PE20050327A1 - Derivados de 8-azoniabiciclo[3.2.1]octano como antagonistas de los receptores muscarinicos de la acetilcolina - Google Patents

Derivados de 8-azoniabiciclo[3.2.1]octano como antagonistas de los receptores muscarinicos de la acetilcolina

Info

Publication number
PE20050327A1
PE20050327A1 PE2004000673A PE2004000673A PE20050327A1 PE 20050327 A1 PE20050327 A1 PE 20050327A1 PE 2004000673 A PE2004000673 A PE 2004000673A PE 2004000673 A PE2004000673 A PE 2004000673A PE 20050327 A1 PE20050327 A1 PE 20050327A1
Authority
PE
Peru
Prior art keywords
octane
endo
dimethyl
azoniabiciclo
antagonists
Prior art date
Application number
PE2004000673A
Other languages
English (en)
Inventor
Kristen E Belmonte
Jakob Busch-Petersen
Michael R Palovich
Dramane I Laine
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of PE20050327A1 publication Critical patent/PE20050327A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

SE REFIERE A COMPUESTOS DERIVADOS OLEFINICOS DE 8-AZONIABICICLO[3.2.1]OCTANO DE LA FORMULA I, EN DONDE R2 Y R3 SON ALQUILO C1-C6 DE CADENA LINEAL O RAMIFICADA, CICLOALQUILO C5-C6, CICLOALQUIL-ALQUILO C6-C10, 2-TIENILO, ENTRE OTROS; X- ES UN ANION ASOCIADO CON LA CARGA POSITIVA DEL ATOMO DE N; DE MODO QUE EL COMPUESTO ESTA EN FORMA DE SAL CUATERNARIA. SON COMPUESTOS PREFERIDOS: BROMURO DE (3-ENDO)-3-(2,2-DI-2-TIENILETENIL)-8,8-DIMETIL-8-AZONIABICICLO[3.2.1]OCTANO; BROMURO DE (3-ENDO)-3-(2,2-DIFENILETENIL)-8,8-DIMETIL-8-AZONIABICICLO[3.2.1]OCTANO; 4-METILBENCENOSULFONATO DE (3-ENDO)-3-(2,2-DIFENILETENIL)-8,8-DIMETIL-8-AZONIABICICLO[3.2.1]OCTANO; ENTRE OTROS. TAMBIEN SE REFIERE A UN COMPUESTO FARMACEUTICO. ESTOS COMPUESTOS SON ANTAGONISTAS DEL RECEPTOR MUSCARINICO DE LA ACETILCOLINA Y SON UTILES PARA TRATAR ENFERMEDADES MEDIADAS POR ESTOS RECEPTORES COMO SON LA ENFERMEDAD PULMONAR OBSTRUCTIVA CRONICA, BRONQUITIS CRONICA, ASMA, OBSTRUCCION RESPIRATORIA CRONICA, FIBROSIS PULMONAR, ENFISEMA PULMONAR Y RINITIS ALERGICA
PE2004000673A 2003-07-17 2004-07-15 Derivados de 8-azoniabiciclo[3.2.1]octano como antagonistas de los receptores muscarinicos de la acetilcolina PE20050327A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US48798103P 2003-07-17 2003-07-17

Publications (1)

Publication Number Publication Date
PE20050327A1 true PE20050327A1 (es) 2005-06-08

Family

ID=34102735

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2004000673A PE20050327A1 (es) 2003-07-17 2004-07-15 Derivados de 8-azoniabiciclo[3.2.1]octano como antagonistas de los receptores muscarinicos de la acetilcolina

Country Status (21)

Country Link
US (1) US20060178395A1 (es)
EP (1) EP1648460A4 (es)
JP (1) JP2007523877A (es)
KR (1) KR20060063890A (es)
CN (1) CN1822838A (es)
AP (1) AP2006003478A0 (es)
AR (1) AR045913A1 (es)
AU (1) AU2004259232A1 (es)
BR (1) BRPI0412716A (es)
CA (1) CA2532375A1 (es)
EA (1) EA200600267A1 (es)
EC (1) ECSP056254A (es)
IL (1) IL172822A0 (es)
IS (1) IS8302A (es)
MA (1) MA27900A1 (es)
MX (1) MXPA06000662A (es)
NO (1) NO20060775L (es)
PE (1) PE20050327A1 (es)
TW (1) TW200523261A (es)
UY (1) UY28417A1 (es)
WO (1) WO2005009439A1 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR045914A1 (es) * 2003-07-17 2005-11-16 Glaxo Group Ltd Compuesto alcoholico terciario del 8-azoniabiciclo [3.2.1] octano, composicion farmaceutica que lo comprende y su uso para preparar esta ultima
EA013435B1 (ru) 2003-10-14 2010-04-30 Глэксо Груп Лимитед Антагонисты мускариновых ацетилхолиновых рецепторов
CN1897947A (zh) * 2003-10-17 2007-01-17 葛兰素集团有限公司 蕈毒碱乙酰胆碱受体拮抗剂
PE20050489A1 (es) * 2003-11-04 2005-09-02 Glaxo Group Ltd Antagonistas de receptores de acetilcolina muscarinicos
US20090253908A1 (en) * 2004-03-11 2009-10-08 Glaxo Group Limited Novel m3 muscarinic acetylchoine receptor antagonists
EP1725564A4 (en) * 2004-03-17 2007-09-12 Glaxo Group Ltd ANTAGONISTS OF THE M3 MUSCARIN ACETYL CHOLIN RECEPTOR
WO2005094251A2 (en) * 2004-03-17 2005-10-13 Glaxo Group Limited M3muscarinic acetylcholine receptor antagonists
PE20060259A1 (es) 2004-04-27 2006-03-25 Glaxo Group Ltd Compuestos de quinuclidina como antagonistas del receptor de acetilcolina muscarinico
JP2007537261A (ja) * 2004-05-13 2007-12-20 グラクソ　グループ　リミテッド ムスカリン性アセチルコリン受容体アンタゴニスト
US7932247B2 (en) * 2004-11-15 2011-04-26 Glaxo Group Limited M3 muscarinic acetylcholine receptor antagonists
TWI268704B (en) * 2005-06-28 2006-12-11 Realtek Semiconductor Corp Apparatus and method for detecting vertical blanking interval
US20080234315A1 (en) * 2005-08-02 2008-09-25 Jakob Busch-Petersen M3 Muscarinic Acetylcholine Receptor Antagonists
CL2009000250A1 (es) 2008-02-06 2009-09-11 Glaxo Group Ltd Compuestos derivados de pirazolo[3,4-b]piridina carboxamida; composicion farmaceutica que los comprende; y su uso en el tratamiento del asma, epoc y rinitis.
UY31635A1 (es) 2008-02-06 2009-08-31 Farmacóforos duales-antagonistas muscarínicos de pde4
UY31636A1 (es) 2008-02-06 2009-08-03 Farmacoforos duales-antagonistas muscarinicos de pde4
WO2010094643A1 (en) 2009-02-17 2010-08-26 Glaxo Group Limited Quinoline derivatives and their uses for rhinitis and urticaria
EP2627317A4 (en) * 2010-10-15 2014-08-20 Glaxo Group Ltd MEDICINAL FORMULATIONS FROM AGGREGATED NANOPARTICLES AND THEIR PREPARATION AND USE
WO2013153146A1 (en) 2012-04-13 2013-10-17 Glaxosmithkline Intellectual Property Development Limited Aggregate particles
WO2021191875A1 (en) 2020-03-26 2021-09-30 Glaxosmithkline Intellectual Property Development Limited Cathepsin inhibitors for preventing or treating viral infections

Family Cites Families (11)

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Publication number Priority date Publication date Assignee Title
US2800482A (en) * 1955-07-01 1957-07-23 Smith Kline French Lab Olefinic derivatives of 8-alkylnortropanes and the acid and quaternary ammonium salts thereof
US2800478A (en) * 1955-07-01 1957-07-23 Smith Kline French Lab 3-substituted-8-alkylnortropanes and the acid and quaternary ammonium salts thereof
US2800481A (en) * 1955-07-01 1957-07-23 Smith Kline French Lab Tertiary alcohol derivatives of 8-alkylnortropanes and the acid and quaternary ammonium salts thereof
AU5790598A (en) * 1996-12-02 1998-06-29 Georgetown University Tropane derivatives and method for their synthesis
US6248752B1 (en) * 1998-02-27 2001-06-19 Charles Duane Smith Azabicyclooctane compositions and methods for enhancing chemotherapy
US6262066B1 (en) * 1998-07-27 2001-07-17 Schering Corporation High affinity ligands for nociceptin receptor ORL-1
AU774867B2 (en) * 1999-05-04 2004-07-08 Neurosearch A/S Heteroaryl diazabicycloalkanes, their preparation and use
ES2165768B1 (es) * 1999-07-14 2003-04-01 Almirall Prodesfarma Sa Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen.
AU2001271027B2 (en) * 2000-07-11 2005-07-07 Msd K.K. Ester derivatives
CA2462980A1 (en) * 2001-10-17 2003-04-24 Ucb, S.A. Quinuclidine derivatives, processes for preparing them and their uses as m2 and/or m3 muscarinic receptor inhibitors
DE602004021959D1 (de) * 2003-11-21 2009-08-20 Theravance Inc Verbindungen mit agonistischer wirkung am beta2-adrenergen rezeptor und am muscarinischen rezeptor

Also Published As

Publication number Publication date
AU2004259232A1 (en) 2005-02-03
ECSP056254A (es) 2006-04-19
CA2532375A1 (en) 2005-02-03
MXPA06000662A (es) 2006-03-30
KR20060063890A (ko) 2006-06-12
AR045913A1 (es) 2005-11-16
IL172822A0 (en) 2006-06-11
TW200523261A (en) 2005-07-16
US20060178395A1 (en) 2006-08-10
BRPI0412716A (pt) 2006-09-26
EP1648460A4 (en) 2009-04-01
IS8302A (is) 2006-02-14
AP2006003478A0 (en) 2006-02-28
JP2007523877A (ja) 2007-08-23
NO20060775L (no) 2006-04-11
EP1648460A1 (en) 2006-04-26
EA200600267A1 (ru) 2006-06-30
WO2005009439A1 (en) 2005-02-03
UY28417A1 (es) 2005-02-28
MA27900A1 (fr) 2006-05-02
CN1822838A (zh) 2006-08-23

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