CN100569760C - 具有β2肾上腺素能受体激动剂和毒蕈碱性受体拮抗剂活性的化合物 - Google Patents

具有β2肾上腺素能受体激动剂和毒蕈碱性受体拮抗剂活性的化合物 Download PDF

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Publication number
CN100569760C
CN100569760C CNB2004800342018A CN200480034201A CN100569760C CN 100569760 C CN100569760 C CN 100569760C CN B2004800342018 A CNB2004800342018 A CN B2004800342018A CN 200480034201 A CN200480034201 A CN 200480034201A CN 100569760 C CN100569760 C CN 100569760C
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CN
China
Prior art keywords
subunit
benzene
nhc
group
hexamethylene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CNB2004800342018A
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English (en)
Chinese (zh)
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CN1882556A (zh
Inventor
M·马梅恩
S·邓纳姆
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Innoviva Inc
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Shiwan Pharmaceutical
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Publication of CN1882556A publication Critical patent/CN1882556A/zh
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Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Document Processing Apparatus (AREA)
  • Hydrogenated Pyridines (AREA)
CNB2004800342018A 2003-11-21 2004-11-19 具有β2肾上腺素能受体激动剂和毒蕈碱性受体拮抗剂活性的化合物 Expired - Fee Related CN100569760C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52423403P 2003-11-21 2003-11-21
US60/524,234 2003-11-21

Publications (2)

Publication Number Publication Date
CN1882556A CN1882556A (zh) 2006-12-20
CN100569760C true CN100569760C (zh) 2009-12-16

Family

ID=34632881

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB2004800342018A Expired - Fee Related CN100569760C (zh) 2003-11-21 2004-11-19 具有β2肾上腺素能受体激动剂和毒蕈碱性受体拮抗剂活性的化合物

Country Status (9)

Country Link
US (4) US7345060B2 (https=)
EP (1) EP1685118B1 (https=)
JP (2) JP4851937B2 (https=)
CN (1) CN100569760C (https=)
AT (1) ATE435855T1 (https=)
CA (1) CA2543858C (https=)
DE (1) DE602004021959D1 (https=)
ES (1) ES2329586T3 (https=)
WO (1) WO2005051946A2 (https=)

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Publication number Publication date
US7345060B2 (en) 2008-03-18
ES2329586T3 (es) 2009-11-27
CA2543858A1 (en) 2005-06-09
EP1685118A2 (en) 2006-08-02
ATE435855T1 (de) 2009-07-15
CN1882556A (zh) 2006-12-20
WO2005051946A3 (en) 2005-07-14
US20080096911A1 (en) 2008-04-24
JP2007514662A (ja) 2007-06-07
US8247564B2 (en) 2012-08-21
US20050113417A1 (en) 2005-05-26
CA2543858C (en) 2014-04-15
US20080097105A1 (en) 2008-04-24
JP4851937B2 (ja) 2012-01-11
DE602004021959D1 (de) 2009-08-20
EP1685118B1 (en) 2009-07-08
US20110034694A1 (en) 2011-02-10
JP2011190271A (ja) 2011-09-29
WO2005051946A2 (en) 2005-06-09
US7838535B2 (en) 2010-11-23
US7842704B2 (en) 2010-11-30

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