CN1006390B - 一种硬质医用药物胶囊 - Google Patents
一种硬质医用药物胶囊Info
- Publication number
- CN1006390B CN1006390B CN85106760A CN85106760A CN1006390B CN 1006390 B CN1006390 B CN 1006390B CN 85106760 A CN85106760 A CN 85106760A CN 85106760 A CN85106760 A CN 85106760A CN 1006390 B CN1006390 B CN 1006390B
- Authority
- CN
- China
- Prior art keywords
- cellulose
- ether
- capsule
- hard capsules
- polyvinyl alcohol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000002775 capsule Substances 0.000 title claims abstract description 60
- 239000007902 hard capsule Substances 0.000 claims abstract description 34
- 239000004372 Polyvinyl alcohol Substances 0.000 claims abstract description 30
- 229920002451 polyvinyl alcohol Polymers 0.000 claims abstract description 30
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 14
- 229920002959 polymer blend Polymers 0.000 claims abstract description 8
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 75
- 229920002678 cellulose Polymers 0.000 claims description 37
- 235000010980 cellulose Nutrition 0.000 claims description 37
- 239000001913 cellulose Substances 0.000 claims description 36
- 239000007864 aqueous solution Substances 0.000 claims description 31
- 239000000243 solution Substances 0.000 claims description 27
- 238000000034 method Methods 0.000 claims description 22
- 239000000126 substance Substances 0.000 claims description 14
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims description 13
- 238000001035 drying Methods 0.000 claims description 8
- 238000002360 preparation method Methods 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 6
- 238000007127 saponification reaction Methods 0.000 claims description 6
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 claims description 5
- 229920000609 methyl cellulose Polymers 0.000 claims description 5
- 239000001923 methylcellulose Substances 0.000 claims description 5
- 229920001479 Hydroxyethyl methyl cellulose Polymers 0.000 claims description 4
- 238000006116 polymerization reaction Methods 0.000 claims description 4
- 125000001033 ether group Chemical group 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 2
- 229920013819 hydroxyethyl ethylcellulose Polymers 0.000 claims description 2
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 2
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 2
- 239000004215 Carbon black (E152) Substances 0.000 claims 1
- 229930195733 hydrocarbon Natural products 0.000 claims 1
- 229920000159 gelatin Polymers 0.000 abstract description 33
- 235000019322 gelatine Nutrition 0.000 abstract description 33
- 108010010803 Gelatin Proteins 0.000 abstract description 30
- 239000008273 gelatin Substances 0.000 abstract description 30
- 235000011852 gelatine desserts Nutrition 0.000 abstract description 30
- 239000003814 drug Substances 0.000 abstract description 16
- 239000000463 material Substances 0.000 abstract description 16
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract description 8
- 229910052760 oxygen Inorganic materials 0.000 abstract description 8
- 239000001301 oxygen Substances 0.000 abstract description 8
- 229920003086 cellulose ether Polymers 0.000 abstract description 4
- 229920013820 alkyl cellulose Polymers 0.000 abstract description 3
- -1 e.g. Polymers 0.000 abstract description 3
- 230000035699 permeability Effects 0.000 abstract description 3
- 229920013821 hydroxy alkyl cellulose Polymers 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000007493 shaping process Methods 0.000 abstract 1
- 238000012360 testing method Methods 0.000 description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
- 239000008194 pharmaceutical composition Substances 0.000 description 9
- 229920000642 polymer Polymers 0.000 description 8
- 238000013142 basic testing Methods 0.000 description 6
- 230000008859 change Effects 0.000 description 6
- 238000007654 immersion Methods 0.000 description 6
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 5
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 5
- 239000007787 solid Substances 0.000 description 5
- 229920002472 Starch Polymers 0.000 description 4
- 238000007872 degassing Methods 0.000 description 4
- 230000001066 destructive effect Effects 0.000 description 4
- 230000035939 shock Effects 0.000 description 4
- 239000008107 starch Substances 0.000 description 4
- 239000001828 Gelatine Substances 0.000 description 3
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 3
- 239000008186 active pharmaceutical agent Substances 0.000 description 3
- 239000000284 extract Substances 0.000 description 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 3
- 239000000049 pigment Substances 0.000 description 3
- 235000019698 starch Nutrition 0.000 description 3
- GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 241000209094 Oryza Species 0.000 description 2
- 235000007164 Oryza sativa Nutrition 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 230000000813 microbial effect Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 235000009566 rice Nutrition 0.000 description 2
- 235000019154 vitamin C Nutrition 0.000 description 2
- 239000011718 vitamin C Substances 0.000 description 2
- MEIRRNXMZYDVDW-MQQKCMAXSA-N (2E,4E)-2,4-hexadien-1-ol Chemical compound C\C=C\C=C\CO MEIRRNXMZYDVDW-MQQKCMAXSA-N 0.000 description 1
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 239000004902 Softening Agent Substances 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- DPDMMXDBJGCCQC-UHFFFAOYSA-N [Na].[Cl] Chemical compound [Na].[Cl] DPDMMXDBJGCCQC-UHFFFAOYSA-N 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 229920006243 acrylic copolymer Polymers 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 239000002152 aqueous-organic solution Substances 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 238000005266 casting Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000006837 decompression Effects 0.000 description 1
- 238000007907 direct compression Methods 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 238000013467 fragmentation Methods 0.000 description 1
- 238000006062 fragmentation reaction Methods 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 238000005470 impregnation Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 238000000643 oven drying Methods 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 229920002379 silicone rubber Polymers 0.000 description 1
- 239000004945 silicone rubber Substances 0.000 description 1
- 238000004088 simulation Methods 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 125000000547 substituted alkyl group Chemical group 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 230000004584 weight gain Effects 0.000 description 1
- 235000019786 weight gain Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L1/00—Compositions of cellulose, modified cellulose or cellulose derivatives
- C08L1/08—Cellulose derivatives
- C08L1/26—Cellulose ethers
- C08L1/28—Alkyl ethers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59222676A JPS61100519A (ja) | 1984-10-23 | 1984-10-23 | 医薬用硬質カプセル |
| JP222676/84 | 1984-10-23 | ||
| JP59-222676 | 1984-10-23 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN85106760A CN85106760A (zh) | 1986-04-10 |
| CN1006390B true CN1006390B (zh) | 1990-01-10 |
Family
ID=16786176
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN85106760A Expired CN1006390B (zh) | 1984-10-23 | 1985-09-09 | 一种硬质医用药物胶囊 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US4917885A (enrdf_load_stackoverflow) |
| EP (1) | EP0180287B1 (enrdf_load_stackoverflow) |
| JP (1) | JPS61100519A (enrdf_load_stackoverflow) |
| KR (1) | KR860003006A (enrdf_load_stackoverflow) |
| CN (1) | CN1006390B (enrdf_load_stackoverflow) |
| AU (1) | AU575948B2 (enrdf_load_stackoverflow) |
| CA (1) | CA1256797A (enrdf_load_stackoverflow) |
| DE (1) | DE3580089D1 (enrdf_load_stackoverflow) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR900000254B1 (ko) * | 1986-05-12 | 1990-01-24 | 신에쯔까 가가꾸 고우교우 가부시끼가이샤 | 의약용 경질 캅셀의 제조방법과 그 제조장치 |
| US4801636A (en) * | 1987-03-24 | 1989-01-31 | The Clorox Company | Rinse soluble polymer film composition for wash additives |
| US5264223A (en) * | 1990-03-29 | 1993-11-23 | Japan Elanco Company, Ltd. | Hard capsule for pharmaceutical drugs and method for producing the same |
| US5698155A (en) * | 1991-05-31 | 1997-12-16 | Gs Technologies, Inc. | Method for the manufacture of pharmaceutical cellulose capsules |
| DK0595894T3 (da) * | 1991-07-19 | 1996-05-13 | Uniroyal Chem Co Inc | Frøfilmsammensætninger |
| US5272191A (en) * | 1991-08-21 | 1993-12-21 | Fmc Corporation | Cold water soluble films and film forming compositions |
| DE69330672T2 (de) * | 1992-06-12 | 2002-06-27 | Teijin Ltd., Osaka | Pharmazeutische zubereitung zur anwendung in den atemwegen |
| JP3116602B2 (ja) * | 1992-10-06 | 2000-12-11 | シオノギクオリカプス株式会社 | 硬質カプセル |
| US5431917A (en) * | 1992-10-08 | 1995-07-11 | Japan Elanco Company, Ltd. | Hard capsule for pharmaceutical drugs and method for producing the same |
| US5756123A (en) * | 1994-12-01 | 1998-05-26 | Japan Elanco Co., Ltd. | Capsule shell |
| JP2959423B2 (ja) | 1994-12-01 | 1999-10-06 | シオノギクオリカプス株式会社 | カプセル用皮膜組成物 |
| JPH11510148A (ja) * | 1995-08-02 | 1999-09-07 | ワーナー−ランバート・カンパニー | 水分輸送が低い硬ゼラチンカプセル及びその製造方法 |
| JP5068401B2 (ja) * | 1998-09-28 | 2012-11-07 | カプスゲル・ベルギウム・ナムローゼ・フェンノートシャップ | Ｈｐｍｃカプセルを使用する腸及び結腸への送達 |
| US6221391B1 (en) * | 1998-11-23 | 2001-04-24 | Accucaps Industries Limited | Self-emulsifying ibuprofen solution and soft gelatin capsule for use therewith |
| JP3572213B2 (ja) * | 1999-01-18 | 2004-09-29 | 信越化学工業株式会社 | 低置換度ヒドロキシプロピルセルロース |
| JP2002541270A (ja) * | 1999-04-01 | 2002-12-03 | ザ ダウ ケミカル カンパニー | 向上したゲル強度のメチルセルロース |
| JP2000327701A (ja) * | 1999-05-18 | 2000-11-28 | Shin Etsu Chem Co Ltd | 低置換度ヒドロキシプロピルセルロース及び固形製剤 |
| GB0005016D0 (en) * | 2000-03-01 | 2000-04-26 | Jumik Technologies Limited | PVA-Containing compositions |
| DE10015662A1 (de) * | 2000-03-29 | 2001-10-04 | Henkel Kgaa | Zahnpflegemittel in Portionskapseln |
| AU4061702A (en) * | 2001-05-15 | 2003-04-03 | Mcneil-Ppc, Inc. | Dip coating compositions containing starch or dextrin |
| US20030070584A1 (en) * | 2001-05-15 | 2003-04-17 | Cynthia Gulian | Dip coating compositions containing cellulose ethers |
| AUPR656201A0 (en) * | 2001-07-24 | 2001-08-16 | R.P. Scherer Holdings Pty Ltd | Non-gelatin shells for capsules |
| CA2461354C (en) * | 2001-09-28 | 2010-04-27 | Mcneil-Ppc, Inc. | Fondant-based pharmaceutical composition |
| US8309118B2 (en) * | 2001-09-28 | 2012-11-13 | Mcneil-Ppc, Inc. | Film forming compositions containing sucralose |
| US6752953B2 (en) * | 2001-12-03 | 2004-06-22 | Yung Shin Pharmaceutical Co., Ltd. | Method for manufacturing hard non-gelatin pharmaceutical capsules |
| US6958848B2 (en) * | 2002-05-23 | 2005-10-25 | E Ink Corporation | Capsules, materials for use therein and electrophoretic media and displays containing such capsules |
| US7429619B2 (en) * | 2002-08-02 | 2008-09-30 | Mcneil Consumer Healthcare | Polyacrylic film forming compositions |
| US20040043064A1 (en) * | 2002-08-29 | 2004-03-04 | Iorio Theodore L. | Dosage forms having reduced moisture transmission |
| US6981980B2 (en) | 2003-03-19 | 2006-01-03 | Phagia Technology | Self-inflating intragastric volume-occupying device |
| US20060058829A1 (en) * | 2003-03-19 | 2006-03-16 | Sampson Douglas C | Intragastric volume-occupying device |
| JP2005187376A (ja) * | 2003-12-25 | 2005-07-14 | Shin Etsu Chem Co Ltd | 低置換度セルロースエーテル含有カプセル及びその製造方法 |
| AU2005297801B2 (en) | 2004-10-29 | 2010-12-16 | Suntory Holdings Limited | Method of stabilizing, and bluing, of anthocyanin pigment using gene coding for transferase of aromatic acyl to 3'-position of anthocyanin |
| US20100233252A1 (en) * | 2006-01-24 | 2010-09-16 | Qualicaps Co., Ltd. | Low-Moisture-Content Hard Capsule and Production Method Therefor |
| WO2008018825A1 (en) * | 2006-08-10 | 2008-02-14 | Astrazeneca Ab | Oral polyvinyl alcohol capsules comprising proton pump inhibitors |
| US20090030091A1 (en) * | 2007-01-12 | 2009-01-29 | Qualicaps Co., Ltd. | Brown Film Composition and Method for Preparing the Same |
| US20080292692A1 (en) * | 2007-05-21 | 2008-11-27 | Shira Pilch | Impermeable Capsules |
| IT1393245B1 (it) * | 2008-07-24 | 2012-04-12 | Universita' Degli Studi Di Milano | Forme farmaceutiche per il rilascio tempo-specifico di farmaci |
| WO2010045482A2 (en) | 2008-10-16 | 2010-04-22 | Obalon Therapeutics, Inc. | Intragastric device |
| JPWO2010114134A1 (ja) * | 2009-04-03 | 2012-10-11 | 日新化成株式会社 | 硬カプセル |
| AU2010248060A1 (en) * | 2009-05-12 | 2011-10-27 | Bpsi Holdings, Llc. | Enhanced moisture barrier immediate release film coating systems and substrates coated therewith |
| HUE035536T2 (en) * | 2009-09-02 | 2018-05-28 | Nippon Soda Co | Coating agent containing hydroxyalkyl cellulose |
| KR101184750B1 (ko) * | 2010-12-09 | 2012-09-21 | 주식회사 에코팩 | 폴리비닐알코올 및 셀룰로오스계 고분자를 혼합한 분해도가 조절된 혼합 생분해성 고분자 필름 및 이의 제조방법 |
| WO2012084580A1 (en) * | 2010-12-22 | 2012-06-28 | Solvay Specialty Polymers Italy S.P.A. | Hydrophilic vinylidene fluoride polymers |
| US8292911B2 (en) | 2011-01-21 | 2012-10-23 | Obalon Therapeutics, Inc. | Intragastric device |
| KR101806089B1 (ko) | 2011-01-21 | 2017-12-07 | 오발론 테라퓨틱스 인코퍼레이티드 | 위내 장치 |
| US8647358B2 (en) | 2011-01-21 | 2014-02-11 | Obalon Therapeutics Inc. | Intragastric device |
| US8202291B1 (en) | 2011-01-21 | 2012-06-19 | Obalon Therapeutics, Inc. | Intragastric device |
| WO2014017756A1 (ko) * | 2012-07-23 | 2014-01-30 | 삼성정밀화학(주) | 경질 캡슐 제조용 수성 조성물, 그의 제조방법, 경질 캡슐 및 경질 캡슐 스크랩의 재활용 방법 |
| WO2014018279A1 (en) | 2012-07-23 | 2014-01-30 | Dow Global Technologies Llc | Film composition for hard capsule shells |
| JP6043693B2 (ja) * | 2012-10-19 | 2016-12-14 | 富士フイルム株式会社 | 保護膜形成用の樹脂組成物、保護膜、パターン形成方法、電子デバイスの製造方法及び電子デバイス |
| KR102085330B1 (ko) | 2012-12-05 | 2020-03-05 | 롯데정밀화학 주식회사 | 두께 균일성이 개선된 경질 캡슐 |
| JP2013231185A (ja) * | 2013-06-12 | 2013-11-14 | Pfizer Products Inc | ヒドロキシプロピルメチルセルロース硬カプセルおよび製造方法 |
| TR201902206T4 (tr) * | 2013-06-17 | 2019-03-21 | Nippon Soda Co | Hidroksialkil selüloz içeren kaplama ajanı. |
| KR20160094397A (ko) | 2013-12-04 | 2016-08-09 | 오발론 테라퓨틱스 인코퍼레이티드 | 위 내 장치를 위치시키고 및/또는 특징화하는 시스템 및 방법 |
| ES2793530T3 (es) * | 2014-05-19 | 2020-11-16 | Tillotts Pharma Ag | Cápsulas revestidas de liberación modificada |
| EP3203916B1 (en) | 2014-10-09 | 2021-12-15 | ReShape Lifesciences Inc. | Ultrasonic systems and methods for locating and /or characterizing intragastric devices |
| BR112017019170A2 (pt) | 2015-03-09 | 2018-07-10 | Intekrin Therapeutics, Inc. | métodos para o tratamento de doença do fígado gorduroso não alcoólico e / ou lipodistrofia |
| CN108472244A (zh) * | 2015-10-09 | 2018-08-31 | 科姆博盖股份有限公司 | 为了改进的生物利用度的具有内部隔片的胶囊 |
| US10335303B2 (en) | 2015-12-07 | 2019-07-02 | Obalon Therapeutics, Inc. | Intragastric device |
| US10537453B2 (en) | 2015-12-16 | 2020-01-21 | Obalon Therapeutics, Inc. | Intragastric device with expandable portions |
| US10350100B2 (en) | 2016-04-12 | 2019-07-16 | Obalon Therapeutics, Inc. | System for detecting an intragastric balloon |
| US10772752B2 (en) | 2016-11-04 | 2020-09-15 | Obalon Therapeutics, Inc. | Pressure control system for intragastric device |
| NZ752946A (en) * | 2016-12-08 | 2025-03-28 | Scherer Technologies Llc R P | A method to relieve stress in capsule shells to reduce propensity to break |
| US11253508B2 (en) | 2017-04-03 | 2022-02-22 | Coherus Biosciences, Inc. | PPARy agonist for treatment of progressive supranuclear palsy |
| KR102086461B1 (ko) * | 2018-01-19 | 2020-03-09 | 주식회사 서흥 | 열겔화 히프로멜로오스 하드 캡슐의 제조방법 |
| JP7165626B2 (ja) * | 2019-06-06 | 2022-11-04 | 信越化学工業株式会社 | インクジェット印刷を行う錠剤向けのコーティング用組成物、これを用いた水性インクによる印字を有する錠剤及びその製造方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR732895A (fr) * | 1932-10-18 | 1932-09-25 | Consortium Elektrochem Ind | Objets filés en alcool polyvinylique |
| GB643853A (en) * | 1946-04-13 | 1950-09-27 | Lilly Co Eli | Medicinal capsules and process of manufacture |
| DE1469840B2 (de) * | 1962-03-05 | 1976-04-01 | Rudolf Reiser, chemische Fabrik, KG, 8500 Nürnberg | Modelliermasse |
| US3528860A (en) * | 1967-10-04 | 1970-09-15 | Oakite Prod Inc | Surface coating compositions and their use |
| FR1605150A (enrdf_load_stackoverflow) * | 1968-12-31 | 1973-03-16 | ||
| CA944689A (en) * | 1970-07-28 | 1974-04-02 | Claude Rene | Capsules en matieres plastiques et leurs procedes de fabrication |
| JPS549473B2 (enrdf_load_stackoverflow) * | 1971-08-18 | 1979-04-24 | ||
| JPS5524110A (en) * | 1978-08-09 | 1980-02-21 | Nippon B C G Seizo Kk | Oral capsules and their preparation |
| US4388442A (en) * | 1979-10-13 | 1983-06-14 | Denki Kagaku Kogyo Kabushiki Kaisha | Stabilizer or dispersing agent for use in a suspension polymerization of a vinyl compound comprising a modified and partially hydrolyzed anionic polyvinyl alcohol |
-
1984
- 1984-10-23 JP JP59222676A patent/JPS61100519A/ja active Granted
-
1985
- 1985-05-20 EP EP85303533A patent/EP0180287B1/en not_active Expired - Lifetime
- 1985-05-20 DE DE8585303533T patent/DE3580089D1/de not_active Expired - Fee Related
- 1985-05-21 CA CA000481919A patent/CA1256797A/en not_active Expired
- 1985-05-31 AU AU43183/85A patent/AU575948B2/en not_active Ceased
- 1985-09-09 CN CN85106760A patent/CN1006390B/zh not_active Expired
- 1985-10-18 KR KR1019850007695A patent/KR860003006A/ko not_active Ceased
-
1986
- 1986-12-23 US US06/946,119 patent/US4917885A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU4318385A (en) | 1986-05-01 |
| DE3580089D1 (de) | 1990-11-15 |
| JPH0456007B2 (enrdf_load_stackoverflow) | 1992-09-07 |
| CA1256797A (en) | 1989-07-04 |
| US4917885A (en) | 1990-04-17 |
| EP0180287B1 (en) | 1990-10-10 |
| CN85106760A (zh) | 1986-04-10 |
| JPS61100519A (ja) | 1986-05-19 |
| AU575948B2 (en) | 1988-08-11 |
| EP0180287A2 (en) | 1986-05-07 |
| EP0180287A3 (en) | 1987-04-29 |
| KR860003006A (ko) | 1986-05-19 |
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