CN1006390B - 一种硬质医用药物胶囊 - Google Patents
一种硬质医用药物胶囊Info
- Publication number
- CN1006390B CN1006390B CN85106760A CN85106760A CN1006390B CN 1006390 B CN1006390 B CN 1006390B CN 85106760 A CN85106760 A CN 85106760A CN 85106760 A CN85106760 A CN 85106760A CN 1006390 B CN1006390 B CN 1006390B
- Authority
- CN
- China
- Prior art keywords
- cellulose
- ether
- capsule
- hard capsules
- polyvinyl alcohol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000002775 capsule Substances 0.000 title claims abstract description 60
- 239000007902 hard capsule Substances 0.000 claims abstract description 34
- 239000004372 Polyvinyl alcohol Substances 0.000 claims abstract description 30
- 229920002451 polyvinyl alcohol Polymers 0.000 claims abstract description 30
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 14
- 229920002959 polymer blend Polymers 0.000 claims abstract description 8
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 75
- 229920002678 cellulose Polymers 0.000 claims description 37
- 235000010980 cellulose Nutrition 0.000 claims description 37
- 239000001913 cellulose Substances 0.000 claims description 36
- 239000007864 aqueous solution Substances 0.000 claims description 31
- 239000000243 solution Substances 0.000 claims description 27
- 238000000034 method Methods 0.000 claims description 22
- 239000000126 substance Substances 0.000 claims description 14
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims description 13
- 238000001035 drying Methods 0.000 claims description 8
- 238000002360 preparation method Methods 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 6
- 238000007127 saponification reaction Methods 0.000 claims description 6
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 claims description 5
- 229920000609 methyl cellulose Polymers 0.000 claims description 5
- 239000001923 methylcellulose Substances 0.000 claims description 5
- 229920001479 Hydroxyethyl methyl cellulose Polymers 0.000 claims description 4
- 238000006116 polymerization reaction Methods 0.000 claims description 4
- 125000001033 ether group Chemical group 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 2
- 229920013819 hydroxyethyl ethylcellulose Polymers 0.000 claims description 2
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 2
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 2
- 239000004215 Carbon black (E152) Substances 0.000 claims 1
- 229930195733 hydrocarbon Natural products 0.000 claims 1
- 229920000159 gelatin Polymers 0.000 abstract description 33
- 235000019322 gelatine Nutrition 0.000 abstract description 33
- 108010010803 Gelatin Proteins 0.000 abstract description 30
- 239000008273 gelatin Substances 0.000 abstract description 30
- 235000011852 gelatine desserts Nutrition 0.000 abstract description 30
- 239000003814 drug Substances 0.000 abstract description 16
- 239000000463 material Substances 0.000 abstract description 16
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract description 8
- 229910052760 oxygen Inorganic materials 0.000 abstract description 8
- 239000001301 oxygen Substances 0.000 abstract description 8
- 229920003086 cellulose ether Polymers 0.000 abstract description 4
- 229920013820 alkyl cellulose Polymers 0.000 abstract description 3
- -1 e.g. Polymers 0.000 abstract description 3
- 230000035699 permeability Effects 0.000 abstract description 3
- 229920013821 hydroxy alkyl cellulose Polymers 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000007493 shaping process Methods 0.000 abstract 1
- 238000012360 testing method Methods 0.000 description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
- 239000008194 pharmaceutical composition Substances 0.000 description 9
- 229920000642 polymer Polymers 0.000 description 8
- 238000013142 basic testing Methods 0.000 description 6
- 230000008859 change Effects 0.000 description 6
- 238000007654 immersion Methods 0.000 description 6
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 5
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 5
- 239000007787 solid Substances 0.000 description 5
- 229920002472 Starch Polymers 0.000 description 4
- 238000007872 degassing Methods 0.000 description 4
- 230000001066 destructive effect Effects 0.000 description 4
- 230000035939 shock Effects 0.000 description 4
- 239000008107 starch Substances 0.000 description 4
- 239000001828 Gelatine Substances 0.000 description 3
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 3
- 239000008186 active pharmaceutical agent Substances 0.000 description 3
- 239000000284 extract Substances 0.000 description 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 3
- 239000000049 pigment Substances 0.000 description 3
- 235000019698 starch Nutrition 0.000 description 3
- GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 241000209094 Oryza Species 0.000 description 2
- 235000007164 Oryza sativa Nutrition 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 230000000813 microbial effect Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 235000009566 rice Nutrition 0.000 description 2
- 235000019154 vitamin C Nutrition 0.000 description 2
- 239000011718 vitamin C Substances 0.000 description 2
- MEIRRNXMZYDVDW-MQQKCMAXSA-N (2E,4E)-2,4-hexadien-1-ol Chemical compound C\C=C\C=C\CO MEIRRNXMZYDVDW-MQQKCMAXSA-N 0.000 description 1
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 239000004902 Softening Agent Substances 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- DPDMMXDBJGCCQC-UHFFFAOYSA-N [Na].[Cl] Chemical compound [Na].[Cl] DPDMMXDBJGCCQC-UHFFFAOYSA-N 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 229920006243 acrylic copolymer Polymers 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 239000002152 aqueous-organic solution Substances 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 238000005266 casting Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000006837 decompression Effects 0.000 description 1
- 238000007907 direct compression Methods 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 238000013467 fragmentation Methods 0.000 description 1
- 238000006062 fragmentation reaction Methods 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 238000005470 impregnation Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 238000000643 oven drying Methods 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 229920002379 silicone rubber Polymers 0.000 description 1
- 239000004945 silicone rubber Substances 0.000 description 1
- 238000004088 simulation Methods 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 125000000547 substituted alkyl group Chemical group 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 230000004584 weight gain Effects 0.000 description 1
- 235000019786 weight gain Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L1/00—Compositions of cellulose, modified cellulose or cellulose derivatives
- C08L1/08—Cellulose derivatives
- C08L1/26—Cellulose ethers
- C08L1/28—Alkyl ethers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59-222676 | 1984-10-23 | ||
| JP59222676A JPS61100519A (ja) | 1984-10-23 | 1984-10-23 | 医薬用硬質カプセル |
| JP222676/84 | 1984-10-23 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN85106760A CN85106760A (zh) | 1986-04-10 |
| CN1006390B true CN1006390B (zh) | 1990-01-10 |
Family
ID=16786176
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN85106760A Expired CN1006390B (zh) | 1984-10-23 | 1985-09-09 | 一种硬质医用药物胶囊 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US4917885A (enrdf_load_stackoverflow) |
| EP (1) | EP0180287B1 (enrdf_load_stackoverflow) |
| JP (1) | JPS61100519A (enrdf_load_stackoverflow) |
| KR (1) | KR860003006A (enrdf_load_stackoverflow) |
| CN (1) | CN1006390B (enrdf_load_stackoverflow) |
| AU (1) | AU575948B2 (enrdf_load_stackoverflow) |
| CA (1) | CA1256797A (enrdf_load_stackoverflow) |
| DE (1) | DE3580089D1 (enrdf_load_stackoverflow) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR900000254B1 (ko) * | 1986-05-12 | 1990-01-24 | 신에쯔까 가가꾸 고우교우 가부시끼가이샤 | 의약용 경질 캅셀의 제조방법과 그 제조장치 |
| US4801636A (en) * | 1987-03-24 | 1989-01-31 | The Clorox Company | Rinse soluble polymer film composition for wash additives |
| US5264223A (en) * | 1990-03-29 | 1993-11-23 | Japan Elanco Company, Ltd. | Hard capsule for pharmaceutical drugs and method for producing the same |
| US5698155A (en) | 1991-05-31 | 1997-12-16 | Gs Technologies, Inc. | Method for the manufacture of pharmaceutical cellulose capsules |
| CA2113643C (en) * | 1991-07-19 | 2003-04-22 | Ikbal A. Akhtar | Seed film compositions |
| US5272191A (en) * | 1991-08-21 | 1993-12-21 | Fmc Corporation | Cold water soluble films and film forming compositions |
| ATE204750T1 (de) * | 1992-06-12 | 2001-09-15 | Teijin Ltd | Pharmazeutische zubereitung zur anwendung in den atemwegen |
| JP3116602B2 (ja) * | 1992-10-06 | 2000-12-11 | シオノギクオリカプス株式会社 | 硬質カプセル |
| US5431917A (en) * | 1992-10-08 | 1995-07-11 | Japan Elanco Company, Ltd. | Hard capsule for pharmaceutical drugs and method for producing the same |
| JP2959423B2 (ja) | 1994-12-01 | 1999-10-06 | シオノギクオリカプス株式会社 | カプセル用皮膜組成物 |
| US5756123A (en) * | 1994-12-01 | 1998-05-26 | Japan Elanco Co., Ltd. | Capsule shell |
| JPH11510148A (ja) * | 1995-08-02 | 1999-09-07 | ワーナー−ランバート・カンパニー | 水分輸送が低い硬ゼラチンカプセル及びその製造方法 |
| ATE283689T1 (de) * | 1998-09-28 | 2004-12-15 | Warner Lambert Co | Arzneistoffabgabe in den dünndarm und den dickdarm unter verwendung von hpmc-kapseln |
| US6221391B1 (en) * | 1998-11-23 | 2001-04-24 | Accucaps Industries Limited | Self-emulsifying ibuprofen solution and soft gelatin capsule for use therewith |
| JP3572213B2 (ja) * | 1999-01-18 | 2004-09-29 | 信越化学工業株式会社 | 低置換度ヒドロキシプロピルセルロース |
| EP1171471B2 (en) * | 1999-04-01 | 2009-07-08 | Dow Global Technologies Inc. | Enhanced gel strength methylcellulose |
| JP2000327701A (ja) * | 1999-05-18 | 2000-11-28 | Shin Etsu Chem Co Ltd | 低置換度ヒドロキシプロピルセルロース及び固形製剤 |
| GB0005016D0 (en) * | 2000-03-01 | 2000-04-26 | Jumik Technologies Limited | PVA-Containing compositions |
| DE10015662A1 (de) * | 2000-03-29 | 2001-10-04 | Henkel Kgaa | Zahnpflegemittel in Portionskapseln |
| AU4061702A (en) * | 2001-05-15 | 2003-04-03 | Mcneil-Ppc, Inc. | Dip coating compositions containing starch or dextrin |
| US20030070584A1 (en) * | 2001-05-15 | 2003-04-17 | Cynthia Gulian | Dip coating compositions containing cellulose ethers |
| AUPR656201A0 (en) * | 2001-07-24 | 2001-08-16 | R.P. Scherer Holdings Pty Ltd | Non-gelatin shells for capsules |
| MXPA04002976A (es) * | 2001-09-28 | 2005-06-20 | Johnson & Johnson | Formas de dosificacion con un nucleo interior y una cobertura externa. |
| US8309118B2 (en) * | 2001-09-28 | 2012-11-13 | Mcneil-Ppc, Inc. | Film forming compositions containing sucralose |
| US6752953B2 (en) * | 2001-12-03 | 2004-06-22 | Yung Shin Pharmaceutical Co., Ltd. | Method for manufacturing hard non-gelatin pharmaceutical capsules |
| US6958848B2 (en) * | 2002-05-23 | 2005-10-25 | E Ink Corporation | Capsules, materials for use therein and electrophoretic media and displays containing such capsules |
| US7429619B2 (en) * | 2002-08-02 | 2008-09-30 | Mcneil Consumer Healthcare | Polyacrylic film forming compositions |
| US20040043064A1 (en) * | 2002-08-29 | 2004-03-04 | Iorio Theodore L. | Dosage forms having reduced moisture transmission |
| US6981980B2 (en) | 2003-03-19 | 2006-01-03 | Phagia Technology | Self-inflating intragastric volume-occupying device |
| US20060058829A1 (en) * | 2003-03-19 | 2006-03-16 | Sampson Douglas C | Intragastric volume-occupying device |
| JP2005187376A (ja) * | 2003-12-25 | 2005-07-14 | Shin Etsu Chem Co Ltd | 低置換度セルロースエーテル含有カプセル及びその製造方法 |
| CN101052719A (zh) | 2004-10-29 | 2007-10-10 | 国际花卉开发有限公司 | 利用编码花色苷3＇位芳香族酰基转移酶的基因的花色苷色素稳定化和蓝化方法 |
| WO2007086586A1 (en) * | 2006-01-24 | 2007-08-02 | Qualicaps Co., Ltd. | Low-moisture-content hard capsule and production method therefor |
| WO2008018825A1 (en) * | 2006-08-10 | 2008-02-14 | Astrazeneca Ab | Oral polyvinyl alcohol capsules comprising proton pump inhibitors |
| JP5143024B2 (ja) * | 2007-01-12 | 2013-02-13 | クオリカプス株式会社 | 褐色皮膜組成物およびその調製方法 |
| US20080292692A1 (en) * | 2007-05-21 | 2008-11-27 | Shira Pilch | Impermeable Capsules |
| IT1393245B1 (it) * | 2008-07-24 | 2012-04-12 | Universita' Degli Studi Di Milano | Forme farmaceutiche per il rilascio tempo-specifico di farmaci |
| US9072583B2 (en) | 2008-10-16 | 2015-07-07 | Obalon Therapeutics, Inc. | Intragastric volume-occupying device and method for fabricating same |
| CN102369022A (zh) * | 2009-04-03 | 2012-03-07 | 日新化成株式会社 | 硬胶囊 |
| KR101783945B1 (ko) | 2009-05-12 | 2017-10-10 | 비피에스아이 홀딩스, 엘엘씨. | 향상된 수분차단 속방출형 필름의 코팅 시스템 및 이에 의하여 코팅된 기재 |
| TWI531584B (zh) * | 2009-09-02 | 2016-05-01 | 日本曹達股份有限公司 | 含有羥烷基纖維素之被覆劑 |
| KR101184750B1 (ko) * | 2010-12-09 | 2012-09-21 | 주식회사 에코팩 | 폴리비닐알코올 및 셀룰로오스계 고분자를 혼합한 분해도가 조절된 혼합 생분해성 고분자 필름 및 이의 제조방법 |
| CN103282393B (zh) * | 2010-12-22 | 2016-06-01 | 索尔维特殊聚合物意大利有限公司 | 亲水偏二氟乙烯聚合物 |
| US8202291B1 (en) | 2011-01-21 | 2012-06-19 | Obalon Therapeutics, Inc. | Intragastric device |
| MX345691B (es) | 2011-01-21 | 2017-02-10 | Obalon Therapeutics Inc | Dispositivo intragástrico. |
| US8647358B2 (en) | 2011-01-21 | 2014-02-11 | Obalon Therapeutics Inc. | Intragastric device |
| US8292911B2 (en) | 2011-01-21 | 2012-10-23 | Obalon Therapeutics, Inc. | Intragastric device |
| JP6227646B2 (ja) * | 2012-07-23 | 2017-11-08 | ロッテ精密化學株式会社ＬＯＴＴＥ Ｆｉｎｅ Ｃｈｅｍｉｃａｌ Ｃｏ．，Ｌｔｄ． | 硬質カプセル製造用水性組成物及びその製造方法、硬質カプセル、並びに硬質カプセルスクラップの再活用方法 |
| KR20150038212A (ko) | 2012-07-23 | 2015-04-08 | 다우 글로벌 테크놀로지스 엘엘씨 | 경질 캡슐 쉘용 필름 조성물 |
| JP6043693B2 (ja) * | 2012-10-19 | 2016-12-14 | 富士フイルム株式会社 | 保護膜形成用の樹脂組成物、保護膜、パターン形成方法、電子デバイスの製造方法及び電子デバイス |
| KR102085330B1 (ko) | 2012-12-05 | 2020-03-05 | 롯데정밀화학 주식회사 | 두께 균일성이 개선된 경질 캡슐 |
| JP2013231185A (ja) * | 2013-06-12 | 2013-11-14 | Pfizer Products Inc | ヒドロキシプロピルメチルセルロース硬カプセルおよび製造方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR732895A (fr) * | 1932-10-18 | 1932-09-25 | Consortium Elektrochem Ind | Objets filés en alcool polyvinylique |
| GB643853A (en) * | 1946-04-13 | 1950-09-27 | Lilly Co Eli | Medicinal capsules and process of manufacture |
| DE1469840B2 (de) * | 1962-03-05 | 1976-04-01 | Rudolf Reiser, chemische Fabrik, KG, 8500 Nürnberg | Modelliermasse |
| US3528860A (en) * | 1967-10-04 | 1970-09-15 | Oakite Prod Inc | Surface coating compositions and their use |
| FR1605150A (enrdf_load_stackoverflow) * | 1968-12-31 | 1973-03-16 | ||
| CA944689A (en) * | 1970-07-28 | 1974-04-02 | Claude Rene | Capsules en matieres plastiques et leurs procedes de fabrication |
| JPS549473B2 (enrdf_load_stackoverflow) * | 1971-08-18 | 1979-04-24 | ||
| JPS5524110A (en) * | 1978-08-09 | 1980-02-21 | Nippon B C G Seizo Kk | Oral capsules and their preparation |
| ES495811A0 (es) * | 1979-10-13 | 1981-09-16 | Denki Kagaku Kogyo Kk | Un procedimiento para preparar un polimero de un compuesto de vinilo |
-
1984
- 1984-10-23 JP JP59222676A patent/JPS61100519A/ja active Granted
-
1985
- 1985-05-20 EP EP85303533A patent/EP0180287B1/en not_active Expired - Lifetime
- 1985-05-20 DE DE8585303533T patent/DE3580089D1/de not_active Expired - Fee Related
- 1985-05-21 CA CA000481919A patent/CA1256797A/en not_active Expired
- 1985-05-31 AU AU43183/85A patent/AU575948B2/en not_active Ceased
- 1985-09-09 CN CN85106760A patent/CN1006390B/zh not_active Expired
- 1985-10-18 KR KR1019850007695A patent/KR860003006A/ko not_active Ceased
-
1986
- 1986-12-23 US US06/946,119 patent/US4917885A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US4917885A (en) | 1990-04-17 |
| JPH0456007B2 (enrdf_load_stackoverflow) | 1992-09-07 |
| EP0180287A3 (en) | 1987-04-29 |
| KR860003006A (ko) | 1986-05-19 |
| JPS61100519A (ja) | 1986-05-19 |
| CA1256797A (en) | 1989-07-04 |
| EP0180287A2 (en) | 1986-05-07 |
| EP0180287B1 (en) | 1990-10-10 |
| CN85106760A (zh) | 1986-04-10 |
| AU575948B2 (en) | 1988-08-11 |
| DE3580089D1 (de) | 1990-11-15 |
| AU4318385A (en) | 1986-05-01 |
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