CN101193897B - 5-取代的7-氨基-[1，3]噻唑并[4，5-d]嘧啶衍生物 - Google Patents

5-取代的7-氨基-[1，3]噻唑并[4，5-d]嘧啶衍生物 Download PDF

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Publication number
CN101193897B
CN101193897B CN2006800200726A CN200680020072A CN101193897B CN 101193897 B CN101193897 B CN 101193897B CN 2006800200726 A CN2006800200726 A CN 2006800200726A CN 200680020072 A CN200680020072 A CN 200680020072A CN 101193897 B CN101193897 B CN 101193897B
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amino
thiazolo
formula
thio
compound
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CN101193897A (zh
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冈纳·诺得瓦尔
科林·雷
托拜厄斯·赖因
丹尼尔·索恩
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Cancela Joint Stock Co
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AstraZeneca AB
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN2006800200726A 2005-04-06 2006-04-03 5-取代的7-氨基-[1，3]噻唑并[4，5-d]嘧啶衍生物 Active CN101193897B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
SE0500767-9 2005-04-06
SE05007679 2005-04-06
SE0500767 2005-04-06
PCT/SE2006/000399 WO2006107258A1 (en) 2005-04-06 2006-04-03 Novel 5-substituted 7-amino-[1,3]thiazolo[4,5-d]pyrimidine derivatives

Publications (2)

Publication Number Publication Date
CN101193897A CN101193897A (zh) 2008-06-04
CN101193897B true CN101193897B (zh) 2010-12-01

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CN2006800200726A Active CN101193897B (zh) 2005-04-06 2006-04-03 5-取代的7-氨基-[1，3]噻唑并[4，5-d]嘧啶衍生物

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US (2) US7947693B2 (cg-RX-API-DMAC7.html)
EP (1) EP1869056B1 (cg-RX-API-DMAC7.html)
JP (1) JP5165553B2 (cg-RX-API-DMAC7.html)
KR (1) KR101335055B1 (cg-RX-API-DMAC7.html)
CN (1) CN101193897B (cg-RX-API-DMAC7.html)
AR (1) AR055890A1 (cg-RX-API-DMAC7.html)
AT (1) ATE487727T1 (cg-RX-API-DMAC7.html)
AU (1) AU2006231836B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0609738A2 (cg-RX-API-DMAC7.html)
CA (1) CA2604017C (cg-RX-API-DMAC7.html)
CY (1) CY1111316T1 (cg-RX-API-DMAC7.html)
DE (1) DE602006018124D1 (cg-RX-API-DMAC7.html)
DK (1) DK1869056T3 (cg-RX-API-DMAC7.html)
ES (1) ES2354450T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20110047T1 (cg-RX-API-DMAC7.html)
IL (1) IL185912A0 (cg-RX-API-DMAC7.html)
MX (1) MX2007012060A (cg-RX-API-DMAC7.html)
NO (1) NO20075603L (cg-RX-API-DMAC7.html)
NZ (1) NZ561460A (cg-RX-API-DMAC7.html)
PL (1) PL1869056T3 (cg-RX-API-DMAC7.html)
PT (1) PT1869056E (cg-RX-API-DMAC7.html)
RS (1) RS51581B (cg-RX-API-DMAC7.html)
RU (1) RU2419623C2 (cg-RX-API-DMAC7.html)
SA (1) SA06270072B1 (cg-RX-API-DMAC7.html)
SI (1) SI1869056T1 (cg-RX-API-DMAC7.html)
TW (1) TW200714605A (cg-RX-API-DMAC7.html)
UA (1) UA90707C2 (cg-RX-API-DMAC7.html)
UY (1) UY29454A1 (cg-RX-API-DMAC7.html)
WO (1) WO2006107258A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA200708187B (cg-RX-API-DMAC7.html)

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TW200820973A (en) 2006-09-29 2008-05-16 Astrazeneca Ab Novel compounds 480
NZ576519A (en) 2006-09-29 2011-11-25 Astrazeneca Ab Novel 5,7-disubstituted [1, 3] thiazolo [4, 5-d] pyrimidin-2 (3h)-amine derivatives and their use in therapy
SG188177A1 (en) 2008-03-07 2013-03-28 Acraf Novel 1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of mcp-1, cx3cr1 and p40
KR101581829B1 (ko) 2008-03-07 2015-12-31 아지엔드 키미쉐 리유나이트 안젤리니 프란체스코 에이.씨.알.에이.에프. 에스.피.에이 1-벤질-3-하이드록시메틸인다졸 유도체들 및 ｍｃｐ-1 및 ｃｘ3ｃｒ1의 발현을 기초로 한 질환들의 치료에서 이의 용도
PL2262778T3 (pl) 2008-03-07 2020-02-28 Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. Pochodne 1-benzylo-3-hydroksymetyloindazolu i ich zastosowanie w leczeniu chorób opartych na ekspresji MCP-1, CXCR1 i p40
AR076601A1 (es) 2009-05-21 2011-06-22 Chlorion Pharma Inc Pirimidinas como agentes terapeuticos
JO3437B1 (ar) 2009-10-30 2019-10-20 Esai R & D Man Co Ltd أجسام مضادة محسنة مضادة للفراكتالكين البشري واستخداماتها
JP6076913B2 (ja) 2010-12-07 2017-02-08 ドレクセル ユニバーシティ 癌からの転移を阻害する方法
TWI543975B (zh) 2011-09-13 2016-08-01 Eisai R&D Man Co Ltd Pyrrolidin-3-yl acetic acid derivatives
US8476301B2 (en) 2011-09-13 2013-07-02 Eisai R&D Management Co., Ltd. Pyrrolidin-3-ylacetic acid derivative
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JP2016531870A (ja) 2013-09-27 2016-10-13 ニンバス アイリス， インコーポレイテッド Ｉｒａｋ阻害剤およびその使用
WO2016200939A1 (en) * 2015-06-08 2016-12-15 The Johns Hopkins University Radiofluorinated 7-amino-5-thio-thiazolo[4,5-d]pyrimidines for imaging fractalkine receptor (cx3cr1)
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GB201807898D0 (en) * 2018-05-15 2018-06-27 Kancera Ab New processes and products with increased chiral purity
GB201811169D0 (en) * 2018-07-06 2018-08-29 Kancera Ab New compounds
GB202006849D0 (en) 2020-05-08 2020-06-24 Kancera Ab New use
AU2023362450A1 (en) 2022-10-19 2025-05-29 Astrazeneca Ab 2,4,6-trisubstituted 1,3,5-triazines as modulators of cx 3 cr1
WO2025219939A1 (en) 2024-04-17 2025-10-23 Astrazeneca Ab Salts and polymorphs of cx3cr1 modulators
WO2025219947A1 (en) 2024-04-18 2025-10-23 Astrazeneca Ab Thio-substituted 1,3,5-triazine cx3cr1 modulators
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RU2007140551A (ru) 2009-05-20
IL185912A0 (en) 2008-01-06
ATE487727T1 (de) 2010-11-15
WO2006107258A1 (en) 2006-10-12
JP5165553B2 (ja) 2013-03-21
CY1111316T1 (el) 2015-08-05
CN101193897A (zh) 2008-06-04
US7947693B2 (en) 2011-05-24
BRPI0609738A2 (pt) 2011-10-18
EP1869056B1 (en) 2010-11-10
DE602006018124D1 (de) 2010-12-23
RU2419623C2 (ru) 2011-05-27
KR20080004483A (ko) 2008-01-09
EP1869056A4 (en) 2010-02-17
US20110092519A1 (en) 2011-04-21
UA90707C2 (en) 2010-05-25
AU2006231836A1 (en) 2006-10-12
PT1869056E (pt) 2011-01-13
CA2604017A1 (en) 2006-10-12
NZ561460A (en) 2010-12-24
JP2008535835A (ja) 2008-09-04
CA2604017C (en) 2012-03-06
PL1869056T3 (pl) 2011-04-29
DK1869056T3 (da) 2011-02-07
AU2006231836B2 (en) 2010-07-15
MX2007012060A (es) 2007-12-13
AR055890A1 (es) 2007-09-12
TW200714605A (en) 2007-04-16
HRP20110047T1 (hr) 2011-03-31
HK1118556A1 (en) 2009-02-13
RS51581B (sr) 2011-08-31
SA06270072B1 (ar) 2009-02-07
ES2354450T3 (es) 2011-03-15
US9440992B2 (en) 2016-09-13
UY29454A1 (es) 2006-11-30
KR101335055B1 (ko) 2013-12-02
EP1869056A1 (en) 2007-12-26
NO20075603L (no) 2008-01-04
US20080214578A1 (en) 2008-09-04
SI1869056T1 (sl) 2011-02-28
ZA200708187B (en) 2008-11-26

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