CN101090977B - 三肽和四肽硫醚 - Google Patents

三肽和四肽硫醚 Download PDF

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Publication number
CN101090977B
CN101090977B CN2006800014949A CN200680001494A CN101090977B CN 101090977 B CN101090977 B CN 101090977B CN 2006800014949 A CN2006800014949 A CN 2006800014949A CN 200680001494 A CN200680001494 A CN 200680001494A CN 101090977 B CN101090977 B CN 101090977B
Authority
CN
China
Prior art keywords
chemical compound
glutamyl
methyl
phenyl
compound according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN2006800014949A
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English (en)
Chinese (zh)
Other versions
CN101090977A (zh
Inventor
纳塔利娅·奥雷科埃切亚
安德鲁·B·凯尔松
罗伯特·W·毛乔陶
路易丝·鲁滨逊
安东尼·J·桑切斯
尼古拉斯·M·圣地亚哥
史蒂文·R·修
雷纳·J·西蒙
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Telik Inc
Original Assignee
Telik Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Telik Inc filed Critical Telik Inc
Publication of CN101090977A publication Critical patent/CN101090977A/zh
Application granted granted Critical
Publication of CN101090977B publication Critical patent/CN101090977B/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN2006800014949A 2005-01-06 2006-01-04 三肽和四肽硫醚 Expired - Fee Related CN101090977B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US64193205P 2005-01-06 2005-01-06
US60/641,932 2005-01-06
PCT/US2006/000219 WO2006074249A1 (en) 2005-01-06 2006-01-04 Tripeptide and tetrapeptide thioethers

Publications (2)

Publication Number Publication Date
CN101090977A CN101090977A (zh) 2007-12-19
CN101090977B true CN101090977B (zh) 2013-04-10

Family

ID=36123437

Family Applications (2)

Application Number Title Priority Date Filing Date
CN2006800014949A Expired - Fee Related CN101090977B (zh) 2005-01-06 2006-01-04 三肽和四肽硫醚
CNA2006800013664A Pending CN101080418A (zh) 2005-01-06 2006-01-05 三肽砜和四肽砜

Family Applications After (1)

Application Number Title Priority Date Filing Date
CNA2006800013664A Pending CN101080418A (zh) 2005-01-06 2006-01-05 三肽砜和四肽砜

Country Status (24)

Country Link
US (2) US7129215B2 (enExample)
EP (2) EP1833978B1 (enExample)
JP (2) JP4903716B2 (enExample)
KR (2) KR101244609B1 (enExample)
CN (2) CN101090977B (enExample)
AR (2) AR051890A1 (enExample)
AT (2) ATE410520T1 (enExample)
AU (2) AU2006204022B2 (enExample)
BR (2) BRPI0606520A2 (enExample)
CA (2) CA2587284C (enExample)
DE (2) DE602006003064D1 (enExample)
DK (2) DK1833978T3 (enExample)
EA (2) EA200701398A1 (enExample)
ES (2) ES2314890T3 (enExample)
HR (2) HRP20090128T3 (enExample)
IL (2) IL182836A (enExample)
MX (2) MX2007008255A (enExample)
NZ (2) NZ555362A (enExample)
PL (2) PL1833978T3 (enExample)
PT (2) PT1833978E (enExample)
SI (2) SI1833978T1 (enExample)
TW (2) TWI317739B (enExample)
WO (2) WO2006074249A1 (enExample)
ZA (2) ZA200704487B (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8198247B2 (en) * 2004-12-21 2012-06-12 Telik, Inc. Process for and intermediates in the preparation of canfosfamide and its salts
WO2006074249A1 (en) * 2005-01-06 2006-07-13 Telik, Inc. Tripeptide and tetrapeptide thioethers
US20070154963A1 (en) * 2005-12-30 2007-07-05 Danying Cai Method to determine whether a compound is a cellular GSTpi inhibitor
US20090238763A1 (en) 2006-07-09 2009-09-24 Chongxi Yu High penetration compositions and uses thereof
US20090221703A1 (en) 2006-07-09 2009-09-03 Chongxi Yu High penetration composition and uses thereof
AU2006350707A1 (en) 2006-11-08 2008-05-15 Chongxi Yu Transdermal delivery systems of peptides and related compounds
AU2016213759B2 (en) * 2006-11-08 2018-03-29 Chongxi Yu Transdermal delivery systems of peptides and related compounds
KR20210103586A (ko) 2007-06-04 2021-08-23 테크필즈 인크 매우 높은 피부 및 막 침투율을 가지는 비스테로이드성 소염제(ｎｓａｉａ) 약물전구체 및 이들의 새로운 의약적 용도
CN107320732B (zh) 2008-12-04 2021-09-07 于崇曦 高穿透性组合物及其应用
DE102008060888A1 (de) 2008-12-09 2010-06-10 Evonik Stockhausen Gmbh Verfahren zur Herstellung von Acrolein umfassend die Aufarbeitung einer Rohglycerin-Phase
CN109232716A (zh) 2009-05-08 2019-01-18 上海泰飞尔生化技术有限公司 多肽和多肽相关化合物的高穿透力前药组合物
WO2011156045A2 (en) * 2010-06-07 2011-12-15 Telik, Inc. Tablet formulation of ezatiostat
CN102939300A (zh) 2010-06-07 2013-02-20 泰立克公司 无溶剂化晶体依泽替米贝盐酸盐d型的制备
US20130035389A1 (en) * 2011-08-05 2013-02-07 Telik, Inc. Methods for treating myelodysplastic syndrome with ezatiostat
JP5970439B2 (ja) * 2013-09-20 2016-08-17 チョンシー ユー ペプチド及び関連化合物の経皮送達システム
CN106146616A (zh) * 2015-04-03 2016-11-23 浙江海正药业股份有限公司 环肽类化合物及其制备和用途

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995008563A1 (en) * 1993-09-24 1995-03-30 Terrapin Technologies, Inc. Glutathione analogs and paralog panels comprising glutathione mimics
WO1998009986A1 (en) * 1996-09-02 1998-03-12 The Manchester Metropolitan University S-blocked glutathiones

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5599903A (en) * 1992-04-03 1997-02-04 Terrapin Technologies, Inc. Glutathione analogs and paralog panels comprising glutathione mimics
US5556942A (en) 1991-04-29 1996-09-17 Terrapin Technologies, Inc. Glutathione S-transferase-activated compounds
US5767086A (en) * 1992-04-03 1998-06-16 Terrapin Technologies, Inc. Bone marrow stimulation by certain glutathione analogs
US5955432A (en) * 1992-04-03 1999-09-21 Terrapin Technologies, Inc. Metabolic effects of certain glutathione analogs
CA2105492C (en) 1993-09-03 2000-02-01 Lawrence M. Kauvar Glutathione analogs and paralog panels comprising glutathione mimics
US5908919A (en) * 1993-10-01 1999-06-01 Terrapin Technologies Urethane mediated, GST specific molecular release systems
ATE280582T1 (de) 1995-06-07 2004-11-15 Telik Inc Stoffwechseleffekt von bestimmten glutation analogen
EP1072608B1 (en) * 1998-04-16 2005-06-15 Teijin Limited Glutathione derivatives and dosage forms thereof
EP1143992B1 (en) 1999-01-27 2005-01-12 Telik, Inc. Therapeutic compositions containing glutathione analogs
US7029695B2 (en) * 2001-07-10 2006-04-18 Telik, Inc. Therapeutic compositions containing glutathione analogs
TWI323662B (en) * 2002-11-15 2010-04-21 Telik Inc Combination cancer therapy with a gst-activated anticancer compound and another anticancer therapy
WO2006074249A1 (en) 2005-01-06 2006-07-13 Telik, Inc. Tripeptide and tetrapeptide thioethers

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995008563A1 (en) * 1993-09-24 1995-03-30 Terrapin Technologies, Inc. Glutathione analogs and paralog panels comprising glutathione mimics
WO1998009986A1 (en) * 1996-09-02 1998-03-12 The Manchester Metropolitan University S-blocked glutathiones

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ROBERT VINCE等.Studies on the Inhibition of Glyoxalase I by S-Substituted Glutathiones.《Journal of Medicinal Chemistry》.1971,第14卷(第5期),全文. *

Also Published As

Publication number Publication date
ATE410440T1 (de) 2008-10-15
CA2587284A1 (en) 2006-07-13
WO2006074409A1 (en) 2006-07-13
US7129215B2 (en) 2006-10-31
MX2007008255A (es) 2007-09-11
NZ555362A (en) 2009-05-31
SI1833978T1 (sl) 2009-04-30
BRPI0606396A2 (pt) 2009-06-23
JP4903717B2 (ja) 2012-03-28
CA2587310A1 (en) 2006-07-13
TW200635949A (en) 2006-10-16
PT1833842E (pt) 2008-12-11
IL182836A0 (en) 2007-08-19
TWI317739B (en) 2009-12-01
WO2006074249A1 (en) 2006-07-13
SI1833842T1 (sl) 2009-04-30
ES2314891T3 (es) 2009-03-16
IL182836A (en) 2010-11-30
AU2006204022B2 (en) 2011-01-20
EP1833842B1 (en) 2008-10-08
AU2006204022A1 (en) 2006-07-13
EP1833978B1 (en) 2008-10-08
TW200635948A (en) 2006-10-16
KR20070104391A (ko) 2007-10-25
US20060148719A1 (en) 2006-07-06
MX2007008254A (es) 2007-09-11
US7192918B2 (en) 2007-03-20
EP1833842A1 (en) 2007-09-19
BRPI0606520A2 (pt) 2009-06-30
NZ555361A (en) 2009-05-31
US20060160749A1 (en) 2006-07-20
DK1833978T3 (da) 2009-02-09
DK1833842T3 (da) 2009-02-09
JP2008526880A (ja) 2008-07-24
HK1106796A1 (en) 2008-03-20
PT1833978E (pt) 2008-12-02
AR051890A1 (es) 2007-02-14
IL183107A0 (en) 2007-09-20
ES2314890T3 (es) 2009-03-16
HK1106778A1 (en) 2008-03-20
JP4903716B2 (ja) 2012-03-28
DE602006003063D1 (de) 2008-11-20
PL1833842T3 (pl) 2009-04-30
DE602006003064D1 (en) 2008-11-20
ZA200704487B (en) 2008-09-25
WO2006074409A9 (en) 2006-12-14
CN101090977A (zh) 2007-12-19
ZA200704488B (en) 2008-09-25
CN101080418A (zh) 2007-11-28
AU2006203901B2 (en) 2011-06-02
EP1833978A1 (en) 2007-09-19
AU2006203901A1 (en) 2006-07-13
EA200701398A1 (ru) 2007-12-28
EA200701399A1 (ru) 2008-02-28
HRP20090128T3 (hr) 2009-04-30
AR051889A1 (es) 2007-02-14
KR101244609B1 (ko) 2013-03-25
IL183107A (en) 2010-11-30
TWI317738B (en) 2009-12-01
JP2008526859A (ja) 2008-07-24
CA2587310C (en) 2013-11-12
CA2587284C (en) 2014-03-25
PL1833978T3 (pl) 2009-04-30
ATE410520T1 (de) 2008-10-15
KR20070091611A (ko) 2007-09-11
HRP20090134T3 (hr) 2009-04-30

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Granted publication date: 20130410

Termination date: 20150104

EXPY Termination of patent right or utility model