CN100372855C - 具有抗肿瘤活性的喜树碱的7-亚氨基衍生物 - Google Patents

具有抗肿瘤活性的喜树碱的7-亚氨基衍生物 Download PDF

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Publication number
CN100372855C
CN100372855C CNB2004800071482A CN200480007148A CN100372855C CN 100372855 C CN100372855 C CN 100372855C CN B2004800071482 A CNB2004800071482 A CN B2004800071482A CN 200480007148 A CN200480007148 A CN 200480007148A CN 100372855 C CN100372855 C CN 100372855C
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CN
China
Prior art keywords
compound
formula
aminophenyl
phenyl
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB2004800071482A
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English (en)
Chinese (zh)
Other versions
CN1761668A (zh
Inventor
S·达拉瓦莱
S·彭科
C·皮萨诺
F·祖尼诺
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Istituto Nazionale per lo Studio e la Cura die Tumori
Sigma Tau Industrie Farmaceutiche Riunite SpA
Original Assignee
Istituto Nazionale per lo Studio e la Cura die Tumori
Sigma Tau Industrie Farmaceutiche Riunite SpA
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Publication date
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Publication of CN1761668A publication Critical patent/CN1761668A/zh
Application granted granted Critical
Publication of CN100372855C publication Critical patent/CN100372855C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CNB2004800071482A 2003-03-17 2004-03-10 具有抗肿瘤活性的喜树碱的7-亚氨基衍生物 Expired - Fee Related CN100372855C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/388,587 US7105492B2 (en) 1999-03-09 2003-03-17 Camptothecin derivatives having antitumor activity
US10/388,587 2003-03-17

Publications (2)

Publication Number Publication Date
CN1761668A CN1761668A (zh) 2006-04-19
CN100372855C true CN100372855C (zh) 2008-03-05

Family

ID=33029646

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB2004800071482A Expired - Fee Related CN100372855C (zh) 2003-03-17 2004-03-10 具有抗肿瘤活性的喜树碱的7-亚氨基衍生物

Country Status (19)

Country Link
US (2) US7105492B2 (https=)
EP (1) EP1603919B1 (https=)
JP (1) JP4791355B2 (https=)
KR (1) KR101174112B1 (https=)
CN (1) CN100372855C (https=)
AR (1) AR043620A1 (https=)
AT (1) ATE417851T1 (https=)
AU (1) AU2004222044B2 (https=)
BR (1) BRPI0408380A (https=)
CA (1) CA2517450C (https=)
CY (1) CY1108890T1 (https=)
DE (1) DE602004018468D1 (https=)
DK (1) DK1603919T3 (https=)
ES (1) ES2319293T3 (https=)
PL (1) PL1603919T3 (https=)
PT (1) PT1603919E (https=)
SI (1) SI1603919T1 (https=)
TW (1) TWI341840B (https=)
WO (1) WO2004083214A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7105492B2 (en) * 1999-03-09 2006-09-12 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Camptothecin derivatives having antitumor activity
ITRM20030344A1 (it) * 2003-07-14 2005-01-15 Ist Naz Stud Cura Dei Tumori 7-n-poliamminoalchil(ossi)imminometilcamptotecine recanti gruppi protettivi.
ITRM20040288A1 (it) * 2004-06-11 2004-09-11 Sigma Tau Ind Farmaceuti Uso della 7-t-butossiimminometilcamptotecina per la preparazione di un medicamento per il trattamento delle neoplasie dell'utero.
US8975248B2 (en) * 2004-12-15 2015-03-10 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Combinations of therapeutic agents for treating cancer
US7291936B1 (en) * 2006-05-03 2007-11-06 Robson John H Submersible electrical power generating plant
CN102731516B (zh) * 2011-04-07 2014-07-02 宁波天衡药业股份有限公司 一类具有抗肿瘤活性的喜树碱衍生物
WO2022140504A1 (en) * 2020-12-23 2022-06-30 Shanghai Ruotuo Biosciences Co., Ltd. Antibody-drug conjugates, pharmaceutical compositions, and therapeutic applications

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1343209A (zh) * 1999-03-09 2002-04-03 希格马托制药工业公司 具有抗肿瘤活性的喜树碱

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4399276A (en) * 1981-01-09 1983-08-16 Kabushiki Kaisha Yakult Honsha 7-Substituted camptothecin derivatives
JPS58154582A (ja) * 1982-03-10 1983-09-14 Yakult Honsha Co Ltd 新規なカンプトテシン誘導体およびその製造法
DK0612248T3 (da) * 1991-11-15 2003-12-08 Smithkline Beecham Corp Præparat, der indeholder cisplatin og topotecan som antitumormiddel
US5614529A (en) * 1994-09-22 1997-03-25 Research Triangle Institute Inhibition of plasmodia parasites by camptothecin compounds
US5972955A (en) * 1995-06-06 1999-10-26 Dr. Reddy's Research Foundation Water soluble C-ring analogues of 20(S)-camptothecin
IT1282673B1 (it) 1996-02-23 1998-03-31 Ist Naz Stud Cura Dei Tumori Derivati della camptotecina e loro uso come agenti antitumorali
IL127800A (en) 1996-08-19 2005-11-20 Bionumerik Pharmaceuticals Inc Highly lipophilic 7-substituted camptothecin derivatives and pharmaceutical compositions containing them
US7105492B2 (en) * 1999-03-09 2006-09-12 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Camptothecin derivatives having antitumor activity

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1343209A (zh) * 1999-03-09 2002-04-03 希格马托制药工业公司 具有抗肿瘤活性的喜树碱

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS.. DALLAVALLE, S. ET AL.,全文,特别是表格1、2,Novel cytotoxic 7-iminomethyl and 7-aminomethylderivativesof camptothecin.. 2001 *

Also Published As

Publication number Publication date
DE602004018468D1 (de) 2009-01-29
ES2319293T3 (es) 2009-05-06
HK1089160A1 (zh) 2006-11-24
PL1603919T3 (pl) 2009-06-30
AR043620A1 (es) 2005-08-03
EP1603919B1 (en) 2008-12-17
DK1603919T3 (da) 2009-03-09
WO2004083214A1 (en) 2004-09-30
US20040018988A1 (en) 2004-01-29
KR101174112B1 (ko) 2012-08-16
US7105492B2 (en) 2006-09-12
US7351714B2 (en) 2008-04-01
JP2006520807A (ja) 2006-09-14
CA2517450C (en) 2011-06-14
TW200504076A (en) 2005-02-01
CA2517450A1 (en) 2004-09-30
CY1108890T1 (el) 2014-07-02
EP1603919A1 (en) 2005-12-14
US20060167033A1 (en) 2006-07-27
SI1603919T1 (sl) 2009-04-30
PT1603919E (pt) 2009-02-16
JP4791355B2 (ja) 2011-10-12
CN1761668A (zh) 2006-04-19
AU2004222044A1 (en) 2004-09-30
TWI341840B (en) 2011-05-11
KR20050107756A (ko) 2005-11-15
ATE417851T1 (de) 2009-01-15
AU2004222044B2 (en) 2010-02-25
BRPI0408380A (pt) 2006-03-21

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