CN1004002B - 制备7-卤-7-去氧林可霉素及其类似化合物的改进方法 - Google Patents

制备7-卤-7-去氧林可霉素及其类似化合物的改进方法 Download PDF

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Publication number
CN1004002B
CN1004002B CN85101921.8A CN85101921A CN1004002B CN 1004002 B CN1004002 B CN 1004002B CN 85101921 A CN85101921 A CN 85101921A CN 1004002 B CN1004002 B CN 1004002B
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CN
China
Prior art keywords
lincomycin
chloride
compound
chloromethylene
halo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CN85101921.8A
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English (en)
Chinese (zh)
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CN85101921A (zh
Inventor
道格拉斯·阿伦·利文斯顿
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Priority to CN85101921.8A priority Critical patent/CN1004002B/zh
Publication of CN85101921A publication Critical patent/CN85101921A/zh
Publication of CN1004002B publication Critical patent/CN1004002B/zh
Expired legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/14—Acyclic radicals, not substituted by cyclic structures attached to a sulfur, selenium or tellurium atom of a saccharide radical
    • C07H15/16—Lincomycin; Derivatives thereof

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Indole Compounds (AREA)
CN85101921.8A 1984-11-29 1985-04-01 制备7-卤-7-去氧林可霉素及其类似化合物的改进方法 Expired CN1004002B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN85101921.8A CN1004002B (zh) 1984-11-29 1985-04-01 制备7-卤-7-去氧林可霉素及其类似化合物的改进方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67615784A 1984-11-29 1984-11-29
CN85101921.8A CN1004002B (zh) 1984-11-29 1985-04-01 制备7-卤-7-去氧林可霉素及其类似化合物的改进方法

Publications (2)

Publication Number Publication Date
CN85101921A CN85101921A (zh) 1987-01-10
CN1004002B true CN1004002B (zh) 1989-04-26

Family

ID=24713464

Family Applications (2)

Application Number Title Priority Date Filing Date
CN85101921.8A Expired CN1004002B (zh) 1984-11-29 1985-04-01 制备7-卤-7-去氧林可霉素及其类似化合物的改进方法
CN85108244A Expired CN1016694B (zh) 1984-11-29 1985-11-14 7-卤-7-脱氧林肯霉素的合成

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN85108244A Expired CN1016694B (zh) 1984-11-29 1985-11-14 7-卤-7-脱氧林肯霉素的合成

Country Status (19)

Country Link
US (1) US4710565A (cg-RX-API-DMAC7.html)
EP (1) EP0183505B1 (cg-RX-API-DMAC7.html)
JP (1) JPH0649714B2 (cg-RX-API-DMAC7.html)
KR (1) KR930003492B1 (cg-RX-API-DMAC7.html)
CN (2) CN1004002B (cg-RX-API-DMAC7.html)
AT (1) ATE50265T1 (cg-RX-API-DMAC7.html)
AU (1) AU574232B2 (cg-RX-API-DMAC7.html)
CA (1) CA1238319A (cg-RX-API-DMAC7.html)
DE (1) DE3575930D1 (cg-RX-API-DMAC7.html)
DK (1) DK165010C (cg-RX-API-DMAC7.html)
ES (1) ES8605817A1 (cg-RX-API-DMAC7.html)
FI (1) FI78708C (cg-RX-API-DMAC7.html)
GR (1) GR852861B (cg-RX-API-DMAC7.html)
HU (1) HU199497B (cg-RX-API-DMAC7.html)
IL (1) IL76778A (cg-RX-API-DMAC7.html)
MX (1) MX162251A (cg-RX-API-DMAC7.html)
PT (1) PT81496B (cg-RX-API-DMAC7.html)
SU (1) SU1405705A3 (cg-RX-API-DMAC7.html)
ZA (1) ZA858117B (cg-RX-API-DMAC7.html)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4568741A (en) * 1984-05-15 1986-02-04 The Upjohn Company Synthesis of 7-halo-7-deoxylincomycins
JP2531877Y2 (ja) * 1988-12-15 1997-04-09 日東工器株式会社 電磁式ダイアフラムポンプ
JP2531876Y2 (ja) * 1988-12-15 1997-04-09 日東工器株式会社 電磁式ダイアフラムポンプ用マグネットホルダ
JP2544782Y2 (ja) * 1988-12-27 1997-08-20 日東工器株式会社 電磁式ダイアフラムポンプ用マグネットホルダ
US6544555B2 (en) 2000-02-24 2003-04-08 Advancis Pharmaceutical Corp. Antibiotic product, use and formulation thereof
US6565882B2 (en) 2000-02-24 2003-05-20 Advancis Pharmaceutical Corp Antibiotic composition with inhibitor
US20020068078A1 (en) 2000-10-13 2002-06-06 Rudnic Edward M. Antifungal product, use and formulation thereof
US6541014B2 (en) 2000-10-13 2003-04-01 Advancis Pharmaceutical Corp. Antiviral product, use and formulation thereof
EP1421093B1 (en) * 2001-08-28 2005-06-29 Pharmacia Corporation Crystaline clindamycin free base
CA2493799A1 (en) * 2002-08-15 2004-02-26 Vicuron Pharmaceuticals, Inc. Lincomycin derivatives possessing antibacterial activity
US7199105B2 (en) * 2002-08-15 2007-04-03 Vicuron Pharmaceuticals, Inc. Lincomycin derivatives possessing antibacterial activity
ES2637956T3 (es) 2003-01-24 2017-10-18 Stiefel Research Australia Pty Ltd Espuma farmacéutica
US7256177B2 (en) 2003-06-17 2007-08-14 Vicuron Pharmaceuticals, Inc. Lincomycin derivatives possessing antibacterial activity
US7199106B2 (en) 2003-06-17 2007-04-03 Vicuron Pharmaceuticals, Inc. Lincomycin derivatives possessing antimicrobial activity
EP1648418A4 (en) 2003-07-21 2011-11-16 Middlebrook Pharmaceuticals Inc ANTIBIOTIC PRODUCT, ITS USE AND FORMULATION
AU2004258953B2 (en) 2003-07-21 2011-02-10 Shionogi, Inc. Antibiotic product, use and formulation thereof
JP2006528189A (ja) 2003-07-21 2006-12-14 アドバンシス ファーマスーティカル コーポレイション 抗生物質産物、その使用法および製剤
EP1653925A1 (en) 2003-08-11 2006-05-10 Advancis Pharmaceutical Corporation Robust pellet
EP1653924A4 (en) 2003-08-12 2009-09-09 Middlebrook Pharmaceuticals In ANTIBIOTICS, USE AND FORMULATION ASSOCIATED
US8246996B2 (en) 2003-08-29 2012-08-21 Shionogi Inc. Antibiotic product, use and formulation thereof
CA2538064C (en) 2003-09-15 2013-12-17 Advancis Pharmaceutical Corporation Antibiotic product, use and formulation thereof
US7361743B2 (en) * 2004-02-11 2008-04-22 Pfizer Inc Lincomycin derivatives possessing antibacterial activity
CA2572292A1 (en) 2004-07-02 2006-02-09 Advancis Pharmaceutical Corporation Tablet for pulsed delivery
US8778924B2 (en) 2006-12-04 2014-07-15 Shionogi Inc. Modified release amoxicillin products
US8357394B2 (en) 2005-12-08 2013-01-22 Shionogi Inc. Compositions and methods for improved efficacy of penicillin-type antibiotics
KR20090007556A (ko) * 2006-02-28 2009-01-19 브이.비. 메디케어 프리베이트 엘티디. 염소화 시약의 제조 공정 및 염소화 당의 제조에 있어 그의용도
ES2582654T3 (es) 2006-03-31 2016-09-14 Stiefel Research Australia Pty Ltd Gel en suspensión espumable
US8299052B2 (en) 2006-05-05 2012-10-30 Shionogi Inc. Pharmaceutical compositions and methods for improved bacterial eradication
CN101205245B (zh) * 2007-12-06 2011-04-06 河南天方药业股份有限公司 盐酸克林霉素的制备方法
CN102675146A (zh) * 2012-05-22 2012-09-19 山东凯盛新材料股份有限公司 新型固体氯化剂（氯亚甲基）二甲基氯化铵的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3496163A (en) * 1965-02-08 1970-02-17 Upjohn Co 7-halo-7-deoxylincomycins and process for preparing the same
US3435025A (en) * 1966-03-18 1969-03-25 Upjohn Co 7-deoxylincomycin and analogs and isomers thereof and process for making the same
US3580904A (en) * 1969-04-03 1971-05-25 Upjohn Co 7-halo-7-deoxy-lincomycin derivatives
US3574186A (en) * 1969-10-08 1971-04-06 Upjohn Co Process for making 7-chloro-7-deoxylincomycin and related compounds and novel intermediates produced therein
US4568741A (en) * 1984-05-15 1986-02-04 The Upjohn Company Synthesis of 7-halo-7-deoxylincomycins

Also Published As

Publication number Publication date
KR860004077A (ko) 1986-06-16
CN1016694B (zh) 1992-05-20
DE3575930D1 (de) 1990-03-15
PT81496A (en) 1985-12-01
EP0183505B1 (en) 1990-02-07
MX162251A (es) 1991-04-17
DK542785A (da) 1986-05-30
CA1238319A (en) 1988-06-21
IL76778A0 (en) 1986-02-28
CN85101921A (zh) 1987-01-10
FI854711A0 (fi) 1985-11-28
AU574232B2 (en) 1988-06-30
DK165010B (da) 1992-09-28
ES548152A0 (es) 1986-04-01
FI78708C (fi) 1989-09-11
AU4883785A (en) 1986-06-05
JPS61137892A (ja) 1986-06-25
SU1405705A3 (ru) 1988-06-23
PT81496B (pt) 1987-11-11
CN85108244A (zh) 1986-08-20
FI78708B (fi) 1989-05-31
DK165010C (da) 1993-02-22
DK542785D0 (da) 1985-11-22
ATE50265T1 (de) 1990-02-15
FI854711L (fi) 1986-05-30
ES8605817A1 (es) 1986-04-01
US4710565A (en) 1987-12-01
IL76778A (en) 1991-09-16
HU199497B (en) 1990-02-28
EP0183505A3 (en) 1987-06-24
ZA858117B (en) 1986-06-25
JPH0649714B2 (ja) 1994-06-29
KR930003492B1 (ko) 1993-05-01
HUT40806A (en) 1987-02-27
EP0183505A2 (en) 1986-06-04
GR852861B (cg-RX-API-DMAC7.html) 1986-03-28

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Free format text: CORRECT: PATENTEE; FROM: UPJOHN COMPANY TO: FARMACIA AND THE UPJOHN CO.

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Patentee after: Pharmacia & Upjohn Co.

Patentee before: The Upjohn Co.

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