JP2010513531A - １−アミノ、３−置換フェニルシクロペンタンカルボン酸エステルの個々の立体異性体の製造および単離方法 - Google Patents

１−アミノ、３−置換フェニルシクロペンタンカルボン酸エステルの個々の立体異性体の製造および単離方法 Download PDF

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JP2010513531A
JP2010513531A JP2009542959A JP2009542959A JP2010513531A JP 2010513531 A JP2010513531 A JP 2010513531A JP 2009542959 A JP2009542959 A JP 2009542959A JP 2009542959 A JP2009542959 A JP 2009542959A JP 2010513531 A JP2010513531 A JP 2010513531A
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formula
compound
mixture
reaction
compounds
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JP2010513531A5 (https=
Inventor
ゴードン，トーマス・デイー
ウオーレス，グリアー・エイ
ヘイズ，マーテイン・イー
ルーキン，キリル・エイ
ワン，レイ
フエルナンド，デイリニー・ピー
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Abbott Laboratories
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Abbott Laboratories
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Publication of JP2010513531A publication Critical patent/JP2010513531A/ja
Publication of JP2010513531A5 publication Critical patent/JP2010513531A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/24—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from hydantoins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/26—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing carboxyl groups by reaction with HCN, or a salt thereof, and amines, or from aminonitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/34—Preparation of optical isomers by separation of optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/32—Separation; Purification; Stabilisation; Use of additives
    • C07C253/34—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/69—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by addition to carbon-to-carbon double or triple bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
JP2009542959A 2006-12-21 2007-12-21 １−アミノ、３−置換フェニルシクロペンタンカルボン酸エステルの個々の立体異性体の製造および単離方法 Withdrawn JP2010513531A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87625106P 2006-12-21 2006-12-21
PCT/US2007/026257 WO2008079380A1 (en) 2006-12-21 2007-12-21 Process for the preparation and isolation of the individual stereoisomers of 1-amino, 3-substituted phenylcyclopentane carboxylates

Publications (2)

Publication Number Publication Date
JP2010513531A true JP2010513531A (ja) 2010-04-30
JP2010513531A5 JP2010513531A5 (https=) 2011-03-24

Family

ID=39562855

Family Applications (1)

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JP2009542959A Withdrawn JP2010513531A (ja) 2006-12-21 2007-12-21 １−アミノ、３−置換フェニルシクロペンタンカルボン酸エステルの個々の立体異性体の製造および単離方法

Country Status (9)

Country Link
US (1) US7956195B2 (https=)
EP (1) EP2102145A4 (https=)
JP (1) JP2010513531A (https=)
CN (1) CN101563316A (https=)
CA (1) CA2673076A1 (https=)
MX (1) MX2009006748A (https=)
RU (1) RU2009128063A (https=)
WO (1) WO2008079380A1 (https=)
ZA (1) ZA200903874B (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014509304A (ja) * 2010-12-22 2014-04-17 バイエル・インテレクチユアル・プロパテイー・ゲー・エム・ベー・ハー シス−１−アンモニウム−４−アルコキシシクロヘキサンカルボニトリル塩類を調製する方法

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107759483B (zh) * 2016-08-16 2022-03-11 浙江瑞博制药有限公司 一种甲氨基取代的环戊烷甲酸烷基酯的制备方法
CN115847629B (zh) * 2022-11-30 2023-09-29 江苏富乐徳石英科技有限公司 一种高效节能环保的石英环制备工艺

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4841079A (en) * 1987-08-07 1989-06-20 Pfizer, Inc. Process for the production of asymmetric hydantoins
JP3333510B2 (ja) * 1991-10-02 2002-10-15 スミスクライン・ビーチャム・コーポレイション 抗アレルギー、抗炎症および腫瘍壊死因子抑制活性を有するシクロペンタンおよびシクロペンテン誘導体
US5314896A (en) 1991-11-20 1994-05-24 Warner-Lambert Company 1,3-substituted cycloalkenes and cycloalkanes as central nervous system agents
US20020052370A1 (en) * 2000-07-06 2002-05-02 Barber Christopher Gordon Cyclopentyl-substituted glutaramide derivatives as inhibitors of neutral endopeptidase
ATE512217T1 (de) * 2000-09-13 2011-06-15 Ajinomoto Kk 5-substituerte hydantoin racemase, dafür kodierende dna, und verfahren zur herstellung optisch aktiver aminosäure
WO2004022766A1 (ja) * 2002-09-06 2004-03-18 Kaneka Corporation Ｌ−αーメチルシステイン誘導体の製造方法
AR043050A1 (es) * 2002-09-26 2005-07-13 Rib X Pharmaceuticals Inc Compuestos heterociclicos bifuncionales y metodos para preparar y usar los mismos
US7256198B2 (en) * 2004-02-18 2007-08-14 Wyeth Pyrimidoindolones and methods for using same
US7795283B2 (en) * 2004-12-14 2010-09-14 Astrazeneca Ab Oxadiazole derivative as DGAT inhibitors
AU2006214314B2 (en) 2005-02-14 2012-02-09 University Of Virginia Patent Foundation Sphingosine 1- phos phate agonists comprising cycloalkanes and 5 -membered heterocycles substituted by amino and phenyl groups
US7521557B2 (en) * 2005-05-20 2009-04-21 Bristol-Myers Squibb Company Pyrrolopyridine-based inhibitors of dipeptidyl peptidase IV and methods
KR20080086546A (ko) * 2006-01-27 2008-09-25 유니버시티 오브 버지니아 페이턴트 파운데이션 신경병증성 통증의 치료 방법
BRPI0707957A2 (pt) * 2006-02-21 2011-05-17 Univ Virginia Patent Found composto, e, método para prevenção ou tratamento de uma condição ou sintoma patológico em um mamìfero
CL2007003784A1 (es) * 2006-12-21 2008-06-27 Abbott Lab Compuestos derivados de 1-amino-3-fenilciclopentano, que son agonistas o antagonistas de uno o mas receptores de la familia s1p; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar la esclerosis multiple, artritis reumato

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014509304A (ja) * 2010-12-22 2014-04-17 バイエル・インテレクチユアル・プロパテイー・ゲー・エム・ベー・ハー シス−１−アンモニウム−４−アルコキシシクロヘキサンカルボニトリル塩類を調製する方法

Also Published As

Publication number Publication date
CA2673076A1 (en) 2008-07-03
MX2009006748A (es) 2009-06-30
EP2102145A4 (en) 2014-06-18
ZA200903874B (en) 2010-04-28
CN101563316A (zh) 2009-10-21
US20080255367A1 (en) 2008-10-16
WO2008079380A1 (en) 2008-07-03
RU2009128063A (ru) 2011-01-27
EP2102145A1 (en) 2009-09-23
US7956195B2 (en) 2011-06-07

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