CN100376560C - 新型三环化合物和其作为药物的用途;其制备方法和包含该化合物的药物组合物 - Google Patents
新型三环化合物和其作为药物的用途;其制备方法和包含该化合物的药物组合物 Download PDFInfo
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- CN100376560C CN100376560C CNB98811660XA CN98811660A CN100376560C CN 100376560 C CN100376560 C CN 100376560C CN B98811660X A CNB98811660X A CN B98811660XA CN 98811660 A CN98811660 A CN 98811660A CN 100376560 C CN100376560 C CN 100376560C
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- YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 description 1
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- NRHMKIHPTBHXPF-TUJRSCDTSA-M sodium cholate Chemical compound [Na+].C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC([O-])=O)C)[C@@]2(C)[C@@H](O)C1 NRHMKIHPTBHXPF-TUJRSCDTSA-M 0.000 description 1
- 238000002798 spectrophotometry method Methods 0.000 description 1
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Classifications
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- C07C59/40—Unsaturated compounds
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/734—Ethers
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
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- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- C07D265/38—[b, e]-condensed with two six-membered rings
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- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
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- C07D279/18—[b, e]-condensed with two six-membered rings
- C07D279/22—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom
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- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/18—[b, e]-condensed with two six-membered rings
- C07D279/22—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom
- C07D279/24—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom with hydrocarbon radicals, substituted by amino radicals, attached to the ring nitrogen atom
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- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/18—[b, e]-condensed with two six-membered rings
- C07D279/22—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom
- C07D279/24—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom with hydrocarbon radicals, substituted by amino radicals, attached to the ring nitrogen atom
- C07D279/26—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom with hydrocarbon radicals, substituted by amino radicals, attached to the ring nitrogen atom without other substituents attached to the ring system
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- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- Organic Chemistry (AREA)
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- General Chemical & Material Sciences (AREA)
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
实施例号 | 浓度μM | PPARα | 浓度μM | PPARγ |
实施例11 | 50 | 6.42倍 | 1 | 5.20倍 |
实施例15 | 50 | 3.30倍 | 1 | 6.0倍 |
化合物 | 剂量(mg/kg) | 血葡萄糖含量的减少(%) | 甘油三酯的减少(%) |
实施例14 | 3 | 52 | 61 |
实施例11 | 10 | 66 | 50 |
Claims (16)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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IN2416CH1997 | 1997-10-27 | ||
PCT/US1998/001397 WO1999019313A1 (en) | 1997-10-27 | 1998-01-23 | Novel tricyclic compounds and their use in medicine; process for their preparation and pharmaceutical compositions containing them |
Publications (2)
Publication Number | Publication Date |
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CN1280575A CN1280575A (zh) | 2001-01-17 |
CN100376560C true CN100376560C (zh) | 2008-03-26 |
Family
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CNB98811660XA Expired - Fee Related CN100376560C (zh) | 1997-10-27 | 1998-01-23 | 新型三环化合物和其作为药物的用途;其制备方法和包含该化合物的药物组合物 |
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US (4) | US6054453A (zh) |
EP (1) | EP1049684A1 (zh) |
KR (1) | KR100517644B1 (zh) |
CN (1) | CN100376560C (zh) |
AU (1) | AU749505B2 (zh) |
BR (1) | BR9812772A (zh) |
CA (1) | CA2307820C (zh) |
GB (1) | GB2364304B (zh) |
HU (1) | HUP0100072A3 (zh) |
MX (1) | MXPA00004036A (zh) |
NO (1) | NO316515B1 (zh) |
PL (1) | PL193086B1 (zh) |
RU (1) | RU2235094C2 (zh) |
Families Citing this family (47)
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KR100517644B1 (ko) * | 1997-10-27 | 2005-09-28 | 닥터 레디스 레보러터리즈 리미티드 | 신규의 삼원 화합물 및 그 약학적 용도, 그 제조방법 및이들을 포함하는 약제학적 조성물 |
HUP0101110A3 (en) | 1997-10-27 | 2002-06-28 | Reddys Lab Ltd Dr | Bicyclic compounds, process for their preparation and pharmaceutical compositions containing them |
US6440961B1 (en) | 1997-10-27 | 2002-08-27 | Dr. Reddy's Research Foundation | Tricyclic compounds and their use in medicine: process for their preparation and pharmaceutical compositions containing them |
SE9801992D0 (sv) * | 1998-06-04 | 1998-06-04 | Astra Ab | New 3-aryl-2-hydroxypropionic acid derivative I |
US6365586B1 (en) | 1998-10-21 | 2002-04-02 | Novo Nordisk A/S | Compounds, their preparation and use |
AU763087B2 (en) * | 1998-10-29 | 2003-07-10 | Dr. Reddy's Laboratories Limited | An improved process for the preparation of new antidiabetic agents |
US6531596B1 (en) * | 1998-10-29 | 2003-03-11 | Dr. Reddy's Laboratories Ltd. | Process for the preparation of new antidiabetic agents |
WO2000056328A1 (en) * | 1999-03-19 | 2000-09-28 | Enos Pharmaceuticals, Inc. | Increasing cerebral bioavailability of drugs |
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1998
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- 1998-01-23 CN CNB98811660XA patent/CN100376560C/zh not_active Expired - Fee Related
- 1998-01-23 AU AU60406/98A patent/AU749505B2/en not_active Ceased
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- 1998-01-23 RU RU2000114195/04A patent/RU2235094C2/ru not_active IP Right Cessation
- 1998-01-23 HU HU0100072A patent/HUP0100072A3/hu unknown
- 1998-01-23 BR BR9812772-1A patent/BR9812772A/pt not_active Application Discontinuation
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1999
- 1999-11-23 US US09/448,260 patent/US6939988B1/en not_active Expired - Fee Related
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2000
- 2000-04-26 NO NO20002113A patent/NO316515B1/no unknown
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2001
- 2001-12-06 US US10/007,109 patent/US20020077320A1/en not_active Abandoned
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Also Published As
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HUP0100072A2 (hu) | 2001-08-28 |
PL193086B1 (pl) | 2007-01-31 |
CA2307820C (en) | 2007-04-24 |
GB0010176D0 (en) | 2000-06-14 |
NO316515B1 (no) | 2004-02-02 |
HUP0100072A3 (en) | 2002-11-28 |
US20020077320A1 (en) | 2002-06-20 |
GB2364304B (en) | 2003-04-23 |
AU6040698A (en) | 1999-05-03 |
US20060148793A1 (en) | 2006-07-06 |
EP1049684A1 (en) | 2000-11-08 |
BR9812772A (pt) | 2000-10-10 |
RU2235094C2 (ru) | 2004-08-27 |
GB2364304A (en) | 2002-01-23 |
CN1280575A (zh) | 2001-01-17 |
KR20010031446A (ko) | 2001-04-16 |
CA2307820A1 (en) | 1999-04-22 |
AU749505B2 (en) | 2002-06-27 |
US6054453A (en) | 2000-04-25 |
US6939988B1 (en) | 2005-09-06 |
PL340549A1 (en) | 2001-02-12 |
NO20002113D0 (no) | 2000-04-26 |
US7119198B2 (en) | 2006-10-10 |
KR100517644B1 (ko) | 2005-09-28 |
NO20002113L (no) | 2000-06-26 |
MXPA00004036A (es) | 2006-05-24 |
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