GB643853A - Medicinal capsules and process of manufacture - Google Patents

Medicinal capsules and process of manufacture

Info

Publication number
GB643853A
GB643853A GB30847A GB30847A GB643853A GB 643853 A GB643853 A GB 643853A GB 30847 A GB30847 A GB 30847A GB 30847 A GB30847 A GB 30847A GB 643853 A GB643853 A GB 643853A
Authority
GB
Grant status
Application
Patent type
Prior art keywords
deg
cellulose
capsules
per cent
water
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB30847A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co Ltd (GB)
Original Assignee
Eli Lilly and Co Ltd (GB)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A61J3/071Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816Wall or shell material
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02Making microcapsules or microballoons
    • B01J13/06Making microcapsules or microballoons by phase separation
    • B01J13/08Simple coacervation, i.e. addition of highly hydrophilic material
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J2205/00General identification or selection means
    • A61J2205/20Colour codes

Abstract

A thermo-gelled film of a water-soluble methyl cellulose having a methoxyl content of 25 to 35 per cent and an intrinsic viscosity (based on a 2 per cent solution in distilled water at 20 DEG C.) of 7 to 15 centipoises, is used in the formation of a telescoping medicinal capsule. A methoxy content of 30 per cent and a viscosity of 9 centipoises is preferred. Flexibility is improved and capsules suitable for enclosing hygroscopic medicaments are made by incorporating plasticizers such as invert sugar, sorbitol, mannitol, sucrose, dextrose, monacetin, lactose, triethyl phosphate, glycerol; monoethers of glycerol such as glycerol a -methyl ethers, a - and b -glucoheptonic acid and/or their lactones and lower alkyl and glycol esters, glucono g -lactone, g -valerolactone; a -amino acids, e.g. glycine, ethyl glycinate; amines such as monoethanolamine and triethanolamine; glycols such as propylene glycol, triethylene glycol, 2-ethyl-1,3-hexanediol, 1,3-butylene glycol; glucosides such as a -methyl glucoside; acetopropanol, amides such as acetamide and propionamide. Further there may be present: (a) electrolytes, e.g. benzene sulphonic acid, toluene sulphonic acid and citric acid; (b) colouring materials such as edible dyes of animal or vegetable origin, e.g. carmine, cudbear and caramel, or synthetic dyes, e.g. amaranth, brilliant blue F.C.F., eosin, erythrosine, guinea green certified, orange I, ponceau 3R, sunset yellow F.C.F., and tartrazine; (c) substances rendering the capsules opaque, e.g. charcoal and titanium dioxide; (d) gums, e.g. acacia; (e) wetting agents, e.g. sodium dioctyl sulphosuccinate; (f) non-thermogelling cellulose derivatives, e.g. water-soluble hydroxy ethyl cellulose; (g) Carbowax-a polyethylene glycol. The capsules are formed by dipping highly-polished, stainless steel pins, maintained at, say, 65 DEG C., into a bubble-free aqueous solution of methyl cellulose of suitable viscosity, preferably maintained at 18 DEG C., and gelling should occur within 35 seconds of such contact. The temperature of the pins may be varied over, say, 40 DEG to 80 DEG C., depending upon the size of the capsules and the viscosity of the methyl cellulose employed. Before dipping, the pins are lubricated with, e.g. a mixture of equal parts of anhydrous lanolin and soft soap containing 0.1 per cent by weight of chromium trioxide. After dipping, the coated pins are rotated to facilitate even coating and dried in a kiln through which a current of air is passed, the temperature being maintained at 40 DEG C. for 30 minutes and then slowly raised to 60 DEG C. over a further 15 minutes, such drying preventing brittleness. Infra-red radiation may be used in the drying operation. The Specification as open to inspection under Sect. 91 disclosed that any water-soluble thermogelling etherified cellulose derivative may be used, e.g. ethyl substituted ethers and p methylated cellulose ethers of glycollic acid. This subject-matter does not appear in the Specification as accepted.ALSO:A telescoping medicinal capsule is formed of a thermo-gelled film of a water-soluble methyl cellulose having a methoxy content of 25 to 35 per cent and an intrinsic viscosity (2 per cent solution in distilled water at 20 DEG C) of 7 to 15 centipoises. A methoxy content of 30 per cent and viscosity of 9 centipoises is preferred. Flexibility is improved and capsules suitable for enclosing hydroscopic medicaments are made by incorporating plasticizers such as invert sugar, sorbitol, mannitol, sucrose, dextrose, lactose, monacitin, triethyl phosphate, glycerol; monoethers of glycerol such as glycerol a - methyl ether; a - and b - gluco heptonic acid and/or their lactones and lower alkyl and glycol esters, glucono d -lactone, n -valerolactone; a -amino acids, e.g. glycine, ethyl glycinate; amines such as mono- and tri-ethanolamines; glycols such as propylene glycol, triethylene glycol, 2-ethyl-1,3 hexane diol, 1,3-butylene glycol; glycosides such as a -methyl glucoside, aceto-propanol; amides such as acetamide and propionamide. The capsule wall material may also contain (a) electrolytes, e.g. benzene sulphonic acid, toluene sulphonic acid and citric acid; (b) colouring materials such as edible of animal or vegetable origin, e.g. carmine, cudbear and caramel or synthetic dyes, e.g. amaranth, brilliant blue F.C.F., losin, erythrosine, guinea green certified, orange I, porceau 3R, sunset yellow F.C.F. and tartrazine; (c) substances rendering the capsule opaque, e.g. charcoal and titanium dioxide; (d) gums, e.g. acacia; (e) wetting agents, e.g. sodium dioctyl sulphosuccinate; (f) non-thermo-gelling cellulose derivatives, e.g. water soluble hydroxyethyl cellulose; (g) carbowax-a polyethylene glycol. The capsules are formed by dipping highly polished, stainless steel pins, maintained at say 65 DEG C, into a bubble-free aqueous solution of methyl cellulose of suitable viscosity preferably maintained at 18 DEG C (see Group IVa). The Specification as open to inspection under Sect. 91 comprises capsules having as an essential ingredient any water-soluble thermo-gelling etherified cellulose derivative, e.g. ethyl substituted ethers and methylated cellulose ethers of glycollic acid. This subject-matter does not appear in the Specification as accepted.
GB30847A 1946-04-13 1947-01-03 Medicinal capsules and process of manufacture Expired GB643853A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US643853X true 1946-04-13 1946-04-13

Publications (1)

Publication Number Publication Date
GB643853A true true GB643853A (en) 1950-09-27

Family

ID=22055582

Family Applications (1)

Application Number Title Priority Date Filing Date
GB30847A Expired GB643853A (en) 1946-04-13 1947-01-03 Medicinal capsules and process of manufacture

Country Status (1)

Country Link
GB (1) GB643853A (en)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1617432B1 (en) * 1965-09-07 1972-05-31 Dow Chemical Co A process for preparing medical capsules from a L|sung a cellulose ether having a low viscosity
EP0180287A2 (en) * 1984-10-23 1986-05-07 Shin-Etsu Chemical Co., Ltd. A cellulose ether composition and a hard medicinal capsule prepared therefrom
FR2757173A1 (en) * 1996-12-17 1998-06-19 Warner Lambert Co polymer compositions of non-animal origin for the formation of films
EP1093845A2 (en) * 1999-10-20 2001-04-25 Henkel Kommanditgesellschaft auf Aktien Microcapsules
WO2002016020A1 (en) * 2000-08-22 2002-02-28 Henkel Kommanditgesellschaft Auf Aktien Microcapsules
EP1547583A2 (en) * 2003-12-25 2005-06-29 Shin-Etsu Chemical Co., Ltd. Capsule comprising low-substituted cellulose ether
CN100420487C (en) 2007-04-24 2008-09-24 辽宁大生药业有限公司 Novel soft capsule peel composition
WO2009006378A1 (en) * 2007-07-05 2009-01-08 Dow Global Technologies Inc. Dissolvable film with detection functionality
US8547524B2 (en) 2006-03-21 2013-10-01 Lau Consulting, Inc. Active mask variable data integral imaging system and method
WO2013164122A1 (en) * 2012-05-02 2013-11-07 Capsugel France SAS Aqueous dispersions of controlled release polymers and shells and capsules thereof

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1617432B1 (en) * 1965-09-07 1972-05-31 Dow Chemical Co A process for preparing medical capsules from a L|sung a cellulose ether having a low viscosity
EP0180287A2 (en) * 1984-10-23 1986-05-07 Shin-Etsu Chemical Co., Ltd. A cellulose ether composition and a hard medicinal capsule prepared therefrom
EP0180287A3 (en) * 1984-10-23 1987-04-29 Shin-Etsu Chemical Co., Ltd. A cellulose ether composition and a hard medicinal capsule prepared therefrom
FR2757173A1 (en) * 1996-12-17 1998-06-19 Warner Lambert Co polymer compositions of non-animal origin for the formation of films
WO1998027151A1 (en) * 1996-12-17 1998-06-25 Warner-Lambert Company Polymer film compositions for capsules
EP1057862A2 (en) * 1996-12-17 2000-12-06 Warner-Lambert Company Polymer film compositions for capsules
EP1057862A3 (en) * 1996-12-17 2001-02-07 Warner-Lambert Company Polymer film compositions for capsules
EP1093845A2 (en) * 1999-10-20 2001-04-25 Henkel Kommanditgesellschaft auf Aktien Microcapsules
EP1093845A3 (en) * 1999-10-20 2001-05-30 Henkel Kommanditgesellschaft auf Aktien Microcapsules
WO2002016020A1 (en) * 2000-08-22 2002-02-28 Henkel Kommanditgesellschaft Auf Aktien Microcapsules
EP1547583A2 (en) * 2003-12-25 2005-06-29 Shin-Etsu Chemical Co., Ltd. Capsule comprising low-substituted cellulose ether
EP1547583A3 (en) * 2003-12-25 2005-11-16 Shin-Etsu Chemical Co., Ltd. Capsule comprising low-substituted cellulose ether
US8784883B2 (en) 2003-12-25 2014-07-22 Shin-Etsu Chemical Co., Ltd. Capsule comprising low-substituted cellulose ether and method for preparing the same
US8029821B2 (en) 2003-12-25 2011-10-04 Shin-Etsu Chemical Co. Ltd. Capsule comprising low-substituted cellulose ether and method for preparing the same
US8547524B2 (en) 2006-03-21 2013-10-01 Lau Consulting, Inc. Active mask variable data integral imaging system and method
CN100420487C (en) 2007-04-24 2008-09-24 辽宁大生药业有限公司 Novel soft capsule peel composition
WO2009006378A1 (en) * 2007-07-05 2009-01-08 Dow Global Technologies Inc. Dissolvable film with detection functionality
JP2010532421A (en) * 2007-07-05 2010-10-07 ダウ グローバル テクノロジーズ インコーポレイティド Soluble film having a detection function
WO2013164122A1 (en) * 2012-05-02 2013-11-07 Capsugel France SAS Aqueous dispersions of controlled release polymers and shells and capsules thereof

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