R2N,R3Q),
(ZC,R1A,R2N,R3R),(ZC,R1B,R2A,R3A),(ZC,R1B,R2A,R3B),
(ZC,R1B,R2A,R3C),(ZC,R1B,R2A,R3D),(ZC,R1B,R2A,R3E),
(ZC,R1B,R2A,R3F),(ZC,R1B,R2A,R3G),(ZC,R1B,R2A,R3H),
(ZC,R1B,R2A,R3I),(ZC,R1B,R2A,R3J),(ZC,R1B,R2A,R3K),
(ZC,R1B,R2A,R3L),(ZC,R1B,R2A,R3M),(ZC,R1B,R2A,R3N),
(ZC,R1B,R2A,R3O),(ZC,R1B,R2A,R3P),(ZC,R1B,R2A,R3Q),
(ZC,R1B,R2A,R3R),(ZC,R1B,R2B,R3A),(ZC,R1B,R2B,R3B),
(ZC,R1B,R2B,R3C),(ZC,R1B,R2B,R3D),(ZC,R1B,R2B,R3E),
(ZC,R1B,R2B,R3F),(ZC,R1B,R2B,R3G),(ZC,R1B,R2B,R3H),
(ZC,R1B,R2B,R3I),(ZC,R1B,R2B,R3J),(ZC,R1B,R2B,R3K),
(ZC,R1B,R2B,R3L),(ZC,R1B,R2B,R3M),(ZC,R1B,R2B,R3N),
(ZC,R1B,R2B,R3O),(ZC,R1B,R2B,R3P),(ZC,R1B,R2B,R3Q),
(ZC,R1B,R2B,R3R),(ZC,R1B,R2C,R3A),(ZC,R1B,R2C,R3B),
(ZC,R1B,R2C,R3C),(ZC,R1B,R2C,R3D),(ZC,R1B,R2C,R3E),
(ZC,R1B,R2C,R3F),(ZC,R1B,R2C,R3G),(ZC,R1B,R2C,R3H),
(ZC,R1B,R2C,R3I),(ZC,R1B,R2C,R3J),(ZC,R1B,R2C,R3K),
(ZC,R1B,R2C,R3L),(ZC,R1B,R2C,R3M),(ZC,R1B,R2C,R3N),
(ZC,R1B,R2C,R3O),(ZC,R1B,R2C,R3P),(ZC,R1B,R2C,R3Q),
(ZC,R1B,R2C,R3R),(ZC,R1B,R2D,R3A),(ZC,R1B,R2D,R3B),
(ZC,R1B,R2D,R3C),(ZC,R1B,R2D,R3D),(ZC,R1B,R2D,R3E),
(ZC,R1B,R2D,R3F),(ZC,R1B,R2D,R3G),(ZC,R1B,R2D,R3H),
(ZC,R1B,R2D,R3I),(ZC,R1B,R2D,R3J),(ZC,R1B,R2D,R3K),
(ZC,R1B,R2D,R3L),(ZC,R1B,R2D,R3M),(ZC,R1B,R2D,R3N),
(ZC,R1B,R2D,R3O),(ZC,R1B,R2D,R3P),(ZC,R1B,R2D,R3Q),
(ZC,R1B,R2D,R3R),(ZC,R1B,R2E,R3A),(ZC,R1B,R2E,R3B),
(ZC,R1B,R2E,R3C),(ZC,R1B,R2E,R3D),(ZC,R1B,R2E,R3E),
(ZC,R1B,R2E,R3F),(ZC,R1B,R2E,R3G),(ZC,R1B,R2E,R3H),
(ZC,R1B,R2E,R3I),(ZC,R1B,R2E,R3J),(ZC,R1B,R2E,R3K),
(ZC,R1B,R2E,R3L),(ZC,R1B,R2E,R3M),(ZC,R1B,R2E,R3N),
(ZC,R1B,R2E,R3O),(ZC,R1B,R2E,R3P),(ZC,R1B,R2E,R3Q),
(ZC,R1B,R2E,R3R),(ZC,R1B,R2F,R3A),(ZC,R1B,R2F,R3B),
(ZC,R1B,R2F,R3C),(ZC,R1B,R2F,R3D),(ZC,R1B,R2F,R3E),
(ZC,R1B,R2F,R3F),(ZC,R1B,R2F,R3G),(ZC,R1B,R2F,R3H),
(ZC,R1B,R2F,R3I),(ZC,R1B,R2F,R3J),(ZC,R1B,R2F,R3K),
(ZC,R1B,R2F,R3L),(ZC,R1B,R2F,R3M),(ZC,R1B,R2F,R3N),
(ZC,R1B,R2F,R3O),(ZC,R1B,R2F,R3P),(ZC,R1B,R2F,R3Q),
(ZC,R1B,R2F,R3R),(ZC,R1B,R2G,R3A),(ZC,R1B,R2G,R3B),
(ZC,R1B,R2G,R3C),(ZC,R1B,R2G,R3D),(ZC,R1B,R2G,R3E),
(ZC,R1B,R2G,R3F),(ZC,R1B,R2G,R3G),(ZC,R1B,R2G,R3H),
(ZC,R1B,R2G,R3I),(ZC,R1B,R2G,R3J),(ZC,R1B,R2G,R3K),
(ZC,R1B,R2G,R3L),(ZC,R1B,R2G,R3M),(ZC,R1B,R2G,R3N),
(ZC,R1B,R2G,R3O),(ZC,R1B,R2G,R3P),(ZC,R1B,R2G,R3Q),
(ZC,R1B,R2G,R3R),(ZC,R1B,R2H,R3A),(ZC,R1B,R2H,R3B),
(ZC,R1B,R2H,R3C),(ZC,R1B,R2H,R3D),(ZC,R1B,R2H,R3E),
(ZC,R1B,R2H,R3F),(ZC,R1B,R2H,R3G),(ZC,R1B,R2H,R3H),
(ZC,R1B,R2H,R3I),(ZC,R1B,R2H,R3J),(ZC,R1B,R2H,R3K),
(ZC,R1B,R2H,R3L),(ZC,R1B,R2H,R3M),(ZC,R1B,R2H,R3N),
(ZC,R1B,R2H,R3O),(ZC,R1B,R2H,R3P),(ZC,R1B,R2H,R3Q),
(ZC,R1B,R2H,R3R),(ZC,R1B,R2I,R3A),(ZC,R1B,R2I,R3B),
(ZC,R1B,R2I,R3C),(ZC,R1B,R2I,R3D),(ZC,R1B,R2I,R3E),
(ZC,R1B,R2I,R3F),(ZC,R1B,R2I,R3G),(ZC,R1B,R2I,R3H),
(ZC,R1B,R2I,R3I),(ZC,R1B,R2I,R3J),(ZC,R1B,R2I,R3K),
(ZC,R1B,R2I,R3L),(ZC,R1B,R2I,R3M),(ZC,R1B,R2I,R3N),
(ZC,R1B,R2I,R3O),(ZC,R1B,R2I,R3P),(ZC,R1B,R2I,R3Q),
(ZC,R1B,R2I,R3R),(ZC,R1B,R2J,R3A),(ZC,R1B,R2J,R3B),
(ZC,R1B,R2J,R3C),(ZC,R1B,R2J,R3D),(ZC,R1B,R2J,R3E),
(ZC,R1B,R2J,R3F),(ZC,R1B,R2J,R3G),(ZC,R1B,R2J,R3H),
(ZC,R1B,R2J,R3I),(ZC,R1B,R2J,R3J),(ZC,R1B,R2J,R3K),
(ZC,R1B,R2J,R3L),(ZC,R1B,R2J,R3M),(ZC,R1B,R2J,R3N),
(ZC,R1B,R2J,R3O),(ZC,R1B,R2J,R3P),(ZC,R1B,R2J,R3Q),
(ZC,R1B,R2J,R3R),(ZC,R1B,R2K,R3A),(ZC,R1B,R2K,R3B),
(ZC,R1B,R2K,R3C),(ZC,R1B,R2K,R3D),(ZC,R1B,R2K,R3E),
(ZC,R1B,R2K,R3F),(ZC,R1B,R2K,R3G),(ZC,R1B,R2K,R3H),
(ZC,R1B,R2K,R3I),(ZC,R1B,R2K,R3J),(ZC,R1B,R2K,R3K),
(ZC,R1B,R2K,R3L),(ZC,R1B,R2K,R3M),(ZC,R1B,R2K,R3N),
(ZC,R1B,R2K,R3O),(ZC,R1B,R2K,R3P),(ZC,R1B,R2K,R3Q),
(ZC,R1B,R2K,R3R),(ZC,R1B,R2L,R3A),(ZC,R1B,R2L,R3B),
(ZC,R1B,R2L,R3C),(ZC,R1B,R2L,R3D),(ZC,R1B,R2L,R3E),
(ZC,R1B,R2L,R3F),(ZC,R1B,R2L,R3G),(ZC,R1B,R2L,R3H),
(ZC,R1B,R2L,R3I),(ZC,R1B,R2L,R3J),(ZC,R1B,R2L,R3K),
(ZC,R1B,R2L,R3L),(ZC,R1B,R2L,R3M),(ZC,R1B,R2L,R3N),
(ZC,R1B,R2L,R3O),(ZC,R1B,R2L,R3P),(ZC,R1B,R2L,R3Q),
(ZC,R1B,R2L,R3R),(ZC,R1B,R2M,R3A),(ZC,R1B,R2M,R3B),
(ZC,R1B,R2M,R3C),(ZC,R1B,R2M,R3D),(ZC,R1B,R2M,R3E),
(ZC,R1B,R2M,R3F),(ZC,R1B,R2M,R3G),(ZC,R1B,R2M,R3H),
(ZC,R1B,R2M,R3I),(ZC,R1B,R2M,R3J),(ZC,R1B,R2M,R3K),
(ZC,R1B,R2M,R3L),(ZC,R1B,R2M,R3M),(ZC,R1B,R2M,R3N),
(ZC,R1B,R2M,R3O),(ZC,R1B,R2M,R3P),(ZC,R1B,R2M,R3Q),
(ZC,R1B,R2M,R3R),(ZC,R1B,R2N,R3A),(ZC,R1B,R2N,R3B),
(ZC,R1B,R2N,R3C),(ZC,R1B,R2N,R3D),(ZC,R1B,R2N,R3E),
(ZC,R1B,R2N,R3F),(ZC,R1B,R2N,R3G),(ZC,R1B,R2N,R3H),
(ZC,R1B,R2N,R3I),(ZC,R1B,R2N,R3J),(ZC,R1B,R2N,R3K),
(ZC,R1B,R2N,R3L),(ZC,R1B,R2N,R3M),(ZC,R1B,R2N,R3N),
(ZC,R1B,R2N,R3O),(ZC,R1B,R2N,R3P),(ZC,R1B,R2N,R3Q),
(ZC,R1B,R2N,R3R),(ZC,R1C,R2A,R3A),(ZC,R1C,R2A,R3B),
(ZC,R1C,R2A,R3C),(ZC,R1C,R2A,R3D),(ZC,R1C,R2A,R3E),
(ZC,R1C,R2A,R3F),(ZC,R1C,R2A,R3G),(ZC,R1C,R2A,R3H),
(ZC,R1C,R2A,R3I),(ZC,R1C,R2A,R3J),(ZC,R1C,R2A,R3K),
(ZC,R1C,R2A,R3L),(ZC,R1C,R2A,R3M),(ZC,R1C,R2A,R3N),
(ZC,R1C,R2A,R3O),(ZC,R1C,R2A,R3P),(ZC,R1C,R2A,R3Q),
(ZC,R1C,R2A,R3R),(ZC,R1C,R2B,R3A),(ZC,R1C,R2B,R3B),
(ZC,R1C,R2B,R3C),(ZC,R1C,R2B,R3D),(ZC,R1C,R2B,R3E),
(ZC,R1C,R2B,R3F),(ZC,R1C,R2B,R3G),(ZC,R1C,R2B,R3H),
(ZC,R1C,R2B,R3I),(ZC,R1C,R2B,R3J),(ZC,R1C,R2B,R3K),
(ZC,R1C,R2B,R3L),(ZC,R1C,R2B,R3M),(ZC,R1C,R2B,R3N),
(ZC,R1C,R2B,R3O),(ZC,R1C,R2B,R3P),(ZC,R1C,R2B,R3Q),
(ZC,R1C,R2B,R3R),(ZC,R1C,R2C,R3A),(ZC,R1C,R2C,R3B),
(ZC,R1C,R2C,R3C),(ZC,R1C,R2C,R3D),(ZC,R1C,R2C,R3E),
(ZC,R1C,R2C,R3F),(ZC,R1C,R2C,R3G),(ZC,R1C,R2C,R3H),
(ZC,R1C,R2C,R3I),(ZC,R1C,R2C,R3J),(ZC,R1C,R2C,R3K),
(ZC,R1C,R2C,R3L),(ZC,R1C,R2C,R3M),(ZC,R1C,R2C,R3N),
(ZC,R1C,R2C,R3O),(ZC,R1C,R2C,R3P),(ZC,R1C,R2C,R3Q),
(ZC,R1C,R2C,R3R),(ZC,R1C,R2D,R3A),(ZC,R1C,R2D,R3B),
(ZC,R1C,R2D,R3C),(ZC,R1C,R2D,R3D),(ZC,R1C,R2D,R3E),
(ZC,R1C,R2D,R3F),(ZC,R1C,R2D,R3G),(ZC,R1C,R2D,R3H),
(ZC,R1C,R2D,R3I),(ZC,R1C,R2D,R3J),(ZC,R1C,R2D,R3K),
(ZC,R1C,R2D,R3L),(ZC,R1C,R2D,R3M),(ZC,R1C,R2D,R3N),
(ZC,R1C,R2D,R3O),(ZC,R1C,R2D,R3P),(ZC,R1C,R2D,R3Q),
(ZC,R1C,R2D,R3R),(ZC,R1C,R2E,R3A),(ZC,R1C,R2E,R3B),
(ZC,R1C,R2E,R3C),(ZC,R1C,R2E,R3D),(ZC,R1C,R2E,R3E),
(ZC,R1C,R2E,R3F),(ZC,R1C,R2E,R3G),(ZC,R1C,R2E,R3H),
(ZC,R1C,R2E,R3I),(ZC,R1C,R2E,R3J),(ZC,R1C,R2E,R3K),
(ZC,R1C,R2E,R3L),(ZC,R1C,R2E,R3M),(ZC,R1C,R2E,R3N),
(ZC,R1C,R2E,R3O),(ZC,R1C,R2E,R3P),(ZC,R1C,R2E,R3Q),
(ZC,R1C,R2E,R3R),(ZC,R1C,R2F,R3A),(ZC,R1C,R2F,R3B),
(ZC,R1C,R2F,R3C),(ZC,R1C,R2F,R3D),(ZC,R1C,R2F,R3E),
(ZC,R1C,R2F,R3F),(ZC,R1C,R2F,R3G),(ZC,R1C,R2F,R3H),
(ZC,R1C,R2F,R3I),(ZC,R1C,R2F,R3J),(ZC,R1C,R2F,R3K),
(ZC,R1C,R2F,R3L),(ZC,R1C,R2F,R3M),(ZC,R1C,R2F,R3N),
(ZC,R1C,R2F,R3O),(ZC,R1C,R2F,R3P),(ZC,R1C,R2F,R3Q),
(ZC,R1C,R2F,R3R),(ZC,R1C,R2G,R3A),(ZC,R1C,R2G,R3B),
(ZC,R1C,R2G,R3C),(ZC,R1C,R2G,R3D),(ZC,R1C,R2G,R3E),
(ZC,R1C,R2G,R3F),(ZC,R1C,R2G,R3G),(ZC,R1C,R2G,R3H),
(ZC,R1C,R2G,R3I),(ZC,R1C,R2G,R3J),(ZC,R1C,R2G,R3K),
(ZC,R1C,R2G,R3L),(ZC,R1C,R2G,R3M),(ZC,R1C,R2G,R3N),
(ZC,R1C,R2G,R3O),(ZC,R1C,R2G,R3P),(ZC,R1C,R2G,R3Q),
(ZC,R1C,R2G,R3R),(ZC,R1C,R2H,R3A),(ZC,R1C,R2H,R3B),
(ZC,R1C,R2H,R3C),(ZC,R1C,R2H,R3D),(ZC,R1C,R2H,R3E),
(ZC,R1C,R2H,R3F),(ZC,R1C,R2H,R3G),(ZC,R1C,R2H,R3H),
(ZC,R1C,R2H,R3I),(ZC,R1C,R2H,R3J),(ZC,R1C,R2H,R3K),
(ZC,R1C,R2H,R3L),(ZC,R1C,R2H,R3M),(ZC,R1C,R2H,R3N),
(ZC,R1C,R2H,R3O),(ZC,R1C,R2H,R3P),(ZC,R1C,R2H,R3Q),
(ZC,R1C,R2H,R3R),(ZC,R1C,R2I,R3A),(ZC,R1C,R2I,R3B),
(ZC,R1C,R2I,R3C),(ZC,R1C,R2I,R3D),(ZC,R1C,R2I,R3E),
(ZC,R1C,R2I,R3F),(ZC,R1C,R2I,R3G),(ZC,R1C,R2I,R3H),
(ZC,R1C,R2I,R3I),(ZC,R1C,R2I,R3J),(ZC,R1C,R2I,R3K),
(ZC,R1C,R2I,R3L),(ZC,R1C,R2I,R3M),(ZC,R1C,R2I,R3N),
(ZC,R1C,R2I,R3O),(ZC,R1C,R2I,R3P),(ZC,R1C,R2I,R3Q),
(ZC,R1C,R2I,R3R),(ZC,R1C,R2J,R3A),(ZC,R1C,R2J,R3B),
(ZC,R1C,R2J,R3C),(ZC,R1C,R2J,R3D),(ZC,R1C,R2J,R3E),
(ZC,R1C,R2J,R3F),(ZC,R1C,R2J,R3G),(ZC,R1C,R2J,R3H),
(ZC,R1C,R2J,R3I),(ZC,R1C,R2J,R3J),(ZC,R1C,R2J,R3K),
(ZC,R1C,R2J,R3L),(ZC,R1C,R2J,R3M),(ZC,R1C,R2J,R3N),
(ZC,R1C,R2J,R3O),(ZC,R1C,R2J,R3P),(ZC,R1C,R2J,R3Q),
(ZC,R1C,R2J,R3R),(ZC,R1C,R2K,R3A),(ZC,R1C,R2K,R3B),
(ZC,R1C,R2K,R3C),(ZC,R1C,R2K,R3D),(ZC,R1C,R2K,R3E),
(ZC,R1C,R2K,R3F),(ZC,R1C,R2K,R3G),(ZC,R1C,R2K,R3H),
(ZC,R1C,R2K,R3I),(ZC,R1C,R2K,R3J),(ZC,R1C,R2K,R3K),
(ZC,R1C,R2K,R3L),(ZC,R1C,R2K,R3M),(ZC,R1C,R2K,R3N),
(ZC,R1C,R2K,R3O),(ZC,R1C,R2K,R3P),(ZC,R1C,R2K,R3Q),
(ZC,R1C,R2K,R3R),(ZC,R1C,R2L,R3A),(ZC,R1C,R2L,R3B),
(ZC,R1C,R2L,R3C),(ZC,R1C,R2L,R3D),(ZC,R1C,R2L,R3E),
(ZC,R1C,R2L,R3F),(ZC,R1C,R2L,R3G),(ZC,R1C,R2L,R3H),
(ZC,R1C,R2L,R3I),(ZC,R1C,R2L,R3J),(ZC,R1C,R2L,R3K),
(ZC,R1C,R2L,R3L),(ZC,R1C,R2L,R3M),(ZC,R1C,R2L,R3N),
(ZC,R1C,R2L,R3O),(ZC,R1C,R2L,R3P),(ZC,R1C,R2L,R3Q),
(ZC,R1C,R2L,R3R),(ZC,R1C,R2M,R3A),(ZC,R1C,R2M,R3B),
(ZC,R1C,R2M,R3C),(ZC,R1C,R2M,R3D),(ZC,R1C,R2M,R3E),
(ZC,R1C,R2M,R3F),(ZC,R1C,R2M,R3G),(ZC,R1C,R2M,R3H),
(ZC,R1C,R2M,R3I),(ZC,R1C,R2M,R3J),(ZC,R1C,R2M,R3K),
(ZC,R1C,R2M,R3L),(ZC,R1C,R2M,R3M),(ZC,R1C,R2M,R3N),
(ZC,R1C,R2M,R3O),(ZC,R1C,R2M,R3P),(ZC,R1C,R2M,R3Q),
(ZC,R1C,R2M,R3R),(ZC,R1C,R2N,R3A),(ZC,R1C,R2N,R3B),
(ZC,R1C,R2N,R3C),(ZC,R1C,R2N,R3D),(ZC,R1C,R2N,R3E),
(ZC,R1C,R2N,R3F),(ZC,R1C,R2N,R3G),(ZC,R1C,R2N,R3H),
(ZC,R1C,R2N,R3I),(ZC,R1C,R2N,R3J),(ZC,R1C,R2N,R3K),
(ZC,R1C,R2N,R3L),(ZC,R1C,R2N,R3M),(ZC,R1C,R2N,R3N),
(ZC,R1C,R2N,R3O),(ZC,R1C,R2N,R3P),(ZC,R1C,R2N,R3Q),
(ZC,R1C,R2N,R3R),(ZC,R1D,R2A,R3A),(ZC,R1D,R2A,R3B),
(ZC,R1D,R2A,R3C),(ZC,R1D,R2A,R3D),(ZC,R1D,R2A,R3E),
(ZC,R1D,R2A,R3F),(ZC,R1D,R2A,R3G),(ZC,R1D,R2A,R3H),
(ZC,R1D,R2A,R3I),(ZC,R1D,R2A,R3J),(ZC,R1D,R2A,R3K),
(ZC,R1D,R2A,R3L),(ZC,R1D,R2A,R3M),(ZC,R1D,R2A,R3N),
(ZC,R1D,R2A,R3O),(ZC,R1D,R2A,R3P),(ZC,R1D,R2A,R3Q),
(ZC,R1D,R2A,R3R),(ZC,R1D,R2B,R3A),(ZC,R1D,R2B,R3B),
(ZC,R1D,R2B,R3C),(ZC,R1D,R2B,R3D),(ZC,R1D,R2B,R3E),
(ZC,R1D,R2B,R3F),(ZC,R1D,R2B,R3G),(ZC,R1D,R2B,R3H),
(ZC,R1D,R2B,R3I),(ZC,R1D,R2B,R3J),(ZC,R1D,R2B,R3K),
(ZC,R1D,R2B,R3L),(ZC,R1D,R2B,R3M),(ZC,R1D,R2B,R3N),
(ZC,R1D,R2B,R3O),(ZC,R1D,R2B,R3P),(ZC,R1D,R2B,R3Q),
(ZC,R1D,R2B,R3R),(ZC,R1D,R2C,R3A),(ZC,R1D,R2C,R3B),
(ZC,R1D,R2C,R3C),(ZC,R1D,R2C,R3D),(ZC,R1D,R2C,R3E),
(ZC,R1D,R2C,R3F),(ZC,R1D,R2C,R3G),(ZC,R1D,R2C,R3H),
(ZC,R1D,R2C,R3I),(ZC,R1D,R2C,R3J),(ZC,R1D,R2C,R3K),
(ZC,R1D,R2C,R3L),(ZC,R1D,R2C,R3M),(ZC,R1D,R2C,R3N),
(ZC,R1D,R2C,R3O),(ZC,R1D,R2C,R3P),(ZC,R1D,R2C,R3Q),
(ZC,R1D,R2C,R3R),(ZC,R1D,R2D,R3A),(ZC,R1D,R2D,R3B),
(ZC,R1D,R2D,R3C),(ZC,R1D,R2D,R3D),(ZC,R1D,R2D,R3E),
(ZC,R1D,R2D,R3F),(ZC,R1D,R2D,R3G),(ZC,R1D,R2D,R3H),
(ZC,R1D,R2D,R3I),(ZC,R1D,R2D,R3J),(ZC,R1D,R2D,R3K),
(ZC,R1D,R2D,R3L),(ZC,R1D,R2D,R3M),(ZC,R1D,R2D,R3N),
(ZC,R1D,R2D,R3O),(ZC,R1D,R2D,R3P),(ZC,R1D,R2D,R3Q),
(ZC,R1D,R2D,R3R),(ZC,R1D,R2E,R3A),(ZC,R1D,R2E,R3B),
(ZC,R1D,R2E,R3C),(ZC,R1D,R2E,R3D),(ZC,R1D,R2E,R3E),
(ZC,R1D,R2E,R3F),(ZC,R1D,R2E,R3G),(ZC,R1D,R2E,R3H),
(ZC,R1D,R2E,R3I),(ZC,R1D,R2E,R3J),(ZC,R1D,R2E,R3K),
(ZC,R1D,R2E,R3L),(ZC,R1D,R2E,R3M),(ZC,R1D,R2E,R3N),
(ZC,R1D,R2E,R3O),(ZC,R1D,R2E,R3P),(ZC,R1D,R2E,R3Q),
(ZC,R1D,R2E,R3R),(ZC,R1D,R2F,R3A),(ZC,R1D,R2F,R3B),
(ZC,R1D,R2F,R3C),(ZC,R1D,R2F,R3D),(ZC,R1D,R2F,R3E),
(ZC,R1D,R2F,R3F),(ZC,R1D,R2F,R3G),(ZC,R1D,R2F,R3H),
(ZC,R1D,R2F,R3I),(ZC,R1D,R2F,R3J),(ZC,R1D,R2F,R3K),
(ZC,R1D,R2F,R3L),(ZC,R1D,R2F,R3M),(ZC,R1D,R2F,R3N),
(ZC,R1D,R2F,R3O),(ZC,R1D,R2F,R3P),(ZC,R1D,R2F,R3Q),
(ZC,R1D,R2F,R3R),(ZC,R1D,R2G,R3A),(ZC,R1D,R2G,R3B),
(ZC,R1D,R2G,R3C),(ZC,R1D,R2G,R3D),(ZC,R1D,R2G,R3E),
(ZC,R1D,R2G,R3F),(ZC,R1D,R2G,R3G),(ZC,R1D,R2G,R3H),
(ZC,R1D,R2G,R3I),(ZC,R1D,R2G,R3J),(ZC,R1D,R2G,R3K),
(ZC,R1D,R2G,R3L),(ZC,R1D,R2G,R3M),(ZC,R1D,R2G,R3N),
(ZC,R1D,R2G,R3O),(ZC,R1D,R2G,R3P),(ZC,R1D,R2G,R3Q),
(ZC,R1D,R2G,R3R),(ZC,R1D,R2H,R3A),(ZC,R1D,R2H,R3B),
(ZC,R1D,R2H,R3C),(ZC,R1D,R2H,R3D),(ZC,R1D,R2H,R3E),
(ZC,R1D,R2H,R3F),(ZC,R1D,R2H,R3G),(ZC,R1D,R2H,R3H),
(ZC,R1D,R2H,R3I),(ZC,R1D,R2H,R3J),(ZC,R1D,R2H,R3K),
(ZC,R1D,R2H,R3L),(ZC,R1D,R2H,R3M),(ZC,R1D,R2H,R3N),
(ZC,R1D,R2H,R3O),(ZC,R1D,R2H,R3P),(ZC,R1D,R2H,R3Q),
(ZC,R1D,R2H,R3R),(ZC,R1D,R2I,R3A),(ZC,R1D,R2I,R3B),
(ZC,R1D,R2I,R3C),(ZC,R1D,R2I,R3D),(ZC,R1D,R2I,R3E),
(ZC,R1D,R2I,R3F),(ZC,R1D,R2I,R3G),(ZC,R1D,R2I,R3H),
(ZC,R1D,R2I,R3I),(ZC,R1D,R2I,R3J),(ZC,R1D,R2I,R3K),
(ZC,R1D,R2I,R3L),(ZC,R1D,R2I,R3M),(ZC,R1D,R2I,R3N),
(ZC,R1D,R2I,R3O),(ZC,R1D,R2I,R3P),(ZC,R1D,R2I,R3Q),
(ZC,R1D,R2I,R3R),(ZC,R1D,R2J,R3A),(ZC,R1D,R2J,R3B),
(ZC,R1D,R2J,R3C),(ZC,R1D,R2J,R3D),(ZC,R1D,R2J,R3E),
(ZC,R1D,R2J,R3F),(ZC,R1D,R2J,R3G),(ZC,R1D,R2J,R3H),
(ZC,R1D,R2J,R3I),(ZC,R1D,R2J,R3J),(ZC,R1D,R2J,R3K),
(ZC,R1D,R2J,R3L),(ZC,R1D,R2J,R3M),(ZC,R1D,R2J,R3N),
(ZC,R1D,R2J,R3O),(ZC,R1D,R2J,R3P),(ZC,R1D,R2J,R3Q),
(ZC,R1D,R2J,R3R),(ZC,R1D,R2K,R3A),(ZC,R1D,R2K,R3B),
(ZC,R1D,R2K,R3C),(ZC,R1D,R2K,R3D),(ZC,R1D,R2K,R3E),
(ZC,R1D,R2K,R3F),(ZC,R1D,R2K,R3G),(ZC,R1D,R2K,R3H),
(ZC,R1D,R2K,R3I),(ZC,R1D,R2K,R3J),(ZC,R1D,R2K,R3K),
(ZC,R1D,R2K,R3L),(ZC,R1D,R2K,R3M),(ZC,R1D,R2K,R3N),
(ZC,R1D,R2K,R3O),(ZC,R1D,R2K,R3P),(ZC,R1D,R2K,R3Q),
(ZC,R1D,R2K,R3R),(ZC,R1D,R2L,R3A),(ZC,R1D,R2L,R3B),
(ZC,R1D,R2L,R3C),(ZC,R1D,R2L,R3D),(ZC,R1D,R2L,R3E),
(ZC,R1D,R2L,R3F),(ZC,R1D,R2L,R3G),(ZC,R1D,R2L,R3H),
(ZC,R1D,R2L,R3I),(ZC,R1D,R2L,R3J),(ZC,R1D,R2L,R3K),
(ZC,R1D,R2L,R3L),(ZC,R1D,R2L,R3M),(ZC,R1D,R2L,R3N),
(ZC,R1D,R2L,R3O),(ZC,R1D,R2L,R3P),(ZC,R1D,R2L,R3Q),
(ZC,R1D,R2L,R3R),(ZC,R1D,R2M,R3A),(ZC,R1D,R2M,R3B),
(ZC,R1D,R2M,R3C),(ZC,R1D,R2M,R3D),(ZC,R1D,R2M,R3E),
(ZC,R1D,R2M,R3F),(ZC,R1D,R2M,R3G),(ZC,R1D,R2M,R3H),
(ZC,R1D,R2M,R3I),(ZC,R1D,R2M,R3J),(ZC,R1D,R2M,R3K),
(ZC,R1D,R2M,R3L),(ZC,R1D,R2M,R3M),(ZC,R1D,R2M,R3N),
(ZC,R1D,R2M,R3O),(ZC,R1D,R2M,R3P),(ZC,R1D,R2M,R3Q),
(ZC,R1D,R2M,R3R),(ZC,R1D,R2N,R3A),(ZC,R1D,R2N,R3B),
(ZC,R1D,R2N,R3C),(ZC,R1D,R2N,R3D),(ZC,R1D,R2N,R3E),
(ZC,R1D,R2N,R3F),(ZC,R1D,R2N,R3G),(ZC,R1D,R2N,R3H),
(ZC,R1D,R2N,R3I),(ZC,R1D,R2N,R3J),(ZC,R1D,R2N,R3K),
(ZC,R1D,R2N,R3L),(ZC,R1D,R2N,R3M),(ZC,R1D,R2N,R3N),
(ZC,R1D,R2N,R3O),(ZC,R1D,R2N,R3P),(ZC,R1D,R2N,R3Q),
(ZC,R1D,R2N,R3R),(ZC,R1E,R2A,R3A),(ZC,R1E,R2A,R3B),
(ZC,R1E,R2A,R3C),(ZC,R1E,R2A,R3D),(ZC,R1E,R2A,R3E),
(ZC,R1E,R2A,R3F),(ZC,R1E,R2A,R3G),(ZC,R1E,R2A,R3H),
(ZC,R1E,R2A,R3I),(ZC,R1E,R2A,R3J),(ZC,R1E,R2A,R3K),
(ZC,R1E,R2A,R3L),(ZC,R1E,R2A,R3M),(ZC,R1E,R2A,R3N),
(ZC,R1E,R2A,R3O),(ZC,R1E,R2A,R3P),(ZC,R1E,R2A,R3Q),
(ZC,R1E,R2A,R3R),(ZC,R1E,R2B,R3A),(ZC,R1E,R2B,R3B),
(ZC,R1E,R2B,R3C),(ZC,R1E,R2B,R3D),(ZC,R1E,R2B,R3E),
(ZC,R1E,R2B,R3F),(ZC,R1E,R2B,R3G),(ZC,R1E,R2B,R3H),
(ZC,R1E,R2B,R3I),(ZC,R1E,R2B,R3J),(ZC,R1E,R2B,R3K),
(ZC,R1E,R2B,R3L),(ZC,R1E,R2B,R3M),(ZC,R1E,R2B,R3N),
(ZC,R1E,R2B,R3O),(ZC,R1E,R2B,R3P),(ZC,R1E,R2B,R3Q),
(ZC,R1E,R2B,R3R),(ZC,R1E,R2C,R3A),(ZC,R1E,R2C,R3B),
(ZC,R1E,R2C,R3C),(ZC,R1E,R2C,R3D),(ZC,R1E,R2C,R3E),
(ZC,R1E,R2C,R3F),(ZC,R1E,R2C,R3G),(ZC,R1E,R2C,R3H),
(ZC,R1E,R2C,R3I),(ZC,R1E,R2C,R3J),(ZC,R1E,R2C,R3K),
(ZC,R1E,R2C,R3L),(ZC,R1E,R2C,R3M),(ZC,R1E,R2C,R3N),
(ZC,R1E,R2C,R3O),(ZC,R1E,R2C,R3P),(ZC,R1E,R2C,R3Q),
(ZC,R1E,R2C,R3R),(ZC,R1E,R2D,R3A),(ZC,R1E,R2D,R3B),
(ZC,R1E,R2D,R3C),(ZC,R1E,R2D,R3D),(ZC,R1E,R2D,R3E),
(ZC,R1E,R2D,R3F),(ZC,R1E,R2D,R3G),(ZC,R1E,R2D,R3H),
(ZC,R1E,R2D,R3I),(ZC,R1E,R2D,R3J),(ZC,R1E,R2D,R3K),
(ZC,R1E,R2D,R3L),(ZC,R1E,R2D,R3M),(ZC,R1E,R2D,R3N),
(ZC,R1E,R2D,R3O),(ZC,R1E,R2D,R3P),(ZC,R1E,R2D,R3Q),
(ZC,R1E,R2D,R3R),(ZC,R1E,R2E,R3A),(ZC,R1E,R2E,R3B),
(ZC,R1E,R2E,R3C),(ZC,R1E,R2E,R3D),(ZC,R1E,R2E,R3E),
(ZC,R1E,R2E,R3F),(ZC,R1E,R2E,R3G),(ZC,R1E,R2E,R3H),
(ZC,R1E,R2E,R3I),(ZC,R1E,R2E,R3J),(ZC,R1E,R2E,R3K),
(ZC,R1E,R2E,R3L),(ZC,R1E,R2E,R3M),(ZC,R1E,R2E,R3N),
(ZC,R1E,R2E,R3O),(ZC,R1E,R2E,R3P),(ZC,R1E,R2E,R3Q),
(ZC,R1E,R2E,R3R),(ZC,R1E,R2F,R3A),(ZC,R1E,R2F,R3B),
(ZC,R1E,R2F,R3C),(ZC,R1E,R2F,R3D),(ZC,R1E,R2F,R3E),
(ZC,R1E,R2F,R3F),(ZC,R1E,R2F,R3G),(ZC,R1E,R2F,R3H),
(ZC,R1E,R2F,R3I),(ZC,R1E,R2F,R3J),(ZC,R1E,R2F,R3K),
(ZC,R1E,R2F,R3L),(ZC,R1E,R2F,R3M),(ZC,R1E,R2F,R3N),
(ZC,R1E,R2F,R3O),(ZC,R1E,R2F,R3P),(ZC,R1E,R2F,R3Q),
(ZC,R1E,R2F,R3R),(ZC,R1E,R2G,R3A),(ZC,R1E,R2G,R3B),
(ZC,R1E,R2G,R3C),(ZC,R1E,R2G,R3D),(ZC,R1E,R2G,R3E),
(ZC,R1E,R2G,R3F),(ZC,R1E,R2G,R3G),(ZC,R1E,R2G,R3H),
(ZC,R1E,R2G,R3I),(ZC,R1E,R2G,R3J),(ZC,R1E,R2G,R3K),
(ZC,R1E,R2G,R3L),(ZC,R1E,R2G,R3M),(ZC,R1E,R2G,R3N),
(ZC,R1E,R2G,R3O),(ZC,R1E,R2G,R3P),(ZC,R1E,R2G,R3Q),
(ZC,R1E,R2G,R3R),(ZC,R1E,R2H,R3A),(ZC,R1E,R2H,R3B),
(ZC,R1E,R2H,R3C),(ZC,R1E,R2H,R3D),(ZC,R1E,R2H,R3E),
(ZC,R1E,R2H,R3F),(ZC,R1E,R2H,R3G),(ZC,R1E,R2H,R3H),
(ZC,R1E,R2H,R3I),(ZC,R1E,R2H,R3J),(ZC,R1E,R2H,R3K),
(ZC,R1E,R2H,R3L),(ZC,R1E,R2H,R3M),(ZC,R1E,R2H,R3N),
(ZC,R1E,R2H,R3O),(ZC,R1E,R2H,R3P),(ZC,R1E,R2H,R3Q),
(ZC,R1E,R2H,R3R),(ZC,R1E,R2I,R3A),(ZC,R1E,R2I,R3B),
(ZC,R1E,R2I,R3C),(ZC,R1E,R2I,R3D),(ZC,R1E,R2I,R3E),
(ZC,R1E,R2I,R3F),(ZC,R1E,R2I,R3G),(ZC,R1E,R2I,R3H),
(ZC,R1E,R2I,R3I),(ZC,R1E,R2I,R3J),(ZC,R1E,R2I,R3K),
(ZC,R1E,R2I,R3L),(ZC,R1E,R2I,R3M),(ZC,R1E,R2I,R3N),
(ZC,R1E,R2I,R3O),(ZC,R1E,R2I,R3P),(ZC,R1E,R2I,R3Q),
(ZC,R1E,R2I,R3R),(ZC,R1E,R2J,R3A),(ZC,R1E,R2J,R3B),
(ZC,R1E,R2J,R3C),(ZC,R1E,R2J,R3D),(ZC,R1E,R2J,R3E),
(ZC,R1E,R2J,R3F),(ZC,R1E,R2J,R3G),(ZC,R1E,R2J,R3H),
(ZC,R1E,R2J,R3I),(ZC,R1E,R2J,R3J),(ZC,R1E,R2J,R3K),
(ZC,R1E,R2J,R3L),(ZC,R1E,R2J,R3M),(ZC,R1E,R2J,R3N),
(ZC,R1E,R2J,R3O),(ZC,R1E,R2J,R3P),(ZC,R1E,R2J,R3Q),
(ZC,R1E,R2J,R3R),(ZC,R1E,R2K,R3A),(ZC,R1E,R2K,R3B),
(ZC,R1E,R2K,R3C),(ZC,R1E,R2K,R3D),(ZC,R1E,R2K,R3E),
(ZC,R1E,R2K,R3F),(ZC,R1E,R2K,R3G),(ZC,R1E,R2K,R3H),
(ZC,R1E,R2K,R3I),(ZC,R1E,R2K,R3J),(ZC,R1E,R2K,R3K),
(ZC,R1E,R2K,R3L),(ZC,R1E,R2K,R3M),(ZC,R1E,R2K,R3N),
(ZC,R1E,R2K,R3O),(ZC,R1E,R2K,R3P),(ZC,R1E,R2K,R3Q),
(ZC,R1E,R2K,R3R),(ZC,R1E,R2L,R3A),(ZC,R1E,R2L,R3B),
(ZC,R1E,R2L,R3C),(ZC,R1E,R2L,R3D),(ZC,R1E,R2L,R3E),
(ZC,R1E,R2L,R3F),(ZC,R1E,R2L,R3G),(ZC,R1E,R2L,R3H),
(ZC,R1E,R2L,R3I),(ZC,R1E,R2L,R3J),(ZC,R1E,R2L,R3K),
(ZC,R1E,R2L,R3L),(ZC,R1E,R2L,R3M),(ZC,R1E,R2L,R3N),
(ZC,R1E,R2L,R3O),(ZC,R1E,R2L,R3P),(ZC,R1E,R2L,R3Q),
(ZC,R1E,R2L,R3R),(ZC,R1E,R2M,R3A),(ZC,R1E,R2M,R3B),
(ZC,R1E,R2M,R3C),(ZC,R1E,R2M,R3D),(ZC,R1E,R2M,R3E),
(ZC,R1E,R2M,R3F),(ZC,R1E,R2M,R3G),(ZC,R1E,R2M,R3H),
(ZC,R1E,R2M,R3I),(ZC,R1E,R2M,R3J),(ZC,R1E,R2M,R3K),
(ZC,R1E,R2M,R3L),(ZC,R1E,R2M,R3M),(ZC,R1E,R2M,R3N),
(ZC,R1E,R2M,R3O),(ZC,R1E,R2M,R3P),(ZC,R1E,R2M,R3Q),
(ZC,R1E,R2M,R3R),(ZC,R1E,R2N,R3A),(ZC,R1E,R2N,R3B),
(ZC,R1E,R2N,R3C),(ZC,R1E,R2N,R3D),(ZC,R1E,R2N,R3E),
(ZC,R1E,R2N,R3F),(ZC,R1E,R2N,R3G),(ZC,R1E,R2N,R3H),
(ZC,R1E,R2N,R3I),(ZC,R1E,R2N,R3J),(ZC,R1E,R2N,R3K),
(ZC,R1E,R2N,R3L),(ZC,R1E,R2N,R3M),(ZC,R1E,R2N,R3N),
(ZC,R1E,R2N,R3O),(ZC,R1E,R2N,R3P),(ZC,R1E,R2N,R3Q),
(ZC,R1E,R2N,R3R),(ZC,R1F,R2A,R3A),(ZC,R1F,R2A,R3B),
(ZC,R1F,R2A,R3C),(ZC,R1F,R2A,R3D),(ZC,R1F,R2A,R3E),
(ZC,R1F,R2A,R3F),(ZC,R1F,R2A,R3G),(ZC,R1F,R2A,R3H),
(ZC,R1F,R2A,R3I),(ZC,R1F,R2A,R3J),(ZC,R1F,R2A,R3K),
(ZC,R1F,R2A,R3L),(ZC,R1F,R2A,R3M),(ZC,R1F,R2A,R3N),
(ZC,R1F,R2A,R3O),(ZC,R1F,R2A,R3P),(ZC,R1F,R2A,R3Q),
(ZC,R1F,R2A,R3R),(ZC,R1F,R2B,R3A),(ZC,R1F,R2B,R3B),
(ZC,R1F,R2B,R3C),(ZC,R1F,R2B,R3D),(ZC,R1F,R2B,R3E),
(ZC,R1F,R2B,R3F),(ZC,R1F,R2B,R3G),(ZC,R1F,R2B,R3H),
(ZC,R1F,R2B,R3I),(ZC,R1F,R2B,R3J),(ZC,R1F,R2B,R3K),
(ZC,R1F,R2B,R3L),(ZC,R1F,R2B,R3M),(ZC,R1F,R2B,R3N),
(ZC,R1F,R2B,R3O),(ZC,R1F,R2B,R3P),(ZC,R1F,R2B,R3Q),
(ZC,R1F,R2B,R3R),(ZC,R1F,R2C,R3A),(ZC,R1F,R2C,R3B),
(ZC,R1F,R2C,R3C),(ZC,R1F,R2C,R3D),(ZC,R1F,R2C,R3E),
(ZC,R1F,R2C,R3F),(ZC,R1F,R2C,R3G),(ZC,R1F,R2C,R3H),
(ZC,R1F,R2C,R3I),(ZC,R1F,R2C,R3J),(ZC,R1F,R2C,R3K),
(ZC,R1F,R2C,R3L),(ZC,R1F,R2C,R3M),(ZC,R1F,R2C,R3N),
(ZC,R1F,R2C,R3O),(ZC,R1F,R2C,R3P),(ZC,R1F,R2C,R3Q),
(ZC,R1F,R2C,R3R),(ZC,R1F,R2D,R3A),(ZC,R1F,R2D,R3B),
(ZC,R1F,R2D,R3C),(ZC,R1F,R2D,R3D),(ZC,R1F,R2D,R3E),
(ZC,R1F,R2D,R3F),(ZC,R1F,R2D,R3G),(ZC,R1F,R2D,R3H),
(ZC,R1F,R2D,R3I),(ZC,R1F,R2D,R3J),(ZC,R1F,R2D,R3K),
(ZC,R1F,R2D,R3L),(ZC,R1F,R2D,R3M),(ZC,R1F,R2D,R3N),
(ZC,R1F,R2D,R3O),(ZC,R1F,R2D,R3P),(ZC,R1F,R2D,R3Q),
(ZC,R1F,R2D,R3R),(ZC,R1F,R2E,R3A),(ZC,R1F,R2E,R3B),
(ZC,R1F,R2E,R3C),(ZC,R1F,R2E,R3D),(ZC,R1F,R2E,R3E),
(ZC,R1F,R2E,R3F),(ZC,R1F,R2E,R3G),(ZC,R1F,R2E,R3H),
(ZC,R1F,R2E,R3I),(ZC,R1F,R2E,R3J),(ZC,R1F,R2E,R3K),
(ZC,R1F,R2E,R3L),(ZC,R1F,R2E,R3M),(ZC,R1F,R2E,R3N),
(ZC,R1F,R2E,R3O),(ZC,R1F,R2E,R3P),(ZC,R1F,R2E,R3Q),
(ZC,R1F,R2E,R3R),(ZC,R1F,R2F,R3A),(ZC,R1F,R2F,R3B),
(ZC,R1F,R2F,R3C),(ZC,R1F,R2F,R3D),(ZC,R1F,R2F,R3E),
(ZC,R1F,R2F,R3F),(ZC,R1F,R2F,R3G),(ZC,R1F,R2F,R3H),
(ZC,R1F,R2F,R3I),(ZC,R1F,R2F,R3J),(ZC,R1F,R2F,R3K),
(ZC,R1F,R2F,R3L),(ZC,R1F,R2F,R3M),(ZC,R1F,R2F,R3N),
(ZC,R1F,R2F,R3O),(ZC,R1F,R2F,R3P),(ZC,R1F,R2F,R3Q),
(ZC,R1F,R2F,R3R),(ZC,R1F,R2G,R3A),(ZC,R1F,R2G,R3B),
(ZC,R1F,R2G,R3C),(ZC,R1F,R2G,R3D),(ZC,R1F,R2G,R3E),
(ZC,R1F,R2G,R3F),(ZC,R1F,R2G,R3G),(ZC,R1F,R2G,R3H),
(ZC,R1F,R2G,R3I),(ZC,R1F,R2G,R3J),(ZC,R1F,R2G,R3K),
(ZC,R1F,R2G,R3L),(ZC,R1F,R2G,R3M),(ZC,R1F,R2G,R3N),
(ZC,R1F,R2G,R3O),(ZC,R1F,R2G,R3P),(ZC,R1F,R2G,R3Q),
(ZC,R1F,R2G,R3R),(ZC,R1F,R2H,R3A),(ZC,R1F,R2H,R3B),
(ZC,R1F,R2H,R3C),(ZC,R1F,R2H,R3D),(ZC,R1F,R2H,R3E),
(ZC,R1F,R2H,R3F),(ZC,R1F,R2H,R3G),(ZC,R1F,R2H,R3H),
(ZC,R1F,R2H,R3I),(ZC,R1F,R2H,R3J),(ZC,R1F,R2H,R3K),
(ZC,R1F,R2H,R3L),(ZC,R1F,R2H,R3M),(ZC,R1F,R2H,R3N),
(ZC,R1F,R2H,R3O),(ZC,R1F,R2H,R3P),(ZC,R1F,R2H,R3Q),
(ZC,R1F,R2H,R3R),(ZC,R1F,R2I,R3A),(ZC,R1F,R2I,R3B),
(ZC,R1F,R2I,R3C),(ZC,R1F,R2I,R3D),(ZC,R1F,R2I,R3E),
(ZC,R1F,R2I,R3F),(ZC,R1F,R2I,R3G),(ZC,R1F,R2I,R3H),
(ZC,R1F,R2I,R3I),(ZC,R1F,R2I,R3J),(ZC,R1F,R2I,R3K),
(ZC,R1F,R2I,R3L),(ZC,R1F,R2I,R3M),(ZC,R1F,R2I,R3N),
(ZC,R1F,R2I,R3O),(ZC,R1F,R2I,R3P),(ZC,R1F,R2I,R3Q),
(ZC,R1F,R2I,R3R),(ZC,R1F,R2J,R3A),(ZC,R1F,R2J,R3B),
(ZC,R1F,R2J,R3C),(ZC,R1F,R2J,R3D),(ZC,R1F,R2J,R3E),
(ZC,R1F,R2J,R3F),(ZC,R1F,R2J,R3G),(ZC,R1F,R2J,R3H),
(ZC,R1F,R2J,R3I),(ZC,R1F,R2J,R3J),(ZC,R1F,R2J,R3K),
(ZC,R1F,R2J,R3L),(ZC,R1F,R2J,R3M),(ZC,R1F,R2J,R3N),
(ZC,R1F,R2J,R3O),(ZC,R1F,R2J,R3P),(ZC,R1F,R2J,R3Q),
(ZC,R1F,R2J,R3R),(ZC,R1F,R2K,R3A),(ZC,R1F,R2K,R3B),
(ZC,R1F,R2K,R3C),(ZC,R1F,R2K,R3D),(ZC,R1F,R2K,R3E),
(ZC,R1F,R2K,R3F),(ZC,R1F,R2K,R3G),(ZC,R1F,R2K,R3H),
(ZC,R1F,R2K,R3I),(ZC,R1F,R2K,R3J),(ZC,R1F,R2K,R3K),
(ZC,R1F,R2K,R3L),(ZC,R1F,R2K,R3M),(ZC,R1F,R2K,R3N),
(ZC,R1F,R2K,R3O),(ZC,R1F,R2K,R3P),(ZC,R1F,R2K,R3Q),
(ZC,R1F,R2K,R3R),(ZC,R1F,R2L,R3A),(ZC,R1F,R2L,R3B),
(ZC,R1F,R2L,R3C),(ZC,R1F,R2L,R3D),(ZC,R1F,R2L,R3E),
(ZC,R1F,R2L,R3F),(ZC,R1F,R2L,R3G),(ZC,R1F,R2L,R3H),
(ZC,R1F,R2L,R3I),(ZC,R1F,R2L,R3J),(ZC,R1F,R2L,R3K),
(ZC,R1F,R2L,R3L),(ZC,R1F,R2L,R3M),(ZC,R1F,R2L,R3N),
(ZC,R1F,R2L,R3O),(ZC,R1F,R2L,R3P),(ZC,R1F,R2L,R3Q),
(ZC,R1F,R2L,R3R),(ZC,R1F,R2M,R3A),(ZC,R1F,R2M,R3B),
(ZC,R1F,R2M,R3C),(ZC,R1F,R2M,R3D),(ZC,R1F,R2M,R3E),
(ZC,R1F,R2M,R3F),(ZC,R1F,R2M,R3G),(ZC,R1F,R2M,R3H),
(ZC,R1F,R2M,R3I),(ZC,R1F,R2M,R3J),(ZC,R1F,R2M,R3K),
(ZC,R1F,R2M,R3L),(ZC,R1F,R2M,R3M),(ZC,R1F,R2M,R3N),
(ZC,R1F,R2M,R3O),(ZC,R1F,R2M,R3P),(ZC,R1F,R2M,R3Q),
(ZC,R1F,R2M,R3R),(ZC,R1F,R2N,R3A),(ZC,R1F,R2N,R3B),
(ZC,R1F,R2N,R3C),(ZC,R1F,R2N,R3D),(ZC,R1F,R2N,R3E),
(ZC,R1F,R2N,R3F),(ZC,R1F,R2N,R3G),(ZC,R1F,R2N,R3H),
(ZC,R1F,R2N,R3I),(ZC,R1F,R2N,R3J),(ZC,R1F,R2N,R3K),
(ZC,R1F,R2N,R3L),(ZC,R1F,R2N,R3M),(ZC,R1F,R2N,R3N),
(ZC,R1F,R2N,R3O),(ZC,R1F,R2N,R3P),(ZC,R1F,R2N,R3Q),
(ZC,R1F,R2N,R3R),(ZC,R1G,R2A,R3A),(ZC,R1G,R2A,R3B),
(ZC,R1G,R2A,R3C),(ZC,R1G,R2A,R3D),(ZC,R1G,R2A,R3E),
(ZC,R1G,R2A,R3F),(ZC,R1G,R2A,R3G),(ZC,R1G,R2A,R3H),
(ZC,R1G,R2A,R3I),(ZC,R1G,R2A,R3J),(ZC,R1G,R2A,R3K),
(ZC,R1G,R2A,R3L),(ZC,R1G,R2A,R3M),(ZC,R1G,R2A,R3N),
(ZC,R1G,R2A,R3O),(ZC,R1G,R2A,R3P),(ZC,R1G,R2A,R3Q),
(ZC,R1G,R2A,R3R),(ZC,R1G,R2B,R3A),(ZC,R1G,R2B,R3B),
(ZC,R1G,R2B,R3C),(ZC,R1G,R2B,R3D),(ZC,R1G,R2B,R3E),
(ZC,R1G,R2B,R3F),(ZC,R1G,R2B,R3G),(ZC,R1G,R2B,R3H),
(ZC,R1G,R2B,R3I),(ZC,R1G,R2B,R3J),(ZC,R1G,R2B,R3K),
(ZC,R1G,R2B,R3L),(ZC,R1G,R2B,R3M),(ZC,R1G,R2B,R3N),
(ZC,R1G,R2B,R3O),(ZC,R1G,R2B,R3P),(ZC,R1G,R2B,R3Q),
(ZC,R1G,R2B,R3R),(ZC,R1G,R2C,R3A),(ZC,R1G,R2C,R3B),
(ZC,R1G,R2C,R3C),(ZC,R1G,R2C,R3D),(ZC,R1G,R2C,R3E),
(ZC,R1G,R2C,R3F),(ZC,R1G,R2C,R3G),(ZC,R1G,R2C,R3H),
(ZC,R1G,R2C,R3I),(ZC,R1G,R2C,R3J),(ZC,R1G,R2C,R3K),
(ZC,R1G,R2C,R3L),(ZC,R1G,R2C,R3M),(ZC,R1G,R2C,R3N),
(ZC,R1G,R2C,R3O),(ZC,R1G,R2C,R3P),(ZC,R1G,R2C,R3Q),
(ZC,R1G,R2C,R3R),(ZC,R1G,R2D,R3A),(ZC,R1G,R2D,R3B),
(ZC,R1G,R2D,R3C),(ZC,R1G,R2D,R3D),(ZC,R1G,R2D,R3E),
(ZC,R1G,R2D,R3F),(ZC,R1G,R2D,R3G),(ZC,R1G,R2D,R3H),
(ZC,R1G,R2D,R3I),(ZC,R1G,R2D,R3J),(ZC,R1G,R2D,R3K),
(ZC,R1G,R2D,R3L),(ZC,R1G,R2D,R3M),(ZC,R1G,R2D,R3N),
(ZC,R1G,R2D,R3O),(ZC,R1G,R2D,R3P),(ZC,R1G,R2D,R3Q),
(ZC,R1G,R2D,R3R),(ZC,R1G,R2E,R3A),(ZC,R1G,R2E,R3B),
(ZC,R1G,R2E,R3C),(ZC,R1G,R2E,R3D),(ZC,R1G,R2E,R3E),
(ZC,R1G,R2E,R3F),(ZC,R1G,R2E,R3G),(ZC,R1G,R2E,R3H),
(ZC,R1G,R2E,R3I),(ZC,R1G,R2E,R3J),(ZC,R1G,R2E,R3K),
(ZC,R1G,R2E,R3L),(ZC,R1G,R2E,R3M),(ZC,R1G,R2E,R3N),
(ZC,R1G,R2E,R3O),(ZC,R1G,R2E,R3P),(ZC,R1G,R2E,R3Q),
(ZC,R1G,R2E,R3R),(ZC,R1G,R2F,R3A),(ZC,R1G,R2F,R3B),
(ZC,R1G,R2F,R3C),(ZC,R1G,R2F,R3D),(ZC,R1G,R2F,R3E),
(ZC,R1G,R2F,R3F),(ZC,R1G,R2F,R3G),(ZC,R1G,R2F,R3H),
(ZC,R1G,R2F,R3I),(ZC,R1G,R2F,R3J),(ZC,R1G,R2F,R3K),
(ZC,R1G,R2F,R3L),(ZC,R1G,R2F,R3M),(ZC,R1G,R2F,R3N),
(ZC,R1G,R2F,R3O),(ZC,R1G,R2F,R3P),(ZC,R1G,R2F,R3Q),
(ZC,R1G,R2F,R3R),(ZC,R1G,R2G,R3A),(ZC,R1G,R2G,R3B),
(ZC,R1G,R2G,R3C),(ZC,R1G,R2G,R3D),(ZC,R1G,R2G,R3E),
(ZC,R1G,R2G,R3F),(ZC,R1G,R2G,R3G),(ZC,R1G,R2G,R3H),
(ZC,R1G,R2G,R3I),(ZC,R1G,R2G,R3J),(ZC,R1G,R2G,R3K),
(ZC,R1G,R2G,R3L),(ZC,R1G,R2G,R3M),(ZC,R1G,R2G,R3N),
(ZC,R1G,R2G,R3O),(ZC,R1G,R2G,R3P),(ZC,R1G,R2G,R3Q),
(ZC,R1G,R2G,R3R),(ZC,R1G,R2H,R3A),(ZC,R1G,R2H,R3B),
(ZC,R1G,R2H,R3C),(ZC,R1G,R2H,R3D),(ZC,R1G,R2H,R3E),
(ZC,R1G,R2H,R3F),(ZC,R1G,R2H,R3G),(ZC,R1G,R2H,R3H),
(ZC,R1G,R2H,R3I),(ZC,R1G,R2H,R3J),(ZC,R1G,R2H,R3K),
(ZC,R1G,R2H,R3L),(ZC,R1G,R2H,R3M),(ZC,R1G,R2H,R3N),
(ZC,R1G,R2H,R3O),(ZC,R1G,R2H,R3P),(ZC,R1G,R2H,R3Q),
(ZC,R1G,R2H,R3R),(ZC,R1G,R2I,R3A),(ZC,R1G,R2I,R3B),
(ZC,R1G,R2I,R3C),(ZC,R1G,R2I,R3D),(ZC,R1G,R2I,R3E),
(ZC,R1G,R2I,R3F),(ZC,R1G,R2I,R3G),(ZC,R1G,R2I,R3H),
(ZC,R1G,R2I,R3I),(ZC,R1G,R2I,R3J),(ZC,R1G,R2I,R3K),
(ZC,R1G,R2I,R3L),(ZC,R1G,R2I,R3M),(ZC,R1G,R2I,R3N),
(ZC,R1G,R2I,R3O),(ZC,R1G,R2I,R3P),(ZC,R1G,R2I,R3Q),
(ZC,R1G,R2I,R3R),(ZC,R1G,R2J,R3A),(ZC,R1G,R2J,R3B),
(ZC,R1G,R2J,R3C),(ZC,R1G,R2J,R3D),(ZC,R1G,R2J,R3E),
(ZC,R1G,R2J,R3F),(ZC,R1G,R2J,R3G),(ZC,R1G,R2J,R3H),
(ZC,R1G,R2J,R3I),(ZC,R1G,R2J,R3J),(ZC,R1G,R2J,R3K),
(ZC,R1G,R2J,R3L),(ZC,R1G,R2J,R3M),(ZC,R1G,R2J,R3N),
(ZC,R1G,R2J,R3O),(ZC,R1G,R2J,R3P),(ZC,R1G,R2J,R3Q),
(ZC,R1G,R2J,R3R),(ZC,R1G,R2K,R3A),(ZC,R1G,R2K,R3B),
(ZC,R1G,R2K,R3C),(ZC,R1G,R2K,R3D),(ZC,R1G,R2K,R3E),
(ZC,R1G,R2K,R3F),(ZC,R1G,R2K,R3G),(ZC,R1G,R2K,R3H),
(ZC,R1G,R2K,R3I),(ZC,R1G,R2K,R3J),(ZC,R1G,R2K,R3K),
(ZC,R1G,R2K,R3L),(ZC,R1G,R2K,R3M),(ZC,R1G,R2K,R3N),
(ZC,R1G,R2K,R3O),(ZC,R1G,R2K,R3P),(ZC,R1G,R2K,R3Q),
(ZC,R1G,R2K,R3R),(ZC,R1G,R2L,R3A),(ZC,R1G,R2L,R3B),
(ZC,R1G,R2L,R3C),(ZC,R1G,R2L,R3D),(ZC,R1G,R2L,R3E),
(ZC,R1G,R2L,R3F),(ZC,R1G,R2L,R3G),(ZC,R1G,R2L,R3H),
(ZC,R1G,R2L,R3I),(ZC,R1G,R2L,R3J),(ZC,R1G,R2L,R3K),
(ZC,R1G,R2L,R3L),(ZC,R1G,R2L,R3M),(ZC,R1G,R2L,R3N),
(ZC,R1G,R2L,R3O),(ZC,R1G,R2L,R3P),(ZC,R1G,R2L,R3Q),
(ZC,R1G,R2L,R3R),(ZC,R1G,R2M,R3A),(ZC,R1G,R2M,R3B),
(ZC,R1G,R2M,R3C),(ZC,R1G,R2M,R3D),(ZC,R1G,R2M,R3E),
(ZC,R1G,R2M,R3F),(ZC,R1G,R2M,R3G),(ZC,R1G,R2M,R3H),
(ZC,R1G,R2M,R3I),(ZC,R1G,R2M,R3J),(ZC,R1G,R2M,R3K),
(ZC,R1G,R2M,R3L),(ZC,R1G,R2M,R3M),(ZC,R1G,R2M,R3N),
(ZC,R1G,R2M,R3O),(ZC,R1G,R2M,R3P),(ZC,R1G,R2M,R3Q),
(ZC,R1G,R2M,R3R),(ZC,R1G,R2N,R3A),(ZC,R1G,R2N,R3B),
(ZC,R1G,R2N,R3C),(ZC,R1G,R2N,R3D),(ZC,R1G,R2N,R3E),
(ZC,R1G,R2N,R3F),(ZC,R1G,R2N,R3G),(ZC,R1G,R2N,R3H),
(ZC,R1G,R2N,R3I),(ZC,R1G,R2N,R3J),(ZC,R1G,R2N,R3K),
(ZC,R1G,R2N,R3L),(ZC,R1G,R2N,R3M),(ZC,R1G,R2N,R3N),
(ZC,R1G,R2N,R3O),(ZC,R1G,R2N,R3P),(ZC,R1G,R2N,R3Q),
(ZC,R1G,R2N,R3R),(ZC,R1H,R2A,R3A),(ZC,R1H,R2A,R3B),
(ZC,R1H,R2A,R3C),(ZC,R1H,R2A,R3D),(ZC,R1H,R2A,R3E),
(ZC,R1H,R2A,R3F),(ZC,R1H,R2A,R3G),(ZC,R1H,R2A,R3H),
(ZC,R1H,R2A,R3I),(ZC,R1H,R2A,R3J),(ZC,R1H,R2A,R3K),
(ZC,R1H,R2A,R3L),(ZC,R1H,R2A,R3M),(ZC,R1H,R2A,R3N),
(ZC,R1H,R2A,R3O),(ZC,R1H,R2A,R3P),(ZC,R1H,R2A,R3Q),
(ZC,R1H,R2A,R3R),(ZC,R1H,R2B,R3A),(ZC,R1H,R2B,R3B),
(ZC,R1H,R2B,R3C),(ZC,R1H,R2B,R3D),(ZC,R1H,R2B,R3E),
(ZC,R1H,R2B,R3F),(ZC,R1H,R2B,R3G),(ZC,R1H,R2B,R3H),
(ZC,R1H,R2B,R3I),(ZC,R1H,R2B,R3J),(ZC,R1H,R2B,R3K),
(ZC,R1H,R2B,R3L),(ZC,R1H,R2B,R3M),(ZC,R1H,R2B,R3N),
(ZC,R1H,R2B,R3O),(ZC,R1H,R2B,R3P),(ZC,R1H,R2B,R3Q),
(ZC,R1H,R2B,R3R),(ZC,R1H,R2C,R3A),(ZC,R1H,R2C,R3B),
(ZC,R1H,R2C,R3C),(ZC,R1H,R2C,R3D),(ZC,R1H,R2C,R3E),
(ZC,R1H,R2C,R3F),(ZC,R1H,R2C,R3G),(ZC,R1H,R2C,R3H),
(ZC,R1H,R2C,R3I),(ZC,R1H,R2C,R3J),(ZC,R1H,R2C,R3K),
(ZC,R1H,R2C,R3L),(ZC,R1H,R2C,R3M),(ZC,R1H,R2C,R3N),
(ZC,R1H,R2C,R3O),(ZC,R1H,R2C,R3P),(ZC,R1H,R2C,R3Q),
(ZC,R1H,R2C,R3R),(ZC,R1H,R2D,R3A),(ZC,R1H,R2D,R3B),
(ZC,R1H,R2D,R3C),(ZC,R1H,R2D,R3D),(ZC,R1H,R2D,R3E),
(ZC,R1H,R2D,R3F),(ZC,R1H,R2D,R3G),(ZC,R1H,R2D,R3H),
(ZC,R1H,R2D,R3I),(ZC,R1H,R2D,R3J),(ZC,R1H,R2D,R3K),
(ZC,R1H,R2D,R3L),(ZC,R1H,R2D,R3M),(ZC,R1H,R2D,R3N),
(ZC,R1H,R2D,R3O),(ZC,R1H,R2D,R3P),(ZC,R1H,R2D,R3Q),
(ZC,R1H,R2D,R3R),(ZC,R1H,R2E,R3A),(ZC,R1H,R2E,R3B),
(ZC,R1H,R2E,R3C),(ZC,R1H,R2E,R3D),(ZC,R1H,R2E,R3E),
(ZC,R1H,R2E,R3F),(ZC,R1H,R2E,R3G),(ZC,R1H,R2E,R3H),
(ZC,R1H,R2E,R3I),(ZC,R1H,R2E,R3J),(ZC,R1H,R2E,R3K),
(ZC,R1H,R2E,R3L),(ZC,R1H,R2E,R3M),(ZC,R1H,R2E,R3N),
(ZC,R1H,R2E,R3O),(ZC,R1H,R2E,R3P),(ZC,R1H,R2E,R3Q),
(ZC,R1H,R2E,R3R),(ZC,R1H,R2F,R3A),(ZC,R1H,R2F,R3B),
(ZC,R1H,R2F,R3C),(ZC,R1H,R2F,R3D),(ZC,R1H,R2F,R3E),
(ZC,R1H,R2F,R3F),(ZC,R1H,R2F,R3G),(ZC,R1H,R2F,R3H),
(ZC,R1H,R2F,R3I),(ZC,R1H,R2F,R3J),(ZC,R1H,R2F,R3K),
(ZC,R1H,R2F,R3L),(ZC,R1H,R2F,R3M),(ZC,R1H,R2F,R3N),
(ZC,R1H,R2F,R3O),(ZC,R1H,R2F,R3P),(ZC,R1H,R2F,R3Q),
(ZC,R1H,R2F,R3R),(ZC,R1H,R2G,R3A),(ZC,R1H,R2G,R3B),
(ZC,R1H,R2G,R3C),(ZC,R1H,R2G,R3D),(ZC,R1H,R2G,R3E),
(ZC,R1H,R2G,R3F),(ZC,R1H,R2G,R3G),(ZC,R1H,R2G,R3H),
(ZC,R1H,R2G,R3I),(ZC,R1H,R2G,R3J),(ZC,R1H,R2G,R3K),
(ZC,R1H,R2G,R3L),(ZC,R1H,R2G,R3M),(ZC,R1H,R2G,R3N),
(ZC,R1H,R2G,R3O),(ZC,R1H,R2G,R3P),(ZC,R1H,R2G,R3Q),
(ZC,R1H,R2G,R3R),(ZC,R1H,R2H,R3A),(ZC,R1H,R2H,R3B),
(ZC,R1H,R2H,R3C),(ZC,R1H,R2H,R3D),(ZC,R1H,R2H,R3E),
(ZC,R1H,R2H,R3F),(ZC,R1H,R2H,R3G),(ZC,R1H,R2H,R3H),
(ZC,R1H,R2H,R3I),(ZC,R1H,R2H,R3J),(ZC,R1H,R2H,R3K),
(ZC,R1H,R2H,R3L),(ZC,R1H,R2H,R3M),(ZC,R1H,R2H,R3N),
(ZC,R1H,R2H,R3O),(ZC,R1H,R2H,R3P),(ZC,R1H,R2H,R3Q),
(ZC,R1H,R2H,R3R),(ZC,R1H,R2I,R3A),(ZC,R1H,R2I,R3B),
(ZC,R1H,R2I,R3C),(ZC,R1H,R2I,R3D),(ZC,R1H,R2I,R3E),
(ZC,R1H,R2I,R3F),(ZC,R1H,R2I,R3G),(ZC,R1H,R2I,R3H),
(ZC,R1H,R2I,R3I),(ZC,R1H,R2I,R3J),(ZC,R1H,R2I,R3K),
(ZC,R1H,R2I,R3L),(ZC,R1H,R2I,R3M),(ZC,R1H,R2I,R3N),
(ZC,R1H,R2I,R3O),(ZC,R1H,R2I,R3P),(ZC,R1H,R2I,R3Q),
(ZC,R1H,R2I,R3R),(ZC,R1H,R2J,R3A),(ZC,R1H,R2J,R3B),
(ZC,R1H,R2J,R3C),(ZC,R1H,R2J,R3D),(ZC,R1H,R2J,R3E),
(ZC,R1H,R2J,R3F),(ZC,R1H,R2J,R3G),(ZC,R1H,R2J,R3H),
(ZC,R1H,R2J,R3I),(ZC,R1H,R2J,R3J),(ZC,R1H,R2J,R3K),
(ZC,R1H,R2J,R3L),(ZC,R1H,R2J,R3M),(ZC,R1H,R2J,R3N),
(ZC,R1H,R2J,R3O),(ZC,R1H,R2J,R3P),(ZC,R1H,R2J,R3Q),
(ZC,R1H,R2J,R3R),(ZC,R1H,R2K,R3A),(ZC,R1H,R2K,R3B),
(ZC,R1H,R2K,R3C),(ZC,R1H,R2K,R3D),(ZC,R1H,R2K,R3E),
(ZC,R1H,R2K,R3F),(ZC,R1H,R2K,R3G),(ZC,R1H,R2K,R3H),
(ZC,R1H,R2K,R3I),(ZC,R1H,R2K,R3J),(ZC,R1H,R2K,R3K),
(ZC,R1H,R2K,R3L),(ZC,R1H,R2K,R3M),(ZC,R1H,R2K,R3N),
(ZC,R1H,R2K,R3O),(ZC,R1H,R2K,R3P),(ZC,R1H,R2K,R3Q),
(ZC,R1H,R2K,R3R),(ZC,R1H,R2L,R3A),(ZC,R1H,R2L,R3B),
(ZC,R1H,R2L,R3C),(ZC,R1H,R2L,R3D),(ZC,R1H,R2L,R3E),
(ZC,R1H,R2L,R3F),(ZC,R1H,R2L,R3G),(ZC,R1H,R2L,R3H),
(ZC,R1H,R2L,R3I),(ZC,R1H,R2L,R3J),(ZC,R1H,R2L,R3K),
(ZC,R1H,R2L,R3L),(ZC,R1H,R2L,R3M),(ZC,R1H,R2L,R3N),
(ZC,R1H,R2L,R3O),(ZC,R1H,R2L,R3P),(ZC,R1H,R2L,R3Q),
(ZC,R1H,R2L,R3R),(ZC,R1H,R2M,R3A),(ZC,R1H,R2M,R3B),
(ZC,R1H,R2M,R3C),(ZC,R1H,R2M,R3D),(ZC,R1H,R2M,R3E),
(ZC,R1H,R2M,R3F),(ZC,R1H,R2M,R3G),(ZC,R1H,R2M,R3H),
(ZC,R1H,R2M,R3I),(ZC,R1H,R2M,R3J),(ZC,R1H,R2M,R3K),
(ZC,R1H,R2M,R3L),(ZC,R1H,R2M,R3M),(ZC,R1H,R2M,R3N),
(ZC,R1H,R2M,R3O),(ZC,R1H,R2M,R3P),(ZC,R1H,R2M,R3Q),
(ZC,R1H,R2M,R3R),(ZC,R1H,R2N,R3A),(ZC,R1H,R2N,R3B),
(ZC,R1H,R2N,R3C),(ZC,R1H,R2N,R3D),(ZC,R1H,R2N,R3E),
(ZC,R1H,R2N,R3F),(ZC,R1H,R2N,R3G),(ZC,R1H,R2N,R3H),
(ZC,R1H,R2N,R3I),(ZC,R1H,R2N,R3J),(ZC,R1H,R2N,R3K),
(ZC,R1H,R2N,R3L),(ZC,R1H,R2N,R3M),(ZC,R1H,R2N,R3N),
(ZC,R1H,R2N,R3O),(ZC,R1H,R2N,R3P),(ZC,R1H,R2N,R3Q),
(ZC,R1H,R2N,R3R),(ZC,R1I,R2A,R3A),(ZC,R1I,R2A,R3B),
(ZC,R1I,R2A,R3C),(ZC,R1I,R2A,R3D),(ZC,R1I,R2A,R3E),
(ZC,R1I,R2A,R3F),(ZC,R1I,R2A,R3G),(ZC,R1I,R2A,R3H),
(ZC,R1I,R2A,R3I),(ZC,R1I,R2A,R3J),(ZC,R1I,R2A,R3K),
(ZC,R1I,R2A,R3L),(ZC,R1I,R2A,R3M),(ZC,R1I,R2A,R3N),
(ZC,R1I,R2A,R3O),(ZC,R1I,R2A,R3P),(ZC,R1I,R2A,R3Q),
(ZC,R1I,R2A,R3R),(ZC,R1I,R2B,R3A),(ZC,R1I,R2B,R3B),
(ZC,R1I,R2B,R3C),(ZC,R1I,R2B,R3D),(ZC,R1I,R2B,R3E),
(ZC,R1I,R2B,R3F),(ZC,R1I,R2B,R3G),(ZC,R1I,R2B,R3H),
(ZC,R1I,R2B,R3I),(ZC,R1I,R2B,R3J),(ZC,R1I,R2B,R3K),
(ZC,R1I,R2B,R3L),(ZC,R1I,R2B,R3M),(ZC,R1I,R2B,R3N),
(ZC,R1I,R2B,R3O),(ZC,R1I,R2B,R3P),(ZC,R1I,R2B,R3Q),
(ZC,R1I,R2B,R3R),(ZC,R1I,R2C,R3A),(ZC,R1I,R2C,R3B),
(ZC,R1I,R2C,R3C),(ZC,R1I,R2C,R3D),(ZC,R1I,R2C,R3E),
(ZC,R1I,R2C,R3F),(ZC,R1I,R2C,R3G),(ZC,R1I,R2C,R3H),
(ZC,R1I,R2C,R3I),(ZC,R1I,R2C,R3J),(ZC,R1I,R2C,R3K),
(ZC,R1I,R2C,R3L),(ZC,R1I,R2C,R3M),(ZC,R1I,R2C,R3N),
(ZC,R1I,R2C,R3O),(ZC,R1I,R2C,R3P),(ZC,R1I,R2C,R3Q),
(ZC,R1I,R2C,R3R),(ZC,R1I,R2D,R3A),(ZC,R1I,R2D,R3B),
(ZC,R1I,R2D,R3C),(ZC,R1I,R2D,R3D),(ZC,R1I,R2D,R3E),
(ZC,R1I,R2D,R3F),(ZC,R1I,R2D,R3G),(ZC,R1I,R2D,R3H),
(ZC,R1I,R2D,R3I),(ZC,R1I,R2D,R3J),(ZC,R1I,R2D,R3K),
(ZC,R1I,R2D,R3L),(ZC,R1I,R2D,R3M),(ZC,R1I,R2D,R3N),
(ZC,R1I,R2D,R3O),(ZC,R1I,R2D,R3P),(ZC,R1I,R2D,R3Q),
(ZC,R1I,R2D,R3R),(ZC,R1I,R2E,R3A),(ZC,R1I,R2E,R3B),
(ZC,R1I,R2E,R3C),(ZC,R1I,R2E,R3D),(ZC,R1I,R2E,R3E),
(ZC,R1I,R2E,R3F),(ZC,R1I,R2E,R3G),(ZC,R1I,R2E,R3H),
(ZC,R1I,R2E,R3I),(ZC,R1I,R2E,R3J),(ZC,R1I,R2E,R3K),
(ZC,R1I,R2E,R3L),(ZC,R1I,R2E,R3M),(ZC,R1I,R2E,R3N),
(ZC,R1I,R2E,R3O),(ZC,R1I,R2E,R3P),(ZC,R1I,R2E,R3Q),
(ZC,R1I,R2E,R3R),(ZC,R1I,R2F,R3A),(ZC,R1I,R2F,R3B),
(ZC,R1I,R2F,R3C),(ZC,R1I,R2F,R3D),(ZC,R1I,R2F,R3E),
(ZC,R1I,R2F,R3F),(ZC,R1I,R2F,R3G),(ZC,R1I,R2F,R3H),
(ZC,R1I,R2F,R3I),(ZC,R1I,R2F,R3J),(ZC,R1I,R2F,R3K),
(ZC,R1I,R2F,R3L),(ZC,R1I,R2F,R3M),(ZC,R1I,R2F,R3N),
(ZC,R1I,R2F,R3O),(ZC,R1I,R2F,R3P),(ZC,R1I,R2F,R3Q),
(ZC,R1I,R2F,R3R),(ZC,R1I,R2G,R3A),(ZC,R1I,R2G,R3B),
(ZC,R1I,R2G,R3C),(ZC,R1I,R2G,R3D),(ZC,R1I,R2G,R3E),
(ZC,R1I,R2G,R3F),(ZC,R1I,R2G,R3G),(ZC,R1I,R2G,R3H),
(ZC,R1I,R2G,R3I),(ZC,R1I,R2G,R3J),(ZC,R1I,R2G,R3K),
(ZC,R1I,R2G,R3L),(ZC,R1I,R2G,R3M),(ZC,R1I,R2G,R3N),
(ZC,R1I,R2G,R3O),(ZC,R1I,R2G,R3P),(ZC,R1I,R2G,R3Q),
(ZC,R1I,R2G,R3R),(ZC,R1I,R2H,R3A),(ZC,R1I,R2H,R3B),
(ZC,R1I,R2H,R3C),(ZC,R1I,R2H,R3D),(ZC,R1I,R2H,R3E),
(ZC,R1I,R2H,R3F),(ZC,R1I,R2H,R3G),(ZC,R1I,R2H,R3H),
(ZC,R1I,R2H,R3I),(ZC,R1I,R2H,R3J),(ZC,R1I,R2H,R3K),
(ZC,R1I,R2H,R3L),(ZC,R1I,R2H,R3M),(ZC,R1I,R2H,R3N),
(ZC,R1I,R2H,R3O),(ZC,R1I,R2H,R3P),(ZC,R1I,R2H,R3Q),
(ZC,R1I,R2H,R3R),(ZC,R1I,R2I,R3A),(ZC,R1I,R2I,R3B),
(ZC,R1I,R2I,R3C),(ZC,R1I,R2I,R3D),(ZC,R1I,R2I,R3E),
(ZC,R1I,R2I,R3F),(ZC,R1I,R2I,R3G),(ZC,R1I,R2I,R3H),
(ZC,R1I,R2I,R3I),(ZC,R1I,R2I,R3J),(ZC,R1I,R2I,R3K),
(ZC,R1I,R2I,R3L),(ZC,R1I,R2I,R3M),(ZC,R1I,R2I,R3N),
(ZC,R1I,R2I,R3O),(ZC,R1I,R2I,R3P),(ZC,R1I,R2I,R3Q),
(ZC,R1I,R2I,R3R),(ZC,R1I,R2J,R3A),(ZC,R1I,R2J,R3B),
(ZC,R1I,R2J,R3C),(ZC,R1I,R2J,R3D),(ZC,R1I,R2J,R3E),
(ZC,R1I,R2J,R3F),(ZC,R1I,R2J,R3G),(ZC,R1I,R2J,R3H),
(ZC,R1I,R2J,R3I),(ZC,R1I,R2J,R3J),(ZC,R1I,R2J,R3K),
(ZC,R1I,R2J,R3L),(ZC,R1I,R2J,R3M),(ZC,R1I,R2J,R3N),
(ZC,R1I,R2J,R3O),(ZC,R1I,R2J,R3P),(ZC,R1I,R2J,R3Q),
(ZC,R1I,R2J,R3R),(ZC,R1I,R2K,R3A),(ZC,R1I,R2K,R3B),
(ZC,R1I,R2K,R3C),(ZC,R1I,R2K,R3D),(ZC,R1I,R2K,R3E),
(ZC,R1I,R2K,R3F),(ZC,R1I,R2K,R3G),(ZC,R1I,R2K,R3H),
(ZC,R1I,R2K,R3I),(ZC,R1I,R2K,R3J),(ZC,R1I,R2K,R3K),
(ZC,R1I,R2K,R3L),(ZC,R1I,R2K,R3M),(ZC,R1I,R2K,R3N),
(ZC,R1I,R2K,R3O),(ZC,R1I,R2K,R3P),(ZC,R1I,R2K,R3Q),
(ZC,R1I,R2K,R3R),(ZC,R1I,R2L,R3A),(ZC,R1I,R2L,R3B),
(ZC,R1I,R2L,R3C),(ZC,R1I,R2L,R3D),(ZC,R1I,R2L,R3E),
(ZC,R1I,R2L,R3F),(ZC,R1I,R2L,R3G),(ZC,R1I,R2L,R3H),
(ZC,R1I,R2L,R3I),(ZC,R1I,R2L,R3J),(ZC,R1I,R2L,R3K),
(ZC,R1I,R2L,R3L),(ZC,R1I,R2L,R3M),(ZC,R1I,R2L,R3N),
(ZC,R1I,R2L,R3O),(ZC,R1I,R2L,R3P),(ZC,R1I,R2L,R3Q),
(ZC,R1I,R2L,R3R),(ZC,R1I,R2M,R3A),(ZC,R1I,R2M,R3B),
(ZC,R1I,R2M,R3C),(ZC,R1I,R2M,R3D),(ZC,R1I,R2M,R3E),
(ZC,R1I,R2M,R3F),(ZC,R1I,R2M,R3G),(ZC,R1I,R2M,R3H),
(ZC,R1I,R2M,R3I),(ZC,R1I,R2M,R3J),(ZC,R1I,R2M,R3K),
(ZC,R1I,R2M,R3L),(ZC,R1I,R2M,R3M),(ZC,R1I,R2M,R3N),
(ZC,R1I,R2M,R3O),(ZC,R1I,R2M,R3P),(ZC,R1I,R2M,R3Q),
(ZC,R1I,R2M,R3R),(ZC,R1I,R2N,R3A),(ZC,R1I,R2N,R3B),
(ZC,R1I,R2N,R3C),(ZC,R1I,R2N,R3D),(ZC,R1I,R2N,R3E),
(ZC,R1I,R2N,R3F),(ZC,R1I,R2N,R3G),(ZC,R1I,R2N,R3H),
(ZC,R1I,R2N,R3I),(ZC,R1I,R2N,R3J),(ZC,R1I,R2N,R3K),
(ZC,R1I,R2N,R3L),(ZC,R1I,R2N,R3M),(ZC,R1I,R2N,R3N),
(ZC,R1I,R2N,R3O),(ZC,R1I,R2N,R3P),(ZC,R1I,R2N,R3Q),
(ZC,R1I,R2N,R3R),(ZC,R1J,R2A,R3A),(ZC,R1J,R2A,R3B),
(ZC,R1J,R2A,R3C),(ZC,R1J,R2A,R3D),(ZC,R1J,R2A,R3E),
(ZC,R1J,R2A,R3F),(ZC,R1J,R2A,R3G),(ZC,R1J,R2A,R3H),
(ZC,R1J,R2A,R3I),(ZC,R1J,R2A,R3J),(ZC,R1J,R2A,R3K),
(ZC,R1J,R2A,R3L),(ZC,R1J,R2A,R3M),(ZC,R1J,R2A,R3N),
(ZC,R1J,R2A,R3O),(ZC,R1J,R2A,R3P),(ZC,R1J,R2A,R3Q),
(ZC,R1J,R2A,R3R),(ZC,R1J,R2B,R3A),(ZC,R1J,R2B,R3B),
(ZC,R1J,R2B,R3C),(ZC,R1J,R2B,R3D),(ZC,R1J,R2B,R3E),
(ZC,R1J,R2B,R3F),(ZC,R1J,R2B,R3G),(ZC,R1J,R2B,R3H),
(ZC,R1J,R2B,R3I),(ZC,R1J,R2B,R3J),(ZC,R1J,R2B,R3K),
(ZC,R1J,R2B,R3L),(ZC,R1J,R2B,R3M),(ZC,R1J,R2B,R3N),
(ZC,R1J,R2B,R3O),(ZC,R1J,R2B,R3P),(ZC,R1J,R2B,R3Q),
(ZC,R1J,R2B,R3R),(ZC,R1J,R2C,R3A),(ZC,R1J,R2C,R3B),
(ZC,R1J,R2C,R3C),(ZC,R1J,R2C,R3D),(ZC,R1J,R2C,R3E),
(ZC,R1J,R2C,R3F),(ZC,R1J,R2C,R3G),(ZC,R1J,R2C,R3H),
(ZC,R1J,R2C,R3I),(ZC,R1J,R2C,R3J),(ZC,R1J,R2C,R3K),
(ZC,R1J,R2C,R3L),(ZC,R1J,R2C,R3M),(ZC,R1J,R2C,R3N),
(ZC,R1J,R2C,R3O),(ZC,R1J,R2C,R3P),(ZC,R1J,R2C,R3Q),
(ZC,R1J,R2C,R3R),(ZC,R1J,R2D,R3A),(ZC,R1J,R2D,R3B),
(ZC,R1J,R2D,R3C),(ZC,R1J,R2D,R3D),(ZC,R1J,R2D,R3E),
(ZC,R1J,R2D,R3F),(ZC,R1J,R2D,R3G),(ZC,R1J,R2D,R3H),
(ZC,R1J,R2D,R3I),(ZC,R1J,R2D,R3J),(ZC,R1J,R2D,R3K),
(ZC,R1J,R2D,R3L),(ZC,R1J,R2D,R3M),(ZC,R1J,R2D,R3N),
(ZC,R1J,R2D,R3O),(ZC,R1J,R2D,R3P),(ZC,R1J,R2D,R3Q),
(ZC,R1J,R2D,R3R),(ZC,R1J,R2E,R3A),(ZC,R1J,R2E,R3B),
(ZC,R1J,R2E,R3C),(ZC,R1J,R2E,R3D),(ZC,R1J,R2E,R3E),
(ZC,R1J,R2E,R3F),(ZC,R1J,R2E,R3G),(ZC,R1J,R2E,R3H),
(ZC,R1J,R2E,R3I),(ZC,R1J,R2E,R3J),(ZC,R1J,R2E,R3K),
(ZC,R1J,R2E,R3L),(ZC,R1J,R2E,R3M),(ZC,R1J,R2E,R3N),
(ZC,R1J,R2E,R3O),(ZC,R1J,R2E,R3P),(ZC,R1J,R2E,R3Q),
(ZC,R1J,R2E,R3R),(ZC,R1J,R2F,R3A),(ZC,R1J,R2F,R3B),
(ZC,R1J,R2F,R3C),(ZC,R1J,R2F,R3D),(ZC,R1J,R2F,R3E),
(ZC,R1J,R2F,R3F),(ZC,R1J,R2F,R3G),(ZC,R1J,R2F,R3H),
(ZC,R1J,R2F,R3I),(ZC,R1J,R2F,R3J),(ZC,R1J,R2F,R3K),
(ZC,R1J,R2F,R3L),(ZC,R1J,R2F,R3M),(ZC,R1J,R2F,R3N),
(ZC,R1J,R2F,R3O),(ZC,R1J,R2F,R3P),(ZC,R1J,R2F,R3Q),
(ZC,R1J,R2F,R3R),(ZC,R1J,R2G,R3A),(ZC,R1J,R2G,R3B),
(ZC,R1J,R2G,R3C),(ZC,R1J,R2G,R3D),(ZC,R1J,R2G,R3E),
(ZC,R1J,R2G,R3F),(ZC,R1J,R2G,R3G),(ZC,R1J,R2G,R3H),
(ZC,R1J,R2G,R3I),(ZC,R1J,R2G,R3J),(ZC,R1J,R2G,R3K),
(ZC,R1J,R2G,R3L),(ZC,R1J,R2G,R3M),(ZC,R1J,R2G,R3N),
(ZC,R1J,R2G,R3O),(ZC,R1J,R2G,R3P),(ZC,R1J,R2G,R3Q),
(ZC,R1J,R2G,R3R),(ZC,R1J,R2H,R3A),(ZC,R1J,R2H,R3B),
(ZC,R1J,R2H,R3C),(ZC,R1J,R2H,R3D),(ZC,R1J,R2H,R3E),
(ZC,R1J,R2H,R3F),(ZC,R1J,R2H,R3G),(ZC,R1J,R2H,R3H),
(ZC,R1J,R2H,R3I),(ZC,R1J,R2H,R3J),(ZC,R1J,R2H,R3K),
(ZC,R1J,R2H,R3L),(ZC,R1J,R2H,R3M),(ZC,R1J,R2H,R3N),
(ZC,R1J,R2H,R3O),(ZC,R1J,R2H,R3P),(ZC,R1J,R2H,R3Q),
(ZC,R1J,R2H,R3R),(ZC,R1J,R2I,R3A),(ZC,R1J,R2I,R3B),
(ZC,R1J,R2I,R3C),(ZC,R1J,R2I,R3D),(ZC,R1J,R2I,R3E),
(ZC,R1J,R2I,R3F),(ZC,R1J,R2I,R3G),(ZC,R1J,R2I,R3H),
(ZC,R1J,R2I,R3I),(ZC,R1J,R2I,R3J),(ZC,R1J,R2I,R3K),
(ZC,R1J,R2I,R3L),(ZC,R1J,R2I,R3M),(ZC,R1J,R2I,R3N),
(ZC,R1J,R2I,R3O),(ZC,R1J,R2I,R3P),(ZC,R1J,R2I,R3Q),
(ZC,R1J,R2I,R3R),(ZC,R1J,R2J,R3A),(ZC,R1J,R2J,R3B),
(ZC,R1J,R2J,R3C),(ZC,R1J,R2J,R3D),(ZC,R1J,R2J,R3E),
(ZC,R1J,R2J,R3F),(ZC,R1J,R2J,R3G),(ZC,R1J,R2J,R3H),
(ZC,R1J,R2J,R3I),(ZC,R1J,R2J,R3J),(ZC,R1J,R2J,R3K),
(ZC,R1J,R2J,R3L),(ZC,R1J,R2J,R3M),(ZC,R1J,R2J,R3N),
(ZC,R1J,R2J,R3O),(ZC,R1J,R2J,R3P),(ZC,R1J,R2J,R3Q),
(ZC,R1J,R2J,R3R),(ZC,R1J,R2K,R3A),(ZC,R1J,R2K,R3B),
(ZC,R1J,R2K,R3C),(ZC,R1J,R2K,R3D),(ZC,R1J,R2K,R3E),
(ZC,R1J,R2K,R3F),(ZC,R1J,R2K,R3G),(ZC,R1J,R2K,R3H),
(ZC,R1J,R2K,R3I),(ZC,R1J,R2K,R3J),(ZC,R1J,R2K,R3K),
(ZC,R1J,R2K,R3L),(ZC,R1J,R2K,R3M),(ZC,R1J,R2K,R3N),
(ZC,R1J,R2K,R3O),(ZC,R1J,R2K,R3P),(ZC,R1J,R2K,R3Q),
(ZC,R1J,R2K,R3R),(ZC,R1J,R2L,R3A),(ZC,R1J,R2L,R3B),
(ZC,R1J,R2L,R3C),(ZC,R1J,R2L,R3D),(ZC,R1J,R2L,R3E),
(ZC,R1J,R2L,R3F),(ZC,R1J,R2L,R3G),(ZC,R1J,R2L,R3H),
(ZC,R1J,R2L,R3I),(ZC,R1J,R2L,R3J),(ZC,R1J,R2L,R3K),
(ZC,R1J,R2L,R3L),(ZC,R1J,R2L,R3M),(ZC,R1J,R2L,R3N),
(ZC,R1J,R2L,R3O),(ZC,R1J,R2L,R3P),(ZC,R1J,R2L,R3Q),
(ZC,R1J,R2L,R3R),(ZC,R1J,R2M,R3A),(ZC,R1J,R2M,R3B),
(ZC,R1J,R2M,R3C),(ZC,R1J,R2M,R3D),(ZC,R1J,R2M,R3E),
(ZC,R1J,R2M,R3F),(ZC,R1J,R2M,R3G),(ZC,R1J,R2M,R3H),
(ZC,R1J,R2M,R3I),(ZC,R1J,R2M,R3J),(ZC,R1J,R2M,R3K),
(ZC,R1J,R2M,R3L),(ZC,R1J,R2M,R3M),(ZC,R1J,R2M,R3N),
(ZC,R1J,R2M,R3O),(ZC,R1J,R2M,R3P),(ZC,R1J,R2M,R3Q),
(ZC,R1J,R2M,R3R),(ZC,R1J,R2N,R3A),(ZC,R1J,R2N,R3B),
(ZC,R1J,R2N,R3C),(ZC,R1J,R2N,R3D),(ZC,R1J,R2N,R3E),
(ZC,R1J,R2N,R3F),(ZC,R1J,R2N,R3G),(ZC,R1J,R2N,R3H),
(ZC,R1J,R2N,R3I),(ZC,R1J,R2N,R3J),(ZC,R1J,R2N,R3K),
(ZC,R1J,R2N,R3L),(ZC,R1J,R2N,R3M),(ZC,R1J,R2N,R3N),
(ZC,R1J,R2N,R3O),(ZC,R1J,R2N,R3P),(ZC,R1J,R2N,R3Q),
(ZC,R1J,R2N,R3R),(ZC,R1K,R2A,R3A),(ZC,R1K,R2A,R3B),
(ZC,R1K,R2A,R3C),(ZC,R1K,R2A,R3D),(ZC,R1K,R2A,R3E),
(ZC,R1K,R2A,R3F),(ZC,R1K,R2A,R3G),(ZC,R1K,R2A,R3H),
(ZC,R1K,R2A,R3I),(ZC,R1K,R2A,R3J),(ZC,R1K,R2A,R3K),
(ZC,R1K,R2A,R3L),(ZC,R1K,R2A,R3M),(ZC,R1K,R2A,R3N),
(ZC,R1K,R2A,R3O),(ZC,R1K,R2A,R3P),(ZC,R1K,R2A,R3Q),
(ZC,R1K,R2A,R3R),(ZC,R1K,R2B,R3A),(ZC,R1K,R2B,R3B),
(ZC,R1K,R2B,R3C),(ZC,R1K,R2B,R3D),(ZC,R1K,R2B,R3E),
(ZC,R1K,R2B,R3F),(ZC,R1K,R2B,R3G),(ZC,R1K,R2B,R3H),
(ZC,R1K,R2B,R3I),(ZC,R1K,R2B,R3J),(ZC,R1K,R2B,R3K),
(ZC,R1K,R2B,R3L),(ZC,R1K,R2B,R3M),(ZC,R1K,R2B,R3N),
(ZC,R1K,R2B,R3O),(ZC,R1K,R2B,R3P),(ZC,R1K,R2B,R3Q),
(ZC,R1K,R2B,R3R),(ZC,R1K,R2C,R3A),(ZC,R1K,R2C,R3B),
(ZC,R1K,R2C,R3C),(ZC,R1K,R2C,R3D),(ZC,R1K,R2C,R3E),
(ZC,R1K,R2C,R3F),(ZC,R1K,R2C,R3G),(ZC,R1K,R2C,R3H),
(ZC,R1K,R2C,R3I),(ZC,R1K,R2C,R3J),(ZC,R1K,R2C,R3K),
(ZC,R1K,R2C,R3L),(ZC,R1K,R2C,R3M),(ZC,R1K,R2C,R3N),
(ZC,R1K,R2C,R3O),(ZC,R1K,R2C,R3P),(ZC,R1K,R2C,R3Q),
(ZC,R1K,R2C,R3R),(ZC,R1K,R2D,R3A),(ZC,R1K,R2D,R3B),
(ZC,R1K,R2D,R3C),(ZC,R1K,R2D,R3D),(ZC,R1K,R2D,R3E),
(ZC,R1K,R2D,R3F),(ZC,R1K,R2D,R3G),(ZC,R1K,R2D,R3H),
(ZC,R1K,R2D,R3I),(ZC,R1K,R2D,R3J),(ZC,R1K,R2D,R3K),
(ZC,R1K,R2D,R3L),(ZC,R1K,R2D,R3M),(ZC,R1K,R2D,R3N),
(ZC,R1K,R2D,R3O),(ZC,R1K,R2D,R3P),(ZC,R1K,R2D,R3Q),
(ZC,R1K,R2D,R3R),(ZC,R1K,R2E,R3A),(ZC,R1K,R2E,R3B),
(ZC,R1K,R2E,R3C),(ZC,R1K,R2E,R3D),(ZC,R1K,R2E,R3E),
(ZC,R1K,R2E,R3F),(ZC,R1K,R2E,R3G),(ZC,R1K,R2E,R3H),
(ZC,R1K,R2E,R3I),(ZC,R1K,R2E,R3J),(ZC,R1K,R2E,R3K),
(ZC,R1K,R2E,R3L),(ZC,R1K,R2E,R3M),(ZC,R1K,R2E,R3N),
(ZC,R1K,R2E,R3O),(ZC,R1K,R2E,R3P),(ZC,R1K,R2E,R3Q),
(ZC,R1K,R2E,R3R),(ZC,R1K,R2F,R3A),(ZC,R1K,R2F,R3B),
(ZC,R1K,R2F,R3C),(ZC,R1K,R2F,R3D),(ZC,R1K,R2F,R3E),
(ZC,R1K,R2F,R3F),(ZC,R1K,R2F,R3G),(ZC,R1K,R2F,R3H),
(ZC,R1K,R2F,R3I),(ZC,R1K,R2F,R3J),(ZC,R1K,R2F,R3K),
(ZC,R1K,R2F,R3L),(ZC,R1K,R2F,R3M),(ZC,R1K,R2F,R3N),
(ZC,R1K,R2F,R3O),(ZC,R1K,R2F,R3P),(ZC,R1K,R2F,R3Q),
(ZC,R1K,R2F,R3R),(ZC,R1K,R2G,R3A),(ZC,R1K,R2G,R3B),
(ZC,R1K,R2G,R3C),(ZC,R1K,R2G,R3D),(ZC,R1K,R2G,R3E),
(ZC,R1K,R2G,R3F),(ZC,R1K,R2G,R3G),(ZC,R1K,R2G,R3H),
(ZC,R1K,R2G,R3I),(ZC,R1K,R2G,R3J),(ZC,R1K,R2G,R3K),
(ZC,R1K,R2G,R3L),(ZC,R1K,R2G,R3M),(ZC,R1K,R2G,R3N),
(ZC,R1K,R2G,R3O),(ZC,R1K,R2G,R3P),(ZC,R1K,R2G,R3Q),
(ZC,R1K,R2G,R3R),(ZC,R1K,R2H,R3A),(ZC,R1K,R2H,R3B),
(ZC,R1K,R2H,R3C),(ZC,R1K,R2H,R3D),(ZC,R1K,R2H,R3E),
(ZC,R1K,R2H,R3F),(ZC,R1K,R2H,R3G),(ZC,R1K,R2H,R3H),
(ZC,R1K,R2H,R3I),(ZC,R1K,R2H,R3J),(ZC,R1K,R2H,R3K),
(ZC,R1K,R2H,R3L),(ZC,R1K,R2H,R3M),(ZC,R1K,R2H,R3N),
(ZC,R1K,R2H,R3O),(ZC,R1K,R2H,R3P),(ZC,R1K,R2H,R3Q),
(ZC,R1K,R2H,R3R),(ZC,R1K,R2I,R3A),(ZC,R1K,R2I,R3B),
(ZC,R1K,R2I,R3C),(ZC,R1K,R2I,R3D),(ZC,R1K,R2I,R3E),
(ZC,R1K,R2I,R3F),(ZC,R1K,R2I,R3G),(ZC,R1K,R2I,R3H),
(ZC,R1K,R2I,R3I),(ZC,R1K,R2I,R3J),(ZC,R1K,R2I,R3K),
(ZC,R1K,R2I,R3L),(ZC,R1K,R2I,R3M),(ZC,R1K,R2I,R3N),
(ZC,R1K,R2I,R3O),(ZC,R1K,R2I,R3P),(ZC,R1K,R2I,R3Q),
(ZC,R1K,R2I,R3R),(ZC,R1K,R2J,R3A),(ZC,R1K,R2J,R3B),
(ZC,R1K,R2J,R3C),(ZC,R1K,R2J,R3D),(ZC,R1K,R2J,R3E),
(ZC,R1K,R2J,R3F),(ZC,R1K,R2J,R3G),(ZC,R1K,R2J,R3H),
(ZC,R1K,R2J,R3I),(ZC,R1K,R2J,R3J),(ZC,R1K,R2J,R3K),
(ZC,R1K,R2J,R3L),(ZC,R1K,R2J,R3M),(ZC,R1K,R2J,R3N),
(ZC,R1K,R2J,R3O),(ZC,R1K,R2J,R3P),(ZC,R1K,R2J,R3Q),
(ZC,R1K,R2J,R3R),(ZC,R1K,R2K,R3A),(ZC,R1K,R2K,R3B),
(ZC,R1K,R2K,R3C),(ZC,R1K,R2K,R3D),(ZC,R1K,R2K,R3E),
(ZC,R1K,R2K,R3F),(ZC,R1K,R2K,R3G),(ZC,R1K,R2K,R3H),
(ZC,R1K,R2K,R3I),(ZC,R1K,R2K,R3J),(ZC,R1K,R2K,R3K),
(ZC,R1K,R2K,R3L),(ZC,R1K,R2K,R3M),(ZC,R1K,R2K,R3N),
(ZC,R1K,R2K,R3O),(ZC,R1K,R2K,R3P),(ZC,R1K,R2K,R3Q),
(ZC,R1K,R2K,R3R),(ZC,R1K,R2L,R3A),(ZC,R1K,R2L,R3B),
(ZC,R1K,R2L,R3C),(ZC,R1K,R2L,R3D),(ZC,R1K,R2L,R3E),
(ZC,R1K,R2L,R3F),(ZC,R1K,R2L,R3G),(ZC,R1K,R2L,R3H),
(ZC,R1K,R2L,R3I),(ZC,R1K,R2L,R3J),(ZC,R1K,R2L,R3K),
(ZC,R1K,R2L,R3L),(ZC,R1K,R2L,R3M),(ZC,R1K,R2L,R3N),
(ZC,R1K,R2L,R3O),(ZC,R1K,R2L,R3P),(ZC,R1K,R2L,R3Q),
(ZC,R1K,R2L,R3R),(ZC,R1K,R2M,R3A),(ZC,R1K,R2M,R3B),
(ZC,R1K,R2M,R3C),(ZC,R1K,R2M,R3D),(ZC,R1K,R2M,R3E),
(ZC,R1K,R2M,R3F),(ZC,R1K,R2M,R3G),(ZC,R1K,R2M,R3H),
(ZC,R1K,R2M,R3I),(ZC,R1K,R2M,R3J),(ZC,R1K,R2M,R3K),
(ZC,R1K,R2M,R3L),(ZC,R1K,R2M,R3M),(ZC,R1K,R2M,R3N),
(ZC,R1K,R2M,R3O),(ZC,R1K,R2M,R3P),(ZC,R1K,R2M,R3Q),
(ZC,R1K,R2M,R3R),(ZC,R1K,R2N,R3A),(ZC,R1K,R2N,R3B),
(ZC,R1K,R2N,R3C),(ZC,R1K,R2N,R3D),(ZC,R1K,R2N,R3E),
(ZC,R1K,R2N,R3F),(ZC,R1K,R2N,R3G),(ZC,R1K,R2N,R3H),
(ZC,R1K,R2N,R3I),(ZC,R1K,R2N,R3J),(ZC,R1K,R2N,R3K),
(ZC,R1K,R2N,R3L),(ZC,R1K,R2N,R3M),(ZC,R1K,R2N,R3N),
(ZC,R1K,R2N,R3O),(ZC,R1K,R2N,R3P),(ZC,R1K,R2N,R3Q),
(ZC,R1K,R2N,R3R),(ZC,R1L,R2A,R3A),(ZC,R1L,R2A,R3B),
(ZC,R1L,R2A,R3C),(ZC,R1L,R2A,R3D),(ZC,R1L,R2A,R3E),
(ZC,R1L,R2A,R3F),(ZC,R1L,R2A,R3G),(ZC,R1L,R2A,R3H),
(ZC,R1L,R2A,R3I),(ZC,R1L,R2A,R3J),(ZC,R1L,R2A,R3K),
(ZC,R1L,R2A,R3L),(ZC,R1L,R2A,R3M),(ZC,R1L,R2A,R3N),
(ZC,R1L,R2A,R3O),(ZC,R1L,R2A,R3P),(ZC,R1L,R2A,R3Q),
(ZC,R1L,R2A,R3R),(ZC,R1L,R2B,R3A),(ZC,R1L,R2B,R3B),
(ZC,R1L,R2B,R3C),(ZC,R1L,R2B,R3D),(ZC,R1L,R2B,R3E),
(ZC,R1L,R2B,R3F),(ZC,R1L,R2B,R3G),(ZC,R1L,R2B,R3H),
(ZC,R1L,R2B,R3I),(ZC,R1L,R2B,R3J),(ZC,R1L,R2B,R3K),
(ZC,R1L,R2B,R3L),(ZC,R1L,R2B,R3M),(ZC,R1L,R2B,R3N),
(ZC,R1L,R2B,R3O),(ZC,R1L,R2B,R3P),(ZC,R1L,R2B,R3Q),
(ZC,R1L,R2B,R3R),(ZC,R1L,R2C,R3A),(ZC,R1L,R2C,R3B),
(ZC,R1L,R2C,R3C),(ZC,R1L,R2C,R3D),(ZC,R1L,R2C,R3E),
(ZC,R1L,R2C,R3F),(ZC,R1L,R2C,R3G),(ZC,R1L,R2C,R3H),
(ZC,R1L,R2C,R3I),(ZC,R1L,R2C,R3J),(ZC,R1L,R2C,R3K),
(ZC,R1L,R2C,R3L),(ZC,R1L,R2C,R3M),(ZC,R1L,R2C,R3N),
(ZC,R1L,R2C,R3O),(ZC,R1L,R2C,R3P),(ZC,R1L,R2C,R3Q),
(ZC,R1L,R2C,R3R),(ZC,R1L,R2D,R3A),(ZC,R1L,R2D,R3B),
(ZC,R1L,R2D,R3C),(ZC,R1L,R2D,R3D),(ZC,R1L,R2D,R3E),
(ZC,R1L,R2D,R3F),(ZC,R1L,R2D,R3G),(ZC,R1L,R2D,R3H),
(ZC,R1L,R2D,R3I),(ZC,R1L,R2D,R3J),(ZC,R1L,R2D,R3K),
(ZC,R1L,R2D,R3L),(ZC,R1L,R2D,R3M),(ZC,R1L,R2D,R3N),
(ZC,R1L,R2D,R3O),(ZC,R1L,R2D,R3P),(ZC,R1L,R2D,R3Q),
(ZC,R1L,R2D,R3R),(ZC,R1L,R2E,R3A),(ZC,R1L,R2E,R3B),
(ZC,R1L,R2E,R3C),(ZC,R1L,R2E,R3D),(ZC,R1L,R2E,R3E),
(ZC,R1L,R2E,R3F),(ZC,R1L,R2E,R3G),(ZC,R1L,R2E,R3H),
(ZC,R1L,R2E,R3I),(ZC,R1L,R2E,R3J),(ZC,R1L,R2E,R3K),
(ZC,R1L,R2E,R3L),(ZC,R1L,R2E,R3M),(ZC,R1L,R2E,R3N),
(ZC,R1L,R2E,R3O),(ZC,R1L,R2E,R3P),(ZC,R1L,R2E,R3Q),
(ZC,R1L,R2E,R3R),(ZC,R1L,R2F,R3A),(ZC,R1L,R2F,R3B),
(ZC,R1L,R2F,R3C),(ZC,R1L,R2F,R3D),(ZC,R1L,R2F,R3E),
(ZC,R1L,R2F,R3F),(ZC,R1L,R2F,R3G),(ZC,R1L,R2F,R3H),
(ZC,R1L,R2F,R3I),(ZC,R1L,R2F,R3J),(ZC,R1L,R2F,R3K),
(ZC,R1L,R2F,R3L),(ZC,R1L,R2F,R3M),(ZC,R1L,R2F,R3N),
(ZC,R1L,R2F,R3O),(ZC,R1L,R2F,R3P),(ZC,R1L,R2F,R3Q),
(ZC,R1L,R2F,R3R),(ZC,R1L,R2G,R3A),(ZC,R1L,R2G,R3B),
(ZC,R1L,R2G,R3C),(ZC,R1L,R2G,R3D),(ZC,R1L,R2G,R3E),
(ZC,R1L,R2G,R3F),(ZC,R1L,R2G,R3G),(ZC,R1L,R2G,R3H),
(ZC,R1L,R2G,R3I),(ZC,R1L,R2G,R3J),(ZC,R1L,R2G,R3K),
(ZC,R1L,R2G,R3L),(ZC,R1L,R2G,R3M),(ZC,R1L,R2G,R3N),
(ZC,R1L,R2G,R3O),(ZC,R1L,R2G,R3P),(ZC,R1L,R2G,R3Q),
(ZC,R1L,R2G,R3R),(ZC,R1L,R2H,R3A),(ZC,R1L,R2H,R3B),
(ZC,R1L,R2H,R3C),(ZC,R1L,R2H,R3D),(ZC,R1L,R2H,R3E),
(ZC,R1L,R2H,R3F),(ZC,R1L,R2H,R3G),(ZC,R1L,R2H,R3H),
(ZC,R1L,R2H,R3I),(ZC,R1L,R2H,R3J),(ZC,R1L,R2H,R3K),
(ZC,R1L,R2H,R3L),(ZC,R1L,R2H,R3M),(ZC,R1L,R2H,R3N),
(ZC,R1L,R2H,R3O),(ZC,R1L,R2H,R3P),(ZC,R1L,R2H,R3Q),
(ZC,R1L,R2H,R3R),(ZC,R1L,R2I,R3A),(ZC,R1L,R2I,R3B),
(ZC,R1L,R2I,R3C),(ZC,R1L,R2I,R3D),(ZC,R1L,R2I,R3E),
(ZC,R1L,R2I,R3F),(ZC,R1L,R2I,R3G),(ZC,R1L,R2I,R3H),
(ZC,R1L,R2I,R3I),(ZC,R1L,R2I,R3J),(ZC,R1L,R2I,R3K),
(ZC,R1L,R2I,R3L),(ZC,R1L,R2I,R3M),(ZC,R1L,R2I,R3N),
(ZC,R1L,R2I,R3O),(ZC,R1L,R2I,R3P),(ZC,R1L,R2I,R3Q),
(ZC,R1L,R2I,R3R),(ZC,R1L,R2J,R3A),(ZC,R1L,R2J,R3B),
(ZC,R1L,R2J,R3C),(ZC,R1L,R2J,R3D),(ZC,R1L,R2J,R3E),
(ZC,R1L,R2J,R3F),(ZC,R1L,R2J,R3G),(ZC,R1L,R2J,R3H),
(ZC,R1L,R2J,R3I),(ZC,R1L,R2J,R3J),(ZC,R1L,R2J,R3K),
(ZC,R1L,R2J,R3L),(ZC,R1L,R2J,R3M),(ZC,R1L,R2J,R3N),
(ZC,R1L,R2J,R3O),(ZC,R1L,R2J,R3P),(ZC,R1L,R2J,R3Q),
(ZC,R1L,R2J,R3R),(ZC,R1L,R2K,R3A),(ZC,R1L,R2K,R3B),
(ZC,R1L,R2K,R3C),(ZC,R1L,R2K,R3D),(ZC,R1L,R2K,R3E),
(ZC,R1L,R2K,R3F),(ZC,R1L,R2K,R3G),(ZC,R1L,R2K,R3H),
(ZC,R1L,R2K,R3I),(ZC,R1L,R2K,R3J),(ZC,R1L,R2K,R3K),
(ZC,R1L,R2K,R3L),(ZC,R1L,R2K,R3M),(ZC,R1L,R2K,R3N),
(ZC,R1L,R2K,R3O),(ZC,R1L,R2K,R3P),(ZC,R1L,R2K,R3Q),
(ZC,R1L,R2K,R3R),(ZC,R1L,R2L,R3A),(ZC,R1L,R2L,R3B),
(ZC,R1L,R2L,R3C),(ZC,R1L,R2L,R3D),(ZC,R1L,R2L,R3E),
(ZC,R1L,R2L,R3F),(ZC,R1L,R2L,R3G),(ZC,R1L,R2L,R3H),
(ZC,R1L,R2L,R3I),(ZC,R1L,R2L,R3J),(ZC,R1L,R2L,R3K),
(ZC,R1L,R2L,R3L),(ZC,R1L,R2L,R3M),(ZC,R1L,R2L,R3N),
(ZC,R1L,R2L,R3O),(ZC,R1L,R2L,R3P),(ZC,R1L,R2L,R3Q),
(ZC,R1L,R2L,R3R),(ZC,R1L,R2M,R3A),(ZC,R1L,R2M,R3B),
(ZC,R1L,R2M,R3C),(ZC,R1L,R2M,R3D),(ZC,R1L,R2M,R3E),
(ZC,R1L,R2M,R3F),(ZC,R1L,R2M,R3G),(ZC,R1L,R2M,R3H),
(ZC,R1L,R2M,R3I),(ZC,R1L,R2M,R3J),(ZC,R1L,R2M,R3K),
(ZC,R1L,R2M,R3L),(ZC,R1L,R2M,R3M),(ZC,R1L,R2M,R3N),
(ZC,R1L,R2M,R3O),(ZC,R1L,R2M,R3P),(ZC,R1L,R2M,R3Q),
(ZC,R1L,R2M,R3R),(ZC,R1L,R2N,R3A),(ZC,R1L,R2N,R3B),
(ZC,R1L,R2N,R3C),(ZC,R1L,R2N,R3D),(ZC,R1L,R2N,R3E),
(ZC,R1L,R2N,R3F),(ZC,R1L,R2N,R3G),(ZC,R1L,R2N,R3H),
(ZC,R1L,R2N,R3I),(ZC,R1L,R2N,R3J),(ZC,R1L,R2N,R3K),
(ZC,R1L,R2N,R3L),(ZC,R1L,R2N,R3M),(ZC,R1L,R2N,R3N),
(ZC,R1L,R2N,R3O),(ZC,R1L,R2N,R3P),(ZC,R1L,R2N,R3Q),
(ZC,R1L,R2N,R3R),(ZC,R1M,R2A,R3A),(ZC,R1M,R2A,R3B),
(ZC,R1M,R2A,R3C),(ZC,R1M,R2A,R3D),(ZC,R1M,R2A,R3E),
(ZC,R1M,R2A,R3F),(ZC,R1M,R2A,R3G),(ZC,R1M,R2A,R3H),
(ZC,R1M,R2A,R3I),(ZC,R1M,R2A,R3J),(ZC,R1M,R2A,R3K),
(ZC,R1M,R2A,R3L),(ZC,R1M,R2A,R3M),(ZC,R1M,R2A,R3N),
(ZC,R1M,R2A,R3O),(ZC,R1M,R2A,R3P),(ZC,R1M,R2A,R3Q),
(ZC,R1M,R2A,R3R),(ZC,R1M,R2B,R3A),(ZC,R1M,R2B,R3B),
(ZC,R1M,R2B,R3C),(ZC,R1M,R2B,R3D),(ZC,R1M,R2B,R3E),
(ZC,R1M,R2B,R3F),(ZC,R1M,R2B,R3G),(ZC,R1M,R2B,R3H),
(ZC,R1M,R2B,R3I),(ZC,R1M,R2B,R3J),(ZC,R1M,R2B,R3K),
(ZC,R1M,R2B,R3L),(ZC,R1M,R2B,R3M),(ZC,R1M,R2B,R3N),
(ZC,R1M,R2B,R3O),(ZC,R1M,R2B,R3P),(ZC,R1M,R2B,R3Q),
(ZC,R1M,R2B,R3R),(ZC,R1M,R2C,R3A),(ZC,R1M,R2C,R3B),
(ZC,R1M,R2C,R3C),(ZC,R1M,R2C,R3D),(ZC,R1M,R2C,R3E),
(ZC,R1M,R2C,R3F),(ZC,R1M,R2C,R3G),(ZC,R1M,R2C,R3H),
(ZC,R1M,R2C,R3I),(ZC,R1M,R2C,R3J),(ZC,R1M,R2C,R3K),
(ZC,R1M,R2C,R3L),(ZC,R1M,R2C,R3M),(ZC,R1M,R2C,R3N),
(ZC,R1M,R2C,R3O),(ZC,R1M,R2C,R3P),(ZC,R1M,R2C,R3Q),
(ZC,R1M,R2C,R3R),(ZC,R1M,R2D,R3A),(ZC,R1M,R2D,R3B),
(ZC,R1M,R2D,R3C),(ZC,R1M,R2D,R3D),(ZC,R1M,R2D,R3E),
(ZC,R1M,R2D,R3F),(ZC,R1M,R2D,R3G),(ZC,R1M,R2D,R3H),
(ZC,R1M,R2D,R3I),(ZC,R1M,R2D,R3J),(ZC,R1M,R2D,R3K),
(ZC,R1M,R2D,R3L),(ZC,R1M,R2D,R3M),(ZC,R1M,R2D,R3N),
(ZC,R1M,R2D,R3O),(ZC,R1M,R2D,R3P),(ZC,R1M,R2D,R3Q),
(ZC,R1M,R2D,R3R),(ZC,R1M,R2E,R3A),(ZC,R1M,R2E,R3B),
(ZC,R1M,R2E,R3C),(ZC,R1M,R2E,R3D),(ZC,R1M,R2E,R3E),
(ZC,R1M,R2E,R3F),(ZC,R1M,R2E,R3G),(ZC,R1M,R2E,R3H),
(ZC,R1M,R2E,R3I),(ZC,R1M,R2E,R3J),(ZC,R1M,R2E,R3K),
(ZC,R1M,R2E,R3L),(ZC,R1M,R2E,R3M),(ZC,R1M,R2E,R3N),
(ZC,R1M,R2E,R3O),(ZC,R1M,R2E,R3P),(ZC,R1M,R2E,R3Q),
(ZC,R1M,R2E,R3R),(ZC,R1M,R2F,R3A),(ZC,R1M,R2F,R3B),
(ZC,R1M,R2F,R3C),(ZC,R1M,R2F,R3D),(ZC,R1M,R2F,R3E),
(ZC,R1M,R2F,R3F),(ZC,R1M,R2F,R3G),(ZC,R1M,R2F,R3H),
(ZC,R1M,R2F,R3I),(ZC,R1M,R2F,R3J),(ZC,R1M,R2F,R3K),
(ZC,R1M,R2F,R3L),(ZC,R1M,R2F,R3M),(ZC,R1M,R2F,R3N),
(ZC,R1M,R2F,R3O),(ZC,R1M,R2F,R3P),(ZC,R1M,R2F,R3Q),
(ZC,R1M,R2F,R3R),(ZC,R1M,R2G,R3A),(ZC,R1M,R2G,R3B),
(ZC,R1M,R2G,R3C),(ZC,R1M,R2G,R3D),(ZC,R1M,R2G,R3E),
(ZC,R1M,R2G,R3F),(ZC,R1M,R2G,R3G),(ZC,R1M,R2G,R3H),
(ZC,R1M,R2G,R3I),(ZC,R1M,R2G,R3J),(ZC,R1M,R2G,R3K),
(ZC,R1M,R2G,R3L),(ZC,R1M,R2G,R3M),(ZC,R1M,R2G,R3N),
(ZC,R1M,R2G,R3O),(ZC,R1M,R2G,R3P),(ZC,R1M,R2G,R3Q),
(ZC,R1M,R2G,R3R),(ZC,R1M,R2H,R3A),(ZC,R1M,R2H,R3B),
(ZC,R1M,R2H,R3C),(ZC,R1M,R2H,R3D),(ZC,R1M,R2H,R3E),
(ZC,R1M,R2H,R3F),(ZC,R1M,R2H,R3G),(ZC,R1M,R2H,R3H),
(ZC,R1M,R2H,R3I),(ZC,R1M,R2H,R3J),(ZC,R1M,R2H,R3K),
(ZC,R1M,R2H,R3L),(ZC,R1M,R2H,R3M),(ZC,R1M,R2H,R3N),
(ZC,R1M,R2H,R3O),(ZC,R1M,R2H,R3P),(ZC,R1M,R2H,R3Q),
(ZC,R1M,R2H,R3R),(ZC,R1M,R2I,R3A),(ZC,R1M,R2I,R3B),
(ZC,R1M,R2I,R3C),(ZC,R1M,R2I,R3D),(ZC,R1M,R2I,R3E),
(ZC,R1M,R2I,R3F),(ZC,R1M,R2I,R3G),(ZC,R1M,R2I,R3H),
(ZC,R1M,R2I,R3I),(ZC,R1M,R2I,R3J),(ZC,R1M,R2I,R3K),
(ZC,R1M,R2I,R3L),(ZC,R1M,R2I,R3M),(ZC,R1M,R2I,R3N),
(ZC,R1M,R2I,R3O),(ZC,R1M,R2I,R3P),(ZC,R1M,R2I,R3Q),
(ZC,R1M,R2I,R3R),(ZC,R1M,R2J,R3A),(ZC,R1M,R2J,R3B),
(ZC,R1M,R2J,R3C),(ZC,R1M,R2J,R3D),(ZC,R1M,R2J,R3E),
(ZC,R1M,R2J,R3F),(ZC,R1M,R2J,R3G),(ZC,R1M,R2J,R3H),
(ZC,R1M,R2J,R3I),(ZC,R1M,R2J,R3J),(ZC,R1M,R2J,R3K),
(ZC,R1M,R2J,R3L),(ZC,R1M,R2J,R3M),(ZC,R1M,R2J,R3N),
(ZC,R1M,R2J,R3O),(ZC,R1M,R2J,R3P),(ZC,R1M,R2J,R3Q),
(ZC,R1M,R2J,R3R),(ZC,R1M,R2K,R3A),(ZC,R1M,R2K,R3B),
(ZC,R1M,R2K,R3C),(ZC,R1M,R2K,R3D),(ZC,R1M,R2K,R3E),
(ZC,R1M,R2K,R3F),(ZC,R1M,R2K,R3G),(ZC,R1M,R2K,R3H),
(ZC,R1M,R2K,R3I),(ZC,R1M,R2K,R3J),(ZC,R1M,R2K,R3K),
(ZC,R1M,R2K,R3L),(ZC,R1M,R2K,R3M),(ZC,R1M,R2K,R3N),
(ZC,R1M,R2K,R3O),(ZC,R1M,R2K,R3P),(ZC,R1M,R2K,R3Q),
(ZC,R1M,R2K,R3R),(ZC,R1M,R2L,R3A),(ZC,R1M,R2L,R3B),
(ZC,R1M,R2L,R3C),(ZC,R1M,R2L,R3D),(ZC,R1M,R2L,R3E),
(ZC,R1M,R2L,R3F),(ZC,R1M,R2L,R3G),(ZC,R1M,R2L,R3H),
(ZC,R1M,R2L,R3I),(ZC,R1M,R2L,R3J),(ZC,R1M,R2L,R3K),
(ZC,R1M,R2L,R3L),(ZC,R1M,R2L,R3M),(ZC,R1M,R2L,R3N),
(ZC,R1M,R2L,R3O),(ZC,R1M,R2L,R3P),(ZC,R1M,R2L,R3Q),
(ZC,R1M,R2L,R3R),(ZC,R1M,R2M,R3A),(ZC,R1M,R2M,R3B),
(ZC,R1M,R2M,R3C),(ZC,R1M,R2M,R3D),(ZC,R1M,R2M,R3E),
(ZC,R1M,R2M,R3F),(ZC,R1M,R2M,R3G),(ZC,R1M,R2M,R3H),
(ZC,R1M,R2M,R3I),(ZC,R1M,R2M,R3J),(ZC,R1M,R2M,R3K),
(ZC,R1M,R2M,R3L),(ZC,R1M,R2M,R3M),(ZC,R1M,R2M,R3N),
(ZC,R1M,R2M,R3O),(ZC,R1M,R2M,R3P),(ZC,R1M,R2M,R3Q),
(ZC,R1M,R2M,R3R),(ZC,R1M,R2N,R3A),(ZC,R1M,R2N,R3B),
(ZC,R1M,R2N,R3C),(ZC,R1M,R2N,R3D),(ZC,R1M,R2N,R3E),
(ZC,R1M,R2N,R3F),(ZC,R1M,R2N,R3G),(ZC,R1M,R2N,R3H),
(ZC,R1M,R2N,R3I),(ZC,R1M,R2N,R3J),(ZC,R1M,R2N,R3K),
(ZC,R1M,R2N,R3L),(ZC,R1M,R2N,R3M),(ZC,R1M,R2N,R3N),
(ZC,R1M,R2N,R3O),(ZC,R1M,R2N,R3P),(ZC,R1M,R2N,R3Q),
(ZC,R1M,R2N,R3R),(ZC,R1N,R2A,R3A),(ZC,R1N,R2A,R3B),
(ZC,R1N,R2A,R3C),(ZC,R1N,R2A,R3D),(ZC,R1N,R2A,R3E),
(ZC,R1N,R2A,R3F),(ZC,R1N,R2A,R3G),(ZC,R1N,R2A,R3H),
(ZC,R1N,R2A,R3I),(ZC,R1N,R2A,R3J),(ZC,R1N,R2A,R3K),
(ZC,R1N,R2A,R3L),(ZC,R1N,R2A,R3M),(ZC,R1N,R2A,R3N),
(ZC,R1N,R2A,R3O),(ZC,R1N,R2A,R3P),(ZC,R1N,R2A,R3Q),
(ZC,R1N,R2A,R3R),(ZC,R1N,R2B,R3A),(ZC,R1N,R2B,R3B),
(ZC,R1N,R2B,R3C),(ZC,R1N,R2B,R3D),(ZC,R1N,R2B,R3E),
(ZC,R1N,R2B,R3F),(ZC,R1N,R2B,R3G),(ZC,R1N,R2B,R3H),
(ZC,R1N,R2B,R3I),(ZC,R1N,R2B,R3J),(ZC,R1N,R2B,R3K),
(ZC,R1N,R2B,R3L),(ZC,R1N,R2B,R3M),(ZC,R1N,R2B,R3N),
(ZC,R1N,R2B,R3O),(ZC,R1N,R2B,R3P),(ZC,R1N,R2B,R3Q),
(ZC,R1N,R2B,R3R),(ZC,R1N,R2C,R3A),(ZC,R1N,R2C,R3B),
(ZC,R1N,R2C,R3C),(ZC,R1N,R2C,R3D),(ZC,R1N,R2C,R3E),
(ZC,R1N,R2C,R3F),(ZC,R1N,R2C,R3G),(ZC,R1N,R2C,R3H),
(ZC,R1N,R2C,R3I),(ZC,R1N,R2C,R3J),(ZC,R1N,R2C,R3K),
(ZC,R1N,R2C,R3L),(ZC,R1N,R2C,R3M),(ZC,R1N,R2C,R3N),
(ZC,R1N,R2C,R3O),(ZC,R1N,R2C,R3P),(ZC,R1N,R2C,R3Q),
(ZC,R1N,R2C,R3R),(ZC,R1N,R2D,R3A),(ZC,R1N,R2D,R3B),
(ZC,R1N,R2D,R3C),(ZC,R1N,R2D,R3D),(ZC,R1N,R2D,R3E),
(ZC,R1N,R2D,R3F),(ZC,R1N,R2D,R3G),(ZC,R1N,R2D,R3H),
(ZC,R1N,R2D,R3I),(ZC,R1N,R2D,R3J),(ZC,R1N,R2D,R3K),
(ZC,R1N,R2D,R3L),(ZC,R1N,R2D,R3M),(ZC,R1N,R2D,R3N),
(ZC,R1N,R2D,R3O),(ZC,R1N,R2D,R3P),(ZC,R1N,R2D,R3Q),
(ZC,R1N,R2D,R3R),(ZC,R1N,R2E,R3A),(ZC,R1N,R2E,R3B),
(ZC,R1N,R2E,R3C),(ZC,R1N,R2E,R3D),(ZC,R1N,R2E,R3E),
(ZC,R1N,R2E,R3F),(ZC,R1N,R2E,R3G),(ZC,R1N,R2E,R3H),
(ZC,R1N,R2E,R3I),(ZC,R1N,R2E,R3J),(ZC,R1N,R2E,R3K),
(ZC,R1N,R2E,R3L),(ZC,R1N,R2E,R3M),(ZC,R1N,R2E,R3N),
(ZC,R1N,R2E,R3O),(ZC,R1N,R2E,R3P),(ZC,R1N,R2E,R3Q),
(ZC,R1N,R2E,R3R),(ZC,R1N,R2F,R3A),(ZC,R1N,R2F,R3B),
(ZC,R1N,R2F,R3C),(ZC,R1N,R2F,R3D),(ZC,R1N,R2F,R3E),
(ZC,R1N,R2F,R3F),(ZC,R1N,R2F,R3G),(ZC,R1N,R2F,R3H),
(ZC,R1N,R2F,R3I),(ZC,R1N,R2F,R3J),(ZC,R1N,R2F,R3K),
(ZC,R1N,R2F,R3L),(ZC,R1N,R2F,R3M),(ZC,R1N,R2F,R3N),
(ZC,R1N,R2F,R3O),(ZC,R1N,R2F,R3P),(ZC,R1N,R2F,R3Q),
(ZC,R1N,R2F,R3R),(ZC,R1N,R2G,R3A),(ZC,R1N,R2G,R3B),
(ZC,R1N,R2G,R3C),(ZC,R1N,R2G,R3D),(ZC,R1N,R2G,R3E),
(ZC,R1N,R2G,R3F),(ZC,R1N,R2G,R3G),(ZC,R1N,R2G,R3H),
(ZC,R1N,R2G,R3I),(ZC,R1N,R2G,R3J),(ZC,R1N,R2G,R3K),
(ZC,R1N,R2G,R3L),(ZC,R1N,R2G,R3M),(ZC,R1N,R2G,R3N),
(ZC,R1N,R2G,R3O),(ZC,R1N,R2G,R3P),(ZC,R1N,R2G,R3Q),
(ZC,R1N,R2G,R3R),(ZC,R1N,R2H,R3A),(ZC,R1N,R2H,R3B),
(ZC,R1N,R2H,R3C),(ZC,R1N,R2H,R3D),(ZC,R1N,R2H,R3E),
(ZC,R1N,R2H,R3F),(ZC,R1N,R2H,R3G),(ZC,R1N,R2H,R3H),
(ZC,R1N,R2H,R3I),(ZC,R1N,R2H,R3J),(ZC,R1N,R2H,R3K),
(ZC,R1N,R2H,R3L),(ZC,R1N,R2H,R3M),(ZC,R1N,R2H,R3N),
(ZC,R1N,R2H,R3O),(ZC,R1N,R2H,R3P),(ZC,R1N,R2H,R3Q),
(ZC,R1N,R2H,R3R),(ZC,R1N,R2I,R3A),(ZC,R1N,R2I,R3B),
(ZC,R1N,R2I,R3C),(ZC,R1N,R2I,R3D),(ZC,R1N,R2I,R3E),
(ZC,R1N,R2I,R3F),(ZC,R1N,R2I,R3G),(ZC,R1N,R2I,R3H),
(ZC,R1N,R2I,R3I),(ZC,R1N,R2I,R3J),(ZC,R1N,R2I,R3K),
(ZC,R1N,R2I,R3L),(ZC,R1N,R2I,R3M),(ZC,R1N,R2I,R3N),
(ZC,R1N,R2I,R3O),(ZC,R1N,R2I,R3P),(ZC,R1N,R2I,R3Q),
(ZC,R1N,R2I,R3R),(ZC,R1N,R2J,R3A),(ZC,R1N,R2J,R3B),
(ZC,R1N,R2J,R3C),(ZC,R1N,R2J,R3D),(ZC,R1N,R2J,R3E),
(ZC,R1N,R2J,R3F),(ZC,R1N,R2J,R3G),(ZC,R1N,R2J,R3H),
(ZC,R1N,R2J,R3I),(ZC,R1N,R2J,R3J),(ZC,R1N,R2J,R3K),
(ZC,R1N,R2J,R3L),(ZC,R1N,R2J,R3M),(ZC,R1N,R2J,R3N),
(ZC,R1N,R2J,R3O),(ZC,R1N,R2J,R3P),(ZC,R1N,R2J,R3Q),
(ZC,R1N,R2J,R3R),(ZC,R1N,R2K,R3A),(ZC,R1N,R2K,R3B),
(ZC,R1N,R2K,R3C),(ZC,R1N,R2K,R3D),(ZC,R1N,R2K,R3E),
(ZC,R1N,R2K,R3F),(ZC,R1N,R2K,R3G),(ZC,R1N,R2K,R3H),
(ZC,R1N,R2K,R3I),(ZC,R1N,R2K,R3J),(ZC,R1N,R2K,R3K),
(ZC,R1N,R2K,R3L),(ZC,R1N,R2K,R3M),(ZC,R1N,R2K,R3N),
(ZC,R1N,R2K,R3O),(ZC,R1N,R2K,R3P),(ZC,R1N,R2K,R3Q),
(ZC,R1N,R2K,R3R),(ZC,R1N,R2L,R3A),(ZC,R1N,R2L,R3B),
(ZC,R1N,R2L,R3C),(ZC,R1N,R2L,R3D),(ZC,R1N,R2L,R3E),
(ZC,R1N,R2L,R3F),(ZC,R1N,R2L,R3G),(ZC,R1N,R2L,R3H),
(ZC,R1N,R2L,R3I),(ZC,R1N,R2L,R3J),(ZC,R1N,R2L,R3K),
(ZC,R1N,R2L,R3L),(ZC,R1N,R2L,R3M),(ZC,R1N,R2L,R3N),
(ZC,R1N,R2L,R3O),(ZC,R1N,R2L,R3P),(ZC,R1N,R2L,R3Q),
(ZC,R1N,R2L,R3R),(ZC,R1N,R2M,R3A),(ZC,R1N,R2M,R3B),
(ZC,R1N,R2M,R3C),(ZC,R1N,R2M,R3D),(ZC,R1N,R2M,R3E),
(ZC,R1N,R2M,R3F),(ZC,R1N,R2M,R3G),(ZC,R1N,R2M,R3H),
(ZC,R1N,R2M,R3I),(ZC,R1N,R2M,R3J),(ZC,R1N,R2M,R3K),
(ZC,R1N,R2M,R3L),(ZC,R1N,R2M,R3M),(ZC,R1N,R2M,R3N),
(ZC,R1N,R2M,R3O),(ZC,R1N,R2M,R3P),(ZC,R1N,R2M,R3Q),
(ZC,R1N,R2M,R3R),(ZC,R1N,R2N,R3A),(ZC,R1N,R2N,R3B),
(ZC,R1N,R2N,R3C),(ZC,R1N,R2N,R3D),(ZC,R1N,R2N,R3E),
(ZC,R1N,R2N,R3F),(ZC,R1N,R2N,R3G),(ZC,R1N,R2N,R3H),
(ZC,R1N,R2N,R3I),(ZC,R1N,R2N,R3J),(ZC,R1N,R2N,R3K),
(ZC,R1N,R2N,R3L),(ZC,R1N,R2N,R3M),(ZC,R1N,R2N,R3N),
(ZC,R1N,R2N,R3O),(ZC,R1N,R2N,R3P),(ZC,R1N,R2N,R3Q),
(ZC,R1N,R2N,R3R),(ZC,R1O,R2A,R3A),(ZC,R1O,R2A,R3B),
(ZC,R1O,R2A,R3C),(ZC,R1O,R2A,R3D),(ZC,R1O,R2A,R3E),
(ZC,R1O,R2A,R3F),(ZC,R1O,R2A,R3G),(ZC,R1O,R2A,R3H),
(ZC,R1O,R2A,R3I),(ZC,R1O,R2A,R3J),(ZC,R1O,R2A,R3K),
(ZC,R1O,R2A,R3L),(ZC,R1O,R2A,R3M),(ZC,R1O,R2A,R3N),
(ZC,R1O,R2A,R3O),(ZC,R1O,R2A,R3P),(ZC,R1O,R2A,R3Q),
(ZC,R1O,R2A,R3R),(ZC,R1O,R2B,R3A),(ZC,R1O,R2B,R3B),
(ZC,R1O,R2B,R3C),(ZC,R1O,R2B,R3D),(ZC,R1O,R2B,R3E),
(ZC,R1O,R2B,R3F),(ZC,R1O,R2B,R3G),(ZC,R1O,R2B,R3H),
(ZC,R1O,R2B,R3I),(ZC,R1O,R2B,R3J),(ZC,R1O,R2B,R3K),
(ZC,R1O,R2B,R3L),(ZC,R1O,R2B,R3M),(ZC,R1O,R2B,R3N),
(ZC,R1O,R2B,R3O),(ZC,R1O,R2B,R3P),(ZC,R1O,R2B,R3Q),
(ZC,R1O,R2B,R3R),(ZC,R1O,R2C,R3A),(ZC,R1O,R2C,R3B),
(ZC,R1O,R2C,R3C),(ZC,R1O,R2C,R3D),(ZC,R1O,R2C,R3E),
(ZC,R1O,R2C,R3F),(ZC,R1O,R2C,R3G),(ZC,R1O,R2C,R3H),
(ZC,R1O,R2C,R3I),(ZC,R1O,R2C,R3J),(ZC,R1O,R2C,R3K),
(ZC,R1O,R2C,R3L),(ZC,R1O,R2C,R3M),(ZC,R1O,R2C,R3N),
(ZC,R1O,R2C,R3O),(ZC,R1O,R2C,R3P),(ZC,R1O,R2C,R3Q),
(ZC,R1O,R2C,R3R),(ZC,R1O,R2D,R3A),(ZC,R1O,R2D,R3B),
(ZC,R1O,R2D,R3C),(ZC,R1O,R2D,R3D),(ZC,R1O,R2D,R3E),
(ZC,R1O,R2D,R3F),(ZC,R1O,R2D,R3G),(ZC,R1O,R2D,R3H),
(ZC,R1O,R2D,R3I),(ZC,R1O,R2D,R3J),(ZC,R1O,R2D,R3K),
(ZC,R1O,R2D,R3L),(ZC,R1O,R2D,R3M),(ZC,R1O,R2D,R3N),
(ZC,R1O,R2D,R3O),(ZC,R1O,R2D,R3P),(ZC,R1O,R2D,R3Q),
(ZC,R1O,R2D,R3R),(ZC,R1O,R2E,R3A),(ZC,R1O,R2E,R3B),
(ZC,R1O,R2E,R3C),(ZC,R1O,R2E,R3D),(ZC,R1O,R2E,R3E),
(ZC,R1O,R2E,R3F),(ZC,R1O,R2E,R3G),(ZC,R1O,R2E,R3H),
(ZC,R1O,R2E,R3I),(ZC,R1O,R2E,R3J),(ZC,R1O,R2E,R3K),
(ZC,R1O,R2E,R3L),(ZC,R1O,R2E,R3M),(ZC,R1O,R2E,R3N),
(ZC,R1O,R2E,R3O),(ZC,R1O,R2E,R3P),(ZC,R1O,R2E,R3Q),
(ZC,R1O,R2E,R3R),(ZC,R1O,R2F,R3A),(ZC,R1O,R2F,R3B),
(ZC,R1O,R2F,R3C),(ZC,R1O,R2F,R3D),(ZC,R1O,R2F,R3E),
(ZC,R1O,R2F,R3F),(ZC,R1O,R2F,R3G),(ZC,R1O,R2F,R3H),
(ZC,R1O,R2F,R3I),(ZC,R1O,R2F,R3J),(ZC,R1O,R2F,R3K),
(ZC,R1O,R2F,R3L),(ZC,R1O,R2F,R3M),(ZC,R1O,R2F,R3N),
(ZC,R1O,R2F,R3O),(ZC,R1O,R2F,R3P),(ZC,R1O,R2F,R3Q),
(ZC,R1O,R2F,R3R),(ZC,R1O,R2G,R3A),(ZC,R1O,R2G,R3B),
(ZC,R1O,R2G,R3C),(ZC,R1O,R2G,R3D),(ZC,R1O,R2G,R3E),
(ZC,R1O,R2G,R3F),(ZC,R1O,R2G,R3G),(ZC,R1O,R2G,R3H),
(ZC,R1O,R2G,R3I),(ZC,R1O,R2G,R3J),(ZC,R1O,R2G,R3K),
(ZC,R1O,R2G,R3L),(ZC,R1O,R2G,R3M),(ZC,R1O,R2G,R3N),
(ZC,R1O,R2G,R3O),(ZC,R1O,R2G,R3P),(ZC,R1O,R2G,R3Q),
(ZC,R1O,R2G,R3R),(ZC,R1O,R2H,R3A),(ZC,R1O,R2H,R3B),
(ZC,R1O,R2H,R3C),(ZC,R1O,R2H,R3D),(ZC,R1O,R2H,R3E),
(ZC,R1O,R2H,R3F),(ZC,R1O,R2H,R3G),(ZC,R1O,R2H,R3H),
(ZC,R1O,R2H,R3I),(ZC,R1O,R2H,R3J),(ZC,R1O,R2H,R3K),
(ZC,R1O,R2H,R3L),(ZC,R1O,R2H,R3M),(ZC,R1O,R2H,R3N),
(ZC,R1O,R2H,R3O),(ZC,R1O,R2H,R3P),(ZC,R1O,R2H,R3Q),
(ZC,R1O,R2H,R3R),(ZC,R1O,R2I,R3A),(ZC,R1O,R2I,R3B),
(ZC,R1O,R2I,R3C),(ZC,R1O,R2I,R3D),(ZC,R1O,R2I,R3E),
(ZC,R1O,R2I,R3F),(ZC,R1O,R2I,R3G),(ZC,R1O,R2I,R3H),
(ZC,R1O,R2I,R3I),(ZC,R1O,R2I,R3J),(ZC,R1O,R2I,R3K),
(ZC,R1O,R2I,R3L),(ZC,R1O,R2I,R3M),(ZC,R1O,R2I,R3N),
(ZC,R1O,R2I,R3O),(ZC,R1O,R2I,R3P),(ZC,R1O,R2I,R3Q),
(ZC,R1O,R2I,R3R),(ZC,R1O,R2J,R3A),(ZC,R1O,R2J,R3B),
(ZC,R1O,R2J,R3C),(ZC,R1O,R2J,R3D),(ZC,R1O,R2J,R3E),
(ZC,R1O,R2J,R3F),(ZC,R1O,R2J,R3G),(ZC,R1O,R2J,R3H),
(ZC,R1O,R2J,R3I),(ZC,R1O,R2J,R3J),(ZC,R1O,R2J,R3K),
(ZC,R1O,R2J,R3L),(ZC,R1O,R2J,R3M),(ZC,R1O,R2J,R3N),
(ZC,R1O,R2J,R3O),(ZC,R1O,R2J,R3P),(ZC,R1O,R2J,R3Q),
(ZC,R1O,R2J,R3R),(ZC,R1O,R2K,R3A),(ZC,R1O,R2K,R3B),
(ZC,R1O,R2K,R3C),(ZC,R1O,R2K,R3D),(ZC,R1O,R2K,R3E),
(ZC,R1O,R2K,R3F),(ZC,R1O,R2K,R3G),(ZC,R1O,R2K,R3H),
(ZC,R1O,R2K,R3I),(ZC,R1O,R2K,R3J),(ZC,R1O,R2K,R3K),
(ZC,R1O,R2K,R3L),(ZC,R1O,R2K,R3M),(ZC,R1O,R2K,R3N),
(ZC,R1O,R2K,R3O),(ZC,R1O,R2K,R3P),(ZC,R1O,R2K,R3Q),
(ZC,R1O,R2K,R3R),(ZC,R1O,R2L,R3A),(ZC,R1O,R2L,R3B),
(ZC,R1O,R2L,R3C),(ZC,R1O,R2L,R3D),(ZC,R1O,R2L,R3E),
(ZC,R1O,R2L,R3F),(ZC,R1O,R2L,R3G),(ZC,R1O,R2L,R3H),
(ZC,R1O,R2L,R3I),(ZC,R1O,R2L,R3J),(ZC,R1O,R2L,R3K),
(ZC,R1O,R2L,R3L),(ZC,R1O,R2L,R3M),(ZC,R1O,R2L,R3N),
(ZC,R1O,R2L,R3O),(ZC,R1O,R2L,R3P),(ZC,R1O,R2L,R3Q),
(ZC,R1O,R2L,R3R),(ZC,R1O,R2M,R3A),(ZC,R1O,R2M,R3B),
(ZC,R1O,R2M,R3C),(ZC,R1O,R2M,R3D),(ZC,R1O,R2M,R3E),
(ZC,R1O,R2M,R3F),(ZC,R1O,R2M,R3G),(ZC,R1O,R2M,R3H),
(ZC,R1O,R2M,R3I),(ZC,R1O,R2M,R3J),(ZC,R1O,R2M,R3K),
(ZC,R1O,R2M,R3L),(ZC,R1O,R2M,R3M),(ZC,R1O,R2M,R3N),
(ZC,R1O,R2M,R3O),(ZC,R1O,R2M,R3P),(ZC,R1O,R2M,R3Q),
(ZC,R1O,R2M,R3R),(ZC,R1O,R2N,R3A),(ZC,R1O,R2N,R3B),
(ZC,R1O,R2N,R3C),(ZC,R1O,R2N,R3D),(ZC,R1O,R2N,R3E),
(ZC,R1O,R2N,R3F),(ZC,R1O,R2N,R3G),(ZC,R1O,R2N,R3H),
(ZC,R1O,R2N,R3I),(ZC,R1O,R2N,R3J),(ZC,R1O,R2N,R3K),
(ZC,R1O,R2N,R3L),(ZC,R1O,R2N,R3M),(ZC,R1O,R2N,R3N),
(ZC,R1O,R2N,R3O),(ZC,R1O,R2N,R3P),(ZC,R1O,R2N,R3Q),
(ZC,R1O,R2N,R3R),(ZC,R1P,R2A,R3A),(ZC,R1P,R2A,R3B),
(ZC,R1P,R2A,R3C),(ZC,R1P,R2A,R3D),(ZC,R1P,R2A,R3E),
(ZC,R1P,R2A,R3F),(ZC,R1P,R2A,R3G),(ZC,R1P,R2A,R3H),
(ZC,R1P,R2A,R3I),(ZC,R1P,R2A,R3J),(ZC,R1P,R2A,R3K),
(ZC,R1P,R2A,R3L),(ZC,R1P,R2A,R3M),(ZC,R1P,R2A,R3N),
(ZC,R1P,R2A,R3O),(ZC,R1P,R2A,R3P),(ZC,R1P,R2A,R3Q),
(ZC,R1P,R2A,R3R),(ZC,R1P,R2B,R3A),(ZC,R1P,R2B,R3B),
(ZC,R1P,R2B,R3C),(ZC,R1P,R2B,R3D),(ZC,R1P,R2B,R3E),
(ZC,R1P,R2B,R3F),(ZC,R1P,R2B,R3G),(ZC,R1P,R2B,R3H),
(ZC,R1P,R2B,R3I),(ZC,R1P,R2B,R3J),(ZC,R1P,R2B,R3K),
(ZC,R1P,R2B,R3L),(ZC,R1P,R2B,R3M),(ZC,R1P,R2B,R3N),
(ZC,R1P,R2B,R3O),(ZC,R1P,R2B,R3P),(ZC,R1P,R2B,R3Q),
(ZC,R1P,R2B,R3R),(ZC,R1P,R2C,R3A),(ZC,R1P,R2C,R3B),
(ZC,R1P,R2C,R3C),(ZC,R1P,R2C,R3D),(ZC,R1P,R2C,R3E),
(ZC,R1P,R2C,R3F),(ZC,R1P,R2C,R3G),(ZC,R1P,R2C,R3H),
(ZC,R1P,R2C,R3I),(ZC,R1P,R2C,R3J),(ZC,R1P,R2C,R3K),
(ZC,R1P,R2C,R3L),(ZC,R1P,R2C,R3M),(ZC,R1P,R2C,R3N),
(ZC,R1P,R2C,R3O),(ZC,R1P,R2C,R3P),(ZC,R1P,R2C,R3Q),
(ZC,R1P,R2C,R3R),(ZC,R1P,R2D,R3A),(ZC,R1P,R2D,R3B),
(ZC,R1P,R2D,R3C),(ZC,R1P,R2D,R3D),(ZC,R1P,R2D,R3E),
(ZC,R1P,R2D,R3F),(ZC,R1P,R2D,R3G),(ZC,R1P,R2D,R3H),
(ZC,R1P,R2D,R3I),(ZC,R1P,R2D,R3J),(ZC,R1P,R2D,R3K),
(ZC,R1P,R2D,R3L),(ZC,R1P,R2D,R3M),(ZC,R1P,R2D,R3N),
(ZC,R1P,R2D,R3O),(ZC,R1P,R2D,R3P),(ZC,R1P,R2D,R3Q),
(ZC,R1P,R2D,R3R),(ZC,R1P,R2E,R3A),(ZC,R1P,R2E,R3B),
(ZC,R1P,R2E,R3C),(ZC,R1P,R2E,R3D),(ZC,R1P,R2E,R3E),
(ZC,R1P,R2E,R3F),(ZC,R1P,R2E,R3G),(ZC,R1P,R2E,R3H),
(ZC,R1P,R2E,R3I),(ZC,R1P,R2E,R3J),(ZC,R1P,R2E,R3K),
(ZC,R1P,R2E,R3L),(ZC,R1P,R2E,R3M),(ZC,R1P,R2E,R3N),
(ZC,R1P,R2E,R3O),(ZC,R1P,R2E,R3P),(ZC,R1P,R2E,R3Q),
(ZC,R1P,R2E,R3R),(ZC,R1P,R2F,R3A),(ZC,R1P,R2F,R3B),
(ZC,R1P,R2F,R3C),(ZC,R1P,R2F,R3D),(ZC,R1P,R2F,R3E),
(ZC,R1P,R2F,R3F),(ZC,R1P,R2F,R3G),(ZC,R1P,R2F,R3H),
(ZC,R1P,R2F,R3I),(ZC,R1P,R2F,R3J),(ZC,R1P,R2F,R3K),
(ZC,R1P,R2F,R3L),(ZC,R1P,R2F,R3M),(ZC,R1P,R2F,R3N),
(ZC,R1P,R2F,R3O),(ZC,R1P,R2F,R3P),(ZC,R1P,R2F,R3Q),
(ZC,R1P,R2F,R3R),(ZC,R1P,R2G,R3A),(ZC,R1P,R2G,R3B),
(ZC,R1P,R2G,R3C),(ZC,R1P,R2G,R3D),(ZC,R1P,R2G,R3E),
(ZC,R1P,R2G,R3F),(ZC,R1P,R2G,R3G),(ZC,R1P,R2G,R3H),
(ZC,R1P,R2G,R3I),(ZC,R1P,R2G,R3J),(ZC,R1P,R2G,R3K),
(ZC,R1P,R2G,R3L),(ZC,R1P,R2G,R3M),(ZC,R1P,R2G,R3N),
(ZC,R1P,R2G,R3O),(ZC,R1P,R2G,R3P),(ZC,R1P,R2G,R3Q),
(ZC,R1P,R2G,R3R),(ZC,R1P,R2H,R3A),(ZC,R1P,R2H,R3B),
(ZC,R1P,R2H,R3C),(ZC,R1P,R2H,R3D),(ZC,R1P,R2H,R3E),
(ZC,R1P,R2H,R3F),(ZC,R1P,R2H,R3G),(ZC,R1P,R2H,R3H),
(ZC,R1P,R2H,R3I),(ZC,R1P,R2H,R3J),(ZC,R1P,R2H,R3K),
(ZC,R1P,R2H,R3L),(ZC,R1P,R2H,R3M),(ZC,R1P,R2H,R3N),
(ZC,R1P,R2H,R3O),(ZC,R1P,R2H,R3P),(ZC,R1P,R2H,R3Q),
(ZC,R1P,R2H,R3R),(ZC,R1P,R2I,R3A),(ZC,R1P,R2I,R3B),
(ZC,R1P,R2I,R3C),(ZC,R1P,R2I,R3D),(ZC,R1P,R2I,R3E),
(ZC,R1P,R2I,R3F),(ZC,R1P,R2I,R3G),(ZC,R1P,R2I,R3H),
(ZC,R1P,R2I,R3I),(ZC,R1P,R2I,R3J),(ZC,R1P,R2I,R3K),
(ZC,R1P,R2I,R3L),(ZC,R1P,R2I,R3M),(ZC,R1P,R2I,R3N),
(ZC,R1P,R2I,R3O),(ZC,R1P,R2I,R3P),(ZC,R1P,R2I,R3Q),
(ZC,R1P,R2I,R3R),(ZC,R1P,R2J,R3A),(ZC,R1P,R2J,R3B),
(ZC,R1P,R2J,R3C),(ZC,R1P,R2J,R3D),(ZC,R1P,R2J,R3E),
(ZC,R1P,R2J,R3F),(ZC,R1P,R2J,R3G),(ZC,R1P,R2J,R3H),
(ZC,R1P,R2J,R3I),(ZC,R1P,R2J,R3J),(ZC,R1P,R2J,R3K),
(ZC,R1P,R2J,R3L),(ZC,R1P,R2J,R3M),(ZC,R1P,R2J,R3N),
(ZC,R1P,R2J,R3O),(ZC,R1P,R2J,R3P),(ZC,R1P,R2J,R3Q),
(ZC,R1P,R2J,R3R),(ZC,R1P,R2K,R3A),(ZC,R1P,R2K,R3B),
(ZC,R1P,R2K,R3C),(ZC,R1P,R2K,R3D),(ZC,R1P,R2K,R3E),
(ZC,R1P,R2K,R3F),(ZC,R1P,R2K,R3G),(ZC,R1P,R2K,R3H),
(ZC,R1P,R2K,R3I),(ZC,R1P,R2K,R3J),(ZC,R1P,R2K,R3K),
(ZC,R1P,R2K,R3L),(ZC,R1P,R2K,R3M),(ZC,R1P,R2K,R3N),
(ZC,R1P,R2K,R3O),(ZC,R1P,R2K,R3P),(ZC,R1P,R2K,R3Q),
(ZC,R1P,R2K,R3R),(ZC,R1P,R2L,R3A),(ZC,R1P,R2L,R3B),
(ZC,R1P,R2L,R3C),(ZC,R1P,R2L,R3D),(ZC,R1P,R2L,R3E),
(ZC,R1P,R2L,R3F),(ZC,R1P,R2L,R3G),(ZC,R1P,R2L,R3H),
(ZC,R1P,R2L,R3I),(ZC,R1P,R2L,R3J),(ZC,R1P,R2L,R3K),
(ZC,R1P,R2L,R3L),(ZC,R1P,R2L,R3M),(ZC,R1P,R2L,R3N),
(ZC,R1P,R2L,R3O),(ZC,R1P,R2L,R3P),(ZC,R1P,R2L,R3Q),
(ZC,R1P,R2L,R3R),(ZC,R1P,R2M,R3A),(ZC,R1P,R2M,R3B),
(ZC,R1P,R2M,R3C),(ZC,R1P,R2M,R3D),(ZC,R1P,R2M,R3E),
(ZC,R1P,R2M,R3F),(ZC,R1P,R2M,R3G),(ZC,R1P,R2M,R3H),
(ZC,R1P,R2M,R3I),(ZC,R1P,R2M,R3J),(ZC,R1P,R2M,R3K),
(ZC,R1P,R2M,R3L),(ZC,R1P,R2M,R3M),(ZC,R1P,R2M,R3N),
(ZC,R1P,R2M,R3O),(ZC,R1P,R2M,R3P),(ZC,R1P,R2M,R3Q),
(ZC,R1P,R2M,R3R),(ZC,R1P,R2N,R3A),(ZC,R1P,R2N,R3B),
(ZC,R1P,R2N,R3C),(ZC,R1P,R2N,R3D),(ZC,R1P,R2N,R3E),
(ZC,R1P,R2N,R3F),(ZC,R1P,R2N,R3G),(ZC,R1P,R2N,R3H),
(ZC,R1P,R2N,R3I),(ZC,R1P,R2N,R3J),(ZC,R1P,R2N,R3K),
(ZC,R1P,R2N,R3L),(ZC,R1P,R2N,R3M),(ZC,R1P,R2N,R3N),
(ZC,R1P,R2N,R3O),(ZC,R1P,R2N,R3P),(ZC,R1P,R2N,R3Q),
(ZC,R1P,R2N,R3R),(ZC,R1Q,R2A,R3A),(ZC,R1Q,R2A,R3B),
(ZC,R1Q,R2A,R3C),(ZC,R1Q,R2A,R3D),(ZC,R1Q,R2A,R3E),
(ZC,R1Q,R2A,R3F),(ZC,R1Q,R2A,R3G),(ZC,R1Q,R2A,R3H),
(ZC,R1Q,R2A,R3I),(ZC,R1Q,R2A,R3J),(ZC,R1Q,R2A,R3K),
(ZC,R1Q,R2A,R3L),(ZC,R1Q,R2A,R3M),(ZC,R1Q,R2A,R3N),
(ZC,R1Q,R2A,R3O),(ZC,R1Q,R2A,R3P),(ZC,R1Q,R2A,R3Q),
(ZC,R1Q,R2A,R3R),(ZC,R1Q,R2B,R3A),(ZC,R1Q,R2B,R3B),
(ZC,R1Q,R2B,R3C),(ZC,R1Q,R2B,R3D),(ZC,R1Q,R2B,R3E),
(ZC,R1Q,R2B,R3F),(ZC,R1Q,R2B,R3G),(ZC,R1Q,R2B,R3H),
(ZC,R1Q,R2B,R3I),(ZC,R1Q,R2B,R3J),(ZC,R1Q,R2B,R3K),
(ZC,R1Q,R2B,R3L),(ZC,R1Q,R2B,R3M),(ZC,R1Q,R2B,R3N),
(ZC,R1Q,R2B,R3O),(ZC,R1Q,R2B,R3P),(ZC,R1Q,R2B,R3Q),
(ZC,R1Q,R2B,R3R),(ZC,R1Q,R2C,R3A),(ZC,R1Q,R2C,R3B),
(ZC,R1Q,R2C,R3C),(ZC,R1Q,R2C,R3D),(ZC,R1Q,R2C,R3E),
(ZC,R1Q,R2C,R3F),(ZC,R1Q,R2C,R3G),(ZC,R1Q,R2C,R3H),
(ZC,R1Q,R2C,R3I),(ZC,R1Q,R2C,R3J),(ZC,R1Q,R2C,R3K),
(ZC,R1Q,R2C,R3L),(ZC,R1Q,R2C,R3M),(ZC,R1Q,R2C,R3N),
(ZC,R1Q,R2C,R3O),(ZC,R1Q,R2C,R3P),(ZC,R1Q,R2C,R3Q),
(ZC,R1Q,R2C,R3R),(ZC,R1Q,R2D,R3A),(ZC,R1Q,R2D,R3B),
(ZC,R1Q,R2D,R3C),(ZC,R1Q,R2D,R3D),(ZC,R1Q,R2D,R3E),
(ZC,R1Q,R2D,R3F),(ZC,R1Q,R2D,R3G),(ZC,R1Q,R2D,R3H),
(ZC,R1Q,R2D,R3I),(ZC,R1Q,R2D,R3J),(ZC,R1Q,R2D,R3K),
(ZC,R1Q,R2D,R3L),(ZC,R1Q,R2D,R3M),(ZC,R1Q,R2D,R3N),
(ZC,R1Q,R2D,R3O),(ZC,R1Q,R2D,R3P),(ZC,R1Q,R2D,R3Q),
(ZC,R1Q,R2D,R3R),(ZC,R1Q,R2E,R3A),(ZC,R1Q,R2E,R3B),
(ZC,R1Q,R2E,R3C),(ZC,R1Q,R2E,R3D),(ZC,R1Q,R2E,R3E),
(ZC,R1Q,R2E,R3F),(ZC,R1Q,R2E,R3G),(ZC,R1Q,R2E,R3H),
(ZC,R1Q,R2E,R3I),(ZC,R1Q,R2E,R3J),(ZC,R1Q,R2E,R3K),
(ZC,R1Q,R2E,R3L),(ZC,R1Q,R2E,R3M),(ZC,R1Q,R2E,R3N),
(ZC,R1Q,R2E,R3O),(ZC,R1Q,R2E,R3P),(ZC,R1Q,R2E,R3Q),
(ZC,R1Q,R2E,R3R),(ZC,R1Q,R2F,R3A),(ZC,R1Q,R2F,R3B),
(ZC,R1Q,R2F,R3C),(ZC,R1Q,R2F,R3D),(ZC,R1Q,R2F,R3E),
(ZC,R1Q,R2F,R3F),(ZC,R1Q,R2F,R3G),(ZC,R1Q,R2F,R3H),
(ZC,R1Q,R2F,R3I),(ZC,R1Q,R2F,R3J),(ZC,R1Q,R2F,R3K),
(ZC,R1Q,R2F,R3L),(ZC,R1Q,R2F,R3M),(ZC,R1Q,R2F,R3N),
(ZC,R1Q,R2F,R3O),(ZC,R1Q,R2F,R3P),(ZC,R1Q,R2F,R3Q),
(ZC,R1Q,R2F,R3R),(ZC,R1Q,R2G,R3A),(ZC,R1Q,R2G,R3B),
(ZC,R1Q,R2G,R3C),(ZC,R1Q,R2G,R3D),(ZC,R1Q,R2G,R3E),
(ZC,R1Q,R2G,R3F),(ZC,R1Q,R2G,R3G),(ZC,R1Q,R2G,R3H),
(ZC,R1Q,R2G,R3I),(ZC,R1Q,R2G,R3J),(ZC,R1Q,R2G,R3K),
(ZC,R1Q,R2G,R3L),(ZC,R1Q,R2G,R3M),(ZC,R1Q,R2G,R3N),
(ZC,R1Q,R2G,R3O),(ZC,R1Q,R2G,R3P),(ZC,R1Q,R2G,R3Q),
(ZC,R1Q,R2G,R3R),(ZC,R1Q,R2H,R3A),(ZC,R1Q,R2H,R3B),
(ZC,R1Q,R2H,R3C),(ZC,R1Q,R2H,R3D),(ZC,R1Q,R2H,R3E),
(ZC,R1Q,R2H,R3F),(ZC,R1Q,R2H,R3G),(ZC,R1Q,R2H,R3H),
(ZC,R1Q,R2H,R3I),(ZC,R1Q,R2H,R3J),(ZC,R1Q,R2H,R3K),
(ZC,R1Q,R2H,R3L),(ZC,R1Q,R2H,R3M),(ZC,R1Q,R2H,R3N),
(ZC,R1Q,R2H,R3O),(ZC,R1Q,R2H,R3P),(ZC,R1Q,R2H,R3Q),
(ZC,R1Q,R2H,R3R),(ZC,R1Q,R2I,R3A),(ZC,R1Q,R2I,R3B),
(ZC,R1Q,R2I,R3C),(ZC,R1Q,R2I,R3D),(ZC,R1Q,R2I,R3E),
(ZC,R1Q,R2I,R3F),(ZC,R1Q,R2I,R3G),(ZC,R1Q,R2I,R3H),
(ZC,R1Q,R2I,R3I),(ZC,R1Q,R2I,R3J),(ZC,R1Q,R2I,R3K),
(ZC,R1Q,R2I,R3L),(ZC,R1Q,R2I,R3M),(ZC,R1Q,R2I,R3N),
(ZC,R1Q,R2I,R3O),(ZC,R1Q,R2I,R3P),(ZC,R1Q,R2I,R3Q),
(ZC,R1Q,R2I,R3R),(ZC,R1Q,R2J,R3A),(ZC,R1Q,R2J,R3B),
(ZC,R1Q,R2J,R3C),(ZC,R1Q,R2J,R3D),(ZC,R1Q,R2J,R3E),
(ZC,R1Q,R2J,R3F),(ZC,R1Q,R2J,R3G),(ZC,R1Q,R2J,R3H),
(ZC,R1Q,R2J,R3I),(ZC,R1Q,R2J,R3J),(ZC,R1Q,R2J,R3K),
(ZC,R1Q,R2J,R3L),(ZC,R1Q,R2J,R3M),(ZC,R1Q,R2J,R3N),
(ZC,R1Q,R2J,R3O),(ZC,R1Q,R2J,R3P),(ZC,R1Q,R2J,R3Q),
(ZC,R1Q,R2J,R3R),(ZC,R1Q,R2K,R3A),(ZC,R1Q,R2K,R3B),
(ZC,R1Q,R2K,R3C),(ZC,R1Q,R2K,R3D),(ZC,R1Q,R2K,R3E),
(ZC,R1Q,R2K,R3F),(ZC,R1Q,R2K,R3G),(ZC,R1Q,R2K,R3H),
(ZC,R1Q,R2K,R31),(ZC,R1Q,R2K,R3J),(ZC,R1Q,R2K,R3K),
(ZC,R1Q,R2K,R3L),(ZC,R1Q,R2K,R3M),(ZC,R1Q,R2K,R3N),
(ZC,R1Q,R2K,R3O),(ZC,R1Q,R2K,R3P),(ZC,R1Q,R2K,R3Q),
(ZC,R1Q,R2K,R3R),(ZC,R1Q,R2L,R3A),(ZC,R1Q,R2L,R3B),
(ZC,R1Q,R2L,R3C),(ZC,R1Q,R2L,R3D),(ZC,R1Q,R2L,R3E),
(ZC,R1Q,R2L,R3F),(ZC,R1Q,R2L,R3G),(ZC,R1Q,R2L,R3H),
(ZC,R1Q,R2L,R3I),(ZC,R1Q,R2L,R3J),(ZC,R1Q,R2L,R3K),
(ZC,R1Q,R2L,R3L),(ZC,R1Q,R2L,R3M),(ZC,R1Q,R2L,R3N),
(ZC,R1Q,R2L,R3O),(ZC,R1Q,R2L,R3P),(ZC,R1Q,R2L,R3Q),
(ZC,R1Q,R2L,R3R),(ZC,R1Q,R2M,R3A),(ZC,R1Q,R2M,R3B),
(ZC,R1Q,R2M,R3C),(ZC,R1Q,R2M,R3D),(ZC,R1Q,R2M,R3E),
(ZC,R1Q,R2M,R3F),(ZC,R1Q,R2M,R3G),(ZC,R1Q,R2M,R3H),
(ZC,R1Q,R2M,R3I),(ZC,R1Q,R2M,R3J),(ZC,R1Q,R2M,R3K),
(ZC,R1Q,R2M,R3L),(ZC,R1Q,R2M,R3M),(ZC,R1Q,R2M,R3N),
(ZC,R1Q,R2M,R3O),(ZC,R1Q,R2M,R3P),(ZC,R1Q,R2M,R3Q),
(ZC,R1Q,R2M,R3R),(ZC,R1Q,R2N,R3A),(ZC,R1Q,R2N,R3B),
(ZC,R1Q,R2N,R3C),(ZC,R1Q,R2N,R3D),(ZC,R1Q,R2N,R3E),
(ZC,R1Q,R2N,R3F),(ZC,R1Q,R2N,R3G),(ZC,R1Q,R2N,R3H),
(ZC,R1Q,R2N,R3I),(ZC,R1Q,R2N,R3J),(ZC,R1Q,R2N,R3K),
(ZC,R1Q,R2N,R3L),(ZC,R1Q,R2N,R3M),(ZC,R1Q,R2N,R3N),
(ZC,R1Q,R2N,R3O),(ZC,R1Q,R2N,R3P),(ZC,R1Q,R2N,R3Q),
(ZC,R1Q,R2N,R3R),(ZC,R1R,R2A,R3A),(ZC,R1R,R2A,R3B),
(ZC,R1R,R2A,R3C),(ZC,R1R,R2A,R3D),(ZC,R1R,R2A,R3E),
(ZC,R1R,R2A,R3F),(ZC,R1R,R2A,R3G),(ZC,R1R,R2A,R3H),
(ZC,R1R,R2A,R3I),(ZC,R1R,R2A,R3J),(ZC,R1R,R2A,R3K),
(ZC,R1R,R2A,R3L),(ZC,R1R,R2A,R3M),(ZC,R1R,R2A,R3N),
(ZC,R1R,R2A,R3O),(ZC,R1R,R2A,R3P),(ZC,R1R,R2A,R3Q),
(ZC,R1R,R2A,R3R),(ZC,R1R,R2B,R3A),(ZC,R1R,R2B,R3B),
(ZC,R1R,R2B,R3C),(ZC,R1R,R2B,R3D),(ZC,R1R,R2B,R3E),
(ZC,R1R,R2B,R3F),(ZC,R1R,R2B,R3G),(ZC,R1R,R2B,R3H),
(ZC,R1R,R2B,R3I),(ZC,R1R,R2B,R3J),(ZC,R1R,R2B,R3K),
(ZC,R1R,R2B,R3L),(ZC,R1R,R2B,R3M),(ZC,R1R,R2B,R3N),
(ZC,R1R,R2B,R3O),(ZC,R1R,R2B,R3P),(ZC,R1R,R2B,R3Q),
(ZC,R1R,R2B,R3R),(ZC,R1R,R2C,R3A),(ZC,R1R,R2C,R3B),
(ZC,R1R,R2C,R3C),(ZC,R1R,R2C,R3D),(ZC,R1R,R2C,R3E),
(ZC,R1R,R2C,R3F),(ZC,R1R,R2C,R3G),(ZC,R1R,R2C,R3H),
(ZC,R1R,R2C,R3I),(ZC,R1R,R2C,R3J),(ZC,R1R,R2C,R3K),
(ZC,R1R,R2C,R3L),(ZC,R1R,R2C,R3M),(ZC,R1R,R2C,R3N),
(ZC,R1R,R2C,R3O),(ZC,R1R,R2C,R3P),(ZC,R1R,R2C,R3Q),
(ZC,R1R,R2C,R3R),(ZC,R1R,R2D,R3A),(ZC,R1R,R2D,R3B),
(ZC,R1R,R2D,R3C),(ZC,R1R,R2D,R3D),(ZC,R1R,R2D,R3E),
(ZC,R1R,R2D,R3F),(ZC,R1R,R2D,R3G),(ZC,R1R,R2D,R3H),
(ZC,R1R,R2D,R3I),(ZC,R1R,R2D,R3J),(ZC,R1R,R2D,R3K),
(ZC,R1R,R2D,R3L),(ZC,R1R,R2D,R3M),(ZC,R1R,R2D,R3N),
(ZC,R1R,R2D,R3O),(ZC,R1R,R2D,R3P),(ZC,R1R,R2D,R3Q),
(ZC,R1R,R2D,R3R),(ZC,R1R,R2E,R3A),(ZC,R1R,R2E,R3B),
(ZC,R1R,R2E,R3C),(ZC,R1R,R2E,R3D),(ZC,R1R,R2E,R3E),
(ZC,R1R,R2E,R3F),(ZC,R1R,R2E,R3G),(ZC,R1R,R2E,R3H),
(ZC,R1R,R2E,R3I),(ZC,R1R,R2E,R3J),(ZC,R1R,R2E,R3K),
(ZC,R1R,R2E,R3L),(ZC,R1R,R2E,R3M),(ZC,R1R,R2E,R3N),
(ZC,R1R,R2E,R3O),(ZC,R1R,R2E,R3P),(ZC,R1R,R2E,R3Q),
(ZC,R1R,R2E,R3R),(ZC,R1R,R2F,R3A),(ZC,R1R,R2F,R3B),
(ZC,R1R,R2F,R3C),(ZC,R1R,R2F,R3D),(ZC,R1R,R2F,R3E),
(ZC,R1R,R2F,R3F),(ZC,R1R,R2F,R3G),(ZC,R1R,R2F,R3H),
(ZC,R1R,R2F,R3I),(ZC,R1R,R2F,R3J),(ZC,R1R,R2F,R3K),
(ZC,R1R,R2F,R3L),(ZC,R1R,R2F,R3M),(ZC,R1R,R2F,R3N),
(ZC,R1R,R2F,R3O),(ZC,R1R,R2F,R3P),(ZC,R1R,R2F,R3Q),
(ZC,R1R,R2F,R3R),(ZC,R1R,R2G,R3A),(ZC,R1R,R2G,R3B),
(ZC,R1R,R2G,R3C),(ZC,R1R,R2G,R3D),(ZC,R1R,R2G,R3E),
(ZC,R1R,R2G,R3F),(ZC,R1R,R2G,R3G),(ZC,R1R,R2G,R3H),
(ZC,R1R,R2G,R3I),(ZC,R1R,R2G,R3J),(ZC,R1R,R2G,R3K),
(ZC,R1R,R2G,R3L),(ZC,R1R,R2G,R3M),(ZC,R1R,R2G,R3N),
(ZC,R1R,R2G,R3O),(ZC,R1R,R2G,R3P),(ZC,R1R,R2G,R3Q),
(ZC,R1R,R2G,R3R),(ZC,R1R,R2H,R3A),(ZC,R1R,R2H,R3B),
(ZC,R1R,R2H,R3C),(ZC,R1R,R2H,R3D),(ZC,R1R,R2H,R3E),
(ZC,R1R,R2H,R3F),(ZC,R1R,R2H,R3G),(ZC,R1R,R2H,R3H),
(ZC,R1R,R2H,R3I),(ZC,R1R,R2H,R3J),(ZC,R1R,R2H,R3K),
(ZC,R1R,R2H,R3L),(ZC,R1R,R2H,R3M),(ZC,R1R,R2H,R3N),
(ZC,R1R,R2H,R3O),(ZC,R1R,R2H,R3P),(ZC,R1R,R2H,R3Q),
(ZC,R1R,R2H,R3R),(ZC,R1R,R2I,R3A),(ZC,R1R,R2I,R3B),
(ZC,R1R,R2I,R3C),(ZC,R1R,R2I,R3D),(ZC,R1R,R2I,R3E),
(ZC,R1R,R2I,R3F),(ZC,R1R,R2I,R3G),(ZC,R1R,R2I,R3H),
(ZC,R1R,R2I,R3I),(ZC,R1R,R2I,R3J),(ZC,R1R,R2I,R3K),
(ZC,R1R,R2I,R3L),(ZC,R1R,R2I,R3M),(ZC,R1R,R2I,R3N),
(ZC,R1R,R2I,R3O),(ZC,R1R,R2I,R3P),(ZC,R1R,R2I,R3Q),
(ZC,R1R,R2I,R3R),(ZC,R1R,R2J,R3A),(ZC,R1R,R2J,R3B),
(ZC,R1R,R2J,R3C),(ZC,R1R,R2J,R3D),(ZC,R1R,R2J,R3E),
(ZC,R1R,R2J,R3F),(ZC,R1R,R2J,R3G),(ZC,R1R,R2J,R3H),
(ZC,R1R,R2J,R3I),(ZC,R1R,R2J,R3J),(ZC,R1R,R2J,R3K),
(ZC,R1R,R2J,R3L),(ZC,R1R,R2J,R3M),(ZC,R1R,R2J,R3N),
(ZC,R1R,R2J,R3O),(ZC,R1R,R2J,R3P),(ZC,R1R,R2J,R3Q),
(ZC,R1R,R2J,R3R),(ZC,R1R,R2K,R3A),(ZC,R1R,R2K,R3B),
(ZC,R1R,R2K,R3C),(ZC,R1R,R2K,R3D),(ZC,R1R,R2K,R3E),
(ZC,R1R,R2K,R3F),(ZC,R1R,R2K,R3G),(ZC,R1R,R2K,R3H),
(ZC,R1R,R2K,R3I),(ZC,R1R,R2K,R3J),(ZC,R1R,R2K,R3K),
(ZC,R1R,R2K,R3L),(ZC,R1R,R2K,R3M),(ZC,R1R,R2K,R3N),
(ZC,R1R,R2K,R3O),(ZC,R1R,R2K,R3P),(ZC,R1R,R2K,R3Q),
(ZC,R1R,R2K,R3R),(ZC,R1R,R2L,R3A),(ZC,R1R,R2L,R3B),
(ZC,R1R,R2L,R3C),(ZC,R1R,R2L,R3D),(ZC,R1R,R2L,R3E),
(ZC,R1R,R2L,R3F),(ZC,R1R,R2L,R3G),(ZC,R1R,R2L,R3H),
(ZC,R1R,R2L,R3I),(ZC,R1R,R2L,R3J),(ZC,R1R,R2L,R3K),
(ZC,R1R,R2L,R3L),(ZC,R1R,R2L,R3M),(ZC,R1R,R2L,R3N),
(ZC,R1R,R2L,R3O),(ZC,R1R,R2L,R3P),(ZC,R1R,R2L,R3Q),
(ZC,R1R,R2L,R3R),(ZC,R1R,R2M,R3A),(ZC,R1R,R2M,R3B),
(ZC,R1R,R2M,R3C),(ZC,R1R,R2M,R3D),(ZC,R1R,R2M,R3E),
(ZC,R1R,R2M,R3F),(ZC,R1R,R2M,R3G),(ZC,R1R,R2M,R3H),
(ZC,R1R,R2M,R3I),(ZC,R1R,R2M,R3J),(ZC,R1R,R2M,R3K),
(ZC,R1R,R2M,R3L),(ZC,R1R,R2M,R3M),(ZC,R1R,R2M,R3N),
(ZC,R1R,R2M,R3O),(ZC,R1R,R2M,R3P),(ZC,R1R,R2M,R3Q),
(ZC,R1R,R2M,R3R),(ZC,R1R,R2N,R3A),(ZC,R1R,R2N,R3B),
(ZC,R1R,R2N,R3C),(ZC,R1R,R2N,R3D),(ZC,R1R,R2N,R3E),
(ZC,R1R,R2N,R3F),(ZC,R1R,R2N,R3G),(ZC,R1R,R2N,R3H),
(ZC,R1R,R2N,R3I),(ZC,R1R,R2N,R3J),(ZC,R1R,R2N,R3K),
(ZC,R1R,R2N,R3L),(ZC,R1R,R2N,R3M),(ZC,R1R,R2N,R3N),
(ZC,R1R,R2N,R3O),(ZC,R1R,R2N,R3P),(ZC,R1R,R2N,R3Q),
(ZC,R1R,R2N,R3R),(ZC,R1S,R2A,R3A),(ZC,R1S,R2A,R3B),
(ZC,R1S,R2A,R3C),(ZC,R1S,R2A,R3D),(ZC,R1S,R2A,R3E),
(ZC,R1S,R2A,R3F),(ZC,R1S,R2A,R3G),(ZC,R1S,R2A,R3H),
(ZC,R1S,R2A,R3I),(ZC,R1S,R2A,R3J),(ZC,R1S,R2A,R3K),
(ZC,R1S,R2A,R3L),(ZC,R1S,R2A,R3M),(ZC,R1S,R2A,R3N),
(ZC,R1S,R2A,R3O),(ZC,R1S,R2A,R3P),(ZC,R1S,R2A,R3Q),
(ZC,R1S,R2A,R3R),(ZC,R1S,R2B,R3A),(ZC,R1S,R2B,R3B),
(ZC,R1S,R2B,R3C),(ZC,R1S,R2B,R3D),(ZC,R1S,R2B,R3E),
(ZC,R1S,R2B,R3F),(ZC,R1S,R2B,R3G),(ZC,R1S,R2B,R3H),
(ZC,R1S,R2B,R3I),(ZC,R1S,R2B,R3J),(ZC,R1S,R2B,R3K),
(ZC,R1S,R2B,R3L),(ZC,R1S,R2B,R3M),(ZC,R1S,R2B,R3N),
(ZC,R1S,R2B,R3O),(ZC,R1S,R2B,R3P),(ZC,R1S,R2B,R3Q),
(ZC,R1S,R2B,R3R),(ZC,R1S,R2C,R3A),(ZC,R1S,R2C,R3B),
(ZC,R1S,R2C,R3C),(ZC,R1S,R2C,R3D),(ZC,R1S,R2C,R3E),
(ZC,R1S,R2C,R3F),(ZC,R1S,R2C,R3G),(ZC,R1S,R2C,R3H),
(ZC,R1S,R2C,R3I),(ZC,R1S,R2C,R3J),(ZC,R1S,R2C,R3K),
(ZC,R1S,R2C,R3L),(ZC,R1S,R2C,R3M),(ZC,R1S,R2C,R3N),
(ZC,R1S,R2C,R3O),(ZC,R1S,R2C,R3P),(ZC,R1S,R2C,R3Q),
(ZC,R1S,R2C,R3R),(ZC,R1S,R2D,R3A),(ZC,R1S,R2D,R3B),
(ZC,R1S,R2D,R3C),(ZC,R1S,R2D,R3D),(ZC,R1S,R2D,R3E),
(ZC,R1S,R2D,R3F),(ZC,R1S,R2D,R3G),(ZC,R1S,R2D,R3H),
(ZC,R1S,R2D,R3I),(ZC,R1S,R2D,R3J),(ZC,R1S,R2D,R3K),
(ZC,R1S,R2D,R3L),(ZC,R1S,R2D,R3M),(ZC,R1S,R2D,R3N),
(ZC,R1S,R2D,R3O),(ZC,R1S,R2D,R3P),(ZC,R1S,R2D,R3Q),
(ZC,R1S,R2D,R3R),(ZC,R1S,R2E,R3A),(ZC,R1S,R2E,R3B),
(ZC,R1S,R2E,R3C),(ZC,R1S,R2E,R3D),(ZC,R1S,R2E,R3E),
(ZC,R1S,R2E,R3F),(ZC,R1S,R2E,R3G),(ZC,R1S,R2E,R3H),
(ZC,R1S,R2E,R3I),(ZC,R1S,R2E,R3J),(ZC,R1S,R2E,R3K),
(ZC,R1S,R2E,R3L),(ZC,R1S,R2E,R3M),(ZC,R1S,R2E,R3N),
(ZC,R1S,R2E,R3O),(ZC,R1S,R2E,R3P),(ZC,R1S,R2E,R3Q),
(ZC,R1S,R2E,R3R),(ZC,R1S,R2F,R3A),(ZC,R1S,R2F,R3B),
(ZC,R1S,R2F,R3C),(ZC,R1S,R2F,R3D),(ZC,R1S,R2F,R3E),
(ZC,R1S,R2F,R3F),(ZC,R1S,R2F,R3G),(ZC,R1S,R2F,R3H),
(ZC,R1S,R2F,R3I),(ZC,R1S,R2F,R3J),(ZC,R1S,R2F,R3K),
(ZC,R1S,R2F,R3L),(ZC,R1S,R2F,R3M),(ZC,R1S,R2F,R3N),
(ZC,R1S,R2F,R3O),(ZC,R1S,R2F,R3P),(ZC,R1S,R2F,R3Q),
(ZC,R1S,R2F,R3R),(ZC,R1S,R2G,R3A),(ZC,R1S,R2G,R3B),
(ZC,R1S,R2G,R3C),(ZC,R1S,R2G,R3D),(ZC,R1S,R2G,R3E),
(ZC,R1S,R2G,R3F),(ZC,R1S,R2G,R3G),(ZC,R1S,R2G,R3H),
(ZC,R1S,R2G,R3I),(ZC,R1S,R2G,R3J),(ZC,R1S,R2G,R3K),
(ZC,R1S,R2G,R3L),(ZC,R1S,R2G,R3M),(ZC,R1S,R2G,R3N),
(ZC,R1S,R2G,R3O),(ZC,R1S,R2G,R3P),(ZC,R1S,R2G,R3Q),
(ZC,R1S,R2G,R3R),(ZC,R1S,R2H,R3A),(ZC,R1S,R2H,R3B),
(ZC,R1S,R2H,R3C),(ZC,R1S,R2H,R3D),(ZC,R1S,R2H,R3E),
(ZC,R1S,R2H,R3F),(ZC,R1S,R2H,R3G),(ZC,R1S,R2H,R3H),
(ZC,R1S,R2H,R3I),(ZC,R1S,R2H,R3J),(ZC,R1S,R2H,R3K),
(ZC,R1S,R2H,R3L),(ZC,R1S,R2H,R3M),(ZC,R1S,R2H,R3N),
(ZC,R1S,R2H,R3O),(ZC,R1S,R2H,R3P),(ZC,R1S,R2H,R3Q),
(ZC,R1S,R2H,R3R),(ZC,R1S,R2I,R3A),(ZC,R1S,R2I,R3B),
(ZC,R1S,R2I,R3C),(ZC,R1S,R2I,R3D),(ZC,R1S,R2I,R3E),
(ZC,R1S,R2I,R3F),(ZC,R1S,R2I,R3G),(ZC,R1S,R2I,R3H),
(ZC,R1S,R2I,R3I),(ZC,R1S,R2I,R3J),
(ZC,R1S,R2I,R3K),(ZC,R1S,R2I,R3L),(ZC,R1S,R2I,R3M),
(ZC,R1S,R2I,R3N),(ZC,R1S,R2I,R3O),(ZC,R1S,R2I,R3P),
(ZC,R1S,R2I,R3Q),(ZC,R1S,R2I,R3R),(ZC,R1S,R2J,R3A),
(ZC,R1S,R2J,R3B),(ZC,R1S,R2J,R3C),(ZC,R1S,R2J,R3D),
(ZC,R1S,R2J,R3E),(ZC,R1S,R2J,R3F),(ZC,R1S,R2J,R3G),
(ZC,R1S,R2J,R3H),(ZC,R1S,R2J,R3I),(ZC,R1S,R2J,R3J),
(ZC,R1S,R2J,R3K),(ZC,R1S,R2J,R3L),(ZC,R1S,R2J,R3M),
(ZC,R1S,R2J,R3N),(ZC,R1S,R2J,R3O),(ZC,R1S,R2J,R3P),
(ZC,R1S,R2J,R3Q),(ZC,R1S,R2J,R3R),(ZC,R1S,R2K,R3A),
(ZC,R1S,R2K,R3B),(ZC,R1S,R2K,R3C),(ZC,R1S,R2K,R3D),
(ZC,R1S,R2K,R3E),(ZC,R1S,R2K,R3F),(ZC,R1S,R2K,R3G),
(ZC,R1S,R2K,R3H),(ZC,R1S,R2K,R3I),(ZC,R1S,R2K,R3J),
(ZC,R1S,R2K,R3K),(ZC,R1S,R2K,R3L),(ZC,R1S,R2K,R3M),
(ZC,R1S,R2K,R3N),(ZC,R1S,R2K,R3O),(ZC,R1S,R2K,R3P),
(ZC,R1S,R2K,R3Q),(ZC,R1S,R2K,R3R),(ZC,R1S,R2L,R3A),
(ZC,R1S,R2L,R3B),(ZC,R1S,R2L,R3C),(ZC,R1S,R2L,R3D),
(ZC,R1S,R2L,R3E),(ZC,R1S,R2L,R3F),(ZC,R1S,R2L,R3G),
(ZC,R1S,R2L,R3H),(ZC,R1S,R2L,R3I),(ZC,R1S,R2L,R3J),
(ZC,R1S,R2L,R3K),(ZC,R1S,R2L,R3L),(ZC,R1S,R2L,R3M),
(ZC,R1S,R2L,R3N),(ZC,R1S,R2L,R3O),(ZC,R1S,R2L,R3P),
(ZC,R1S,R2L,R3Q),(ZC,R1S,R2L,R3R),(ZC,R1S,R2M,R3A),
(ZC,R1S,R2M,R3B),(ZC,R1S,R2M,R3C),(ZC,R1S,R2M,R3D),
(ZC,R1S,R2M,R3E),(ZC,R1S,R2M,R3F),(ZC,R1S,R2M,R3G),
(ZC,R1S,R2M,R3H),(ZC,R1S,R2M,R3I),(ZC,R1S,R2M,R3J),
(ZC,R1S,R2M,R3K),(ZC,R1S,R2M,R3L),(ZC,R1S,R2M,R3M),
(ZC,R1S,R2M,R3N),(ZC,R1S,R2M,R3O),(ZC,R1S,R2M,R3P),
(ZC,R1S,R2M,R3Q),(ZC,R1S,R2M,R3R),(ZC,R1S,R2N,R3A),
(ZC,R1S,R2N,R3B),(ZC,R1S,R2N,R3C),(ZC,R1S,R2N,R3D),
(ZC,R1S,R2N,R3E),(ZC,R1S,R2N,R3F),(ZC,R1S,R2N,R3G),
(ZC,R1S,R2N,R3H),(ZC,R1S,R2N,R3I),(ZC,R1S,R2N,R3J),
(ZC,R1S,R2N,R3K),(ZC,R1S,R2N,R3L),(ZC,R1S,R2N,R3M),
(ZC,R1S,R2N,R3N),(ZC,R1S,R2N,R3O),(ZC,R1S,R2N,R3P),
(ZC,R1S,R2N,R3Q),和(ZC,R1S,R2N,R3R)。
[0121]
本发明的化合物的其它优选实施方案表示为式(g)-(n):
[化学式33]
[表5]
R2 | |
R2O | iPr |
R2P | tBu |
R2Q | cHex |
R2R | Ph |
R2S | 4-OMe-Ph |
R2T | 3-吡啶基 |
R2U | 噻吩基 |
[表6]
R3 | |
R3S | iPr |
R3T | tBu |
R3U | cHex |
R3V | Ph |
R3W | 2-Cl-Ph |
R3X | 2-吡啶基 |
[表7]
A’(仅在式(h),(i),(j),(k),(m)和(n)中 | |
A1 | 2-或3-或4-COOEt |
A2 | 2-或3-或4-CF3 |
A3 | 2-或3-或4-OCF3 |
A4 | 2-或3-或4-SCF3 |
A5 | 2-或3-或4-异噁唑基-3-基 |
A6 | 2-或3-或4-CH=NOH |
A7 | 2-或3-或4-CH=NOMe |
其中
Me为甲基,Et为乙基,iPr为异丙基,tBu为叔丁基,cHex为环己基,Ph为苯基;和
[0122]
R2、R3和A′的组合,例如(R2,R3,A′)为下述组合的任一项:
(R2,R3,A′)=(R2O,R3S,A1),(R2O,R3S,A2),(R2O,R3S,A3),(R2O,R3S,A4),
(R2O,R3S,A5),(R2O,R3S,A6),(R2O,R3S,A7),(R2O,R3T,A1),
(R2O,R3T,A2),(R2O,R3T,A3),(R2O,R3T,A4),(R2O,R3T,A5),
(R2O,R3T,A6),(R2O,R3T,A7),(R2O,R3U,A1),(R2O,R3U,A2),
(R2O,R3U,A3),(R2O,R3U,A4),(R2O,R3U,A5),(R2O,R3U,A6),
(R2O,R3U,A7),(R2O,R3V,A1),(R2O,R3V,A2),(R2O,R3V,A3),
(R2O,R3V,A4),(R2O,R3V,A5),(R2O,R3V,A6),(R2O,R3V,A7),
(R2O,R3W,A1),(R2O,R3W,A2),(R2O,R3W,A3),(R2O,R3W,A4),
(R2O,R3W,A5),(R2O,R3W,A6),(R2O,R3W,A7),(R2O,R3X,A1),
(R2O,R3X,A2),(R2O,R3X,A3),(R2O,R3X,A4),(R2O,R3X,A5),
(R2O,R3X,A6),(R2O,R3X,A7),(R2P,R3S,A1),(R2P,R3S,A2),
(R2P,R3S,A3),(R2P,R3S,A4),(R2P,R3S,A5),(R2P,R3S,A6),(R2P,R3S,A7),
(R2P,R3T,A1),(R2P,R3T,A2),(R2P,R3T,A3),(R2P,R3T,A4),
(R2P,R3T,A5),(R2P,R3T,A6),(R2P,R3T,A7),(R2P,R3U,A1),
(R2P,R3U,A2),(R2P,R3U,A3),(R2P,R3U,A4),(R2P,R3U,A5),
(R2P,R3U,A6),(R2P,R3U,A7),(R2P,R3V,A1),(R2P,R3V,A2),
(R2P,R3V,A3),(R2P,R3V,A4),(R2P,R3V,A5),(R2P,R3V,A6),
(R2P,R3V,A7),(R2P,R3W,A1),(R2P,R3W,A2),(R2P,R3W,A3),
(R2P,R3W,A4),(R2P,R3W,A5),(R2P,R3W,A6),(R2P,R3W,A7),
(R2P,R3X,A1),(R2P,R3X,A2),(R2P,R3X,A3),(R2P,R3X,A4),
(R2P,R3X,A5),(R2P,R3X,A6),(R2P,R3X,A7),(R2Q,R3S,A1),
(R2Q,R3S,A2),(R2Q,R3S,A3),(R2Q,R3S,A4),(R2Q,R3S,A5),
(R2Q,R3S,A6),(R2Q,R3S,A7),(R2Q,R3T,A1),(R2Q,R3T,A2),
(R2Q,R3T,A3),(R2Q,R3T,A4),(R2Q,R3T,A5),(R2Q,R3T,A6),
(R2Q,R3T,A7),(R2Q,R3U,A1),(R2Q,R3U,A2),(R2Q,R3U,A3),
(R2Q,R3U,A4),(R2Q,R3U,A5),(R2Q,R3U,A6),(R2Q,R3U,A7),
(R2Q,R3V,A1),(R2Q,R3V,A2),(R2Q,R3V,A3),(R2Q,R3V,A4),
(R2Q,R3V,A5),(R2Q,R3V,A6),(R2Q,R3V,A7),(R2Q,R3W,A1),
(R2Q,R3W,A2),(R2Q,R3W,A3),(R2Q,R3W,A4),(R2Q,R3W,A5),
(R2Q,R3W,A6),(R2Q,R3W,A7),(R2Q,R3X,A1),(R2Q,R3X,A2),
(R2Q,R3X,A3),(R2Q,R3X,A4),(R2Q,R3X,A5),(R2Q,R3X,A6),
(R2Q,R3X,A7),(R2R,R3S,A1),(R2R,R3S,A2),(R2R,R3S,A3),
(R2R,R3S,A4),(R2R,R3S,A5),(R2R,R3S,A6),(R2R,R3S,A7),
(R2R,R3T,A1),(R2R,R3T,A2),(R2R,R3T,A3),(R2R,R3T,A4),
(R2R,R3T,A5),(R2R,R3T,A6),(R2R,R3T,A7),(R2R,R3U,A1),
(R2R,R3U,A2),(R2R,R3U,A3),(R2R,R3U,A4),(R2R,R3U,A5),
(R2R,R3U,A6),(R2R,R3U,A7),(R2R,R3V,A1),(R2R,R3V,A2),
(R2R,R3V,A3),(R2R,R3V,A4),(R2R,R3V,A5),(R2R,R3V,A6),
(R2R,R3V,A7),(R2R,R3W,A1),(R2R,R3W,A2),(R2R,R3W,A3),
(R2R,R3W,A4),(R2R,R3W,A5),(R2R,R3W,A6),(R2R,R3W,A7),
(R2R,R3X,A1),(R2R,R3X,A2),(R2R,R3X,A3),(R2R,R3X,A4),
(R2R,R3X,A5),(R2R,R3X,A6),(R2R,R3X,A7),(R2S,R3S,A1),
(R2S,R3S,A2),(R2S,R3S,A3),(R2S,R3S,A4),(R2S,R3S,A5),(R2S,R3S,A6),
(R2S,R3S,A7),(R2S,R3T,A1),(R2S,R3T,A2),(R2S,R3T,A3),
(R2S,R3T,A4),(R2S,R3T,A5),(R2S,R3T,A6),(R2S,R3T,A7),
(R2S,R3U,A1),(R2S,R3U,A2),(R2S,R3U,A3),(R2S,R3U,A4),
(R2S,R3U,A5),(R2S,R3U,A6),(R2S,R3U,A7),(R2S,R3V,A1),
(R2S,R3V,A2),(R2S,R3V,A3),(R2S,R3V,A4),(R2S,R3V,A5),
(R2S,R3V,A6),(R2S,R3V,A7),(R2S,R3W,A1),(R2S,R3W,A2),
(R2S,R3W,A3),(R2S,R3W,A4),(R2S,R3W,A5),(R2S,R3W,A6),
(R2S,R3W,A7),(R2S,R3X,A1),(R2S,R3X,A2),(R2S,R3X,A3),
(R2S,R3X,A4),(R2S,R3X,A5),(R2S,R3X,A6),(R2S,R3X,A7),
(R2T,R3S,A1),(R2T,R3S,A2),(R2T,R3S,A3),(R2T,R3S,A4),
(R2T,R3S,A5),(R2T,R3S,A6),(R2T,R3S,A7),(R2T,R3T,A1),
(R2T,R3T,A2),(R2T,R3T,A3),(R2T,R3T,A4),(R2T,R3T,A5),
(R2T,R3T,A6),(R2T,R3T,A7),(R2T,R3U,A1),(R2T,R3U,A2),
(R2T,R3U,A3),(R2T,R3U,A4),(R2T,R3U,A5),(R2T,R3U,A6),
(R2T,R3U,A7),(R2T,R3V,A1),(R2T,R3V,A2),(R2T,R3V,A3),
(R2T,R3V,A4),(R2T,R3V,A5),(R2T,R3V,A6),(R2T,R3V,A7),
(R2T,R3W,A1),(R2T,R3W,A2),(R2T,R3W,A3),(R2T,R3W,A4),
(R2T,R3W,A5),(R2T,R3W,A6),(R2T,R3W,A7),(R2T,R3X,A1),
(R2T,R3X,A2),(R2T,R3X,A3),(R2T,R3X,A4),(R2T,R3X,A5),
(R2T,R3X,A6),(R2T,R3X,A7),(R2U,R3S,A1),(R2U,R3S,A2),
(R2U,R3S,A3),(R2U,R3S,A4),(R2U,R3S,A5),(R2U,R3S,A6),
(R2U,R3S,A7),(R2U,R3T,A1),(R2U,R3T,A2),(R2U,R3T,A3),
(R2U,R3T,A4),(R2U,R3T,A5),(R2U,R3T,A6),(R2U,R3T,A7),
(R2U,R3U,A1),(R2U,R3U,A2),(R2U,R3U,A3),(R2U,R3U,A4),
(R2U,R3U,A5),(R2U,R3U,A6),(R2U,R3U,A7),(R2U,R3V,A1),
(R2U,R3V,A2),(R2U,R3V,A3),(R2U,R3V,A4),(R2U,R3V,A5),
(R2U,R3V,A6),(R2U,R3V,A7),(R2U,R3W,A1),(R2U,R3W,A2),
(R2U,R3W,A3),(R2U,R3W,A4),(R2U,R3W,A5),(R2U,R3W,A6),
(R2U,R3W,A7),(R2U,R3X,A1),(R2U,R3X,A2),(R2U,R3X,A3),
(R2U,R3X,A4),(R2U,R3X,A5),(R2U,R3X,A6),和(R2U,R3X,A7)。
实施例
[0123]
以下具体说明本发明,但并不意欲限定本发明的范围。以下缩写使用如下:
Me:甲基
Et:乙基
Bu:丁基
Ac:乙酰基
TMS:四甲基硅烷
TMS-Cl:氯化三甲基甲硅烷
DMSO:二甲亚砜
r.t.:室温
[0124]
实施例1
5-环己基-4-(2,2-二甲基丙酰基)-3-羟基-1-(4-异噁唑-3-基苯基)-1,5-二氢吡咯-2-酮(I-32)的制备
[化学式34]
向(三甲基乙酰基)丙酮酸乙酯(1.00g,5mmol)、4-异噁唑-3-基-苯胺(0.80g,5mmol)和乙酸(4mL)的混合液中加入环己烷甲醛(0.61mL,5mmol)。在95℃下搅拌该混合物5小时,反应后冷却至r.t.。通过过滤收集沉淀,用乙酸乙酯洗涤并干燥以提供为浅黄色晶体的5-环己基-4-(2,2-二甲基丙酰基)-3-羟基-1-(4-异噁唑-3-基苯基)-1,5-二氢吡咯-2-酮(0.60g,30%)。
熔点:259-260℃、1H-NMR(δppm TMS/DMSO-d6)0.62-1.78(11H,m),1.27(9H,s),5.28(1H,d,J=2.4Hz),7.20(1H,d,J=1.8Hz),7.75(2H,d,J=8.7Hz),7.98(2H,d,J=8.7Hz),9.03(1H,d,J=1.8Hz),11.84(1H,s).
[0125]
实施例2
5-(3-氟苯基)-3-羟基-1-(4-异噁唑-3-基苯基)-4-(4-甲氧基苯甲酰基)-1,5-二氢吡咯-2-酮(I-26)的制备
[化学式35]
向(4-甲氧基苯甲酰基)丙酮酸甲酯(0.24g,1mmol)、4-异噁唑-3-基苯胺(0.16g,1mmol)和二噁烷(1mL)的混合液中添加3-氟苯甲醛(0.11mL,1mmol)。在r.t.下搅拌该混合物2天。然后将二乙醚(3mL)添加至该混合物,并通过过滤收集沉淀以提供为浅黄色结晶的5-(3-氟苯基)-3-羟基-1-(4-异噁唑-3-基苯基)-4-(4-甲氧基苯甲酰基)-1,5-二氢吡咯-2-酮(0.16g,34%)。
熔点:273-274℃(分解),1H-NMR(δppm TMS/DMSO-d6)3.83(3H,s),6.43(1H,s),6.90-7.02(3H,m),7.11(1H,d,J=1.7Hz),7.23-7.35(3H,m),7.75-7.87(6H,m),8.97(1H,d,J=1.7Hz),11.75(1H,brs)。
[0126]
实施例3
3-叔丁基-4-环己基-5-(4-异噁唑-3-基苯基)-4,5-二氢-1H-吡咯并[3,4-c]吡唑-6-酮(I-96)的制备
[化学式36]
向5-环己基-4-(2,2-二甲基丙酰基)-3-羟基-1-(4-异噁唑-3-基苯基)-1,5-二氢吡咯-2-酮(0.10g,0.25mmol)和乙酸(1mL)的混合液中添加一水合肼(0.036mL,0.75mmol)。在85℃下搅拌该混合物3小时。将水(80mL)添加至该混合物,然后用乙酸乙酯萃取(100mL)。用饱和碳酸氢钠水溶液(80mL×2)洗涤有机层,以无水硫酸镁干燥,并在减压下浓缩。通过硅胶柱色谱(乙酸乙酯/正己烷)纯化所得的残渣。自乙酸乙酯重结晶粗制品以提供为无色结晶的3-叔丁基-4-环己基-5-(4-异噁唑-3-基苯基)-4,5-二氢-1H-吡咯并[3,4-c]吡唑-6-酮(0.072g,71%)。
熔点:251-252℃、1H-NMR(δppm TMS/DMSO-d6)0.50-2.03(11H,m),1.39(9H,s),5.60(1H,s),7.20(1H,d,J=1.8Hz),7.72(2H,d,J=8.7Hz),7.96(2H,d,J=8.7Hz),9.02(1H,d,J=1.8Hz),13.28(1H,s)。
[0127]
实施例4
4-(1-乙基丙基)-5-(4-异噁唑-3-基苯基)-3-(6-氧代-1,6-二氢吡啶-3-基)-4,5-二氢-1H-吡咯并[3,4-c]吡唑-6-酮(I-198)的制备
[化学式37]
向4-(1-乙基丙基)-5-(4-异噁唑-3-基苯基)-3-(6-甲氧基吡啶-3-基)-4,5-二氢-1H-吡咯并[3,4-c]吡唑-6-酮(0.067g,0.15mmol)和碘化钠(0.067g,0.45mmol)在乙腈(3mL)的混合液中添加氯化三甲基甲硅烷(0.058mL,0.45mmol)。在回流搅拌下加热该混合物1小时。将水(50mL)和乙酸乙酯(50mL)添加至该混合物,并通过过滤收集沉淀,进行干燥以提供为浅黄色晶体的4-(1-乙基丙基)-5-(4-异噁唑-3-基苯基)-3-(6-氧代-1,6-二氢吡啶-3-基)-4,5-二氢-1H-吡咯并[3,4-c]吡唑-6-酮(0.041g,64%)。
熔点:>290℃(分解),1H-NMR(δppm TMS/DMSO-d6)0.50-1.55(11H,m),6.00(1H,d,J=2.5Hz),6.49(1H,d,J=9.4Hz),7.18(1H,d,J=1.8Hz),7.70-7.90(4H,m),8.01(2H,d,J=8.4Hz),9.02(1H,d,J=1.8Hz),12.04(1H,brs),13.78(1H,brs)。
[0128]
实施例5
3-羟基-4-(4-甲氧基苯甲酰基)-1-(4-甲氧基亚氨基甲基苯基)-5-苯基-1,5-二氢吡咯-2-酮(I-199)的制备
[化学式38]
向3-羟基-1-(4-羟甲基苯基)-4-(4-甲氧基苯甲酰基)-5-苯基-1,5-二氢吡咯-2-酮(0.125g,0.3mmol)和丙酮(20mL)的混合液中添加氧化锰(IV)(0.625g,7.18mmol)。在r.t.下搅拌该混合物2.5小时。进一步将氧化锰(IV)(0.625g,7.18mmol)添加至该混合物,并在r.t.下搅拌该混合物4.5小时。反应后,通过C盐(celite)过滤除去不溶的氧化锰(IV),在减压下浓缩滤液以提供1-(4-甲酰苯基)-3-羟基-4-(4-甲氧基苯甲酰基)-5-苯基-1,5-二氢吡咯-2-酮的粗制品。添加甲醇以制备0.1M该粗制品的甲醇溶液。
[0129]
向0.1M的1-(4-甲酰苯基)-3-羟基-4-(4-甲氧基苯甲酰基)-5-苯基-1,5-二氢吡咯-2-酮的甲醇溶液(1mL,0.1mmol)中添加O-甲基羟基氯化铵(0.025g,0.3mmol)和乙酸钠(0.025g,0.3mmol)。在回流下搅拌该混合物3小时。将水(50mL)添加至该混合物,然后用乙酸乙酯(50mL)萃取。用饱和盐水(50mL)洗涤有机层,以无水硫酸镁干燥,并在减压下浓缩。向残渣中添加乙酸乙酯并通过过滤收集沉淀,干燥以提供为浅黄色晶体的3-羟基-4-(4-甲氧基苯甲酰基)-1-(4-甲氧基亚氨基甲基苯基)-5-苯基-1,5-二氢吡咯-2-酮(1.3mg,3%)。
熔点:226-229℃、1H-NMR(δppm TMS/DMSO-d6)3.82(3H,s),3.85(3H,s),6.31(1H,s),6.95-7.75(13H,m),8.12(1H,s),11.63(1H,brs)。
[0130]
实施例6
1-(1,3-二氧戊环-2-基)-3-羟基-4-(4-甲氧基苯甲酰基)-5-苯基-1,5-二氢吡咯-2-酮(I-200)的制备
[化学式39]
在减压下浓缩0.1M的1-(4-甲酰苯基)-3-羟基-4-(4-甲氧基苯甲酰基)-5-苯基-1,5-二氢吡咯-2-酮的甲醇溶液(1mL,0.1mmol)。然后将甲苯(1mL),乙二醇(0.033mL,0.6mmol)和对甲苯磺酸一水化物(3.8mg,0.02mmol)添加至残渣。进行3小时共沸脱水。将水(100mL)添加至该混合物,然后用乙酸乙酯(100mL)萃取。用饱和盐水(100mL)洗涤有机层,以无水硫酸镁干燥后,在减压下浓缩。向所得残渣中添加乙酸乙酯并通过过滤收集沉淀,干燥以提供为浅黄色晶体的1-(1,3-二氧戊环-2-基)-3-羟基-4-(4-甲氧基苯甲酰基)-5-苯基-1,5-二氢吡咯-2-酮(3.8mg,8%)。
熔点:216-219℃,1H-NMR(δppm TMS/DMSO-d6)3.81(3H,s),3.89-4.00(4H,m),5.63(1H,s),6.26(1H,s),6.94-7.75(13H,m),11.65(1H,brs).
[0131]
实施例7
3-羟基-1-(4-异噁唑-3-基苯基)-4-(4-甲氧基苯甲酰基)-5-(4-哌啶)-1,5-二氢吡咯-2-酮盐酸盐(I-201)的制备
[化学式40]
向5-(1-叔丁氧基羰基-4-哌啶)-3-羟基-1-(4-异噁唑-3-基苯基)-4-(4-甲氧基苯甲酰基)-1,5-二氢吡咯-2-酮(0.112g,0.2mmol)和甲醇(1mL)的混合液中添加盐酸的二噁烷溶液(4mol/L,0.2mL,0.8mmol)并在r.t.下搅拌该混合物2.5小时。再向所述混合物中添加盐酸的二噁烷溶液(4mol/L,0.2mL,0.8mmol),并在回流下再搅拌该混合物0.5小时。反应后,在减压下浓缩该混合物以提供为浅褐色晶体的3-羟基-1-(4-异噁唑-3-基苯基)-4-(4-甲氧基苯甲酰基)-5-(4-哌啶)-1,5-二氢吡咯-2-酮盐酸盐(0.098g,100%)。
1H-NMR(δppm TMS/DMSO-d6)1.25-2.09(5H,m),2.50-2.74(2H,m),3.09-3.17(2H,m),3.90(3H,s),5.58(1H,s),7.09(2H,d,J=8.6Hz),7.21(1H,d,J=1.5Hz),7.82-7.89(4H,m),8.02(2H,d,J=8.6Hz),8.11(1H,brs),8.58(1H,brs),9.04(1H,d,J=1.5Hz),11.55(1H,brs)。
[0132]
实施例8
3-(4-甲氧基苯基)-5-(4-噁唑-2-基苯基)-4-苯基-4,5-二氢-1H-吡咯并[3,4-c]吡唑-6-酮(I-247)的制备
[化学式41]
在130℃、在微波辐射下,搅拌5-(4-溴苯基)-3-(4-甲氧基苯基)-4-苯基-4,5-二氢-1H-吡咯并[3,4-c]吡唑-6-酮(0.138g,0.3mmol)、噁唑-2-基三丁基锡(0.134g,0.37mmol)、三(2-呋喃基)膦(0.014g,0.06mmol)、三(二亚苄基丙酮)二钯(0)(0.027g,0.03mmol)和二噁烷(1.5mL)的混合液75分钟。通过硅胶柱色谱(乙酸乙酯/正己烷)纯化反应混合物。在减压下浓缩馏分并通过过滤收集沉淀以提供为无色晶体的3-(4-甲氧基苯基)-5-(4-噁唑-2-基苯基)-4-苯基-4,5-二氢-1H-吡咯并[3,4-c]吡唑-6-酮(12mg,10%)。
1H-NMR(δppm TMS/DMSO-d6)3.75(3H,s),6.86(1H,s),6.91-7.92(13H,m),8.17(1H,s),14.00(1H,brs)。
[0133]
实施例9
5-环己基-3-羟基-1-(4-异噁唑-3-基苯基)-4-(4-羧基苯甲酰基)-1,5-二氢吡咯-2-酮的制备
[化学式42]
向5-环己基-3-羟基-1-(4-异噁唑-3-基苯基)-4-(4-甲氧基羧基苯甲酰基)-1,5-二氢吡咯-2-酮(1.98g,4.07mmol)、THF(20mL)和甲醇(13mL)的混合液中添加2N氢氧化钠水溶液(5.09mL)。在80℃油浴中搅拌该混合物2小时。反应后,在冰冷条件下向该混合物中添加2N盐酸(5.09mL),然后添加乙酸乙酯和水。将该混合物在r.t.下放置一夜。通过过滤收集沉淀以提供为黄色晶体的5-环己基-3-羟基-1-(4-异噁唑-3-基苯基)-4-(4-羧基苯甲酰基)-1,5-二氢吡咯-2-酮(1.70g,88%)。
1H-NMR(δppm TMS/DMSO-d6)0.73-1.80(11H,m),5.49(1H,d,J=2.4Hz),7.21(1H,d,J=1.7Hz),7.80-8.11(8H,m),9.04(1H,d,J=1.7Hz)。
[0134]
实施例10
5-环己基-3-羟基-1-(4-异噁唑-3-基苯基)-4-(4-甲基氨甲酰基苯甲酰基)-1,5-二氢吡咯-2-酮的制备
[化学式43]
向5-环己基-3-羟基-1-(4-异噁唑-3-基苯基)-4-(4-羧基苯甲酰基)-1,5-二氢吡咯-2-酮(0.095g,0.2mmol)和DMF(2mL)的混合液中添加盐酸甲胺(0.020g,0.3mmol)、1-羟基苯并三唑(0.041g,0.3mmol)、4-二甲基氨基吡啶(0.005g,0.04mmol)、1-乙基-3-(3-二甲基氨基丙基)碳二亚胺盐酸盐(0.058g,0.3mmol)和三乙胺(0.042mL,0.3mmol)。在r.t.下搅拌该混合物1小时。添加乙酸乙酯和水,并通过过滤收集沉淀以提供为浅黄色晶体的5-环己基-3-羟基-1-(4-异噁唑-3-基苯基)-4-(4-甲基氨甲酰基苯甲酰基)-1,5-二氢吡咯-2-酮(0.062g,64%)。
1H-NMR(δppm TMS/DMSO-d6)0.72-1.80(11H,m),2.81(3H,d,J=4.5Hz),5.48(1H,d,J=2.5Hz),7.21(1H,d,J=1.7Hz),7.80-8.03(8H,m),8.64(1H,d,J=4.5Hz),9.04(1H,d,J=1.7Hz),11.73(1H,brs)。
[0135]
实施例11
3-叔丁基-5-(4-异噁唑-4-基苯基)-4-(2-甲氧基苯基)-4,5-二氢-1H-吡咯并[3,4-c]吡唑-6-酮的制备
[化学式44]
在氮气氛下向5-(4-溴苯基)-3-叔丁基-4-(2-甲氧基苯基)-4,5-二氢-1H-吡咯并[3,4-c]吡唑-6-酮(0.10g,0.23mmol)、4-(4,4,5,5-四甲基-1,3-2-二氧硼戊环(dioxaborolan)-2-基)异噁唑(0.066g,0.34mmol)、磷酸三钾(0.145g,0.68mmol)、乙二醇二甲醚(3mL)和水(0.6mL)的混合液中添加[1,1’-双(二苯基膦基)二茂铁]二氯钯(II)二氯甲烷络合物(0.018g,0.023mmol),并在回流下搅拌该混合物4小时。通过硅胶柱色谱(乙酸乙酯/正己烷)纯化该混合物以提供为无色晶体的3-叔丁基-5-(4-异噁唑-4-基苯基)-4-(2-甲氧基苯基)-4,5-二氢-1H-吡咯并[3,4-c]吡唑-6-酮(0.012g,12%)。
1H-NMR(δppm TMS/DMSO-d6)1.05(9H,s),3.91(3H,s),6.22-7.61(9H,m),9.09(1H,s),9.36(1H,s),13.34(1H,s)。
[0136]
实施例12
3-叔丁基-5-(4-呋喃-3-基苯基)-4-(2-甲氧基苯基)-4,5-二氢-1H-吡咯并[3,4-c]吡唑-6-酮的制备
[化学式45]
在氮气氛下向5-(4-溴苯基)-3-叔丁基-4-(2-甲氧基苯基)-4,5-二氢-1H-吡咯并[3,4-c]吡唑-6-酮(0.10g,0.23mmol)、呋喃-3-基硼酸(0.038g,0.34mmol)、磷酸三钾(0.096g,0.45mmol)和丁醇(1mL)的混合液中添加(2′,4′,6′-三异丙基联苯-2-基)膦(0.009g,0.02mmol)和三(二亚苄基丙酮)二钯(0)(0.004g,0.004mmol),并在回流下搅拌该混合物3小时。通过硅胶柱色谱(乙酸乙酯/正己烷)纯化反应混合物。在减压下浓缩馏分并通过过滤收集沉淀以提供为无色晶体的3-叔丁基-5-(4-呋喃-3-基苯基)-4-(2-甲氧基苯基)-4,5-二氢-1H-吡咯并[3,4-c]吡唑-6-酮(0.061g,63%)。
1H-NMR(δppm TMS/DMSO-d6)1.05(9H,s),3.90(3H,s),6.37-7.56(10H,m),7.70(1H,s),8.11(1H,s),13.32(1H,s)。
[0137]
实施例13
5-环己基-3-羟基-4-(4-羟基苯甲酰基)-1-(4-异噁唑-3-基苯基)-1,5-二氢吡咯-2-酮的制备
[化学式46]
在冰冷条件下向5-环己基-3-羟基-1-(4-异噁唑-3-基苯基)-4-(4-甲氧基苯甲酰基)-1,5-二氢吡咯-2-酮(0.229g,0.5mmol)和二氯甲烷(10mL)的混合液中添加1M三溴化硼的二氯甲烷溶液(5.0mL,5mmol),并在r.t.下搅拌该混合物3天。反应后,在冰冷条件下添加少量的碳酸钾以降解过量的三溴化硼。添加1N氢氧化钠水溶液后用乙酸乙酯洗涤该混合物。用1N盐酸中和水层,通过过滤收集沉淀并用热乙酸乙酯洗涤以提供为无色晶体的5-环己基-3-羟基-4-(4-羟基苯甲酰基)-1-(4-异噁唑-3-基苯基)-1,5-二氢吡咯-2-酮(0.068g,31%)。
1H-NMR(δppm TMS/DMSO-d6)0.73-1.80(11H,m),5.41(1H,d,J=2.5Hz),6.88-6.91(2H,m),7.20(1H,d,J=1.7Hz),7.78-8.01(6H,m),9.03(1H,d,J=1.7Hz),10.42(1H,brs),11.14(1H.brs)。
[0138]
实施例14
5-环己基-3-羟基-4-(4-羟甲基苯甲酰基)-1-(4-异噁唑-3-基苯基)-1,5-二氢吡咯-2-酮的制备
[化学式47]
向4-(2-四氢-2H-吡喃氧基甲基)苯甲酰基丙酮酸甲酯(0.17g,0.53mmol)、4-异噁唑-3-基苯胺(0.085g,0.53mmol)和乙酸(1mL)的混合液中添加环己烷甲醛(0.064mL,0.53mmol)。在95℃下搅拌该混合物0.5小时。反应后冷却至r.t.。通过过滤收集沉淀并用乙酸乙酯洗涤以提供粗产物。向该粗产物中添加甲醇(5mL)、THF(5mL)和对甲苯磺酸吡啶鎓盐(0.027g,0.11mmol),并在60℃下搅拌该混合物0.5小时。在该混合物中添加水,然后用氯仿萃取。以无水硫酸镁干燥有机层并在减压下浓缩。自乙酸乙酯重结晶残渣以提供为无色晶体的5-环己基-3-羟基-4-(4-羟甲基苯甲酰基)-1-(4-异噁唑-3-基苯基)-1,5-二氢吡咯-2-酮(0.022g,9%)。
1H-NMR(δppm TMS/DMSO-d6)0.62-1.78(11H,m),4.61(2H,d,J=5.6Hz),5.38(1H,t,J=5.6Hz),5.47(1H,d,J=2.0Hz),7.21(1H,d,J=1.7Hz),7.49-8.02(8H,m),9.03(1H,d,J=1.7Hz),11.40(1H,brs)。
[0139]
一般制备方法1
经分离的对映体的制备
[化学式48]
其中,所有符号均为如上定义。
在合适溶剂中,使化合物(I′-1)和光学拆分试剂(例如:(S)-2-羟基-2-苯基乙酸甲酯)与缩合剂(例如:偶氮二甲酸异丙酯)反应,并通过常规方法(例如:柱色谱、重结晶等)纯化所得的混合物,以分离具有期望立体构造的非对映体。对所得非对映体进行脱保护(例如:氢化)以制备目标对映体。所述光学拆分试剂相对于化合物(I′-1)使用1-4当量,优选为1-2.5当量的量。
[0140]
可以使用的溶剂包括芳烃(例如:甲苯、苯、二甲苯等)、饱和烃(例如:环己烷、己烷等)、醚(例如:四氢呋喃、二乙醚、二噁烷等)、酰胺(例如:二甲基甲酰胺、二甲基乙酰胺、N-甲基吡咯烷酮)和它们的混合溶剂等。
[0141]
反应温度可以为-10℃~150℃,优选为0℃~50℃。尽管反应时间取决于所使用的化合物,但其可以为10分钟-48小时。
[0142]
根据一般制造方法1,制备了下述化合物。
实施例15
(+)-4-(2,2-二甲基丙酰基)-3-羟基-1-(4-异噁唑-3-基苯基)-5-(2-甲氧基苯基)-1,5-二氢吡咯-2-酮的制备
[化学式49]
在冰冷下向4-(2,2-二甲基丙酰基)-3-羟基-1-(4-异噁唑-3-基苯基)-5-(2-甲氧基苯基)-1,5-二氢吡咯-2-酮(0.43g,1mmol)、(S)-2-羟基-2-苯基乙酸甲酯(0.23g,1.4mmol)、三苯基膦(0.34g,1.3mmol)和THF(10mL)的混合液中添加偶氮二甲酸异丙酯(0.26mL,1.3mmol),并在r.t.下搅拌该混合物0.5小时。在减压下浓缩该反应混合物。通过硅胶柱色谱(乙酸乙酯/正己烷)纯化残渣以获得非对映体混合物,然后将其自乙酸乙酯/正己烷重结晶以提供为无色晶体的非对映体(0.14g,25%)。
向所得非对映体(0.058g,0.1mmol)的二噁烷(3mL)溶液中添加10%钯-碳(0.026g)。在r.t.下氢化该混合物2小时。通过C盐过滤反应混合物并在减压下浓缩滤液。通过硅胶柱色谱(乙酸乙酯/正己烷)纯化残渣以提供为无色晶体的(+)-4-(2,2-二甲基丙酰基)-3-羟基-1-(4-异噁唑-3-基苯基)-5-(2-甲氧基苯基)-1,5-二氢吡咯-2-酮(0.043g,100%,光学纯度:100%ee)。
[α]D:+62.5±2.0°(CHCl3中),1H-NMR(δppm TMS/DMSO-d6)1.10(9H,s),3.89(3H,brs),6.39(1H,brs),6.70-7.82(9H,m),8.95(1H,d,J=1.8Hz),12.08(1H,brs)。
[0143]
一般制备方法2
噁唑体的制备
[化学式50]
其中,X为卤素;所有其它符号均如上定义。
通过使化合物(I′-2)、羟亚氨基卤化物和碱在合适的溶剂中反应来制备。根据需要,可按常规方法(例如:柱色谱、重结晶等)纯化所得化合物。所述羟亚氨基卤化物相对于化合物(I′-2)使用1-5当量,优选1-2.5当量的量。
[0144]
可以使用的溶剂包括芳烃(例如:甲苯、苯、二甲苯等)、饱和烃(例如:环己烷、己烷等)、醚(例如:四氢呋喃、二乙醚、二噁烷等)、酰胺(例如:二甲基甲酰胺、二甲基乙酰胺、N-甲基吡咯烷酮)和它们的混合溶剂等。
[0145]
可以使用的碱包括:例如金属氢氧化物(例如:氢氧化钠、氢氧化钾等)、金属氢化物(例如:氢化钠、氢化锂等)、金属碳酸盐(例如:碳酸钠、碳酸钾、碳酸铯等)等,它们相对于化合物(I′-2)可以使用2当量或以上,优选2-10当量的量。
[0146]
反应温度可以为-40℃~150℃,优选为0℃~50℃。尽管反应时间取决于所使用的化合物,但其可以为10分钟-48小时。
[0147]
根据上述一般制备方法2,制备了下述化合物。
实施例16
3-叔丁基-5-[4-(3-乙氧基羰基-5-异噁唑基)苯基]-4-(2-甲氧基苯基)-4,5-二氢-1H-吡咯并[3,4-c]吡唑-6-酮的制备
[化学式51]
在冰冷条件下,向3-叔丁基-5-(4-乙炔基苯基)-4-(2-甲氧基苯基)-4,5-二氢-1H-吡咯并[3,4-c]吡唑-6-酮(1.51g,3.9mmol)、2-氯-2-羟亚氨基乙酸乙酯(1.19g,7.8mmol)和THF(4mL)的混合液中滴加三乙胺(1.09mL,7.8mmol)的THF(3mL)溶液,并在0℃下搅拌该混合物4小时。添加2-氯-2-羟亚氨基乙酸乙酯(1.19g,7.8mmol),并进一步滴加三乙胺(0.81mL,5.9mmol)的THF(3mL)溶液。在0℃下搅拌该混合物2小时并放置过夜。通过过滤除去沉淀,在减压下浓缩滤液。通过纯化残渣以提供为无色固体的3-叔丁基-5-[4-(3-乙氧基羰基-5-异噁唑基)苯基]-4-(2-甲氧基苯基)-4,5-二氢-1H-吡咯并[3,4-c]吡唑-6-酮(1.26g,64%)。
1H-NMR(δppm TMS/DMSO-d6)1.13(9H,s),1.43(3H,t,J=7.1),3.50(0.5H,s),4.01(2.5H,s),4.45(2H,q,J=7.3),6.01(0.3H,s),6.74-6.88(2.7H,m),6.91(1H,d,J=8.6),7.19(1H,t,J=7.4),7.70(2H,d,J=8.6),7.81(2H,d,J=8.6)。
[0148]
实施例17
3-叔丁基-5-[4-(3-羧基-5-异噁唑基)苯基]-4-(2-甲氧基苯基)-4,5-二氢-1H-吡咯并[3,4-c]吡唑-6-酮的制备
[化学式52]
向3-叔丁基-5-[4-(3-乙氧基羰基-5-异噁唑基)苯基]-4-(2-甲氧基苯基)-4,5-二氢-1H-吡咯并[3,4-c]吡唑-6-酮(1.26g,2.5mmol)、甲醇(4mL)、THF(4mL)和水(3mL)的混合液中添加2N氢氧化钠水溶液(1.5mL,3mmol),并在50℃下搅拌该混合物1小时。对该混合物添加水(40mL)和1N盐酸(2mL),然后用乙酸乙酯萃取。用饱和盐水洗涤有机层,以无水硫酸钠干燥,并在减压下浓缩。将粗制品悬浮于醚中并收集沉淀以提供为浅黄色晶体的3-叔丁基-5-[4-(3-羧基-5-异噁唑基)苯基]-4-(2-甲氧基苯基)-4,5-二氢-1H-吡咯并[3,4-c]吡唑-6-酮(0.84g,71%)。
1H-NMR(δppm TMS/DMSO-d6)1.05(9H,s),3.96(3H,s),6.50(0.3H,s),6.68-6.94(2.7H,m),7.00-7.25(2H,m),7.29(1H,s),7.77(2H,d,J=8.6),7.87(2H,d,J=8.6),13.43(1H,brs),13.97(1H,brs)。
[0149]
实施例18
3-叔丁基-5-[4-(3-二甲基氨甲酰基-5-异噁唑基)苯基]-4-(2-甲氧基苯基)-4,5-二氢-1H-吡咯并[3,4-c]吡唑-6-酮的制备
[化学式53]
向3-叔丁基-5-[4-(3-羧基-5-异噁唑基)苯基]-4-(2-甲氧基苯基)-4,5-二氢-1H-吡咯并[3,4-c]吡唑-6-酮(0.080g,0.17mmol)和DMF(2mL)的混合液中添加盐酸二甲胺(0.021g,0.25mmol)、1-羟基苯并三唑(0.034g,0.25mmol)、4-二甲基氨基吡啶(0.004g,0.03mmol)、1-乙基-3-(3-二甲基氨基丙基)碳二亚胺盐酸盐(0.048g,0.25mmol)和三乙胺(0.035mL,0.25mmol),并在r.t.下搅拌该混合物2小时。对该混合物添加乙酸乙酯和水,并通过过滤收集沉淀以提供为浅黄色晶体的5-环己基-3-羟基-1-(4-异噁唑-3-基苯基)-4-(4-甲基氨甲酰基苯甲酰基)-1,5-二氢吡咯-2-酮(0.055g,65%)。
1H-NMR(δppm TMS/DMSO-d6)1.05(9H,s),3.02(3H,s),3.39(1H,s),6.50(0.3H,m),6.65-6.96(2.7H,m),7.06(1H,d,J=8.1),7.14(1H,s),7.19(1H,t,J=7.6),7.76(2H,d,J=8.6),7.84(2H,d,J=8.6),13.32(1H,brs)。
[0150]
实施例19
3-叔丁基-5-[4-(3-羟甲基-5-异噁唑基)苯基]-4-(2-甲氧基苯基)-4,5-二氢-1H-吡咯并[3,4-c]吡唑-6-酮的制备
[化学式54]
在冰冷条件下,向3-叔丁基-5-[4-(3-羧基-5-异噁唑基)苯基]-4-(2-甲氧基苯基)-4,5-二氢-1H-吡咯并[3,4-c]吡唑-6-酮(0.080g,0.17mmol)、三乙胺(0.031mL,0.22mmol)和THF(2mL)的混合液中添加氯碳酸乙酯(0.019mL,0.20mmol),并在r.t.下搅拌2小时。对该混合物添加硼氢化钠(0.026g,0.68mmol)、水(0.3mL)和甲醇(1mL),并在r.t.下搅拌该混合物10分钟。对该混合物添加水,用乙酸乙酯萃取该混合物。然后用1N盐酸、饱和碳酸氢钠和饱和盐水洗涤有机层,以无水硫酸钠干燥并在减压下浓缩。将残渣用二氯甲烷、二乙醚和乙酸乙酯结晶,并通过过滤收集沉淀以提供为无色晶体的3-叔丁基-5-[4-(3-羟甲基-5-异噁唑基)苯基]-4-(2-甲氧基苯基)-4,5-二氢-1H-吡咯并[3,4-c]吡唑-6-酮(0.068g,88%)。
1H-NMR(δppm TMS/DMSO-d6)1.03(9H,s),3.39(1H,s),3.94(2H,s),4.51(2H,d,J=26.9),5.52(1H,t,J=5.8),6.47(0.3H,s),6.65-6.84(2.7H,m),6.88(1H,s),7.05(1H,d,J=8.1),7.19(1H,t,J=7.6),7.73(2H,d,J=8.6),7.78(2H,d,J=8.6),13.13(0.3H,brs),13.39(0.6H,brs),13.58(0.1H,brs)。
[0151]
一般制备方法3
经Boc-保护的胺的制备
[化学式55]
其中,所有符号均为如上定义。
使化合物(I′-3)、碱和叠氮化试剂(例如:二苯基磷酰基叠氮)在合适的溶剂中反应,然后添加叔丁醇和干燥剂(例如:硫酸钠、分子筛粉末)。根据需要,可按照常规方法(例如:柱色谱、重结晶、萃取等)纯化所得化合物。所述叠氮化试剂相对于化合物(I′-3)使用1-4当量,优选1-2.5当量的量。
[0152]
可以使用的溶剂包括芳烃(例如:甲苯、苯、二甲苯等)、饱和烃(例如:环己烷、己烷等)、醚(例如:四氢呋喃、二乙醚、二噁烷等)和它们的混合溶剂等。
[0153]
可以使用的碱包括:例如金属氢氧化物(例如:氢氧化钠、氢氧化钾等)、金属氢化物(例如:氢化钠、氢化锂等)、金属碳酸盐(例如:碳酸钠、碳酸钾、碳酸铯等)等,它们相对于化合物(I′-2)可以使用1当量或以上,优选1-5当量的量。
[0154]
反应温度可以为0℃-150℃,优选为40℃-120℃。尽管反应时间取决于所使用的化合物,但其可以为10分钟-48小时。
[0155]
根据一般制备方法3,制备了下述化合物。
实施例20
3-叔丁基-5-[4-(3-叔丁氧基羰基氨基-5-异噁唑基)苯基]-4-(2-甲氧基苯基)-4,5-二氢-1H-吡咯并[3,4-c]吡唑-6-酮的制备
[化学式56]
在冰冷条件下,向3-叔丁基-5-[4-(3-羧基-5-异噁唑基)苯基]-4-(2-甲氧基苯基)-4,5-二氢-1H-吡咯并[3,4-c]吡唑-6-酮(0.948g,2.0mmol)、三乙胺(0.33mL,2.4mmol)和DMF(15mL)的混合液中添加二苯基磷酰基叠氮(0.52mL,2.4mmol),并在60℃下搅拌2小时。然后添加叔丁醇(15mL)和分子筛粉末4A(2g),并在90℃下搅拌该混合物3小时。通过过滤除去不溶物,对该混合物添加水并用乙酸乙酯萃取该混合物。然后用氯化铵溶液和饱和盐水洗涤有机层,以无水硫酸钠干燥,并在减压下浓缩。将残渣自二氯甲烷结晶,滤取析出的结晶以提供为无色晶体的3-叔丁基-5-[4-(3-叔丁氧基羰基氨基-5-异噁唑基)苯基]-4-(2-甲氧基苯基)-4,5-二氢-1H-吡咯并[3,4-c]吡唑-6-酮(0.566g,52%)。
1H-NMR(δppm TMS/DMSO-d6)1.05(9H,s),1.47(9H,s),3.95(3H,s),6.77-6.80(3H,m),7.00-7.11(2H,m),7.19(1H,m),7.72(2H,d,J=8.6),7.77(2H,d,J=8.6),10.34(1H,s),13.24(1H,brs)。
[0156]
实施例21
3-叔丁基-5-[4-(3-氨基-5-异噁唑基)苯基]-4-(2-甲氧基苯基)-4,5-二氢-1H-吡咯并[3,4-c]吡唑-6-酮的制备
[化学式57]
向3-叔丁基-5-[4-(3-叔丁氧基羰基氨基-5-异噁唑基)苯基]-4-(2-甲氧基苯基)-4,5-二氢-1H-吡咯并[3,4-c]吡唑-6-酮(0.036g,0.7mmol)和甲醇(2mL)的混合液中添加浓盐酸(0.07mL),并在60℃下搅拌该混合物2小时。通过过滤收集沉淀,并进行重结晶(甲醇/二氯甲烷)以提供为浅黄色晶体的3-叔丁基-5-[4-(3-氨基-5-异噁唑基)苯基]-4-(2-甲氧基苯基)-4,5-二氢-1H-吡咯并[3,4-c]吡唑-6-酮(0.02g,68%)。
1H-NMR(δppm TMS/DMSO-d6)1.05(9H,s),3.38(1H,s),3.94(2H,s),5.60(2H,s),6.21(1H,s),6.44(0.3H,s),6.65-6.94(2.7H,m),7.04(1H,d,J=8.1),7.19(1H,t,J=7.6),7.67(4H,s),13.11(0.2H,brs),13.37(0.7H,brs),13.56(0.1H,brs)。
[0157]
实施例22
4-(1,2-二氧代丙基)-3-羟基-1-(4-异噁唑-3-基苯基)-5-(2-甲氧基苯基)-1,5-二氢吡咯-2-酮的制备
[化学式58]
向甲基二甲氧基(甲基)乙酰基丙酮酸钠(0.24g,1mmol)、4-异噁唑-3-基苯胺(0.16g,1mmol)和乙酸(2mL)的混合液中添加2-甲氧基苯甲醛(0.14g,1mmol),并在r.t.下将该混合物搅拌过夜。然后添加水,并通过过滤收集沉淀并进行重结晶(二氯甲烷/乙醚(ether))以提供为浅黄色晶体的4-(2,2-二甲氧基丙酰基)-3-羟基-1-(4-异噁唑-3-基苯基)-5-(2-甲氧基苯基)-1,5-二氢吡咯-2-酮(0.22g,47%)。
向4-(2,2-二甲氧基丙酰基)-3-羟基-1-(4-异噁唑-3-基苯基)-5-(2-甲氧基苯基)-1,5-二氢吡咯-2-酮(0.08g,0.17mmol)中添加乙酸(0.1mL)和水(0.9mL)。在95℃下搅拌该混合物15分钟,然后添加水,用乙酸乙酯萃取该混合物。以无水硫酸钠干燥有机层并在减压下浓缩。将残渣自二氯甲烷和乙醚结晶,滤取析出的结晶以提供为黄色晶体的4-(1,2-二氧代丙基)-3-羟基-1-(4-异噁唑-3-基苯基)-5-(2-甲氧基苯基)-1,5-二氢吡咯-2-酮(0.05g,70%)。
1H-NMR(δppm TMS/DMSO-d6)2.24(3H,s),3.80(3H,s),6.38(1H,s),6.82(1H,t,J=7.3),6.93(1H,d,J=7.3),7.08(1H,d,J=1.6),7.13-7.18(2H,m),7.70-7.84(4H,m),8.96(1H,d,J=1.6)。
[0158]
根据上述合成路径、一般制备方法和实施例的方法制备了下述化合物,其结构和性质示于以下。
在上述表中,
[化学式59]
[0339]
试验例
使用在C6BU-1细胞中引入了人P2X3受体基因(GenBank登录号Y07683)的稳定表达的细胞系。将该细胞以8000个细胞/孔的浓度接种于96孔微量滴定板中,并在37℃、5%二氧化碳气氛下,于培养基(8.3%胎牛血清、8.3%马血清、含1%抗生素和抗真菌剂混合溶液的DMEM)中培养1天。将所述培养基替换为含有4μM的Fluo-3-AM的添加液(20mM HEPES、137mM NaCl、2.7mM KCl、0.9mM MgCl2、5.0mMCaCl2、5.6mM D-葡萄糖、2.5mM丙磺舒、10%BSA、0.08%PluronicF-127、pH 7.5),并在37℃、5%二氧化碳气氛下孵育1小时。用洗涤缓冲液(20mM HEPES、137mM NaCl、2.7mM KCl、0.9mM MgCl2、5.0mM CaCl2、5.6mM D-葡萄糖、2.5mM丙磺舒、pH 7.5)洗涤所述板,并各孔添加40μL的该缓冲液。将所述板置于高通量筛选系统FDSS3000(Hamamatsu Photonics K.K.)。通过FDSS 3000开始荧光强度的测量,用稀释缓冲液(20mM HEPES、137mM NaCl、2.7mM KCl、0.9mMMgCl2、5.0mM CaCl2、5.6mM D-葡萄糖、2.5mM丙磺舒、0.1%Pluronic F-127,pH 7.5)稀释而制备的含有不同浓度检测化合物的DMSO溶液40μL经由FDSS 3000中内置的自动分配器分配至各孔。5分钟后,用所述稀释缓冲液稀释而制备的40nM ATP溶液50μL经由所述内置自动分配器分配,并继续该荧光强度的测量3分钟。对于各孔,比最大荧光强度被计算为ATP溶液添加后的荧光强度的最大值相对于测量开始时的荧光强度的比率。在假定不含检测化合物时的比最大荧光强度为0%抑制、且代替ATP溶液而添加了稀释缓冲液时的比最大荧光强度为100%抑制的条件下,算出了50%抑制浓度(IC50),以评价所述检测化合物的抑制活性。FDSS软设备(Hamamatsu Photonics K.K.)被用于所述比最大荧光强度的计算。IC50使用MicrosoftTM ExcelTM(MicrosoftCorporation)和XLfitTM(ID Business Solutions Ltd.)而计算。
[0340]
本发明的化合物的试验结果示于下表。
[表189]
化合物编号 | P2X3IC50(μM) |
I-1 | 0.01 |
I-2 | 0.01 |
I-4 | 0.02 |
I-6 | 0.03 |
I-20 | 0.14 |
I-21 | 0.16 |
I-24 | 0.18 |
I-25 | 0.18 |
I-28 | 0.26 |
I-36 | 0.38 |
I-44 | 0.56 |
I-45 | 0.58 |
I-48 | 0.97 |
I-49 | 1.02 |
I-52 | 1.27 |
I-53 | 1.28 |
I-57 | 1.53 |
I-62 | 1.96 |
I-66 | 3.46 |
I-69 | 3.78 |
I-72 | 4.79 |
I-74 | 5.92 |
I-76 | 6.48 |
I-77 | 8.01 |
I-79 | 8.95 |
I-88 | 15.43 |
I-95 | 0.56 |
I-96 | 0.92 |
I-118 | 17.80 |
I-122 | 19.30 |
I-124 | 22.00 |
I-251 | 1.40 |
I-260 | 5.63 |
I-273 | 2.20 |
I-278 | 1.40 |
[表190]
化合物编号 | P2X3IC50(μM) |
II-5 | 1.37 |
II-9 | 0.86 |
II-13 | 0.57 |
II-14 | 0.38 |
II-16 | 1.506 |
II-17 | 0.305 |
II-22 | 2.31 |
II-29 | 0.59 |
II-30 | 0.69 |
II-40 | 0.37 |
II-41 | 0.17 |
II-45 | 1.07 |
II-57 | 1.68 |
II-64 | 1.31 |
II-72 | 0.66 |
II-75 | 0.37 |
II-85 | 2.52 |
II-87 | 1.32 |
II-95 | 0.71 |
II-98 | 0.07 |
II-106 | 2.08 |
II-123 | 2.09 |
II-129 | 0.74 |
II-130 | 0.13 |
II-171 | 0.95 |
II-172 | 2.00 |
II-181 | 0.33 |
II-183 | 0.032 |
II-193 | 2.27 |
II-201 | 0.01 |
II-202 | 1.624 |
II-217 | 1.87 |
如所示,本发明的化合物显示对P2X3受体的抑制活性。此外,由于本发明的化合物对P2X3亚型有效,因而该化合物对包含P2X2亚型的P2X2/3受体同样也具有抑制活性。
工业实用性
[0341]
本发明的化合物对P2X3和/或P2X2/3受体具有拮抗作用,因而有用于与P2X3和/或P2X2/3受体有关的疾病比如慢性疼痛,膀胱过度活动症等的治疗。
Claims (21)
1.P2X3和/或P2X2/3受体拮抗物,其包含式(I)的化合物或其可药用的盐或溶剂合物,所述式(I)为:
[化学式1]
其中
Z1为任选地被保护的羟基,任选地被保护的羟氨基或任选地被取代的氨基:
Z2为=O或=N-E,其中E为氢、羟基、任选地被取代的低级烷基、任选地被取代的低级烷氧基或任选地被取代的氨基,或者
[化学式2]
其中R4和R5独立地为氢或低级烷基,R6为氢、任选地被取代的低级烷基或酰基、r为0-2的整数;
Ra和Rb独立地为氢或低级烷基;
q为0-4的整数;
A为环烷基、环烯基、芳基或杂环基;
各R1独立地为卤素、羟基、任选地被取代的低级烷基、任选地被取代的低级链烯基、任选地被取代的低级炔基、任选地被取代的低级烷氧基、任选地被取代的低级烷硫基、任选地被取代的酰基、羧基、任选地被取代的低级烷氧基羰基、任选地被取代的氨甲酰基、任选地被取代的低级烷基氨甲酰基、任选地被取代的氨基、任选地被取代的氨磺酰基、氰基、硝基、任选地被取代的环烷基、任选地被取代的环烯基、任选地被取代的芳基或任选地被取代的杂环基;
n为0-3的整数,
前提是:
[化学式3]
R2为任选地被取代的烷基、任选地被取代的低级烷氧基、任选地被取代的低级烷基氨甲酰基、任选地被取代的环烷基、任选地被取代的环烯基、任选地被取代的芳基或任选地被取代的杂环基;
R3为氢,任选地被取代的烷基、任选地被取代的环烷基、任选地被取代的环烯基、任选地被取代的芳基或任选地被取代的杂环基。
2.根据权利要求1所述的P2X3和/或P2X2/3受体拮抗物,其中Z1为羟基且Z2为=O。
3.根据权利要求1所述的P2X3和/或P2X2/3受体拮抗物,其中r为0。
4.根据权利要求1-3中任一项所述的P2X3和/或P2X2/3受体拮抗物,其中A为苯基、吡啶基或噻唑基。
5.根据权利要求1-4中任一项所述的P2X3和/或P2X2/3受体拮抗物,其中R1为任选地被取代的低级烷氧基羰基或任选地被取代的杂环基。
6.根据权利要求1-5中任一项的P2X3和/或P2X2/3受体拮抗物,其中R2为任选地被取代的低级烷基、任选地被取代的苯基或任选地被取代的吡啶基。
7.根据权利要求1-6中任一项的P2X3和/或P2X2/3受体拮抗物,其中R3为具有3-10个碳原子的烷基、环烷基或任选地被取代的苯基。
8.根据权利要求1-7中任一项的P2X3和/或P2X2/3受体拮抗物,其中q为0。
9.根据权利要求1-7中任一项的P2X3和/或P2X2/3受体拮抗物,其中q为1。
10.式(I′)的化合物或其可药用的盐或溶剂合物:
[化学式4]
其中
Z1为任选地被保护的羟基、任选地被保护的羟氨基或任选地被取代的氨基;Z2为=O或=N-E,其中E为氢、羟基、任选地被取代的低级烷基、任选地被取代的低级烷氧基或任选地被取代的氨基,或者
[化学式5]
其中R4和R5独立地为氢或低级烷基,R6为氢、任选地被取代的低级烷基或酰基、r为0-2的整数;
A和B独立地为环烷基、环烯基、芳基或杂环基;
R1a和R1b独立地为卤素、羟基、任选地被取代的低级烷基、任选地被取代的低级链烯基、任选地被取代的低级炔基、任选地被取代的低级烷氧基、任选地被取代的低级烷硫基、任选地被取代的酰基、羧基、任选地被取代的低级烷氧基羰基、任选地被取代的氨甲酰基、任选地被取代的低级烷基氨甲酰基、任选地被取代的氨基、任选地被取代的氨磺酰基、氰基或硝基;
m和p独立地为0-2的整数;
R2为任选地被取代的烷基、任选地被取代的低级烷氧基、任选地被取代的低级烷基氨甲酰基、任选地被取代的环烷基、任选地被取代的环烯基、任选地被取代的芳基或任选地被取代的杂环基;
R3为氢,任选地被取代的低级烷基、任选地被取代的环烷基、任选地被取代的环烯基、任选地被取代的芳基或任选地被取代的杂环基;
前提是A为吡唑啉酮且B为苯基的化合物除外。
11.根据权利要求10的化合物或可药用的盐或其溶剂合物,其中Z1为任选地被保护的羟基;Z2为=O;R2为任选地被取代的烷基、任选地被取代的低级烷氧基、任选地被取代的环烷基、任选地被取代的环烯基、任选地被取代的芳基或任选地被取代的杂环基。
12.根据权利要求10所述的化合物或可药用的盐或其溶剂合物,其中r为0,R2为任选地被取代的烷基、任选地被取代的低级烷氧基、任选地被取代的环烷基、任选地被取代的环烯基、任选地被取代的芳基或任选地被取代的杂环基。
13.根据权利要求9-12中任一项所述的化合物或其可药用的盐或溶剂合物,其中A为苯基、吡啶基或噻唑基。
14.式(I″)的化合物或可药用的盐或其溶剂合物:
[化学式6]
其中
Z1为任选地被保护的羟基、任选地被保护的羟氨基或任选地被取代的氨基;Z2为=O或=N-E,其中E为氢、羟基、任选地被取代的低级烷基、任选地被取代的低级烷氧基或任选地被取代的氨基,或
[化学式7]
其中R4和R5独立地为氢或低级烷基,R6为氢、任选地被取代的低级烷基或酰基、r为0-2的整数;
A为环烷基、环烯基、芳基或杂环基;
各R1a独立地为卤素、羟基、任选地被取代的低级烷基、任选地被取代的低级烷氧基、任选地被取代的低级烷硫基、任选地被取代的酰基、羧基、任选地被取代的低级烷氧基羰基、任选地被取代的氨甲酰基、任选地被取代的低级烷基氨甲酰基、任选地被取代的氨基、任选地被取代的氨磺酰基、氰基或硝基;
m为0-2的整数;
R1c和R1d独立地为氢或任选地被取代的低级烷基;
R2为任选地被取代的烷基、任选地被取代的低级烷氧基、任选地被取代的低级烷基氨甲酰基、任选地被取代的环烷基、任选地被取代的环烯基、任选地被取代的芳基或任选地被取代的杂环基;
R3为氢,任选地被取代的低级烷基、任选地被取代的环烷基、任选地被取代的环烯基、任选地被取代的芳基或任选地被取代的杂环基。
15.根据权利要求14的化合物或其可药用的盐或溶剂合物,其中Z1为任选地被保护的羟基;Z2为=O;R2为任选地被取代的烷基、任选地被取代的低级烷氧基、任选地被取代的环烷基、任选地被取代的环烯基、任选地被取代的芳基或任选地被取代的杂环基。
16.根据权利要求14所述的化合物或其可药用的盐或溶剂合物,其中r为0;R2为任选地被取代的烷基、任选地被取代的低级烷氧基、任选地被取代的环烷基、任选地被取代的环烯基、任选地被取代的芳基或任选地被取代的杂环基。
17.根据权利要求14-16中任一项所述的化合物或其可药用的盐或溶剂合物,其中A为苯基、吡啶基或噻唑基。
18.药物组合物,其包含根据权利要求10-17中任一项所述的化合物或其可药用的盐或溶剂合物。
19.P2X3和/或P2X2/3受体拮抗物,其包含根据权利要求10-17中任一项所述的化合物或其可药用的盐或溶剂合物。
20.根据权利要求10-17中任一项所述的化合物或其可药用的盐或溶剂合物的用途,其用于与P2X3和/或P2X2/3受体有关的疾病的治疗和/或预防。
21.与P2X3和/或P2X2/3受体有关的疾病的治疗和/或预防用方法,其包括施用根据权利要求10-17中任一项所述的化合物或其可药用的盐或溶剂合物。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP091624/2007 | 2007-03-30 | ||
JP2007091624 | 2007-03-30 | ||
PCT/JP2008/056107 WO2008120725A1 (ja) | 2007-03-30 | 2008-03-28 | 新規ピロリノン誘導体およびそれを含有する医薬組成物 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN101679246A true CN101679246A (zh) | 2010-03-24 |
Family
ID=39808305
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN200880017760A Pending CN101679246A (zh) | 2007-03-30 | 2008-03-28 | 新型吡咯啉酮衍生物以及包含其的药物组合物 |
Country Status (8)
Country | Link |
---|---|
US (2) | US8101644B2 (zh) |
EP (1) | EP2143713A4 (zh) |
JP (1) | JP5624762B2 (zh) |
KR (1) | KR20100016076A (zh) |
CN (1) | CN101679246A (zh) |
CA (1) | CA2682473A1 (zh) |
TW (1) | TW200843739A (zh) |
WO (1) | WO2008120725A1 (zh) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103819476A (zh) * | 2013-03-05 | 2014-05-28 | 中国人民解放军第二军医大学 | 吡咯酮并吡唑类化合物及其作为药物的用途 |
CN104447733A (zh) * | 2015-01-05 | 2015-03-25 | 中国药科大学 | 1-苄基-2-吡咯啉酮-4-酰胺类化合物及其制备方法与应用 |
CN111138289A (zh) * | 2020-02-27 | 2020-05-12 | 奥锐特药业(天津)有限公司 | 一种化合物及使用该化合物合成5-乙酰基-1h-吡唑-3-羧酸的工艺 |
CN112142742A (zh) * | 2019-06-26 | 2020-12-29 | 香港理工大学深圳研究院 | Ctcf转录因子抑制剂及其应用 |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008055945A1 (en) * | 2006-11-09 | 2008-05-15 | Probiodrug Ag | 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases |
KR20100016076A (ko) * | 2007-03-30 | 2010-02-12 | 시오노기 앤드 컴파니, 리미티드 | 신규 피롤리논 유도체 및 그것을 함유하는 의약 조성물 |
FR2929851B1 (fr) | 2008-04-09 | 2012-11-30 | Centre Nat Rech Scient | Molecules inhibant une voie metabolique impliquant la proteine tyrosine kinase syk et procede d'identification de ces molecules |
TW201016702A (en) * | 2008-09-25 | 2010-05-01 | Shionogi & Co | Novel pyrrolinone derivative and pharmaceutical composition comprising the same |
CA2767474A1 (en) * | 2009-07-10 | 2011-01-13 | Vivalis | Substituted pyrrolidinone as inhibitors of hepatitis c ns5b polymerase, the pharmaceutical composition thereof and their therapeutic use |
CA2767467A1 (en) * | 2009-07-10 | 2011-01-13 | Vivalis | 1-(6 members azo-heterocyclic)-pyrrolin-2-one compounds as inhibitors of hepatitis c ns5b polymerase, the pharmaceutical composition thereof and their therapeutic use |
US8440693B2 (en) | 2009-12-22 | 2013-05-14 | Novartis Ag | Substituted isoquinolinones and quinazolinones |
JP6075621B2 (ja) * | 2010-08-10 | 2017-02-08 | 塩野義製薬株式会社 | 新規複素環誘導体およびそれらを含有する医薬組成物 |
GB201016880D0 (en) * | 2010-10-07 | 2010-11-17 | Riotech Pharmaceuticals Ltd | Phosphodiesterase inhibitors |
JP5992054B2 (ja) * | 2011-11-29 | 2016-09-14 | ノバルティス アーゲー | ピラゾロピロリジン化合物 |
JO3357B1 (ar) | 2012-01-26 | 2019-03-13 | Novartis Ag | مركبات إيميدازوبيروليدينون |
JP6124351B2 (ja) * | 2012-02-09 | 2017-05-10 | 塩野義製薬株式会社 | 複素環および炭素環誘導体 |
JP6171003B2 (ja) | 2012-05-24 | 2017-07-26 | ノバルティス アーゲー | ピロロピロリジノン化合物 |
US9737522B2 (en) | 2012-08-09 | 2017-08-22 | Emory University | NMDA receptor modulators and uses related thereto |
WO2014115077A1 (en) | 2013-01-22 | 2014-07-31 | Novartis Ag | Substituted purinone compounds |
US9556180B2 (en) | 2013-01-22 | 2017-01-31 | Novartis Ag | Pyrazolo[3,4-d]pyrimidinone compounds as inhibitors of the P53/MDM2 interaction |
MX2015016344A (es) | 2013-05-27 | 2016-03-01 | Novartis Ag | Derivados de imidazo-pirrolidinona y su uso en el tratamiento de enfermedades. |
US8975417B2 (en) | 2013-05-27 | 2015-03-10 | Novartis Ag | Pyrazolopyrrolidine derivatives and their use in the treatment of disease |
MX2015016425A (es) | 2013-05-28 | 2016-03-03 | Novartis Ag | Derivados de pirazolo-pirrolidin-4-ona y su uso en el tratamiento de enfermedades. |
EA028175B1 (ru) * | 2013-05-28 | 2017-10-31 | Новартис Аг | Производные пиразолопирролидин-4-она в качестве ингибиторов вет и их применение при лечении заболевания |
WO2015004610A1 (en) * | 2013-07-11 | 2015-01-15 | Adamed Sp. Z O.O. | 1,5-dihydropyrrol-2-one derivatives as inhibitors of p53-mdm2/mdm4 protein-protein interaction |
EA029269B1 (ru) | 2013-11-21 | 2018-02-28 | Новартис Аг | Производные пирролопирролона и их применение для лечения заболеваний |
EP3936192A4 (en) | 2019-03-06 | 2022-11-16 | Daiichi Sankyo Company, Limited | PYRROLOPYRAZOL DERIVATIVES |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2097038A1 (en) | 1970-07-29 | 1972-03-03 | Bellon Labor Sa Roger | 1-(substd phenyl)-2-oxo-4-piperazinocarbonyl pyrrolidines - analgesic |
US5508300A (en) * | 1994-01-14 | 1996-04-16 | Pfizer Inc. | Dihydro pyrazolopyrroles, compositions and use |
RU2067575C1 (ru) | 1994-07-27 | 1996-10-10 | Пермский фармацевтический институт | 4-ацетил-5-п-иодфенил-1-карбоксиметил-3-гидрокси-2,5-дигидропиррол-2-он, проявляющий анальгетическую активность |
ATE304523T1 (de) | 2001-05-18 | 2005-09-15 | Abbott Lab | Trisubstituierte-n-((1s)-1,2,3,4-tetrahydro-1- naphthalenyl) benzamide welche p2x3 und p2x2/3 enthaltende rezeptoren inhibieren |
EP1434577A1 (en) * | 2001-10-03 | 2004-07-07 | Ucb, S.A. | Pyrrolidinone derivatives |
CN1930135B (zh) | 2004-03-05 | 2011-12-28 | 弗·哈夫曼-拉罗切有限公司 | 作为p2x3和p2x2/3拮抗剂的二氨基嘧啶 |
NZ554491A (en) | 2004-10-12 | 2009-07-31 | Decode Genetics Ehf | Sulfonamide peri-substituted bicyclics for occlusive artery disease |
JP4987871B2 (ja) | 2005-08-15 | 2012-07-25 | エフ.ホフマン−ラ ロシュ アーゲー | P2x3アンタゴニストとしてのピペリジン及びピペラジン誘導体 |
ES2439454T3 (es) | 2005-09-01 | 2014-01-23 | F. Hoffmann-La Roche Ag | Diaminopirimidinas como moduladores de P2X3 y P2X2/3 |
JP4850911B2 (ja) | 2005-09-01 | 2012-01-11 | エフ.ホフマン−ラ ロシュ アーゲー | P2x3およびp2x2/3モジュレーターとしてのジアミノピリミジン |
BRPI0615613A2 (pt) | 2005-09-01 | 2009-05-19 | Hoffmann La Roche | diaminopirimidinas como moduladores de p2x3 e p3x2/3 |
JP4850913B2 (ja) | 2005-09-01 | 2012-01-11 | エフ.ホフマン−ラ ロシュ アーゲー | P2x3及びp2x2/3調節因子としてのジアミノピリジン |
DE102006025318A1 (de) * | 2006-05-31 | 2007-12-06 | Bayer Healthcare Ag | Dihydro-pyrrolopyridin-, Dihydro-pyrrolopyridazin- und Dihydro-pyrrolopyrimidin-Derivate und ihre Verwendung |
KR20100016076A (ko) * | 2007-03-30 | 2010-02-12 | 시오노기 앤드 컴파니, 리미티드 | 신규 피롤리논 유도체 및 그것을 함유하는 의약 조성물 |
TW201016702A (en) * | 2008-09-25 | 2010-05-01 | Shionogi & Co | Novel pyrrolinone derivative and pharmaceutical composition comprising the same |
-
2008
- 2008-03-28 KR KR1020097022735A patent/KR20100016076A/ko not_active Application Discontinuation
- 2008-03-28 WO PCT/JP2008/056107 patent/WO2008120725A1/ja active Application Filing
- 2008-03-28 TW TW097111332A patent/TW200843739A/zh unknown
- 2008-03-28 CA CA002682473A patent/CA2682473A1/en not_active Abandoned
- 2008-03-28 EP EP08739225A patent/EP2143713A4/en not_active Withdrawn
- 2008-03-28 US US12/450,548 patent/US8101644B2/en not_active Expired - Fee Related
- 2008-03-28 JP JP2009507522A patent/JP5624762B2/ja not_active Expired - Fee Related
- 2008-03-28 CN CN200880017760A patent/CN101679246A/zh active Pending
-
2011
- 2011-09-23 US US13/242,518 patent/US8497263B2/en not_active Expired - Fee Related
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103819476A (zh) * | 2013-03-05 | 2014-05-28 | 中国人民解放军第二军医大学 | 吡咯酮并吡唑类化合物及其作为药物的用途 |
CN103819476B (zh) * | 2013-03-05 | 2016-08-17 | 中国人民解放军第二军医大学 | 吡咯酮并吡唑类化合物及其作为药物的用途 |
CN104447733A (zh) * | 2015-01-05 | 2015-03-25 | 中国药科大学 | 1-苄基-2-吡咯啉酮-4-酰胺类化合物及其制备方法与应用 |
CN104447733B (zh) * | 2015-01-05 | 2016-08-17 | 中国药科大学 | 1-苄基-2-吡咯啉酮-4-酰胺类化合物及其制备方法与应用 |
CN112142742A (zh) * | 2019-06-26 | 2020-12-29 | 香港理工大学深圳研究院 | Ctcf转录因子抑制剂及其应用 |
CN111138289A (zh) * | 2020-02-27 | 2020-05-12 | 奥锐特药业(天津)有限公司 | 一种化合物及使用该化合物合成5-乙酰基-1h-吡唑-3-羧酸的工艺 |
Also Published As
Publication number | Publication date |
---|---|
JPWO2008120725A1 (ja) | 2010-07-15 |
KR20100016076A (ko) | 2010-02-12 |
US20100210632A1 (en) | 2010-08-19 |
EP2143713A1 (en) | 2010-01-13 |
US8101644B2 (en) | 2012-01-24 |
US8497263B2 (en) | 2013-07-30 |
JP5624762B2 (ja) | 2014-11-12 |
EP2143713A4 (en) | 2011-04-20 |
US20120010199A1 (en) | 2012-01-12 |
CA2682473A1 (en) | 2008-10-09 |
TW200843739A (en) | 2008-11-16 |
WO2008120725A1 (ja) | 2008-10-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN101679246A (zh) | 新型吡咯啉酮衍生物以及包含其的药物组合物 | |
JP5656976B2 (ja) | ピロロトリアジン化合物 | |
EP3233840B1 (en) | Heterocyclic derivatives modulating activity of certain protein kinases | |
CN104870446B (zh) | 取代的嘧啶基和吡啶基吡咯并吡啶酮类、其制备方法及其作为激酶抑制剂的用途 | |
AU2015220560B2 (en) | Pyrazolo[1,5-a]pyrimidine-5,7-diamine compounds as CDK inhibitors and their therapeutic use | |
JP5977779B2 (ja) | 2−(2,4,5−置換−アニリノ)ピリミジン化合物 | |
EP2822656B1 (en) | 3-aryl-5-substituted-isoquinolin-1-one compounds and their therapeutic use | |
ES2821821T3 (es) | Derivados de tetrahidroisoquinolina | |
KR102635954B1 (ko) | 5-[[4-[[모르폴린-2-일]메틸아미노]-5-(트리플루오로메틸)-2-피리딜]아미노]피라진-2-카보니트릴 및 그의 치료적 용도 | |
JP5970003B2 (ja) | アミノピラジン化合物 | |
ES2380054T3 (es) | Derivados de aminoindazol activos como inhibidores de quinasas, procedimientos para su preparación, y composiciones farmacéuticas que los contienen | |
CN105682661A (zh) | 某些化学实体、组合物和方法 | |
WO2017049462A1 (zh) | 一类新型的flt3激酶抑制剂及其用途 | |
CN101827848A (zh) | 作为IGF-1R抑制剂用于治疗癌症的2-[(2-{苯基氨基}-1H-吡咯并[2,3-d]嘧啶-4-基)氨基]苯甲酰胺衍生物 | |
BRPI0610184A2 (pt) | composto, sal farmaceuticamente aceitável de um composto, processo para preparar um composto ou um sal farmaceuticamente aceitável do mesmo, uso de um composto ou um sal farmaceuticamente aceitável do mesmo, métodos para a inibição da atividade de trk, para o tratamento ou profilaxia de cáncer e para a produção de um efeito anti-proliferativo em um animal de sanque quente, e, composição farmacêutica | |
CN111051300B (zh) | 作为组蛋白脱乙酰基酶1和/或2(hdac1-2)的选择性抑制剂的新杂芳基酰胺衍生物 | |
TW201838981A (zh) | 嘧啶基-吡啶氧基-萘基化合物以及治療ire1相關之疾病及病症的方法 | |
KR20100134693A (ko) | 2-아미노퀴나졸린 유도체 | |
CA2922469A1 (en) | 3-aryl-5-substituted-isoquinolin-1-one compounds and their therapeutic use | |
CN101652361A (zh) | 作为τ蛋白激酶1抑制剂的2-取代-6-杂环嘧啶酮衍生物 | |
CN103476776A (zh) | 作为FAK/Pyk2抑制剂的2,4-二氨基-6,7-二氢-5H-吡咯并[2,3]嘧啶衍生物 | |
JP2018522874A (ja) | Zesteホモログ2エンハンサー阻害剤 | |
CN102015650A (zh) | 作为5-ht5a受体拮抗剂的2-氨基喹啉衍生物 | |
CN102656172B (zh) | 8-氧代二氢嘌呤衍生物 | |
JP7051855B2 (ja) | プロテインキナーゼ調節剤 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20100324 |