DE60235812D1 - Blockcopolymer mit verringertem verunreinigungsgehalt, polymerer träger, pharmazeutische zubereitungen in polymerer form und verfahren zur herstellung davon - Google Patents

Blockcopolymer mit verringertem verunreinigungsgehalt, polymerer träger, pharmazeutische zubereitungen in polymerer form und verfahren zur herstellung davon

Info

Publication number
DE60235812D1
DE60235812D1 DE60235812T DE60235812T DE60235812D1 DE 60235812 D1 DE60235812 D1 DE 60235812D1 DE 60235812 T DE60235812 T DE 60235812T DE 60235812 T DE60235812 T DE 60235812T DE 60235812 D1 DE60235812 D1 DE 60235812D1
Authority
DE
Germany
Prior art keywords
block copolymer
polymeric
production
pharmaceutical preparations
polymer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60235812T
Other languages
English (en)
Inventor
Takeshi Nakanishi
Kazuhisa Shimizu
Ryuji Uehara
Masanobu Suzuki
Megumi Machida
Tomoko Akutsu
Shigeto Fukushima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sakurai Masato Jp
Nippon Kayaku Co Ltd
Original Assignee
Nippon Kayaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Kayaku Co Ltd filed Critical Nippon Kayaku Co Ltd
Application granted granted Critical
Publication of DE60235812D1 publication Critical patent/DE60235812D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/40—Polyamides containing oxygen in the form of ether groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Polymers & Plastics (AREA)
  • Medicinal Preparation (AREA)
  • Polyamides (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Polyethers (AREA)
  • Materials For Medical Uses (AREA)
DE60235812T 2001-06-20 2002-06-19 Blockcopolymer mit verringertem verunreinigungsgehalt, polymerer träger, pharmazeutische zubereitungen in polymerer form und verfahren zur herstellung davon Expired - Lifetime DE60235812D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2001187175 2001-06-20
JP2001187176 2001-06-20
PCT/JP2002/006112 WO2003000771A1 (fr) 2001-06-20 2002-06-19 Copolymere bloc a taux d'impuretes reduit, support polymere, preparations pharmaceutiques sous forme polymere et procede de preparation associe

Publications (1)

Publication Number Publication Date
DE60235812D1 true DE60235812D1 (de) 2010-05-12

Family

ID=26617300

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60235812T Expired - Lifetime DE60235812D1 (de) 2001-06-20 2002-06-19 Blockcopolymer mit verringertem verunreinigungsgehalt, polymerer träger, pharmazeutische zubereitungen in polymerer form und verfahren zur herstellung davon

Country Status (13)

Country Link
US (1) US7138490B2 (de)
EP (1) EP1408066B1 (de)
JP (1) JP4462928B2 (de)
KR (1) KR100924990B1 (de)
CN (1) CN100378140C (de)
AT (1) ATE462746T1 (de)
AU (1) AU2002346296B2 (de)
CA (1) CA2450448C (de)
DE (1) DE60235812D1 (de)
ES (1) ES2343679T3 (de)
PL (1) PL222061B1 (de)
RU (1) RU2282641C2 (de)
WO (1) WO2003000771A1 (de)

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CN1309763C (zh) * 2002-10-31 2007-04-11 日本化药株式会社 喜树碱的高分子衍生物
JP4535229B2 (ja) * 2003-05-08 2010-09-01 国立大学法人 東京大学 ポリエチレングリコール−ポリカチオンブロック共重合体
WO2004105799A1 (ja) * 2003-05-29 2004-12-09 Toudai Tlo, Ltd. 安定化高分子ミセル
CA2542049C (en) * 2003-10-10 2012-07-17 Japan Science And Technology Agency Finely particulate composite containing carbon compound encapsulated therein
AU2005285953B2 (en) 2004-09-22 2011-01-20 Nippon Kayaku Kabushiki Kaisha Novel block copolymer, micelle preparation, and anticancer agent containing the same as active ingredient
US20090258079A1 (en) 2005-05-10 2009-10-15 Ryoichi Katakai Biocompatible Block Copolymer, Use Thereof and Manufacturing Method Thereof
WO2007034795A1 (ja) * 2005-09-20 2007-03-29 Genolac Bl Corporation γ－ポリグルタミン酸架橋物及びその製造方法
CA2631704A1 (en) 2005-12-05 2007-06-14 Nitto Denko Corporation Polyglutamate-amino acid conjugates and methods
KR20080106254A (ko) 2006-03-28 2008-12-04 니폰 가야꾸 가부시끼가이샤 탁산류의 고분자 결합체
WO2007135910A1 (ja) 2006-05-18 2007-11-29 Nippon Kayaku Kabushiki Kaisha ポドフィロトキシン類の高分子結合体
CA2664852A1 (en) * 2006-10-03 2008-04-10 Nippon Kayaku Kabushiki Kaisha High-molecular weight conjugate of resorcinol derivatives
US8334364B2 (en) 2006-11-06 2012-12-18 Nipon Kayaku Kabushiki Kaisha High-molecular weight derivative of nucleic acid antimetabolite
EP2090607B1 (de) 2006-11-08 2015-05-20 Nippon Kayaku Kabushiki Kaisha Polymerderivat eines nukleinsäuremetabolismus-antagonisten
US20080181852A1 (en) * 2007-01-29 2008-07-31 Nitto Denko Corporation Multi-functional Drug Carriers
WO2008124735A2 (en) * 2007-04-10 2008-10-16 Nitto Denko Corporation Multi-functional polyglutamate drug carriers
US20080279782A1 (en) * 2007-05-09 2008-11-13 Nitto Denko Corporation Polymers conjugated with platinum drugs
JP2010526917A (ja) * 2007-05-09 2010-08-05 日東電工株式会社 複数種の薬物を有するポリグルタミン酸塩複合体及びポリグルタミン酸塩−アミノ酸複合体
JP5341879B2 (ja) 2007-05-09 2013-11-13 日東電工株式会社 疎水性化合物及びポリアミノ酸複合体を含む組成物
KR100941774B1 (ko) * 2007-09-06 2010-02-11 성균관대학교산학협력단 인체안전성이 우수한 온도 및 피에치 민감성 블록공중합체및 이의 제조방법과 이를 이용한 약물전달체
WO2009041570A1 (ja) 2007-09-28 2009-04-02 Nippon Kayaku Kabushiki Kaisha ステロイド類の高分子結合体
EP2229417B1 (de) * 2007-12-31 2014-07-30 Samyang Biopharmaceuticals Corporation Verfahren zur herstellung eines hochreinen amphiphilen copolymer mit einem hydrophoben block aus alphahydroxysäure
CN102083468A (zh) * 2008-03-06 2011-06-01 日东电工株式会社 用于治疗癌症的聚合物紫杉醇结合物和方法
US8920788B2 (en) 2008-03-18 2014-12-30 Nippon Kayaku Kabushiki Kaisha High-molecular weight conjugate of physiologically active substances
WO2009129018A1 (en) † 2008-04-16 2009-10-22 Momenta Pharmaceuticals, Inc. Analysis of amino acid copolymer compositions
EP2284209B1 (de) 2008-05-08 2016-08-31 Nippon Kayaku Kabushiki Kaisha Polymerkonjugat aus folsäure oder einem folsäurederivat
EP2287230B1 (de) * 2008-05-23 2012-09-26 NanoCarrier Co., Ltd. Docetaxelpolymerderivat, Verfahren zu seiner Herstellung und Verwendung
CN102421827B (zh) 2009-05-15 2014-07-30 日本化药株式会社 具有羟基的生理活性物质的高分子结合体
KR20140024833A (ko) 2010-11-17 2014-03-03 니폰 가야꾸 가부시끼가이샤 신규한 시티딘계 대사길항제의 고분자 유도체
WO2013009885A2 (en) 2011-07-11 2013-01-17 Momenta Pharmaceuticals, Inc. Evaluation of copolymer diethylamide
US8575198B1 (en) 2011-09-07 2013-11-05 Momenta Pharmaceuticals, Inc. In-process control for the manufacture of glatiramer acetate
RU2623426C2 (ru) 2011-09-11 2017-06-26 Ниппон Каяку Кабусики Кайся Способ получения блок-сополимера
US8691925B2 (en) 2011-09-23 2014-04-08 Az Electronic Materials (Luxembourg) S.A.R.L. Compositions of neutral layer for directed self assembly block copolymers and processes thereof
US8686109B2 (en) * 2012-03-09 2014-04-01 Az Electronic Materials (Luxembourg) S.A.R.L. Methods and materials for removing metals in block copolymers
US10457088B2 (en) 2013-05-13 2019-10-29 Ridgefield Acquisition Template for self assembly and method of making a self assembled pattern
US9093263B2 (en) 2013-09-27 2015-07-28 Az Electronic Materials (Luxembourg) S.A.R.L. Underlayer composition for promoting self assembly and method of making and using
KR20150066151A (ko) 2013-12-06 2015-06-16 삼성전자주식회사 블록 공중합체의 정제 방법 및 블록 공중합체를 이용한 패턴 형성 방법
US9181449B2 (en) 2013-12-16 2015-11-10 Az Electronic Materials (Luxembourg) S.A.R.L. Underlayer composition for promoting self assembly and method of making and using
CN104109235B (zh) * 2014-05-30 2017-07-18 厦门赛诺邦格生物科技股份有限公司 一种具有氮原子支化中心的单一官能化聚乙二醇、制备方法及其生物相关物质
KR101726728B1 (ko) * 2015-07-28 2017-04-14 주식회사 삼양바이오팜 고분자 담체 함유 약학 조성물의 유연물질 분석 방법
US10945997B2 (en) 2016-01-08 2021-03-16 Nippon Kayaku Kabushiki Kaisha Polymer derivative of macrolide immunosuppressant
JP6997764B2 (ja) 2016-08-18 2022-01-18 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング 自己組織化用途用のポリマー組成物
WO2018114930A1 (en) 2016-12-21 2018-06-28 AZ Electronic Materials (Luxembourg) S.à.r.l. Novel compositions and processes for self-assembly of block copolymers
CN107313258A (zh) * 2017-06-23 2017-11-03 安徽金钻智能科技有限公司 一种蚕丝织物精炼用低泡耐碱渗透剂
JP2023138437A (ja) * 2022-03-17 2023-10-02 日油株式会社 ポリエチレングリコール誘導体の製造方法
CN115894905B (zh) * 2022-08-30 2023-08-08 山东华铂凯盛生物科技有限公司 一种高纯度窄分子量分布的甲氧基聚乙二醇-聚（l-谷氨酸钠）的制备方法和应用

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Also Published As

Publication number Publication date
CN1518573A (zh) 2004-08-04
EP1408066B1 (de) 2010-03-31
PL366773A1 (en) 2005-02-07
CN100378140C (zh) 2008-04-02
US7138490B2 (en) 2006-11-21
CA2450448A1 (en) 2003-01-03
RU2282641C2 (ru) 2006-08-27
ATE462746T1 (de) 2010-04-15
ES2343679T3 (es) 2010-08-06
JPWO2003000771A1 (ja) 2004-10-07
KR20040030693A (ko) 2004-04-09
AU2002346296B2 (en) 2007-09-13
US20040151690A1 (en) 2004-08-05
WO2003000771A1 (fr) 2003-01-03
JP4462928B2 (ja) 2010-05-12
PL222061B1 (pl) 2016-06-30
EP1408066A1 (de) 2004-04-14
EP1408066A4 (de) 2004-09-29
CA2450448C (en) 2011-12-13
KR100924990B1 (ko) 2009-11-04
RU2004101281A (ru) 2005-06-27

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