CN101563316A - 1-氨基,3-取代的苯基环戊烷羧酸酯的各立体异构体的制备和分离方法 - Google Patents

1-氨基,3-取代的苯基环戊烷羧酸酯的各立体异构体的制备和分离方法 Download PDF

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Publication number
CN101563316A
CN101563316A CNA2007800467996A CN200780046799A CN101563316A CN 101563316 A CN101563316 A CN 101563316A CN A2007800467996 A CNA2007800467996 A CN A2007800467996A CN 200780046799 A CN200780046799 A CN 200780046799A CN 101563316 A CN101563316 A CN 101563316A
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CN
China
Prior art keywords
formula
equation
mixture
compounds
reaction
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Pending
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CNA2007800467996A
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English (en)
Chinese (zh)
Inventor
T·D·戈顿
G·A·怀莱士
M·E·海斯
K·A·卢金
L·王
D·P·费尔南多
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Abbott Laboratories
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Abbott Laboratories
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Publication date
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Publication of CN101563316A publication Critical patent/CN101563316A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/24—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from hydantoins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/26—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing carboxyl groups by reaction with HCN, or a salt thereof, and amines, or from aminonitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/34—Preparation of optical isomers by separation of optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/32—Separation; Purification; Stabilisation; Use of additives
    • C07C253/34—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/69—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by addition to carbon-to-carbon double or triple bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CNA2007800467996A 2006-12-21 2007-12-21 1-氨基,3-取代的苯基环戊烷羧酸酯的各立体异构体的制备和分离方法 Pending CN101563316A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87625106P 2006-12-21 2006-12-21
US60/876,251 2006-12-21

Publications (1)

Publication Number Publication Date
CN101563316A true CN101563316A (zh) 2009-10-21

Family

ID=39562855

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2007800467996A Pending CN101563316A (zh) 2006-12-21 2007-12-21 1-氨基,3-取代的苯基环戊烷羧酸酯的各立体异构体的制备和分离方法

Country Status (9)

Country Link
US (1) US7956195B2 (https=)
EP (1) EP2102145A4 (https=)
JP (1) JP2010513531A (https=)
CN (1) CN101563316A (https=)
CA (1) CA2673076A1 (https=)
MX (1) MX2009006748A (https=)
RU (1) RU2009128063A (https=)
WO (1) WO2008079380A1 (https=)
ZA (1) ZA200903874B (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107759483A (zh) * 2016-08-16 2018-03-06 浙江瑞博制药有限公司 一种甲氨基取代的环戊烷甲酸烷基酯的制备方法

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101999937B1 (ko) * 2010-12-22 2019-07-12 바이엘 인텔렉쳐 프로퍼티 게엠베하 시스-1-암모늄-4-알콕시시클로헥산카보니트릴 염의 제조 방법
CN115847629B (zh) * 2022-11-30 2023-09-29 江苏富乐徳石英科技有限公司 一种高效节能环保的石英环制备工艺

Family Cites Families (14)

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US4841079A (en) * 1987-08-07 1989-06-20 Pfizer, Inc. Process for the production of asymmetric hydantoins
JP3333510B2 (ja) * 1991-10-02 2002-10-15 スミスクライン・ビーチャム・コーポレイション 抗アレルギー、抗炎症および腫瘍壊死因子抑制活性を有するシクロペンタンおよびシクロペンテン誘導体
US5314896A (en) 1991-11-20 1994-05-24 Warner-Lambert Company 1,3-substituted cycloalkenes and cycloalkanes as central nervous system agents
US20020052370A1 (en) * 2000-07-06 2002-05-02 Barber Christopher Gordon Cyclopentyl-substituted glutaramide derivatives as inhibitors of neutral endopeptidase
ATE512217T1 (de) * 2000-09-13 2011-06-15 Ajinomoto Kk 5-substituerte hydantoin racemase, dafür kodierende dna, und verfahren zur herstellung optisch aktiver aminosäure
WO2004022766A1 (ja) * 2002-09-06 2004-03-18 Kaneka Corporation Ｌ−αーメチルシステイン誘導体の製造方法
AR043050A1 (es) * 2002-09-26 2005-07-13 Rib X Pharmaceuticals Inc Compuestos heterociclicos bifuncionales y metodos para preparar y usar los mismos
US7256198B2 (en) * 2004-02-18 2007-08-14 Wyeth Pyrimidoindolones and methods for using same
US7795283B2 (en) * 2004-12-14 2010-09-14 Astrazeneca Ab Oxadiazole derivative as DGAT inhibitors
AU2006214314B2 (en) 2005-02-14 2012-02-09 University Of Virginia Patent Foundation Sphingosine 1- phos phate agonists comprising cycloalkanes and 5 -membered heterocycles substituted by amino and phenyl groups
US7521557B2 (en) * 2005-05-20 2009-04-21 Bristol-Myers Squibb Company Pyrrolopyridine-based inhibitors of dipeptidyl peptidase IV and methods
KR20080086546A (ko) * 2006-01-27 2008-09-25 유니버시티 오브 버지니아 페이턴트 파운데이션 신경병증성 통증의 치료 방법
BRPI0707957A2 (pt) * 2006-02-21 2011-05-17 Univ Virginia Patent Found composto, e, método para prevenção ou tratamento de uma condição ou sintoma patológico em um mamìfero
CL2007003784A1 (es) * 2006-12-21 2008-06-27 Abbott Lab Compuestos derivados de 1-amino-3-fenilciclopentano, que son agonistas o antagonistas de uno o mas receptores de la familia s1p; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar la esclerosis multiple, artritis reumato

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107759483A (zh) * 2016-08-16 2018-03-06 浙江瑞博制药有限公司 一种甲氨基取代的环戊烷甲酸烷基酯的制备方法
CN107759483B (zh) * 2016-08-16 2022-03-11 浙江瑞博制药有限公司 一种甲氨基取代的环戊烷甲酸烷基酯的制备方法

Also Published As

Publication number Publication date
CA2673076A1 (en) 2008-07-03
MX2009006748A (es) 2009-06-30
EP2102145A4 (en) 2014-06-18
ZA200903874B (en) 2010-04-28
US20080255367A1 (en) 2008-10-16
WO2008079380A1 (en) 2008-07-03
JP2010513531A (ja) 2010-04-30
RU2009128063A (ru) 2011-01-27
EP2102145A1 (en) 2009-09-23
US7956195B2 (en) 2011-06-07

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Application publication date: 20091021