CN101259122B - 羟油酸及相关化合物在制备药物中的应用 - Google Patents
羟油酸及相关化合物在制备药物中的应用 Download PDFInfo
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- CN101259122B CN101259122B CN2008100917941A CN200810091794A CN101259122B CN 101259122 B CN101259122 B CN 101259122B CN 2008100917941 A CN2008100917941 A CN 2008100917941A CN 200810091794 A CN200810091794 A CN 200810091794A CN 101259122 B CN101259122 B CN 101259122B
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- UWHZIFQPPBDJPM-BQYQJAHWSA-N trans-vaccenic acid Chemical compound CCCCCC\C=C\CCCCCCCCCC(O)=O UWHZIFQPPBDJPM-BQYQJAHWSA-N 0.000 description 1
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Images
Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/201—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having one or two double bonds, e.g. oleic, linoleic acids
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Engineering & Computer Science (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Diabetes (AREA)
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- Obesity (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Vascular Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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| ES200102269A ES2186576B1 (es) | 2001-10-11 | 2001-10-11 | Acido 2-hidroxioleico para utilizar como medicamento. |
| ESP200102269 | 2001-10-11 |
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| CNB028201132A Expired - Lifetime CN100471492C (zh) | 2001-10-11 | 2002-10-09 | 羟油酸及相关化合物在制备药物中的应用 |
| CN2008100917937A Expired - Fee Related CN101259121B (zh) | 2001-10-11 | 2002-10-09 | 羟油酸及相关化合物在制备药物中的应用 |
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| CNB028201132A Expired - Lifetime CN100471492C (zh) | 2001-10-11 | 2002-10-09 | 羟油酸及相关化合物在制备药物中的应用 |
| CN2008100917937A Expired - Fee Related CN101259121B (zh) | 2001-10-11 | 2002-10-09 | 羟油酸及相关化合物在制备药物中的应用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2229935B1 (es) * | 2003-10-10 | 2006-10-01 | Universitat De Les Illes Balears | Utilizacion del acido hidroxioleico y compuestos analagos del mismo como aditivos alimentarios funcionales. |
| JP2009051732A (ja) * | 2005-12-13 | 2009-03-12 | Meiji Seika Kaisha Ltd | Ｐｐａｒリガンド活性を有する組成物 |
| CN101570481B (zh) * | 2008-04-30 | 2012-02-01 | 上海医药工业研究院 | 一种多羟基长链脂肪酸及其分离提取方法和在抑制芳香化酶活性中的应用 |
| ES2342997B1 (es) * | 2008-12-09 | 2011-06-06 | Universitat De Les Illes Balears | Alpha derivados de acidos grasos cis-monoinsaturados para ser usados como medicamento. |
| ES2345241B1 (es) * | 2009-03-16 | 2011-09-08 | Lipopharma Therapeutics | Uso de 2-hidroxiderivados de acidos grasos poliinsaturados como medicamentos. |
| WO2011089265A1 (en) | 2010-01-25 | 2011-07-28 | Bridge Bioresearch Plc | Use of fatty acid compounds for lowering blood glucose levels |
| CN101985420B (zh) * | 2010-01-29 | 2014-04-30 | 苏州润新生物科技有限公司 | 油酸酯及其制备方法和在制备用于治疗高血压及其并发症的药物中的应用 |
| ES2401629B1 (es) * | 2011-10-07 | 2014-03-04 | Universitat De Les Illes Balears | Enantiómeros de 2-hidroxiderivados de ácidos grasos y su uso como medicamentos. |
| JP6053695B2 (ja) * | 2012-01-19 | 2016-12-27 | 日本水産株式会社 | 食欲抑制剤 |
| WO2013132092A1 (en) | 2012-03-09 | 2013-09-12 | Pensieve International Plc | Use of monounsaturated fatty acid compounds for controlling the body weight of a dog or a cat |
| ES2734554T3 (es) * | 2012-09-26 | 2019-12-10 | Tangent Reprofiling Ltd | Combinación de benzo(iso)oxazolpiperidinas con ácido linoleico conjugado |
| GB201217296D0 (en) | 2012-09-27 | 2012-11-14 | Alta Innovations Ltd | Method of treatment and/or prevention |
| RU2679443C2 (ru) * | 2014-10-21 | 2019-02-11 | Университат Де Лес Ильес Балеарс | Способ синтеза гидрокситриглицеридов и их применение для профилактики и лечения заболеваний |
| US10756968B2 (en) | 2015-01-26 | 2020-08-25 | Rapid7, Inc. | Network resource management devices methods and systems |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1118228A (zh) * | 1995-03-16 | 1996-03-13 | 姜训书 | 松籽果酱 |
| CN1291093A (zh) * | 1998-01-21 | 2001-04-11 | 菲德利尼公司 | 可减轻应激、焦虑和进攻性的猪平息信息素 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61297A (ja) * | 1984-06-12 | 1986-01-06 | 日本油脂株式会社 | オレイン酸の製造法 |
| GB8603621D0 (en) * | 1986-02-14 | 1986-03-19 | Habib N | Modifying lipid structure of cell membranes |
| JPS6344843A (ja) * | 1986-08-13 | 1988-02-25 | Kao Corp | 油中水中油型乳化油脂組成物 |
| CN1035925C (zh) * | 1988-11-16 | 1997-09-24 | 许正 | 亲细胞非均质分子脂质的制备方法 |
| US5422371A (en) * | 1992-05-27 | 1995-06-06 | Arch Development Corp. | Methods and compositions for inhibiting 5α-reductase activity |
| CN1118218A (zh) * | 1995-03-16 | 1996-03-13 | 姜训书 | 松籽油的制作方法及松籽保健食用油 |
| GB9506837D0 (en) * | 1995-04-03 | 1995-05-24 | Scotia Holdings Plc | Triglycerides |
| DK0771817T3 (da) * | 1995-10-30 | 2003-07-28 | Oleoyl Estrone Developments S | Oleatmonoestere af østrogener til behandling af obesitet og/eller overvægt |
| US5856537A (en) * | 1996-06-26 | 1999-01-05 | The Scripps Research Institute | Inhibitors of oleamide hydrolase |
| DE19727636C1 (de) * | 1997-06-28 | 1998-11-19 | Rwe Dea Ag | Verfahren zur Herstellung von 2-Alkylcarbonsäuren |
| CN1212867A (zh) * | 1997-09-29 | 1999-04-07 | 宋凤亭 | 防治心脑血管疾病的组合物 |
| US6214875B1 (en) * | 1998-04-14 | 2001-04-10 | Zhenhua Yang | Anticancer effects of specific branched-chain fatty acids and related production process |
| WO1999058120A1 (en) * | 1998-05-08 | 1999-11-18 | Rolf Berge | USE OF NON-β-OXIDIZABLE FATTY ACID ANALOGUES FOR TREATMENT OF SYNDROME-X CONDITIONS |
| GB2389788B (en) * | 2000-12-23 | 2005-07-20 | Univ Creighton | Methods for inducing apoptosis and inhibiting proliferation in cancer cells |
| DE10130491A1 (de) * | 2001-06-25 | 2003-04-17 | Heirler Horst | Verwendung von mittelkettigen Triglyceriden zur Prävention und Therapie von Adipositas |
-
2001
- 2001-10-11 ES ES200102269A patent/ES2186576B1/es not_active Expired - Fee Related
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2002
- 2002-10-09 CN CN2008100917941A patent/CN101259122B/zh not_active Expired - Fee Related
- 2002-10-09 EP EP02783094A patent/EP1435235B1/en not_active Expired - Lifetime
- 2002-10-09 CN CNB028201132A patent/CN100471492C/zh not_active Expired - Lifetime
- 2002-10-09 WO PCT/ES2002/000475 patent/WO2003030891A1/es not_active Ceased
- 2002-10-09 MX MXPA04003255A patent/MXPA04003255A/es active IP Right Grant
- 2002-10-09 JP JP2003533923A patent/JP4737931B2/ja not_active Expired - Lifetime
- 2002-10-09 AT AT02783094T patent/ATE322261T1/de active
- 2002-10-09 US US10/488,726 patent/US20050014831A1/en not_active Abandoned
- 2002-10-09 PT PT02783094T patent/PT1435235E/pt unknown
- 2002-10-09 BR BRPI0213165A patent/BRPI0213165B8/pt not_active IP Right Cessation
- 2002-10-09 ES ES02783094T patent/ES2261752T3/es not_active Expired - Lifetime
- 2002-10-09 RU RU2004114229/15A patent/RU2310445C2/ru active
- 2002-10-09 CA CA2463348A patent/CA2463348C/en not_active Expired - Lifetime
- 2002-10-09 DE DE60210488T patent/DE60210488T2/de not_active Expired - Lifetime
- 2002-10-09 CN CN2008100917937A patent/CN101259121B/zh not_active Expired - Fee Related
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2008
- 2008-04-15 US US12/082,938 patent/US7851507B2/en not_active Expired - Lifetime
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- 2010-11-04 US US12/939,641 patent/US8778995B2/en not_active Expired - Lifetime
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1118228A (zh) * | 1995-03-16 | 1996-03-13 | 姜训书 | 松籽果酱 |
| CN1291093A (zh) * | 1998-01-21 | 2001-04-11 | 菲德利尼公司 | 可减轻应激、焦虑和进攻性的猪平息信息素 |
Non-Patent Citations (3)
| Title |
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| Cardiovascular Diseases16.2006,16第131页右栏第3段,第132页表3. * |
| Eva Warensjo, et al..Fatty acid composition and estimated desaturase activities are associated with obesity and lifestyle variables in men and women.Nutrition, Metabolism & Cardiovascular Diseases16.2006,16第131页右栏第3段，第132页表3. |
| Eva Warensjo, et al..Fatty acid composition and estimated desaturase activities are associated with obesity and lifestyle variables in men and women.Nutrition, Metabolism & * |
Also Published As
| Publication number | Publication date |
|---|---|
| PT1435235E (pt) | 2006-08-31 |
| US20110136906A1 (en) | 2011-06-09 |
| WO2003030891A1 (es) | 2003-04-17 |
| ES2261752T3 (es) | 2006-11-16 |
| ES2186576A1 (es) | 2003-05-01 |
| EP1435235B1 (en) | 2006-04-05 |
| US7851507B2 (en) | 2010-12-14 |
| US20090082446A1 (en) | 2009-03-26 |
| CN1688302A (zh) | 2005-10-26 |
| ES2186576B1 (es) | 2004-09-16 |
| JP4737931B2 (ja) | 2011-08-03 |
| CN101259122A (zh) | 2008-09-10 |
| BRPI0213165B1 (pt) | 2018-01-23 |
| JP2005527479A (ja) | 2005-09-15 |
| CN101259121A (zh) | 2008-09-10 |
| CN100471492C (zh) | 2009-03-25 |
| CA2463348C (en) | 2011-04-05 |
| BR0213165A (pt) | 2004-09-14 |
| EP1435235A1 (en) | 2004-07-07 |
| MXPA04003255A (es) | 2005-01-25 |
| CN101259121B (zh) | 2011-04-06 |
| DE60210488D1 (de) | 2006-05-18 |
| ATE322261T1 (de) | 2006-04-15 |
| US20050014831A1 (en) | 2005-01-20 |
| RU2004114229A (ru) | 2005-04-20 |
| CA2463348A1 (en) | 2003-04-17 |
| DE60210488T2 (de) | 2006-12-14 |
| US8778995B2 (en) | 2014-07-15 |
| RU2310445C2 (ru) | 2007-11-20 |
| BRPI0213165B8 (pt) | 2021-05-25 |
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