CN101171237B - 用于制备任选2-取代的1，6-二氢-6-氧代-4-嘧啶羧酸的方法 - Google Patents

用于制备任选2-取代的1，6-二氢-6-氧代-4-嘧啶羧酸的方法 Download PDF

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Publication number
CN101171237B
CN101171237B CN200680015454XA CN200680015454A CN101171237B CN 101171237 B CN101171237 B CN 101171237B CN 200680015454X A CN200680015454X A CN 200680015454XA CN 200680015454 A CN200680015454 A CN 200680015454A CN 101171237 B CN101171237 B CN 101171237B
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formula
compound
replaces
acid
cyclopropyl
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CN101171237A (zh
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R·夏皮罗
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Kedihua Agricultural Technology Co ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN200680015454XA 2005-05-06 2006-04-28 用于制备任选2-取代的1，6-二氢-6-氧代-4-嘧啶羧酸的方法 Expired - Lifetime CN101171237B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US67826405P 2005-05-06 2005-05-06
US60/678,264 2005-05-06
PCT/US2006/016340 WO2006121648A2 (en) 2005-05-06 2006-04-28 Method for preparation of optionally 2-substituted 1,6-dihydro-6-oxo-4-pyrimidinecarboxylic acids

Related Child Applications (1)

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CN2011100456237A Division CN102153516B (zh) 2005-05-06 2006-04-28 用于制备嘧啶羧酸化合物的中间体

Publications (2)

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CN101171237A CN101171237A (zh) 2008-04-30
CN101171237B true CN101171237B (zh) 2011-04-20

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CN200680015454XA Expired - Lifetime CN101171237B (zh) 2005-05-06 2006-04-28 用于制备任选2-取代的1，6-二氢-6-氧代-4-嘧啶羧酸的方法
CN2011100456237A Expired - Lifetime CN102153516B (zh) 2005-05-06 2006-04-28 用于制备嘧啶羧酸化合物的中间体

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CN2011100456237A Expired - Lifetime CN102153516B (zh) 2005-05-06 2006-04-28 用于制备嘧啶羧酸化合物的中间体

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US (2) US8198442B2 (https=)
EP (1) EP1877384B1 (https=)
JP (1) JP5161764B2 (https=)
KR (1) KR101379967B1 (https=)
CN (2) CN101171237B (https=)
AT (1) ATE506352T1 (https=)
AU (1) AU2006246374B2 (https=)
BR (1) BRPI0612475B8 (https=)
CA (1) CA2607934C (https=)
DE (1) DE602006021411D1 (https=)
DK (1) DK1877384T3 (https=)
EG (1) EG25480A (https=)
ES (1) ES2362005T3 (https=)
GE (1) GEP20105099B (https=)
IL (2) IL185885A (https=)
MA (1) MA29464B1 (https=)
ME (1) ME00498B (https=)
MX (1) MX2007013424A (https=)
NZ (1) NZ561399A (https=)
PL (1) PL1877384T3 (https=)
RS (2) RS51804B (https=)
TN (1) TNSN07403A1 (https=)
UA (1) UA92171C2 (https=)
WO (1) WO2006121648A2 (https=)
ZA (1) ZA200707975B (https=)

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JP5069677B2 (ja) * 2005-05-16 2012-11-07 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー 置換ピリミジンの製造方法
CN101277927A (zh) * 2005-09-29 2008-10-01 帝斯曼知识产权资产管理有限公司 用于酯化有机酸的方法
ES2400405T3 (es) * 2007-08-13 2013-04-09 Dow Agrosciences Llc 2-(Fenil 2-fluoro-substituido)-6-amino-5-cloro-4-pirimidinacarboxilatos y su uso como herbicidas
CA2699598C (en) 2007-10-02 2013-05-21 Dow Agrosciences Llc 2-substituted-6-amino-5-alkyl, alkenyl or alkynyl-4-pyrimidinecarboxylic acids and 6-substituted-4-amino-3-alkyl, alkenyl or alkynyl picolinic acids and their use as herbicides
EP2279178B1 (en) * 2008-04-18 2015-05-20 Dow AgroSciences LLC 2-(substituted phenyl)-6-hydroxy- or alkoxy-5-substituted-4-pyrimidinecarboxylates and their use as herbicides
TWI596088B (zh) * 2011-01-25 2017-08-21 陶氏農業科學公司 ４－胺基－６－（經取代的苯基）吡啶甲酸酯及６－胺基－２－（經取代的苯基）－４－嘧啶羧酸酯之芳烷酯以及其等作為除草劑之用途
ES2561887T3 (es) * 2011-07-27 2016-03-01 Bayer Intellectual Property Gmbh Ácidos picolínicos y piridimin-4-carboxílicos sustituidos, procedimiento para su preparación y su uso como herbicidas y reguladores del crecimiento de plantas
US9113629B2 (en) * 2013-03-15 2015-08-25 Dow Agrosciences Llc 4-amino-6-(4-substituted-phenyl)-picolinates and 6-amino-2-(4-substituted-phenyl)-pyrimidine-4-carboxylates and their use as herbicides
CN110583663A (zh) * 2013-03-15 2019-12-20 美国陶氏益农公司 式(i)化合物及其作为除草剂的用途
US9637505B2 (en) 2013-03-15 2017-05-02 Dow Agrosciences Llc 4-amino-6-(heterocyclic)picolinates and 6-amino-2-(heterocyclic)pyrimidine-4-carboxylates and their use as herbicides
TWI685302B (zh) 2014-09-15 2020-02-21 美商陶氏農業科學公司 包含吡啶羧酸除草劑之安全的除草組成物
TWI689251B (zh) 2014-09-15 2020-04-01 美商陶氏農業科學公司 源自於施用吡啶羧酸除草劑與合成生長素除草劑及/或生長素轉運抑制劑的協同性雜草控制
US10455836B2 (en) 2014-09-15 2019-10-29 Dow Agrosciences Llc Synergistic weed control from applications of pyridine carboxylic acid herbicides and photosystem II inhibitors
TWI694770B (zh) 2014-09-15 2020-06-01 美商陶氏農業科學公司 包含吡啶羧酸除草劑之安全的除草組成物（二）
TWI689252B (zh) 2014-09-15 2020-04-01 美商陶氏農業科學公司 源自於施用吡啶羧酸除草劑與乙醯乳酸合成酶（ａｌｓ）抑制劑的協同性雜草控制
WO2026028053A2 (en) 2024-07-27 2026-02-05 Assia Chemical Industries Ltd. Process for the preparation of tovorafenib

Citations (1)

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US4666915A (en) * 1983-11-05 1987-05-19 Morishita Pharmaceutical Co. Ltd. 2-anilino-1,6-dihydro-6-oxo-5-pyrimidine-carboxylic acid derivatives, process for the preparation thereof, and antiallergic agent containing the same

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CA207185A (en) 1921-01-04 C. Wagner Virgil Warming plate
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JPH0341071A (ja) 1989-07-06 1991-02-21 Morishita Pharmaceut Co Ltd １，６―ジヒドロ―６―オキソ―２―フェノキシアルキルチオ―５―ピリミジンカルボン酸類
DE3935277A1 (de) * 1989-10-24 1991-05-02 Hoechst Ag Sulfonierte heterocyclische carboxamide, verfahren zu ihrer herstellung, sie enthaltende mittel und ihre verwendung als herbizide oder wachstumsregulatoren
US5637618A (en) * 1990-06-01 1997-06-10 Bioresearch, Inc. Specific eatable taste modifiers
DE4029654A1 (de) 1990-09-19 1992-04-02 Hoechst Ag 2-phenyl-pyrimidine, verfahren zu ihrer herstellung, sie enthaltende mittel und ihre verwendung als fungizide
DE4131924A1 (de) * 1991-09-25 1993-07-08 Hoechst Ag Substituierte 4-alkoxypyrimidine, verfahren zu ihrer herstellung und ihre verwendung als schaedlingsbekaempfungsmittel
DE4408404A1 (de) * 1994-03-12 1995-09-14 Huels Chemische Werke Ag Verfahren zur Herstellung von Chlorpyrimidinen
BR9908004A (pt) 1998-02-17 2001-12-18 Tularik Inc Composto, composição e método para prevençãoou supressão de uma infecção viral
US6281358B1 (en) 1999-04-15 2001-08-28 American Cyanamid Company Process for the preparation of substituted pyrimidines
ES2240093T3 (es) 1999-04-15 2005-10-16 Basf Aktiengesellschaft Procedimiento para la preparacion de pirimidinas substituidas.
AU2002258400A1 (en) 2001-02-16 2002-08-28 Tularik Inc. Methods of using pyrimidine-based antiviral agents
DE602004022819D1 (de) 2003-06-06 2009-10-08 Vertex Pharma Von atp-bindende kassette transportern
TWI355894B (en) * 2003-12-19 2012-01-11 Du Pont Herbicidal pyrimidines
EP1849765A4 (en) 2005-02-02 2010-05-05 Ajinomoto Kk PROCESS FOR PREPARING A PYRIMIDINE COMPOUND
DE102005027150A1 (de) 2005-03-12 2006-09-28 Bayer Healthcare Ag Pyrimidincarbonsäure-Derivate und ihre Verwendung
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US4666915A (en) * 1983-11-05 1987-05-19 Morishita Pharmaceutical Co. Ltd. 2-anilino-1,6-dihydro-6-oxo-5-pyrimidine-carboxylic acid derivatives, process for the preparation thereof, and antiallergic agent containing the same

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Title
Daves G. D. et al.Pyrimidines. Ⅱ. Orotic Acid Analogs.《J. Org. Chem.》.1961,第26卷(第8期),2755-2763.
Daves G. D. et al.Pyrimidines. Ⅱ. Orotic Acid Analogs.《J. Org. Chem.》.1961,第26卷(第8期),2755-2763. *
Gershon H..Pyrimidines. Ⅱ. Chlorinated Pyrimidines Derived from OroticAcid.《J. Org. Chem.》.1962,第27卷(第10期),3507-3510. *
徐进宜等.1-取代2-烷基-4-氯-1 6-二氢-6-甲基-5-嘧啶甲酸乙酯类化合物的合成及其降压活性.《中国药科大学学报》.1999
徐进宜等.1-取代2-烷基-4-氯-1, 6-二氢-6-甲基-5-嘧啶甲酸乙酯类化合物的合成及其降压活性.《中国药科大学学报》.1999,第30卷(第6期),406-410. *

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Publication number Publication date
TNSN07403A1 (en) 2009-03-17
EP1877384B1 (en) 2011-04-20
IL222041A (en) 2016-10-31
BRPI0612475A2 (pt) 2010-11-23
DE602006021411D1 (de) 2011-06-01
EG25480A (en) 2012-01-15
MA29464B1 (fr) 2008-05-02
GEP20105099B (en) 2010-10-25
US8198442B2 (en) 2012-06-12
CN102153516B (zh) 2013-02-06
BRPI0612475B8 (pt) 2022-12-06
BRPI0612475B1 (pt) 2020-03-10
CA2607934A1 (en) 2006-11-16
WO2006121648A3 (en) 2006-12-28
JP5161764B2 (ja) 2013-03-13
AU2006246374B2 (en) 2012-03-29
NZ561399A (en) 2009-11-27
ES2362005T3 (es) 2011-06-27
ME00498B (me) 2011-10-10
ATE506352T1 (de) 2011-05-15
ZA200707975B (en) 2008-11-26
JP2008540414A (ja) 2008-11-20
PL1877384T3 (pl) 2011-09-30
RS51804B (sr) 2011-12-31
UA92171C2 (ru) 2010-10-11
US20120232271A1 (en) 2012-09-13
AU2006246374A1 (en) 2006-11-16
KR20080006576A (ko) 2008-01-16
WO2006121648A2 (en) 2006-11-16
MX2007013424A (es) 2008-01-16
CA2607934C (en) 2013-10-01
US20090043098A1 (en) 2009-02-12
DK1877384T3 (da) 2011-08-15
KR101379967B1 (ko) 2014-04-01
IL185885A (en) 2012-10-31
EP1877384A2 (en) 2008-01-16
RS20070434A (sr) 2009-01-22
IL185885A0 (en) 2008-01-06
CN101171237A (zh) 2008-04-30
CN102153516A (zh) 2011-08-17

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Effective date of registration: 20220908

Address after: Indiana, USA

Patentee after: Kedihua Agricultural Technology Co.,Ltd.

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Patentee before: DuPont