CN101312655B - 新颖的稳定的类胡萝卜素组合物 - Google Patents

新颖的稳定的类胡萝卜素组合物 Download PDF

Info

Publication number
CN101312655B
CN101312655B CN2006800265171A CN200680026517A CN101312655B CN 101312655 B CN101312655 B CN 101312655B CN 2006800265171 A CN2006800265171 A CN 2006800265171A CN 200680026517 A CN200680026517 A CN 200680026517A CN 101312655 B CN101312655 B CN 101312655B
Authority
CN
China
Prior art keywords
composition
carotenoid
matrix
starch
soluble antioxidant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN2006800265171A
Other languages
English (en)
Other versions
CN101312655A (zh
Inventor
卡尔·曼弗雷德·沃勒科
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DSM IP Assets BV
Original Assignee
DSM IP Assets BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DSM IP Assets BV filed Critical DSM IP Assets BV
Publication of CN101312655A publication Critical patent/CN101312655A/zh
Application granted granted Critical
Publication of CN101312655B publication Critical patent/CN101312655B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/174—Vitamins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/179—Colouring agents, e.g. pigmenting or dyeing agents
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
    • A23L29/206—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin
    • A23L29/212—Starch; Modified starch; Starch derivatives, e.g. esters or ethers
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
    • A23L29/206—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin
    • A23L29/25—Exudates, e.g. gum arabic, gum acacia, gum karaya or tragacanth
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
    • A23L29/35—Degradation products of starch, e.g. hydrolysates, dextrins; Enzymatically modified starches
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A23L33/155—Vitamins A or D
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L5/00—Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
    • A23L5/40—Colouring or decolouring of foods
    • A23L5/42—Addition of dyes or pigments, e.g. in combination with optical brighteners
    • A23L5/43—Addition of dyes or pigments, e.g. in combination with optical brighteners using naturally occurring organic dyes or pigments, their artificial duplicates or their derivatives
    • A23L5/44—Addition of dyes or pigments, e.g. in combination with optical brighteners using naturally occurring organic dyes or pigments, their artificial duplicates or their derivatives using carotenoids or xanthophylls
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/01—Hydrocarbons
    • A61K31/015—Hydrocarbons carbocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/31—Hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/732—Starch; Amylose; Amylopectin; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B61/00—Dyes of natural origin prepared from natural sources, e.g. vegetable sources
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B67/00—Influencing the physical, e.g. the dyeing or printing properties of dyestuffs without chemical reactions, e.g. by treating with solvents grinding or grinding assistants, coating of pigments or dyes; Process features in the making of dyestuff preparations; Dyestuff preparations of a special physical nature, e.g. tablets, films
    • C09B67/0071—Process features in the making of dyestuff preparations; Dehydrating agents; Dispersing agents; Dustfree compositions
    • C09B67/0084—Dispersions of dyes
    • C09B67/0085—Non common dispersing agents
    • C09B67/0089—Non common dispersing agents non ionic dispersing agent, e.g. EO or PO addition products
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/42—Colour properties
    • A61K2800/43—Pigments; Dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/52—Stabilizers
    • A61K2800/522—Antioxidants; Radical scavengers

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Nutrition Science (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Birds (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Husbandry (AREA)
  • Zoology (AREA)
  • Mycology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Fodder In General (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)

Abstract

本发明涉及含有精细分散的类胡萝卜素的新颖组合物。本发明的新颖组合物能够被用作食物、饮料、动物饲料、化妆品或药物的着色剂或添加剂。着色剂组合物可以是液体或固体组合物。固体组合物包含至少一种被分散于基质中的类胡萝卜素，其中所述基质含有至少一种碳水化合物和/或一种被修饰的碳水化合物和可选的蛋白质、被修饰的蛋白质或其混合物，其中所述至少一种碳水化合物和/或一种被修饰的碳水化合物是淀粉或改性淀粉，其中所述淀粉或改性淀粉的用量是基质总重量的10wt.％到60wt.％，其中所述至少一种类胡萝卜素的浓度是组合物总重量的至少2％。优选使用β-胡萝卜素作为可在水中分散的固体着色剂组合物。

Description

新颖的稳定的类胡萝卜素组合物
本发明涉及含有精细分散的类胡萝卜素的新颖组合物。本发明的新颖组合物能够被用作食物、饮料、动物饲料、化妆品或药物的着色剂或添加剂。 
着色剂组合物可以是液体或固体组合物。优选使用β-胡萝卜素作为可在水中分散的固体着色剂组合物。液体着色剂组合物可以是β-胡萝卜素的稳定水分散体系。为了获得中等彩色色相(hue)，这些组合物可选地含有另一着色化合物，例如另一类胡萝卜素，如β-玉米胡萝卜素(β-zeacarotene)、角黄素、8′-脱-β-胡萝卜素醛、8′-脱-β-类胡萝卜素酸乙酯、番茄红素、虾青素、叶黄素和玉米黄素。 
可在水中分散的固体着色剂组合物是其中β-胡萝卜素精细地分散于基质或载体中的组合物。基质或载体可以是常规用于配制类胡萝卜素的任何基质或载体。例如，载体可以是碳水化合物、经修饰的碳水化合物、蛋白质、经修饰的蛋白质或其混合物。 
用于本发明的这类着色剂组合物的制备可以以本身已知的用于制备食品和饮料中使用的类胡萝卜和脂溶性维生素组合物的方式完成，例如如欧洲专利公开号0 347 751、0 966 889、1066 761、1 106 174和国际专利申请WO 98/15195中所公开的，这些专利文献内容通过参考并入本文。 
制备本发明着色剂组合物的优选步骤是制备β-胡萝卜素和油溶性抗氧化剂在甘油和可选的有机溶剂(例如氯化烃)中的溶液，并在水性溶液中将油性溶液乳化，如果需要，则例如通过蒸发去除有机溶剂，所述水性溶液制备自保护性的水胶体载体如蛋白质、多肽或经修饰的多糖或其混合物、碳水化合物和任选的水溶性抗氧化剂。 
这样获得的水包油分散体系可以使用常规技术被转化为固体组合物例如干粉，所述常规技术如喷雾干燥、喷雾干燥结合流化床造粒(后一技术通常已知为流化喷雾干燥或FSD)，或粉末捕获(powder-catch)技术，所述 粉末捕获技术中喷雾出的乳剂微滴被吸收剂(如淀粉)床捕获并随后干燥。 
公知的固体着色剂组合物以约1wt.％的含量含有β-胡萝卜素并具有橙色色度(shade)。这类组合物可在水中分散，并在食物、饮料、动物饲料、化妆品或药物中产生黄色色度。出于经济原因考虑，提高可在水中分散的该类型组合物中类胡萝卜素的浓度会是有利的。因此，本发明的一个目的是提出一种新的可在水中分散的着色剂组合物，其具有相当的色度但是具有提高的类胡萝卜素浓度。 
通常已知用于饮料中的着色剂组合物应具有高的色彩亮度(colorintensity)以及相对高的浑浊度(turbidity)。我们已出人意料地发现，如果该化合物被用作载体或基质的一部分时，淀粉或改性淀粉含量的变化对色彩亮度和浑浊度、红色值和颗粒尺寸具有影响。还发现通过使用占载体或基质总重量10％到60％的淀粉或改性淀粉，可以将β-胡萝卜素的浓度提高到至少2％、优选2％到10％、更优选2％到5％(根据组合物的总重量计算)，其中最终组合物仍然具有涉及足够的色彩亮度和浑浊度特性。 
因此通过根据权利要求1的着色剂组合物达成本发明的所述目的。 
本发明的有利实施方案由从属权利要求阐明。 
本文使用术语“类胡萝卜素”包括胡萝卜素和结构相关的多烯化合物，其可用作食物、饮料、动物饲料、化妆品或药物的着色剂。这类类胡萝卜素的实例是α-或β-胡萝卜素、8′-脱-β-胡萝卜素醛、8′-脱-β-胡萝卜素酸酯如乙酯、角黄素、虾青素、番茄红素、叶黄素、玉米黄素或藏红花素或其混合物。如已经提到的，优选的类胡萝卜素是β-胡萝卜素。 
存在于本发明组合物中的载体或基质除了食物淀粉或改性食物淀粉(例如辛烯琥珀酰钠淀粉)外，还含有辛烯基丁二酸酯淀粉糊精(octenylbutanedioate amylodextrin，CapsulTM)，多糖胶质如阿拉伯胶，或麦芽糖糊精，或蛋白质如明胶(例如鱼明胶或猪或牛明胶)，或植物蛋白，或乳蛋白或磺酸木质素(ligninsulfonate)或其混合物。 
本发明的新颖组合物还合适地含有佐剂和/或赋形剂，如一种或多种单、双、寡或多糖，甘油三酯，水溶性抗氧化剂，和/或一种或多种脂溶性 抗氧化剂。固体组合物也可含有抗结块剂，如硅酸和水。 
可存在于本发明组合物中的单糖和二糖实例为蔗糖、转化糖、葡萄糖、果糖、乳糖、麦芽糖和糖醇。 
可存在于本发明组合物中的甘油三酯的实例是中等链甘油三酯，植物油如玉米油、葵花子油、大豆油、红花油、油菜籽油、花生油、棕榈油、棕榈仁油、棉籽油或椰子油。 
水溶性抗氧化剂可以是抗坏血酸及其盐，例如抗坏血酸钠等。脂溶性抗氧化剂可以是生育酚，例如dl-α-生育酚(即合成的生育酚)、d-α-生育酚(即天然生育酚)、β-和γ-生育酚及其混合物；丁羟基甲苯、丁基羟基苯甲醚、没食子酸丙酯、t-丁羟基喹啉或脂肪酸的抗坏血酸酯，如抗坏血酸棕榈酸酯或硬脂酸酯。根据水性基质溶液的pH，后两种化合物可以被可选地加入水相中。 
典型地，根据本发明的粉末组合物包含 
-约10到约60wt.％、优选地约20到约30wt.％的糖聚合物，例如麦芽糖糊精； 
-约5到约50wt.％、优选地约10到约40wt.％的阿拉伯胶； 
-约0.2到约10wt.％、优选地约1.5到约10wt.％的类胡萝卜素； 
-5到约15wt.％、优选地约5到约10wt.％的单糖或二糖； 
-10到约50wt.％、优选地约15到约50wt.％的淀粉和改性淀粉； 
-约5到约50wt.％、优选地约10到约20wt.％的甘油三酯； 
-0到约5％、优选地约0.1到约2wt.％的水溶性抗氧化剂； 
-0到约5％、优选地约0.01到约1wt.％的脂溶性抗氧化剂； 
-0到约2wt.％优选地约0.1到约1wt.％的硅酸；和 
-0到约10wt.％、优选地约1到约5wt.％的水； 
所有成分的百分比总计为100。 
本发明的新颖组合物可用作食物、饮料、动物饲料、化妆品或药物的着色剂。通过本发明，优选地提供包含β-胡萝卜素作为着色剂的组合物。其中β-胡萝卜素可以被用作着色剂的饮料可以是碳酸饮料(例如调味的苏打水)、软饮或矿物饮品，以及非碳酸饮料，例如调味的水、果汁、混合 果汁(fruit punches)和这些饮料的浓缩形式。他们可以基于天然水果汁或蔬菜汁或基于人造香料。还包括酒精饮料和方便饮料粉。此外还包括含糖的饮料，无热量的含人造甜味剂的健康饮料。 
另外，得自天然来源或合成来源的乳制品属于食品的范围，其中根据本发明的组合物可以被用作着色剂。这类产物的典型实例是乳饮品、冰激凌、乳酪、酸乳等。乳替代产品如酸乳饮品和豆腐产品也包含在本申请的范围内。 
本发明的新颖组合物也可用作甜食产品、糖果、口香糖、甜点(例如冰激凌、果冻、布丁、方便布丁粉)等等以及谷物、小吃、曲奇、意大利面、汤和沙司、蛋黄酱、沙拉酱等等的着色剂。 
为了对食物或药物产品着色，本发明的组合物可根据本身已知的方法以可分散于水或油的固体或液体类胡萝卜素形式被应用。 
通常，β-胡萝卜素着色剂组合物可作为水性储存溶液、干粉混合物被添加，或根据特定的应用与其他合适的食品成分预混合。根据最终应用的配方，可例如使用干粉搅拌机、低剪力混合机、高压匀化器或高剪力混合机来完成混合。混合方法和油性成分或水性成分的用量可影响最终应用的颜色。显而易见地，这类技术属于本领域技术人员的技能范围之内。 
以下的实施例进一步阐述本发明。 
实施例1：含β-胡萝卜素的着色剂组合物的物理特征对以Capsul和阿拉伯胶混合物为基础的CapsulTM(淀粉衍生物)含量的依赖性 
典型地，用于本发明用途的粉末组合物对应于494nm的色彩亮度E11在1300到1900范围内，优选地在1350到1600范围内，以NTU测量的浑浊度在70到250NTU的范围内，优选地在70到120NTU的范围内。 
在本发明一个优选的实施方案中，粉末组合物包含以Capsul和阿拉伯胶混合物计约25wt.％到约80wt.％、优选地60wt.％到80wt.％的CapsulTM。 
实施例2：着色剂组合物的制备
a)溶液A的制备： 
在80℃下，向1.5升反应管中530g去离子水中加入80.8g阿拉伯胶和244.7g改性淀粉(CapsulTM)的干燥预混合物。在惰性气氛中72℃下搅拌混合物，并将水性溶液的pH保持在约3.9。固体完全溶解后，向混合物中加入7.2g抗坏血酸钠、43.4g蔗糖和175.0g麦芽糖糊精DE-2023。 
b)溶液B的制备： 
向反应烧瓶中加入144.6g的中等链甘油三酯(Berg+Schmidt的Bergabest MCT-Oil 60/40)和0.72g的dl-α-生育酚。在惰性气氛中，加入25.3g的晶体β-胡萝卜素和磁性搅拌棒。柔和地搅拌悬浮液，同时加热至170℃。将混合物在该温度下保持60秒后将混合物再次冷却至85℃。 
c)乳剂的制备： 
在强力搅拌下，在72℃向溶液A中加入溶液B，并将乳剂强力搅拌约15到20分钟。通过将前乳剂在50/300bar的压强下三次高压匀化处理(APV-La 1000匀化器)获得精细的乳剂。 
d)喷雾干燥： 
向乳剂中加入0.2wt.％的硅酸(Aerosil 200)，然后在65℃下在实验室喷雾干燥器中将乳剂喷雾干燥约1小时，使用约200℃的入口温度和约80℃的出口温度。在真空烘箱中室温下将喷雾干燥的粉末干燥过夜。 
e)分析： 
通过光子相关光谱学(Coulter N4 Plus)测量的前乳剂的平均颗粒尺寸约 为500-600nm，通过分光光度法和HPLC分析测定的粉末的β-胡萝卜素含量为2.9％。根据CIE-体系针对5ppm分散体系测量的色值L*＝87.6、a*＝-8、b*＝54。根据a*和b*的值，可以计算出饱和度c*＝55下的色相角h*＝82°。 
*)Copenhagen果胶A/S的GENU果胶型VIS 
根据上述制备法的组合物特征如下： 
    物质     含量wt.％
    晶体抗坏血酸钠     1.0
    蔗糖     6.0
    麦芽糖糊精DE-2023**     24.2
    Capsul**     33.8
    阿拉伯胶**(GA)     11.2
    MCT中等链甘油三酯     20.0
    dl-α-生育酚     0.10
    β-胡萝卜素     3.5
    Aerosil 200     0.20
   
    基质中的％Capsul     48.8
    GA+Capsul中的％Capsul     75.1
   
    分析数据  
    UV/％     2.9
    HPLC/％     2.9
    E11对应/494nm     1642
    E11对应/463nm     1732
    L*/a*/b*-5ppm     87/8/54
    L*/c*/h*-5ppm     87/55/82
    浑浊度/NTU-5ppm     117
**基质 
实施例3：根据上述步骤制备的其他两种组合物(2，3)与本发明范围之外的组合物(对照)比较：
    物质     对照    含量wt.％     2)    含量wt.％     3)    含量wt.％
    晶体抗坏血酸钠     1.0     1.0     1.0
    蔗糖     7.0     7.0     6.0
    麦芽糖糊精DE-    2023**     39.9     28.9     28.9
    Capsul**     0.0     11.0     30.0
    阿拉伯胶**(GA)     33.0     33.0     15.0
    MCT     15.3     15.3     15.3
    dl-α-生育酚     0.1     0.1     0.1
    β-胡萝卜素晶体     3.5     3.5     3.5
    Aerosil 200     0.2     0.2     0.2
       
    基质中的％Capsul     0.0     15.1     40.6
    GA+Capsul中的％    Capsul     0.0     25.0     66.7
       
    分析数据      
    UV/％     3.5     3.2     3.2
    HPLC/％     35     3.1     3.3
    E11对应/494nm     1282     1392     1518
    E11对应/463nm     1196     1435     1714
    L*/a*/b*-5ppm     88/10/44     88/9/55     88/7/66
    L*/c*/h*-5ppm     88/45/77     88/56/81     88/66/84
  红色值％     18     14     10
  浑浊度/NTU-5ppm     125     104     71
**基质 

Claims (8)

1.包含分散于基质中的类胡萝卜素的着色剂组合物，其中所述基质含有改性淀粉，特征是所述组合物包含
-10到60wt.％的糖聚合物；
-5到50wt.％的阿拉伯胶；
-0.2到10wt.％的类胡萝卜素；
-5到10wt.％的单糖或二糖；
-10到20wt.％的甘油三酯；
-0.1到2wt.％的水溶性抗氧化剂；
-0.01到1wt.％的脂溶性抗氧化剂；
-0.1到1wt.％的硅酸；和
-1到5wt.％的水，并且其中
所述基质的改性淀粉包含以辛烯基丁二酸酯淀粉糊精和阿拉伯胶的混合物为基础25wt.％到80wt.％用量的辛烯基丁二酸酯淀粉糊精，足以为着色剂组合物赋予在1300到1900范围内的对应于494nm的色彩亮度和70到250NTU的浊度。
2.如权利要求1所述的组合物，其中所述类胡萝卜素是β-胡萝卜素。
3.如权利要求1或2中所述的组合物，其中所述甘油三酯是衍生自脂肪酸的具有6到12个碳原子的中等链甘油三酯。
4.如权利要求1到3中任一项所述的组合物，其中所述脂溶性抗氧化剂是生育酚或脂肪酸酯或其混合物。
5.如权利要求4所述的组合物，其中所述水溶性抗氧化剂是抗坏血酸。
6.如权利要求1到5中任一项所述的组合物，其为粉末。
7.如权利要求1到6中任一项所述的组合物，其包含：
a)20到30wt.％的麦芽糖糊精；
b)10到40wt.％的阿拉伯胶；
c)1.5到10wt.％的类胡萝卜素。
8.含有如权利要求1到7中任一项所述的组合物的食物、饮料、动物饲料、化妆品或药物。
CN2006800265171A 2005-07-20 2006-07-06 新颖的稳定的类胡萝卜素组合物 Active CN101312655B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP05015734.6 2005-07-20
EP05015734 2005-07-20
PCT/EP2006/006580 WO2007009601A1 (en) 2005-07-20 2006-07-06 Novel stabilized carotenoid compositions

Publications (2)

Publication Number Publication Date
CN101312655A CN101312655A (zh) 2008-11-26
CN101312655B true CN101312655B (zh) 2012-02-29

Family

ID=36866333

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2006800265171A Active CN101312655B (zh) 2005-07-20 2006-07-06 新颖的稳定的类胡萝卜素组合物

Country Status (8)

Country Link
US (2) US20080193539A1 (zh)
EP (2) EP1903887A1 (zh)
JP (1) JP2009501534A (zh)
KR (1) KR101411072B1 (zh)
CN (1) CN101312655B (zh)
IN (1) IN2008DE00463A (zh)
TW (1) TWI402316B (zh)
WO (1) WO2007009601A1 (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015003536A1 (zh) 2013-07-09 2015-01-15 浙江新维普添加剂有限公司 油分散性类胡萝卜素制剂的制备方法

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2394108T3 (es) * 2006-02-06 2013-01-21 Dsm Ip Assets B.V. Composiciones que contienen beta-caroteno
TW200738227A (en) 2006-04-03 2007-10-16 Panatoz Corp One kind of multi-carotenoids and its administration
WO2008087140A2 (de) 2007-01-16 2008-07-24 Basf Se Flüssige formulierungen enthaltend ein carotinoid
EP1964479B1 (en) * 2007-02-14 2013-05-15 DSM IP Assets B.V. Process for the manufacture of a powder containing carotenoids
WO2008102019A2 (de) * 2007-02-23 2008-08-28 Basf Se Verwendung von wasserdispergierbaren carotinoid-nanopartikeln als geschmacksmodulatoren, geschmacksmodulatoren, enthaltend wasserdispergierbare carotinoid-nanopartikel, und verfahren zur geschmacksmodulation
WO2008102018A2 (de) * 2007-02-23 2008-08-28 Basf Se Verfahren zur geschmacksmodulation von stofflichen zusammensetzungen, die mindestens einen high intensity sweetener (his) enthalten
EP1967081A1 (en) * 2007-03-05 2008-09-10 DSMIP Assets B.V. Process for the manufacture of a powder containing carotenoids
WO2008110225A1 (en) * 2007-03-15 2008-09-18 Dsm Ip Assets B.V. Carotenoid compositions containing modified gum acacia
EP2011835A1 (en) 2007-07-06 2009-01-07 Chr. Hansen A/S A colouring composition comprising starch derivatives as a hydrocolloid
JP2010533667A (ja) * 2007-07-19 2010-10-28 ディーエスエム アイピー アセッツ ビー．ブイ． 錠剤化可能な親油性健康成分の配合物
JP5150176B2 (ja) * 2007-09-07 2013-02-20 富士フイルム株式会社 粉末組成物
CN105077203A (zh) * 2007-11-29 2015-11-25 巴斯夫欧洲公司 用于饮料着色的粉状类胡萝卜素制剂
ES2436167T3 (es) * 2008-06-03 2013-12-27 Dsm Ip Assets B.V. Composiciones de ingredientes activos liposolubles que contienen goma ghatti.
ES2563640T5 (es) † 2008-10-07 2021-11-22 Basf Se Emulsión estable, lista para usar
EP2192160B1 (de) * 2008-12-01 2016-08-17 Aquanova Ag Micellar integrierter Oxidationsschutz für natürliche Farbstoffe
CA2745378C (en) * 2008-12-08 2013-07-16 Hill's Pet Nutrition, Inc. Precoagulation, prehydration, and pregelatinization process for pet food composition
US8802079B2 (en) 2008-12-19 2014-08-12 Chr. Hansen A/S Bile resistant Bacillus composition
DK2385766T4 (da) 2009-01-07 2022-05-23 Oterra As Sammensætning, der omfatter calciumcarbonat som et hvidt pigment
JP5680275B2 (ja) * 2009-01-20 2015-03-04 富士フイルム株式会社 エマルション組成物、該エマルション組成物を含む食品及び化粧品
US20120259023A1 (en) * 2009-10-02 2012-10-11 Andrea Hitzfeld Novel plant gum-modified food starch conjugate as emulsifying agent for fat soluble ingredients
WO2011049556A1 (en) * 2009-10-20 2011-04-28 Nestec S.A. Antioxidant containing liquid creamers
JP5600513B2 (ja) * 2010-07-29 2014-10-01 理研ビタミン株式会社 クロセチン製剤の製造方法
KR20130125773A (ko) * 2010-11-03 2013-11-19 디에스엠 아이피 어셋츠 비.브이. 옥테닐 숙시네이트 무수물-개질된 아라비아 고무를 함유하는 카로테노이드 조성물
CN103379893A (zh) * 2011-03-30 2013-10-30 富士胶片株式会社 含类胡萝卜素的组合物及其制造方法
WO2012168189A1 (en) 2011-06-06 2012-12-13 Chr. Hansen A/S Carotenoid coloring composition
EP2644041A1 (en) * 2012-03-30 2013-10-02 DSM IP Assets B.V. Clear liquid carotenoid formulations and clear beverages containing them
EP2687103B1 (en) 2012-07-20 2019-05-22 Basf Se Process for manufacturing an aqueous transparent oil-in-water emulsion comprising a carotenoid and emulsion produced
AU2013311059B2 (en) * 2012-08-26 2017-04-06 Lycored Ltd. Hue-controlled beta-carotene formulations
WO2014191556A1 (en) * 2013-05-30 2014-12-04 Chr. Hansen A/S Method for coloring powders for preparing foods
DE202013006887U1 (de) * 2013-08-01 2013-08-29 Symrise Ag Feste Farbstoffzubereitungen
JP2016533766A (ja) * 2013-09-24 2016-11-04 ディーエスエム アイピー アセッツ ビー．ブイ． 飲料および食品の着色用の安定した赤色製剤
US20160227827A1 (en) * 2013-09-24 2016-08-11 Dsm Ip Assets B.V. Red colorant for beverages, food and pharmaceutical compositions
CA2983545C (en) * 2015-04-28 2023-08-01 Chr. Hansen Natural Colors A/S Water-dispersible coloring composition
JP6462482B2 (ja) * 2015-04-30 2019-01-30 クラシエフーズ株式会社 可食性ペイント組成物用粉末及びそれを用いた組合せ菓子
US20160316792A1 (en) * 2015-04-30 2016-11-03 Rhodes International, Inc. Topical crust colorant
EP3683798B1 (en) * 2015-05-12 2023-12-20 Dexcom, Inc. Distributed system architecture for continuous glucose monitoring
EP3103352A1 (en) * 2015-06-12 2016-12-14 DSM IP Assets B.V. Acid stable beverages comprising bixin
EP3307086A1 (en) * 2015-06-12 2018-04-18 DSM IP Assets B.V. New natural color for edible coatings
US10479906B2 (en) * 2015-09-18 2019-11-19 Oregon State University Use of fungal pigments from wood-staining fungi as colorants in wood finishes and paints
JP7388608B2 (ja) * 2016-04-01 2023-11-29 ディーエスエム アイピー アセッツ ビー．ブイ． ルテインおよび／またはゼアキサンチンの新規の錠剤化可能な製剤
ES2811378T3 (es) * 2016-04-01 2021-03-11 Dsm Ip Assets Bv Bebidas que comprenden gránulos estables de luteína molida
EP3490579A1 (en) 2016-07-27 2019-06-05 Hartis-Pharma SA Therapeutic combinations to treat red blood cell disorders
JP6890878B2 (ja) * 2016-08-19 2021-06-18 日清オイリオグループ株式会社 緑色食品用退色抑制剤
USD806351S1 (en) 2016-09-06 2018-01-02 Mars, Incorporated Food product
USD805728S1 (en) 2016-09-06 2017-12-26 Mars, Incorporated Food product
GB201701417D0 (en) 2017-01-27 2017-03-15 Mars Inc Pet food
WO2019096879A1 (en) * 2017-11-15 2019-05-23 Dsm Ip Assets B.V. Chewing gum
EP3784054A1 (en) * 2018-04-27 2021-03-03 DSM IP Assets B.V. Powderous composition comprising carotenoid and/or derivative thereof, d-glycose oligomers and modified polysaccharide as well as food, feed or personal care formulation comprising the composition
CN109156827A (zh) * 2018-09-20 2019-01-08 武汉星辰现代生物工程有限公司 一种高生物利用度红色系β-胡萝卜素制剂的制备方法
AU2020365042A1 (en) * 2019-10-11 2022-04-07 Dsm Ip Assets B.V. New feed additives of carotenoids
AU2020361549A1 (en) * 2019-10-11 2022-04-07 Dsm Ip Assets B.V. New feed additives of fat-soluble vitamins
CN111471317B (zh) * 2020-03-26 2021-06-04 广东省农业科学院蚕业与农产品加工研究所 一种稳态化玉米黄色素及其制备方法
WO2022129433A1 (en) * 2020-12-18 2022-06-23 Dsm Ip Assets B.V. Milk replacer comprising animal-free formulations of fat-soluble vitamins

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1535115A (zh) * 2001-08-13 2004-10-06 ����˹������ά�ǹɷݹ�˾ 含糖用甜菜果胶和类胡萝卜素的组合物

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1035319B (de) * 1952-05-07 1958-07-31 Hoffmann La Roche Verfahren zur Herstellung eines vitaminhaltigen Pulvers
US3998753A (en) * 1974-08-13 1976-12-21 Hoffmann-La Roche Inc. Water dispersible carotenoid preparations and processes thereof
JPS573861A (en) * 1980-06-11 1982-01-09 Sumitomo Chem Co Ltd Preparation of carotenoid pharmaceutical
JPS61501078A (ja) * 1984-01-31 1986-05-29 ダーキー　インダストリアル　フーヅ　コーポレーション カプセル化用基剤組成物及びこれを含むカプセル化物
US4713251A (en) * 1985-12-18 1987-12-15 Durkee Industrial Foods Corp. Process for encapsulating liquid acids and product
MC2034A1 (fr) 1988-06-23 1990-05-30 Hoffmann La Roche Preparations
DK546289D0 (da) 1989-11-02 1989-11-02 Danochemo As Carotenoidpulvere
US5827539A (en) * 1995-12-28 1998-10-27 Amway Corporation Dry carotenoid-oil powder and process for making same
TW371619B (en) 1996-10-07 1999-10-11 Dsm Ip Assets Bv Vitamin preparations for beverage applications
CA2261456A1 (en) * 1998-02-23 1999-08-23 F. Hoffmann-La Roche Ag Preparation of a finely divided pulverous carotenoid preparation
DE69935946T2 (de) 1998-06-24 2007-09-06 Dsm Ip Assets B.V. Vitaminpulver zur verwendung für getränke
EP1066761B1 (en) 1999-07-06 2004-09-29 DSM IP Assets B.V. Compositions containing fat-soluble substances in a carbohydrate matrix
EP1106174B9 (en) 1999-12-09 2017-05-31 DSM IP Assets B.V. Compositions containing fat-soluble vitamins
DE60008299T2 (de) * 2000-07-13 2004-11-25 Vitatene, S.A. Verfahren zur Herstellung einer wasserdispergierbaren Carotinoid-haltigen Formulierung
MX253134B (es) * 2001-09-13 2008-01-08 Dsm Ip Assets Bv Colorante para alimentos y farmaceuticos.
US6663900B2 (en) * 2002-02-01 2003-12-16 Kemin Foods, Lc Microcapsules having high carotenoid content
CN1662147A (zh) * 2002-04-16 2005-08-31 怀泰斯德美国有限公司 功能性成分的传递系统
JP3662550B2 (ja) * 2002-05-08 2005-06-22 高砂香料工業株式会社 粉末組成物
EP1605917B1 (en) * 2003-03-27 2015-04-22 DSM IP Assets B.V. Process for the production of cross-linked gelatin microbeadlets
DE102004046026A1 (de) * 2004-09-21 2006-03-23 Basf Ag Verfahren zur Herstellung von Trockenpulvern eines oder mehrerer Carotinoide

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1535115A (zh) * 2001-08-13 2004-10-06 ����˹������ά�ǹɷݹ�˾ 含糖用甜菜果胶和类胡萝卜素的组合物

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015003536A1 (zh) 2013-07-09 2015-01-15 浙江新维普添加剂有限公司 油分散性类胡萝卜素制剂的制备方法

Also Published As

Publication number Publication date
EP2272380A1 (en) 2011-01-12
IN2008DE00463A (zh) 2008-08-15
US20080193539A1 (en) 2008-08-14
KR101411072B1 (ko) 2014-06-27
US8912237B2 (en) 2014-12-16
EP1903887A1 (en) 2008-04-02
WO2007009601A1 (en) 2007-01-25
JP2009501534A (ja) 2009-01-22
CN101312655A (zh) 2008-11-26
KR20080031418A (ko) 2008-04-08
TWI402316B (zh) 2013-07-21
US20140018442A1 (en) 2014-01-16
TW200734412A (en) 2007-09-16

Similar Documents

Publication Publication Date Title
CN101312655B (zh) 新颖的稳定的类胡萝卜素组合物
EP2280611B1 (en) Compositions of fat-soluble active ingredients containing gum ghatti
CN101291598B (zh) 具有高生物利用度的脂溶性活性成分的新颖制剂
CA2086847C (en) Stable, liquid products containing fat-soluble substances
EP1981357B1 (en) COMPOSITIONS CONTAINING ß-CAROTENE
JP4351528B2 (ja) 食品及び医薬品のための着色剤
AU2002339495A1 (en) Colorant for food and pharmaceuticals
US20060099301A1 (en) Modified lupin proteins for preparation of water dispersible product forms of fat soluble compounds
CN103188948A (zh) 包含辛烯基琥珀酸酐改性的金合欢胶的类胡萝卜素组合物
CN101378668B (zh) 含β-胡萝卜素的组合物

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant