CN101538246B - 作为pgds抑制剂的嘧啶酰胺化合物 - Google Patents

作为pgds抑制剂的嘧啶酰胺化合物 Download PDF

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Publication number
CN101538246B
CN101538246B CN200910138053.9A CN200910138053A CN101538246B CN 101538246 B CN101538246 B CN 101538246B CN 200910138053 A CN200910138053 A CN 200910138053A CN 101538246 B CN101538246 B CN 101538246B
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CN
China
Prior art keywords
phenyl
pyrimidine
formic acid
acid amides
methyl
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Active
Application number
CN200910138053.9A
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English (en)
Chinese (zh)
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CN101538246A (zh
Inventor
S·C·奥尔德斯
J·Z·姜
卢锦琪
马良
牟岚
H·R·芒森
J·S·萨博尔
S·图赖拉特奈姆
C·L·范德森
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Auin Thurber holding Co.
Auin Thurber Limited by Share Ltd.
Aventis Saab LLC
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Aventis Pharmaceuticals Inc
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Publication of CN101538246A publication Critical patent/CN101538246A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN200910138053.9A 2005-10-04 2006-10-04 作为pgds抑制剂的嘧啶酰胺化合物 Active CN101538246B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72357005P 2005-10-04 2005-10-04
US60/723,570 2005-10-04

Related Parent Applications (1)

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CNA2006800365786A Division CN101282943A (zh) 2005-10-04 2006-10-04 作为pgds抑制剂的嘧啶酰胺化合物

Publications (2)

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CN101538246A CN101538246A (zh) 2009-09-23
CN101538246B true CN101538246B (zh) 2014-07-16

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ID=37635758

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CN200910138053.9A Active CN101538246B (zh) 2005-10-04 2006-10-04 作为pgds抑制剂的嘧啶酰胺化合物
CNA2006800365786A Pending CN101282943A (zh) 2005-10-04 2006-10-04 作为pgds抑制剂的嘧啶酰胺化合物

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US (1) US8202863B2 (cg-RX-API-DMAC7.html)
EP (1) EP1937652B1 (cg-RX-API-DMAC7.html)
JP (1) JP5452925B2 (cg-RX-API-DMAC7.html)
KR (1) KR101457966B1 (cg-RX-API-DMAC7.html)
CN (2) CN101538246B (cg-RX-API-DMAC7.html)
AR (1) AR056871A1 (cg-RX-API-DMAC7.html)
AU (1) AU2006299428B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0616815A2 (cg-RX-API-DMAC7.html)
CA (1) CA2624749C (cg-RX-API-DMAC7.html)
CR (1) CR9832A (cg-RX-API-DMAC7.html)
DO (1) DOP2006000210A (cg-RX-API-DMAC7.html)
EC (1) ECSP088335A (cg-RX-API-DMAC7.html)
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PE (2) PE20110118A1 (cg-RX-API-DMAC7.html)
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TW (1) TWI415839B (cg-RX-API-DMAC7.html)
UA (1) UA93213C2 (cg-RX-API-DMAC7.html)
UY (1) UY29840A1 (cg-RX-API-DMAC7.html)
WO (1) WO2007041634A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA200802222B (cg-RX-API-DMAC7.html)

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Also Published As

Publication number Publication date
TWI415839B (zh) 2013-11-21
ECSP088335A (es) 2008-05-30
JP5452925B2 (ja) 2014-03-26
IL190411A0 (en) 2008-11-03
MY151172A (en) 2014-04-30
SG166121A1 (en) 2010-11-29
DOP2006000210A (es) 2007-06-15
KR101457966B1 (ko) 2014-11-04
CA2624749A1 (en) 2007-04-12
TW200812977A (en) 2008-03-16
US8202863B2 (en) 2012-06-19
NO20082000L (no) 2008-06-09
WO2007041634A1 (en) 2007-04-12
ZA200802222B (en) 2009-09-30
MA29925B1 (fr) 2008-11-03
CA2624749C (en) 2011-08-16
PE20070589A1 (es) 2007-06-22
KR20080050611A (ko) 2008-06-09
UY29840A1 (es) 2007-05-31
RU2008117170A (ru) 2009-11-10
CR9832A (es) 2008-06-18
RU2420519C2 (ru) 2011-06-10
ES2514471T3 (es) 2014-10-28
TNSN08104A1 (en) 2009-07-14
NZ567208A (en) 2011-03-31
AU2006299428B2 (en) 2012-04-26
CN101538246A (zh) 2009-09-23
BRPI0616815A2 (pt) 2011-07-05
JP2009510170A (ja) 2009-03-12
AU2006299428A1 (en) 2007-04-12
AR056871A1 (es) 2007-10-31
US20080227782A1 (en) 2008-09-18
EP1937652A1 (en) 2008-07-02
EP1937652B1 (en) 2014-07-30
IL190411A (en) 2013-09-30
UA93213C2 (en) 2011-01-25
PE20110118A1 (es) 2011-03-08
CN101282943A (zh) 2008-10-08

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