CN101584647A - 高维生素c含量油包多元醇组合物及其制备方法 - Google Patents
高维生素c含量油包多元醇组合物及其制备方法 Download PDFInfo
- Publication number
- CN101584647A CN101584647A CNA2008101007267A CN200810100726A CN101584647A CN 101584647 A CN101584647 A CN 101584647A CN A2008101007267 A CNA2008101007267 A CN A2008101007267A CN 200810100726 A CN200810100726 A CN 200810100726A CN 101584647 A CN101584647 A CN 101584647A
- Authority
- CN
- China
- Prior art keywords
- vitamin
- mixture
- compositions
- polyol
- polylol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 title claims abstract description 90
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 title claims abstract description 45
- 229930003268 Vitamin C Natural products 0.000 title claims abstract description 45
- 235000019154 vitamin C Nutrition 0.000 title claims abstract description 45
- 239000011718 vitamin C Substances 0.000 title claims abstract description 45
- 238000002360 preparation method Methods 0.000 title claims abstract description 9
- 239000000203 mixture Substances 0.000 title claims description 69
- -1 dimethyl siloxane Chemical class 0.000 claims abstract description 39
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 13
- 239000003381 stabilizer Substances 0.000 claims abstract description 12
- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims abstract description 9
- 239000004698 Polyethylene Substances 0.000 claims abstract description 6
- 229920000573 polyethylene Polymers 0.000 claims abstract description 6
- 229920005862 polyol Polymers 0.000 claims description 37
- 150000003077 polyols Chemical class 0.000 claims description 37
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 29
- 239000003921 oil Substances 0.000 claims description 22
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 12
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 10
- 150000005846 sugar alcohols Polymers 0.000 claims description 10
- 150000001298 alcohols Chemical class 0.000 claims description 8
- 229910002012 Aerosil® Inorganic materials 0.000 claims description 7
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 7
- 238000009835 boiling Methods 0.000 claims description 6
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims description 6
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 6
- 239000004743 Polypropylene Substances 0.000 claims description 5
- 150000002148 esters Chemical class 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 5
- 229920001155 polypropylene Polymers 0.000 claims description 5
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims description 4
- 150000001338 aliphatic hydrocarbons Chemical class 0.000 claims description 4
- 239000000440 bentonite Substances 0.000 claims description 4
- 229910000278 bentonite Inorganic materials 0.000 claims description 4
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 claims description 4
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 4
- 229940081733 cetearyl alcohol Drugs 0.000 claims description 4
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 4
- SHZIWNPUGXLXDT-UHFFFAOYSA-N ethyl hexanoate Chemical compound CCCCCC(=O)OCC SHZIWNPUGXLXDT-UHFFFAOYSA-N 0.000 claims description 4
- 239000000194 fatty acid Substances 0.000 claims description 4
- 229930195729 fatty acid Natural products 0.000 claims description 4
- 235000011187 glycerol Nutrition 0.000 claims description 4
- BNWJOHGLIBDBOB-UHFFFAOYSA-N myristicin Chemical compound COC1=CC(CC=C)=CC2=C1OCO2 BNWJOHGLIBDBOB-UHFFFAOYSA-N 0.000 claims description 4
- OQILCOQZDHPEAZ-UHFFFAOYSA-N octyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OCCCCCCCC OQILCOQZDHPEAZ-UHFFFAOYSA-N 0.000 claims description 4
- 239000007787 solid Substances 0.000 claims description 4
- ULQISTXYYBZJSJ-UHFFFAOYSA-N 12-hydroxyoctadecanoic acid Chemical compound CCCCCCC(O)CCCCCCCCCCC(O)=O ULQISTXYYBZJSJ-UHFFFAOYSA-N 0.000 claims description 3
- XDOFQFKRPWOURC-UHFFFAOYSA-N 16-methylheptadecanoic acid Chemical compound CC(C)CCCCCCCCCCCCCCC(O)=O XDOFQFKRPWOURC-UHFFFAOYSA-N 0.000 claims description 3
- 229930006000 Sucrose Natural products 0.000 claims description 3
- VJZWIFWPGRIJSN-XRHABHTOSA-N dilinoleic acid Chemical class CCCCC\C=C/C\C=C/CCCCCCCC(O)=O.CCCCC\C=C/C\C=C/CCCCCCCC(O)=O VJZWIFWPGRIJSN-XRHABHTOSA-N 0.000 claims description 3
- 238000006471 dimerization reaction Methods 0.000 claims description 3
- 229940116351 sebacate Drugs 0.000 claims description 3
- 239000005720 sucrose Substances 0.000 claims description 3
- 229940058015 1,3-butylene glycol Drugs 0.000 claims description 2
- DURPTKYDGMDSBL-UHFFFAOYSA-N 1-butoxybutane Chemical compound CCCCOCCCC DURPTKYDGMDSBL-UHFFFAOYSA-N 0.000 claims description 2
- ZQCIPRGNRQXXSK-UHFFFAOYSA-N 1-octadecoxypropan-2-ol Chemical compound CCCCCCCCCCCCCCCCCCOCC(C)O ZQCIPRGNRQXXSK-UHFFFAOYSA-N 0.000 claims description 2
- LEACJMVNYZDSKR-UHFFFAOYSA-N 2-octyldodecan-1-ol Chemical compound CCCCCCCCCCC(CO)CCCCCCCC LEACJMVNYZDSKR-UHFFFAOYSA-N 0.000 claims description 2
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 claims description 2
- 239000005711 Benzoic acid Substances 0.000 claims description 2
- 229920002367 Polyisobutene Polymers 0.000 claims description 2
- 235000021355 Stearic acid Nutrition 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims description 2
- 238000013019 agitation Methods 0.000 claims description 2
- BTFJIXJJCSYFAL-UHFFFAOYSA-N arachidyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCO BTFJIXJJCSYFAL-UHFFFAOYSA-N 0.000 claims description 2
- 235000010233 benzoic acid Nutrition 0.000 claims description 2
- 235000019437 butane-1,3-diol Nutrition 0.000 claims description 2
- 229910052799 carbon Inorganic materials 0.000 claims description 2
- 125000004432 carbon atom Chemical group C* 0.000 claims description 2
- 239000004359 castor oil Substances 0.000 claims description 2
- 235000019438 castor oil Nutrition 0.000 claims description 2
- 239000000306 component Substances 0.000 claims description 2
- SASYSVUEVMOWPL-NXVVXOECSA-N decyl oleate Chemical compound CCCCCCCCCCOC(=O)CCCCCCC\C=C/CCCCCCCC SASYSVUEVMOWPL-NXVVXOECSA-N 0.000 claims description 2
- PKPOVTYZGGYDIJ-UHFFFAOYSA-N dioctyl carbonate Chemical compound CCCCCCCCOC(=O)OCCCCCCCC PKPOVTYZGGYDIJ-UHFFFAOYSA-N 0.000 claims description 2
- 239000012530 fluid Substances 0.000 claims description 2
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 2
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 claims description 2
- 238000002169 hydrotherapy Methods 0.000 claims description 2
- XUGNVMKQXJXZCD-UHFFFAOYSA-N isopropyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(C)C XUGNVMKQXJXZCD-UHFFFAOYSA-N 0.000 claims description 2
- 229940078812 myristyl myristate Drugs 0.000 claims description 2
- FBUKVWPVBMHYJY-UHFFFAOYSA-N noncarboxylic acid Natural products CCCCCCCCC(O)=O FBUKVWPVBMHYJY-UHFFFAOYSA-N 0.000 claims description 2
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims description 2
- IIGMITQLXAGZTL-UHFFFAOYSA-N octyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCCCCCCC IIGMITQLXAGZTL-UHFFFAOYSA-N 0.000 claims description 2
- PXDJXZJSCPSGGI-UHFFFAOYSA-N palmityl palmitate Chemical compound CCCCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCCCC PXDJXZJSCPSGGI-UHFFFAOYSA-N 0.000 claims description 2
- 239000002245 particle Substances 0.000 claims description 2
- 238000004917 polyol method Methods 0.000 claims description 2
- 229940096956 ppg-11 stearyl ether Drugs 0.000 claims description 2
- 229940078491 ppg-15 stearyl ether Drugs 0.000 claims description 2
- 235000013772 propylene glycol Nutrition 0.000 claims description 2
- 229920002379 silicone rubber Polymers 0.000 claims description 2
- 239000008117 stearic acid Substances 0.000 claims description 2
- ABTZKZVAJTXGNN-UHFFFAOYSA-N stearyl heptanoate Chemical compound CCCCCCCCCCCCCCCCCCOC(=O)CCCCCC ABTZKZVAJTXGNN-UHFFFAOYSA-N 0.000 claims description 2
- DZKXJUASMGQEMA-UHFFFAOYSA-N tetradecyl tetradecanoate Chemical compound CCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCC DZKXJUASMGQEMA-UHFFFAOYSA-N 0.000 claims description 2
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 claims description 2
- 244000060011 Cocos nucifera Species 0.000 claims 1
- 235000013162 Cocos nucifera Nutrition 0.000 claims 1
- 235000020778 linoleic acid Nutrition 0.000 claims 1
- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 claims 1
- 239000002537 cosmetic Substances 0.000 abstract description 12
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract description 6
- 239000001301 oxygen Substances 0.000 abstract description 6
- 229910052760 oxygen Inorganic materials 0.000 abstract description 6
- 230000003647 oxidation Effects 0.000 abstract description 4
- 238000007254 oxidation reaction Methods 0.000 abstract description 4
- 239000006071 cream Substances 0.000 abstract description 2
- 230000002209 hydrophobic effect Effects 0.000 abstract description 2
- 239000000470 constituent Substances 0.000 abstract 2
- 239000002202 Polyethylene glycol Substances 0.000 abstract 1
- 239000000443 aerosol Substances 0.000 abstract 1
- 230000007850 degeneration Effects 0.000 abstract 1
- 229920001223 polyethylene glycol Polymers 0.000 abstract 1
- 239000003755 preservative agent Substances 0.000 abstract 1
- 230000002335 preservative effect Effects 0.000 abstract 1
- 235000019198 oils Nutrition 0.000 description 15
- 238000012360 testing method Methods 0.000 description 8
- 230000000052 comparative effect Effects 0.000 description 6
- 238000003756 stirring Methods 0.000 description 4
- 230000015556 catabolic process Effects 0.000 description 3
- 230000001590 oxidative effect Effects 0.000 description 3
- 238000004448 titration Methods 0.000 description 3
- JPVYNHNXODAKFH-UHFFFAOYSA-N Cu2+ Chemical compound [Cu+2] JPVYNHNXODAKFH-UHFFFAOYSA-N 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 229910001431 copper ion Inorganic materials 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000004945 emulsification Methods 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- MEJYDZQQVZJMPP-ULAWRXDQSA-N (3s,3ar,6r,6ar)-3,6-dimethoxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan Chemical compound CO[C@H]1CO[C@@H]2[C@H](OC)CO[C@@H]21 MEJYDZQQVZJMPP-ULAWRXDQSA-N 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 238000006555 catalytic reaction Methods 0.000 description 1
- 239000003240 coconut oil Substances 0.000 description 1
- 235000019864 coconut oil Nutrition 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- NFDFQCUYFHCNBW-SCGPFSFSSA-N dienestrol Chemical group C=1C=C(O)C=CC=1\C(=C/C)\C(=C\C)\C1=CC=C(O)C=C1 NFDFQCUYFHCNBW-SCGPFSFSSA-N 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 229910021485 fumed silica Inorganic materials 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 229910001385 heavy metal Inorganic materials 0.000 description 1
- 229940078752 magnesium ascorbyl phosphate Drugs 0.000 description 1
- 239000013521 mastic Substances 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- HTJNEBVCZXHBNJ-XCTPRCOBSA-H trimagnesium;(2r)-2-[(1s)-1,2-dihydroxyethyl]-3,4-dihydroxy-2h-furan-5-one;diphosphate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.OC[C@H](O)[C@H]1OC(=O)C(O)=C1O HTJNEBVCZXHBNJ-XCTPRCOBSA-H 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
- A61K8/064—Water-in-oil emulsions, e.g. Water-in-silicone emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/30—Characterized by the absence of a particular group of ingredients
- A61K2800/31—Anhydrous
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Birds (AREA)
- Dispersion Chemistry (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nutrition Science (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (10)
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2008101007267A CN101584647B (zh) | 2008-05-20 | 2008-05-20 | 高维生素c含量油包多元醇组合物及其制备方法 |
EP09158415A EP2123257A3 (en) | 2008-05-20 | 2009-04-22 | Stable high Vitamin C content polyol-in-oil emulsified system and its preparation |
US12/432,181 US20090292015A1 (en) | 2008-05-20 | 2009-04-29 | Stable high vitamin c content polyol-in-oil emulsified system and its preparation |
JP2009119620A JP2009280578A (ja) | 2008-05-20 | 2009-05-18 | 安定な高ビタミンc含量の油中ポリオール乳化系およびその調製 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2008101007267A CN101584647B (zh) | 2008-05-20 | 2008-05-20 | 高维生素c含量油包多元醇组合物及其制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101584647A true CN101584647A (zh) | 2009-11-25 |
CN101584647B CN101584647B (zh) | 2012-10-31 |
Family
ID=41055191
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2008101007267A Expired - Fee Related CN101584647B (zh) | 2008-05-20 | 2008-05-20 | 高维生素c含量油包多元醇组合物及其制备方法 |
Country Status (4)
Country | Link |
---|---|
US (1) | US20090292015A1 (zh) |
EP (1) | EP2123257A3 (zh) |
JP (1) | JP2009280578A (zh) |
CN (1) | CN101584647B (zh) |
Cited By (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104116647A (zh) * | 2014-08-11 | 2014-10-29 | 上海贝泰妮生物科技有限公司 | 一种高含量维生素ce稳定体系复合制剂及其制备方法 |
CN104207950A (zh) * | 2013-06-05 | 2014-12-17 | 上海家化联合股份有限公司 | 气相二氧化硅在增加头发发量方面的应用 |
CN105434181A (zh) * | 2015-12-30 | 2016-03-30 | 广州市科能化妆品科研有限公司 | 一种双层不含水的护肤组合物及其制备方法 |
CN106860051A (zh) * | 2015-12-11 | 2017-06-20 | 上海家化联合股份有限公司 | 一种包含高含量维生素c的多元醇包油组合物及其制备方法 |
CN107822909A (zh) * | 2017-10-31 | 2018-03-23 | 广州市科能化妆品科研有限公司 | 一种含有白藜芦醇的稳定非水性体系及其制备方法 |
CN108403473A (zh) * | 2017-10-24 | 2018-08-17 | 上海百雀羚日用化学有限公司 | 一种用作化妆品的组合物 |
CN109833238A (zh) * | 2017-11-27 | 2019-06-04 | 重庆戴贺李生物科技有限公司 | 一种化妆品用黑果枸杞活性物的提取方法 |
CN109875911A (zh) * | 2019-01-31 | 2019-06-14 | 张鹭云 | 一种易吸收的无水纳米维生素c面霜及其制备方法 |
CN110314112A (zh) * | 2019-08-13 | 2019-10-11 | 西安博和医疗科技有限公司 | 美白组合物及其制备方法 |
CN110507556A (zh) * | 2019-09-18 | 2019-11-29 | 广东丸美生物技术股份有限公司 | 乳液及其制备方法和应用 |
CN110913830A (zh) * | 2017-03-31 | 2020-03-24 | 欧莱雅 | 对减少皱纹和细纹具有短期和长期益处的组合物 |
CN112120975A (zh) * | 2020-10-23 | 2020-12-25 | 上海新如生物科技有限公司 | 一种高维生素c含量的无水洁面乳及其制备方法 |
CN112587438A (zh) * | 2020-12-25 | 2021-04-02 | 彭氏(惠州)实业发展有限公司 | 一种高维生素c含量化妆品组合物及其制备方法和应用 |
CN114099357A (zh) * | 2021-11-30 | 2022-03-01 | 江苏瑞霆生物科技有限公司 | 一种含羟基酪醇的油包多元醇纳米乳液和制备方法及应用 |
CN114452243A (zh) * | 2022-03-17 | 2022-05-10 | 羽楠(广州)化妆品有限公司 | 一种油包醇体系的维c乳液及其制备方法 |
CN115737461A (zh) * | 2022-12-15 | 2023-03-07 | 诺斯贝尔化妆品股份有限公司 | 一种富含离子的乳霜及其制备方法 |
TWI813460B (zh) * | 2021-09-30 | 2023-08-21 | 日商樂敦製藥股份有限公司 | 含有抗壞血酸以及/或是其鹽之油中水型外用組成物 |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5432504B2 (ja) * | 2008-11-19 | 2014-03-05 | コスメテックスローランド株式会社 | 皮膚外用剤およびその製造方法 |
WO2010068903A2 (en) * | 2008-12-11 | 2010-06-17 | L'oreal S.A. | Volumizing smudge resistant mascara composition |
CN101904802B (zh) * | 2009-06-03 | 2015-03-11 | 赢创德固赛有限公司 | 油包水乳液体系及其制备方法 |
WO2011085013A2 (en) * | 2010-01-05 | 2011-07-14 | Kaplan David L | Vitamin c composition for use in the prevention and treatment of stretch marks, radiation dermatitis, and other skin conditions and methods of using the same |
DE102012002951A1 (de) * | 2012-02-16 | 2013-08-22 | Beiersdorf Ag | Stabile Wasser in Öl Emulsionen mit spreitfähigen Ölen |
DE102012002950A1 (de) * | 2012-02-16 | 2013-08-22 | Beiersdorf Ag | Stabile Wasser in Öl Emulsionen mit HLB-ähnlichen Emulgatoren |
DE102012212548A1 (de) * | 2012-07-18 | 2014-01-23 | Beiersdorf Ag | Neustes kosmetisches Sonnenschutzspray |
EP2970668B1 (en) | 2013-03-15 | 2020-07-01 | Bio-rad Laboratories, Inc. | Silicone surfactants for emulsion assays |
KR101553334B1 (ko) | 2013-11-25 | 2015-09-15 | 박봉준 | 알파 리포산염 수용액의 제조방법 및 이의 용도 |
EP2875803A1 (en) * | 2013-11-26 | 2015-05-27 | OTC GmbH | Polyol-in-oil-emulsions for dermal delivery |
FR3062059B1 (fr) * | 2017-01-26 | 2020-08-28 | Laboratoires M&L | Base de formulation cosmetique concentree description |
WO2020216676A1 (en) * | 2019-04-26 | 2020-10-29 | Clariant International Ltd | Emulsion comprising piroctone olamine |
US20220313588A1 (en) * | 2019-09-11 | 2022-10-06 | Amorepacific Corporation | Additive composition for preventing vitamin c precipitation |
FR3111799B1 (fr) * | 2020-06-30 | 2022-06-24 | Oreal | Composition comprenant une association d’esters de polyglycérol |
TW202224676A (zh) * | 2020-09-01 | 2022-07-01 | 日商樂敦製藥股份有限公司 | 皮膚外用組成物以及對皮膚外用組成物賦予對於含有聚烯烴之樹脂之潤濕性提高作用之方法 |
WO2022204951A1 (en) * | 2021-03-30 | 2022-10-06 | L'oreal | A composition for caring for keratin materials |
KR102473874B1 (ko) * | 2021-06-10 | 2022-12-07 | (주)노디너리 | 비타민 c 안정화를 위한 시스템 및 이를 포함하는 화장료 조성물 |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4983382A (en) | 1987-01-27 | 1991-01-08 | Avon Products, Inc. | Cosmetic preparation incorporating stabilized ascorbic acid |
FR2715844B1 (fr) * | 1994-02-04 | 1996-03-29 | Oreal | Emulsion contenant de l'acide ascorbique stabilisé, procédé de traitement cosmétique la mettant en Óoeuvre, ses utilisations. |
EP0794759A1 (en) | 1994-12-21 | 1997-09-17 | The Procter & Gamble Company | Lipstick overcoat compositions comprising silicone oil and silica |
FR2737122B1 (fr) | 1995-07-25 | 1997-09-12 | Oreal | Composition stable contenant de l'acide ascorbique |
US5833973A (en) | 1996-06-28 | 1998-11-10 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Crosslinked elastomeric silicones in aqueous emulsion cosmetic compositions |
US5853741A (en) * | 1996-06-28 | 1998-12-29 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Vitamin C delivery system |
FR2758719B1 (fr) | 1997-01-24 | 1999-03-05 | Oreal | Emulsion eau-dans-huile, composition comprenant une telle emulsion et utilisation en cosmetique, en pharmacie ou en hygiene |
US20030180333A1 (en) * | 1997-06-27 | 2003-09-25 | Revlon Consumer Products Corporation | Compositions containing stabilized ascorbic acid and related methods |
US5981578A (en) | 1997-09-15 | 1999-11-09 | Alexandrides; Ariadne | Increased solubilization and stable cosmetic preparations of ascorbic acid |
US6020367A (en) | 1997-12-02 | 2000-02-01 | Avon Products, Inc. | Supersaturated ascorbic acid solutions |
FR2783713B1 (fr) | 1998-09-29 | 2002-05-31 | Oreal | Utilisation d'une gomme de silicone pour stabiliser l'acide ascorbique et nouvelles compositions contenant ces composants |
FR2786691B1 (fr) | 1998-12-03 | 2003-07-04 | Oreal | Composition sous forme d'emulsion e/h a forte teneur en cire et ses utilisations dans les domaines cosmetiques et dermatologique |
US6685952B1 (en) | 1999-06-25 | 2004-02-03 | Unilever Home & Personal Care Usa, Division Of Conopco, Inc. | Personal care compositions and methods-high internal phase water-in-volatile silicone oil systems |
JP3869980B2 (ja) * | 1999-09-01 | 2007-01-17 | 株式会社コーセー | 油中多価アルコール型固形化粧料 |
EP1159954A3 (en) | 2000-05-31 | 2003-01-02 | Shiseido Company, Ltd. | Solid water-in-oil type emulsion cosmetic composition |
EP1309306A2 (en) | 2000-08-03 | 2003-05-14 | The Procter & Gamble Company | Water-in-oil emulsion compositions comprising polyalkylene glycol styling agents |
JP2002045772A (ja) * | 2000-08-08 | 2002-02-12 | Tokyo Electron Ltd | 塗布装置及び塗布方法 |
KR20020082499A (ko) * | 2001-03-07 | 2002-10-31 | 바이오스펙트럼 주식회사 | 유중 폴리올 액적형 엘-아스코르빈산 콜로이드 화장료조성물 및 이의 제조방법 |
US7270828B2 (en) * | 2001-06-20 | 2007-09-18 | The Procter & Gamble Company | Personal care composition comprising hydrophobic gel |
EP1397118A1 (en) * | 2001-06-20 | 2004-03-17 | The Procter & Gamble Company | Personal care composition comprising polyol-in-silicone emulsion |
US7858104B2 (en) * | 2002-05-02 | 2010-12-28 | L'oreal S.A. | Water-in-oil emulsion foundation |
ATE310497T1 (de) * | 2002-06-20 | 2005-12-15 | Oreal | Kosmetische und/oder dermatologische verwendung einer zusammensetzung, die mindestens einen oxidationsempfindlichen hydrophilen durch mindestens einem polymer oder copolymer stabilisierten wirkstoff aus maleinsäureanhydrid enthält |
FR2841465B1 (fr) | 2002-06-26 | 2006-01-27 | Oreal | Fond de teint emulsion eau-dans-huile |
EP1643964A1 (en) * | 2003-06-19 | 2006-04-12 | The Procter & Gamble Company | Polyol-in-silicone emulsions |
BRPI0403269A (pt) * | 2004-08-06 | 2006-03-21 | Natura Cosmeticos Sa | emulsão múltipla |
DE102005011785A1 (de) | 2005-03-11 | 2006-09-21 | Goldschmidt Gmbh | Langzeitstabile kosmetische Emulsionen |
EP2000124A1 (en) | 2007-06-08 | 2008-12-10 | Evonik Goldschmidt GmbH | Cosmetic and pharmaceutical oil-in-water emulsions containing an ester quat |
-
2008
- 2008-05-20 CN CN2008101007267A patent/CN101584647B/zh not_active Expired - Fee Related
-
2009
- 2009-04-22 EP EP09158415A patent/EP2123257A3/en not_active Ceased
- 2009-04-29 US US12/432,181 patent/US20090292015A1/en not_active Abandoned
- 2009-05-18 JP JP2009119620A patent/JP2009280578A/ja active Pending
Cited By (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104207950A (zh) * | 2013-06-05 | 2014-12-17 | 上海家化联合股份有限公司 | 气相二氧化硅在增加头发发量方面的应用 |
CN104116647A (zh) * | 2014-08-11 | 2014-10-29 | 上海贝泰妮生物科技有限公司 | 一种高含量维生素ce稳定体系复合制剂及其制备方法 |
CN106860051A (zh) * | 2015-12-11 | 2017-06-20 | 上海家化联合股份有限公司 | 一种包含高含量维生素c的多元醇包油组合物及其制备方法 |
CN105434181B (zh) * | 2015-12-30 | 2019-04-23 | 广州市科能化妆品科研有限公司 | 一种双层不含水的护肤组合物及其制备方法 |
CN105434181A (zh) * | 2015-12-30 | 2016-03-30 | 广州市科能化妆品科研有限公司 | 一种双层不含水的护肤组合物及其制备方法 |
CN110913830A (zh) * | 2017-03-31 | 2020-03-24 | 欧莱雅 | 对减少皱纹和细纹具有短期和长期益处的组合物 |
CN110913830B (zh) * | 2017-03-31 | 2023-02-03 | 欧莱雅 | 对减少皱纹和细纹具有短期和长期益处的组合物 |
CN108403473A (zh) * | 2017-10-24 | 2018-08-17 | 上海百雀羚日用化学有限公司 | 一种用作化妆品的组合物 |
CN108403473B (zh) * | 2017-10-24 | 2021-06-25 | 上海百雀羚生物科技有限公司 | 一种用作化妆品的组合物 |
CN107822909A (zh) * | 2017-10-31 | 2018-03-23 | 广州市科能化妆品科研有限公司 | 一种含有白藜芦醇的稳定非水性体系及其制备方法 |
CN109833238A (zh) * | 2017-11-27 | 2019-06-04 | 重庆戴贺李生物科技有限公司 | 一种化妆品用黑果枸杞活性物的提取方法 |
CN109875911A (zh) * | 2019-01-31 | 2019-06-14 | 张鹭云 | 一种易吸收的无水纳米维生素c面霜及其制备方法 |
CN110314112A (zh) * | 2019-08-13 | 2019-10-11 | 西安博和医疗科技有限公司 | 美白组合物及其制备方法 |
CN110507556A (zh) * | 2019-09-18 | 2019-11-29 | 广东丸美生物技术股份有限公司 | 乳液及其制备方法和应用 |
CN112120975A (zh) * | 2020-10-23 | 2020-12-25 | 上海新如生物科技有限公司 | 一种高维生素c含量的无水洁面乳及其制备方法 |
CN112587438A (zh) * | 2020-12-25 | 2021-04-02 | 彭氏(惠州)实业发展有限公司 | 一种高维生素c含量化妆品组合物及其制备方法和应用 |
TWI813460B (zh) * | 2021-09-30 | 2023-08-21 | 日商樂敦製藥股份有限公司 | 含有抗壞血酸以及/或是其鹽之油中水型外用組成物 |
CN114099357A (zh) * | 2021-11-30 | 2022-03-01 | 江苏瑞霆生物科技有限公司 | 一种含羟基酪醇的油包多元醇纳米乳液和制备方法及应用 |
CN114452243A (zh) * | 2022-03-17 | 2022-05-10 | 羽楠(广州)化妆品有限公司 | 一种油包醇体系的维c乳液及其制备方法 |
CN115737461A (zh) * | 2022-12-15 | 2023-03-07 | 诺斯贝尔化妆品股份有限公司 | 一种富含离子的乳霜及其制备方法 |
Also Published As
Publication number | Publication date |
---|---|
CN101584647B (zh) | 2012-10-31 |
US20090292015A1 (en) | 2009-11-26 |
EP2123257A3 (en) | 2012-01-25 |
EP2123257A2 (en) | 2009-11-25 |
JP2009280578A (ja) | 2009-12-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN101584647B (zh) | 高维生素c含量油包多元醇组合物及其制备方法 | |
TW201028175A (en) | Oil-in-water type cosmetic | |
CN102784070A (zh) | 稳定的含有氢醌的油包多元醇组合物及其制备方法 | |
CN1723872B (zh) | 水包油型乳化组合物 | |
TW201249467A (en) | Transparent or translucent oil-in-water emulsion cosmetic composition | |
US20200030201A1 (en) | Oil-in-water emulsion cosmetic | |
CN111643376A (zh) | 一种纳米乳液组合物及其应用 | |
WO2014010622A1 (ja) | 油中水型乳化化粧料 | |
EP2692333B1 (en) | Water-in-oil emulsified cosmetic | |
CN107875034A (zh) | 一种复合抗氧化自微乳及其制备方法和应用 | |
JP4330511B2 (ja) | 水中油型皮膚外用組成物 | |
Hlaing et al. | Stability and Release Kinetics of Natural Oil Microemulsions Containing Nicotinamide. | |
JP4553607B2 (ja) | 水中油型乳化香料組成物及びその製造方法 | |
KR20130012596A (ko) | 저융점 왁스를 함유한 냉장 보관용 화장료 조성물 | |
JP6003000B2 (ja) | 化粧料及び化粧料の製造方法 | |
JP2002308962A (ja) | 乳化組成物 | |
CN105534735A (zh) | 一种具有水包油包醇结构的固体脂质载体及其制备方法 | |
JP6640556B2 (ja) | 水中油型液体入浴剤及びその製造方法 | |
CN112272551A (zh) | 水包油型乳化组合物及其制造方法 | |
JP2019142826A (ja) | 油中水型乳化化粧料 | |
JP7200472B2 (ja) | 組成物 | |
KR102652016B1 (ko) | 액정 유화 조성물 및 그의 제조방법 | |
WO2022136900A1 (en) | Aqueous emulsion | |
CN114867449A (zh) | 水包油型乳化化妆料 | |
CN117098523A (zh) | 酯组合物 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
ASS | Succession or assignment of patent right |
Owner name: EVONIK DEGUSSA SPECIALTY CHEMICALS (SHANGHAI) CO., Free format text: FORMER OWNER: EVONIK DEGUSSA (CHINA) INVESTMENT CO., LTD. Effective date: 20120914 |
|
C41 | Transfer of patent application or patent right or utility model | ||
COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 201108 MINHANG, SHANGHAI TO: 201507 JINSHAN, SHANGHAI |
|
TA01 | Transfer of patent application right |
Effective date of registration: 20120914 Address after: 201507 No. 68, United Road, Shanghai chemical industry zone Applicant after: Evonik Degussa Specialty Chemicals (Shanghai) Co., Ltd. Address before: 201108 No. 68 East Spring Road, Xhenzhuang Industrial Park, Shanghai Applicant before: Evonik Degussa (China) Co., Ltd. |
|
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
C17 | Cessation of patent right | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20121031 Termination date: 20140520 |