CN101351213B - 使用表达gm-csf的痘病毒系统性治疗转移性癌和/或全身散布性癌 - Google Patents
使用表达gm-csf的痘病毒系统性治疗转移性癌和/或全身散布性癌 Download PDFInfo
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Abstract
Description
氨基酸 | 密码子 | ||
丙氨酸 | Ala | A | GCA GCC GCG GCU |
半胱氨酸 | Cys | C | UGC UGU |
天冬氨酸 | Asp | D | GAC GAU |
谷氨酸 | Glu | E | GAA GAG |
苯丙氨酸 | Phe | F | UUC UUU |
甘氨酸 | Gly | G | GGA GGC GGG GGU |
组氨酸 | His | H | CAC CAU |
异亮氨酸 | Ile | I | AUA AUC AUU |
赖氨酸 | Lys | K | AAA AAG |
亮氨酸 | Leu | L | UUA UUG CUA CUC CUG CUU |
甲硫氨酸 | Met | M | AUG |
天冬酰胺 | Asn | N | AAC AAU |
脯氨酸 | Pro | P | CCA CCC CCG CCU |
谷氨酰胺 | Gln | Q | CAA CAG |
精氨酸 | Arg | R | AGA AGG CGA CGC CGG CGU |
丝氨酸 | Ser | S | AGC AGU UCA UCC UCG UCU |
苏氨酸 | Thr | T | ACA ACC ACG ACU |
缬氨酸 | Val | V | GUA GUC GUG GUU |
色氨酸 | Trp | W | UGG |
酪氨酸 | Tyr | Y | UAC UAU |
白介素-2 | Greene等,1989 |
白介素-2受体 | Greene等,1989;Lin等,1990 |
II类MHC 5 | Koch等,1989 |
II类MHC HLA-DRa | Sherman等,1989 |
β-肌动蛋白 | Kawamoto等,1988;Ng等;1989 |
肌酸激酶(MCK) | Jaynes等,1988;Horlick等,1989;Johnson等,1989 |
前白蛋白(转甲状腺 素蛋白) | Costa等,1988 |
弹性蛋白酶I | Omitz等,1987 |
镉结合蛋白(MTII) | Karin等,1987;Culotta等,1989 |
胶原酶 | Pinkert等,1987;Angel等,1987 |
白蛋白 | Pinkert等,1987;Tronche等,1989,1990 |
α-胎儿球蛋白 | Godbout等,1988;Campere等,1989 |
γ-珠蛋白 | Bodine等,1987;Perez-Stable等,1990 |
β-珠蛋白 | Trudel等,1987 |
c-fos | Cohen等,1987 |
c-HA-ras | Triesman,1986;Deschamps等,1985 |
胰岛素 | Edlund等,1985 |
神经细胞粘连因子 (NCAM) | Hirsh等,1990 |
α-抗胰蛋白酶 | Latimer等,1990 |
H2B(TH2B)组蛋白 | Hwang等,1990 |
小鼠和/或I型胶原 蛋白 | Ripe等,1.989 |
葡萄糖调节蛋白 (GRP94和GRP78) | Chang等,1989 |
鼠生长激素 | Larsen等,1986 |
人血清淀粉状蛋白 A(SAA) | Edbrooke等,1989 |
肌钙蛋白I(TN I) | Yutzey等,1989 |
血小板衍生的生长 因子(PDGF) | Pech等,1989 |
进行性假肥大性肌 营养不良 | Kiamut等,1990 |
SV40 | Banerji等,1981;Moreau等,1981;Sleigh等, 1985;Firak等,1986;Herr等,1986;Imbra等, 1986;Kadesch等,1986;Wang等,1986;Ondek 等,1987;KuhI等,1987;Schaffner等,1988 |
多瘤 | Swartzendruber等,1975;Vasseur等,1980; Katinka等,1980,1981;Tyndell等,1981; Dandolo等,1983;de Villiers等,1984;Hen等, 1986;Satake等.,1988;Campbell等,1988 |
逆转录病毒 | Kriegler等,1982,1983;Levinson等,1982; Kriegler等,1983,1984a,b,1988;Bosze等, 1986;Miksicek等,1986;Celancler等,1987; Thiesen等,1988;Celander等,1988;Chol等, 1988;Reisman等,1989 |
乳头状瘤病毒 | Campo等,1983;Lusky等,1983;Spandidos and Wilkie,1983;Spalholz等,1985;Lusky等,1986; Cripe等,1987;Gloss等,1987;Hirochika等, 1987;Stephens等,1987 |
乙型肝炎病毒 | Bulla等,1986;Jameel等,1986;Shaul等,1987;Spandau 等,1988;Vannice等,1988 |
人免疫缺陷症病毒 | Muesing等,1987;Hauber等,1988;Jakobovits等,1988; Feng等,1988;Takebe等,1988;Rosen等,1988;Berkhout 等,1989;Laspia等,1989;Sharp等,1989;Braddock等,1989 |
巨细胞病毒(CMV) | Weber等,1984;Boshart等,1985;Foecking等,1986 |
长臂猿白血病病毒 | Holbrook等,1987;Quinn等,1989 |
组织特异性启动子 | 启动子在其中有活性的癌 | 启动子在其中有活性的正常细胞 |
癌胚抗原(CEA)* | 大多数结肠直肠癌;50%的肺癌; 40-50%的胃癌;大多数胰腺癌;许 多乳癌 | 结肠粘膜;胃粘膜;肺上皮;外泌汗 腺;睾丸中的细胞 |
前列腺特异性抗原(PSA) | 大多数前列腺癌 | 前列腺癌上皮 |
血管活性肠肽(VIP) | 大多数非小细胞肺癌 | 神经元;淋巴细胞;肥大细胞;嗜酸 粒细胞 |
表面活性蛋白A(SP-A) | 许多肺腺癌细胞 | II型肺细胞;克拉拉细胞 |
人achaete-scute同系物 (hASH) | 大多数小细胞肺癌 | 肺中的神经内分泌细胞 |
粘蛋白-1(MUC1)** | 大多数腺癌(源于任何组织) | 乳房以及呼吸道、胃肠道和生殖泌尿 道中的腺上皮细胞 |
α-胎儿球蛋白 | 大多数肝细胞癌;可能许多睾丸癌 | 肝细胞(在某些情况下);睾丸 |
白蛋白 | 大多数肝细胞癌 | 肝细胞 |
酪氨酸酶 | 大多数黑素瘤 | 黑素细胞;星形细胞;施旺细胞;一 些神经元 |
酪氨酸结合蛋白(TRP) | 大多数黑素瘤 | 黑素细胞;星形细胞;施旺细胞;一 些神经元 |
角蛋白14 | 大概许多鳞状细胞癌(例如,头颈 癌) | 角质化细胞 |
EBV LD-2 | 头和颈的许多鳞状细胞癌 | 上消化道的上层消化性角质细胞的 角质细胞 |
胶质纤维酸性蛋白(GFAP) | 许多星形细胞瘤 | 星形细胞 |
髓磷脂碱蛋白(MBP) | 许多神经胶质瘤 | 少突胶质细胞 |
睾丸-特异性血管紧张素 转化酶(睾丸-特异性 ACE) | 可能许多睾丸癌 | 精子 |
骨钙素 | 可能许多骨肉瘤 | 成骨细胞 |
启动子 | 启动子在其中有活性的癌 | 启动子在其中有活性的正常细胞 |
E2F-调控 启动子 | 几乎所有癌 | 增生性细胞 |
HLA-G | 许多结肠直肠癌;许多黑素瘤;可能大多 数的其它癌 | 淋巴细胞;单核细胞;精母细胞;滋养层 |
FasL | 大多数黑素瘤;许多胰腺癌;大多数星形 细胞瘤;可能大多数的其它癌 | 活化的白细胞;神经元;内皮细胞;角质化 细胞;免疫豁免组织中的细胞;肺、卵巢、 肝脏和前列腺中的一些细胞 |
Myc-调控 启动子 | 大多数肺癌(小细胞和非小细胞型两者); 大多数结肠直肠癌 | 增生性细胞(仅一些细胞类型):乳房上皮细 胞(包括非增生性细胞) |
MAGE-1 | 许多黑素瘤;一些非小细胞肺癌;一些乳 癌 | 睾丸 |
VEGF | 70%的所有癌(在许多癌中组成型过度表 达) | 新血管形成部位的细胞((但是不像在肿瘤 中,表达是暂时的、较弱并且不是组成型的) |
bFGF | 可能许多不同的癌,因为bFGF表达由缺血 状况诱导 | 缺血部位的细胞(但不像在肿瘤中,表达是 暂时的、较弱并且不是组成型的) |
COX-2 | 大多数结肠直肠癌;许多肺癌;可能许多 的其它癌 | 炎症部位的细胞 |
IL-10 | 大多数结肠直肠癌;许多肺癌;头和颈的 许多鳞状细胞癌;可能许多的其它癌 | 白细胞 |
GRP78/BiP | 可能许多不同的癌,因为GRP7S表达是由 肿瘤特异性条件诱导 | 缺血部位的细胞 |
来自 Egr-1的 CarG元件 | 通过电离辐射诱导,所以在辐射是可能是 大多数肿瘤 | 曝露于电离辐射的细胞;白细胞 |
HPMS1 | HNPCC | 错配修复;MutL同 系物 | |
hPMS2 | HNPCC | 错配修复;MutL同 系物 | |
INK4/MTS1 | 9p21处邻近的INK-4B; CDK复合物 | 候选的MTS1抑 制物和MLM黑素 瘤基因 | P16CDK抑制物 |
INK4B/MTS2 | 候选抑制物 | P15CDK抑制物 | |
MDM-2 | 扩增 | 肉瘤 | 负调节物p53 |
P53 | 与SV40 T抗原结合 | 突变>50%的人肿 瘤,包括遗传性 的Li-Fraumeni 综合征 | 转录因子;关卡控 制;凋亡 |
PRAD1/BCL1 | 与甲状旁腺的或IgG易 位 | 甲状旁腺腺瘤; B-CLL | 周期蛋白D |
RB | 遗传性视网膜母细胞 瘤;与许多DNA病毒抗 原关联 | 视网膜母细胞 瘤;骨肉瘤;乳 癌;其他散发性 癌 | 与周期蛋白/cdk 相互作用;调节 E2F转录因子 |
XPA | 着色性干皮病; 皮肤癌素质 |
Claims (20)
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US71467905P | 2005-09-07 | 2005-09-07 | |
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PCT/US2006/034945 WO2007030668A2 (en) | 2005-09-07 | 2006-09-07 | Systemic treatment of metastatic and/or systemically-disseminated cancers using gm-csf-expressing poxviruses |
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1578396A4 (en) * | 2002-08-12 | 2007-01-17 | David Kirn | METHODS AND COMPOSITIONS RELATING TO POXVIRUS AND CANCER |
US8980246B2 (en) * | 2005-09-07 | 2015-03-17 | Sillajen Biotherapeutics, Inc. | Oncolytic vaccinia virus cancer therapy |
KR101772375B1 (ko) * | 2005-09-07 | 2017-08-29 | 신라젠(주) | Gm-csf를 발현하는 폭스바이러스를 사용한 전이성 및/또는 전신 파종성 암의 전신 치료법 |
US8392560B2 (en) | 2006-04-28 | 2013-03-05 | Microsoft Corporation | Offering and provisioning secured wireless virtual private network services |
WO2008009115A1 (en) * | 2006-07-18 | 2008-01-24 | Ottawa Health Research Institute | Disparate suicide carrier cells for tumor targeting of promiscuous oncolytic viruses |
WO2008100292A2 (en) | 2006-10-16 | 2008-08-21 | Genelux Corporation | Modified vaccinia virus strains for use in diagnostic and therapeutic methods |
KR20080084528A (ko) * | 2007-03-15 | 2008-09-19 | 제네렉스 바이오테라퓨틱스 인크. | 종양살상형 백시니아 바이러스 암 치료 |
WO2008156655A2 (en) * | 2007-06-15 | 2008-12-24 | Genelux Corporation | Vaccinia virus vectors encoding a sodium-dependent transporter protein for imaging and/or treatment of tumors |
ES2848650T3 (es) | 2009-09-14 | 2021-08-11 | Sillajen Biotherapeutics Inc | Terapia combinada contra el cáncer con virus vaccinia oncolítico |
BR112013017096A2 (pt) * | 2011-01-04 | 2020-09-01 | Jennerex Inc. | composição e métodos de indução de resposta citotóxica dependente de complemento mediado por anticorpo específico de tumor em animal tendo tumor, de geração de anticorpos in vivo, de inibição do crescimento ou morte de célula de câncer, para tratar indivíduo com câncer, para adaptar de terapia de câncer para indivíduo com câncer e para identificar antígeno específico de tumor |
US20120237481A1 (en) * | 2011-03-17 | 2012-09-20 | Xiaoliu Zhang | Incorporation of the B18R gene to enhance antitumor effect of virotherapy |
JP6415977B2 (ja) | 2011-04-15 | 2018-10-31 | ジェネラックス・コーポレイションGenelux Corporation | 弱毒化ワクシニアウイルスのクローン株およびその使用方法 |
EP2739293B1 (en) * | 2011-08-05 | 2020-06-10 | SillaJen Biotherapeutics, Inc. | Methods and compositions for production of vaccina virus |
WO2013052915A2 (en) | 2011-10-05 | 2013-04-11 | Genelux Corporation | Method for detecting replication or colonization of a biological therapeutic |
TWI690322B (zh) | 2012-10-02 | 2020-04-11 | 法商傳斯堅公司 | 含病毒的調配物及其使用 |
CA2909225C (en) * | 2013-04-10 | 2019-06-18 | Tot Shanghai R&D Center Co., Ltd. | Mutant vaccinia virus strains, uses thereof and method of producing the same |
FI3778897T3 (fi) * | 2013-08-22 | 2024-01-25 | Univ Pittsburgh Commonwealth Sys Higher Education | Immuno-onkolyyttisiä hoitoja |
GB201405834D0 (en) * | 2014-04-01 | 2014-05-14 | Univ London Queen Mary | Oncolytic virus |
MX2017007178A (es) | 2014-12-01 | 2017-08-28 | Transgene Sa | Formulaciones liquidas estables de virus de vacuna. |
EP3310383B1 (en) * | 2015-06-19 | 2020-02-19 | Sillajen, Inc. | Compositions and methods for viral embolization |
CN108350434B (zh) * | 2015-09-08 | 2022-06-07 | 新罗杰股份有限公司 | 表达细胞因子和羧酸酯酶的修饰的溶瘤痘苗病毒及其使用方法 |
CN108738345A (zh) * | 2016-02-24 | 2018-11-02 | 国立大学法人大阪大学 | 试验方法 |
JP2020514324A (ja) * | 2017-02-03 | 2020-05-21 | ユニバーシティ オブ ピッツバーグ −オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション | 腫瘍溶解性ウイルス療法 |
PE20200303A1 (es) | 2017-05-24 | 2020-02-06 | Novartis Ag | Proteinas de anticuerpo injertadas con citocina y metodos de uso en el tratamiento del cancer |
CN107164337B (zh) * | 2017-05-26 | 2020-08-04 | 云南省第一人民医院 | 含ccl5和sstr2基因的重组痘病毒及其制备方法 |
CN109554353B (zh) * | 2017-09-26 | 2021-08-06 | 杭州康万达医药科技有限公司 | 分离的重组溶瘤痘病毒、药物组合物及其在治疗肿瘤和/或癌症的药物中的用途 |
US20220288143A1 (en) * | 2019-08-29 | 2022-09-15 | Bionoxx Inc. | Pharmaceutical composition for treating cancer, comprising vaccinia virus and granulopoiesis inhibitor as active ingredients |
CN111150748A (zh) * | 2019-12-27 | 2020-05-15 | 杭州荣谷生物科技有限公司 | 重组溶瘤病毒在制备治疗消化道癌药物中的用途 |
Family Cites Families (140)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US553880A (en) * | 1896-02-04 | Workman s time-recorder | ||
US4554101A (en) | 1981-01-09 | 1985-11-19 | New York Blood Center, Inc. | Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity |
US5833975A (en) | 1989-03-08 | 1998-11-10 | Virogenetics Corporation | Canarypox virus expressing cytokine and/or tumor-associated antigen DNA sequence |
NL8200523A (nl) | 1982-02-11 | 1983-09-01 | Univ Leiden | Werkwijze voor het in vitro transformeren van planteprotoplasten met plasmide-dna. |
US4879236A (en) | 1984-05-16 | 1989-11-07 | The Texas A&M University System | Method for producing a recombinant baculovirus expression vector |
US4957858A (en) | 1986-04-16 | 1990-09-18 | The Salk Instute For Biological Studies | Replicative RNA reporter systems |
US4883750A (en) | 1984-12-13 | 1989-11-28 | Applied Biosystems, Inc. | Detection of specific sequences in nucleic acids |
US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
US4946773A (en) | 1985-12-23 | 1990-08-07 | President And Fellows Of Harvard College | Detection of base pair mismatches using RNAase A |
US4800159A (en) | 1986-02-07 | 1989-01-24 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences |
US5824311A (en) | 1987-11-30 | 1998-10-20 | Trustees Of The University Of Pennsylvania | Treatment of tumors with monoclonal antibodies against oncogene antigens |
US4952500A (en) | 1988-02-01 | 1990-08-28 | University Of Georgia Research Foundation, Inc. | Cloning systems for Rhodococcus and related bacteria |
EP0365627B1 (en) | 1988-03-24 | 1993-12-22 | University Of Iowa Research Foundation | Catalytic hybridization systems for the detection of nucleic acid sequences based on their activity as cofactors in catalytic reactions in which a complementary labeled nucleic acid probe is cleaved |
US5858652A (en) | 1988-08-30 | 1999-01-12 | Abbott Laboratories | Detection and amplification of target nucleic acid sequences |
US5151509A (en) | 1988-12-16 | 1992-09-29 | United States Of America | Gene encoding serine protease inhibitor |
US5856092A (en) | 1989-02-13 | 1999-01-05 | Geneco Pty Ltd | Detection of a nucleic acid sequence or a change therein |
US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
US5284760A (en) | 1989-04-03 | 1994-02-08 | Feinstone Stephen M | Techniques for producing site-directed mutagenesis of cloned DNA |
US5302523A (en) | 1989-06-21 | 1994-04-12 | Zeneca Limited | Transformation of plant cells |
US5550318A (en) | 1990-04-17 | 1996-08-27 | Dekalb Genetics Corporation | Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof |
US7705215B1 (en) | 1990-04-17 | 2010-04-27 | Dekalb Genetics Corporation | Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof |
US5073627A (en) | 1989-08-22 | 1991-12-17 | Immunex Corporation | Fusion proteins comprising GM-CSF and IL-3 |
US5322783A (en) | 1989-10-17 | 1994-06-21 | Pioneer Hi-Bred International, Inc. | Soybean transformation by microparticle bombardment |
US5484956A (en) | 1990-01-22 | 1996-01-16 | Dekalb Genetics Corporation | Fertile transgenic Zea mays plant comprising heterologous DNA encoding Bacillus thuringiensis endotoxin |
US5149797A (en) | 1990-02-15 | 1992-09-22 | The Worcester Foundation For Experimental Biology | Method of site-specific alteration of rna and production of encoded polypeptides |
US5466468A (en) | 1990-04-03 | 1995-11-14 | Ciba-Geigy Corporation | Parenterally administrable liposome formulation comprising synthetic lipids |
JP4251406B2 (ja) | 1990-04-05 | 2009-04-08 | クレア,ロベルト | ウォーク―スルー突然変異誘発 |
US5849481A (en) | 1990-07-27 | 1998-12-15 | Chiron Corporation | Nucleic acid hybridization assays employing large comb-type branched polynucleotides |
US5645987A (en) | 1990-09-21 | 1997-07-08 | Amgen Inc. | Enzymatic synthesis of oligonucleotides |
US5798339A (en) | 1990-12-17 | 1998-08-25 | University Of Manitoba | Treatment method for cancer |
US5384253A (en) | 1990-12-28 | 1995-01-24 | Dekalb Genetics Corporation | Genetic transformation of maize cells by electroporation of cells pretreated with pectin degrading enzymes |
US5399363A (en) | 1991-01-25 | 1995-03-21 | Eastman Kodak Company | Surface modified anticancer nanoparticles |
CA2105277C (en) | 1991-03-07 | 2006-12-12 | William I. Cox | Genetically engineered vaccine strain |
DE69233158T2 (de) | 1991-03-07 | 2004-05-13 | Connaught Technology Corp., Greenville | Gentechnologisch hergestellter stamm für impfstoffe |
GB9105383D0 (en) | 1991-03-14 | 1991-05-01 | Immunology Ltd | An immunotherapeutic for cervical cancer |
WO1993004169A1 (en) | 1991-08-20 | 1993-03-04 | Genpharm International, Inc. | Gene targeting in animal cells using isogenic dna constructs |
US5846717A (en) | 1996-01-24 | 1998-12-08 | Third Wave Technologies, Inc. | Detection of nucleic acid sequences by invader-directed cleavage |
US5610042A (en) | 1991-10-07 | 1997-03-11 | Ciba-Geigy Corporation | Methods for stable transformation of wheat |
US5849486A (en) | 1993-11-01 | 1998-12-15 | Nanogen, Inc. | Methods for hybridization analysis utilizing electrically controlled hybridization |
EP1393730A3 (en) | 1991-11-15 | 2004-03-17 | Smithkline Beecham Corporation | Combination chemotherapy involving topotecan and a platinum coordination compound |
US5846708A (en) | 1991-11-19 | 1998-12-08 | Massachusetts Institiute Of Technology | Optical and electrical methods and apparatus for molecule detection |
JP3398957B2 (ja) | 1991-12-24 | 2003-04-21 | ザ・プレジデント・アンド・フエローズ・オブ・ハーバード・カレツジ | Dnaの特定部位の突然変異誘発 |
US20020146702A1 (en) | 1992-01-31 | 2002-10-10 | Vielkind Juergen R. | Nucleic acid molecule associated with prostate cancer and melanoma immunodetection and immunotherapy |
AT400033B (de) * | 1992-03-10 | 1995-09-25 | Biochemie Gmbh | Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben |
WO1993020235A1 (en) | 1992-04-01 | 1993-10-14 | The Johns Hopkins University School Of Medicine | Methods of detecting mammalian nucleic acids isolated from stool specimen and reagents therefor |
US5843640A (en) | 1992-06-19 | 1998-12-01 | Northwestern University | Method of simultaneously detecting amplified nucleic acid sequences and cellular antigens in cells |
EP0604662B1 (en) | 1992-07-07 | 2008-06-18 | Japan Tobacco Inc. | Method of transforming monocotyledon |
US5702932A (en) | 1992-07-20 | 1997-12-30 | University Of Florida | Microinjection methods to transform arthropods with exogenous DNA |
JP2952041B2 (ja) | 1992-07-27 | 1999-09-20 | パイオニア ハイ−ブレッド インターナショナル,インコーポレイテッド | 培養ダイズ細胞のagrobacterium媒介形質転換の改良法 |
US5636377A (en) * | 1992-08-19 | 1997-06-10 | Hipco, Inc. | Hip protection device for the elderly |
DE4228457A1 (de) | 1992-08-27 | 1994-04-28 | Beiersdorf Ag | Herstellung von heterodimerem PDGF-AB mit Hilfe eines bicistronischen Vektorsystems in Säugerzellen |
US5389514A (en) | 1992-08-28 | 1995-02-14 | Fox Chase Cancer Center | Method for specifically altering the nucleotide sequence of RNA |
US5861244A (en) | 1992-10-29 | 1999-01-19 | Profile Diagnostic Sciences, Inc. | Genetic sequence assay using DNA triple strand formation |
GB9222888D0 (en) | 1992-10-30 | 1992-12-16 | British Tech Group | Tomography |
US5801029A (en) | 1993-02-16 | 1998-09-01 | Onyx Pharmaceuticals, Inc. | Cytopathic viruses for therapy and prophylaxis of neoplasia |
US5801005A (en) | 1993-03-17 | 1998-09-01 | University Of Washington | Immune reactivity to HER-2/neu protein for diagnosis of malignancies in which the HER-2/neu oncogene is associated |
US5658751A (en) | 1993-04-13 | 1997-08-19 | Molecular Probes, Inc. | Substituted unsymmetrical cyanine dyes with selected permeability |
US5279721A (en) | 1993-04-22 | 1994-01-18 | Peter Schmid | Apparatus and method for an automated electrophoresis system |
GB9311386D0 (en) | 1993-06-02 | 1993-07-21 | Pna Diagnostics As | Nucleic acid analogue assay procedures |
US5846709A (en) | 1993-06-15 | 1998-12-08 | Imclone Systems Incorporated | Chemical process for amplifying and detecting nucleic acid sequences |
US5543158A (en) | 1993-07-23 | 1996-08-06 | Massachusetts Institute Of Technology | Biodegradable injectable nanoparticles |
FR2708288B1 (fr) | 1993-07-26 | 1995-09-01 | Bio Merieux | Procédé d'amplification d'acides nucléiques par transcription utilisant le déplacement, réactifs et nécessaire pour la mise en Óoeuvre de ce procédé. |
FR2710536B1 (fr) * | 1993-09-29 | 1995-12-22 | Transgene Sa | Usage anti-cancéreux d'un vecteur viral comportant un gène modulateur de la réponse immunitaire et/ou inflammatoire. |
US5969094A (en) | 1993-10-12 | 1999-10-19 | Emory University | Anti-paramyxovirus screening method and vaccine |
US5925517A (en) | 1993-11-12 | 1999-07-20 | The Public Health Research Institute Of The City Of New York, Inc. | Detectably labeled dual conformation oligonucleotide probes, assays and kits |
GB2284208A (en) | 1993-11-25 | 1995-05-31 | Pna Diagnostics As | Nucleic acid analogues with a chelating functionality for metal ions |
JP2935950B2 (ja) | 1993-12-03 | 1999-08-16 | 株式会社山田製作所 | ステアリングシャフト及びその製造装置 |
EP0663447B1 (en) | 1993-12-28 | 2003-07-09 | Eiken Chemical Co., Ltd. | Method of detecting a specific polynucleotide |
US5851770A (en) | 1994-04-25 | 1998-12-22 | Variagenics, Inc. | Detection of mismatches by resolvase cleavage using a magnetic bead support |
US5656465A (en) | 1994-05-04 | 1997-08-12 | Therion Biologics Corporation | Methods of in vivo gene delivery |
US6093700A (en) | 1995-05-11 | 2000-07-25 | Thomas Jefferson University | Method of inducing an immune response using vaccinia virus recombinants encoding GM-CSF |
JPH10500862A (ja) | 1994-05-28 | 1998-01-27 | テプネル・メディカル・リミテッド | 核酸のコピーの産生 |
US5656610A (en) | 1994-06-21 | 1997-08-12 | University Of Southern California | Producing a protein in a mammal by injection of a DNA-sequence into the tongue |
US5942391A (en) | 1994-06-22 | 1999-08-24 | Mount Sinai School Of Medicine | Nucleic acid amplification method: ramification-extension amplification method (RAM) |
US5849483A (en) | 1994-07-28 | 1998-12-15 | Ig Laboratories, Inc. | High throughput screening method for sequences or genetic alterations in nucleic acids |
EP0777749B1 (en) | 1994-08-19 | 2002-10-30 | PE Corporation (NY) | Coupled amplification and ligation method |
GB9506466D0 (en) | 1994-08-26 | 1995-05-17 | Prolifix Ltd | Cell cycle regulated repressor and dna element |
US5599668A (en) | 1994-09-22 | 1997-02-04 | Abbott Laboratories | Light scattering optical waveguide method for detecting specific binding events |
US5871986A (en) | 1994-09-23 | 1999-02-16 | The General Hospital Corporation | Use of a baculovirus to express and exogenous gene in a mammalian cell |
ATE340866T1 (de) | 1994-10-28 | 2006-10-15 | Gen Probe Inc | Zusammensetzungen und verfahren für die gleichzeitige detektion und quantifizierung von einer mehrheit spezifischer nuklein säure sequenzen |
US5736524A (en) | 1994-11-14 | 1998-04-07 | Merck & Co.,. Inc. | Polynucleotide tuberculosis vaccine |
US5935825A (en) | 1994-11-18 | 1999-08-10 | Shimadzu Corporation | Process and reagent for amplifying nucleic acid sequences |
US5599302A (en) | 1995-01-09 | 1997-02-04 | Medi-Ject Corporation | Medical injection system and method, gas spring thereof and launching device using gas spring |
US5866337A (en) | 1995-03-24 | 1999-02-02 | The Trustees Of Columbia University In The City Of New York | Method to detect mutations in a nucleic acid using a hybridization-ligation procedure |
IE80468B1 (en) | 1995-04-04 | 1998-07-29 | Elan Corp Plc | Controlled release biodegradable nanoparticles containing insulin |
US5843650A (en) | 1995-05-01 | 1998-12-01 | Segev; David | Nucleic acid detection and amplification by chemical linkage of oligonucleotides |
US5916779A (en) | 1995-09-21 | 1999-06-29 | Becton, Dickinson And Company | Strand displacement amplification of RNA targets |
AU713661B2 (en) | 1995-09-29 | 1999-12-09 | Immunex Corporation | Chemokine inhibitor |
US5866331A (en) | 1995-10-20 | 1999-02-02 | University Of Massachusetts | Single molecule detection by in situ hybridization |
US5780448A (en) | 1995-11-07 | 1998-07-14 | Ottawa Civic Hospital Loeb Research | DNA-based vaccination of fish |
DE19541450C2 (de) | 1995-11-07 | 1997-10-02 | Gsf Forschungszentrum Umwelt | Genkonstrukt und dessen Verwendung |
US5789166A (en) | 1995-12-08 | 1998-08-04 | Stratagene | Circular site-directed mutagenesis |
US5612473A (en) | 1996-01-16 | 1997-03-18 | Gull Laboratories | Methods, kits and solutions for preparing sample material for nucleic acid amplification |
US5851772A (en) | 1996-01-29 | 1998-12-22 | University Of Chicago | Microchip method for the enrichment of specific DNA sequences |
US5739169A (en) | 1996-05-31 | 1998-04-14 | Procept, Incorporated | Aromatic compounds for inhibiting immune response |
US5912124A (en) | 1996-06-14 | 1999-06-15 | Sarnoff Corporation | Padlock probe detection |
US5939291A (en) | 1996-06-14 | 1999-08-17 | Sarnoff Corporation | Microfluidic method for nucleic acid amplification |
US5853990A (en) | 1996-07-26 | 1998-12-29 | Edward E. Winger | Real time homogeneous nucleotide assay |
CA2744096C (en) | 1996-07-31 | 2013-07-30 | Laboratory Corporation Of America Holdings | Biomarkers and targets for diagnosis, prognosis and management of prostate disease |
US5945100A (en) | 1996-07-31 | 1999-08-31 | Fbp Corporation | Tumor delivery vehicles |
US5928870A (en) | 1997-06-16 | 1999-07-27 | Exact Laboratories, Inc. | Methods for the detection of loss of heterozygosity |
US5849546A (en) | 1996-09-13 | 1998-12-15 | Epicentre Technologies Corporation | Methods for using mutant RNA polymerases with reduced discrimination between non-canonical and canonical nucleoside triphosphates |
US5981274A (en) | 1996-09-18 | 1999-11-09 | Tyrrell; D. Lorne J. | Recombinant hepatitis virus vectors |
US5853992A (en) | 1996-10-04 | 1998-12-29 | The Regents Of The University Of California | Cyanine dyes with high-absorbance cross section as donor chromophores in energy transfer labels |
US5853993A (en) | 1996-10-21 | 1998-12-29 | Hewlett-Packard Company | Signal enhancement method and kit |
US5900481A (en) | 1996-11-06 | 1999-05-04 | Sequenom, Inc. | Bead linkers for immobilizing nucleic acids to solid supports |
US5905024A (en) | 1996-12-17 | 1999-05-18 | University Of Chicago | Method for performing site-specific affinity fractionation for use in DNA sequencing |
US5846225A (en) | 1997-02-19 | 1998-12-08 | Cornell Research Foundation, Inc. | Gene transfer therapy delivery device and method |
ATE323170T1 (de) | 1997-02-21 | 2006-04-15 | Oxxon Therapeutics Ltd | Rekombinantes pockenvirus das das lösliche chemokine-bindende protein kodierende gen a41l nicht exprimieren kann. |
US5846729A (en) | 1997-02-27 | 1998-12-08 | Lorne Park Research, Inc. | Assaying nucleotides in solution using a fluorescent intensity quenching effect |
US5849497A (en) | 1997-04-03 | 1998-12-15 | The Research Foundation Of State University Of New York | Specific inhibition of the polymerase chain reaction using a non-extendable oligonucleotide blocker |
US5827311A (en) * | 1997-05-08 | 1998-10-27 | Biomet Inc | Carpal tunnel tome |
US5846726A (en) | 1997-05-13 | 1998-12-08 | Becton, Dickinson And Company | Detection of nucleic acids by fluorescence quenching |
US5919626A (en) | 1997-06-06 | 1999-07-06 | Orchid Bio Computer, Inc. | Attachment of unmodified nucleic acids to silanized solid phase surfaces |
US5866366A (en) | 1997-07-01 | 1999-02-02 | Smithkline Beecham Corporation | gidB |
US5916776A (en) | 1997-08-27 | 1999-06-29 | Sarnoff Corporation | Amplification method for a polynucleotide |
ES2292207T3 (es) | 1997-10-09 | 2008-03-01 | Wellstat Biologics Corporation | Tratamiento de neoplasmas con virus clonales, sensibles al interferon. |
US20030044384A1 (en) | 1997-10-09 | 2003-03-06 | Pro-Virus, Inc. | Treatment of neoplasms with viruses |
US5994624A (en) | 1997-10-20 | 1999-11-30 | Cotton Incorporated | In planta method for the production of transgenic plants |
US6177076B1 (en) | 1997-12-09 | 2001-01-23 | Thomas Jefferson University | Method of treating bladder cancer with wild type vaccinia virus |
US6528054B1 (en) * | 1998-12-28 | 2003-03-04 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of breast cancer |
JP2003530301A (ja) | 1999-04-15 | 2003-10-14 | ウェルスタット バイオロジクス コーポレイション | ウイルスを用いた新生物の処置 |
AU5446700A (en) | 1999-05-28 | 2000-12-18 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | A combined growth factor-deleted and thymidine kinase-deleted vaccinia virus vector |
EP1227828A1 (en) | 1999-11-12 | 2002-08-07 | Oncolytics Biotech, Inc. | Viruses for the treatment of cellular proliferative disorders |
US20020048777A1 (en) | 1999-12-06 | 2002-04-25 | Shujath Ali | Method of diagnosing monitoring, staging, imaging and treating prostate cancer |
WO2001060156A1 (en) | 2000-02-14 | 2001-08-23 | Gary R. Davis, M.D., L.L.C. | Neutralizing antibody and immunomodulatory enhancing compositions |
US20040091995A1 (en) | 2001-06-15 | 2004-05-13 | Jeffrey Schlom | Recombinant non-replicating virus expressing gm-csf and uses thereof to enhance immune responses |
DE10134955C1 (de) | 2001-07-23 | 2003-03-06 | Infineon Technologies Ag | Anordnung von Gräben in einem Halbleitersubstrat, insbesondere für Grabenkondensatoren |
US20030206886A1 (en) * | 2002-05-03 | 2003-11-06 | University Of Medicine & Dentistry Of New Jersey | Neutralization of immune suppressive factors for the immunotherapy of cancer |
EP1578396A4 (en) | 2002-08-12 | 2007-01-17 | David Kirn | METHODS AND COMPOSITIONS RELATING TO POXVIRUS AND CANCER |
CN1279056C (zh) | 2003-06-06 | 2006-10-11 | 马菁 | 肿瘤相关抗原sm5-1的特异性抗体及其应用 |
BRPI0411526A (pt) | 2003-06-18 | 2006-08-01 | Genelux Corp | vìrus de vaccinia e outros microrganismos recombinates modificados e usos dos mesmos |
US20050207974A1 (en) | 2004-03-17 | 2005-09-22 | Deng David X | Endothelial cell markers and related reagents and methods of use thereof |
KR101772375B1 (ko) | 2005-09-07 | 2017-08-29 | 신라젠(주) | Gm-csf를 발현하는 폭스바이러스를 사용한 전이성 및/또는 전신 파종성 암의 전신 치료법 |
GB0519303D0 (en) | 2005-09-21 | 2005-11-02 | Oxford Biomedica Ltd | Chemo-immunotherapy method |
EP2073823A1 (en) | 2006-10-13 | 2009-07-01 | Medigene AG | Use of oncolytic viruses and antiangiogenic agents in the treatment of cancer |
WO2008100292A2 (en) | 2006-10-16 | 2008-08-21 | Genelux Corporation | Modified vaccinia virus strains for use in diagnostic and therapeutic methods |
EP1914242A1 (en) | 2006-10-19 | 2008-04-23 | Sanofi-Aventis | Novel anti-CD38 antibodies for the treatment of cancer |
KR20080084528A (ko) | 2007-03-15 | 2008-09-19 | 제네렉스 바이오테라퓨틱스 인크. | 종양살상형 백시니아 바이러스 암 치료 |
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US20160038548A1 (en) | 2016-02-11 |
US20080286237A1 (en) | 2008-11-20 |
US9827278B2 (en) | 2017-11-28 |
KR20090004839A (ko) | 2009-01-12 |
KR101772375B1 (ko) | 2017-08-29 |
US20070065411A1 (en) | 2007-03-22 |
WO2007030668A3 (en) | 2007-07-19 |
KR20140036333A (ko) | 2014-03-25 |
CA2621982A1 (en) | 2007-03-15 |
WO2007030668A2 (en) | 2007-03-15 |
AU2006287441B2 (en) | 2012-09-06 |
CA2621982C (en) | 2017-11-28 |
EP1933857A2 (en) | 2008-06-25 |
JP2013189456A (ja) | 2013-09-26 |
US9180149B2 (en) | 2015-11-10 |
JP2009507853A (ja) | 2009-02-26 |
CN101351213A (zh) | 2009-01-21 |
AU2006287441A1 (en) | 2007-03-15 |
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