CN100378140C - 杂质量降低的嵌段共聚物、聚合载体、呈聚合形式的药物制剂及其制备方法 - Google Patents
杂质量降低的嵌段共聚物、聚合载体、呈聚合形式的药物制剂及其制备方法 Download PDFInfo
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- CN100378140C CN100378140C CNB028122844A CN02812284A CN100378140C CN 100378140 C CN100378140 C CN 100378140C CN B028122844 A CNB028122844 A CN B028122844A CN 02812284 A CN02812284 A CN 02812284A CN 100378140 C CN100378140 C CN 100378140C
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- 229960001221 pirarubicin Drugs 0.000 description 1
- 239000002798 polar solvent Substances 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- 125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 description 1
- 238000000197 pyrolysis Methods 0.000 description 1
- 238000004445 quantitative analysis Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 230000008707 rearrangement Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- DCKVNWZUADLDEH-UHFFFAOYSA-N sec-butyl acetate Chemical compound CCC(C)OC(C)=O DCKVNWZUADLDEH-UHFFFAOYSA-N 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 159000000000 sodium salts Chemical group 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000010189 synthetic method Methods 0.000 description 1
- 238000011191 terminal modification Methods 0.000 description 1
- 125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 description 1
- 125000005270 trialkylamine group Chemical group 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
- C08G69/40—Polyamides containing oxygen in the form of ether groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Polymers & Plastics (AREA)
- Medicinal Preparation (AREA)
- Polyamides (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Polyethers (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Materials For Medical Uses (AREA)
Abstract
Description
Claims (9)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP187175/2001 | 2001-06-20 | ||
JP2001187175 | 2001-06-20 | ||
JP2001187176 | 2001-06-20 | ||
JP187176/2001 | 2001-06-20 | ||
PCT/JP2002/006112 WO2003000771A1 (fr) | 2001-06-20 | 2002-06-19 | Copolymere bloc a taux d'impuretes reduit, support polymere, preparations pharmaceutiques sous forme polymere et procede de preparation associe |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1518573A CN1518573A (zh) | 2004-08-04 |
CN100378140C true CN100378140C (zh) | 2008-04-02 |
Family
ID=26617300
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB028122844A Expired - Lifetime CN100378140C (zh) | 2001-06-20 | 2002-06-19 | 杂质量降低的嵌段共聚物、聚合载体、呈聚合形式的药物制剂及其制备方法 |
Country Status (13)
Country | Link |
---|---|
US (1) | US7138490B2 (zh) |
EP (1) | EP1408066B1 (zh) |
JP (1) | JP4462928B2 (zh) |
KR (1) | KR100924990B1 (zh) |
CN (1) | CN100378140C (zh) |
AT (1) | ATE462746T1 (zh) |
AU (1) | AU2002346296B2 (zh) |
CA (1) | CA2450448C (zh) |
DE (1) | DE60235812D1 (zh) |
ES (1) | ES2343679T3 (zh) |
PL (1) | PL222061B1 (zh) |
RU (1) | RU2282641C2 (zh) |
WO (1) | WO2003000771A1 (zh) |
Families Citing this family (45)
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ES2488841T3 (es) * | 2002-10-31 | 2014-08-29 | Nippon Kayaku Kabushiki Kaisha | Derivados de alto peso molecular de camptotecinas |
JP4535229B2 (ja) * | 2003-05-08 | 2010-09-01 | 国立大学法人 東京大学 | ポリエチレングリコール−ポリカチオンブロック共重合体 |
WO2004105799A1 (ja) * | 2003-05-29 | 2004-12-09 | Toudai Tlo, Ltd. | 安定化高分子ミセル |
CA2542049C (en) * | 2003-10-10 | 2012-07-17 | Japan Science And Technology Agency | Finely particulate composite containing carbon compound encapsulated therein |
EP1792927B1 (en) * | 2004-09-22 | 2013-03-06 | Nippon Kayaku Kabushiki Kaisha | Novel block copolymer, micelle preparation, and anticancer agent containing the same as active ingredient |
JPWO2007034795A1 (ja) * | 2005-09-20 | 2009-03-26 | 株式会社ジェノラックBl | γ−ポリグルタミン酸架橋物及びその製造方法 |
BRPI0616877A2 (pt) | 2005-10-05 | 2011-07-05 | Tokyo Cro Inc | copolìmero em bloco biocompatìvel, micela, particulado, compósito, composição farmacêutica, método para fabricar uma micela, particulado ou compósito, e, uso de um copolìmero em bloco biocompatìvel |
KR20080074207A (ko) * | 2005-12-05 | 2008-08-12 | 닛토덴코 가부시키가이샤 | 폴리글루타메이트-아미노산 콘쥬게이트 및 이의 제조 방법 |
WO2007111211A1 (ja) | 2006-03-28 | 2007-10-04 | Nippon Kayaku Kabushiki Kaisha | タキサン類の高分子結合体 |
JP5181347B2 (ja) | 2006-05-18 | 2013-04-10 | 日本化薬株式会社 | ポドフィロトキシン類の高分子結合体 |
JP5548364B2 (ja) * | 2006-10-03 | 2014-07-16 | 日本化薬株式会社 | レゾルシノール誘導体の高分子結合体 |
US8334364B2 (en) | 2006-11-06 | 2012-12-18 | Nipon Kayaku Kabushiki Kaisha | High-molecular weight derivative of nucleic acid antimetabolite |
WO2008056654A1 (en) | 2006-11-08 | 2008-05-15 | Nippon Kayaku Kabushiki Kaisha | Polymeric derivative of nucleic acid metabolic antagonist |
US20080181852A1 (en) * | 2007-01-29 | 2008-07-31 | Nitto Denko Corporation | Multi-functional Drug Carriers |
CN101674852A (zh) * | 2007-04-10 | 2010-03-17 | 日东电工株式会社 | 多功能聚谷氨酸盐药物载体 |
EP2155253A2 (en) * | 2007-05-09 | 2010-02-24 | Nitto Denko Corporation | Polyglutamate conjugates and polyglutamate-amino acid conjugates having a plurality of drugs |
US8197828B2 (en) * | 2007-05-09 | 2012-06-12 | Nitto Denko Corporation | Compositions that include a hydrophobic compound and a polyamino acid conjugate |
CN101730549B (zh) * | 2007-05-09 | 2015-12-09 | 日东电工株式会社 | 与铂类药物结合的聚合物 |
KR100941774B1 (ko) * | 2007-09-06 | 2010-02-11 | 성균관대학교산학협력단 | 인체안전성이 우수한 온도 및 피에치 민감성 블록공중합체및 이의 제조방법과 이를 이용한 약물전달체 |
USRE46190E1 (en) | 2007-09-28 | 2016-11-01 | Nippon Kayaku Kabushiki Kaisha | High-molecular weight conjugate of steroids |
JP5576291B2 (ja) * | 2007-12-31 | 2014-08-20 | サムヤン バイオファーマシューティカルズ コーポレイション | ポリ(α−ヒドロキシ酸)の疎水性高分子ブロックを含む高純度の両親媒性ブロック共重合体及びその製造方法 |
AU2009222230A1 (en) * | 2008-03-06 | 2009-09-11 | Nitto Denko Corporation | Polymer paclitaxel conjugates and methods for treating cancer |
KR101589582B1 (ko) | 2008-03-18 | 2016-01-28 | 니폰 가야꾸 가부시끼가이샤 | 생리활성물질의 고분자량 결합체 |
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US9149540B2 (en) | 2008-05-08 | 2015-10-06 | Nippon Kayaku Kabushiki Kaisha | Polymer conjugate of folic acid or folic acid derivative |
JP5037684B2 (ja) * | 2008-05-23 | 2012-10-03 | ナノキャリア株式会社 | ドセタキセル高分子誘導体、並びにその製造方法及びその用途 |
JP5544357B2 (ja) | 2009-05-15 | 2014-07-09 | 日本化薬株式会社 | 水酸基を有する生理活性物質の高分子結合体 |
WO2012067138A1 (ja) | 2010-11-17 | 2012-05-24 | 日本化薬株式会社 | 新規なシチジン系代謝拮抗剤の高分子誘導体 |
WO2013009885A2 (en) | 2011-07-11 | 2013-01-17 | Momenta Pharmaceuticals, Inc. | Evaluation of copolymer diethylamide |
US8575198B1 (en) | 2011-09-07 | 2013-11-05 | Momenta Pharmaceuticals, Inc. | In-process control for the manufacture of glatiramer acetate |
US9346923B2 (en) | 2011-09-11 | 2016-05-24 | Nippon Kayaku Kabushiki Kaisha | Method for manufacturing block copolymer |
US8691925B2 (en) | 2011-09-23 | 2014-04-08 | Az Electronic Materials (Luxembourg) S.A.R.L. | Compositions of neutral layer for directed self assembly block copolymers and processes thereof |
US8686109B2 (en) * | 2012-03-09 | 2014-04-01 | Az Electronic Materials (Luxembourg) S.A.R.L. | Methods and materials for removing metals in block copolymers |
US10457088B2 (en) | 2013-05-13 | 2019-10-29 | Ridgefield Acquisition | Template for self assembly and method of making a self assembled pattern |
US9093263B2 (en) | 2013-09-27 | 2015-07-28 | Az Electronic Materials (Luxembourg) S.A.R.L. | Underlayer composition for promoting self assembly and method of making and using |
KR20150066151A (ko) | 2013-12-06 | 2015-06-16 | 삼성전자주식회사 | 블록 공중합체의 정제 방법 및 블록 공중합체를 이용한 패턴 형성 방법 |
US9181449B2 (en) | 2013-12-16 | 2015-11-10 | Az Electronic Materials (Luxembourg) S.A.R.L. | Underlayer composition for promoting self assembly and method of making and using |
CN104109235B (zh) * | 2014-05-30 | 2017-07-18 | 厦门赛诺邦格生物科技股份有限公司 | 一种具有氮原子支化中心的单一官能化聚乙二醇、制备方法及其生物相关物质 |
KR101726728B1 (ko) | 2015-07-28 | 2017-04-14 | 주식회사 삼양바이오팜 | 고분자 담체 함유 약학 조성물의 유연물질 분석 방법 |
US10945997B2 (en) | 2016-01-08 | 2021-03-16 | Nippon Kayaku Kabushiki Kaisha | Polymer derivative of macrolide immunosuppressant |
US11518730B2 (en) | 2016-08-18 | 2022-12-06 | Merck Patent Gmbh | Polymer compositions for self-assembly applications |
SG10202108825RA (en) | 2016-12-21 | 2021-09-29 | Ridgefield Acquisition | Novel compositions and processes for self-assembly of block copolymers |
CN107313258A (zh) * | 2017-06-23 | 2017-11-03 | 安徽金钻智能科技有限公司 | 一种蚕丝织物精炼用低泡耐碱渗透剂 |
WO2023176809A1 (ja) * | 2022-03-17 | 2023-09-21 | 日油株式会社 | ポリエチレングリコール誘導体の製造方法 |
CN115894905B (zh) * | 2022-08-30 | 2023-08-08 | 山东华铂凯盛生物科技有限公司 | 一种高纯度窄分子量分布的甲氧基聚乙二醇-聚(l-谷氨酸钠)的制备方法和应用 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH06206832A (ja) * | 1992-10-27 | 1994-07-26 | Nippon Kayaku Co Ltd | 高分子担体 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2517760B2 (ja) | 1989-05-11 | 1996-07-24 | 新技術事業団 | 水溶性高分子化医薬製剤 |
JP3111099B2 (ja) * | 1991-10-31 | 2000-11-20 | 科学技術振興事業団 | 水溶性高分子化薬剤の製造法 |
JP3270592B2 (ja) * | 1992-10-26 | 2002-04-02 | 日本化薬株式会社 | ブロック共重合体−抗癌剤複合体医薬製剤 |
JP3682475B2 (ja) | 1993-08-31 | 2005-08-10 | 靖久 桜井 | 水溶性抗癌剤 |
WO1997012895A1 (fr) | 1995-09-29 | 1997-04-10 | Japan Science And Technology Corporation | Nouveaux derives de composes d'anthracycline, et preparations medicamenteuses les contenant |
-
2002
- 2002-06-19 EP EP02743647A patent/EP1408066B1/en not_active Expired - Lifetime
- 2002-06-19 RU RU2004101281/04A patent/RU2282641C2/ru active
- 2002-06-19 ES ES02743647T patent/ES2343679T3/es not_active Expired - Lifetime
- 2002-06-19 US US10/481,347 patent/US7138490B2/en not_active Expired - Lifetime
- 2002-06-19 CA CA2450448A patent/CA2450448C/en not_active Expired - Lifetime
- 2002-06-19 KR KR1020037016687A patent/KR100924990B1/ko active IP Right Grant
- 2002-06-19 AU AU2002346296A patent/AU2002346296B2/en not_active Expired
- 2002-06-19 PL PL366773A patent/PL222061B1/pl unknown
- 2002-06-19 CN CNB028122844A patent/CN100378140C/zh not_active Expired - Lifetime
- 2002-06-19 DE DE60235812T patent/DE60235812D1/de not_active Expired - Lifetime
- 2002-06-19 JP JP2003507171A patent/JP4462928B2/ja not_active Expired - Lifetime
- 2002-06-19 WO PCT/JP2002/006112 patent/WO2003000771A1/ja active Application Filing
- 2002-06-19 AT AT02743647T patent/ATE462746T1/de not_active IP Right Cessation
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH06206832A (ja) * | 1992-10-27 | 1994-07-26 | Nippon Kayaku Co Ltd | 高分子担体 |
Also Published As
Publication number | Publication date |
---|---|
CA2450448A1 (en) | 2003-01-03 |
EP1408066B1 (en) | 2010-03-31 |
AU2002346296B2 (en) | 2007-09-13 |
ES2343679T3 (es) | 2010-08-06 |
US7138490B2 (en) | 2006-11-21 |
WO2003000771A1 (fr) | 2003-01-03 |
EP1408066A4 (en) | 2004-09-29 |
RU2004101281A (ru) | 2005-06-27 |
PL366773A1 (en) | 2005-02-07 |
JP4462928B2 (ja) | 2010-05-12 |
JPWO2003000771A1 (ja) | 2004-10-07 |
ATE462746T1 (de) | 2010-04-15 |
US20040151690A1 (en) | 2004-08-05 |
EP1408066A1 (en) | 2004-04-14 |
PL222061B1 (pl) | 2016-06-30 |
RU2282641C2 (ru) | 2006-08-27 |
KR100924990B1 (ko) | 2009-11-04 |
CN1518573A (zh) | 2004-08-04 |
DE60235812D1 (de) | 2010-05-12 |
KR20040030693A (ko) | 2004-04-09 |
CA2450448C (en) | 2011-12-13 |
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Effective date of registration: 20060303 Address after: Tokyo, Japan Applicant after: Nippon Kayaku K. K. Co-applicant after: Sakurai, Yasuhisa Address before: Tokyo, Japan Applicant before: Nippon Kayaku K. K. Co-applicant before: Independent Administrative Corporation Japan Science & Tech Corp. Co-applicant before: Sakurai, Yasuhisa |
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