CN101035563B - 包括聚合物部分的多价vla-4拮抗剂 - Google Patents
包括聚合物部分的多价vla-4拮抗剂 Download PDFInfo
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- CN101035563B CN101035563B CN2005800298537A CN200580029853A CN101035563B CN 101035563 B CN101035563 B CN 101035563B CN 2005800298537 A CN2005800298537 A CN 2005800298537A CN 200580029853 A CN200580029853 A CN 200580029853A CN 101035563 B CN101035563 B CN 101035563B
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- Prior art keywords
- substituted
- alkyl
- conjugate
- chemical compound
- polymer moieties
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- 0 CC(C*CC1C(S(C)C)=O)N1S(C1[Al]C1)(=O)=O Chemical compound CC(C*CC1C(S(C)C)=O)N1S(C1[Al]C1)(=O)=O 0.000 description 12
- CVQHSXPTARJNDG-UHFFFAOYSA-N CCC(C)(COC)OCCOC(C)CCNC(NCCC(C)(C)OCCC(C)(C)N)=O Chemical compound CCC(C)(COC)OCCOC(C)CCNC(NCCC(C)(C)OCCC(C)(C)N)=O CVQHSXPTARJNDG-UHFFFAOYSA-N 0.000 description 1
- JYNOZRWOLNYVCN-UHFFFAOYSA-N CCC(CCOC(C)CCNC(OC(COCCOC(C)CCOC)=N)=O)N Chemical compound CCC(CCOC(C)CCNC(OC(COCCOC(C)CCOC)=N)=O)N JYNOZRWOLNYVCN-UHFFFAOYSA-N 0.000 description 1
- FPEPRRGVRQSZEF-MHZLTWQESA-N CCN(CC)c(nc1N[C@@H](Cc(cc2)ccc2N(c(nccc2)c2N2)C2=O)C(OC(C)(C)C)=O)ncc1N(CC)C(c1ccncc1)=O Chemical compound CCN(CC)c(nc1N[C@@H](Cc(cc2)ccc2N(c(nccc2)c2N2)C2=O)C(OC(C)(C)C)=O)ncc1N(CC)C(c1ccncc1)=O FPEPRRGVRQSZEF-MHZLTWQESA-N 0.000 description 1
- LHGMCUVJFRBVBH-UHFFFAOYSA-N Nc(cncn1)c1Cl Chemical compound Nc(cncn1)c1Cl LHGMCUVJFRBVBH-UHFFFAOYSA-N 0.000 description 1
Classifications
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Virology (AREA)
- Oncology (AREA)
- Endocrinology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Physical Education & Sports Medicine (AREA)
- Vascular Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Otolaryngology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US58697504P | 2004-07-08 | 2004-07-08 | |
US60/586,975 | 2004-07-08 | ||
PCT/US2005/024369 WO2006010054A2 (en) | 2004-07-08 | 2005-07-08 | Multivalent vla-4 antagonists comprising polyethylene glycol moieties |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101035563A CN101035563A (zh) | 2007-09-12 |
CN101035563B true CN101035563B (zh) | 2012-03-28 |
Family
ID=35501261
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2005800298537A Expired - Fee Related CN101035563B (zh) | 2004-07-08 | 2005-07-08 | 包括聚合物部分的多价vla-4拮抗剂 |
Country Status (20)
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4754693B2 (ja) * | 1999-01-22 | 2011-08-24 | エラン ファーマシューティカルズ,インコーポレイテッド | Vla−4関連障害を処置するアシル誘導体 |
CA2554188A1 (en) * | 2004-01-23 | 2005-08-04 | Elan Pharmaceuticals, Inc. | Polyethylene glycol conjugates of heterocycloalkyl carboxamido propanoic acids |
EP2258400A3 (en) | 2004-07-08 | 2011-08-10 | Elan Pharmaceuticals, Inc. | Multivalent VLA-4 antagonists comprising polymer moieties |
AU2006251620B8 (en) * | 2005-05-20 | 2013-07-18 | Elan Pharmaceuticals, Inc. | Imidazolone phenylalanine derivatives as VLA-4 antagonists |
EP1901778A2 (en) * | 2005-07-08 | 2008-03-26 | Elan Pharmaceuticals Inc. | Preparation of polymer conjugates of therapeutic, agricultural, and food additive compounds |
DK1940826T3 (da) * | 2005-09-29 | 2011-04-18 | Elan Pharm Inc | Pyrimidinylamidforbindelser, der inhiberer leukocytadhæsion medieret gennem BLA-4 |
AU2006297180A1 (en) * | 2005-09-29 | 2007-04-12 | Elan Pharmaceuticals, Inc. | Carbamate compounds which inhibit leukocyte adhesion mediated by VLA-4 |
US20090111828A1 (en) * | 2005-11-23 | 2009-04-30 | Astrazeneca Ab | L-alanine derivatives |
EA017110B1 (ru) * | 2006-02-27 | 2012-09-28 | Элан Фамэсьютикэлс, Инк. | ПИРИМИДИНИЛСУЛЬФОНАМИДНЫЕ СОЕДИНЕНИЯ (ВАРИАНТЫ), СПОСОБ ПОЛУЧЕНИЯ ПИРИМИДИНИЛСУЛЬФОНАМИДНЫХ СОЕДИНЕНИЙ (ВАРИАНТЫ), ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СПОСОБ ЛЕЧЕНИЯ ЗАБОЛЕВАНИЯ, ОПОСРЕДОВАННОГО ИНТЕГРИНОМ α4, СПОСОБ СНИЖЕНИЯ И/ИЛИ ПРЕДУПРЕЖДЕНИЯ ВОСПАЛИТЕЛЬНОГО КОМПОНЕНТА ЗАБОЛЕВАНИЯ ИЛИ АУТОИММУННОГО ОТВЕТА |
JP2009531304A (ja) * | 2006-02-28 | 2009-09-03 | エラン ファーマシューティカルズ,インコーポレイテッド | α−4阻害剤化合物を用いて炎症性疾患および自己免疫疾患を治療する方法 |
HUE047230T2 (hu) * | 2006-02-28 | 2020-04-28 | Biogen Ma Inc | Gyulladásos és autoimmun betegségek natalizumabbal való kezelésének módszerei |
EP1991267B1 (en) | 2006-03-03 | 2017-12-20 | Biogen MA Inc. | Methods of treating inflammatory and autoimmune diseases with natalizumab |
BRPI0712013A2 (pt) * | 2006-05-22 | 2011-12-27 | Elan Pharm Inc | preparaÇço de conjugados polimÉricos de compostos terapÊuticos, agrÍcolas e aditivos alimentares |
JP2009539815A (ja) * | 2006-06-09 | 2009-11-19 | アストラゼネカ アクチボラグ | 固形腫瘍の治療用のa5b1アンタゴニストとしてのN−(ベンゾイル)−O−[2−(ピリジン−2−イルアミノ)エチル]−L−チロシン誘導体と関連化合物 |
WO2008093065A1 (en) * | 2007-01-29 | 2008-08-07 | Astrazeneca Ab | L-ALANINE DERIVATIVES AS α5βL ANTAGONISTS |
US20100150915A1 (en) | 2007-02-20 | 2010-06-17 | Stewart Edward J | Methods of treating multiple sclerosis by administration of alpha-fetoprotein in combination with an integrin antagonist |
WO2008125811A1 (en) * | 2007-04-11 | 2008-10-23 | Astrazeneca Ab | N-[HETEROARYLCARBONYL]-S-THIENYL-L-ALANINE DERIVATIVES AS α5β1 ANTAGONISTS |
WO2008153967A1 (en) * | 2007-06-08 | 2008-12-18 | Contec Therapeutics, Inc. | Bk1 antagonist conjugates |
US8269009B2 (en) * | 2007-12-07 | 2012-09-18 | Elan Pharmaceuticals, Inc. | Methods and compositions for treating liquid tumors |
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