US20030180333A1 - Compositions containing stabilized ascorbic acid and related methods - Google Patents
Compositions containing stabilized ascorbic acid and related methods Download PDFInfo
- Publication number
- US20030180333A1 US20030180333A1 US09/770,753 US77075301A US2003180333A1 US 20030180333 A1 US20030180333 A1 US 20030180333A1 US 77075301 A US77075301 A US 77075301A US 2003180333 A1 US2003180333 A1 US 2003180333A1
- Authority
- US
- United States
- Prior art keywords
- organic solvent
- nonaqueous
- ascorbic acid
- composition
- polar organic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 title claims abstract description 212
- 239000000203 mixture Substances 0.000 title claims abstract description 168
- 229960005070 ascorbic acid Drugs 0.000 title claims abstract description 105
- 235000010323 ascorbic acid Nutrition 0.000 title claims abstract description 104
- 239000011668 ascorbic acid Substances 0.000 title claims abstract description 104
- 238000000034 method Methods 0.000 title claims abstract description 26
- 239000003495 polar organic solvent Substances 0.000 claims abstract description 67
- 239000003960 organic solvent Substances 0.000 claims abstract description 44
- 239000000839 emulsion Substances 0.000 claims abstract description 26
- 125000004432 carbon atom Chemical group C* 0.000 claims description 39
- 239000002904 solvent Substances 0.000 claims description 32
- 229920001296 polysiloxane Polymers 0.000 claims description 31
- KBPLFHHGFOOTCA-UHFFFAOYSA-N 1-Octanol Chemical compound CCCCCCCCO KBPLFHHGFOOTCA-UHFFFAOYSA-N 0.000 claims description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 22
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 20
- 239000000194 fatty acid Substances 0.000 claims description 20
- 229930195729 fatty acid Natural products 0.000 claims description 20
- 150000004665 fatty acids Chemical class 0.000 claims description 18
- 238000005192 partition Methods 0.000 claims description 17
- 229920005862 polyol Polymers 0.000 claims description 13
- 150000003077 polyols Chemical class 0.000 claims description 13
- 239000004166 Lanolin Substances 0.000 claims description 11
- 235000019388 lanolin Nutrition 0.000 claims description 11
- 229940039717 lanolin Drugs 0.000 claims description 11
- 239000002537 cosmetic Substances 0.000 claims description 10
- 150000002170 ethers Chemical class 0.000 claims description 10
- 239000005457 ice water Substances 0.000 claims description 10
- 239000002798 polar solvent Substances 0.000 claims description 9
- 238000001816 cooling Methods 0.000 claims description 8
- 238000010438 heat treatment Methods 0.000 claims description 8
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 8
- 229930195733 hydrocarbon Natural products 0.000 claims description 7
- 150000002430 hydrocarbons Chemical class 0.000 claims description 7
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical class OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 claims description 6
- 150000001298 alcohols Chemical class 0.000 claims description 6
- 150000002191 fatty alcohols Chemical class 0.000 claims description 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 4
- 239000012454 non-polar solvent Substances 0.000 claims description 4
- 150000002194 fatty esters Chemical class 0.000 claims description 3
- 125000005908 glyceryl ester group Chemical group 0.000 claims description 2
- 229930182558 Sterol Natural products 0.000 claims 1
- 150000002009 diols Chemical class 0.000 claims 1
- 238000003303 reheating Methods 0.000 claims 1
- 150000003432 sterols Chemical class 0.000 claims 1
- 235000003702 sterols Nutrition 0.000 claims 1
- -1 glucamine Chemical compound 0.000 description 70
- 150000003254 radicals Chemical class 0.000 description 41
- 125000000217 alkyl group Chemical group 0.000 description 38
- 239000004094 surface-active agent Substances 0.000 description 36
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 27
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- 229920000642 polymer Polymers 0.000 description 18
- 239000003995 emulsifying agent Substances 0.000 description 17
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- 125000005375 organosiloxane group Chemical group 0.000 description 17
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- 150000001875 compounds Chemical class 0.000 description 15
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 14
- 235000011187 glycerol Nutrition 0.000 description 14
- 229910052739 hydrogen Inorganic materials 0.000 description 14
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 13
- 239000001257 hydrogen Chemical group 0.000 description 12
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- 125000003118 aryl group Chemical group 0.000 description 11
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 8
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 8
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- 210000003491 skin Anatomy 0.000 description 8
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- 102000008186 Collagen Human genes 0.000 description 7
- 108010035532 Collagen Proteins 0.000 description 7
- XMSXQFUHVRWGNA-UHFFFAOYSA-N Decamethylcyclopentasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 XMSXQFUHVRWGNA-UHFFFAOYSA-N 0.000 description 7
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- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 6
- 229920006395 saturated elastomer Polymers 0.000 description 6
- RMTFNDVZYPHUEF-XZBKPIIZSA-N 3-O-methyl-D-glucose Chemical compound O=C[C@H](O)[C@@H](OC)[C@H](O)[C@H](O)CO RMTFNDVZYPHUEF-XZBKPIIZSA-N 0.000 description 5
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 5
- 125000001931 aliphatic group Chemical group 0.000 description 5
- 125000000129 anionic group Chemical group 0.000 description 5
- 150000001768 cations Chemical class 0.000 description 5
- 125000004122 cyclic group Chemical group 0.000 description 5
- 239000012530 fluid Substances 0.000 description 5
- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 description 5
- 229940119170 jojoba wax Drugs 0.000 description 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 5
- 239000003755 preservative agent Substances 0.000 description 5
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 5
- 239000000377 silicon dioxide Substances 0.000 description 5
- 229920002050 silicone resin Polymers 0.000 description 5
- 125000004469 siloxy group Chemical group [SiH3]O* 0.000 description 5
- AKEJUJNQAAGONA-UHFFFAOYSA-N sulfur trioxide Inorganic materials O=S(=O)=O AKEJUJNQAAGONA-UHFFFAOYSA-N 0.000 description 5
- UUJLHYCIMQOUKC-UHFFFAOYSA-N trimethyl-[oxo(trimethylsilylperoxy)silyl]peroxysilane Chemical class C[Si](C)(C)OO[Si](=O)OO[Si](C)(C)C UUJLHYCIMQOUKC-UHFFFAOYSA-N 0.000 description 5
- ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical compound NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 description 4
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 4
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 4
- 229910020388 SiO1/2 Inorganic materials 0.000 description 4
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 4
- 125000003545 alkoxy group Chemical group 0.000 description 4
- 125000002947 alkylene group Chemical group 0.000 description 4
- 239000003963 antioxidant agent Substances 0.000 description 4
- 235000006708 antioxidants Nutrition 0.000 description 4
- 235000013871 bee wax Nutrition 0.000 description 4
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- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 4
- 229920006317 cationic polymer Polymers 0.000 description 4
- 239000003093 cationic surfactant Substances 0.000 description 4
- 239000007795 chemical reaction product Substances 0.000 description 4
- 229940096386 coconut alcohol Drugs 0.000 description 4
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 4
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 4
- 239000002480 mineral oil Substances 0.000 description 4
- 235000010446 mineral oil Nutrition 0.000 description 4
- 229920000573 polyethylene Polymers 0.000 description 4
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 4
- 230000005855 radiation Effects 0.000 description 4
- 229940088594 vitamin Drugs 0.000 description 4
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- 125000004178 (C1-C4) alkyl group Chemical group 0.000 description 3
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 3
- 244000060011 Cocos nucifera Species 0.000 description 3
- 235000013162 Cocos nucifera Nutrition 0.000 description 3
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 3
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 3
- CMBYOWLFQAFZCP-UHFFFAOYSA-N Hexyl dodecanoate Chemical compound CCCCCCCCCCCC(=O)OCCCCCC CMBYOWLFQAFZCP-UHFFFAOYSA-N 0.000 description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- 229910019142 PO4 Inorganic materials 0.000 description 3
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- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 3
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- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 3
- UKMSUNONTOPOIO-UHFFFAOYSA-N docosanoic acid Chemical compound CCCCCCCCCCCCCCCCCCCCCC(O)=O UKMSUNONTOPOIO-UHFFFAOYSA-N 0.000 description 3
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- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
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- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 description 1
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- 229940105131 stearamine Drugs 0.000 description 1
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- 125000005480 straight-chain fatty acid group Chemical group 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 150000003900 succinic acid esters Chemical class 0.000 description 1
- 239000001959 sucrose esters of fatty acids Substances 0.000 description 1
- 235000010965 sucrose esters of fatty acids Nutrition 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- DIORMHZUUKOISG-UHFFFAOYSA-N sulfoformic acid Chemical compound OC(=O)S(O)(=O)=O DIORMHZUUKOISG-UHFFFAOYSA-N 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
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- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 description 1
- XOLBLPGZBRYERU-UHFFFAOYSA-N tin dioxide Chemical compound O=[Sn]=O XOLBLPGZBRYERU-UHFFFAOYSA-N 0.000 description 1
- 229910001887 tin oxide Inorganic materials 0.000 description 1
- LLZRNZOLAXHGLL-UHFFFAOYSA-J titanic acid Chemical compound O[Ti](O)(O)O LLZRNZOLAXHGLL-UHFFFAOYSA-J 0.000 description 1
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- ABVVEAHYODGCLZ-UHFFFAOYSA-N tridecan-1-amine Chemical compound CCCCCCCCCCCCCN ABVVEAHYODGCLZ-UHFFFAOYSA-N 0.000 description 1
- 125000002889 tridecyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 229940057400 trihydroxystearin Drugs 0.000 description 1
- 229940081852 trilinolein Drugs 0.000 description 1
- LINXHFKHZLOLEI-UHFFFAOYSA-N trimethyl-[phenyl-bis(trimethylsilyloxy)silyl]oxysilane Chemical compound C[Si](C)(C)O[Si](O[Si](C)(C)C)(O[Si](C)(C)C)C1=CC=CC=C1 LINXHFKHZLOLEI-UHFFFAOYSA-N 0.000 description 1
- GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical compound CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 description 1
- VLPFTAMPNXLGLX-UHFFFAOYSA-N trioctanoin Chemical compound CCCCCCCC(=O)OCC(OC(=O)CCCCCCC)COC(=O)CCCCCCC VLPFTAMPNXLGLX-UHFFFAOYSA-N 0.000 description 1
- PHYFQTYBJUILEZ-IUPFWZBJSA-N triolein Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(OC(=O)CCCCCCC\C=C/CCCCCCCC)COC(=O)CCCCCCC\C=C/CCCCCCCC PHYFQTYBJUILEZ-IUPFWZBJSA-N 0.000 description 1
- 229940117972 triolein Drugs 0.000 description 1
- AAAQKTZKLRYKHR-UHFFFAOYSA-N triphenylmethane Chemical compound C1=CC=CC=C1C(C=1C=CC=CC=1)C1=CC=CC=C1 AAAQKTZKLRYKHR-UHFFFAOYSA-N 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 235000019871 vegetable fat Nutrition 0.000 description 1
- 229920001567 vinyl ester resin Polymers 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 235000019156 vitamin B Nutrition 0.000 description 1
- 239000011720 vitamin B Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 235000019166 vitamin D Nutrition 0.000 description 1
- 239000011710 vitamin D Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 235000019168 vitamin K Nutrition 0.000 description 1
- 239000011712 vitamin K Substances 0.000 description 1
- 229940011671 vitamin b6 Drugs 0.000 description 1
- 235000020234 walnut Nutrition 0.000 description 1
- 229940075420 xanthine Drugs 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229940098697 zinc laurate Drugs 0.000 description 1
- 229940105125 zinc myristate Drugs 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
- GPYYEEJOMCKTPR-UHFFFAOYSA-L zinc;dodecanoate Chemical compound [Zn+2].CCCCCCCCCCCC([O-])=O.CCCCCCCCCCCC([O-])=O GPYYEEJOMCKTPR-UHFFFAOYSA-L 0.000 description 1
- GBFLQPIIIRJQLU-UHFFFAOYSA-L zinc;tetradecanoate Chemical compound [Zn+2].CCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCC([O-])=O GBFLQPIIIRJQLU-UHFFFAOYSA-L 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/30—Characterized by the absence of a particular group of ingredients
- A61K2800/31—Anhydrous
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
Definitions
- the invention pertains to the field of compositions, particularly cosmetic compositions, containing ascorbic acid in bioavailable form.
- Collagen consists of long elastic polypeptide fibers interconnected by bridges which provide the cohesion and stability of connective tissue. This enables collagen to act as an elastic tissue in every direction and retain water. Collagen aging manifests itself as a break in connection between the collagen fibers. Age, severe weather, and pollution accelerate the breaks and slow down renewal of the collagen structure.
- Ascorbic acid or Vitamin C, has many known biological functions.
- the L-ascorbic acid isomer is biologically active and is known to stimulate the synthesis of collagen, act as a free radical scavenger, and minimize lipid peroxidation and other forms of cellular damage associated with aging
- Ascorbic acid is a white, odorless, crystalline solid having the empirical formula C 6 H 8 O 6 , a molecular weight of about 176, and exhibits the following structural formula:
- Ascorbic acid is highly soluble, but extremely unstable, in water and rapidly decomposes to form dehydroascorbic acid. This degradation is even more pronounced in the presence of oxygen. It is known that ascorbic acid is much more stable in nonaqueous polar solvents such as polyols, but unfortnately its solubility is limited in such solvents and it generally is thought to be not possible to obtain stable ascorbic acid solutions of more than several percent by weight concentration. Since the anti-aging effects of ascorbic acid are known to be dose-dependent, it is desirable to make stable cosmetic compositions containing ascorbic acid dispersed in a cosmetically acceptable carrier at a concentration of greater than about 5 weight percent, preferably up to 20 or 30 weight percent.
- European Patent Publication No. 0 729 746 teaches an ascorbic acid delivery system comprised of a two compartment kit.
- a nonaqueous polar solvent such as a polyol.
- an alkaline aqueous solution is used in the second compartment. The contents of the two compartments. The more alkaline aqueous solution increases the pH of the anhydrous ascorbic acid containing solution to provide a composition which does not tingle the skin.
- U.S. Pat. No. 5,350,773 teaches stable liquid products used for liquid human and animal food.
- the compositions are in the form of anhydrous emulsions containing a nonpolar fatty material as the dispersed phase and a polar nonaqueous solvent as the continuous phase.
- Esters of ascorbic acid are used as the emulsifying agent.
- U.S. Pat. No. 5,427,814 teaches a method for protecting a fat against oxidation by mixing ascorbic acid into a polar solvent, and adding the mixture to a heated mixture of tocopherol and lecithin. The polar solvent is then evaporated from the mixture by subjecting the mixture to heat for a period of time.
- U.S. Pat. No. 5,308,621 teaches a method for transdermal administration of ascorbic acid. Fine particulate ascorbic acid is suspended in a pharmaceutically acceptable carrier such as a polyol. The compositions are topically applied and the particulate ascorbic acid dissolves upon contact with skin and is absorbed into the skin.
- European Patent Publication No. 0 755 674 teaches stabilized ascorbic acid compositions containing a water activity value of less than 0.85.
- the compositions contain a minimum level of water, in addition to a polyol and an oil.
- U.S. Pat. No. 5,587,149 teaches ascorbic acid emulsion compositions comprising ascorbic acid solubilized in a polyol as the dispersed phase and oil as the continuous phase.
- An object of the invention is to provide a method for stabilizing ascorbic acid to enable its use in cosmetic products which have anti-aging effects.
- Another object of the invention is to provide a stabilized ascorbic acid composition suitable for use in cosmetics.
- Another object of the invention is to provide a stabilized ascorbic acid composition containing ascorbic acid at significant concentrations.
- Another object of the invention is to provide a stabilized ascorbic acid composition in an anhydrous emulsion form which contains ascorbic acid at significant concentrations.
- the invention comprises a composition in the form of an anhydrous emulsion having as a dispersed phase, ascorbic acid dissolved by means of energy input, in a nonaqueous polar organic solvent, and as the continuous phase a nonaqueous nonpolar organic solvent.
- the invention comprises a composition in the form of an anhydrous emulsion having as the dispersed phase a nonaqueous nonpolar organic solvent, and as the continuous phase ascorbic acid dissolved in a nonaqueous polar organic solvent.
- the invention is also directed to a method for dissolving ascorbic acid in a nonaqueous polar organic solvent comprising the steps of:
- the invention is also directed to a method for making an anhydrous emulsion having as a dispersed phase ascorbic acid dissolved in a nonaqueous polar organic solvent, and as the continuous phase a nonaqueous nonpolar organic solvent, comprising the steps of:
- the invention also comprises a method for making an anhydrous emulsion having as the dispersed phase a nonaqueous nonpolar organic solvent, and as the continuous phase ascorbic acid dissolved in a nonaqueous polar organic solvent, comprising the steps of:
- the invention is directed to cosmetic compositions comprising, by weight of the total composition:
- corbic acid when used in accordance with this invention means L-ascorbic acid, the bioavailable form, and derivatives thereof.
- partition coefficient when used in accordance with the invention means the octanol/water partition coefficient of the solvent as calculated by the ACD/LogP software program marketed by Advanced Chemistry Development, Inc. The software calculates the partition coefficient based upon the molecular structure of the solvent. Actual chemical measurement of partition coefficients may be difficult.
- the partition coefficient is defined as, in the equilibrium distribution of the solvent between two liquid phases, one of which is water and the other of which is octanol, the ratio of the solvent concentration in the octanol phase to the solvent concentration in the water phase.
- polar means, when used to characterize the solvent, that the logarithm of the octanol/water partition coefficient of the solvent as measured by the ACD/LogP software program, is less than or equal to ⁇ 0.2 at room temperature.
- a polar solvent is one which is capable of solubilizing at least 2 weight percent or more of ascorbic acid at room temperature (generally 25° C.)
- nonpolar means, with respect to the solvent, that the logarithm of the octanol/water partition coefficient of the solvent as measured by the ACD/LogP software program, is greater than ⁇ 0.2 at room temperature.
- a nonpolar solvent is one which is capable of solubilizing less than 2 weight percent of ascorbic acid at room temperature.
- anhydrous means that no substantial amount of water is added to the compositions of the invention. Trace amounts of water (for example, supplied as an impurity in the raw materials used to make the compositions of the invention) may still be presents e.g. in an amount less than about 5% by weight of the total composition, preferably less than 1 to 3% by weight of the total composition.
- dissolved or “dissolving” means that the ascorbic acid is essentially solubilized or dissolved in the nonaqueous polar organic solvent, and that the ascorbic acid will not exist to any appreciable degree in the particulate or crystalline form.
- compositions of the invention may be liquid, semi-solid, or solid at room temperature.
- the compositions exist in an anhydrous emulsion form.
- emulsion is generally used in the cosmetic art to mean water-in-oil or oil-in-water emulsions.
- the compositions of the invention are anhydrous emulsions wherein one anhydrous phase (‘the dispersed phase’) is dispersed into another anhydrous phase (“the continuous phase”).
- the dispersed phase is dispersed into another anhydrous phase
- the continuous phase the ascorbic acid dissolved into the nonaqueous polar organic solvent
- the nonaqueous nonpolar organic solvent forms the continuous phase.
- the anhydrous emulsions of the invention contain 1-99%, preferably 20-80%, more preferably 40-60% by weight of the total composition, of a nonaqueous polar organic solvent.
- a nonaqueous polar organic solvent are suitable for use in the dispersed phase of the anhydrous emulsion.
- a solvent, in particular a nonaqueous solvent is considered “polar” in the context of the invention if the logarithm of the partition coefficient of the solvent is less than or equal to ⁇ 0.2 at room temperature. Examples are as follows.
- Polyols are suitable nonaqueous polar organic solvents.
- polyols are defined as compounds which contain three or more hydroxyl groups per molecule.
- suitable polyols include fructose, glucamine, glucose, glucose glutamate, glucuronic acid, glycerin, 1,2,6hexanetriol, hydroxystearyl methylglucanine, inositol, lactose, malitol, mannitol, methyl gluceth-10, methyl gluceth-20, methyl glucose dioleate, methyl glucose sesquicaprylate/sesquicaprate, methyl glucose sesquicocoate, methyl glucose sesquiisostearate, methyl glucose sesquilaurate, methyl glucose sesquistearate, phytantriol, riboflavin, sorbeth-6, sorbeth-20, sorbeth-30, sorbeth-40, sorbitol, sucrose, thioglycerin,
- nonaqueous polar organic solvent are homopolymeric or block copolymeric liquid ethers.
- Polymeric ethers are preferably formed by polymerization of monomeric alkylene oxides, generally ethylene or propylene oxides.
- R is H or C 1-10 straight or branched chain alkyl, and n is 1 to 20.
- polymeric ethers include PEG, PPG, and derivatives thereof.
- polystyrene resin examples include polyoxypropylene polyoxyethylene block copolymers having the general formula:
- x is 1-200
- y is 1-200
- z is 1-200.
- Such compounds are sold under the CTFA name Meroxapol 105, 108, 171, 172, 174, 178, 251, 252, 254, 255, 258, 311, 312, and 314.
- nonaqueous polar organic solvent are mono- and dihydric alcohols of the general formula R(OH) n where n is 1 or 2 and R is a substituted or unsubstituted saturated C 2-10 , preferably C 1-8 alkyl, or a substituted or unsubstituted alicyclic, bicyclic, or aromatic ring, with the substituents selected from halogen, alkoxy, hydroxy, and so on.
- suitable alcohols include monohydric alcohols such as ethanol, isopropanol, hexyldecanol, benzyl alcohol, propyl alcohol, and isopropyl alcohol, as well as dihydric alcohols such as hexylene glycol, diethylene glycol, ethylene glycol, propylene glycol, 1,2-butylene glycol, triethylene glycol, dipropylene glycol, and mixtures thereof.
- monohydric alcohols such as ethanol, isopropanol, hexyldecanol, benzyl alcohol, propyl alcohol, and isopropyl alcohol
- dihydric alcohols such as hexylene glycol, diethylene glycol, ethylene glycol, propylene glycol, 1,2-butylene glycol, triethylene glycol, dipropylene glycol, and mixtures thereof.
- Sorbitan derivatives which are defined as ethers or esters of sorbitan, are also suitable polar solvents.
- suitable sorbitan derivatives are the Polysorbates, which are defined as stearate esters of sorbitol and sorbitan anhydrides, such as Polysorbate 20, 21, 40, 60, 61, 65, 80, 81, and 85.
- fatty esters of hexitol anhydrides derived from sorbitol such as sorbitan trioleate, sorbitan tristearate, sorbitan sesquistearate, sorbitan stearate, sorbitan palmitate, sorbitan oleate, and mixtures thereof.
- the anhydrous emulsions of the invention contain 1-99%, preferably 20-80%, more preferably 4060%, by weight of total composition, of a nonaqueous nonpolar organic solvent as the continuous phase.
- a nonaqueous nonpolar organic solvent as the continuous phase.
- Such solvents are defined as those where the logarithm of the partition coefficient is greater than ⁇ 0.2 at room temperature.
- a variety of nonaqueous nonpolar organic solvents can be used in the compositions of the invention.
- Silicones are suitable nonpolar compounds.
- the silicones may be volatile or non-volatile.
- volatile means that the silicone has a measureable vapor pressure, i.e. a vapor pressure of at least 2 mm. of mercury at 20° C. If volatile, the silicone generally will have a viscosity of 0.5 to 25 centistokes at 25° C.
- Suitable volatile silicones include cyclic silicones, linear silicones, or mixtures thereof. Cyclic silicones (or cyclomethicones) are of the general formula:
- n 3-7, and R 1 and R 2 are each independently H, C 1-8 alkyl, aryl, aralkyl, alkenyl, or a cylic or alicylic ring.
- R 1 and R 2 are each independently H or CH 3 .
- Most preferably R 1 and R 2 are each CH 3 .
- Linear volatile silicones in accordance with the invention have the general formula:
- n 0-7, preferably 0-5.
- Linear and cyclic volatile silicones are available from various commercial sources including Dow Corning Corporation and General Electric.
- the Dow Corning volatile silicones are sold under the tradenames Dow Corning 244, 245, 344, and 200 fluids. These fluids comprise octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, hexamethyldisiloxane, and mixtures thereof.
- the silicone may also be nonvolatile, and in particular water insoluble nonvolatile silicones.
- nonvolatile means that the silicone has a vapor pressure of less than 2 mm. of mercury at 20° C.
- a variety of silicones fit this definition including dimethicone, phenyl trimethicone, diphenyl dimethicone, methicone, hexadecyl methicone, stearoxydimethicone, stearyl dimethicone, cetyl dimethicone, and so on.
- Cyclomethicone is the preferred silicone for use in the compositions of the invention.
- esters are also suitable as the nonaqueous nonpolar organic solvent.
- such esters have the formula RCO—OR wherein each R is independently a C 1-25 straight or branched chain saturated or unsaturated alkyl, alkylcarbonyloxyalkyl, or alkoxycarbonylalkyl, aryl, which may be substituted or unsubstituted with halogen, hydroxyl, alkyl, and the like.
- esters examples include alkyl acetates, alkyl behenates, alkyl lactates, alkyl benzoates, alkyl octanoates, alkyl salicylates, and in particular C 12-15 alkyl benzoate.
- esters include alkyl acetates, alkyl behenates, alkyl lactates, alkyl benzoates, alkyl octanoates, alkyl salicylates, and in particular C 12-15 alkyl benzoate.
- Fats and oils are also suitable as the nonaqueous nonpolar organic solvent.
- these materials are liquids or semi-solids at room temperature. They are generally defined as glyceryl esters of fatty acids (triglycerides), as well as the synthetically prepared esters of glycerin and fatty acids having the following general formula:
- R, R′, and R′′ are each independently fatty acid radicals.
- oils such as apricot kernel oil, avocado oil, canola oil, olive oil, sesame oil, peanut oil, soybean oil, trilinolenin, trilinolein, trioctanoin, tristearin, triolein, sesame oil, rapeseed oil, sunflower seed oil, and so on.
- Fatty acids are also suitable as the nonaqueous nonpolar organic solvent in the compositions of the invention.
- the fatty acids are liquid or semi solid at room temperature.
- Fatty acids are the carboxylic acids obtained by hydrolysis of animal or vegetable fats and oils. Carboxylic acids having alkyl chains shorter than about seven carbon atoms are not generally considered fatty acids.
- Fatty acids have the general structure R—COOH where R is a straight or branched chain saturated or unsaturated C 7-65 alkyl.
- Suitable fatty acids include arachidic acid, arachidonic acid, behenic acid, capric acid, caproic acid, caprylic acid, coconut acid, corn acid, cottonseed acid, hydrogenated coconut acid, hydroxystearic acid, lauric acid, linoleic acid, linolenic acid, linseed acid, myristic acid, oleic acid, palmitic acid, palm kernel acid, soy acid, tallow acid, and the like.
- Fatty alcohols may also be used as the nonaqueous nonpolar organic solvent.
- Fatty alcohols are generally made by reducing the fatty acid —COOH group to the hydroxyl function. They generally have the formula RCH 2 OH.
- fatty alcohols are behenyl alcohol, C 9-11 alcohol, C 12-13 alcohol, C 12-15 alcohol, C 12-16 alcohol, caprylic alcohol, cetearyl alcohol, cetyl alcohol, coconut alcohol, decyl alcohol, lauryl alcohol, myristyl alcohol, oleyl alcohol, and the like.
- Hydrocarbons are also good nonaqueous nonpolar organic solvents in accordance with the invention.
- suitable hydrocarbons include C 7-60 isoparaffins, ethane, heptane, hexane, hydrogenated polyisobutene, isobutane, isododecane, isoeicosane, isohexadecane, isopentane, microcrystalline wax, mineral oil, mineral spirits, paraffin, petrolatum, petroleum distillates, squalene, polyethylene, and mixtures thereof.
- Preferred hydrocarbons are mineral oil and polyethylene.
- nonaqueous nonpolar organic solvent examples include lanolin and derivatives thereof.
- examples of such materials include acetylated hydrogenated lanolin, acetylated lanolin alcohol, laneth, lanolin acid, lanolin oil, lanolin alcohol, lanolin wax, and so on.
- compositions of the invention may also be desired to include certain other ingredients in the anhydrous emulsions of the invention, such as surfactants, waxes, colorants, preservatives, and so on.
- compositions may contain 0.1-15%, preferably 0.5-10%, more preferably 1-8% by weight of the total composition of one or more surfactants.
- surfactant is defined, in accordance with the invention, as a compound having at least one hydrophilic moiety and at least one lipophilic moiety.
- the surfactants may be silicone surfactants (also referred to as organosiloxane emulsifiers) or organic surfactants.
- Suitable silicone surfactants used in the compositions of the invention may be liquid or solid at room temperature and are generally a water-in-oil or oil-in-water type surfactants which are preferably nonionic, having an Hydrophile/Lipophile Balance (HLB) of 2 to 18.
- HLB Hydrophile/Lipophile Balance
- the organosiloxane is a nonionic surfactant having an HLB of 2 to 12, preferably 2 to 10, most preferably 4 to 6.
- the HLB of a nonionic surfactant is the balance between the hydrophilic and lipophilic portions of the surfactant and is calculated according to the following formula:
- M w is the molecular weight of the hydrophilic group portion and M o is the molecular weight of the lipophilic group portion.
- HLB 20(1 ⁇ S/A )
- S is the saponification number of the surfactant and A is the acid number of the surfactant.
- the silicone surfactant or emulsifier used in the compositions of the invention is a polymer containing a polymeric backbone including repeating siloxy units that may have cyclic, linear or branched repeating units, e.g. di(lower)alkylsiloxy units, preferably dimethylsiloxy units.
- the hydrophilic portion of the organosiloxane is generally achieved by substitution onto the polymeric backbone of a radical that confers hydrophilic properties to a portion of the molecule.
- the hydrophilic radical may be substituted on a terminus of the polymeric organosiloxane, or on any one or more repeating units of the polymer.
- the repeating dimethylsiloxy units of modified polydimethylsiloxane emulsifiers are lipophilic in nature due to the methyl groups, and confer lipophilicity to the molecule.
- longer chain alkyl radicals, hydroxy-polypropyleneoxy radicals, or other types of lipophilic radicals may be substituted onto the siloxy backbone to confer further lipophilicity and organocompatibility. If the lipophilic portion of the molecule is due in whole or part to a specific radical, this lipophilic radical may be substituted on a terminus of the organosilicone polymer, or on any one or more repeating units of the polymer.
- the organosiloxane polymer in accordance with the invention should have at least one hydrophilic portion and one lipophilic portion.
- hydrophilic radical means a radical that, when substituted onto the organosiloxane polymer backbone, confers hydrophilic properties to the substituted portion of the polymer.
- radicals that will confer hydrophilicity are hydroxy-polyethyleneoxy, hydroxyl, carboxylates, sulfonates, sulfates, phosphates, or amines.
- lipophilic radical means an organic radical that, when substituted onto the organosiloxane polymer backbone, confers lipophilic properties to the substituted portion of the polymer.
- organic radicals which will conver lipophilicity are C 1-40 straight or branched chain alkyl, fluoro, aryl, aryloxy, C 1-40 hydrocarbyl acyl, hydroxy-polypropyleneoxy, or mixtures thereof.
- the C 1-40 alkyl may be non-interrupted, or interruped by one or more oxygen atoms, a benzene ring, amides, esters, or other functional groups.
- polymeric organosiloxane emulsifier used in the invention may have any of the following general formulas:
- each M is independently a substituted or unsubstituted trimethylsiloxy endcap unit. If substituted, one or more of the hydrogens on the endcap methyl groups are substituted, or one or more methyl groups are substituted with a substituent that is a lipophilic radical, a hydrophilic radical, or mixtures thereof.
- T is a trifunctional siloxy unit having the empirical formula RSiO 15 or RSiO 15 .
- Q is a quadrifunctional siloxy unit having the empirical formula SiO 2
- D, D′, D′′, x, y, and z are as set forth below, with the proviso that the compound contains at least one hydrophilic radical and at least one lipophilic radical.
- emulsifiers used in the compositions of the invention are of the general formula:
- the trimethylsiloxy endcap unit is unsubstituted or mono-substituted, wherein one methyl group is substituted with a lipophilic radical or a hydrophilic radical.
- substituted trimethylsiloxy endcap units include (CH 3 ) 2 HPSiO, (CH 3 ) 2 LPSiO, (CH 3 ) 2 CH 2 HPSiO, (CH 3 ) 2 CH 2 LPSiO, wherein HP is a hydrophilic radical and LP is a lipophilic radical.
- D, D′, and D′′ are difunctional siloxy units substituted with methyl, hydrogen, a lipophilic radical, a hydrophilic radical or mixtures thereof. In this general formula:
- x 0-5000, preferably 1-1000
- y 0-5000, preferably 1-1000, and
- the compound contains at least one lipophilic radical and at least one hydrophilic radical.
- examples of these polymers are disclosed in U.S. Pat. No. 4,698,178, which is hereby incorporated by reference.
- x, y, and z are each independently 0-1000,
- R is methyl or hydrogen
- R′ is a hydrophilic radical or a lipophilic radical, with the proviso that the compound contains at least one hydrophilic radical and at least one lipophilic radical.
- D′ Si [(CH 3 )][(CH 2 ) o —O-PE)]O 2/2
- Typical examples of preferred organosiloxane emulsifiers in accordance with the invention include those set forth below:
- HP is a hydrophilic radical
- x is 0-5000
- y is 0-5000
- z is 0-5000, with the proviso that the organosiloxane contains at least on hydrophilic radical and at least one lipophilic radical.
- LP is a lipophilic radical which is a C 1-40 straight or branched chain alkyl
- HP is a hydrophilic radical containing hydroxy-polyethyleneoxy
- z is at least 1.
- LP is a lipophilic radical which is a C 1-40 straight or branched chain alkyl
- HP is a hydrophilic radical containing hydroxy-polyethyleneoxy
- z is at least 1.
- LP is a lipophilic radical which is a C 1-40 straight or branched chain alkyl
- HP is a hydrophilic radical containing hydroxy-polyethyleneoxy
- z is at least 1.
- PE is (—C 2 H 4 O)a(—C 3 H 6 O) b —H
- Organosiloxane polymers useful in the compositions of the invention are commercially available from Goldschmidt Corporation under the ABIL tradename.
- the preferred polymer is cetyl dimethicone copolyol and has the tradename ABIL WE 09 or ABIL WS 08.
- the cetyl dimethicone copolyol may be used alone or in conjunction with other non-silicone organic emulsifiers. Preferred is where the cetyl dimethicone copolyol is in an admixture with other non-silicone organic emulsifiers and emollients.
- blends of 25-50% of the organosiloxane emulsifier, 25-50% of a non-silicone organic emulsifier, and 25-50% by weight emollients or oils are preferred.
- the mixtures identified by the C.T.F.A. names cetyl dimethicone copolyol (and) polyglyceryl 4-isostearate (and) hexyl laurate, or cetyl dimethicone copolyol (and) polyglyceryl-3 oleate (and) hexyl laurate both work well.
- ABIL WE 09 contains approximately, by weight of the total ABIL composition, 25-50% cetyl dimethicone copolyol, 25-50%, polyglyceryl 4-isostearate, and 25-50% of hexyl laurate which is an emollient or oil.
- emulsifiers sold by Union Carbide under the SilwetTM trademark. These emulsifiers are represented by the following generic formulas:
- R lower alkyl or hydrogen
- EO is polyethyleneoxy
- PO is polypropyleneoxy
- m and n are each independently 1-5000
- x and y are each independently 0-5000, and
- Me, m, n, x, y, EO and PO are as described above.
- the molecule contains a lipophilic portion and a hydrophilic portion.
- the lipophilic portion can be supplied by a sufficient number of methyl groups on the polymer backbone.
- n 1-10, preferably 8.
- Another preferred organosiloxane emulsifier for use in the compositions of the invention is dimethicone copolyol.
- organosiloxane surfactants or emulsifiers examples include amino/polyoxyalkyleneated polydiorganosiloxanes disclosed in U.S. Pat. No. 5,147,578. Also suitable are organosiloxanes sold by Goldschmidt under the ABIL trademark including ABIL B-9806, as well as those sold by Rhone-Poulenc under the Alkasil tradename. Also, organosiloxane emulsifiers sold by Amerchol under the Amersil tradename, including Amersil ME-358, Amersil DMC-287 and Amersil DMC-357 are suitable.
- Dow Corning surfactants such as Dow Corning 3225C Formulation Aid, Dow Corning 190 Surfactant, Dow Corning 193 Surfactant, Dow Corning Q2-5200, and the like are also suitable.
- surfactants sold under the tradename Silwet by Union Carbide and surfactants sold by Troy Corporation under the Troysol tradename, those sold by Taiwan Surfactant Co. under the tradename Ablusoft, those sold by Hoechst under the tradename Arkophob, are also suitable for use in the invention.
- surfactants are various organic surfactants such as anionic, nonionic, amphoteric, zwitterionic, or cationic surfactants.
- compositions of the invention comprise 0.5-20%, preferably 0.5-15%, more preferably 0.5-10%, of a surfactant.
- Suitable surfactants may be anionic, nonionic, amphoteric, or zwitterionic.
- Anionic surfactants include alkyl and alkyl ether sulfates generally having the formula ROSO 3 M and RO(C 2 H 4 O) x SO 3 M wherein R is alkyl or alkenyl of from about 10 to 20 carbon atoms, x is 1 to about 10 and M is a water soluble cation such as ammonium, sodium, potassium, or triethanolamine cation.
- anionic surfactant which may be used in the compositions of the invention are water soluble salts of organic, sulfric acid reaction products of the general formula:
- R 1 is chosen from the group consisting of a straight or branched chain, saturated aliphatic hydrocarbon radical having from about 8 to about 24 carbon atoms, preferably 12 to about 18 carbon atoms; and M is a cation.
- anionic surfactants are salts of organic sulfuric acid reaction products of hydrocarbons such as n-paraffins having 8 to 24 carbon atoms, and a sulfonating agent, such as sulfur trioxide.
- anionic surfactants are reaction products of fatty acids esterified with isethionic acid and neutralized with sodium hydroxide.
- the fatty acids may be derived from coconut oil, for example.
- succinates and succinimates are suitable anionic surfactants.
- This class includes compounds such as disodium N-octadecylsulfosuccinate; tetrasodium N-(1,2-dicarboxyethyl)-N-octadecylsulfosuccinate; and esters of sodium sulfosuccinic acid e.g. the dihexyl ester of sodium sulfosuccinic acid, the dioctyl ester of sodium sulfosuccinic acid, and the like.
- Suitable anionic surfactants include olefin sulfonates having about 12 to 24 carbon atoms.
- olefin sulfonate means a compound that can be produced by sulfonation of an alpha olefin by means of uncomplexed sulfur trioxide, followed by neutralization of the acid reaction mixture in conditions such that any sulfones which have been formed in the reaction are hydrolyzed to give the corresponding hydroxy-alkanesulfonates.
- the alpha-olefin from which the olefin sulfonate is derived is a mono-olefin having about 12 to 24 carbon atoms, preferably about 14 to 16 carbon atoms.
- Suitable anionic organic surfactants are the beta-alkoxy alkane sulfonates or water soluble soaps thereof such as the salts of C 10-20 fatty acids, for example coconut and allow based soaps.
- Preferred salts are ammonium, potassium, and sodium salts.
- Still another class of anionic surfactants include N-acyl amino acid surfactants and salts thereof (alkali, alkaline earth, and ammonium salts) having the formula:
- R 1 is a C 8-24 alkyl or alkenyl radical, preferably C 10-18 ;
- R 2 is H, C 1-4 alkyl, phenyl, or —CH 2 COOM;
- R 3 is CX 2 — or C 1-2 alkoxy, wherein each X independently is H or a C 1 alkyl or alkylester, n is from 1 to 4, and M is H or a salt forming cation as described above.
- N-acyl sarcosinates including lauroyl sarcosinate, myristoyl sarcosinate, cocoyl sarcosinate, and oleoyl sarcosinate, preferably in sodium or potassium forms.
- the composition can contain one or more nonionic surfactants.
- Nonionic surfactants are generally compounds produced by the condensation of alkylene oxide groups with a hydrophobic compound. Classes of nonionic surfactants are:
- sucrose esters of fatty acids examples include sucrose cocoate, sucrose behenate, and so on.
- (c) Polyethylene oxide condensates of alkyl phenols, for example the condensation products of alkyl phenols having an alkyl group of 6 to 20 carbon atoms With ethylene oxide being present in amounts of about 10 to 60 moles of ethylene oxide per mole of alkyl phenol.
- (e) Condensation products of aliphatic alcohols having 8 to 18 carbon atoms with ethylene oxide, for example a coconut alcohol/ethylene oxide condensate having 10 to 30 moles of ethylene oxide per mole of coconut alcohol, the coconut alcohol fraction having 10 to 14 carbon atoms.
- ethylene oxide for example a coconut alcohol/ethylene oxide condensate having 10 to 30 moles of ethylene oxide per mole of coconut alcohol, the coconut alcohol fraction having 10 to 14 carbon atoms.
- R 1 contains an alkyl, alkenyl or monohydroxyalkyl radical ranging from about 8 to 18 carbon atoms in length, from 0 to about 10 ethylene oxide moieties, and from 0 to about 1 glyceryl moiety and R 2 and R 3 are each alkyl or monohydroxyalkyl groups containing from about 1 to about 3 carbon atoms.
- R contains an alkyl, alkenyl, or monohydroxyalkyl radical having 8 to 18 carbon atoms, from 0-10 ethylene oxide moieties and 0 or 1 glyceryl moiety
- R 2 and R 3 are each alkyl or monohydroxyalkyl group containing from about 1 to 3 carbon atoms.
- alkyl polysaccharides having a hydrophobic group of 6 to 30, preferably 10, carbon atoms and a polysaccharide group such as glucose, galactose, etc.
- Suitable alkyl polysaccharides are octyl, nonydecyl, undecyldodecyl, tridecyl, tetradecyl, pentadecyl, hexadecyl, heptadecyl, and octadecyl, di-, tri-, tetra-, penta-, and hexaglucosides, galactosides, lactosides, giucoses, fructosides, fructoses, and so on.
- n is 5-200 and RC(O) is a hydrocarbylcarbonyl group wherein R is preferably an aliphatic radical having 7 to 19 carbon atoms.
- nonionic surfactants that may be used include C 10-18 alkyl(C 1-6 )polyhydroxy fatty acid amides such as C 12-18 methylglucamides, N-alkoxy polyhydroxy fatty acid amides, N-propyl through N-hexyl C 12-19 glucamides and so on.
- Amphoteric surfactants that can be used in the compositions of the invention are generally described as derivatives of aliphatic secondary or tertiary amines wherein one aliphatic radical is a straight or branched chain alkyl of 8 to 18 carbon atoms and the other aliphatic radical contains an anionic group such as carboxy, sulfonate, sulfate, phosphate, or phosphonate.
- Suitable amphoteric surfactants may be imidazolinium compounds having the general formula:
- R 1 is C 8-22 alkyl or alkenyl, preferably C 12-16 ;
- R 2 is hydrogen or CH 2 CO 2 M,
- R 3 is CH 2 CH 2 OH or CH 2 CH 2 OCH 2 CHCOOM;
- R 4 is hydrogen, CH 2 CH 2 OH, or CH 2 CH 2 OCH 2 CH 2 COOM,
- Z is CO 2 M or CH 2 CO 2 M,
- n is 2 or 3, preferably 2
- M is hydrogen or a cation such as an alkali metal, alkaline earth metal, ammonium, or alkanol ammonium. cation. Examples of such materials are marketed under the tradename MIRANOL, by Miranol, Inc.
- amphoteric surfactants are monocarboxylates or dicarboxylates such as cocamphocarboxypropionate, cocoamphocarboxypropionic acid, cocamphocarboxyglycinate, and cocoamphoacetate.
- amphoteric surfactants include aminoalkanoates of the formula
- n and m are 1 to 4, R is C 8-22 alkyl or alkenyl, and M is hydrogen, alkali metal, alkaline earth metal, ammonium or alkanolammonium.
- amphoteric surfactants include n-alkylaminopropionates and n-alkyliminodipropionates, which are sold under the trade name MIRATAINE by Miranol, Inc. or DERIPHAT by Henkel, for example N-lauryl-beta-amino propionic acid, N-lauryl-beta-imino-dipropionic acid, or mixtures thereof.
- Zwitterionic surfactants are also suitable for use in the compositions of the invention.
- the general formula for such surfactants is:
- R 2 contains an alky, alkenyl or hydroxy alkyl radical of from about 8 to about 18 carbon atoms, from 0 to about 10 ethylene oxide moieties and 0 or I glyceryl moiety;
- Y is selected from the group consisting of nitrogen, phosphorus, and sulfur atoms;
- R 3 is an alkyl or monohydroxyalkyl group containing about 1 to 3 carbon atoms;
- X is 1 when Y is a sulfur atom, and 2 when Y is a nitrogen or phosphorus atom;
- R 4 is an alkylene or hydroxyalkylene of from about 1 to about 4 carbon atoms, and Z is a radical selected from the group consisting of carboxylate, sulfonate, sulfate, phosphonate, and phosphate groups.
- Zwitterionics include betaines, for example higher alkyl betaines such as coco dimethyl carboxymethyl betaine, lauryl dimethyl carboxymethyl betaine, lauryl dimethyl alphacarboxyethyl betaine, cetyl dimethyl carboxymethyl betaine, lauryl bis-(2-hydroxyethyl)carboxymethyl betaine, stearyl bis-(2-hydroxypropyl)carboxymethyl betaine, oleyl dimethyl gamma-carboxylethyl betaine, and mixtures thereof.
- sulfo- and amido-betaines such as coco dimethyl sulfopropyl betaine, stearyl dimethyl sulfopropyl betaine, and the like.
- Cationic surfactants and/or polymers may be incorporated into the compositions of the invention. If so, 0.01-15%, preferably 0.05-10%, preferably 0.10-8% of a cationic ingredients is suggested. Suitable cationic ingredients include cationic polymers, quaternary ammonium salts, or the salts of fatty amines. Quaternary ammonium salts have the formula:
- R 1 is hydrogen, an aliphatic group of 1 to 22 carbon atoms, or aromatic, aryl, or alkaryl group having 12 to 22 carbon atoms
- R 2 is an aliphatic group having 1-22 carbon atoms
- R 3 and R 4 are each alkyl groups of from 1 to 3 carbon atoms
- X is an anion selected from halogen, acetate, phosphate, nitrate and methyl sulfate radicals.
- the aliphatic groups may contain, in addition to carbon and hydrogen atoms, ether linkages as well as amido groups.
- Suitable quaternary ammonium compounds may be mono-long chain alkyl, di-long chain alkyl, tri-long chain alkyl, and the like.
- Examples of such quaternary ammonium salts include behenalkonium chloride, behentrimonium chloride, behentrimonium methosulfate, benzalkonium chloride, benzethonium chloride, benzyl triethyl ammonium chloride, cetalkonium chloride, cetrimonium chloride, cetrimonium bromide, cetrimonium methosulfate, cetrimonium tosylate, cetylpyridinium chloride, dibehenyudiarachidyl dimonium chloride. dibehenyldimonium chloride, dibehenyldimonium methosulfate, dicapryl/dicaprylyl dimonium chloride, dicetyldimonium chloride, and mixtures thereof.
- quaternary ammonium salts useful as the cationic surfactant are compounds of the general formula:
- R 1 is an aliphatic group having 16 to 22 carbon atoms
- R 2 , R 3 , R 4 , R 5 , and R 6 are the same or different and are selected from H and alkyls having 1 to 4 carbon atoms and X is an anion as above defined.
- quaternary imidazolinium salts having the following general formula are also suitable:
- R 5 is hydrogen or a C 1-4 alkyl
- R 6 is a C 1-4 alkyl
- R 7 is a C 8-22 alkyl
- R 8 is hydrogen, or a C 1-22 alkyl
- X is an anion as defined above.
- cationic surfactant are salts of fatty primary, secondary, or tertiary amines, wherein the substituted groups have 12 to 22 carbon atoms.
- amines include dimethyl stearamine, dimethyl soyamine, stearylamine, myristylamine, tridecylamine, ethyl stearamine, and so on.
- cationic polymers such as:
- R is hydrogen or methyl, preferably methyl
- y is 0 or 1, preferably 1
- R 2 is O or NH, preferably NH
- R 3 is C x H 2x where x is 2 to 18, or —CH 2 —CHOH—CH—, preferably C x H 2x where x is 2;
- R 4 is methyl, ethyl, phenyl, or C 1-4 substituted phenyl, preferably methyl;
- R 5 is methyl or ethyl, preferably methyl.
- (d) Homopolymers or copolymers derived from acrylic or methacrylic acid wherein the monomer units are selected from the group consisting of acrylamide, methylacrylamide, diacetone-acrylamide, acrylamide or methacrylamide substituted on the nitrogen by lower alkyl, alkyl esters of acrylic acid and methacrylic acid, vinylpyrrolidone, and vinyl esters.
- cationic polymers that can be used in the compositions of the invention are the cationic polymers disclosed in U.S. Pat. Nos. 5,240,450 and 5,573,709, which are hereby incorporated by reference.
- compositions of the invention may contain 0.1-25%, preferably 0.5-20%, more preferably 1-15% by weight of the total composition of wax.
- Suitable waxes have a melting point of 35 to 120° C., and can be animal waxes, plant waxes, mineral waxes, silicone waxes, synthetic waxes, and petroleum waxes.
- waxes in accordance with the invention include bayberry, beeswax, candelilla, carnauba, ceresin, cetyl esters, hydrogenated jojoba oil, hydrogenated jojoba wax, hydrogenated microcrystalline wax, hydrogenated rice bran wax, japan wax, jojoba butter, jojoba esters, jojoba wax, lanolin wax, microcrystalline wax, mink wax, montan acid wax, montan wax, ouricury wax, ozokerite, paraffin, PEG-6 beeswax, PEG-8 beeswax, rice bran wax, shellac wax, spent grain wax, sulfurized jojoba oil, synthetic beeswax, synthetic candelilla wax, synthetic carnauba wax, synthetic japan wax, synthetic jojoba oil, ethylene homo- or copolymers, stearoxy dimethicone, dimethicone behenate, stearyl dimethicone, and the like, as well synthetic homo- and
- silicone resins include one or more branched chain silicone resins in the compositions of the invention. If so, a range of 0.001-20%, preferably 0.01-15%, more preferably 0.1-10%0/by weight of the total composition is suggested.
- suitable silicone resins include siloxy silicate polymers having the following general formula:
- R, R′ and R′′ are each independently a C 1-10 straight or branched chain alkyl or phenyl, and x and y are such that the ratio of (RR′R′′) 3 SiO 1/2 units to SiO 2 units is 0.5 to 1 to 1.5 to 1.
- R, R′ and R′′ are a C 1-6 alkyl, and more preferably are methyl and x and y are such that the ratio of (CH 3 ) 3 SiO 1/2 units to SiO 2 units is 0.75 to 1.
- this trimethylsiloxy silicate containing 2.4 to 2.9 weight percent hydroxyl groups which is formed by the reaction of the sodium salt of silicic acid, chlorotrimethylsilane, and isopropyl alcohol.
- the manufacture of trimethylsiloxy silicate is set forth in U.S. Pat. Nos. 2,676,182; 3,541,205; and 3,836,437, all of which are hereby incorporated by reference.
- Trimethylsiloxy silicate as described is available from Dow Corning Corporation under the tradename 2-0749 and 2-0747, which is a blend of about 40-60% volatile silicone and 40-60% trimethylsiloxy silicate.
- Dow Corning 2-0749 in particular, is a fluid containing about 50% trimethylsiloxy silicate and about 50% cyclomethicone. The fluid has a viscosity of 200-700 centipoise at 25° C., a specific gravity of 1.00 to 1.10 at 25° C., and a refractive index of 1.40-1.41.
- branched chain silicone resins are silicone esters comprising units of the general formula R a R E b SiO [4 ⁇ (a+b)/2] or R 13 x R E y SiO 1/2 , wherein R and R 13 are each independently an organic radical such as alkyl, cycloalkyl, or aryl, or, for example, methyl, ethyl, propyl, hexyl, octyl, decyl, aryl, cyclohexyl, and the like.
- R E is a carboxylic ester containing radical.
- Preferred R E radicals are those wherein the ester group is formed of one or more fatty acid moieities (e.g. of about 6, often about 6 to 30 carbon atoms) and one or more aliphatic alcohol moieities (e.g. of about 10 to 30 carbon atoms).
- Such acid moieities include those derived from branched-chain fatty acids such as isostearic, or straight chain fatty acids such as behenic.
- suitable alcohol moieties include those derived from monohydric or polyhydric alcohols, e.g. normal alkanols such as n-propanol and branched-chain etheralkanols such as (3,3,3-trimethylolpropoxypropane.
- the ester subgroup i.e. the group containing the carboxylic ester
- the cross-linked silicone ester can be a liquid or solid at room temperature. Preferably it will have a waxy feel and a molecular weight of no more than about 100,000 daltons.
- composition of the invention may contain 0.001-35%, preferably 0.01-20% more preferably 0.1-10%, by weight of the total composition, of dry particulate matter having a particle size of 0.02 to 200, preferably 0.5 to 100, microns.
- the particulate matter may be colored or non-colored (for example white).
- Suitable powders include bismuth oxychloride, titanated mica, fumed silica, spherical silica, polymethylmethacrylate, micronized teflon, boron nitride, acrylate copolymers, aluminum silicate, aluminum starch octenylsuccinate, bentonite, calcium silicate, cellulose, chalk, corn starch, diatomaceous earth, fuller's earth, glyceryl starch, hectorite, hydrated silica, kaolin, magnesium aluminum silicate, magnesium trisilicate, maltodextrin, montmorillonite, microcrystalline cellulose, rice starch, silica, talc, mica, titanium dioxide, zinc laurate, zinc myristate, zinc rosinate, alumina, attapulgite, calcium carbonate, calcium silicate, dextran, kaolin, nylon, silica silylate, silk powder, sericite, soy flour, tin oxide, titanium hydrox
- the powder component also may comprise various organic and inorganic pigments.
- the organic pigments are generally various aromatic types including azo, indigoid, triphenylmethane, anthraquinone, and xanthine dyes which are designated as D&C and FD&C blues, browns, greens, oranges, reds, yellows, etc.
- Organic pigments generally consist of insoluble metallic salts of certified color additives, referred to as the Lakes.
- Inorganic pigments include iron oxides, ultramarines, chromium, chromium hydroxide colors, and mixtures thereof.
- the composition may contain a mixture of both pigmented and non-pigmented powders.
- the percentage of pigments used in the powder component will depend on the type of cosmetic being formulated.
- compositions of the invention may contain 0.001-20%, preferably 0.01-10%, more preferably 0.05-8% of one or more sunscreens.
- a sunscreen is defined as an ingredient that absorbs at least 85 percent of the light in the UV range at wavelengths from 290 to 320 nanometers, but transmit UV light at wavelengths longer than 320 nanometers.
- Sunscreens generally work in one of two ways. Particulate materials, such as zinc oxide or titanium dioxide, as mentioned above, physically block ultraviolet radiation. Chemical sunscreens, on the other hand, operate by chemically reacting upon exposure to UV radiation. Suitable sunscreens that may be included in the compositions of the invention are set forth on page 582 of the CTFA Cosmetic Ingredient Handbook, Second Edition, 1992, as well as U.S. Pat. No.
- sunscreen materials are p-aminobenzoic acid (PABA), cinoxate, diethanolamine p-methoxycinnamate (DEA-methoxycinnamate), Digalloyl trioleate, dioxybenzone (Benzophenone-8), ethyl 4-[bis-(hydroxypropyl)] amnobenzoate (ethyl dihydroxypropyl PABA), 2-ethythexyl-2-cyano-3,3-diphenylacrylate (octocrylene), ethylhexyl p-methoxycinnamate (Octyl methoxycinnamate), 2-ethylhexyl salicylate (Octyl salicylate), glyceryl aminobenzoate (Glyceryl PABA), homosalate, lawsone with dihydroxyacetone, menthyl anthranilate, oxybenzone (Benzophenone
- the composition may contain 0.0001-8%, preferably 0.001-6%, more preferably 0.005-5% by weight of the total composition of preservatives.
- preservatives include such as benzoic acid, benzyl alcohol, benzylhemiformal, benzylparaben, 5-bromo-5-nitro-1,3-dioxane, 2-bromo-2-nitropropane-1,3-diol, butyl paraben, calcium benzoate, calcium propionate, captan, chlorhexidine diacetate, chlorhexidine digluconate, chlorhexidine dihydrochloride, chloroacetamide, chlorobutanol, p-chloro-m-cresol, chlorophene, chlorothymol, chloroxylenol, m cresol, o-cresol, DEDM Hydantoin, DEDM Hydantoin dilaurate, dehydroacetic acid, diazolidinyl urea variety of preservatives
- compositions of the invention may contain vitamins and/or coenzymes, as well as antioxidants. If so, 0.001-10%, preferably 0.01-8%, more preferably 0.05-5% by weight of the total composition are suggested.
- Suitable vitamins include the B vitamins such as thiamine, riboflavin, pyridoxin, and so on, as well as coenzymes such as thiamine pyrophoshate, flavin adenin dinucleotide, folic acid, pyridoxal phosphate, tetrahydrofolic acid, and so on.
- Vitamin A and derivatives thereof are suitable. Examples are Vitamin A palmitate, acetate, or other esters thereof, as well as Vitamin A in the form of beta carotene.
- Vitamin E and derivatives thereof such as Vitamin E acetate, nicotinate, or other esters thereof.
- Vitamins D and K are suitable.
- Suitable antioxidants are ingredients which assist in preventing or retarding spoilage.
- antioxidants suitable for use in the compositions of the invention are potassium sulfite, sodium bisulfite, sodium erythrobate, sodium metabisulfite, sodium sulfite, propyl gallate, cysteine hydrochloride, butylated hydroxytoluene, butylated hydroxyanisole, and so on.
- alpha or beta hydroxy acids or alpha ketoacids may be added to the compositions of the invention. Suggested ranges are 0.01-20%, preferably 0.1-15%, more preferably 0.5-10% by weight of the total composition. Suitable alpha hydroxy acids and alpha ketoacids are disclosed in U.S. Pat. No. 5,091,171, which is hereby incorporated by reference. Such alpha hydroxy acids are as follows:
- Ra and Rb are H, F, Cl, Br, alkyl, aralkyl, or aryl group of saturated, unsaturated, straight or branched chain or cyclic form having 1-10 carbon atoms, and in addition Ra or Rb may carry OH, CHO, COOH and alkoxy groups having 1 to 9 carbon atoms.
- the second group of alpha hydroxy acids may be represented by the following formula:
- Ra and Rb are H, alkyl, aralkyl, or aryl groups of straight or branched chain saturated or unsaturated alkyl having 1 to 10 carbon atoms, and in addition Ra may carry F, Cl, Br, I, OH, CHO, COOH, and alkoxy groups having 1 to 10 carbon atoms.
- the alpha hydroxy acids may exist in the keto acid form, or the ester form.
- alpha hydroxy acids include glycolic acid, malic acid, pyruvic acid, mandelic acid, lactic acid, methyllactic acid, and so on.
- beta hydroxy acids such as salicylic acid, and derivatives thereof may be included in the compositions of the invention.
- the anhydrous emulsions of the invention are made by first subjecting the nonaqueous polar organic solvent to an input of energy, preferably heat energy.
- energy preferably heat energy.
- the nonaqueous polar organic solvent is heated to a temperature sufficient to dissolve the ascorbic acid.
- a temperature above room temperature is generally required to achieve solubilization of ascorbic acid to any appreciable degree.
- the nonaqueous polar organic solvent is heated to a temperature of about 70 to 170, more preferably about 80 to 120, more preferably about 90-110, and most preferably about 95-105° C.
- the heat energy required may depend on conditions such as the pressure at which the nonaqueous polar organic solvent is maintained.
- the temperature required to dissolve appreciable levels of ascorbic acid in the solvent is correspondingly less.
- the temperature required to dissolve appreciable levels of ascorbic acid may be correspondingly greater.
- the energy source may be standard heat as well as heat radiation from sources such as long and short microwaves, infrared radiation, sonication, microfluidization, and the like.
- the ascorbic acid is added to the nonaqueous polar organic solvent with stirring until dissolved.
- the temperature of the mixture is then reduced, i.e. the mixture is cooled, by reducing the temperature by 10 to 145° C., more preferably by 20 to 100° C., most preferably by 40 to 95° C.
- Most preferably the mixture is cooled to room temperature. It is preferred to cool the mixture to room temperature quickly, for example by plunging a container of the mixture into an ice water bath until the mixture attains room temperature.
- one of the nonaqueous polar organic solvents is heated in a vessel to about 100° C.
- the ascorbic acid is added with stirring until dissolved.
- the vessel containing the mixture is then plunged into an ice water bath and held there until it has cooled to room temperature.
- the mixture is reheated to a temperature of 70-170°, 80-110°, preferably 95-105°, more preferably about 100° C. and the second nonaqueous polar organic solvent is added with stirring.
- the mixture is then rapidly cooled to room temperature by putting it into an ice water bath.
- the ascorbic acid solubilized in the nonaqueous polar organic solvent is emulsified into the nonaqueous nonpolar organic solvent at room temperature by homogenizing by using standard homogenizing equipment such as the Eppenbach Homo-mixer.
- the nonaqueous nonpolar organic solvent is emulsified into the ascorbic acid mixture at room temperature using homogenization.
- An anhydrous emulsion suitable as a skin lotion was made in accordance with the invention as follows: w/w % Cetyl dimethicone copolyol 3.00 (surfactant) Hydrogenated castor oil 5.00 (wax) Polyethylene 1.00 (wax) Polyglyceryl-4-isostearate 1.50 (surfactant) Polyethylene/mineral oil 15.00 (wax/nonpolar organic solvent) (6:94) Cyclomethicone 12.00 (nonpolar organic solvent) C 12-15 alkyl benzoate 12.50 (nonpolar organic solvent) Glycerine 33.40 (polar organic solvent) PEG-6 6.70 (polar organic solvent) Ascorbic acid 10.00
- the glycerine was heated to a temperature of 100° C.
- the ascorbic acid was added to the glycerine while maintaining the temperature at 100° C., while stirring until dissolved.
- the solution was then put into an ice water bath until the mixture cooled to room temperature.
- the mixture was a clear solution.
- the mixture was then heated back up to 100° C., and the PEG-6 was added to the hot mixture with stirring.
- the mixture was then put into an ice water bath again until cooled to room temperature.
- An anhydrous emulsion suitable for use as a skin lotion was made as follows: w/w % Dimethicone copolyol/cyclomethicone 10.50 (surfactant/nonpolar (10:90) organic solvent) Cetyl dimethicone copolyol 1.00 (surfactant) Trihydroxystearin/cyclomethicone 9.50 (nonpolar organic (17.5:82.5) solvent/nonpolar organic solvent) Dimethiconol/cyclomethicone 2.00 (surfactant/nonpolar (13:87) organic solvent) PEG-6 31.00 (polar organic solvent) Glycerin 35.40 (polar organic solvent) Ascorbic acid 10.60
- the glycerin was heated to a temperature of 100° C.
- the ascorbic acid was added to the heated mixture while maintaining the temperature at 100° C., and stirring until dissolved.
- the mixture was then put into an ice water bath until the mixture cooled to room temperature.
- the mixture was then heated back up to 100° C., and the PEG-6 was added to the hot mixture with stirring.
- the mixture was then put into an ice water bath until cooled to room temperature.
- Anhydrous emulsions suitable for use as a skin treatment lotion and cream were prepared as follows: 1 2 Ascorbic acid 10.00 10.00 PEG-6 (nonaqueous polar organic solvent) 33.7 6.7 Glycerine (nonaqueous polar organic solvent) 33.3 33.3 Octyl methoxycinnamate (sunscreen) 7.5 — Safflower oil (nonaqueous nonpolar organic solvent) 7.5 — Tocopheryl acetate (vitamin) 1.0 — Polyacrylamide/C13-14 isoparaffin/laureth-7 1.0 — Sorbitan oleate (surfactant) 2.7 — Polysorbate 80 (nonaqueous polar organic solvent) 3.3 — Steareth-21 (surfactant) — 12.0 Steareth-2 (surfactant) — 4.0 Polysorbate 20 (nonaqueous polar organic solvent) — 1.0 Glyceryl stearate (nonaqueous nonpolar organic solvent) — 8.0 Cetyl
- the glycerine was heated to a temperature of 100° C.
- the ascorbic acid was added to the heated mixture while maintaining the temperature at 100° C. and stirring until dissolved.
- the mixture was then put into an ice water bath until the mixture cooled to room temperature.
- the mixture was then heated back up to 100° C., and the PEG-6 was added to the hot mixture with stirring.
- the mixture was then put into an ice water bath until cooled to room temperature.
- Sample 1 provided a pourable translucent gel-like emulsion.
- Sample 2 provided a non-pourable opaque cream.
- the solubility of ascorbic acid in various solvents was correlated with the octanol/water partition coefficient of the solvent.
- the partition coefficient of each solvent was measured using a software program marketed by Advanced Chemistry Development, Inc., called the ACD/LogP program, which calculates the partition coefficient from the molecular structure of the solvent.
- the solubility of the ascorbic acid was determined by heating the solvent to a temperature in excess of 100° C., preferably in the range of 105 to 110° C. while monitoring with a thermometer. Measured amounts (in weight percent, i.e. 1%, 2%, 3%, 4%, 5%, up to 20%, 25%, etc.) of ascorbic acid were added to separate tubes containing the hot solvent while mixing.
- the solubility of ascorbic acid in the particular solvent was the maximum weight percent of ascorbic acid that could be solubilized in the solvent before the solution turned cloudy and crystal formation occurred at room temperature after one month.
- the solubility was determined to be the maximum weight percent of ascorbic acid that could be solubilized in the solvent, where the solution remained clear and no microscopic evidence of crystal formation was evident at room temperature after one month.
- the solvents which exhibit octanol/water partition coefficients of less than ⁇ 0.2 may be used as the nonaqueous polar organic solvent.
- the solvents which exhibit octanol/water partition coefficients of greater than ⁇ 0.2 may be used as the nonaqueous nonpolar organic solvent.
- Example 2 Stability studies were performed on the formula of Example 2, containing 10.6% ascorbic acid, as follows: Time Temperature % Ascorbic Acid Remaining 5 months 25° C. 9.6% 5 months 40° C. 9.6% 5 months 50° C. 6.6%
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Abstract
A composition in the form of an anhydrous emulsion having as a dispersed phase ascorbic acid dissolved in a nonaqueous polar organic solvent, and as the continous phase a nonaqueous nonpolar organic solvent, as well as a method for dissolving ascorbic acid.
Description
- The invention pertains to the field of compositions, particularly cosmetic compositions, containing ascorbic acid in bioavailable form.
- It is well known that aging of the skin is due, at least in part, to continual stretching and contraction of both the dermal and epidermal layers of the skin and disruption of the collagen bundles which provide support to the epidermis. Collagen consists of long elastic polypeptide fibers interconnected by bridges which provide the cohesion and stability of connective tissue. This enables collagen to act as an elastic tissue in every direction and retain water. Collagen aging manifests itself as a break in connection between the collagen fibers. Age, severe weather, and pollution accelerate the breaks and slow down renewal of the collagen structure.
- Ascorbic acid, or Vitamin C, has many known biological functions. The L-ascorbic acid isomer is biologically active and is known to stimulate the synthesis of collagen, act as a free radical scavenger, and minimize lipid peroxidation and other forms of cellular damage associated with aging
-
- Ascorbic acid is highly soluble, but extremely unstable, in water and rapidly decomposes to form dehydroascorbic acid. This degradation is even more pronounced in the presence of oxygen. It is known that ascorbic acid is much more stable in nonaqueous polar solvents such as polyols, but unfortnately its solubility is limited in such solvents and it generally is thought to be not possible to obtain stable ascorbic acid solutions of more than several percent by weight concentration. Since the anti-aging effects of ascorbic acid are known to be dose-dependent, it is desirable to make stable cosmetic compositions containing ascorbic acid dispersed in a cosmetically acceptable carrier at a concentration of greater than about 5 weight percent, preferably up to 20 or 30 weight percent.
- Numerous patents and publications teach various ways of stabilizing ascorbic acid. For example, European Patent Publication No. 0 729 746 teaches an ascorbic acid delivery system comprised of a two compartment kit. In the first compartment is an anhydrous solution of ascorbic acid dissolved in a nonaqueous polar solvent such as a polyol. In the second compartment is an alkaline aqueous solution. The contents of the two compartments are mixed immediately prior to use. The more alkaline aqueous solution increases the pH of the anhydrous ascorbic acid containing solution to provide a composition which does not tingle the skin.
- U.S. Pat. No. 5,350,773 teaches stable liquid products used for liquid human and animal food. The compositions are in the form of anhydrous emulsions containing a nonpolar fatty material as the dispersed phase and a polar nonaqueous solvent as the continuous phase. Esters of ascorbic acid are used as the emulsifying agent.
- U.S. Pat. No. 5,427,814 teaches a method for protecting a fat against oxidation by mixing ascorbic acid into a polar solvent, and adding the mixture to a heated mixture of tocopherol and lecithin. The polar solvent is then evaporated from the mixture by subjecting the mixture to heat for a period of time.
- U.S. Pat. No. 5,308,621 teaches a method for transdermal administration of ascorbic acid. Fine particulate ascorbic acid is suspended in a pharmaceutically acceptable carrier such as a polyol. The compositions are topically applied and the particulate ascorbic acid dissolves upon contact with skin and is absorbed into the skin.
- European Patent Publication No. 0 755 674 teaches stabilized ascorbic acid compositions containing a water activity value of less than 0.85. The compositions contain a minimum level of water, in addition to a polyol and an oil.
- U.S. Pat. No. 5,587,149 teaches ascorbic acid emulsion compositions comprising ascorbic acid solubilized in a polyol as the dispersed phase and oil as the continuous phase.
- However, none of the above patents teach a stable anhydrous ascorbic acid containing composition suitable for cosmetic application where high levels of ascorbic acid are solubilized in the composition and remain stable over protracted periods of time. By “solubilized” it is meant either dissolved or emulsified, but not merely suspended.
- An object of the invention is to provide a method for stabilizing ascorbic acid to enable its use in cosmetic products which have anti-aging effects.
- Another object of the invention is to provide a stabilized ascorbic acid composition suitable for use in cosmetics.
- Another object of the invention is to provide a stabilized ascorbic acid composition containing ascorbic acid at significant concentrations.
- Another object of the invention is to provide a stabilized ascorbic acid composition in an anhydrous emulsion form which contains ascorbic acid at significant concentrations.
- The invention comprises a composition in the form of an anhydrous emulsion having as a dispersed phase, ascorbic acid dissolved by means of energy input, in a nonaqueous polar organic solvent, and as the continuous phase a nonaqueous nonpolar organic solvent.
- The invention comprises a composition in the form of an anhydrous emulsion having as the dispersed phase a nonaqueous nonpolar organic solvent, and as the continuous phase ascorbic acid dissolved in a nonaqueous polar organic solvent.
- The invention is also directed to a method for dissolving ascorbic acid in a nonaqueous polar organic solvent comprising the steps of:
- a) heating the nonaqueous polar organic solvent to a temperature sufficient to dissolve ascorbic acid,
- b) dissolving particulate ascorbic acid in the heated carrier composition, and
- c) reducing the temperature of the mixture, preferably to approximately room temperature.
- The invention is also directed to a method for making an anhydrous emulsion having as a dispersed phase ascorbic acid dissolved in a nonaqueous polar organic solvent, and as the continuous phase a nonaqueous nonpolar organic solvent, comprising the steps of:
- (a) heating the nonaqueous polar organic solvent to a temperature sufficient to dissolve ascorbic acid,
- (b) dissolving particulate ascorbic acid in the heated nonaqueous polar organic solvent,
- (c) reducing the temperature of the mixture, preferably to approximately room temperature,
- (d) emulsifying the ascorbic acid mixture into the nonaqueous nonpolar organic solvent.
- The invention also comprises a method for making an anhydrous emulsion having as the dispersed phase a nonaqueous nonpolar organic solvent, and as the continuous phase ascorbic acid dissolved in a nonaqueous polar organic solvent, comprising the steps of:
- (a) heating the nonaqueous polar organic solvent to a temperature sufficient to dissolve ascorbic acid,
- (b) dissolving particulate ascorbic acid in the heated nonaqueous polar organic solvent,
- (c) reducing the temperature of the mixture, preferably to room temperature,
- (d) emulsifying the nonaqueous nonpolar organic solvent into the solubilized ascorbic acid mixture.
- The invention is directed to cosmetic compositions comprising, by weight of the total composition:
- 0.1-50% ascorbic acid,
- 5-98% of a nonaqueous polar organic solvent,
- 5-98% of a nonaqueous nonpolar organic solvent.
- Definitions
- The term “ascorbic acid” when used in accordance with this invention means L-ascorbic acid, the bioavailable form, and derivatives thereof.
- The term “partition coefficient” when used in accordance with the invention means the octanol/water partition coefficient of the solvent as calculated by the ACD/LogP software program marketed by Advanced Chemistry Development, Inc. The software calculates the partition coefficient based upon the molecular structure of the solvent. Actual chemical measurement of partition coefficients may be difficult. The partition coefficient is defined as, in the equilibrium distribution of the solvent between two liquid phases, one of which is water and the other of which is octanol, the ratio of the solvent concentration in the octanol phase to the solvent concentration in the water phase.
- The term “polar” means, when used to characterize the solvent, that the logarithm of the octanol/water partition coefficient of the solvent as measured by the ACD/LogP software program, is less than or equal to −0.2 at room temperature. Thus, a polar solvent is one which is capable of solubilizing at least 2 weight percent or more of ascorbic acid at room temperature (generally 25° C.)
- The term “nonpolar” means, with respect to the solvent, that the logarithm of the octanol/water partition coefficient of the solvent as measured by the ACD/LogP software program, is greater than −0.2 at room temperature. Thus, a nonpolar solvent is one which is capable of solubilizing less than 2 weight percent of ascorbic acid at room temperature.
- The term “anhydrous” means that no substantial amount of water is added to the compositions of the invention. Trace amounts of water (for example, supplied as an impurity in the raw materials used to make the compositions of the invention) may still be presents e.g. in an amount less than about 5% by weight of the total composition, preferably less than 1 to 3% by weight of the total composition.
- The term “dissolved” or “dissolving” means that the ascorbic acid is essentially solubilized or dissolved in the nonaqueous polar organic solvent, and that the ascorbic acid will not exist to any appreciable degree in the particulate or crystalline form.
- The compositions of the invention may be liquid, semi-solid, or solid at room temperature. The compositions exist in an anhydrous emulsion form. The term “emulsion” is generally used in the cosmetic art to mean water-in-oil or oil-in-water emulsions. However, the compositions of the invention are anhydrous emulsions wherein one anhydrous phase (‘the dispersed phase’) is dispersed into another anhydrous phase (“the continuous phase”). In the anhydrous emulsions of the invention, the ascorbic acid dissolved into the nonaqueous polar organic solvent forms the dispersed phase. The nonaqueous nonpolar organic solvent forms the continuous phase.
- All percentages mentioned herein are percentages by weight unless otherwise indicated.
- The Nonaqueous Polar Organic Solvent
- The anhydrous emulsions of the invention contain 1-99%, preferably 20-80%, more preferably 40-60% by weight of the total composition, of a nonaqueous polar organic solvent. A variety of nonaqueous polar organic solvents are suitable for use in the dispersed phase of the anhydrous emulsion. As mentioned above, a solvent, in particular a nonaqueous solvent, is considered “polar” in the context of the invention if the logarithm of the partition coefficient of the solvent is less than or equal to −0.2 at room temperature. Examples are as follows.
- Polyols
- Polyols are suitable nonaqueous polar organic solvents. For purposes of this specification, polyols are defined as compounds which contain three or more hydroxyl groups per molecule. Examples of suitable polyols include fructose, glucamine, glucose, glucose glutamate, glucuronic acid, glycerin, 1,2,6hexanetriol, hydroxystearyl methylglucanine, inositol, lactose, malitol, mannitol, methyl gluceth-10, methyl gluceth-20, methyl glucose dioleate, methyl glucose sesquicaprylate/sesquicaprate, methyl glucose sesquicocoate, methyl glucose sesquiisostearate, methyl glucose sesquilaurate, methyl glucose sesquistearate, phytantriol, riboflavin, sorbeth-6, sorbeth-20, sorbeth-30, sorbeth-40, sorbitol, sucrose, thioglycerin, xylitol, and mix thereof. An especially preferred polyol is glycerin.
- Polymeric or Monomeric Ethers
- Also suitable as the nonaqueous polar organic solvent are homopolymeric or block copolymeric liquid ethers. Polymeric ethers are preferably formed by polymerization of monomeric alkylene oxides, generally ethylene or propylene oxides. Preferred monomeric ethers are those exhibiting the structure below were n=1. Preferred polymeric ethers exhibit the general structure below wherein n=2 to 20:
- where R is H or C1-10 straight or branched chain alkyl, and n is 1 to 20. Examples of such polymeric ethers include PEG, PPG, and derivatives thereof.
-
- wherein x is 1-200, y is 1-200 and z is 1-200. Such compounds are sold under the CTFA name Meroxapol 105, 108, 171, 172, 174, 178, 251, 252, 254, 255, 258, 311, 312, and 314.
- Mono- and Dihydric Alcohols
- Also suitable for use as to the nonaqueous polar organic solvent are mono- and dihydric alcohols of the general formula R(OH)n where n is 1 or 2 and R is a substituted or unsubstituted saturated C2-10, preferably C1-8 alkyl, or a substituted or unsubstituted alicyclic, bicyclic, or aromatic ring, with the substituents selected from halogen, alkoxy, hydroxy, and so on. Examples of suitable alcohols include monohydric alcohols such as ethanol, isopropanol, hexyldecanol, benzyl alcohol, propyl alcohol, and isopropyl alcohol, as well as dihydric alcohols such as hexylene glycol, diethylene glycol, ethylene glycol, propylene glycol, 1,2-butylene glycol, triethylene glycol, dipropylene glycol, and mixtures thereof.
- Sorbitan Derivatives
- Sorbitan derivatives, which are defined as ethers or esters of sorbitan, are also suitable polar solvents. Examples of suitable sorbitan derivatives are the Polysorbates, which are defined as stearate esters of sorbitol and sorbitan anhydrides, such as Polysorbate 20, 21, 40, 60, 61, 65, 80, 81, and 85. Also suitable are fatty esters of hexitol anhydrides derived from sorbitol, such as sorbitan trioleate, sorbitan tristearate, sorbitan sesquistearate, sorbitan stearate, sorbitan palmitate, sorbitan oleate, and mixtures thereof.
- Other nonaqueous polar solvents will also work in the claimed compositions, provided the logarithm of the measured partition coefficient of the solvent is less than −0.2 at room temperature.
- The Nonaqueous Nonpolar Organic Solvent
- The anhydrous emulsions of the invention contain 1-99%, preferably 20-80%, more preferably 4060%, by weight of total composition, of a nonaqueous nonpolar organic solvent as the continuous phase. Such solvents are defined as those where the logarithm of the partition coefficient is greater than −0.2 at room temperature. A variety of nonaqueous nonpolar organic solvents can be used in the compositions of the invention.
- Silicones
- Silicones are suitable nonpolar compounds. The silicones may be volatile or non-volatile. The term “volatile” means that the silicone has a measureable vapor pressure, i.e. a vapor pressure of at least 2 mm. of mercury at 20° C. If volatile, the silicone generally will have a viscosity of 0.5 to 25 centistokes at 25° C. Suitable volatile silicones include cyclic silicones, linear silicones, or mixtures thereof. Cyclic silicones (or cyclomethicones) are of the general formula:
- wherein n 3-7, and R1 and R2 are each independently H, C1-8 alkyl, aryl, aralkyl, alkenyl, or a cylic or alicylic ring. Preferably R1 and R2 are each independently H or CH3. Most preferably R1 and R2 are each CH3.
- Linear volatile silicones in accordance with the invention have the general formula:
- (CH3)3Si—O—[Si(CH3)2—O]n—Si(CH3)3
- where n=0-7, preferably 0-5.
- Linear and cyclic volatile silicones are available from various commercial sources including Dow Corning Corporation and General Electric. The Dow Corning volatile silicones are sold under the tradenames Dow Corning 244, 245, 344, and 200 fluids. These fluids comprise octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, hexamethyldisiloxane, and mixtures thereof.
- The silicone may also be nonvolatile, and in particular water insoluble nonvolatile silicones. The term “nonvolatile” means that the silicone has a vapor pressure of less than 2 mm. of mercury at 20° C. A variety of silicones fit this definition including dimethicone, phenyl trimethicone, diphenyl dimethicone, methicone, hexadecyl methicone, stearoxydimethicone, stearyl dimethicone, cetyl dimethicone, and so on.
- Cyclomethicone is the preferred silicone for use in the compositions of the invention.
- Esters
- In addition to the sorbitan esters, other esters are also suitable as the nonaqueous nonpolar organic solvent. In general such esters have the formula RCO—OR wherein each R is independently a C1-25 straight or branched chain saturated or unsaturated alkyl, alkylcarbonyloxyalkyl, or alkoxycarbonylalkyl, aryl, which may be substituted or unsubstituted with halogen, hydroxyl, alkyl, and the like.
- Examples of suitable esters include alkyl acetates, alkyl behenates, alkyl lactates, alkyl benzoates, alkyl octanoates, alkyl salicylates, and in particular C12-15 alkyl benzoate. Examples of further esters are set forth on pages 502-506 of the CTFA Cosmetic Ingredient Handbook, Second Edition, 1992, which is hereby incorporated by reference.
- Fats and Oils
- Fats and oils are also suitable as the nonaqueous nonpolar organic solvent. Preferably these materials are liquids or semi-solids at room temperature. They are generally defined as glyceryl esters of fatty acids (triglycerides), as well as the synthetically prepared esters of glycerin and fatty acids having the following general formula:
- wherein R, R′, and R″ are each independently fatty acid radicals. Examples of such materials include oils such as apricot kernel oil, avocado oil, canola oil, olive oil, sesame oil, peanut oil, soybean oil, trilinolenin, trilinolein, trioctanoin, tristearin, triolein, sesame oil, rapeseed oil, sunflower seed oil, and so on.
- Fatty Acids
- Fatty acids are also suitable as the nonaqueous nonpolar organic solvent in the compositions of the invention. Preferably the fatty acids are liquid or semi solid at room temperature. Fatty acids are the carboxylic acids obtained by hydrolysis of animal or vegetable fats and oils. Carboxylic acids having alkyl chains shorter than about seven carbon atoms are not generally considered fatty acids. Fatty acids have the general structure R—COOH where R is a straight or branched chain saturated or unsaturated C7-65 alkyl. Examples of suitable fatty acids include arachidic acid, arachidonic acid, behenic acid, capric acid, caproic acid, caprylic acid, coconut acid, corn acid, cottonseed acid, hydrogenated coconut acid, hydroxystearic acid, lauric acid, linoleic acid, linolenic acid, linseed acid, myristic acid, oleic acid, palmitic acid, palm kernel acid, soy acid, tallow acid, and the like.
- Fatty Alcohols
- Fatty alcohols may also be used as the nonaqueous nonpolar organic solvent. Fatty alcohols are generally made by reducing the fatty acid —COOH group to the hydroxyl function. They generally have the formula RCH2OH. Examples of fatty alcohols are behenyl alcohol, C9-11 alcohol, C12-13 alcohol, C12-15 alcohol, C12-16 alcohol, caprylic alcohol, cetearyl alcohol, cetyl alcohol, coconut alcohol, decyl alcohol, lauryl alcohol, myristyl alcohol, oleyl alcohol, and the like.
- Hydrocarbons
- Hydrocarbons are also good nonaqueous nonpolar organic solvents in accordance with the invention. Examples of suitable hydrocarbons include C7-60 isoparaffins, ethane, heptane, hexane, hydrogenated polyisobutene, isobutane, isododecane, isoeicosane, isohexadecane, isopentane, microcrystalline wax, mineral oil, mineral spirits, paraffin, petrolatum, petroleum distillates, squalene, polyethylene, and mixtures thereof. Preferred hydrocarbons are mineral oil and polyethylene.
- Lanolin and Lanolin Derivatives
- Also suitable as the nonaqueous nonpolar organic solvent are lanolin and derivatives thereof. Examples of such materials include acetylated hydrogenated lanolin, acetylated lanolin alcohol, laneth, lanolin acid, lanolin oil, lanolin alcohol, lanolin wax, and so on.
- Other Ingredients
- It may also be desired to include certain other ingredients in the anhydrous emulsions of the invention, such as surfactants, waxes, colorants, preservatives, and so on.
- Surfactants
- Silicone Surfactants
- The compositions may contain 0.1-15%, preferably 0.5-10%, more preferably 1-8% by weight of the total composition of one or more surfactants. The term “surfactant” is defined, in accordance with the invention, as a compound having at least one hydrophilic moiety and at least one lipophilic moiety. The surfactants may be silicone surfactants (also referred to as organosiloxane emulsifiers) or organic surfactants.
- Suitable silicone surfactants used in the compositions of the invention may be liquid or solid at room temperature and are generally a water-in-oil or oil-in-water type surfactants which are preferably nonionic, having an Hydrophile/Lipophile Balance (HLB) of 2 to 18. Preferably the organosiloxane is a nonionic surfactant having an HLB of 2 to 12, preferably 2 to 10, most preferably 4 to 6. The HLB of a nonionic surfactant is the balance between the hydrophilic and lipophilic portions of the surfactant and is calculated according to the following formula:
- HLB=7+11.7×log M w /M o
- where Mw is the molecular weight of the hydrophilic group portion and Mo is the molecular weight of the lipophilic group portion.
- Another method of calculating HLB is:
- HLB=20(1−S/A)
- where S is the saponification number of the surfactant and A is the acid number of the surfactant.
- The silicone surfactant or emulsifier used in the compositions of the invention is a polymer containing a polymeric backbone including repeating siloxy units that may have cyclic, linear or branched repeating units, e.g. di(lower)alkylsiloxy units, preferably dimethylsiloxy units. The hydrophilic portion of the organosiloxane is generally achieved by substitution onto the polymeric backbone of a radical that confers hydrophilic properties to a portion of the molecule. The hydrophilic radical may be substituted on a terminus of the polymeric organosiloxane, or on any one or more repeating units of the polymer. In general, the repeating dimethylsiloxy units of modified polydimethylsiloxane emulsifiers are lipophilic in nature due to the methyl groups, and confer lipophilicity to the molecule. In addition, longer chain alkyl radicals, hydroxy-polypropyleneoxy radicals, or other types of lipophilic radicals may be substituted onto the siloxy backbone to confer further lipophilicity and organocompatibility. If the lipophilic portion of the molecule is due in whole or part to a specific radical, this lipophilic radical may be substituted on a terminus of the organosilicone polymer, or on any one or more repeating units of the polymer. It should also be understood that the organosiloxane polymer in accordance with the invention should have at least one hydrophilic portion and one lipophilic portion.
- The term “hydrophilic radical” means a radical that, when substituted onto the organosiloxane polymer backbone, confers hydrophilic properties to the substituted portion of the polymer. Examples of radicals that will confer hydrophilicity are hydroxy-polyethyleneoxy, hydroxyl, carboxylates, sulfonates, sulfates, phosphates, or amines.
- The term “lipophilic radical” means an organic radical that, when substituted onto the organosiloxane polymer backbone, confers lipophilic properties to the substituted portion of the polymer. Examples of organic radicals which will conver lipophilicity are C1-40 straight or branched chain alkyl, fluoro, aryl, aryloxy, C1-40 hydrocarbyl acyl, hydroxy-polypropyleneoxy, or mixtures thereof. The C1-40 alkyl may be non-interrupted, or interruped by one or more oxygen atoms, a benzene ring, amides, esters, or other functional groups.
- The polymeric organosiloxane emulsifier used in the invention may have any of the following general formulas:
- M x Q y, or
- M x T y, or
- MD x D′ y D″ z M
- wherein each M is independently a substituted or unsubstituted trimethylsiloxy endcap unit. If substituted, one or more of the hydrogens on the endcap methyl groups are substituted, or one or more methyl groups are substituted with a substituent that is a lipophilic radical, a hydrophilic radical, or mixtures thereof. T is a trifunctional siloxy unit having the empirical formula RSiO15 or RSiO15. Q is a quadrifunctional siloxy unit having the empirical formula SiO2, and D, D′, D″, x, y, and z are as set forth below, with the proviso that the compound contains at least one hydrophilic radical and at least one lipophilic radical. Examples of emulsifiers used in the compositions of the invention are of the general formula:
- MD x D′ y D″ z M
- wherein the trimethylsiloxy endcap unit is unsubstituted or mono-substituted, wherein one methyl group is substituted with a lipophilic radical or a hydrophilic radical. Examples of such substituted trimethylsiloxy endcap units include (CH3)2HPSiO, (CH3)2LPSiO, (CH3)2CH2HPSiO, (CH3)2CH2LPSiO, wherein HP is a hydrophilic radical and LP is a lipophilic radical. D, D′, and D″ are difunctional siloxy units substituted with methyl, hydrogen, a lipophilic radical, a hydrophilic radical or mixtures thereof. In this general formula:
- x=0-5000, preferably 1-1000
- y=0-5000, preferably 1-1000, and
- z=0-5000, preferably 0-1000,
- with the proviso that the compound contains at least one lipophilic radical and at least one hydrophilic radical. Examples of these polymers are disclosed in U.S. Pat. No. 4,698,178, which is hereby incorporated by reference.
- Particularly preferred is a linear silicone of the formula:
- MD x D′ y D″ z M
- wherein M=RRRSiO1/2
- D and D′=RR′SiO2/2
- D″=RRSiO2/2
- x, y, and z are each independently 0-1000,
- where R is methyl or hydrogen, and R′ is a hydrophilic radical or a lipophilic radical, with the proviso that the compound contains at least one hydrophilic radical and at least one lipophilic radical.
- Most preferred is wherein
- M=trimethylsiloxy
- D=Si[(CH3)][(CH2)nCH3]O2/2 where n=1-40,
- D′=Si [(CH3)][(CH2)o—O-PE)]O2/2 where PE is (—C2H4O)a(—C3H6O)bH, o=0-40, a=1-100 and b=1-100, and
- D″=Si (CH3)2O2/2
-
- wherein LP is a lipophilic radical
- HP is a hydrophilic radical
- x is 0-5000
- y is 0-5000, and
- z is 0-5000, with the proviso that the organosiloxane contains at least on hydrophilic radical and at least one lipophilic radical.
-
- wherein p is 1040, preferably 12-20, most preferably 15, and
- PE is (—C2H4O)a(—C3H6O)b—H
- where x, y, z, a, and b are such that the maximum molecular weight of the polymer is approximately 50,000. Organosiloxane polymers useful in the compositions of the invention are commercially available from Goldschmidt Corporation under the ABIL tradename. The preferred polymer is cetyl dimethicone copolyol and has the tradename ABIL WE 09 or ABIL WS 08. The cetyl dimethicone copolyol may be used alone or in conjunction with other non-silicone organic emulsifiers. Preferred is where the cetyl dimethicone copolyol is in an admixture with other non-silicone organic emulsifiers and emollients. In particular, blends of 25-50% of the organosiloxane emulsifier, 25-50% of a non-silicone organic emulsifier, and 25-50% by weight emollients or oils are preferred. For example, the mixtures identified by the C.T.F.A. names cetyl dimethicone copolyol (and) polyglyceryl 4-isostearate (and) hexyl laurate, or cetyl dimethicone copolyol (and) polyglyceryl-3 oleate (and) hexyl laurate both work well. These blends contain approximately 25-50% of each ingredient, for example ABIL WE 09 contains approximately, by weight of the total ABIL composition, 25-50% cetyl dimethicone copolyol, 25-50%, polyglyceryl 4-isostearate, and 25-50% of hexyl laurate which is an emollient or oil.
- Another type of preferred organosiloxane emulsifier suitable for use in the compositions of the invention are emulsifiers sold by Union Carbide under the Silwet™ trademark. These emulsifiers are represented by the following generic formulas:
- (Me3Si)y-2[(OSiMe2)x/yO-PE]y
- wherein PE=—(EO)m(PO)nR
- R=lower alkyl or hydrogen
- Me=methyl
- EO is polyethyleneoxy
- PO is polypropyleneoxy
- m and n are each independently 1-5000
-
- wherein PE=—CH2CH2CH2O(EO)m(PO)nZ
- Z=lower alkyl or hydrogen, and
- Me, m, n, x, y, EO and PO are as described above.
- with the proviso that the molecule contains a lipophilic portion and a hydrophilic portion. Again, the lipophilic portion can be supplied by a sufficient number of methyl groups on the polymer backbone.
-
- Wherein n is 1-10, preferably 8.
- Another preferred organosiloxane emulsifier for use in the compositions of the invention is dimethicone copolyol.
- Examples of other polymeric organosiloxane surfactants or emulsifiers include amino/polyoxyalkyleneated polydiorganosiloxanes disclosed in U.S. Pat. No. 5,147,578. Also suitable are organosiloxanes sold by Goldschmidt under the ABIL trademark including ABIL B-9806, as well as those sold by Rhone-Poulenc under the Alkasil tradename. Also, organosiloxane emulsifiers sold by Amerchol under the Amersil tradename, including Amersil ME-358, Amersil DMC-287 and Amersil DMC-357 are suitable. Dow Corning surfactants such as Dow Corning 3225C Formulation Aid, Dow Corning 190 Surfactant, Dow Corning 193 Surfactant, Dow Corning Q2-5200, and the like are also suitable. In addition, surfactants sold under the tradename Silwet by Union Carbide, and surfactants sold by Troy Corporation under the Troysol tradename, those sold by Taiwan Surfactant Co. under the tradename Ablusoft, those sold by Hoechst under the tradename Arkophob, are also suitable for use in the invention.
- Also suitable as surfactants are various organic surfactants such as anionic, nonionic, amphoteric, zwitterionic, or cationic surfactants.
- The compositions of the invention comprise 0.5-20%, preferably 0.5-15%, more preferably 0.5-10%, of a surfactant. Suitable surfactants may be anionic, nonionic, amphoteric, or zwitterionic.
- Anionic Surfactants
- Anionic surfactants include alkyl and alkyl ether sulfates generally having the formula ROSO3M and RO(C2H4O)xSO3M wherein R is alkyl or alkenyl of from about 10 to 20 carbon atoms, x is 1 to about 10 and M is a water soluble cation such as ammonium, sodium, potassium, or triethanolamine cation.
- Another type of anionic surfactant which may be used in the compositions of the invention are water soluble salts of organic, sulfric acid reaction products of the general formula:
- R1—SO3-M
- wherein R1 is chosen from the group consisting of a straight or branched chain, saturated aliphatic hydrocarbon radical having from about 8 to about 24 carbon atoms, preferably 12 to about 18 carbon atoms; and M is a cation. Examples of such anionic surfactants are salts of organic sulfuric acid reaction products of hydrocarbons such as n-paraffins having 8 to 24 carbon atoms, and a sulfonating agent, such as sulfur trioxide.
- Also suitable as anionic surfactants are reaction products of fatty acids esterified with isethionic acid and neutralized with sodium hydroxide. The fatty acids may be derived from coconut oil, for example.
- In addition, succinates and succinimates are suitable anionic surfactants. This class includes compounds such as disodium N-octadecylsulfosuccinate; tetrasodium N-(1,2-dicarboxyethyl)-N-octadecylsulfosuccinate; and esters of sodium sulfosuccinic acid e.g. the dihexyl ester of sodium sulfosuccinic acid, the dioctyl ester of sodium sulfosuccinic acid, and the like.
- Other suitable anionic surfactants include olefin sulfonates having about 12 to 24 carbon atoms. The term “olefin sulfonate” means a compound that can be produced by sulfonation of an alpha olefin by means of uncomplexed sulfur trioxide, followed by neutralization of the acid reaction mixture in conditions such that any sulfones which have been formed in the reaction are hydrolyzed to give the corresponding hydroxy-alkanesulfonates. The alpha-olefin from which the olefin sulfonate is derived is a mono-olefin having about 12 to 24 carbon atoms, preferably about 14 to 16 carbon atoms.
- Other classes of suitable anionic organic surfactants are the beta-alkoxy alkane sulfonates or water soluble soaps thereof such as the salts of C10-20 fatty acids, for example coconut and allow based soaps. Preferred salts are ammonium, potassium, and sodium salts.
-
- wherein R1 is a C8-24 alkyl or alkenyl radical, preferably C10-18; R2 is H, C1-4 alkyl, phenyl, or —CH2COOM; R3 is CX2— or C1-2 alkoxy, wherein each X independently is H or a C1 alkyl or alkylester, n is from 1 to 4, and M is H or a salt forming cation as described above. Examples of such surfactants are the N-acyl sarcosinates, including lauroyl sarcosinate, myristoyl sarcosinate, cocoyl sarcosinate, and oleoyl sarcosinate, preferably in sodium or potassium forms.
- Nonionic Surfactants
- The composition can contain one or more nonionic surfactants. Nonionic surfactants are generally compounds produced by the condensation of alkylene oxide groups with a hydrophobic compound. Classes of nonionic surfactants are:
- (a) Long chain dialkyl sulfoxides containing one short chain alkyl or hydroxy alkyl radical of from about 1 to 3 carbon atoms and one long hydrophobic chain which may be an alkyl, alkenyl, hydroxyalkyl, or ketoalkyl radical containing from about 8 to 20 carbon atoms, from 0 to 10 ethylene oxide moieties, and 0 or 1 glyceryl moiety.
- (b) Polysorbates, such as sucrose esters of fatty acids. Examples of such materials include sucrose cocoate, sucrose behenate, and so on.
- (c) Polyethylene oxide condensates of alkyl phenols, for example the condensation products of alkyl phenols having an alkyl group of 6 to 20 carbon atoms With ethylene oxide being present in amounts of about 10 to 60 moles of ethylene oxide per mole of alkyl phenol.
- (d) Condensation products of ethylene oxide with the reaction product of propylene oxide and ethylene diamine.
- (e) Condensation products of aliphatic alcohols having 8 to 18 carbon atoms with ethylene oxide, for example a coconut alcohol/ethylene oxide condensate having 10 to 30 moles of ethylene oxide per mole of coconut alcohol, the coconut alcohol fraction having 10 to 14 carbon atoms.
- (f) Long chain tertiary amine oxides such as those corresponding to the general formula:
- R1R2R3NO
- wherein R1 contains an alkyl, alkenyl or monohydroxyalkyl radical ranging from about 8 to 18 carbon atoms in length, from 0 to about 10 ethylene oxide moieties, and from 0 to about 1 glyceryl moiety and R2 and R3 are each alkyl or monohydroxyalkyl groups containing from about 1 to about 3 carbon atoms.
- (g) Long chain tertiary phosphine oxides corresponding to the general formula:
- RR1 R2PO
- wherein R contains an alkyl, alkenyl, or monohydroxyalkyl radical having 8 to 18 carbon atoms, from 0-10 ethylene oxide moieties and 0 or 1 glyceryl moiety, and R2 and R3 are each alkyl or monohydroxyalkyl group containing from about 1 to 3 carbon atoms.
- (h) Alkyl polysaccharides having a hydrophobic group of 6 to 30, preferably 10, carbon atoms and a polysaccharide group such as glucose, galactose, etc. Suitable alkyl polysaccharides are octyl, nonydecyl, undecyldodecyl, tridecyl, tetradecyl, pentadecyl, hexadecyl, heptadecyl, and octadecyl, di-, tri-, tetra-, penta-, and hexaglucosides, galactosides, lactosides, giucoses, fructosides, fructoses, and so on.
- (i) Polyethylene glycol (PEG) glyceryl fatty esters, having the formula
- RC(O)OCH2CH(OH)CH2(OCH2CH2)nOH
- wherein n is 5-200 and RC(O) is a hydrocarbylcarbonyl group wherein R is preferably an aliphatic radical having 7 to 19 carbon atoms.
- (j) Other nonionic surfactants that may be used include C10-18 alkyl(C1-6)polyhydroxy fatty acid amides such as C12-18 methylglucamides, N-alkoxy polyhydroxy fatty acid amides, N-propyl through N-hexyl C12-19 glucamides and so on.
- Amphoteric Surfactants
- Amphoteric surfactants that can be used in the compositions of the invention are generally described as derivatives of aliphatic secondary or tertiary amines wherein one aliphatic radical is a straight or branched chain alkyl of 8 to 18 carbon atoms and the other aliphatic radical contains an anionic group such as carboxy, sulfonate, sulfate, phosphate, or phosphonate.
-
- wherein R1 is C8-22 alkyl or alkenyl, preferably C12-16; R2 is hydrogen or CH2CO2M, R3 is CH2CH2OH or CH2CH2OCH2CHCOOM; R4 is hydrogen, CH2CH2OH, or CH2CH2OCH2CH2COOM, Z is CO2M or CH2CO2M, n is 2 or 3, preferably 2, M is hydrogen or a cation such as an alkali metal, alkaline earth metal, ammonium, or alkanol ammonium. cation. Examples of such materials are marketed under the tradename MIRANOL, by Miranol, Inc.
- Also suitable amphoteric surfactants are monocarboxylates or dicarboxylates such as cocamphocarboxypropionate, cocoamphocarboxypropionic acid, cocamphocarboxyglycinate, and cocoamphoacetate.
- Other types of amphoteric surfactants include aminoalkanoates of the formula
- R—NH(CH2)nCOOM
- or iminodialkanoates of the formula:
- R—N[(CH2)mCOOM]2
- and mixtures thereof; wherein n and m are 1 to 4, R is C8-22 alkyl or alkenyl, and M is hydrogen, alkali metal, alkaline earth metal, ammonium or alkanolammonium. Examples of such amphoteric surfactants include n-alkylaminopropionates and n-alkyliminodipropionates, which are sold under the trade name MIRATAINE by Miranol, Inc. or DERIPHAT by Henkel, for example N-lauryl-beta-amino propionic acid, N-lauryl-beta-imino-dipropionic acid, or mixtures thereof.
-
- wherein R2 contains an alky, alkenyl or hydroxy alkyl radical of from about 8 to about 18 carbon atoms, from 0 to about 10 ethylene oxide moieties and 0 or I glyceryl moiety; Y is selected from the group consisting of nitrogen, phosphorus, and sulfur atoms; R3 is an alkyl or monohydroxyalkyl group containing about 1 to 3 carbon atoms; X is 1 when Y is a sulfur atom, and 2 when Y is a nitrogen or phosphorus atom; R4 is an alkylene or hydroxyalkylene of from about 1 to about 4 carbon atoms, and Z is a radical selected from the group consisting of carboxylate, sulfonate, sulfate, phosphonate, and phosphate groups.
- Zwitterionics include betaines, for example higher alkyl betaines such as coco dimethyl carboxymethyl betaine, lauryl dimethyl carboxymethyl betaine, lauryl dimethyl alphacarboxyethyl betaine, cetyl dimethyl carboxymethyl betaine, lauryl bis-(2-hydroxyethyl)carboxymethyl betaine, stearyl bis-(2-hydroxypropyl)carboxymethyl betaine, oleyl dimethyl gamma-carboxylethyl betaine, and mixtures thereof. Also suitable are sulfo- and amido-betaines such as coco dimethyl sulfopropyl betaine, stearyl dimethyl sulfopropyl betaine, and the like.
- Cationic surfactants and/or polymers may be incorporated into the compositions of the invention. If so, 0.01-15%, preferably 0.05-10%, preferably 0.10-8% of a cationic ingredients is suggested. Suitable cationic ingredients include cationic polymers, quaternary ammonium salts, or the salts of fatty amines. Quaternary ammonium salts have the formula:
- wherein R1 is hydrogen, an aliphatic group of 1 to 22 carbon atoms, or aromatic, aryl, or alkaryl group having 12 to 22 carbon atoms; R2 is an aliphatic group having 1-22 carbon atoms; R3 and R4 are each alkyl groups of from 1 to 3 carbon atoms, and X is an anion selected from halogen, acetate, phosphate, nitrate and methyl sulfate radicals. The aliphatic groups may contain, in addition to carbon and hydrogen atoms, ether linkages as well as amido groups.
- Suitable quaternary ammonium compounds may be mono-long chain alkyl, di-long chain alkyl, tri-long chain alkyl, and the like. Examples of such quaternary ammonium salts include behenalkonium chloride, behentrimonium chloride, behentrimonium methosulfate, benzalkonium chloride, benzethonium chloride, benzyl triethyl ammonium chloride, cetalkonium chloride, cetrimonium chloride, cetrimonium bromide, cetrimonium methosulfate, cetrimonium tosylate, cetylpyridinium chloride, dibehenyudiarachidyl dimonium chloride. dibehenyldimonium chloride, dibehenyldimonium methosulfate, dicapryl/dicaprylyl dimonium chloride, dicetyldimonium chloride, and mixtures thereof.
-
- wherein R1 is an aliphatic group having 16 to 22 carbon atoms, R2, R3, R4, R5, and R6 are the same or different and are selected from H and alkyls having 1 to 4 carbon atoms and X is an anion as above defined.
-
- wherein R5 is hydrogen or a C1-4 alkyl; R6 is a C1-4 alkyl; R7 is a C8-22 alkyl; and R8 is hydrogen, or a C1-22 alkyl; and X is an anion as defined above.
- Also suitable as the cationic surfactant are salts of fatty primary, secondary, or tertiary amines, wherein the substituted groups have 12 to 22 carbon atoms. Examples of such amines include dimethyl stearamine, dimethyl soyamine, stearylamine, myristylamine, tridecylamine, ethyl stearamine, and so on.
- Also suitable as the cationic ingredient are cationic polymers such as:
- (a) Quaternary derivatives of cellulose ethers such as polymers sold under the tradename JR-125, JR-400, JR-30M. Preferred is Polyquaternium 10, which is a polymeric quaternary ammonium salt of hydroxyethyl cellulose reacted with a trimethyl ammonium subsituted epoxide.
-
- wherein R is hydrogen or methyl, preferably methyl;
- y is 0 or 1, preferably 1
- R2 is O or NH, preferably NH;
- R3 is CxH2x where x is 2 to 18, or —CH2—CHOH—CH—, preferably CxH2x where x is 2;
- R4 is methyl, ethyl, phenyl, or C1-4 substituted phenyl, preferably methyl; and
- R5 is methyl or ethyl, preferably methyl.
- (c) Homopolymer of dimethyldiallylammonium chloride, or copolymer of dimethyldiallylammonium chloride and acrylamide. Such compounds are sold under the tradename MERQUAT™ by Merck and Company.
- (d) Homopolymers or copolymers derived from acrylic or methacrylic acid wherein the monomer units are selected from the group consisting of acrylamide, methylacrylamide, diacetone-acrylamide, acrylamide or methacrylamide substituted on the nitrogen by lower alkyl, alkyl esters of acrylic acid and methacrylic acid, vinylpyrrolidone, and vinyl esters.
- Examples of cationic polymers that can be used in the compositions of the invention are the cationic polymers disclosed in U.S. Pat. Nos. 5,240,450 and 5,573,709, which are hereby incorporated by reference.
- Waxes
- The compositions of the invention may contain 0.1-25%, preferably 0.5-20%, more preferably 1-15% by weight of the total composition of wax. Suitable waxes have a melting point of 35 to 120° C., and can be animal waxes, plant waxes, mineral waxes, silicone waxes, synthetic waxes, and petroleum waxes. Examples of waxes in accordance with the invention include bayberry, beeswax, candelilla, carnauba, ceresin, cetyl esters, hydrogenated jojoba oil, hydrogenated jojoba wax, hydrogenated microcrystalline wax, hydrogenated rice bran wax, japan wax, jojoba butter, jojoba esters, jojoba wax, lanolin wax, microcrystalline wax, mink wax, montan acid wax, montan wax, ouricury wax, ozokerite, paraffin, PEG-6 beeswax, PEG-8 beeswax, rice bran wax, shellac wax, spent grain wax, sulfurized jojoba oil, synthetic beeswax, synthetic candelilla wax, synthetic carnauba wax, synthetic japan wax, synthetic jojoba oil, ethylene homo- or copolymers, stearoxy dimethicone, dimethicone behenate, stearyl dimethicone, and the like, as well synthetic homo- and copolymer waxes such as PVP/eicosene copolymer, PVP/hexadecene copolymer, and the like.
- Branched Chain Silicone Resins
- It may be desireable to include one or more branched chain silicone resins in the compositions of the invention. If so, a range of 0.001-20%, preferably 0.01-15%, more preferably 0.1-10%0/by weight of the total composition is suggested. Examples of suitable silicone resins include siloxy silicate polymers having the following general formula:
- [(RR′R″)3SiO1/2]x[SiO2]y
- wherein R, R′ and R″ are each independently a C1-10 straight or branched chain alkyl or phenyl, and x and y are such that the ratio of (RR′R″)3SiO1/2 units to SiO2 units is 0.5 to 1 to 1.5 to 1.
- Preferably R, R′ and R″ are a C1-6 alkyl, and more preferably are methyl and x and y are such that the ratio of (CH3)3SiO1/2 units to SiO2 units is 0.75 to 1. Most preferred is this trimethylsiloxy silicate containing 2.4 to 2.9 weight percent hydroxyl groups which is formed by the reaction of the sodium salt of silicic acid, chlorotrimethylsilane, and isopropyl alcohol. The manufacture of trimethylsiloxy silicate is set forth in U.S. Pat. Nos. 2,676,182; 3,541,205; and 3,836,437, all of which are hereby incorporated by reference. Trimethylsiloxy silicate as described is available from Dow Corning Corporation under the tradename 2-0749 and 2-0747, which is a blend of about 40-60% volatile silicone and 40-60% trimethylsiloxy silicate. Dow Corning 2-0749 in particular, is a fluid containing about 50% trimethylsiloxy silicate and about 50% cyclomethicone. The fluid has a viscosity of 200-700 centipoise at 25° C., a specific gravity of 1.00 to 1.10 at 25° C., and a refractive index of 1.40-1.41.
- Other branched chain silicone resins are silicone esters comprising units of the general formula RaRE bSiO[4−(a+b)/2] or R13 xRE ySiO1/2, wherein R and R13 are each independently an organic radical such as alkyl, cycloalkyl, or aryl, or, for example, methyl, ethyl, propyl, hexyl, octyl, decyl, aryl, cyclohexyl, and the like. a is an number ranging from 0 to 3, b is a number ranging from 0 to 3, a+b is a number ranging from 1 to 3, x is a number from 0 to 3, y is a number from 0 to 3 and the sum of x+y is 3, and wherein RE is a carboxylic ester containing radical. Preferred RE radicals are those wherein the ester group is formed of one or more fatty acid moieities (e.g. of about 6, often about 6 to 30 carbon atoms) and one or more aliphatic alcohol moieities (e.g. of about 10 to 30 carbon atoms). Examples of such acid moieities include those derived from branched-chain fatty acids such as isostearic, or straight chain fatty acids such as behenic. Examples of suitable alcohol moieties include those derived from monohydric or polyhydric alcohols, e.g. normal alkanols such as n-propanol and branched-chain etheralkanols such as (3,3,3-trimethylolpropoxypropane. Preferably the ester subgroup (i.e. the group containing the carboxylic ester) will be linked to the silicon atom by a divalent aliphatic chain that is at least 2 or 3 carbon atoms in length, e.g. an alkylene group or a divalent alkyl ether group. Most preferably that chain will be part of the alcohol moiety, not the acid moiety. More particularly, the cross-linked silicone ester can be a liquid or solid at room temperature. Preferably it will have a waxy feel and a molecular weight of no more than about 100,000 daltons.
- Such silicone resins having the above formula are disclosed in U.S. Pat. No. 4,725,658 and U.S. Pat. No. 5,334,737, which are hereby incorporated by reference. These ingredients are commercially available from General Electric under the tradenames SF 1318 and SF 1312, respectively.
- Pigments and Powders
- The composition of the invention may contain 0.001-35%, preferably 0.01-20% more preferably 0.1-10%, by weight of the total composition, of dry particulate matter having a particle size of 0.02 to 200, preferably 0.5 to 100, microns. The particulate matter may be colored or non-colored (for example white). Suitable powders include bismuth oxychloride, titanated mica, fumed silica, spherical silica, polymethylmethacrylate, micronized teflon, boron nitride, acrylate copolymers, aluminum silicate, aluminum starch octenylsuccinate, bentonite, calcium silicate, cellulose, chalk, corn starch, diatomaceous earth, fuller's earth, glyceryl starch, hectorite, hydrated silica, kaolin, magnesium aluminum silicate, magnesium trisilicate, maltodextrin, montmorillonite, microcrystalline cellulose, rice starch, silica, talc, mica, titanium dioxide, zinc laurate, zinc myristate, zinc rosinate, alumina, attapulgite, calcium carbonate, calcium silicate, dextran, kaolin, nylon, silica silylate, silk powder, sericite, soy flour, tin oxide, titanium hydroxide, trimagnesium phosphate, walnut shell powder, or mixtures thereof. The above mentioned powders may be surface treated with lecithin, amino acids, mineral oil, silicone oil or various other agents either alone or in combination, which coat the powder surface and render the particles more lipophilic in nature.
- The powder component also may comprise various organic and inorganic pigments. The organic pigments are generally various aromatic types including azo, indigoid, triphenylmethane, anthraquinone, and xanthine dyes which are designated as D&C and FD&C blues, browns, greens, oranges, reds, yellows, etc. Organic pigments generally consist of insoluble metallic salts of certified color additives, referred to as the Lakes. Inorganic pigments include iron oxides, ultramarines, chromium, chromium hydroxide colors, and mixtures thereof.
- The composition may contain a mixture of both pigmented and non-pigmented powders. The percentage of pigments used in the powder component will depend on the type of cosmetic being formulated.
- Sunscreens
- The compositions of the invention may contain 0.001-20%, preferably 0.01-10%, more preferably 0.05-8% of one or more sunscreens. A sunscreen is defined as an ingredient that absorbs at least 85 percent of the light in the UV range at wavelengths from 290 to 320 nanometers, but transmit UV light at wavelengths longer than 320 nanometers. Sunscreens generally work in one of two ways. Particulate materials, such as zinc oxide or titanium dioxide, as mentioned above, physically block ultraviolet radiation. Chemical sunscreens, on the other hand, operate by chemically reacting upon exposure to UV radiation. Suitable sunscreens that may be included in the compositions of the invention are set forth on page 582 of theCTFA Cosmetic Ingredient Handbook, Second Edition, 1992, as well as U.S. Pat. No. 5,620,965, both of which are hereby incorpated by reference. Examples of such sunscreen materials are p-aminobenzoic acid (PABA), cinoxate, diethanolamine p-methoxycinnamate (DEA-methoxycinnamate), Digalloyl trioleate, dioxybenzone (Benzophenone-8), ethyl 4-[bis-(hydroxypropyl)] amnobenzoate (ethyl dihydroxypropyl PABA), 2-ethythexyl-2-cyano-3,3-diphenylacrylate (octocrylene), ethylhexyl p-methoxycinnamate (Octyl methoxycinnamate), 2-ethylhexyl salicylate (Octyl salicylate), glyceryl aminobenzoate (Glyceryl PABA), homosalate, lawsone with dihydroxyacetone, menthyl anthranilate, oxybenzone (Benzophenone-3), Padimate A (Pentyl Dimethyl PABA), Padimate 0, (Octyl Dimethyl PABA), 2-Phenylbenzimidazole-5-sulfonic acid (Phenylbenzimidazole Sulfonic acid), Red Petrolatum, Sulisobenzone (Benzophenone4), triethanolamine salicylate (TEA-Salicylates), and so on.
- Preservatives
- The composition may contain 0.0001-8%, preferably 0.001-6%, more preferably 0.005-5% by weight of the total composition of preservatives. A variety of preservatives are suitable, including such as benzoic acid, benzyl alcohol, benzylhemiformal, benzylparaben, 5-bromo-5-nitro-1,3-dioxane, 2-bromo-2-nitropropane-1,3-diol, butyl paraben, calcium benzoate, calcium propionate, captan, chlorhexidine diacetate, chlorhexidine digluconate, chlorhexidine dihydrochloride, chloroacetamide, chlorobutanol, p-chloro-m-cresol, chlorophene, chlorothymol, chloroxylenol, m cresol, o-cresol, DEDM Hydantoin, DEDM Hydantoin dilaurate, dehydroacetic acid, diazolidinyl urea, dibromopropamidine diisethionate, DMDM Hydantoin, and all of those disclosed on pages 570 to 571 of the CTFA Cosmetic Ingredient Handbook, Second Edition, 1992, which is hereby incorporated by reference.
- Vitamins and Antioxidants
- The compositions of the invention may contain vitamins and/or coenzymes, as well as antioxidants. If so, 0.001-10%, preferably 0.01-8%, more preferably 0.05-5% by weight of the total composition are suggested. Suitable vitamins include the B vitamins such as thiamine, riboflavin, pyridoxin, and so on, as well as coenzymes such as thiamine pyrophoshate, flavin adenin dinucleotide, folic acid, pyridoxal phosphate, tetrahydrofolic acid, and so on. Also Vitamin A and derivatives thereof are suitable. Examples are Vitamin A palmitate, acetate, or other esters thereof, as well as Vitamin A in the form of beta carotene. Also suitable is Vitamin E and derivatives thereof such as Vitamin E acetate, nicotinate, or other esters thereof. In addition, Vitamins D and K are suitable.
- Suitable antioxidants are ingredients which assist in preventing or retarding spoilage. Examples of antioxidants suitable for use in the compositions of the invention are potassium sulfite, sodium bisulfite, sodium erythrobate, sodium metabisulfite, sodium sulfite, propyl gallate, cysteine hydrochloride, butylated hydroxytoluene, butylated hydroxyanisole, and so on.
- Alpha or Beta Hydroxy Acids, Alpha Keto Acids
- It may be desired to add one or more alpha or beta hydroxy acids or alpha ketoacids to the compositions of the invention. Suggested ranges are 0.01-20%, preferably 0.1-15%, more preferably 0.5-10% by weight of the total composition. Suitable alpha hydroxy acids and alpha ketoacids are disclosed in U.S. Pat. No. 5,091,171, which is hereby incorporated by reference. Such alpha hydroxy acids are as follows:
- a) Organic carboxylic acids where one hydroxyl group is attached to the alpha carbon atom of the acid. The general structure of such alpha hydroxy acids may be represented by the following formula:
- (Ra)(Rb)C(OH)COOH
- wherein Ra and Rb are H, F, Cl, Br, alkyl, aralkyl, or aryl group of saturated, unsaturated, straight or branched chain or cyclic form having 1-10 carbon atoms, and in addition Ra or Rb may carry OH, CHO, COOH and alkoxy groups having 1 to 9 carbon atoms.
- The second group of alpha hydroxy acids may be represented by the following formula:
- (Ra)CO COO(Rb)
- wherein Ra and Rb are H, alkyl, aralkyl, or aryl groups of straight or branched chain saturated or unsaturated alkyl having 1 to 10 carbon atoms, and in addition Ra may carry F, Cl, Br, I, OH, CHO, COOH, and alkoxy groups having 1 to 10 carbon atoms.
- The alpha hydroxy acids may exist in the keto acid form, or the ester form. Examples of such alpha hydroxy acids include glycolic acid, malic acid, pyruvic acid, mandelic acid, lactic acid, methyllactic acid, and so on.
- Also beta hydroxy acids such as salicylic acid, and derivatives thereof may be included in the compositions of the invention.
- The Method
- The anhydrous emulsions of the invention are made by first subjecting the nonaqueous polar organic solvent to an input of energy, preferably heat energy. In particular, the nonaqueous polar organic solvent is heated to a temperature sufficient to dissolve the ascorbic acid. A temperature above room temperature is generally required to achieve solubilization of ascorbic acid to any appreciable degree. Preferably, the nonaqueous polar organic solvent is heated to a temperature of about 70 to 170, more preferably about 80 to 120, more preferably about 90-110, and most preferably about 95-105° C. The heat energy required may depend on conditions such as the pressure at which the nonaqueous polar organic solvent is maintained. For example, if the pressure of the nonaqueous polar organic solvent is increased above standard pressure at room temperature, the temperature required to dissolve appreciable levels of ascorbic acid in the solvent is correspondingly less. Conversely, if the nonaqueous polar organic solvent is maintained at a pressure which is less than the standard pressure at room temperature, the temperature required to dissolve appreciable levels of ascorbic acid may be correspondingly greater. The energy source may be standard heat as well as heat radiation from sources such as long and short microwaves, infrared radiation, sonication, microfluidization, and the like.
- While maintaining the temperature, the ascorbic acid is added to the nonaqueous polar organic solvent with stirring until dissolved. The temperature of the mixture is then reduced, i.e. the mixture is cooled, by reducing the temperature by 10 to 145° C., more preferably by 20 to 100° C., most preferably by 40 to 95° C. Most preferably the mixture is cooled to room temperature. It is preferred to cool the mixture to room temperature quickly, for example by plunging a container of the mixture into an ice water bath until the mixture attains room temperature.
- In the preferred embodiment of the invention, one of the nonaqueous polar organic solvents is heated in a vessel to about 100° C. The ascorbic acid is added with stirring until dissolved. The vessel containing the mixture is then plunged into an ice water bath and held there until it has cooled to room temperature. Then, the mixture is reheated to a temperature of 70-170°, 80-110°, preferably 95-105°, more preferably about 100° C. and the second nonaqueous polar organic solvent is added with stirring. The mixture is then rapidly cooled to room temperature by putting it into an ice water bath.
- It has been discovered that the rapid cooling appears to promote solubilization of the ascorbic acid into the nonaqueous polar organic solvent. In addition, adding the nonaqueous polar organic solvents one at a time followed by rapid cooling, promotes the highest level of stability and solubility of ascorbic acid in the nonaqueous polar organic solvent. Most unexpectedly, concentrations of solubilized ascorbic acid up to 25% have been achieved using solvents which normally provide very low solubility of ascorbic acid.
- The ascorbic acid solubilized in the nonaqueous polar organic solvent is emulsified into the nonaqueous nonpolar organic solvent at room temperature by homogenizing by using standard homogenizing equipment such as the Eppenbach Homo-mixer. In the case where the ascorbic acid dissolved in the nonaqueous polar organic solvent forms the continuous phase, the nonaqueous nonpolar organic solvent is emulsified into the ascorbic acid mixture at room temperature using homogenization.
- An anhydrous emulsion suitable as a skin lotion, was made in accordance with the invention as follows:
w/w % Cetyl dimethicone copolyol 3.00 (surfactant) Hydrogenated castor oil 5.00 (wax) Polyethylene 1.00 (wax) Polyglyceryl-4-isostearate 1.50 (surfactant) Polyethylene/mineral oil 15.00 (wax/nonpolar organic solvent) (6:94) Cyclomethicone 12.00 (nonpolar organic solvent) C12-15 alkyl benzoate 12.50 (nonpolar organic solvent) Glycerine 33.40 (polar organic solvent) PEG-6 6.70 (polar organic solvent) Ascorbic acid 10.00 - The glycerine was heated to a temperature of 100° C. The ascorbic acid was added to the glycerine while maintaining the temperature at 100° C., while stirring until dissolved. The solution was then put into an ice water bath until the mixture cooled to room temperature. The mixture was a clear solution. The mixture was then heated back up to 100° C., and the PEG-6 was added to the hot mixture with stirring. The mixture was then put into an ice water bath again until cooled to room temperature.
- The remaining ingredients were separately mixed, yielding a nonpolar solvent phase, and the ascorbic acid/glycerine/PEG-6 mixture was dispersed into the nonpolar solvent phase by homogenizing using an Eppenbach Homo-mixer.
- An anhydrous emulsion suitable for use as a skin lotion was made as follows:
w/w % Dimethicone copolyol/cyclomethicone 10.50 (surfactant/nonpolar (10:90) organic solvent) Cetyl dimethicone copolyol 1.00 (surfactant) Trihydroxystearin/cyclomethicone 9.50 (nonpolar organic (17.5:82.5) solvent/nonpolar organic solvent) Dimethiconol/cyclomethicone 2.00 (surfactant/nonpolar (13:87) organic solvent) PEG-6 31.00 (polar organic solvent) Glycerin 35.40 (polar organic solvent) Ascorbic acid 10.60 - The glycerin was heated to a temperature of 100° C. The ascorbic acid was added to the heated mixture while maintaining the temperature at 100° C., and stirring until dissolved. The mixture was then put into an ice water bath until the mixture cooled to room temperature. The mixture was then heated back up to 100° C., and the PEG-6 was added to the hot mixture with stirring. The mixture was then put into an ice water bath until cooled to room temperature.
- The remaining ingredients were separately mixed, and the ascorbic acid/glycerine/PEG-6 mixture was dispersed into the nonpolar phase by homogenizing.
- Anhydrous emulsions suitable for use as a skin treatment lotion and cream were prepared as follows:
1 2 Ascorbic acid 10.00 10.00 PEG-6 (nonaqueous polar organic solvent) 33.7 6.7 Glycerine (nonaqueous polar organic solvent) 33.3 33.3 Octyl methoxycinnamate (sunscreen) 7.5 — Safflower oil (nonaqueous nonpolar organic solvent) 7.5 — Tocopheryl acetate (vitamin) 1.0 — Polyacrylamide/C13-14 isoparaffin/laureth-7 1.0 — Sorbitan oleate (surfactant) 2.7 — Polysorbate 80 (nonaqueous polar organic solvent) 3.3 — Steareth-21 (surfactant) — 12.0 Steareth-2 (surfactant) — 4.0 Polysorbate 20 (nonaqueous polar organic solvent) — 1.0 Glyceryl stearate (nonaqueous nonpolar organic solvent) — 8.0 Cetyl alcohol (nonaqueous nonpolar organic solvent) — 4.0 C12-15 alkyl benzoate — 16.6 Preservatives — 0.4 - The glycerine was heated to a temperature of 100° C. The ascorbic acid was added to the heated mixture while maintaining the temperature at 100° C. and stirring until dissolved. The mixture was then put into an ice water bath until the mixture cooled to room temperature. The mixture was then heated back up to 100° C., and the PEG-6 was added to the hot mixture with stirring. The mixture was then put into an ice water bath until cooled to room temperature.
- The remaining ingredients were separately mixed, and dispersed into the ascorbic acid/glycerine/PEG-6 mixture by homogenizing. Sample 1 provided a pourable translucent gel-like emulsion. Sample 2 provided a non-pourable opaque cream.
- The solubility of ascorbic acid in various solvents was correlated with the octanol/water partition coefficient of the solvent. The partition coefficient of each solvent was measured using a software program marketed by Advanced Chemistry Development, Inc., called the ACD/LogP program, which calculates the partition coefficient from the molecular structure of the solvent. The solubility of the ascorbic acid was determined by heating the solvent to a temperature in excess of 100° C., preferably in the range of 105 to 110° C. while monitoring with a thermometer. Measured amounts (in weight percent, i.e. 1%, 2%, 3%, 4%, 5%, up to 20%, 25%, etc.) of ascorbic acid were added to separate tubes containing the hot solvent while mixing. After the ascorbic acid dissolved, the samples were cooled to room temperature. The solubility of ascorbic acid in the particular solvent was the maximum weight percent of ascorbic acid that could be solubilized in the solvent before the solution turned cloudy and crystal formation occurred at room temperature after one month. In other words, the solubility was determined to be the maximum weight percent of ascorbic acid that could be solubilized in the solvent, where the solution remained clear and no microscopic evidence of crystal formation was evident at room temperature after one month.
- The results are set forth below:
Solvent Ascorbic Acid Solubility wt % LogP Ethylene glycol 25 −1.69 1,2-propanediol 17 −1.34 1,2-butanediol 9 −0.81 1,2-pentanediol 3 −0.28 1,2-hexanediol 1 0.25 Diethylene glycol 21 −1.51 Triethylene glycol 17 −1.50 Glycerine 17 −2.41 Polyethylene glycol 300 8 −1.46 Polyethylene glycol 400 7 −1.43 Polyethylene glycol 600 5 −1.39 Dipropylene glycol 9 −0.82 Polypropylene glycol n = 6 3 0.97 Polyglycol EP530 0.1 9.25 Synalox PB-200 fluid (n = 14) 0.5 5.79 Glyceryl monooleate 0.1 6.91 Glyceryl stearate 0.1 7.43 Diglycerol 18 −2.86 - The solvents which exhibit octanol/water partition coefficients of less than −0.2 may be used as the nonaqueous polar organic solvent. The solvents which exhibit octanol/water partition coefficients of greater than −0.2 may be used as the nonaqueous nonpolar organic solvent.
- Stability studies were performed on the formula of Example 2, containing 10.6% ascorbic acid, as follows:
Time Temperature % Ascorbic Acid Remaining 5 months 25° C. 9.6% 5 months 40° C. 9.6% 5 months 50° C. 6.6% - It can be seen that the ascorbic acid in the formula of Example 2 exhibits good stability at room temperature and at elevated temperatures.
- While the invention has been described in connection with the preferred embodiment, it is not intended to limit the scope of the invention to the particular form set forth, but, on the contrary, it is intended to cover such alternatives, modifications and equivalents as may be included within the spirit and scope of the invention as defined by the appended claims.
Claims (30)
1. A composition in the form of an anhydrous emulsion having as a dispersed phase ascorbic acid dissolved by means of energy input, in a nonaqueous polar organic solvent, and as the continuous phase a nonaqueous nonpolar organic solvent.
2. The composition of claim 1 which is a cosmetic composition.
3. The composition of claim 1 comprising, by weight of the total composition:
0.1-50% ascorbic acid.
5-98% of a nonaqueous polar organic solvent, and
5-98% of a nonaqueous nonpolar organic solvent.
4. The composition of claim 1 wherein the ascorbic acid is completely dissolved in the nonaqueous polar organic solvent.
5. The composition of claim 1 comprising 5-35% by weight of ascorbic acid.
6. The composition of claim 5 comprising 8-15% by weight of ascorbic acid.
7. The composition of claim 1 comprising 1-35% ascorbic acid, 20-80% of a nonaqueous polar organic solvent, and 20-80% of a nonaqueous nonpolar organic solvent.
8. The composition of claim 1 wherein the nonaqueous polar organic solvent has an octanol/water partition coefficient of less than or equal to −0.2 at 250 C.
9. The composition of claim 8 wherein the nonaqueous polar solvent is selected from the group consisting of:
a) polyols having three or more hydroxyl groups per molecule,
b) monomeric or polymeric ethers,
c) alcohols of the formula R(OH)n
d) diols
e) sorbitan derivatives,
f) and mixtures thereof.
10. The composition of claim 1 wherein the nonaqueous nonpolar organic solvent has an octanol/water partition coefficient of greater than −0.2 at 25° C.
11. The composition of claim 10 wherein the nonaqueous nonpolar organic solvent is selected from the group consisting of:
a) silicones,
b) fatty esters,
c) glyceryl esters of fatty acids.
d) fatty acids,
e) fatty alcohols,
f) hydrocarbons,
g) lanolin and derivatives thereof,
h) sterols, and
i) mixtures thereof.
12. The composition of claim 9 wherein the nonaqueous polar solvent is selected from the group consisting of polyols having three or more carbon atoms, monomeric or polymeric ethers, and mixtures thereof.
13. The composition of claim 11 wherein the nonaqueous nonpolar solvent is selected from the group consisting of silicones, fatty esters, hydrocarbons, and mixtures thereof.
14. A method for dissolving ascorbic acid in a nonaqueous polar organic solvent, comprising the steps of:
a) heating the nonaqueous polar organic solvent to a temperature sufficient to dissolve ascorbic acid in the nonaqueous polar organic solvent.
b) dissolving particulate ascorbic acid in the heated carrier composition, and
c) cooling the mixture.
15. The method of claim 14 wherein the nonaqueous polar organic solvent is heated to a temperature of 70 to 170° C.
16. The method of claim 15 wherein the temperature of the mixture is cooled by reducing the temperature by 10 to 145° C.
17. The method of claim 15 wherein the mixture is cooled to room temperature.
18. The method of claim 15 wherein after cooling the mixture, it is reheated to a temperature of 70 to 170° C. and a second nonaqueous polar organic solvent is added.
19. The method of claim 18 wherein after the addition of the second nonaqueous polar organic solvent, the mixture is cooled.
20. The method of claim 19 wherein the mixture is cooled to room temperature.
21. The method of claim 20 wherein the mixture is cooled to room temperature by immersing in an ice water bath.
22. A method for dissolving ascorbic acid in nonaqueous polar organic solvent comprising the steps of:
a) heating a first nonaqueous polar organic solvent to a temperature of 70 to 1700 C.,
b) dissolving ascorbic acid in the first solvent,
c) cooling the mixture,
d) reheating the mixture to a temperature of 70 to 170° C.
e) adding a second nonaqueous polar organic solvent,
f) cooling the mixture.
22. The method of claim 21 wherein the composition is cooled to room temperature.
23. The method of claim 21 wherein the first nonaqueous polar organic solvent is a polyol having three or more carbon atoms.
24. The method of claim 21 wherein the second nonaqueous polar organic solvent is a polymeric ether.
25. A cosmetic composition in the form of an anhydrous emulsion having as the dispersed phase a nonaqueous nonpolar organic solvent, and as the continuous phase ascorbic acid dissolved in a nonaqueous polar organic solvent, said composition comprising, by weight of the total composition:
0.1-50% ascorbic acid,
5-98% of a nonaqueous polar organic solvent, and
5-98% of a nonaqueous nonpolar organic solvent.
26. A method for making an anhydrous emulsion having as a dispersed phase ascorbic acid dissolved in a nonaqueous polar organic solvent, and as the continuous phase a nonaqueous nonpolar organic solvent, said composition comprising, by weight of the total composition:
0.1-40% ascorbic acid,
5-98% of a nonaqueous polar organic solvent,
5-98% of a nonaqueous nonpolar organic solvent,
comprising the steps of:
a) heating the nonaqueous polar organic solvent to a temperature of about 80 to 120° C.,
b) dissolving particulate ascorbic acid in the heated carrier composition,
c) cooling the mixture.
27. The method of claim 26 wherein the mixture is then emulsified into the nonaqueous nonpolar organic solvent.
28. A method for making an anhydrous emulsion having as the dispersed phase a nonaqueous nonpolar organic solvent, and as the continuous phase ascorbic acid dissolved in a nonaqueous polar organic solvent, said composition comprising, by weight of the total composition:
0.1-40% ascorbic acid,
5-98% of a nonaqueous polar organic solvent, and
5-98% of a nonaqueous nonpolar organic solvent,
comprising the steps of:
a) heating the nonaqueous nonpolar organic solvent to a temperature of 80 to 120° C.
b) dissolving particulate ascorbic acid in the heated composition of (a),
c) cooling the mixture.
29. The method of claim 28 wherein the nonaqueous nonpolar organic solvent is emulsified into the mixture nonaqueous polar organic solvent containing dissolved ascorbic acid.
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Publication number | Priority date | Publication date | Assignee | Title |
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US20090005285A1 (en) * | 2000-06-05 | 2009-01-01 | Anna Vadimovna Noyes | Composition For Treating Or Cleaning Fabrics |
US7704937B2 (en) * | 2000-06-05 | 2010-04-27 | The Procter & Gamble Company | Composition comprising an organosilicone/diol lipophilic fluid for treating or cleaning fabrics |
US20060280711A1 (en) * | 2005-06-14 | 2006-12-14 | L'oreal | Process for treating marionette lines |
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US8865228B2 (en) | 2006-02-21 | 2014-10-21 | Mary Kay Inc. | Stable vitamin C compositions |
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US11771638B2 (en) | 2006-02-21 | 2023-10-03 | Mary Kay Inc. | Stable vitamin C compositions |
US20110184006A1 (en) * | 2010-01-28 | 2011-07-28 | National Research Council Of Sri Lanka | Method and composition for thermally stabilizing vitamin c within nano layers of montmorillonite clay |
KR101457182B1 (en) | 2012-11-07 | 2014-11-03 | (주)에이씨티 | emulsion powder cosmetic composition in solid-in-oil containing water soluble ingredient, and method for manufacturing the same |
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US6361783B2 (en) | 2002-03-26 |
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