PE20050711A1 - Compuestos 8-azoniabiciclo[3.2.1] octanos como antagonistas de los receptores muscarinicos de la acetilcolina - Google Patents

Compuestos 8-azoniabiciclo[3.2.1] octanos como antagonistas de los receptores muscarinicos de la acetilcolina

Info

Publication number
PE20050711A1
PE20050711A1 PE2004000675A PE2004000675A PE20050711A1 PE 20050711 A1 PE20050711 A1 PE 20050711A1 PE 2004000675 A PE2004000675 A PE 2004000675A PE 2004000675 A PE2004000675 A PE 2004000675A PE 20050711 A1 PE20050711 A1 PE 20050711A1
Authority
PE
Peru
Prior art keywords
alkyl
compounds
respiratory
octans
azoniabiciclo
Prior art date
Application number
PE2004000675A
Other languages
English (en)
Inventor
Jakob Busch-Petersen
Kristen E Belmonte
Dramane I Laine
Michael R Palovich
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of PE20050711A1 publication Critical patent/PE20050711A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Otolaryngology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE 8-AZONIABICICLO[3,2,1] OCTANOS SUSTITUIDOS EN LA POSICION 3 POR UNA CADENA ALQUILICA COMO ETILO, EL CUAL ESTA DISUSTITUIDO POR R2 Y R3; LA ORIENTACION PREFERIDA DE LA CADENA ALQUILICA UNIDA AL ANILLO DE TROPANO ES ENDO, R2 Y R3 SON INDEPENDIENTEMENTE, ALQUILO(C1-C6) LINEAL O RAMIFICADA, CICLOALQUILOS(C5-C6), CICLOALQUIL-ALQUILO(C6-C10), 2-TIENILO, 2-PIRIDILO Y FENILO OPCIONALMENTE SUSTITUIDO CON ALQUILO(C1-C4) O ALCOXI(C1-C4), EL ATOMO DE N CON CARGA POSITIVA ESTA ASOCIADO A UN ANION REPRESENTADO POR X- COMO CLORURO, BROMURO, YODURO, SULFATO, BENCENOSULFATO Y TOLUENOSULFATO. UN COMPUESTO PREFERIDO ES: BROMURO DE (3-ENDO)-2-(2,2-DIFENILETIL)-8,8-DIMETIL-8-AZONIABICICLO-[3.2.1] OCTANO. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE PUEDEN ADMINISTRARSE POR INHALACION POR VIA ORAL O NASAL. ESTOS COMPUESTOS SON INHIBIDORES DE LA UNION DE ACETILCOLINA A LOS RECEPTORES MUSCARINICOS, ESPECIALMENTE EL RECEPTOR mAChRM3, POR LO QUE SON UTILES EN EL TRATAMIENTO DE ENFERMEDADES RESPIRATORIAS COMO BRONQUITIS CRONICA, EPOC, OBSTRUCCION RESPIRATORIA, FIBROSIS PULMONAR Y RINITIS ALERGICA
PE2004000675A 2003-07-17 2004-07-15 Compuestos 8-azoniabiciclo[3.2.1] octanos como antagonistas de los receptores muscarinicos de la acetilcolina PE20050711A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US48806103P 2003-07-17 2003-07-17

Publications (1)

Publication Number Publication Date
PE20050711A1 true PE20050711A1 (es) 2005-09-10

Family

ID=34102742

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2004000675A PE20050711A1 (es) 2003-07-17 2004-07-15 Compuestos 8-azoniabiciclo[3.2.1] octanos como antagonistas de los receptores muscarinicos de la acetilcolina

Country Status (18)

Country Link
US (1) US20060160844A1 (es)
EP (1) EP1648462A4 (es)
JP (1) JP2007535477A (es)
KR (1) KR20060054317A (es)
CN (1) CN1822840A (es)
AR (1) AR048573A1 (es)
AU (1) AU2004259239A1 (es)
BR (1) BRPI0412679A (es)
CA (1) CA2532379A1 (es)
IL (1) IL172911A0 (es)
IS (1) IS8297A (es)
MA (1) MA27973A1 (es)
MX (1) MXPA06000664A (es)
NO (1) NO20060776L (es)
PE (1) PE20050711A1 (es)
RU (1) RU2006104854A (es)
TW (1) TW200519109A (es)
WO (1) WO2005009440A1 (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200519108A (en) * 2003-07-17 2005-06-16 Glaxo Group Ltd Muscarinic acetylcholine receptor antagonists
EA013689B1 (ru) 2003-10-14 2010-06-30 Глэксо Груп Лимитед Антагонисты мускариновых ацетилхолиновых рецепторов
MXPA06004242A (es) * 2003-10-17 2006-06-28 Glaxo Group Ltd Antagonistas del receptor muscarinico de la acetilcolina.
PE20050489A1 (es) * 2003-11-04 2005-09-02 Glaxo Group Ltd Antagonistas de receptores de acetilcolina muscarinicos
JP2007528420A (ja) * 2004-03-11 2007-10-11 グラクソ　グループ　リミテッド 新規ｍ３ムスカリン性アセチルコリン受容体アンタゴニスト
US20070185148A1 (en) * 2004-03-17 2007-08-09 Glaxo Group Limited M3 muscarinic acetylchoine receptor antagonists
EP1725564A4 (en) * 2004-03-17 2007-09-12 Glaxo Group Ltd ANTAGONISTS OF THE M3 MUSCARIN ACETYL CHOLIN RECEPTOR
UY28871A1 (es) 2004-04-27 2005-11-30 Glaxo Group Ltd Antagonistas del receptor de acetilcolina muscarinico
US7598267B2 (en) * 2004-05-13 2009-10-06 Glaxo Group Limited Muscarinic acetylcholine receptor antagonists
EP1957075A4 (en) * 2004-11-15 2009-11-18 Glaxo Group Ltd NOVEL ANTAGONISTS OF ACETYLCHOLINE M3 TYPE MUSCARINIC RECEPTORS
WO2006135715A1 (en) * 2005-06-10 2006-12-21 Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Benztropinamine analogs as dopamine uptake inhibitors
US20080275079A1 (en) * 2005-08-02 2008-11-06 Glaxo Group Limited M3 Muscarinic Acetylcholine Receptor Antagonists
US7767691B2 (en) 2005-08-18 2010-08-03 Glaxo Group Limited Muscarinic acetylcholine receptor antagonists containing an azoniabiocyclo[2.2.1] heptane ring system
EP1919476A2 (en) 2005-08-24 2008-05-14 Government of the United States of America, Represented by the Secretary, Department of Health and Human Services Benztropine compounds and uses thereof as dopamine uptake inhibitors
TW200946525A (en) 2008-02-06 2009-11-16 Glaxo Group Ltd Dual pharmacophores-PDE4-muscarinic antagonistics
TW201000476A (en) 2008-02-06 2010-01-01 Glaxo Group Ltd Dual pharmacophores-PDE4-muscarinic antagonistics
CL2009000248A1 (es) 2008-02-06 2009-09-11 Glaxo Group Ltd Compuestos derivados de pirazolo [3,4-b] piridin-5-il, inhibidores de la fosfodiesterasa de tipo iv (pde4) y antagonista de receptores muscarinicos de acetilcolina (machr); composicion farmaceutica que los comprende; y su uso en la preparacion de medicamentos utiles en el tratamiento de enferemedades respiratorias y alergicas
WO2010094643A1 (en) 2009-02-17 2010-08-26 Glaxo Group Limited Quinoline derivatives and their uses for rhinitis and urticaria

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2800482A (en) * 1955-07-01 1957-07-23 Smith Kline French Lab Olefinic derivatives of 8-alkylnortropanes and the acid and quaternary ammonium salts thereof
US2800478A (en) * 1955-07-01 1957-07-23 Smith Kline French Lab 3-substituted-8-alkylnortropanes and the acid and quaternary ammonium salts thereof
ES2165768B1 (es) * 1999-07-14 2003-04-01 Almirall Prodesfarma Sa Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen.
CA2415468A1 (en) * 2000-07-11 2003-01-10 Yoshio Ogino Ester derivatives
US6608055B2 (en) * 2001-06-22 2003-08-19 Boehringer Ingelheim Pharma Kg Crystalline anticholinergic, processes for preparing it and its use for preparing a pharmaceutical composition
EP1438309A1 (en) * 2001-10-17 2004-07-21 Ucb, S.A. Quinuclidine derivatives, processes for preparing them and their uses as m2 and/or m3 muscarinic receptor inhibitors
ATE435855T1 (de) * 2003-11-21 2009-07-15 Theravance Inc Verbindungen mit agonistischer wirkung am beta2- adrenergen rezeptor und am muscarinischen rezeptor

Also Published As

Publication number Publication date
IS8297A (is) 2006-02-13
TW200519109A (en) 2005-06-16
EP1648462A4 (en) 2009-04-08
IL172911A0 (en) 2006-06-11
NO20060776L (no) 2006-04-11
WO2005009440A1 (en) 2005-02-03
AR048573A1 (es) 2006-05-10
MXPA06000664A (es) 2006-03-30
CN1822840A (zh) 2006-08-23
BRPI0412679A (pt) 2006-10-03
KR20060054317A (ko) 2006-05-22
CA2532379A1 (en) 2005-02-03
EP1648462A1 (en) 2006-04-26
JP2007535477A (ja) 2007-12-06
RU2006104854A (ru) 2006-06-27
US20060160844A1 (en) 2006-07-20
AU2004259239A1 (en) 2005-02-03
MA27973A1 (fr) 2006-07-03

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